WO1987007274A2 - Antitumor compositions and their methods of use - Google Patents

Antitumor compositions and their methods of use Download PDF

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Publication number
WO1987007274A2
WO1987007274A2 PCT/US1987/001137 US8701137W WO8707274A2 WO 1987007274 A2 WO1987007274 A2 WO 1987007274A2 US 8701137 W US8701137 W US 8701137W WO 8707274 A2 WO8707274 A2 WO 8707274A2
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
antitumor compositions
marine
antitumor
Prior art date
Application number
PCT/US1987/001137
Other languages
French (fr)
Other versions
WO1987007274A3 (en
Inventor
Amy E. Wright
Winnie C. Thompson
Original Assignee
Harbor Branch Oceanographic Institution, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harbor Branch Oceanographic Institution, Inc. filed Critical Harbor Branch Oceanographic Institution, Inc.
Publication of WO1987007274A2 publication Critical patent/WO1987007274A2/en
Publication of WO1987007274A3 publication Critical patent/WO1987007274A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Compounds with antitumor activity of general formula (I), wherein X1 and X2 are the same or different and are a halogen, compositions and derivatives thereof, a process of producing them and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are derived from marine organisms, i.e., marine sponges Teichaxinella morchella and Ptilocaulis walperis.
PCT/US1987/001137 1986-05-29 1987-05-18 Antitumor compositions and their methods of use WO1987007274A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/868,795 US4729996A (en) 1986-05-29 1986-05-29 Antitumor compositions and their methods of use

Publications (2)

Publication Number Publication Date
WO1987007274A2 true WO1987007274A2 (en) 1987-12-03
WO1987007274A3 WO1987007274A3 (en) 1987-12-17

Family

ID=25352332

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1987/001137 WO1987007274A2 (en) 1986-05-29 1987-05-18 Antitumor compositions and their methods of use

Country Status (4)

Country Link
US (1) US4729996A (en)
EP (1) EP0268652A1 (en)
JP (1) JPH02500738A (en)
WO (1) WO1987007274A2 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0441349A1 (en) * 1990-02-07 1991-08-14 Suntory Limited Pyrroloazepine derivatives
EP0630245A1 (en) * 1992-02-24 1994-12-28 Smithkline Beecham Corporation Protein kinase c inhibitor
US5397780A (en) * 1991-08-07 1995-03-14 Suntory Limited Pyrroloazepine derivative
US5399557A (en) * 1991-08-07 1995-03-21 Suntory Limited Pyrroloazepine compound
EP0693072A1 (en) * 1993-04-08 1996-01-24 The Trustees of Columbia University in the City of New York Method for the synthesis of 4- and/or 5-(di)substituted 2-aminoimidazoles from 2-aminoimidazoles and aldehydes
US5616577A (en) * 1994-08-25 1997-04-01 Smithkline Beecham Corporation Protein Kinase C inhibitor
US6197954B1 (en) 1998-01-30 2001-03-06 The Trustees Of Columbia University In The City Of New York Intermediates for the synthesis of debromohymenialdisine and processes thereof

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4970226A (en) * 1989-10-03 1990-11-13 Harbor Branch Oceanographic Institution, Inc. Bis-indole imidazole compounds which are useful antitumor and antimicrobial agents
US5182287A (en) * 1989-11-03 1993-01-26 Harbor Branch Oceanographic Bioactive heterocycle alkaloids and methods of use
US5073572A (en) * 1990-02-16 1991-12-17 Harbor Branch Oceanographic Institution, Inc. Bioactive metabolites from cribrochalina vasculum
US5028613A (en) * 1990-02-16 1991-07-02 Repligen Corporation Novel pyrroloquinoline alkaloids and methods of use
US5059618A (en) * 1990-07-06 1991-10-22 Harbor Branch Oceanographic Institution, Inc. Novel bioactive discodermides and methods of use
US5091368A (en) * 1990-08-08 1992-02-25 Harbor Branch Oceanographic Institution, Inc. Biologically active compounds from blue-green algae
US5336757A (en) * 1992-02-07 1994-08-09 Harbor Branch Oceanographic Institution, Inc. Antibacterial peptide and methods of use
US5270248A (en) * 1992-08-07 1993-12-14 Mobil Solar Energy Corporation Method for forming diffusion junctions in solar cell substrates
US5298523A (en) * 1992-12-14 1994-03-29 Harbor Branch Oceanographic Institution, Inc. Method for treating transplant patients using mycalamide compounds
US5574057A (en) * 1993-02-03 1996-11-12 University Of Utah Research Foundation Naamidine A extracted from sea sponges and methods for its use as an anti-tumor agent
US5478861A (en) * 1994-02-18 1995-12-26 Harbor Branch Oceanographic Institution, Inc. Cytotoxic macrolides and methods of use
US5684036A (en) * 1994-02-18 1997-11-04 Harbor Branch Oceanographic Institution, Inc. Cytotoxic macrolides and methods of use
JP3714685B2 (en) * 1994-05-18 2005-11-09 第一サントリーファーマ株式会社 Hymenialdisine and its derivatives, methods for producing their synthetic intermediates, and synthetic intermediates thereof
JP2002500190A (en) 1998-01-08 2002-01-08 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Kinesin motor modulators derived from marine sponges
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US7230000B1 (en) 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US6753428B2 (en) * 2001-11-20 2004-06-22 Cytokinetics, Inc. Process for the racemization of chiral quinazolinones
CA2475879A1 (en) * 2002-02-15 2003-08-28 Cytokinetics, Inc. Synthesis of quinazolinones
US7737134B2 (en) * 2002-03-13 2010-06-15 The Texas A & M University System Anticancer agents and use
US7230021B2 (en) * 2002-03-13 2007-06-12 The Texas A&M University System Potent, simplified derivatives of pateamine A
AU2003223786A1 (en) * 2002-05-09 2003-11-11 Cytokinetics, Inc. Compounds, methods and compositions
WO2003097053A1 (en) * 2002-05-09 2003-11-27 Cytokinetics, Inc. Compounds, compositions, and methods
US7038048B2 (en) * 2002-05-23 2006-05-02 Cytokinetics, Inc. 3H-pyridopyrimidin-4-one compounds, compositions, and methods of their use
AU2003236527A1 (en) * 2002-06-14 2003-12-31 Cytokinetics, Inc. Compounds, compositions, and methods
US7135292B2 (en) * 2002-06-28 2006-11-14 Harbor Branch Oceanographic Institution, Inc. Analysis and modification of gene expression in marine invertebrate cells
JP2006501201A (en) * 2002-07-23 2006-01-12 サイトキネティクス・インコーポレーテッド Compounds, compositions and methods
WO2004018058A2 (en) * 2002-08-21 2004-03-04 Cytokinetics, Inc. Compounds, compositions, and methods
US7557115B2 (en) 2002-09-30 2009-07-07 Cytokinetics, Inc. Compounds, compositions, and methods
US6835736B1 (en) 2003-02-28 2004-12-28 Harbor Branch Oceanographic Institution, Inc. Discorhabdin compounds and methods of use
US7053118B1 (en) 2003-03-06 2006-05-30 Harbor Branch Oceanographic Institution, Inc. Lactone compounds and methods of use
WO2005041888A2 (en) * 2003-11-03 2005-05-12 Cytokinetics, Inc. Pyrimidin-4-one compounds, compositions and methods
JP2007510660A (en) * 2003-11-07 2007-04-26 サイトキネティクス・インコーポレーテッド Compounds, compositions and methods
JP2007513154A (en) * 2003-12-08 2007-05-24 サイトキネティクス・インコーポレーテッド Compounds, compositions and methods

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Journal of Organic Chemistry, Volume 50, 1985, American Chemical Society, (Washington, US), K.F. ALBIZATI et al.: "Stevensine, a Novel Alkaloid of an Unidentifeid Marine Sponge", pages 4163-4164 see page 4163, lines 6-20 *
Tetrahedron, Volume 41, No. 24, 1985, Pergamon Press Ltd, (Oxford, GB), G. De NANTEUIL et al.: "Invertebres Marins du Lagon Neo-Caledonien-V", pages 6019-33 see compounds 22 and 23 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206239A (en) * 1990-02-07 1993-04-27 Suntory Limited Pyrroloazepine derivatives
EP0441349A1 (en) * 1990-02-07 1991-08-14 Suntory Limited Pyrroloazepine derivatives
US5399557A (en) * 1991-08-07 1995-03-21 Suntory Limited Pyrroloazepine compound
US5397780A (en) * 1991-08-07 1995-03-14 Suntory Limited Pyrroloazepine derivative
US5565448A (en) * 1992-02-24 1996-10-15 Smithkline Beecham Corporation Medicament
EP0630245A1 (en) * 1992-02-24 1994-12-28 Smithkline Beecham Corporation Protein kinase c inhibitor
EP0630245B1 (en) * 1992-02-24 1999-01-20 Smithkline Beecham Corporation Protein kinase c inhibitor
EP0693072A1 (en) * 1993-04-08 1996-01-24 The Trustees of Columbia University in the City of New York Method for the synthesis of 4- and/or 5-(di)substituted 2-aminoimidazoles from 2-aminoimidazoles and aldehydes
EP0693072A4 (en) * 1993-04-08 1997-09-24 Univ Columbia Method for the synthesis of 4- and/or 5-(di)substituted 2-aminoimidazoles from 2-aminoimidazoles and aldehydes
US6103899A (en) * 1993-04-08 2000-08-15 The Trustees Of Columbia University In The City Of New York Bicyclic aminoimidazoles
US6218549B1 (en) 1993-04-08 2001-04-17 The Trustees Of Columbia University In The City Of New York Bicyclic aminoimidazoles
US5616577A (en) * 1994-08-25 1997-04-01 Smithkline Beecham Corporation Protein Kinase C inhibitor
US6197954B1 (en) 1998-01-30 2001-03-06 The Trustees Of Columbia University In The City Of New York Intermediates for the synthesis of debromohymenialdisine and processes thereof
US6528646B2 (en) 1998-01-30 2003-03-04 The Trustees Of Columbia University In The City Of New York Intermediates for the synthesis of debromohymenialdisine and process thereof

Also Published As

Publication number Publication date
US4729996A (en) 1988-03-08
WO1987007274A3 (en) 1987-12-17
EP0268652A1 (en) 1988-06-01
JPH02500738A (en) 1990-03-15

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