WO1979000401A1 - Anti-tumor agent - Google Patents
Anti-tumor agent Download PDFInfo
- Publication number
- WO1979000401A1 WO1979000401A1 PCT/JP1978/000055 JP7800055W WO7900401A1 WO 1979000401 A1 WO1979000401 A1 WO 1979000401A1 JP 7800055 W JP7800055 W JP 7800055W WO 7900401 A1 WO7900401 A1 WO 7900401A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tumor agent
- vitamin
- acid ester
- tumor
- alphatocopherol
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 229960005280 isotretinoin Drugs 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15062677A JPS5484034A (en) | 1977-12-16 | 1977-12-16 | Anti-tumor agent |
JP77/150626 | 1977-12-16 | ||
JP15763077A JPS6056156B2 (ja) | 1977-12-29 | 1977-12-29 | α‐トコフエロ−ル‐13‐cis‐ビタミンA酸エステル |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1979000401A1 true WO1979000401A1 (en) | 1979-07-12 |
Family
ID=26480167
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1978/000055 WO1979000401A1 (en) | 1977-12-16 | 1978-12-14 | Anti-tumor agent |
Country Status (3)
Country | Link |
---|---|
US (1) | US4320141A (ja) |
EP (1) | EP0008573A1 (ja) |
WO (1) | WO1979000401A1 (ja) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5039699A (en) * | 1989-03-27 | 1991-08-13 | Lederle (Japan), Ltd. | Anti-peptic ulcer agent |
EP0636618A1 (de) * | 1991-06-04 | 1995-02-01 | Marigen S.A. | Spontan dispergierbare Konzentrate und Mikroemulsionen mit Vitamin-E-Verbindungen zur Herstellung von Arzneimitteln mit Antitumoraler Wirksamkeit |
CH681152A5 (de) * | 1991-06-04 | 1993-01-29 | Marigen S.A. | Neue biotenside und antitumorale ester und phosphatide mit vitamin-d- und vitamin-e-verbindungen, ihre herstellung und aufarbeitung zu spontan dispergierbaren konzentraten. |
US5502224A (en) * | 1991-06-04 | 1996-03-26 | Marigen, S.A. | Biotenside esters and phosphatides with vitamin-D and vitamin-E compounds |
DE69706241T2 (de) * | 1996-07-01 | 2001-12-06 | Nisshin Flour Milling Co | Pharmazeutische Zusammensetzung zur Behandlung der Leukämie enthaltend 9-cis-Retinoinsäure-alpha-Tocopherolester |
IL142082A (en) * | 1998-09-23 | 2005-12-18 | Res Dev | Tocoflowers, tocotrinols, derivatives as a novel and other side-chain and their uses |
US6703384B2 (en) | 1998-09-23 | 2004-03-09 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
KR100847678B1 (ko) * | 2000-02-11 | 2008-07-23 | 리서치 디벨럽먼트 파운데이션 | 토코페롤, 토코트리에놀, 다른 크로만 및 측쇄 유도체, 및이들의 용도 |
US20030236301A1 (en) * | 2001-12-19 | 2003-12-25 | Bob Sanders | Liposomal delivery of vitamin E based compounds |
CA2543722C (en) * | 2003-10-29 | 2011-01-04 | Sonus Pharmaceuticals, Inc. | Tocopherol-modified therapeutic drug compounds |
WO2023023044A1 (en) * | 2021-08-17 | 2023-02-23 | Conagen Inc. | Esters of a retinoid and tocopherol or tert-butylhydroquinone and preparations thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4926632A (ja) * | 1971-06-11 | 1974-03-09 | ||
JPS4931645A (ja) * | 1972-07-24 | 1974-03-22 | ||
US3878202A (en) * | 1971-05-17 | 1975-04-15 | Nisshin Flour Milling Co | Vitamin a-acid esters of {60 -tocopherol and preparation thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2231125A (en) * | 1938-08-10 | 1941-02-11 | Hoffmann La Roche | Esters of tocopherols |
US3151127A (en) * | 1963-09-17 | 1964-09-29 | Int Latex Corp | Tocopherol ascorbates |
-
1978
- 1978-12-14 US US06/154,415 patent/US4320141A/en not_active Expired - Lifetime
- 1978-12-14 EP EP79900025A patent/EP0008573A1/en not_active Withdrawn
- 1978-12-14 WO PCT/JP1978/000055 patent/WO1979000401A1/ja unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3878202A (en) * | 1971-05-17 | 1975-04-15 | Nisshin Flour Milling Co | Vitamin a-acid esters of {60 -tocopherol and preparation thereof |
JPS4926632A (ja) * | 1971-06-11 | 1974-03-09 | ||
JPS4931645A (ja) * | 1972-07-24 | 1974-03-22 |
Also Published As
Publication number | Publication date |
---|---|
EP0008573A1 (en) | 1980-03-05 |
US4320141A (en) | 1982-03-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CS222257B2 (en) | Antimicrobial means and method of making the active component | |
AU514565B2 (en) | Preservation of low acid foods | |
AU514686B2 (en) | Herbicidal compositions and herbicidal processes | |
AU513292B2 (en) | Radar performance monitor | |
CS188140B2 (en) | Herbicide agent and method of preparation of the active agent | |
WO1979000401A1 (en) | Anti-tumor agent | |
AU511736B2 (en) | Enzymatically active substance | |
AU514122B2 (en) | Leavening acid compositions | |
AU5732680A (en) | N,n-disubstituted ethylglycine esters and thiol-esters | |
AU518375B2 (en) | Ester of mm4550, mm13902 and mm17880 | |
ZA775854B (en) | Novel n,n-dimethyl-o-pyrazolyl-carbamic acid esters and their use as insecticides | |
AU4276578A (en) | Phosphoric and thiophosphoric esters of 5(3)-hydroxypyrazolesexerting an insecticide action, intermediate 5(3)-hydro- xpyrazoles | |
NZ186397A (en) | Pharmaceutical compositions 8h-indeno (2,1-b)thiophen-2-oxaminic acids and esters and | |
ZA786637B (en) | Novel n,n-dialkyl-o-pyrimidinyl-carbamic acid esters and their use as insecticides | |
AU515147B2 (en) | Itn-dialkyl-0-pyrimidinyl-carbamic acid esters and their use as arthropodicides | |
IL50594A0 (en) | O,o-diethyl-o-(n-methoxy-2-nitrobenzimidoyl)thionophosphoric acid ester its preparation and its use as an insecticide and acaricide | |
GB1542752A (en) | N,n-dimethyl-o-pyrazolyl-carbamic acid esters and their use as insecticides | |
GB2037289B (en) | Nucleoside derivatives and an antileukemial agent containing the same as an active ingredient | |
JPS5329938A (en) | Carcinostatic agent | |
AU510109B2 (en) | (thio)phosphoric acid esters and their use as herbicides | |
IE40890L (en) | Pyrimidin (2) yl- thionophosphoric acid esters; insecticides | |
JPS5391123A (en) | Antibacterials | |
GB1523000A (en) | (thio) phosphoric acid esters and their use as herbicides | |
AU502739B2 (en) | Biologically active compounds and compositions | |
AU507702B2 (en) | Trans-octahydro-pyrido-benzazepine-3-alkanols-alkanonitriles,-alkanic acid and ester astranquilizer |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Designated state(s): US |
|
AL | Designated countries for regional patents |
Designated state(s): DE FR GB |