WO1986000806A1 - Transdermal delivery of azatadine - Google Patents
Transdermal delivery of azatadine Download PDFInfo
- Publication number
- WO1986000806A1 WO1986000806A1 PCT/US1985/001246 US8501246W WO8600806A1 WO 1986000806 A1 WO1986000806 A1 WO 1986000806A1 US 8501246 W US8501246 W US 8501246W WO 8600806 A1 WO8600806 A1 WO 8600806A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- azatadine
- transdermal
- propylene glycol
- cream
- water
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
Definitions
- This invention relates to the use of azatadine or a salt thereof in pharmaceutical compositions suitable for transdermal delivery, to such transdermal compositions containing azatadine or its salt and to the treatment of allergic' reactions by transdermal application of azatadine or a salt thereof.
- U.S. Pat. No. 4,336,243 discloses a transdermal delivery pad for nitroglycerin administration, nitroglycerin dispersion and transport.
- transdermal drug delivery systems produces more controlled blood levels, lower frequency of dosing and enhanced patient compliance. Further, the transdermal delivery of an antihistamine to treat various allergic reactions is most desirable for reasons of conveninence and effectiveness. Unfortunately, however, until now no antihistamine seemed to possess the properties necessary in order to be effective in a transdermal drug delivery system. These properties are high potency, proper physico-chemical characteristics, good dermal penetration and, lack of dermal irritation and/or sensitization.
- azatadine has been found to possess all of the above described properties which are necessary for being effective in a transdermal drug delivery system.
- a promoter such as dimethyl sulfoxide is used. It is unexpected that azatadine 's transdermal effectiveness is not dependent on the use of such a promoter.
- Azatadine, 6,ll-dihydro-11-( 1-methy1-4- piperidylidene)-5H-benzo[5,6] cyclophepta [1,2-b] pyridine is known as a potent antihi-stamine which is recognized as clinically effective for treating various allergic reactions but until now it has only been applied by the oral route.
- the invention sought to be patented in its method aspect is a pharmaceutical method for treating allergic reactions in a mammal which comprises the transdermal application of an effective amount of azatadine combined with a pharmaceutically acceptable transdermal carrier.
- the invention sought to be patented in a transdermally acceptable pharmaceutical dosage formaulation and or composition comprises an effective amount of azatadine in combination with a pharmaceutically acceptable transdermal carrier.
- the transdermally acceptable composition is utilized to prepare a "resevoir type" or "matrix type” patch which is applied to the skin and worn for a specific period of time to permit the penetration of a desired amount of azatadine through the skin.
- the patch of the invention will be worn for a period of about 24 hours and provide a total daily dosage of about 0.5 mg to about 1.5 mg of azatadine.
- the patch may then be replaced if necessary with a fresh patch, thereby providing a constant blood level of azatadine to the patient in need thereof.
- Azatadine and the preparation thereof are described in U.S. Patent 3,326,924.
- Pharmaceutically acceptable salts of azatadine such as the maleate, sulfate, succinate and acetate salts may also be prepared as described therein and these are equivalent to azatadine for purposes of the invention.
- a preferred pharmaceutically acceptable salt of azatadine is the maleate salt.
- Azatadine is an orally acceptable antihistamine currently approved for sale in the United States and other countries of the world for use in the treatment of allergic disorders such as uritcaria, seasonal rhinitis and pollen sensitivity.
- the skin penetration assembly used was similar to that described by Franz (J. Invest. Derm., 64:190, 1975).
- Excised defatted human skin was stretched across a resevoir containing a phosphate buffer solution (pH 7.4, 0.02M) in direct contact with the dermal side of the skin.
- the temperature of this buffer solution was maintained at 37 ⁇ 0.5'C by circulating water at the appropriate temperature through a jacket which surrounds each assembly.
- Freshly made preparation was applied to the stratum corneum surface.
- the buffer solution was removed in its entirety and replaced with fresh solution at various time intervals and assayed for azatadine content.
- transdermal formulation is not critical to the practice of the invention.
- the invention contemplates the use of any formulation, including those not yet discovered or fully characterized, so long as said transdermal dosage form can be utilized to transdermally deliver the desirable amount of azatadine.
- the total daily dosage (through the skin) of azatadine which is administered by the transdermal formulation may be less than the currently recommended clinical daily administered dose by the oral route.
- the azatadine blood levels will be more consistent and controlled than those obtained upon oral administration of the drug.
- this is not a requirement of the invention.
- the total daily transdermal dosage of azatadine when administered in a patch is expected to be from about 0.2 mg to about 5.0 mg, with 0.5 mg to about 1.5 mg being preferred.
- the particular dosage may be varied depending on the size and age of the patient and may also depend upon the severity of the condition being treated. Such dosage modification is within the skill of the clinical arts.
- the utilization of this new dosage form and its prescribed regimen will provide the recognized clinical efficacy of azatadine, having the advantages described above.
- Other frequencies of dosage application are anticipated, for example, a once every 3 day frequency or a once every 7 day frequency. Although a once a day dosage regimen may be preferred, it is not intended that the invention be limited to any particular regimen.
- Table 2 contains in vitro skin diffusion flux results obtained using human cadaver skin in a Franz diffusion cell, for a 1 cm 2 area, flux is defined as the amount of drug that traverses skin over time for a specified area.
- Ointment A 2.10 7.54 13.83
- Ointment B 3.24 10.16 17.38 Cream 3.01 13.69 27.41 Gel 2.38 7.11 11.79
- Example 1 illustrate formulations of azatadine that show good dermal penetration.
- Polyethylene glycol 1000 18.0 monocetylether
- examples 1-5 can be packaged to produce a "reservoir type" transdermal patch with or without a rate-limiting patch membrane.
- the size of the patch and or the rate limiting membrane can be chosen to deliver the transdermal flux rates desired.
- azatadine and/or its salts can be formulated into a "matrix-type" transdermal patch as in examples 5 and 6.
- Drug Delivery Systems Characteristics and Biomedical Application, R.L. Juliano, ed., Oxford University Press, N.Y. (1980); and Controlled Drug Delivery Vol. I Basic Concepts, Stephen D. Bruck (1983) describe the theory and application of methods useful for transdermal delivery sytems. The relevant teachings of these texts are herein incorporated by reference.
- the drug-matrix could be formed utilizing various polymers, e.g. silicone, polyvinyl alcohol, polyvinyl chloride-vinyl acetate copolymer.
- the "drug matrix” may then be packaged into an appropriate transdermal patch.
- the invention also contemplates a package which contains a specific number of transdermal patches that may be utilized to complete a specified course of treatment. For example, a package containing 7, 24 hours patches would be utilized to complete a one week course of therapy.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Compositions for the transdermal delivery of azatadine and the use of such composition in the treatment of allergic reactions.
Description
TRANSDERMAL DELIVERY OF AZATADINE
This invention relates to the use of azatadine or a salt thereof in pharmaceutical compositions suitable for transdermal delivery, to such transdermal compositions containing azatadine or its salt and to the treatment of allergic' reactions by transdermal application of azatadine or a salt thereof.
In recent years, various drug delivery systems have been developed which provide sustained release therapy via a sub-dermal insert. Systems have been disclosed which also provide drug delivery systems suitable for transdermal drug administration.
U.S. Pat. No. 4,336,243 discloses a transdermal delivery pad for nitroglycerin administration, nitroglycerin dispersion and transport.
The use of transdermal drug delivery systems produces more controlled blood levels, lower frequency of dosing and enhanced patient compliance. Further, the transdermal delivery of an antihistamine to treat various allergic reactions is most desirable for reasons of conveninence and effectiveness.
Unfortunately, however, until now no antihistamine seemed to possess the properties necessary in order to be effective in a transdermal drug delivery system. These properties are high potency, proper physico-chemical characteristics, good dermal penetration and, lack of dermal irritation and/or sensitization.
Quite unexpectedly, azatadine has been found to possess all of the above described properties which are necessary for being effective in a transdermal drug delivery system. Frequently, in order to obtain effective dermal penetration of drugs in a transdermal delivery system, a promoter such as dimethyl sulfoxide is used. It is unexpected that azatadine 's transdermal effectiveness is not dependent on the use of such a promoter.
Azatadine, 6,ll-dihydro-11-( 1-methy1-4- piperidylidene)-5H-benzo[5,6] cyclophepta [1,2-b] pyridine is known as a potent antihi-stamine which is recognized as clinically effective for treating various allergic reactions but until now it has only been applied by the oral route.
The invention sought to be patented in its method aspect is a pharmaceutical method for treating allergic reactions in a mammal which comprises the transdermal application of an effective amount of azatadine combined with a pharmaceutically acceptable transdermal carrier.
The invention sought to be patented in a transdermally acceptable pharmaceutical dosage formaulation and or composition, comprises an effective amount of azatadine in combination with a pharmaceutically acceptable transdermal carrier. Preferably, the transdermally acceptable composition is utilized to prepare a "resevoir type" or "matrix type" patch which is applied to the skin and worn for a specific period of time to permit the penetration of a desired amount of azatadine through the skin. Most preferably, the patch of the invention will be worn for a period of about 24 hours and provide a total daily dosage of about 0.5 mg to about 1.5 mg of azatadine. The patch may then be replaced if necessary with a fresh patch, thereby providing a constant blood level of azatadine to the patient in need thereof.
Azatadine and the preparation thereof are described in U.S. Patent 3,326,924. Pharmaceutically acceptable salts of azatadine such as the maleate, sulfate, succinate and acetate salts may also be prepared as described therein and these are equivalent to azatadine for purposes of the invention. A preferred pharmaceutically acceptable salt of azatadine is the maleate salt.
Azatadine, is an orally acceptable antihistamine currently approved for sale in the United States and other countries of the world for use in the treatment of allergic disorders such as uritcaria, seasonal rhinitis and pollen sensitivity.
In an attempt to find a transdermally effective antihistamine, various known antihistamines were evaluated for their dermal irritation and dermal penetration properties. The results of these evaluations are in Table 1. The irritation results are
reported as either irritating (+) or non-irritating (-), and the penetration results are reported as either good (+) or poor (-). Some antihistamines listed were not tested for in vitro dermal penetration and these are indicated as.
Eight young adult New Zealand white rabbits were assigned to two groups. The rabbits were housed in stainless steel cages and maintained under standard laboratory conditions. Each cage was identified with a color coded label indicating the test substance, rabbit number, sex, and study number. Food and water were supplied ad libitum. On the day of dosing, the back of each rabbit was clipped free of hair. The test substance, a 20% azatadine cream formulation, or a placebo cream was instilled into two Hill Top Chambers and affixed one on each side of the midline of the back. To prevent removal, the chambers were covered with an orthopedic stockinette and secured by a canvas coat. Signs of dermal irritation graded on the basis of criteria presented in Draize, J. H; Dermal Toxicology, An Appraisal Of The 'Safety And Chemical In. Food Drugs & Comesticsj The Association of Food & Drug Officials of the United States 1959 pp 46-59, were recorded after removal of the chambers at 24 and 72 hours.
SCREENING OF ANTIHISTAMINES FOR DERMAL PENETRATION
The skin penetration assembly used was similar to that described by Franz (J. Invest. Derm., 64:190, 1975). Excised defatted human skin was stretched across a resevoir containing a phosphate buffer solution (pH 7.4, 0.02M) in direct contact with the dermal side of the skin. The temperature of this buffer solution was maintained at 37±0.5'C by circulating water at the appropriate temperature through a jacket which surrounds each assembly. Freshly made preparation was applied to the stratum corneum surface. The buffer solution was removed in its entirety and replaced with fresh solution
at various time intervals and assayed for azatadine content.
Several antihistamines were eliminated from consideration as effective transdermal drugs because they were shown to be dermal irritants. Another group of antihistamines, though they showed no dermal irritation, did not show dermal penetration, the latter property being an essential requirement for the effectiveness of a transdermal drug.
The results given in Table 1 reveal that usually antihistamines which give positive results for dermal penetration are unacceptable for transdermal applications because of their dermal irritatant properties. It is surprising to find that after numerous antihistamines were tested, there was only one antihistamine, azatadine, that had good dermal penetration and no dermal irritation and/or sensitization. Thus, the results in Table 1 show that of the compounds tested for transdermal application, only azatadine possess the characteristics necessary for transdermal use.
The use of a particular transdermal formulation is not critical to the practice of the invention. Thus, the invention contemplates the use of any formulation, including those not yet discovered or fully characterized, so long as said transdermal dosage form can be utilized to transdermally deliver the desirable amount of azatadine.
It is of interest to the practice of the present invention that the total daily dosage (through the skin) of azatadine which is administered by the transdermal formulation may be less than the currently recommended clinical daily administered dose by the oral route. Moreover, it is anticipated that upon implementive of the invention the azatadine blood levels will be more consistent and controlled than those
obtained upon oral administration of the drug. However, this is not a requirement of the invention. This feature is anticipated in view of clinical experience with other trandermal drugs. Thus, the total daily transdermal dosage of azatadine when administered in a patch is expected to be from about 0.2 mg to about 5.0 mg, with 0.5 mg to about 1.5 mg being preferred. The particular dosage may be varied depending on the size and age of the patient and may also depend upon the severity of the condition being treated. Such dosage modification is within the skill of the clinical arts. The utilization of this new dosage form and its prescribed regimen will provide the recognized clinical efficacy of azatadine, having the advantages described above. Other frequencies of dosage application are anticipated, for example, a once every 3 day frequency or a once every 7 day frequency. Although a once a day dosage regimen may be preferred, it is not intended that the invention be limited to any particular regimen.
Table 2 contains in vitro skin diffusion flux results obtained using human cadaver skin in a Franz diffusion cell, for a 1 cm2 area, flux is defined as the amount of drug that traverses skin over time for a specified area.
Table 2
Accumulative Azatadine (mg/per cm2)
Formulation3 20 Hr 45 Hr 72 Hr
Ointment A 2.10 7.54 13.83 Ointment B 3.24 10.16 17.38 Cream 3.01 13.69 27.41 Gel 2.38 7.11 11.79
Prepared in Examples 1-4, respectively
This data (Table 2) indicates that azatadine traverses human skin in amounts which are clinically effective. The transdermal dose for clinical effectiveness is expected to be 1 mg/day. Azatadine flux rates of greater than 1 mg day (the preferred daily clinical dosage) were achieved within 20 hours for all of the formulation evaluated (Table 2). Those flux rates achieved a steady-state level between 20-45 hours post patch application. Moreover, these high flux rates were achieved without the use of proraotants (eg dimethyl sulfoxide).
The following examples illustrate formulations of azatadine that show good dermal penetration.
Example 1
Ointment A mg/g
Azatadine 200
White Petrolatum 800
Example 2
Ointment B mg/g
Azatadine 200
Propylene glycol 200
White Petrolatum 600
Example 3
Cream mg/g
Azatadine 200
Mineral Oil 48
White Petrolatum 120
Cetostearyl Alcohol 57.6
Polyethylene glycol 1000 18.0 monocetylether
Propylene glycol 80
Wafer 476.4
Example 4
Gel mg/g
Azatadine 200
Pluronic F-127 250
Ethanol 200
Water 350
Example 5
Patch mg/g
Azatadine 100.00
Mineral Oil 54.0
White Petrolatum 135.0
Ceteryl Alcohol 65.0
Ceteth 20 20.0
Propylene Glycol 100.0
Water q.s. ad 1.0 g
The formulations of examples 1-5 can be packaged to produce a "reservoir type" transdermal patch with or without a rate-limiting patch membrane. The size of the patch and or the rate limiting membrane can be chosen to deliver the transdermal flux rates desired. Alternatively, azatadine and/or its salts can be formulated into a "matrix-type" transdermal patch as in examples 5 and 6. Drug Delivery Systems Characteristics and Biomedical Application, R.L. Juliano, ed., Oxford University Press, N.Y. (1980); and Controlled Drug Delivery Vol. I Basic Concepts, Stephen D. Bruck (1983) describe the theory and application of methods useful for transdermal delivery sytems. The relevant teachings of these texts are herein incorporated by reference. The drug-matrix could be formed utilizing various polymers, e.g. silicone, polyvinyl alcohol, polyvinyl chloride-vinyl acetate copolymer. The "drug matrix" may then be packaged into an appropriate transdermal patch.
Example 6
Patch mg/g
Azatadine 200 silicone polymer 800
Example 7
Patch mg/g
Azatadine 300
Polyvinyl chloride vinyl acetate co-polymer 700
The invention also contemplates a package which contains a specific number of transdermal patches that may be utilized to complete a specified course of treatment. For example, a package containing 7, 24 hours patches would be utilized to complete a one week course of therapy.
Claims
1. Transdermally effective topical anti-allergic pharmaceutical compositions comprising, as an active ingredient, azatadine or a salt thereof in combination with pharmaceutically acceptable transdermal carriers.
2. Composition according to claim 1 which is formulated as an ointment.
3. An ointment according to claim 2 which comprises 200 mg of azatadine and 800 mg of white petrolatum.
4. An ointment according to claim 2 which comprises 200 mg of azatadine, 200 mg of propylene glycol and 600 mg of white, petrolatum.
5. Composition according to claim 1 which is formulated as a cream.
6. A cream according to claim 5 which comprises 25-250 mg azatadine, 25-100 mg mineral oil, 50-200 mg white petrolatum, 30-100 mg cetearyl alcohol, 10-50 ceteth 20, 50-200 mg propylene glycol and water, the quantities of the ingredients being selected so that it gives a total of 1 g.
7. A cream according to claim 6 which comprises 100 mg azatadine, 54 mg mineral oil, 135 mg white petrolatum, 65 mg cetearyl alcohol, 20 mg ceteth 20, 100 mg propylene glycol and water to make a total weight of 1 g.
8. A cream according to claim 5 which comprises 200 mg of azatadine, 48 mg of mineral oil, 120 mg of white petrolatum, 57.6 mg of cetostearyl alcohol, 18 mg of polyethylene glycol 1000 monocetyl ether, 80 mg of propylene glycol and 476.4 mg of water.
9. Composition according to claim 1 which is formulated as a gel.
10. Gel defined according to claim 8 which comprises 200 mg of azatadine, 250 mg of pluronic F- 127, 200 mg of ethanol and 350 mg of water.
11. Composition according to claim 1 in the form of a patch.
12. The use of azatadine in combination with pharmaceutically acceptable transdermal carriers in topical transdermal treatment of allergic disorders.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE8585903582T DE3573532D1 (en) | 1984-07-23 | 1985-07-01 | TRANSDERMAL DELIVERY OF AZATADINE |
AT85903582T ATE47036T1 (en) | 1984-07-23 | 1985-07-01 | TRANSDERMAL ADMINISTRATION OF AZATIDIN. |
DK131586A DK164844C (en) | 1984-07-23 | 1986-03-21 | TRANSDERMALLY EFFECTIVE TOPIC ANTIALLERGIC PHARMACEUTICAL COMPOSITION CONTAINING AZATADIN AND USING AZATADIN FOR THE PREPARATION OF SUCH A MEDICINE FOR TOPIC TRANSDERMAL TREATMENT OF ALLERGIC DISEASES |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63354184A | 1984-07-23 | 1984-07-23 | |
US633,541 | 1990-12-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1986000806A1 true WO1986000806A1 (en) | 1986-02-13 |
Family
ID=24540048
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1985/001246 WO1986000806A1 (en) | 1984-07-23 | 1985-07-01 | Transdermal delivery of azatadine |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0188538B1 (en) |
JP (1) | JPS61502751A (en) |
AU (1) | AU576884B2 (en) |
CA (1) | CA1263602A (en) |
DE (1) | DE3573532D1 (en) |
DK (1) | DK164844C (en) |
IL (2) | IL75853A0 (en) |
NZ (1) | NZ212800A (en) |
WO (1) | WO1986000806A1 (en) |
ZA (1) | ZA855485B (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0267051A2 (en) * | 1986-11-07 | 1988-05-11 | Purepac, Inc. | Transdermal administration of amines |
US4877618A (en) * | 1988-03-18 | 1989-10-31 | Reed Jr Fred D | Transdermal drug delivery device |
US5422118A (en) * | 1986-11-07 | 1995-06-06 | Pure Pac, Inc. | Transdermal administration of amines with minimal irritation and high transdermal flux rate |
CN110087640A (en) * | 2016-12-20 | 2019-08-02 | 罗曼治疗系统股份公司 | Transdermal therapeutic system comprising asenapine |
US11033512B2 (en) | 2017-06-26 | 2021-06-15 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine and silicone acrylic hybrid polymer |
US11337932B2 (en) | 2016-12-20 | 2022-05-24 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene |
US11648213B2 (en) | 2018-06-20 | 2023-05-16 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3435114A (en) * | 1965-11-08 | 1969-03-25 | Mead Johnson & Co | Topical antihistaminic compositions containing methdilazine sulfoxide |
DE1795745A1 (en) * | 1963-04-24 | 1974-08-29 | Scherico Ltd | MEDICINAL PRODUCTS CONTAINING 5-SUBSTITUTED 4-AZA-DIBENZOCYCLOHEPTENS |
-
1985
- 1985-07-01 AU AU46082/85A patent/AU576884B2/en not_active Ceased
- 1985-07-01 EP EP85903582A patent/EP0188538B1/en not_active Expired
- 1985-07-01 WO PCT/US1985/001246 patent/WO1986000806A1/en active IP Right Grant
- 1985-07-01 DE DE8585903582T patent/DE3573532D1/en not_active Expired
- 1985-07-01 JP JP60503136A patent/JPS61502751A/en active Pending
- 1985-07-19 CA CA000487162A patent/CA1263602A/en not_active Expired
- 1985-07-19 NZ NZ212800A patent/NZ212800A/en unknown
- 1985-07-19 IL IL75853A patent/IL75853A0/en not_active IP Right Cessation
- 1985-07-19 IL IL74853A patent/IL74853A/en unknown
- 1985-07-19 ZA ZA855485A patent/ZA855485B/en unknown
-
1986
- 1986-03-21 DK DK131586A patent/DK164844C/en not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1795745A1 (en) * | 1963-04-24 | 1974-08-29 | Scherico Ltd | MEDICINAL PRODUCTS CONTAINING 5-SUBSTITUTED 4-AZA-DIBENZOCYCLOHEPTENS |
US3435114A (en) * | 1965-11-08 | 1969-03-25 | Mead Johnson & Co | Topical antihistaminic compositions containing methdilazine sulfoxide |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0267051A2 (en) * | 1986-11-07 | 1988-05-11 | Purepac, Inc. | Transdermal administration of amines |
EP0267051A3 (en) * | 1986-11-07 | 1990-10-03 | Moleculon Inc. | Transdermal administration of amines |
US5422118A (en) * | 1986-11-07 | 1995-06-06 | Pure Pac, Inc. | Transdermal administration of amines with minimal irritation and high transdermal flux rate |
US4877618A (en) * | 1988-03-18 | 1989-10-31 | Reed Jr Fred D | Transdermal drug delivery device |
CN110087640A (en) * | 2016-12-20 | 2019-08-02 | 罗曼治疗系统股份公司 | Transdermal therapeutic system comprising asenapine |
US20190336454A1 (en) * | 2016-12-20 | 2019-11-07 | Lts Lohmann Therapie-Systeme Ag | Transdermal Therapeutic System Containing Asenapine |
US10898449B2 (en) | 2016-12-20 | 2021-01-26 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
US10980753B2 (en) | 2016-12-20 | 2021-04-20 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
US11337932B2 (en) | 2016-12-20 | 2022-05-24 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene |
US11033512B2 (en) | 2017-06-26 | 2021-06-15 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine and silicone acrylic hybrid polymer |
US11648213B2 (en) | 2018-06-20 | 2023-05-16 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
Also Published As
Publication number | Publication date |
---|---|
AU4608285A (en) | 1986-02-25 |
DK164844C (en) | 1993-01-11 |
JPS61502751A (en) | 1986-11-27 |
IL74853A (en) | 1988-08-31 |
ZA855485B (en) | 1986-03-26 |
DK131586D0 (en) | 1986-03-21 |
DK164844B (en) | 1992-08-31 |
IL75853A0 (en) | 1985-11-29 |
EP0188538B1 (en) | 1989-10-11 |
CA1263602A (en) | 1989-12-05 |
NZ212800A (en) | 1989-01-06 |
EP0188538A1 (en) | 1986-07-30 |
DK131586A (en) | 1986-03-21 |
AU576884B2 (en) | 1988-09-08 |
DE3573532D1 (en) | 1989-11-16 |
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