UST100505I4 - Triazolo[4,3-a]pyridin-3(2H)-ones - Google Patents

Triazolo[4,3-a]pyridin-3(2H)-ones Download PDF

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Publication number
UST100505I4
UST100505I4 US06/130,900 US13090080A UST100505I4 US T100505 I4 UST100505 I4 US T100505I4 US 13090080 A US13090080 A US 13090080A US T100505 I4 UST100505 I4 US T100505I4
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Prior art keywords
triazolo
och
compounds
pyridin
divalent
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Pending
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US06/130,900
Inventor
Duane F. Morrow
Yao H. Wu
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Priority to US06/130,900 priority Critical patent/UST100505I4/en
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Publication of UST100505I4 publication Critical patent/UST100505I4/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Triazolo[4,3-a]pyridin-3-(2H)-one derivatives containing a 4-(optionally substituted phenyl)piperazinyl component attached to the two position of the triazolo-[4,3-a]pyridine component via a divalent radical such as --(CH2)5 --, --(CH2)6 --, --CH3 CH(CH3)CH2 --, --CH2 C(CH3)2 CH2 --, --CH2 CH═CHCH2 --, --CH2 C.tbd.CCH2 --, --CH2 CH2 OCH2 CH2 -- or a divalent cycloalkylene radical of 3 to 6 carbon atoms are disclosed. The compounds are useful in that they exhibit central nervous system pharmacological properties in standard laboratory tests considered predictive of analgetics, anti-psychotic (neuroleptics), antidepressant and antianxiety utility. Examples of specific embodiments of the invention are compounds having the formula
______________________________________
##STR1## Y R ______________________________________ ##STR2## 3-Cl ##STR3## H ##STR4## 3-Cl ##STR5## 3-CF3 ##STR6## 4-F CH2 CHCHCH2 3-Cl CH2 CCCH2 3-Cl (CH2)5 3-Cl (CH2)5 4-CH3 O (CH2)5 2-CH3 (CH2)6 3-Cl CH2 C(CH3)2 CH2 3-Cl CH2 CH(CH3)CH2 3-CF3 CH2 CH2 OCH2 CH2 3-Cl ______________________________________
US06/130,900 1980-03-17 1980-03-17 Triazolo[4,3-a]pyridin-3(2H)-ones Pending UST100505I4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US06/130,900 UST100505I4 (en) 1980-03-17 1980-03-17 Triazolo[4,3-a]pyridin-3(2H)-ones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/130,900 UST100505I4 (en) 1980-03-17 1980-03-17 Triazolo[4,3-a]pyridin-3(2H)-ones

Publications (1)

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UST100505I4 true UST100505I4 (en) 1981-04-07

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US06/130,900 Pending UST100505I4 (en) 1980-03-17 1980-03-17 Triazolo[4,3-a]pyridin-3(2H)-ones

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4402956A (en) 1980-04-09 1983-09-06 Aziende Chimiche Riunite Angelini Francesco Acraf Spa 2-[3-[4-(3-Chloro-4-fluorophenyl)-1-piperazinyl]propyl]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one
US5622951A (en) * 1993-01-06 1997-04-22 John Wyeth & Brother Ltd. Piperazine derivatives as 5-HT antagonists
US5726178A (en) * 1992-01-17 1998-03-10 Istituto Ricerca Francesco Angelini S.P.A. Alkyl derivatives of trazodone with CNS activity

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4402956A (en) 1980-04-09 1983-09-06 Aziende Chimiche Riunite Angelini Francesco Acraf Spa 2-[3-[4-(3-Chloro-4-fluorophenyl)-1-piperazinyl]propyl]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one
US5726178A (en) * 1992-01-17 1998-03-10 Istituto Ricerca Francesco Angelini S.P.A. Alkyl derivatives of trazodone with CNS activity
US5739334A (en) * 1992-01-17 1998-04-14 Istituto Ricerca Francesco Angelini S.P.A. Alkyl derivatives of trazodone with CNS activity
US5622951A (en) * 1993-01-06 1997-04-22 John Wyeth & Brother Ltd. Piperazine derivatives as 5-HT antagonists

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