WO1984001904A1 - A device for rinsing and treating wounds and infected skin portions - Google Patents

A device for rinsing and treating wounds and infected skin portions

Info

Publication number
WO1984001904A1
WO1984001904A1 PCT/SE1983/000439 SE8300439W WO1984001904A1 WO 1984001904 A1 WO1984001904 A1 WO 1984001904A1 SE 8300439 W SE8300439 W SE 8300439W WO 1984001904 A1 WO1984001904 A1 WO 1984001904A1
Authority
WO
Grant status
Application
Patent type
Prior art keywords
cup
treatment
solution
pressure
member
Prior art date
Application number
PCT/SE1983/000439
Other languages
French (fr)
Inventor
Gunnar Swanbeck
Original Assignee
Gunnar Swanbeck
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/008Drainage tubes; Aspiration tips
    • A61M1/0088Drainage tubes; Aspiration tips with a seal, e.g. to stick around a wound for isolating the treatment area
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/0058Suction-irrigation systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00Drainage appliances for wounds or the like, i.e. wound drains, implanted drains
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00Medical syringes, e.g. enemata; Irrigators
    • A61M3/02Enemata; Irrigators
    • A61M3/0229Devices operating in a closed circuit, i.e. recycling the irrigating fluid

Abstract

A device for rinsing and treating wounds and infected skin portions and comprising a suction cup (10) which is placed over the area to be treated and a vessel (15) for a treatment solution, said vessel by way of a tube connection (11, 12) communicating with the interior of the suction cup. The treatment solution is intended to fill up at least a substantial part of the volume of the suction cup (10). The vessel (15) and suction cup form by way of the tube connection a closed liquid system for the treatment solution. A pump (13) may be arranged to cause the solution to circulate between the suction cup (10) and the vessel (15). A suction effect is created within the cup (10) by keeping this on a level above the vessel (15).

Description

A device for rins ing and treating wounds and infected skin portions

Technical field

The present invention refers to a device for rinsing and treating wounds and infected skin portions and comprising a cup-shaped member covering the area to be treated and having its opening towards this, said device further comprising a vessel for a treatment solution, said vessel by way of a tube connection communicates with the interior of the cup-shaped member, at which the treatment solution is intended to fill up at least a substantial part of the volume of the cup-shaped member and forming a liquid surface against the area to be treated for exchanging components between this and the treatment solution, and wherein the interior of the cup-shaped member is arranged to be kept at a lower pressure than the atmospheric pressure.

Background of the invention

The conventional method for treating chronical and infected wounds, such as bedsores, leg ulcers etc. is manual washing and moist compresses soaked with a common salt solution and if necessary enzymes for promoting the healing process. In recent

R years a new medical preparation called Debrisan consisting of small, dry, porous beads has been used to a limited extent and is declared to have a better absorption capacity as compared to most common salt compresses.

Divices for risning and treating wounds have also been proposed, in which a cup with its opening facing the wound is applied about the wound area, said cup having an inlet and an outlet opening and a liquid is caused to pass through the cup. Said liquid can contain antibiotics and substances which improves the healing process. Bacteria and waste products from the wound are washed away with the cleansing slution. Such a device is shown in DE-OS 2.809.828 and US patent No. 2.280.915. Since often long treatment periods are required for obtaining a desired result large volumes of cleansing solution are consumed, which means great expenses especially if the solution contains substances as antibiotics, enzyme preparations, vitamines etc.

The purpo se and most important fea tures of the invention

The object of the present invention is to provide a device of the kind mentioned in the introduction, which makes it possible to treat wounds and infected skin portions in an economically justified way even during long periods of time and which improves the healing of the wound and besides in certain cases can compensate for an insufficient bloodcirculation, e.g. in leg ulcers.

This has been achieved by the fact that said vessel and cup-shaped member by way of said tube connection form a closed liquid system thereby providing a uniform low pressure within the cup-shaped member, which may be regulated by the level difference between the cup-shaped member and the vessel.

Description of the drawings

The invention will now be further described with reference to the accompanying drawings, where Fig. 1 and 2 schematically show two different embodiments of the invention.

Description fo the embodiments

The device according to Fig 1 comprises a suction cup 10 of rubber, plastic or glass and which has an inlet and an outlet opening, to which a feed and a discharge tube 11 and 12 resp. are connected. The discharge tube 12 leads by way of a pump 13 and a sterilizing filter 14 down into a bottle 15 containing a treatment solution. The pump 13 is preferably a so called peristaltic pump. The tube 11 connected to the inlet opening of the suction cup 10 leads from the bottle 15. The interior of the bottle 15 is kept at atmospheric pressure by means of an air tube 15. Oxygen may also be bubbled into the solution by way of a tube 17 to ensure oxygenation of the wound to be treated. The suction cup is applied over the wound area or the infected skin portions to be treated. The solution is caused to circulate through the system and is prevented from leaking out from the suction cup 10 by applying a pressure to the cup. This pressure may be created by an external bandage or by having a somewhat lower pressure inside the cup than in the surrounding atmosphere. This lower pressure may be regulated by the level difference between the bottle and the suction cup. i.e. the hydrostatic pressure difference. It can also be regulated by the flow resistance between the bottle and the suction cup and by the speed of flow. The pressure can also be regulated by a separate pressure regulator.

The low pressure in the suction cup provides besides preventing leaking from the suction cup, that interstitial fluid is sucked out from the wound and facilitates that blood components are transported to the wound and that microorganisms are easier washed away from the wound.

The suction cup may be of different sizes, shapes and materials, such as glass, rubber or plastic etc. The suction cup has an opening towards the skin area to be treated and inlet and outlet openings for the solution. The size of the opening towards the skin may vary from some mm2 to some dm2

The volume of the solution may vary from some ml to several liters.

The sterlizing filter 14 which may either be placed between the pump 13 and the bottle 15 or between the suction cup 10 and the pump can have a porosity of about 0.22 micron, to filter out all bacteria, up to about 0.80 micron to get a good degree of cleaning of the solution. The sterilizing filter 14 is however in most cases unnecessary and can thus be eliminated.

The bottle 15 with the treatment solution may be placed in a thermostatically regulated water bath to ensure a certain temperature of the treatment solution.

The active ingredients in the solution to be circulated may be a cleaning agent, compounds for nutrition of the tissue including oxygen, vitamins, amino acids and glucose, drugs of different types such as antibiotics, antiinflammatory agents, e.g. cortison, and enzymes for digestion of necrotic tissue, coagulum and pus.

The solution may be of the types used for intravenous infusion or for skin cleaning. It is however possible that a better result may be obtained with new developed solutions for this special pupose.

The circulation of the solution enables a larger volume of the solution and by that a greater amount of nutritives, drugs etc. to come in contact with the wound to be treated and to get a continuous sterilization of the solution if the sterilizing filter 14 is used. The circulation will also give an effective cleaning of the wound as the solution all the time will be flowing over the wound and wash away waste products therefrom. As was mentioned above a continuous oxygenation of the wound may easily be obtained by bubbling oxygen into the treatment solution in the bottle.

Especially at chronic leg ulcers the device according to this invention may be regarded as a substitute for the insufficient blood circulation in the ulcer area.

If a continuous treatment is desired during a long period of time the filter 14 and the treatment solution may be exchanged e.g. by arranging a T-connection with a valve between the bottle 15 and the suction cup 10 and between the pump 13 and the filter 14. In the embodiment shown in Fig. 2 the pump is eliminated and th cup 10 is connected to the bottle 15 only by way of the tube 11. The outlet opening 10 of the cup is closable. The solution is caused to raise into the cup 10 through the tube 11 by raising the bottle 15 to a higher level, at which the outlet opening of the cup is open. When the solution starts flowing out through said opening this is closed by a stopper 18 or the like, after which the bottle is lowered to a level below the cup 10. The interior of the cup will then have a negative pressure corresponding to the level difference to the bottle. A certain natural circulation caused by convection will take place within the cup, at which there will be an exchange of components between the wound and the treatment solution.

In practice it may be appropriate to start a treatment with the device according to Fig. 1 and when the healing process has advanced change to the device according to Fig. 2

The most important fields of application for the device according to the invention are:

1. Cleaning of chronic and infected ulcers such as pressure ulcers, leg ulcers etc.

2. Substituting and complementing the blood circulation in arterial- or venous insufficiency of the legs in leg ulcer patients.

3. Administration of drugs such as antibiotics and antiinflammatory compounds in a controlled and exact way in for instance vasculitis ulcers.

4. Treatment of superficial skin infections, such as impetigo, herpes simplex and mycoses. Clinical tests have been performed with the device according to Fig. 1 and the results thereof will be given below. Clinical tests

The patients have been treated for approximately two hours daily till the lesions have healed. If pain was felt due to the low pressure the treatment was stopped when the patient so wanted. In one of the patients the treatment was stopped after 45 minutes the first week of treatment. Subsequently the patient could stand treatment for two hours daily. Two patients with leg ulcers due to an established arterial insufficiency, two patients with ulcers due to venous insufficiency, one patient with a diabetic ulcer and one patient with pyoderma gangrenosum have taken part in the preliminary clinical trial. One of the patients with arterial insufficiency had two ulcers that were treated, not simultaneously but in succession.

Case 1. 93-year old woman that after childbirth got problems with varicous veins and subcequently had several deep vein thromboses. Since the age of 80 she suffered from recurrent leg ulcers. Some months before treatment started with external circulation she got several ulcerations on both legs. Oscillometry and systolic ankle and toe pressure gave values indicating threatening gangraene. Treatment with external circulation gave complete epithelialization in nine weeks.

Case 2. 73-year old man who earlier had vein thromboses three times in his left leg. The first leg ulcer came in 1968 and has recurred since then in both legs but mostly in his left leg. In 1980 he was considered having a combined arterial and venous insufficiency causing his leg ulcerations. He was operated for insufficient perforating veins in his left leg the same year. After the operating the surgical wound did not heal. The patient also developed some other ulcerations on the same leg. First we started treating the initial three year old surgical wound with external circulation. After nine weeks when this ulcer was healed, we went on with treating another wound distal and lateral to the surgical wound. After seven weeks of treatment the wound was epithelialized over 80 percent of its surface.

Case 3. 65-year old woman with diabetes and hypertension. She had a small traumatic υlceration on the ventral side of the left leg in 1948. The ulceration has recurred several times but since 1978 it had not healed in spite of several types of treatment including reconstructive surgery . In 1982 toe pressure in the first left toe was 30 mmHG indicating arterial insufficiency. After eight weeks of treatment with external circulation the ulcer was healed.

Case 4. 57-year old woman with mild hypertension who had vein thrombosis in her left leg in 1957 and 1973. The patient had a 1.5x2 centimeter ulcer for half a year over the left medial melleolus when treatment with external circulation was started. After three weeks of treatment the ulceration was healed.

Case 5. 63-year old man with recurrent leg ulcerations since 1976. He had no sign of arterial insufficiency. In August 1982 he got a 1 centimeter ulceration on the medial side of his left leg. In February 1983 he got another 1 centimeter ulcer close to the former. Both ulcers were treated simulaneously with external circulation and both were healed in three weeks.

Case 6. 27-year old woman with pyoderma gengrenosum since 1972. The ulceration have mainly appeared on her legs and arms. For the last 18 months she had had ulcerations all the time and refused taking prednisolon. One of her fresh ulcers had a diameter slightly over 1.5 centimeter. After three weeks of treatment the ulcer was heald.

Results

Daily treatment with external circulation of a nutrient solution under low pressure has been effective in healing the seven ulcerations of the six patients. For the three patients without arterial insufficiency the healing rate has been considerably shorter than for those with arterial insufficiency on the basis of arteriosclerosis or diabetes mellitus.

When the daily treatment was stopped there was an oedema under the treatment cup. The oedema disappeared within a few hours. Pain was recorded for one patient after the low pressure had been applied for about 45 minutes. After a few weeks of treatment the pain did not appear.

For two patients albumin determination in the circulating nutrient fluid after two hours of treatment was performed. Values corresponding to about 0.5 ml of serum was obtained.

For the patients with arterial insufficiency including the diabetic patient the ulcers healed first with an epithelialization and later on after the treatment had been stopped the dermal defect was filled out. Epitheialization thus seemed to proceed granulation under the conditions of this type of treatment.

The invention is of course not limited to the embodiments shown in the drawings but can be notified within the scope of the claims.

Claims

Claims
1. A device for rinsing and treating wounds and infected skin portions and comprising a cup-shaped member (10) covering the area to be treated and having its opening towards this, said device further comprising a vessel (15) for a treatment solution, said vessel by way of a tube connection communicates with the interior of the cup-shaped member, at which the treatment solution is intended to fill up at least a substantial part of the volume of the cup-shaped member and forming a liquid surface against the area to be treated for exchanging components between this and the treatment solution, and wherein the interior of the cup-shaped member (10) is arranged to be kept at a lower pressure than the atmospheric pressure, c h a r a c t e r i z e d i n, that said vessel (15) and cup-shaped member (10) by way of said tube connection (11,12) form a closed liquid system, thereby providing a uniform low pressure within the cup-shaped member, which may be regulated by the level difference between the cup-shaped member and the vessel (15).
2. A device according to claim 1, c h a r a c t e r i z e d i n, that a tube connection (11) is arranged between the vessel (15) and an inlet opening in the cup-shaped member (10) and a second tube connection (12) is arranged between an outlet opening in the cup-shaped member and the vessel, and that a pump (13) is provided at said second tube connection for causing the treatment solution to circulate between the cup-shaped member and the vessel.
3. A device according to claim 2, c h a r a c t e r i z e d i n, that a sterlizing filter (14) is arranged between said outlet opening and the vessel (15).
4. A device according to claim 1, c h a r a c t e r i z e d i n, that the vessel (15) by way of a tube connection (11) is connected to an opening in the cup-shaped member (10), which has a second closable opening and that in use of the device the tube and at least a substantial part of the cup-shaped member are filled with treatment solution and said second opening is closed, at which the low pressure in the cup-shaped member is maintained and can be regulated by the level difference between the cup-shaped member and the vessel.
PCT/SE1983/000439 1982-11-17 1983-11-15 A device for rinsing and treating wounds and infected skin portions WO1984001904A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SE8206533 1982-11-17

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP50382083A JPS59502014A (en) 1982-11-17 1983-11-15
DK348984A DK348984D0 (en) 1982-11-17 1984-07-17 An apparatus for cleaning and treating wounds

Publications (1)

Publication Number Publication Date
WO1984001904A1 true true WO1984001904A1 (en) 1984-05-24

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1983/000439 WO1984001904A1 (en) 1982-11-17 1983-11-15 A device for rinsing and treating wounds and infected skin portions

Country Status (3)

Country Link
EP (1) EP0142501A1 (en)
JP (1) JPS59502014A (en)
WO (1) WO1984001904A1 (en)

Cited By (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0325771A2 (en) * 1988-01-25 1989-08-02 Gunter Siegel Treatment device for parts of the human body
WO2004037334A1 (en) * 2002-10-28 2004-05-06 Smith & Nephew Plc Apparatus for aspirating, irrigating and cleansing wounds
WO2005046762A1 (en) * 2003-10-28 2005-05-26 Smith & Nephew Plc Wound cleansing apparatus with scaffold
WO2005046760A1 (en) * 2003-10-28 2005-05-26 Smith & Nephew Plc Wound cleansing apparatus with heat
WO2005046761A1 (en) * 2003-10-28 2005-05-26 Smith & Nephew Plc Wound cleansing apparatus with actives
WO2005105176A1 (en) * 2004-04-27 2005-11-10 Smith & Nephew, Plc Wound cleansing apparatus with flowstress
WO2005105174A1 (en) * 2004-04-27 2005-11-10 Smith & Nephew, Plc Wound cleansing apparatus with stress
WO2005105175A1 (en) * 2004-04-27 2005-11-10 Smith & Nephew, Plc Wound cleansing apparatus with ultrasound
WO2006114638A2 (en) * 2005-04-27 2006-11-02 Smith & Nephew, Plc Wound treating apparatus and method
US7753894B2 (en) * 2004-04-27 2010-07-13 Smith & Nephew Plc Wound cleansing apparatus with stress
EP1807145A4 (en) * 2004-11-05 2011-04-20 Squibb Bristol Myers Co Vacuum wound dressing
US7964766B2 (en) * 2003-10-28 2011-06-21 Smith & Nephew Plc Wound cleansing apparatus in-situ
US8235972B2 (en) 2006-02-01 2012-08-07 Carmeli Adahan Suctioning system, method and kit
US8506554B2 (en) 2005-07-24 2013-08-13 Carmeli Adahan Wound closure and drainage system
US8715256B2 (en) 2007-11-21 2014-05-06 Smith & Nephew Plc Vacuum assisted wound dressing
US8764732B2 (en) 2007-11-21 2014-07-01 Smith & Nephew Plc Wound dressing
US8808274B2 (en) 2007-11-21 2014-08-19 Smith & Nephew Plc Wound dressing
US8845619B2 (en) 2004-04-27 2014-09-30 Smith & Nephew Plc Wound treatment apparatus and method
US8945074B2 (en) 2011-05-24 2015-02-03 Kalypto Medical, Inc. Device with controller and pump modules for providing negative pressure for wound therapy
US9017302B2 (en) 2008-07-21 2015-04-28 Smith & Nephew, Inc. Thin film wound dressing
US9044569B2 (en) 2004-04-28 2015-06-02 Smith & Nephew Plc Wound dressing apparatus and method of use
US9050399B2 (en) 2007-07-02 2015-06-09 Smith & Nephew Plc Wound treatment apparatus with exudate volume reduction by heat
US9058634B2 (en) 2011-05-24 2015-06-16 Kalypto Medical, Inc. Method for providing a negative pressure wound therapy pump device
US9061095B2 (en) 2010-04-27 2015-06-23 Smith & Nephew Plc Wound dressing and method of use
US9067003B2 (en) 2011-05-26 2015-06-30 Kalypto Medical, Inc. Method for providing negative pressure to a negative pressure wound therapy bandage
US9155821B2 (en) 2009-06-10 2015-10-13 Smith & Nephew, Inc. Fluid collection canister including canister top with filter membrane and negative pressure wound therapy systems including same
US9192700B2 (en) 2008-01-08 2015-11-24 Bluesky Medical Group, Inc. Sustained variable negative pressure wound treatment and method of controlling same
US9199012B2 (en) 2008-03-13 2015-12-01 Smith & Nephew, Inc. Shear resistant wound dressing for use in vacuum wound therapy
US9198801B2 (en) 2004-04-05 2015-12-01 Bluesky Medical Group, Inc. Flexible reduced pressure treatment appliance
US9205235B2 (en) 2008-09-05 2015-12-08 Smith & Nephew, Inc. Canister for wound therapy and related methods therefor
US9211365B2 (en) 2002-09-03 2015-12-15 Bluesky Medical Group, Inc. Reduced pressure treatment system
US9272080B2 (en) 2004-05-21 2016-03-01 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
US9302034B2 (en) 2011-04-04 2016-04-05 Smith & Nephew, Inc. Negative pressure wound therapy dressing
US9415145B2 (en) 2008-08-21 2016-08-16 Smith & Nephew, Inc. Sensor with electrical contact protection for use in fluid collection canister and negative pressure wound therapy systems including same
US9414968B2 (en) 2008-09-05 2016-08-16 Smith & Nephew, Inc. Three-dimensional porous film contact layer with improved wound healing
US9474654B2 (en) 2008-08-08 2016-10-25 Smith & Nephew, Inc. Wound dressing of continuous fibers
US9492326B2 (en) 2004-04-05 2016-11-15 Bluesky Medical Group Incorporated Reduced pressure wound treatment system
US9579431B2 (en) 2009-04-17 2017-02-28 Kalypto Medical, Inc. Negative pressure wound therapy device
US9889241B2 (en) 2009-06-01 2018-02-13 Smith & Nephew, Inc. System for providing continual drainage in negative pressure wound therapy
US9931446B2 (en) 2008-07-17 2018-04-03 Smith & Nephew, Inc. Subatmospheric pressure mechanism for wound therapy system and related methods therefor
US9956325B2 (en) 2009-05-11 2018-05-01 Smith & Nephew, Inc. Orientation independent canister for a negative pressure wound therapy device
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Cited By (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0325771A2 (en) * 1988-01-25 1989-08-02 Gunter Siegel Treatment device for parts of the human body
EP0325771A3 (en) * 1988-01-25 1990-12-19 Gunter Siegel Treatment device for parts of the human body
US9211365B2 (en) 2002-09-03 2015-12-15 Bluesky Medical Group, Inc. Reduced pressure treatment system
WO2004037334A1 (en) * 2002-10-28 2004-05-06 Smith & Nephew Plc Apparatus for aspirating, irrigating and cleansing wounds
US9844474B2 (en) 2002-10-28 2017-12-19 Smith & Nephew Plc Apparatus for aspirating, irrigating and cleansing wounds
US8834451B2 (en) 2002-10-28 2014-09-16 Smith & Nephew Plc In-situ wound cleansing apparatus
US9205001B2 (en) 2002-10-28 2015-12-08 Smith & Nephew Plc Apparatus for aspirating, irrigating and cleansing wounds
US9844473B2 (en) 2002-10-28 2017-12-19 Smith & Nephew Plc Apparatus for aspirating, irrigating and cleansing wounds
US7524315B2 (en) 2002-10-28 2009-04-28 Smith & Nephew Plc Apparatus for aspirating, irrigating and cleansing wounds
US9289542B2 (en) 2003-10-28 2016-03-22 Smith & Nephew Plc Wound cleansing apparatus
US9446178B2 (en) 2003-10-28 2016-09-20 Smith & Nephew Plc Wound cleansing apparatus in-situ
JP2007509681A (en) * 2003-10-28 2007-04-19 スミス アンド ネフュー ピーエルシーSmith & Nephew Public Limited Company Wound cleaning devices using heat
US8882746B2 (en) 2003-10-28 2014-11-11 Smith & Nephew Plc Wound cleansing apparatus with scaffold
US7699830B2 (en) 2003-10-28 2010-04-20 Smith & Nephew Plc Wound cleansing apparatus with scaffold
US9452248B2 (en) 2003-10-28 2016-09-27 Smith & Nephew Plc Wound cleansing apparatus in-situ
US7794450B2 (en) 2003-10-28 2010-09-14 Smith & Nephew Plc Wound cleansing apparatus with heat
US20110009835A1 (en) * 2003-10-28 2011-01-13 Smith & Nephew Plc Wound cleansing apparatus with heat
WO2005046761A1 (en) * 2003-10-28 2005-05-26 Smith & Nephew Plc Wound cleansing apparatus with actives
WO2005046760A1 (en) * 2003-10-28 2005-05-26 Smith & Nephew Plc Wound cleansing apparatus with heat
US9616208B2 (en) 2003-10-28 2017-04-11 Smith & Nephew Plc Wound cleansing apparatus
WO2005046762A1 (en) * 2003-10-28 2005-05-26 Smith & Nephew Plc Wound cleansing apparatus with scaffold
US8926592B2 (en) * 2003-10-28 2015-01-06 Smith & Nephew Plc Wound cleansing apparatus with heat
US7964766B2 (en) * 2003-10-28 2011-06-21 Smith & Nephew Plc Wound cleansing apparatus in-situ
US9492326B2 (en) 2004-04-05 2016-11-15 Bluesky Medical Group Incorporated Reduced pressure wound treatment system
US9198801B2 (en) 2004-04-05 2015-12-01 Bluesky Medical Group, Inc. Flexible reduced pressure treatment appliance
US9526817B2 (en) 2004-04-27 2016-12-27 Smith & Nephew Plc Wound cleansing apparatus with stress
US8845619B2 (en) 2004-04-27 2014-09-30 Smith & Nephew Plc Wound treatment apparatus and method
US7753894B2 (en) * 2004-04-27 2010-07-13 Smith & Nephew Plc Wound cleansing apparatus with stress
WO2005105175A1 (en) * 2004-04-27 2005-11-10 Smith & Nephew, Plc Wound cleansing apparatus with ultrasound
WO2005105174A1 (en) * 2004-04-27 2005-11-10 Smith & Nephew, Plc Wound cleansing apparatus with stress
WO2005105176A1 (en) * 2004-04-27 2005-11-10 Smith & Nephew, Plc Wound cleansing apparatus with flowstress
US9452244B2 (en) 2004-04-27 2016-09-27 Smith & Nephew Plc Wound cleansing apparatus with stress
US9545463B2 (en) 2004-04-28 2017-01-17 Smith & Nephew Plc Wound treatment apparatus and method
US9044569B2 (en) 2004-04-28 2015-06-02 Smith & Nephew Plc Wound dressing apparatus and method of use
US9950100B2 (en) 2004-04-28 2018-04-24 Smith & Nephew Plc Negative pressure wound therapy dressing system
US9272080B2 (en) 2004-05-21 2016-03-01 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
US9925313B2 (en) 2004-05-21 2018-03-27 Smith & Nephew, Inc. Flexible reduced pressure treatment appliance
US9381283B2 (en) 2004-11-05 2016-07-05 Convatec Technologies Inc. Vacuum wound dressing
EP1807145A4 (en) * 2004-11-05 2011-04-20 Squibb Bristol Myers Co Vacuum wound dressing
EP1807145B1 (en) 2004-11-05 2016-03-23 ConvaTec Technologies Inc. Vacuum wound dressing
WO2006114638A2 (en) * 2005-04-27 2006-11-02 Smith & Nephew, Plc Wound treating apparatus and method
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