WO1986000090A1 - Hybrid protein and fused gene encoding gene - Google Patents
Hybrid protein and fused gene encoding gene Download PDFInfo
- Publication number
- WO1986000090A1 WO1986000090A1 PCT/US1985/001081 US8501081W WO8600090A1 WO 1986000090 A1 WO1986000090 A1 WO 1986000090A1 US 8501081 W US8501081 W US 8501081W WO 8600090 A1 WO8600090 A1 WO 8600090A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hybrid protein
- sequence
- fragment
- gene
- fused gene
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/25—Shigella (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE8585903136T DE3586456T2 (en) | 1984-06-07 | 1985-06-07 | HYBRID PROTEIN. |
AT85903136T ATE79136T1 (en) | 1984-06-07 | 1985-06-07 | HYBRID PROTEIN. |
FI860541A FI100253B (en) | 1984-06-07 | 1986-02-06 | Hybrid protein and process for the preparation and use thereof |
NO860421A NO176807C (en) | 1984-06-07 | 1986-02-06 | A fused gene encoding a hybrid protein, as well as a method for producing a hybrid protein encoded by a fused gene; vector and fused gene |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61819984A | 1984-06-07 | 1984-06-07 | |
US618,199 | 1984-06-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1986000090A1 true WO1986000090A1 (en) | 1986-01-03 |
Family
ID=24476731
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1985/001081 WO1986000090A1 (en) | 1984-06-07 | 1985-06-07 | Hybrid protein and fused gene encoding gene |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0185076B1 (en) |
JP (2) | JP2510984B2 (en) |
AT (1) | ATE79136T1 (en) |
AU (1) | AU592310B2 (en) |
CA (1) | CA1339359C (en) |
DE (1) | DE3586456T2 (en) |
ES (2) | ES8708014A1 (en) |
FI (1) | FI100253B (en) |
NO (1) | NO176807C (en) |
NZ (1) | NZ212312A (en) |
WO (1) | WO1986000090A1 (en) |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0261671A2 (en) * | 1986-09-24 | 1988-03-30 | Ira Pastan | Recombinant pseudomonas exotoxin: construction of an active immunotoxin with low side effects |
WO1988009344A1 (en) * | 1987-05-21 | 1988-12-01 | Creative Biomolecules, Inc. | Targeted multifunctional proteins |
EP0385659A2 (en) * | 1989-03-03 | 1990-09-05 | Fujita Health University | Multifunctional polypeptides and method for the preparation thereof |
EP0439954A2 (en) * | 1989-12-22 | 1991-08-07 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
US5091513A (en) * | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
US5132405A (en) * | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
US5258498A (en) * | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
US5621083A (en) * | 1991-11-04 | 1997-04-15 | Xoma Corporation | Immunotoxins comprising ribosome-inactivating proteins |
US5668255A (en) * | 1984-06-07 | 1997-09-16 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
US5837491A (en) * | 1991-11-04 | 1998-11-17 | Xoma Corporation | Polynucleotides encoding gelonin sequences |
US5863891A (en) * | 1990-03-02 | 1999-01-26 | Boston Medical Center Corporation | Chimeric toxins |
US6022953A (en) * | 1989-04-19 | 2000-02-08 | Chiron Corporation | Multifunctional M-CSF proteins and genes encoding therefor |
US6146850A (en) * | 1991-11-04 | 2000-11-14 | Xoma Corporation | Proteins encoding gelonin sequences |
US6635740B1 (en) | 1997-03-27 | 2003-10-21 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Ligand/lytic peptide compositions and methods of use |
US6680058B1 (en) | 1997-09-03 | 2004-01-20 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Compositions and methods for contraception in or sterilization of mammals |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU570762B2 (en) * | 1983-12-23 | 1988-03-24 | Australian National University, The | Cloning of cdna for il-3 |
AU577856B2 (en) * | 1985-01-17 | 1988-10-06 | Immunex Corporation | Cloning and characterization of the human interleukin 1 gene |
JPH082315B1 (en) * | 1987-05-29 | 1996-01-17 | Sagami Chuo Kagaku Kenkyusho | |
JPH09500102A (en) * | 1993-04-28 | 1997-01-07 | ウォーセスター ファウンデーション フォー エクスペリメンタル バイオロジー | Cell-directed dissolution pore forming agent |
US5777078A (en) * | 1993-04-28 | 1998-07-07 | Worcester Foundation For Experimental Biology | Triggered pore-forming agents |
AU8586298A (en) | 1997-07-25 | 1999-02-16 | University Of Massachusetts | Designed protein pores as components for biosensors |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4468382A (en) * | 1982-07-15 | 1984-08-28 | New England Medical Center, Inc. | Polypeptide-toxin hybrid protein |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2534222B2 (en) * | 1982-05-12 | 1996-09-11 | プレジデント アンド フエロウズ オブ ハ−バ−ド カレツジ | Fusion gene for mixed protein production |
-
1985
- 1985-06-05 NZ NZ212312A patent/NZ212312A/en unknown
- 1985-06-05 ES ES543938A patent/ES8708014A1/en not_active Expired
- 1985-06-07 DE DE8585903136T patent/DE3586456T2/en not_active Expired - Fee Related
- 1985-06-07 EP EP85903136A patent/EP0185076B1/en not_active Expired - Lifetime
- 1985-06-07 AT AT85903136T patent/ATE79136T1/en not_active IP Right Cessation
- 1985-06-07 CA CA000483407A patent/CA1339359C/en not_active Expired - Fee Related
- 1985-06-07 WO PCT/US1985/001081 patent/WO1986000090A1/en active IP Right Grant
- 1985-06-07 JP JP60502723A patent/JP2510984B2/en not_active Expired - Lifetime
- 1985-06-07 AU AU44916/85A patent/AU592310B2/en not_active Ceased
-
1986
- 1986-02-06 NO NO860421A patent/NO176807C/en not_active IP Right Cessation
- 1986-02-06 FI FI860541A patent/FI100253B/en active IP Right Grant
- 1986-10-01 ES ES557103A patent/ES8801376A1/en not_active Expired
-
1993
- 1993-12-01 JP JP5302099A patent/JPH06205684A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4468382A (en) * | 1982-07-15 | 1984-08-28 | New England Medical Center, Inc. | Polypeptide-toxin hybrid protein |
Non-Patent Citations (18)
Title |
---|
Applied and Environmental Microbiology, Volume 46, pages 560-564, issued September 1983, RINO RAPPUOLI, Isolation and Characterization of Corynebacterium Diphtheriae Nontandem Double Lysogens Hyperproducing CRM 197. * |
Endocrinology, Volume 113, pages 1072-1076, issued 1983, P. BACHA et al, Organ-Specific Binding of a Thyrotropin-Releasing Hormone-Diphtheria Toxin Complex after Intravenous Administration to Rats. * |
Infection and Immunity, Volume 42, pages 48-56, issued October 1983, NEAL GROMAN et al, Detection and Expression of DNA-Homologous to the Tox Gene in Nontoxinogenic Isolates of Corynebacterium Diphtheriae. * |
Journal of Bacteriology, Volume 148, pages 124-130, issued October 1981, JOHN J. COSTA et al, Restriction Map of Coryne Bacteriophages beta-sub-C and beta-sub-Vir and Physical Localization of the Diphtheria Tox Operon. * |
Journal of Bacteriology, Volume 148, pages 153-162, issued October 1981 GREGORY A. BUCK et al, Identification of DNA Restriction Fragments of Beta-Converting Corynebacteriophages that Carry the Gene of Diphtheria Toxin. * |
Journal of Bactriology, Volume 156, pages 680-685, issued November 1983, R. K. TWETEN et al, Mollcular Cloning and Expression of Gene Fragments from Corynebacteriophage Beta Encoding Enzymatically Active Peptides of Diphtheria Toxin. * |
Journal of Biological Chemistry, Volume 258, pages 1565-1570, issued 1983, PATRICIA BACHA et al, Thyrotropin-Releasing Hormone-Diphtheria Toxin-Related Polypeptide Conjugates. * |
Journal of Cellular Biochemistry, Supplement, Volume 0, Number 6, page 133, Abstract 0364, issued 1982, N. SHIMUZU et al, Toxin-Hormone Conjugates and Resistant Variants. * |
Journal of Cellular Biochemistry, Volume 20, pages 163-176, issued 1982, HARVEY R. HERSCHMAN et al, Toxic Logand Conjugates as Tools in the Study of Receptor-Ligand Interactions. * |
Proceedings of the Miami Winter Symposia, Volume 19, pages 275-288, issued 1982, DIANE M. ROBINS et al, Expression of the Human Growth Hormone Gene is Regulated in Mouse Cells. * |
Proceedings of the National Academy of Sciences, USA, Volume 79, pages 2475-2479, issued April 1982, MASONORI SUZUKI et al, Production in Escherichia Coli of Biologically Active Secretin, A Gastrointestinal Hormone. * |
Proceedings of the National Academy of Sciences, USA, Volume 80, pages 5863-6857, issued November 1983, LAWRENCE GREENFIELD et al, Nucleotide Sequence of the Structural L Gene for Diphtheria Toxin carried by Coryne Bacteriophage beta. * |
Science, Volume 220, pages 515-517, issued 29 April 1983, DIANE LEONG et al, Cloned Fragment A of Diphtheria Toxin is Expressed and Escherichia Coli K12. * |
Science, Volume 221, pages 855-858, issued 26 August 1983, MICHEL KACZOREK et al, Nucleotide Sequence and Expression of the Diphtheria Tox 228 Gene in Escherichia Coli. * |
See also references of EP0185076A4 * |
Seminars in Infectious Disease, Volume 4, pages 81-82, issued 1982, JOHN R. MURPHY, Diphtheria Toxin, Cross-Reacting Nontoxic Proteins, and the Development of New Biologicals. see page 85. * |
The Harvey Lectures, Volume 76, pages 45-74, issued 1982, ALWIN M. PAPPENHEIMER, Diphtheria: Studies on the Biology of an Infectious Disease. * |
The Journal of Biological Chemistry, Volume 258, pages 15016-15020, issued 25 December 1983, DIANE LEONG et al, Cloned Diphtheria Toxin Fragment A is Expressed from the Tox Promoter and Exported to the Periplasm by Sec-A Apparatus of Escherichia Coli K12. see page 10520. * |
Cited By (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5668255A (en) * | 1984-06-07 | 1997-09-16 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
EP0261671A2 (en) * | 1986-09-24 | 1988-03-30 | Ira Pastan | Recombinant pseudomonas exotoxin: construction of an active immunotoxin with low side effects |
EP0261671A3 (en) * | 1986-09-24 | 1988-08-10 | Ira Pastan | Recombinant pseudomonas exotoxin: construction of an active immunotoxin with low side effects |
EP0583794A1 (en) * | 1986-09-24 | 1994-02-23 | Ira Pastan | Recombinant pseudomonas exotoxin: construction of an active immunotoxin with low side effects |
US5258498A (en) * | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
US5091513A (en) * | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
US5132405A (en) * | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
WO1988009344A1 (en) * | 1987-05-21 | 1988-12-01 | Creative Biomolecules, Inc. | Targeted multifunctional proteins |
US5476786A (en) * | 1987-05-21 | 1995-12-19 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
US5482858A (en) * | 1987-05-21 | 1996-01-09 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
EP0385659A3 (en) * | 1989-03-03 | 1991-02-27 | Fujita Health University | Multifunctional polypeptides and method for the preparation thereof |
EP0834562A1 (en) * | 1989-03-03 | 1998-04-08 | Fujita Health University | Polypetide exhibiting calpain inhibition activity and method for the preparation thereof |
EP0385659A2 (en) * | 1989-03-03 | 1990-09-05 | Fujita Health University | Multifunctional polypeptides and method for the preparation thereof |
US6022953A (en) * | 1989-04-19 | 2000-02-08 | Chiron Corporation | Multifunctional M-CSF proteins and genes encoding therefor |
EP0439954A3 (en) * | 1989-12-22 | 1992-05-20 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
EP0439954A2 (en) * | 1989-12-22 | 1991-08-07 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
US5863891A (en) * | 1990-03-02 | 1999-01-26 | Boston Medical Center Corporation | Chimeric toxins |
US5932471A (en) * | 1990-03-02 | 1999-08-03 | Boston Medical Center Corporation | DNA encoding chimeric toxin |
US5756699A (en) * | 1991-11-04 | 1998-05-26 | Xoma Corporation | Immunotoxins comprising ribosome-inactivating proteins |
US5837491A (en) * | 1991-11-04 | 1998-11-17 | Xoma Corporation | Polynucleotides encoding gelonin sequences |
US5621083A (en) * | 1991-11-04 | 1997-04-15 | Xoma Corporation | Immunotoxins comprising ribosome-inactivating proteins |
US5744580A (en) * | 1991-11-04 | 1998-04-28 | Xoma Corporation | Immunotoxins comprising ribosome-inactivating proteins |
US6146850A (en) * | 1991-11-04 | 2000-11-14 | Xoma Corporation | Proteins encoding gelonin sequences |
US6146631A (en) * | 1991-11-04 | 2000-11-14 | Xoma Corporation | Immunotoxins comprising ribosome-inactivating proteins |
US6376217B1 (en) | 1991-11-04 | 2002-04-23 | Xoma Technology Ltd. | Fusion proteins and polynucleotides encoding gelonin sequences |
US6649742B1 (en) | 1991-11-04 | 2003-11-18 | Xoma Technology Ltd. | Immunotoxins comprising ribosome-inactivating proteins |
US6635740B1 (en) | 1997-03-27 | 2003-10-21 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Ligand/lytic peptide compositions and methods of use |
US7566777B2 (en) | 1997-03-27 | 2009-07-28 | Board Of Supervisors Of Louisana State University And Agricultural And Mechanical College | Genes encoding hormone and lytic peptides |
US6680058B1 (en) | 1997-09-03 | 2004-01-20 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Compositions and methods for contraception in or sterilization of mammals |
Also Published As
Publication number | Publication date |
---|---|
CA1339359C (en) | 1997-08-26 |
NO176807B (en) | 1995-02-20 |
DE3586456D1 (en) | 1992-09-10 |
FI100253B (en) | 1997-10-31 |
JPS61502304A (en) | 1986-10-16 |
DE3586456T2 (en) | 1993-03-25 |
JPH06205684A (en) | 1994-07-26 |
NZ212312A (en) | 1988-09-29 |
AU4491685A (en) | 1986-01-10 |
JP2510984B2 (en) | 1996-06-26 |
EP0185076B1 (en) | 1992-08-05 |
NO176807C (en) | 1995-05-31 |
AU592310B2 (en) | 1990-01-11 |
ES8801376A1 (en) | 1987-12-16 |
ATE79136T1 (en) | 1992-08-15 |
NO860421L (en) | 1986-02-06 |
FI860541A0 (en) | 1986-02-06 |
FI860541A (en) | 1986-02-06 |
ES557103A0 (en) | 1987-12-16 |
EP0185076A1 (en) | 1986-06-25 |
ES543938A0 (en) | 1987-09-01 |
EP0185076A4 (en) | 1987-11-09 |
ES8708014A1 (en) | 1987-09-01 |
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