UST102907I4 - Process to 3-phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate - Google Patents

Process to 3-phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate Download PDF

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UST102907I4
UST102907I4 US06/381,997 US38199782A UST102907I4 US T102907 I4 UST102907 I4 US T102907I4 US 38199782 A US38199782 A US 38199782A US T102907 I4 UST102907 I4 US T102907I4
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lower alkyl
dichlorovinyl
product
dimethylcyclopropanecarboxylate
phenoxybenzyl
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US06/381,997
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Marc Halfon
William G. Scharpf
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Abstract

3-Phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate is prepared in greater than 90% yield by alcoholysis of lower alkyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylates with 3-phenoxybenzyl alcohol. A lower alkyl alcohol, e.g., methanol or ethanol, is generated as a by-product.
The process is conducted under reflux at a temperature of at least 100° C. in an inert solvent between approximately stoichiometric amounts of the reactants. The solvent is selected to form an azeotropic mixture with, or boil at a higher temperature than, the lower alkyl alcohol by-product, and the by-product is removed from the mixture by distillation as it is produced. If lower alkyl is methyl or ethyl, n-octane, benzene, toluene, xylene, or mesitylene may be employed, for example.
The process is promoted by lower alkyl titanium alkoxide catalysts. The purity of the product 3-phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate, which is obtained as a bottoms residue after stripping the solvent, is high enough, greater than 90%, to be suitable for use in commerce as the pyrethroid insecticide "permethrin" without further purification. The purity is enhanced by the use of only 0.001-0.01 mole of the catalyst per mole of lower alkyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate. To avoid hydrolysis of the catalyst, the reaction is carried out under substantially anhydrous conditions.
US06/381,997 1979-02-07 1982-05-25 Process to 3-phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate Pending UST102907I4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US06/381,997 UST102907I4 (en) 1979-02-07 1982-05-25 Process to 3-phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1018379A 1979-02-07 1979-02-07
US06/381,997 UST102907I4 (en) 1979-02-07 1982-05-25 Process to 3-phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate

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US1018379A Continuation 1979-02-07 1979-02-07

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UST102907I4 true UST102907I4 (en) 1983-04-05

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US06/381,997 Pending UST102907I4 (en) 1979-02-07 1982-05-25 Process to 3-phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate

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