WO1982004393A1 - Method and composition for treating acne - Google Patents
Method and composition for treating acne Download PDFInfo
- Publication number
- WO1982004393A1 WO1982004393A1 PCT/US1981/001063 US8101063W WO8204393A1 WO 1982004393 A1 WO1982004393 A1 WO 1982004393A1 US 8101063 W US8101063 W US 8101063W WO 8204393 A1 WO8204393 A1 WO 8204393A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- weight
- composition
- powder
- clay
- sulfurated lime
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 77
- 238000000034 method Methods 0.000 title claims abstract description 36
- 206010000496 acne Diseases 0.000 title claims description 23
- 208000002874 Acne Vulgaris Diseases 0.000 title claims description 21
- JNVCSEDACVAATK-UHFFFAOYSA-L [Ca+2].[S-]SSS[S-] Chemical compound [Ca+2].[S-]SSS[S-] JNVCSEDACVAATK-UHFFFAOYSA-L 0.000 claims abstract description 41
- 229940051851 sulfurated lime Drugs 0.000 claims abstract description 41
- 229960000892 attapulgite Drugs 0.000 claims description 28
- 229910052625 palygorskite Inorganic materials 0.000 claims description 28
- 239000000843 powder Substances 0.000 claims description 28
- 239000002594 sorbent Substances 0.000 claims description 23
- 239000000440 bentonite Substances 0.000 claims description 16
- 229910000278 bentonite Inorganic materials 0.000 claims description 16
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 16
- 239000004927 clay Substances 0.000 claims description 16
- 239000005995 Aluminium silicate Substances 0.000 claims description 15
- 235000012211 aluminium silicate Nutrition 0.000 claims description 15
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 15
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 14
- 235000012216 bentonite Nutrition 0.000 claims description 12
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 claims description 12
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 12
- 206010039792 Seborrhoea Diseases 0.000 claims description 11
- 230000037312 oily skin Effects 0.000 claims description 11
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 claims description 10
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 8
- 229910000271 hectorite Inorganic materials 0.000 claims description 8
- KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 claims description 8
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims description 7
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 7
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 7
- 229930002330 retinoic acid Natural products 0.000 claims description 7
- 239000000454 talc Substances 0.000 claims description 7
- 229910052623 talc Inorganic materials 0.000 claims description 7
- 229960001727 tretinoin Drugs 0.000 claims description 7
- 239000004606 Fillers/Extenders Substances 0.000 claims description 6
- 229960004889 salicylic acid Drugs 0.000 claims description 6
- 230000001877 deodorizing effect Effects 0.000 claims description 5
- 229910052901 montmorillonite Inorganic materials 0.000 claims description 5
- 239000003921 oil Substances 0.000 claims description 5
- 239000000049 pigment Substances 0.000 claims description 5
- 239000011593 sulfur Substances 0.000 claims description 5
- 229910052717 sulfur Inorganic materials 0.000 claims description 5
- 239000002537 cosmetic Substances 0.000 claims description 4
- 238000011200 topical administration Methods 0.000 claims description 4
- 229910052782 aluminium Inorganic materials 0.000 claims description 3
- 229940009868 aluminum magnesium silicate Drugs 0.000 claims description 3
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 claims description 3
- 230000003255 anti-acne Effects 0.000 claims description 3
- 239000008180 pharmaceutical surfactant Substances 0.000 claims description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 235000010216 calcium carbonate Nutrition 0.000 claims 5
- 229910021647 smectite Inorganic materials 0.000 claims 5
- 235000012222 talc Nutrition 0.000 claims 5
- 229960001755 resorcinol Drugs 0.000 claims 4
- 229910000275 saponite Inorganic materials 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 235000019645 odor Nutrition 0.000 description 18
- 238000011282 treatment Methods 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 239000000262 estrogen Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 229940011871 estrogen Drugs 0.000 description 7
- 239000008213 purified water Substances 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- KKEBXNMGHUCPEZ-UHFFFAOYSA-N 4-phenyl-1-(2-sulfanylethyl)imidazolidin-2-one Chemical compound N1C(=O)N(CCS)CC1C1=CC=CC=C1 KKEBXNMGHUCPEZ-UHFFFAOYSA-N 0.000 description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 239000000378 calcium silicate Substances 0.000 description 4
- 229910052918 calcium silicate Inorganic materials 0.000 description 4
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 210000002374 sebum Anatomy 0.000 description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 239000000443 aerosol Substances 0.000 description 3
- 230000001076 estrogenic effect Effects 0.000 description 3
- 239000004744 fabric Substances 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000010186 staining Methods 0.000 description 3
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 2
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- -1 aluminum silicates Chemical class 0.000 description 2
- 239000012050 conventional carrier Substances 0.000 description 2
- 230000002939 deleterious effect Effects 0.000 description 2
- 229960002568 ethinylestradiol Drugs 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229930195215 pungen Natural products 0.000 description 2
- 210000001732 sebaceous gland Anatomy 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 239000008279 sol Substances 0.000 description 2
- 238000005494 tarnishing Methods 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- SKDFWEPBABSFMG-UHFFFAOYSA-N 1,2-dichloro-1,1-difluoroethane Chemical compound FC(F)(Cl)CCl SKDFWEPBABSFMG-UHFFFAOYSA-N 0.000 description 1
- HXDLWJWIAHWIKI-UHFFFAOYSA-N 2-hydroxyethyl acetate Chemical compound CC(=O)OCCO HXDLWJWIAHWIKI-UHFFFAOYSA-N 0.000 description 1
- CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical compound BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 description 1
- 206010006313 Breast tenderness Diseases 0.000 description 1
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- AGVJBLHVMNHENQ-UHFFFAOYSA-N Calcium sulfide Chemical class [S-2].[Ca+2] AGVJBLHVMNHENQ-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- NILRAGIKYDJKNI-UHFFFAOYSA-N FCF.[Cl].[Cl] Chemical compound FCF.[Cl].[Cl] NILRAGIKYDJKNI-UHFFFAOYSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010058015 Infected cyst Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 206010046788 Uterine haemorrhage Diseases 0.000 description 1
- 206010064008 Vulvovaginal adenosis Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 229940030486 androgens Drugs 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
- 229940095259 butylated hydroxytoluene Drugs 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000003575 carbonaceous material Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 239000002734 clay mineral Substances 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- SASYSVUEVMOWPL-NXVVXOECSA-N decyl oleate Chemical compound CCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC SASYSVUEVMOWPL-NXVVXOECSA-N 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229960003276 erythromycin Drugs 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 230000001135 feminizing effect Effects 0.000 description 1
- 239000003517 fume Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 201000000079 gynecomastia Diseases 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- IMSSROKUHAOUJS-MJCUULBUSA-N mestranol Chemical compound C1C[C@]2(C)[C@@](C#C)(O)CC[C@H]2[C@@H]2CCC3=CC(OC)=CC=C3[C@H]21 IMSSROKUHAOUJS-MJCUULBUSA-N 0.000 description 1
- 229960001390 mestranol Drugs 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229940127234 oral contraceptive Drugs 0.000 description 1
- 239000003539 oral contraceptive agent Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 206010046885 vaginal cancer Diseases 0.000 description 1
- 208000013139 vaginal neoplasm Diseases 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/08—Oxides; Hydroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/12—Magnesium silicate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB08303242A GB2110932B (en) | 1981-06-12 | 1981-08-10 | Method and composition for treating acne |
DE813152893T DE3152893A1 (en) | 1981-06-12 | 1981-08-10 | METHOD AND COMPOSITION FOR TREATING ACNE |
AT0910981A ATA910981A (en) | 1981-06-12 | 1981-08-10 | METHOD FOR PRODUCING COSMETIC AND THERAPEUTIC COMPOSITIONS |
NL8120306A NL8120306A (en) | 1981-06-12 | 1981-08-10 | |
BR8109030A BR8109030A (en) | 1981-06-12 | 1981-08-10 | PROCESS AND COMPOSITION FOR ACNE TREATMENT |
JP50278981A JPS58500897A (en) | 1981-06-12 | 1981-08-10 | Treatment method and composition for acne |
SE8300718A SE8300718L (en) | 1981-06-12 | 1983-02-10 | METHOD AND COMPOSITION FOR TREATMENT OF ACNE |
DK60083A DK60083A (en) | 1981-06-12 | 1983-02-11 | COSMETIC AGENT FOR THE TREATMENT OF ACNE AND OIL SKIN AND PROCEDURE FOR REMOVING ODOR FROM SUCH A MEDICINE |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27092881A | 1981-06-12 | 1981-06-12 | |
US270928810612 | 1981-06-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1982004393A1 true WO1982004393A1 (en) | 1982-12-23 |
Family
ID=23033426
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1981/001063 WO1982004393A1 (en) | 1981-06-12 | 1981-08-10 | Method and composition for treating acne |
Country Status (22)
Country | Link |
---|---|
US (1) | US4388301A (en) |
EP (1) | EP0081492B1 (en) |
JP (1) | JPS58500897A (en) |
AR (1) | AR227559A1 (en) |
AT (1) | ATA910981A (en) |
AU (1) | AU548845B2 (en) |
BE (1) | BE890648A (en) |
BR (1) | BR8109030A (en) |
CA (1) | CA1185530A (en) |
CH (1) | CH657528A5 (en) |
DE (1) | DE3152893A1 (en) |
DK (1) | DK60083A (en) |
ES (1) | ES506072A0 (en) |
GB (1) | GB2110932B (en) |
IE (1) | IE51641B1 (en) |
IT (1) | IT1144832B (en) |
NL (1) | NL8120306A (en) |
NZ (1) | NZ198575A (en) |
PH (1) | PH20226A (en) |
SE (1) | SE8300718L (en) |
WO (1) | WO1982004393A1 (en) |
ZA (1) | ZA817536B (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0281812A1 (en) * | 1987-02-18 | 1988-09-14 | Milor Scientific, Ltd. | Composition for treatment of acne |
EP0759290A1 (en) * | 1995-08-14 | 1997-02-26 | GEOMEDICAL S.r.l. | Topical aqueous gels or suspensions based on pulverized volcanic or diagenetic minerals |
EP1299068A1 (en) * | 2000-06-30 | 2003-04-09 | Medicis Pharmaceutical | Sulfur containing dermatological compositions and methods for reducing malodors in dermatological compositions |
US6787160B2 (en) | 2000-06-30 | 2004-09-07 | Medicis Pharmaceutical Corporation | Compositions and methods for high sorption of skin materials and delivery of sulfur |
EP1527770A2 (en) * | 2004-04-08 | 2005-05-04 | Mauro Castiglioni | A cosmetic mask composition |
CN100377700C (en) * | 2006-03-07 | 2008-04-02 | 许盛英 | Embossed-rod health-cave bathing-mud powder |
US7479289B2 (en) | 2004-07-02 | 2009-01-20 | Medicis Pharmaceutical Corporation | Stable cleanser compositions containing sulfur |
US7655682B2 (en) | 2004-07-02 | 2010-02-02 | Medicis Pharmaceutical Corporation | Triple anti-irritant composition |
WO2020096600A1 (en) * | 2018-11-08 | 2020-05-14 | Colgate-Palmolive Company | Deodorant compositions |
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JPS61236710A (en) * | 1985-04-12 | 1986-10-22 | Shiseido Co Ltd | Stabilized resorcin compounding agent |
JPS61236709A (en) * | 1985-04-12 | 1986-10-22 | Shiseido Co Ltd | Resorcin compounding agent |
US5716625A (en) * | 1994-12-21 | 1998-02-10 | Cosmederm Technologies | Formulations and methods for reducing skin irritation |
US5756107A (en) * | 1994-12-21 | 1998-05-26 | Cosmederm Technologies | Formulations and methods for reducing skin irritation |
US5804203A (en) * | 1994-12-21 | 1998-09-08 | Cosmederm Technologies | Topical product formulations containing strontium for reducing skin irritation |
US6139850A (en) * | 1994-12-21 | 2000-10-31 | Cosmederm Technologies | Formulations and methods for reducing skin irritation |
US7404967B2 (en) * | 1994-12-21 | 2008-07-29 | Cosmederm, Inc. | Topical product formulations containing strontium for reducing skin irritation |
JP3422468B2 (en) * | 1998-02-24 | 2003-06-30 | 花王株式会社 | Sebum selective removal method |
US6602920B2 (en) * | 1998-11-25 | 2003-08-05 | The Texas A&M University System | Method for converting natural gas to liquid hydrocarbons |
US20020164381A1 (en) * | 2000-06-30 | 2002-11-07 | Medicis Pharmaceutical Corporation | Mitocidal compositions and methods |
US6774100B2 (en) | 2000-12-06 | 2004-08-10 | Imaginative Research Associates, Inc. | Anhydrous creams, lotions and gels |
US6462025B2 (en) | 2000-12-12 | 2002-10-08 | Imaginative Research Associates, Inc. | Antibiotic/benzoyl peroxide dispenser |
US20060189552A1 (en) * | 2000-12-12 | 2006-08-24 | Mohan Vishnupad | Dispenser for dispensing three or more actives |
US7060732B2 (en) * | 2000-12-12 | 2006-06-13 | Imaginative Research Associates, Inc. | Antibiotic/benzoyl peroxide dispenser |
US20030228270A1 (en) * | 2002-06-10 | 2003-12-11 | Erika Tazberik | Foaming clay cleanser composition |
US20040001794A1 (en) * | 2002-06-28 | 2004-01-01 | Withiam Michael C. | Compositions comprising odor neutralizing calcium silicate |
US6977081B1 (en) | 2002-12-18 | 2005-12-20 | Upsher-Smith Laboratories, Inc. | Facial cream composition containing allantoin |
US20050025817A1 (en) * | 2003-07-03 | 2005-02-03 | Bhatia Kuljit S. | Delivery system for topical medications |
US7776355B2 (en) * | 2003-07-03 | 2010-08-17 | Medics Pharmaceutical Corporation | Delivery system for topical medications |
US20050063928A1 (en) * | 2003-09-18 | 2005-03-24 | Withiam Michael C. | Compositions comprising odor neutralizing metal oxide silicates |
ZA200606521B (en) * | 2004-02-06 | 2008-02-27 | Unilever Plc | Improved detergent composition |
US8846063B2 (en) * | 2008-12-16 | 2014-09-30 | Kimberly-Clark Worldwide, Inc. | Personal care composition containing a volatile and a terpene alcohol |
FR3001392B1 (en) | 2013-01-30 | 2015-03-20 | Codexial Dermatologie | IMPROVED DERMATOLOGICAL COMPOSITION |
EP3563825A1 (en) * | 2018-05-02 | 2019-11-06 | The Boots Company plc | Cosmetic skincare composition |
CN110772436B (en) * | 2019-11-05 | 2020-11-20 | 江苏清荷材料科技有限公司 | Skin-care oil-absorbing ball and preparation method thereof |
WO2023186618A1 (en) * | 2022-03-28 | 2023-10-05 | Unilever Ip Holdings B.V. | Composition with enhanced stability and sensory |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1800502A (en) * | 1928-03-20 | 1931-04-14 | Casmer R Brown | Medicine |
US2156790A (en) * | 1937-06-01 | 1939-05-02 | San Francisco Sulphur Company | Wettable sulphur composition |
-
1981
- 1981-08-10 AU AU75316/81A patent/AU548845B2/en not_active Ceased
- 1981-08-10 WO PCT/US1981/001063 patent/WO1982004393A1/en active IP Right Grant
- 1981-08-10 NL NL8120306A patent/NL8120306A/nl unknown
- 1981-08-10 BR BR8109030A patent/BR8109030A/en unknown
- 1981-08-10 CH CH867/83A patent/CH657528A5/en not_active IP Right Cessation
- 1981-08-10 EP EP81902223A patent/EP0081492B1/en not_active Expired
- 1981-08-10 DE DE813152893T patent/DE3152893A1/en not_active Ceased
- 1981-08-10 GB GB08303242A patent/GB2110932B/en not_active Expired
- 1981-08-10 JP JP50278981A patent/JPS58500897A/en active Pending
- 1981-08-10 AT AT0910981A patent/ATA910981A/en not_active Application Discontinuation
- 1981-10-05 CA CA000387264A patent/CA1185530A/en not_active Expired
- 1981-10-06 ES ES506072A patent/ES506072A0/en active Granted
- 1981-10-06 BE BE0/206179A patent/BE890648A/en not_active IP Right Cessation
- 1981-10-07 NZ NZ198575A patent/NZ198575A/en unknown
- 1981-10-08 IT IT68303/81A patent/IT1144832B/en active
- 1981-10-09 IE IE2367/81A patent/IE51641B1/en unknown
- 1981-10-12 PH PH26337A patent/PH20226A/en unknown
- 1981-10-12 AR AR237061A patent/AR227559A1/en active
- 1981-10-30 ZA ZA817536A patent/ZA817536B/en unknown
-
1982
- 1982-04-30 US US06/373,442 patent/US4388301A/en not_active Expired - Fee Related
-
1983
- 1983-02-10 SE SE8300718A patent/SE8300718L/en not_active Application Discontinuation
- 1983-02-11 DK DK60083A patent/DK60083A/en not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1800502A (en) * | 1928-03-20 | 1931-04-14 | Casmer R Brown | Medicine |
US2156790A (en) * | 1937-06-01 | 1939-05-02 | San Francisco Sulphur Company | Wettable sulphur composition |
Non-Patent Citations (2)
Title |
---|
"Encyclopedia of Chemical Technology", 1964, KIRK-OTHMER, INTERSCIENCE PUBLISHERS * |
"Handbook of Non-Prescription Drugs", 1977, AMERICAN PHARMACEUTICAL ASSOCIATION, pages: 317 - 323 * |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0281812A1 (en) * | 1987-02-18 | 1988-09-14 | Milor Scientific, Ltd. | Composition for treatment of acne |
EP0759290A1 (en) * | 1995-08-14 | 1997-02-26 | GEOMEDICAL S.r.l. | Topical aqueous gels or suspensions based on pulverized volcanic or diagenetic minerals |
EP2020256A1 (en) * | 2000-06-30 | 2009-02-04 | Medicis Pharmaceutical Corporation | Sulfur containing dermatological compositions |
EP1299068A1 (en) * | 2000-06-30 | 2003-04-09 | Medicis Pharmaceutical | Sulfur containing dermatological compositions and methods for reducing malodors in dermatological compositions |
US6787160B2 (en) | 2000-06-30 | 2004-09-07 | Medicis Pharmaceutical Corporation | Compositions and methods for high sorption of skin materials and delivery of sulfur |
US6855342B2 (en) | 2000-06-30 | 2005-02-15 | Medicis Pharmaceutical Corporation | Compositions and methods for high sorption of skin materials and delivery of sulfur |
EP1299068A4 (en) * | 2000-06-30 | 2003-09-24 | Medicis Pharmaceutical | Sulfur containing dermatological compositions and methods for reducing malodors in dermatological compositions |
US6905675B2 (en) | 2000-06-30 | 2005-06-14 | Medicis Pharmaceutical Corporation | Sulfur containing dermatological compositions and methods for reducing malodors in dermatological compositions |
US6955825B2 (en) | 2000-06-30 | 2005-10-18 | Medicis Pharmaceutical Corporation | Compositions and methods for high sorption of skin materials and delivery of sulfur |
EP1527770A3 (en) * | 2004-04-08 | 2005-09-07 | Mauro Castiglioni | A cosmetic mask composition |
EP1527770A2 (en) * | 2004-04-08 | 2005-05-04 | Mauro Castiglioni | A cosmetic mask composition |
US7479289B2 (en) | 2004-07-02 | 2009-01-20 | Medicis Pharmaceutical Corporation | Stable cleanser compositions containing sulfur |
US7655682B2 (en) | 2004-07-02 | 2010-02-02 | Medicis Pharmaceutical Corporation | Triple anti-irritant composition |
US7674812B2 (en) | 2004-07-02 | 2010-03-09 | Medicis Pharmaceutical Corp. | Triple anti-irritant composition |
CN100377700C (en) * | 2006-03-07 | 2008-04-02 | 许盛英 | Embossed-rod health-cave bathing-mud powder |
WO2020096600A1 (en) * | 2018-11-08 | 2020-05-14 | Colgate-Palmolive Company | Deodorant compositions |
CN112955111A (en) * | 2018-11-08 | 2021-06-11 | 高露洁-棕榄公司 | Deodorant composition |
Also Published As
Publication number | Publication date |
---|---|
NZ198575A (en) | 1985-04-30 |
DK60083D0 (en) | 1983-02-11 |
EP0081492A4 (en) | 1984-01-09 |
ES8301624A1 (en) | 1983-01-01 |
JPS58500897A (en) | 1983-06-02 |
GB2110932A (en) | 1983-06-29 |
AU548845B2 (en) | 1986-01-02 |
AR227559A1 (en) | 1982-11-15 |
GB8303242D0 (en) | 1983-03-09 |
ATA910981A (en) | 1988-06-15 |
AU7531681A (en) | 1983-01-04 |
BE890648A (en) | 1982-02-01 |
IT1144832B (en) | 1986-10-29 |
EP0081492B1 (en) | 1986-07-16 |
BR8109030A (en) | 1983-05-10 |
NL8120306A (en) | 1983-05-02 |
GB2110932B (en) | 1985-08-07 |
IT8168303A0 (en) | 1981-10-08 |
EP0081492A1 (en) | 1983-06-22 |
SE8300718D0 (en) | 1983-02-10 |
IE812367L (en) | 1982-12-12 |
ES506072A0 (en) | 1983-01-01 |
SE8300718L (en) | 1983-02-10 |
DE3152893A1 (en) | 1983-06-16 |
CA1185530A (en) | 1985-04-16 |
ZA817536B (en) | 1982-10-27 |
CH657528A5 (en) | 1986-09-15 |
PH20226A (en) | 1986-10-23 |
US4388301A (en) | 1983-06-14 |
IE51641B1 (en) | 1987-01-21 |
DK60083A (en) | 1983-02-11 |
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