UST102303I4 - 5,6,7,8-Tetrahydrotriazolo{4,3-alpha}-pyridin-3(2H)-ones - Google Patents
5,6,7,8-Tetrahydrotriazolo{4,3-alpha}-pyridin-3(2H)-ones Download PDFInfo
- Publication number
- UST102303I4 UST102303I4 US06/271,296 US27129681A UST102303I4 US T102303 I4 UST102303 I4 US T102303I4 US 27129681 A US27129681 A US 27129681A US T102303 I4 UST102303 I4 US T102303I4
- Authority
- US
- United States
- Prior art keywords
- tetrahydrotriazolo
- carbon atoms
- pyridin
- alkylene chain
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 101100386054 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) CYS3 gene Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000049 anti-anxiety effect Effects 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 230000000561 anti-psychotic effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000009533 lab test Methods 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 101150035983 str1 gene Proteins 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
5,6,7,8-Tetrahydrotriazolo{4,3-a}pyridin-3(2H)-one derivatives containing a 4-(optionally substituted phenyl)piperazinyl component attached to the 2- position of the tetrahydrotriazolo{4,3-a}pyridinone component via an alkylene chain of 3 or 4 carbon atoms are disclosed. Examples are compounds having the formula ##STR1## wherein R is lower alkyl or alkoxy (each having 1 to 4 carbon atoms inclusive), cyano, halogen, or trifluoromethyl; and Y is an alkylene chain of 3 or 4 carbon atoms. The compound in which R is 3-Cl and Y is trimethylene exhibits central nervous system pharmacological properties in standard laboratory tests which are predictive of useful anti-psychotic, antidepressant, and antianxiety action.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/271,296 UST102303I4 (en) | 1981-06-08 | 1981-06-08 | 5,6,7,8-Tetrahydrotriazolo{4,3-alpha}-pyridin-3(2H)-ones |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/271,296 UST102303I4 (en) | 1981-06-08 | 1981-06-08 | 5,6,7,8-Tetrahydrotriazolo{4,3-alpha}-pyridin-3(2H)-ones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UST102303I4 true UST102303I4 (en) | 1982-10-05 |
Family
ID=23034989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US06/271,296 Pending UST102303I4 (en) | 1981-06-08 | 1981-06-08 | 5,6,7,8-Tetrahydrotriazolo{4,3-alpha}-pyridin-3(2H)-ones |
Country Status (1)
| Country | Link |
|---|---|
| US (1) | UST102303I4 (en) |
-
1981
- 1981-06-08 US US06/271,296 patent/UST102303I4/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| STPP | Information on status: patent application and granting procedure in general |
Free format text: DEFENSIVE PUBLICATION OR SIR FILE |