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Medical spray device

Info

Publication number
WO1986002275A1
WO1986002275A1 PCT/SE1985/000385 SE8500385W WO1986002275A1 WO 1986002275 A1 WO1986002275 A1 WO 1986002275A1 SE 8500385 W SE8500385 W SE 8500385W WO 1986002275 A1 WO1986002275 A1 WO 1986002275A1
Authority
WO
Grant status
Application
Patent type
Prior art keywords
container
counter
actuation
aerosol
discharge
Prior art date
Application number
PCT/SE1985/000385
Other languages
French (fr)
Inventor
Karl Holm
Original Assignee
Aktiebolaget Draco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00Containers or packages with special means for dispensing contents
    • B65D83/14Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
    • B65D83/38Details of the container body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • A61M15/0068Indicating or counting the number of dispensed doses or of remaining doses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • A61M15/0068Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007Mechanical counters
    • A61M15/0071Mechanical counters having a display or indicator
    • A61M15/0076Mechanical counters having a display or indicator on a drum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/009Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00Containers or packages with special means for dispensing contents
    • B65D83/14Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
    • B65D83/44Valves specially adapted therefor; Regulating devices
    • B65D83/52Valves specially adapted therefor; Regulating devices for metering
    • B65D83/54Metering valves ; Metering valve assemblies

Abstract

An aerosol device comprising a pressurized aerosol container (4) having a dosing discharge valve (8) adapted to discharge a controlled quantity of fluid from the aerosol container (4) each time it is actuated. A counter (20) is arranged so as to be actuated by each actuation of the discharge valve (8), and said counter (20) being effective to give a visual indication when the container (4) is about to be exhausted.

Description

MEDICAL SPRAY DEVICE

DESCRIPTION

The present invention relates to an aerosol device. Most forms of aerosol device comprise a metal container and a discharge valve through which the fluid within the container may be discharged via a nozzle. The discharge valve may give a continuous spray when they are actuated or they may give a dosed quantity. In either event, it is never clear to the user how much of the fluid remains within the container.

In many instances this will cause no real problems, but it can be very unsatisfactory when the aerosol device is used for dispensing doses of a medicament. One particular type of such aerosol device is in the form of a medical mouth or throat spray device, which includes a holder for an aerosol container designed so as to discharge a predetermined dose of a medicament each time the device is operated, the holder having a spray or atomizing nozzle through which doses are discharged. The aerosol container is provided with a depressable dosing valve having a discharge tube and is mounted or mountable in the holder with this discharge tube received in the recess connected to the atomizer nozzle. The container is inserted and held in an outwardly open guide portion of the holder, such that the container is pressed downwardly in the guide portion, e.g. by applying thumb pressure on the base of the container, so that the discharge nozzle is forced towards the interior of the container thereby discharging the dose of spray.

Devices of this type are used, for example, for dosed supply for the respiratory passages of patients having asthma or other respiratory diseases and they are used and operated by the patients themselves. For the patients, it is often of the utmost importance that they should always have to hand an operative spray device, i.e. they should know when to procure a new device, or at least a new pressurized container, before an existing container has been exhausted. These containers are usually metallic, to with¬ stand the pressure and are thus not transparent, so that the patient cannot directly see how much medicament is left in the container. Theoretically this may be ascer- tained by weighing the container or by a buoyancy test, whereby the container will float at a high level when it is about to be exhausted, but only relatively few patients are capable of carrying out such tests, e.g. determining whether a holiday period or even a weekend can be started without previously obtaining a new container.

According to US-A-3505870, it has already been proposed to provide an aerosol container with a transpa¬ rent window enabling the user to determine the remaining volume of liquid in the container, but this requires a highly undesirable modification of the container itself.

The invention more specifically relates to an aerosol device comprising or consisting of a non-transparent aero¬ sol container of the type operable to produce a predeter¬ mined dose by each actuation, and it is the purpose of the invention to provide an aerosol device of this type, which will enable the user to easily determine when the container is about to be exhausted.

The invention is based on the recognition that this purpose is achievable by automatic counting of the conse- cutive actuations, provided it is known beforehand how many doses the aerosol container can produce. Basically, therefore, the invention resides in the combination of selecting an aerosol container holding a known number of doses and providing for an- automatic counting of the actua- tions of the dosing discharge valve, such that the user may somehow, all according to the manner in which the coun¬ ting is effected, get warned when there is only a small number of doses left in the container.

However, in practice the invention is greatly assis- ted by an already established practice, according to which the aerosol containers of the relevant type are normally marked to hold a guaranteed number of doses, e.g. 200 or 400, and the capacity of a given aerosol container, there¬ fore, will easily be relatable to an automatic counting of the actual doses discharged, without the user having to know the exact number of doses actually present in the single container. The user may simply rely on the guaran¬ teed number and observe the counter having counted up or down to or from this number corresponding to a remaining small number of the number of guaranteed doses. Accordingly, based on this general concept, the in¬ vention is characterized by the features stated in the characterizing clause of claim 1.

It is readily admitted that it is well known in the art to automatically count the doses as discharged through dosing valve means of various containers and bottles, pri¬ marily liquor bottles, but it will be appreciated that this is done for positively counting the discharged doses and not at all for telling the user when the bottle is about to be empty. Such dose counters have been in exist- ence for many years without giving rise to any solution of the problem here in question.

The invention as specifically relating to non-trans¬ parent aerosol containers and to a warning of such a con¬ tainer being "almost exhausted" could well, thus, make use of some known dose counting system, e.g. including a direct operative connection between a discharge valve activating handle means and a counter unit, but the inven¬ tion is still more specifically built on the recognition that such a direct operative connection as established for each single aerosol container is avoidable due to the fact that the normal manner of actuating the discharge valve is to cause a displacement of the entire aerosol container relative the discharge tube thereof as held in said recess in a tube socket in the associated holder. In a highly preferred embodiment of the invention, therefore, the counter unit is arranged so as to be actua- ted by the very displacement of the aerosol container or - even preferably - by the force applied to the container for causing the actuation displacement thereof, whereby the single containers should not be provided with any spe- cial handle means for actuating the associated discharge valves. Thus, according to claim 2, the counter unit may be placed in connection with either the holder unit or the container so as to be operable by the displacement of the container or by the actuation pressing force on the container by each actuation thereof, without the dis¬ charge tube of the container having any kind of direct connection with the counter or with special actuator hand¬ le means.

The counter unit, therefore, may be arranged optional- ly in connection with the holder, so as to count each axial displacement of the container or each actuation pressure thereon as represented by the pressure of the discharge tube against said tube socket.

However, in a preferred embodiment of the invention the counting is effected based on the device normally being actuated by a finger pressure against the exposed bottom portion of the container, whereby the counter unit may comprise an actuation member located on the outside of the bottom portion of the container so as to be operable to effectively transfer an applied actuation pressure to said bottom portion and thereby even operate the counter unit.

Preferably, based on this concept, the actuation member is provided integrally with the counter unit, which, as a cap member, is mounted on the bottom end portion of the aerosol container. The counter unit as hereby being entirely separate from the holder will thus, on receiving an actuation pressure, both count the actuation and get displaced along with the container relative the holder. It will be appreciated that a container as provided with such a counter end cap member may constitute a refill unit to be placed in the holder upon the emptying of the preceding container. The invention, therefore, also com¬ prises such a refill container unit, which can be used without any kind of adaptation for the present purpose. The counter unit of the container unit may be preset in accordance with the guaranteed number of doses of the speci¬ fic container.

The counter unit or member as placed on the bottom end of the container may well be disintegral with the con- tainer or sold as a separate unit, e.g. even for use as an interchangeable end cap member on several consecutively used standard containers, and the invention, therefore, even comprises such a separate counter unit.

The counter unit, generally, may operate according to any suitable principle, e.g. so as to just cause a vis¬ ible signal to be produced when the container is about to be exhausted. Preferably, however, the counter should be an ordinary digital counter steadily displaying its respective counter stages, whereby the counter will enable the patient to follow and control his treatment, inasfar as the counter will make it possible to register the number of doses which the patient inhales during a certain period of time.

In order that the invention may more readily be under- stood, the following description is given, merely by way of example, reference being made to the accompanying draw¬ ings, in which:-

Figure 1 is a side elevation of one embodiment of aerosol device according to the invention; Figure 2 is an enlarged, partly exploded view of the device of Figure 1, with parts being broken away and shown in section;

Figure 3 is an exploded side elevation of device of Figures 1 and 2, with the actuation device being shown in section; Figure 4 is a view similar to the upper part of Figure 3, with the actuation device in position;

Figure 5 is an exploded enlarged perspective view of the counter and actuation member; Figure 6 is a view similar to Figure 4, showing the actuation cap of the actuation member depressed; and

Figure 7 is a perspective view of a second embodiment of aerosol device according to the invention.

Referring first to Figures 1, 2 and 5, the medical spray device illustrated includes a conventional holder 2 and a conventional aerosol container 4 therein. The holder 2 comprises a cylindrical main portion 6, in which the container 4 is received by simply inserting it in an inverted position, whereby a dosing discharge valve having a discharge tube 8 is received in a recess 10. This is formed in an upstanding portion of a bottom wall 12 of the main portion 6. Connected to the recess 10 is a discharge spray nozzle 14, which is surrounded by a laterally extending spout 16. The neck of the container 4 includes the dosing discharge valve, which is actuable for the delivery of a controlled predetermined quantity of fluid from the aerosol container 4, when the container is depressed downwardly to cause the discharge tube 8 to be moved towards the interior of the container. The discharge tube is resiliently biassed, such that all that is necessary is to press the container 4 downwardly in the main portion 6 by finger pressure on the base of the container, whereby the released medicinal dose is discharged via the recess 10 through the nozzle 14 and the spout 16. Only one dose will be produced, irrespective of how long the user holds the container down. When the finger pressure is released, the container will return to its initial position under the action of the' spring bias of the discharge tube 8, without producing any further discharge of medicine. Adjacent the base of the container 4, which is directed upwardly, a counter 20 is provided, this including a holding portion 22 having a lower skirt 24, which engages the circumference of the base portion of the container 4, and an upper actuation cap 26 formed of transparent material. Inside the counter 20 is arranged a counting train which is visible through a lens shaped top 28 of the actuation cap 26. The spray device can be operable by applying finger pressure onto the lens shaped top 28 of the counter, rather than directly on the exposed face of the container. During each actuation, the counter 20 will transfer the required pressure to the container and, at the same time, effect a counting of the actuation, so as to display through the lens shaped top 28 the number of operations or dosages that have been effected since the container 4 and its associated counter were used for the first time. Alternatively, and preferably, the counter unit, when associated with the container or the entire spray device initially, may be designed and adjusted so as to count down the number of actuations from the known number of dosages of the original container. The counter 20 may be designed according to any known counting principle, but need not necessarily be a digital displaying counter, insofar as it achieves the desired result of a physical indication as to the state of the container. This can be marked, e.g., by a red marker coming up into the lens shaped top 28, when there is a predetermined small number of doses remaining in the container.

However, in a preferred construction of the counter, an ordinary mechanical step counter with the required number of digital wheels is provided. This enables the counter to be usable for therapeutic control during the entire lifetime of the container.

The construction of counter shown in Figures 3 to 6 comprises the holding portion 22 and the actuation cap 26, the latter being formed as a short cylinder having its top end providing the lens shaped top 28 and its lower end being provided with an outwardly projecting chamfered flange 30. Inside the actuation cap 26 is arranged a main shaft 32 secured between opposed wall portions of the actuation cap, and a triple wheel digital wheel counter 34. On a second shaft 36 is arranged, but not shown, two transfer wheels forming part of a counter of a well known type. The counter wheels are mounted between two end plates 38,40 which are supported, along their relative edges, against the inside of the actuation cap. The end plate 40 is extended downwardly and is adapted for vertical reciprocation by having a vertical slot 42, through whicht the shaft 32 projects. At its lower left side (Figure 5) the end plate has a pawl 50, which is bent towards the first counter wheel for cooperation with stepping knobs 52 thereon. Thus, the first counter wheel will count a step in response to each upward stroke of the end plate 40.

The holding portion 22 has a cylindrical main body 54, the top end of which has an inwardly projecting chamfered flange 56, while at its lower end, the body 54 has an annular flange 58 just above the skirt 24. In the angle between the flange 58 and the skirt 24 is formed a stepped portion 60.

Between the actuation cap 26 and the holding portion 22 is placed an annular undulating spring 62, which acts between the top side of the annular flange 58 and the annular bottom surface of the actuation cap 26.

The parts 22, 26 and 62 are assembled simply by being pressed together, so that the lower outwardly projecting chamfered flange 30 of the actuation cap 26 will snap under the inwardly projecting chamfered flange 56 of the holding portion 22, thus preventing subsequent separation of these parts. When they are fully pressed together, the spring 62 will become compressed and the end plate 40 is displaced upwardly by contact between its lower flaps 46 and the top side of the annular flange 58. However, the end plate 40 moves against the top portion of the actuation cap 26 so as to be forced down during the last phase of the pressing together of the parts. As a result, due to the shape and position of the flaps 46, which flaps are provided with downwardly converging outer edges 48, these flaps will become forced below the annular flange 58 and will snap out underneath the flange, such that the edge portion of the flange will be received in notches 44, whereafter the end plates 40 will be vertically locked to the flange 58. When the actuation cap is released, the spring 62 will push the actuation cap upwardly until it engages in the flange 56, but the end plate 40 does not participate in this, i.e. it will now be moved so as to prepare the coun¬ ter for actuation by subsequent pressure on the actuation cap . The assembled counter is placed on the base of the container 4, whereby the annular shoulder 60 will provide a free space accommodating the flaps 46 between the end surface of the container base and the underside of the flange 58. Thus, the flaps 46 are not clamped, and it will be possible, therefore, to rotate the actuation cap on the holding portion 22, whereby the user may select any convenient rotational position for the digital counter.

The spring 62 is slightly weaker than, or as strong as, the spring which is provided to bias the discharge nozzle 8 of the container 4.

The operation of the counter will be clear from the foregoing. When the actuation cap 26 is pressed down to the extent that the container delivers a dose (Figure 6), the actuation cap will have been displaced relative to the end plate 40, whereby the counter is actuated and the subsequent release of the button (Figure 5) will cause the counter to become prepared for a subsequent actuation.

Figure 7 shows a modified spray device, in which the container holder, here designated 64, is provided with a counter unit comprising a counter wheel 66. In a manner (not shown) but readily understable to a man skilled in the art, the counter can have an internal actuation member, which is engaged by the neck portion of the container 4, so that depression thereof will cause the counter wheel to rotate one step.

Claims

CL A I MS :
1. An aerosol device comprising or consisting of a non-transparent aerosol container having a dosage dis¬ charge valve adapted to discharge a controlled quantity of fluid from the container each time it is actuated, characterized in that the aerosol container is of the type containing a specified minimum number of doses and that the device comprises a counter arranged so as to be acti¬ vated by each actuation of the discharge valve, the counter being effective to give a visual indication when the container is about to have discharged the specified minimum of doses .
2. An aerosol device according to claim 1 and comprising a holder for the aerosol container, the holder having a re¬ cess for engaging a spring loaded discharge tube of the dosing discharge valve of the container and a spray or atomizing nozzle connected to said recess, whereby, when said container is pushed to be displaced inwardly in said holder the discharge tube is depressed towards the interior of the container to hereby actuate the dosing discharge valve, characterized in that the counter is arranged so as to be activated by each operative displacement of the container or by the pushing force applied to the container for effecting each operative displacement.
3. An aerosol device according to claim 2, character zed in that the counter comprises an actuation member located at the outside of the end portion of the container opposite to said discharge tube, said actuation member being operable to transfer an applied actuation pressure to said container end portion and to hereby also activate the counter.
4. An aerosol device according to claim 3, characterized in that the counter is a counter unit directly associated with said actuation member and placed between said end por¬ tion of the container and sa d actuation member.
5. An aerosol container for use in an aerosol device according to claim 4, provided at one end with a resiliently depressable discharge tube associated with a dosage dis¬ charge valve of or in the container, characterized in that at the opposite end of the container there is arranged a counter unit comprising an outermost actuation member for receiving an actuation pressure towards the container, said counter unit being designed so as to count and dis¬ play its counting for each consecutive application of an actuation pressure against the container.
6. An aerosol container according to claim 5 , charac¬ terized in that the the counter is a conventional multiple digital wheel counter and that the actuation member includes a transparent lens portion to enlarge the display of the counter.
7. An auxiliary unit for use on an end portion of an aerosol container according to claim 5, characterized in that it consists of a counter unit comprising a holding portion adapted to be fastenable to the base end portion of the container and an actuation cap operable to receive an actuation pressure towards said container base end por¬ tion so as to transfer the actuation pressure to the container and additionally count the associated consecutive actuations of the dosage discharge valve of the container.
8. An auxiliary unit according to claim 7, characterized in that the counter is a conventional multiple digital wheel counter, which is housed within a casing as constituted by said holding portion and sa d actuation cap portion, these portions being mutually displaceable to enable an activation of the counter.
PCT/SE1985/000385 1984-10-09 1985-10-08 Medical spray device WO1986002275A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DK481884A DK481884D0 (en) 1984-10-09 1984-10-09 Medical foot or svaelgsprayapparat
DK4818/84 1984-10-09

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI862440A FI862440A (en) 1984-10-09 1986-06-06 Medicinsk sprayanordning.
DK269086A DK269086D0 (en) 1984-10-09 1986-06-09 medicine Spray

Publications (1)

Publication Number Publication Date
WO1986002275A1 true true WO1986002275A1 (en) 1986-04-24

Family

ID=8136917

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1985/000385 WO1986002275A1 (en) 1984-10-09 1985-10-08 Medical spray device

Country Status (7)

Country Link
JP (1) JPS62500361A (en)
DE (1) DE8590143U1 (en)
DK (1) DK481884D0 (en)
EP (1) EP0197113A1 (en)
ES (1) ES8701660A1 (en)
FI (1) FI862440A (en)
WO (1) WO1986002275A1 (en)

Cited By (29)

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EP0254391A1 (en) * 1986-04-25 1988-01-27 Glaxo Group Limited Indicating device for aerosol dispensers
WO1988002865A1 (en) * 1986-10-07 1988-04-21 Microvol Limited Method and apparatus for chemical analysis
US4934358A (en) * 1986-03-24 1990-06-19 Sven-Erik Nilsson Device for self-administration of physiologically active substances, with prevention of overdosing
WO1991006334A1 (en) * 1989-11-03 1991-05-16 Smith Kline & French Laboratories Limited Dosage dispensing devices
US5421482A (en) * 1989-02-03 1995-06-06 Senetics, Inc. Indicator device responsive to axial force
WO1996003172A1 (en) * 1994-07-25 1996-02-08 New-Med Corporation Dispenser monitoring system
US5505195A (en) * 1993-09-16 1996-04-09 Medtrac Technologies Inc. Dry powder inhalant device with dosage and air flow monitor
EP0720568A1 (en) * 1993-09-22 1996-07-10 Senetics, Inc. Indicator device responsive to axial force
US5564414A (en) * 1994-05-26 1996-10-15 Walker; William F. Pressurized and metered medication dose counter on removable sleeve
WO1996039337A1 (en) * 1995-06-06 1996-12-12 Senetics, Inc. Indicator device responsive to axial force
US5622163A (en) * 1994-11-29 1997-04-22 Iep Group, Inc. Counter for fluid dispensers
GB2320489A (en) * 1996-12-20 1998-06-24 Norton Healthcare Ltd Inhaler dose counter
WO1999057019A3 (en) * 1998-05-05 1999-12-29 Jerry R Grychowski Indicating device for aerosol container
WO2000021593A1 (en) 1998-10-08 2000-04-20 Pari GmbH Spezialisten für effektive Inhalation Actuating device for meters and metering aerosol dispensing device with an actuating device for meters
WO2001028887A1 (en) * 1999-10-16 2001-04-26 Glaxo Group Limited Device housing for an aerosol container
WO2001037909A1 (en) * 1999-11-26 2001-05-31 Ernst Hörlins Ingenjörsbyrå Ab Counting mechanism, and spray dose inhaler with said counting mechanism
WO2004009470A2 (en) * 2002-07-19 2004-01-29 Glaxo Group Limited Medicament dispenser
GB2398065A (en) * 2003-10-16 2004-08-11 Bespak Plc Dispensing apparatus
EP1570877A1 (en) * 2004-03-03 2005-09-07 Fujisawa Deutschland GmbH Dose counter for inhalers with trigger means
WO2006004498A1 (en) * 2004-07-05 2006-01-12 Astrazeneca Ab Inhaler device that reduces the risk for miscounting a dosage
WO2007045475A1 (en) * 2005-10-21 2007-04-26 Novartis Ag Dose counting device
WO2008079350A2 (en) * 2006-12-22 2008-07-03 Schering Corporation Dose counter mechanism
US8074594B2 (en) 2003-12-15 2011-12-13 Trudell Medical International Dose indicating device
US8157128B2 (en) 1998-01-16 2012-04-17 Trudell Medical International Indicating device
US8578934B2 (en) 2003-10-28 2013-11-12 Trudell Medical International Indicating device with warning dosage indicator
US8596265B2 (en) 2008-10-22 2013-12-03 Trudell Medical International Modular aerosol delivery system
US8616196B2 (en) 2004-07-02 2013-12-31 Astrazeneca Ab Inhalation device and a method for assembling said inhalation device
US8973784B2 (en) 2005-01-20 2015-03-10 Trudell Medical International Dispensing device
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US5228586A (en) * 1990-08-31 1993-07-20 Ing. Erich Pfeiffer Gmbh & Co. Kg Media dispenser with removable use index
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US6142339A (en) 1998-01-16 2000-11-07 1263152 Ontario Inc. Aerosol dispensing device
DE202004007115U1 (en) * 2004-05-03 2004-07-08 Altana Pharma Ag Blindungsvorrichtung
EP2514466B1 (en) * 2010-05-18 2015-07-01 Ivax Pharmaceuticals Ireland Inhaler with dose counter and method of assembly of an inhaler

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GB1317315A (en) * 1970-12-17 1973-05-16 English Numbering Machines Mechanical impulse counter
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EP0114617B1 (en) * 1983-01-22 1989-03-22 Ing. Erich Pfeiffer GmbH & Co. KG Manually operable dosage device

Cited By (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4934358A (en) * 1986-03-24 1990-06-19 Sven-Erik Nilsson Device for self-administration of physiologically active substances, with prevention of overdosing
EP0254391A1 (en) * 1986-04-25 1988-01-27 Glaxo Group Limited Indicating device for aerosol dispensers
US4817822A (en) * 1986-04-25 1989-04-04 Glaxo Group Limited Indicating device
WO1988002865A1 (en) * 1986-10-07 1988-04-21 Microvol Limited Method and apparatus for chemical analysis
US5421482A (en) * 1989-02-03 1995-06-06 Senetics, Inc. Indicator device responsive to axial force
US5718355A (en) * 1989-02-03 1998-02-17 Senetics, Inc. Indicator device responsive to axial force for use with inhaler
WO1991006334A1 (en) * 1989-11-03 1991-05-16 Smith Kline & French Laboratories Limited Dosage dispensing devices
US5505195A (en) * 1993-09-16 1996-04-09 Medtrac Technologies Inc. Dry powder inhalant device with dosage and air flow monitor
EP0720568A1 (en) * 1993-09-22 1996-07-10 Senetics, Inc. Indicator device responsive to axial force
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Also Published As

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FI862440A (en) 1986-06-06 application
ES547668D0 (en) grant
FI862440A0 (en) 1986-06-06 application
ES8701660A1 (en) 1987-03-01 application
ES547668A0 (en) 1986-12-01 application
DK481884D0 (en) 1984-10-09 grant
JPS62500361A (en) 1987-02-19 application
FI862440D0 (en) grant
EP0197113A1 (en) 1986-10-15 application
DE8590143U1 (en) 1987-04-02 grant

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