USRE46365E1 - 6,7-unsaturated-7-carbamoyl substituted morphinan derivative - Google Patents

6,7-unsaturated-7-carbamoyl substituted morphinan derivative Download PDF

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USRE46365E1
USRE46365E1 US15/064,511 US200615064511A USRE46365E US RE46365 E1 USRE46365 E1 US RE46365E1 US 200615064511 A US200615064511 A US 200615064511A US RE46365 E USRE46365 E US RE46365E
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compound
optionally substituted
lower alkyl
pharmaceutically acceptable
acceptable salt
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Masanao Inagaki
Shin-ichiro Hara
Nobuhiro Haga
Yoshinori Tamura
Yoshihisa Goto
Tsuyoshi Hasegawa
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Shionogi and Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A novel compound which is useful as an agent for treating and/or preventing emesis, vomiting and/or constipation. A compound represented by the formula (I):
Figure USRE046365-20170411-C00001
    • wherein R1 and R2 are each independently hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted cycloalkyl, optionally substituted aryl etc., R3 is hydrogen, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted lower alkoxy etc., R4 is hydrogen or lower alkyl, R5 is hydrogen, lower alkyl, cycloalkyl lower alkyl or lower alkenyl, or a pharmaceutically acceptably salt, or a solvate thereof is provided.

Description

This application is a 371 national phase filing of International Application No. PCT/JP2006/310454, filed May 25, 2006, now International Publication No. WO 2006/126637, which claims priority from Japanese Patent Application No. 2005-151864, filed May 25, 2005, Japanese Patent Application No. 2006-065762, filed Mar. 10, 2006, and International Application No. PCT/JP2006/310231, filed May 23, 2006, now International Publication No. WO 2006/126529, each of which are herein incorporated by reference for all purposes.
This application is a reissue application of U.S. Pat. No. 8,084,460, issued on Dec. 27, 2011 from U.S. patent application Ser. No. 11/920,851, which is the National Stage Entry of International Application No. PCT/JP2006/310454, filed May 25, 2006, which claims the benefit of priority of Japan Application No. 2005-151864, filed on May 25, 2005, Japan Application No. 2006-065762, filed Mar. 10, 2006, and International Application No. PCT/JP2006/310231, filed May 23, 2006, all of which are incorporated herein by reference in their entirety.
TECHNICAL FIELD
The present invention relates to a 6,7-unsaturated-7-carbamoyl-substituted morphinan derivatives, which are useful as an agent for treating and/or preventing nausea, emesis, vomiting and/or constipation, particularly as an agent for alleviating and/or preventing a side effect (emesis, vomiting and/or constipation etc.) induced by a compound having the opioid receptor (e.g. opioid μ receptor) agonistic activity.
BACKGROUND ART
An opioid receptor agonist such as morphine and the like which is used as an analgesic is very effective in a patient having cancer pain, but as a side effect, induces severe nausea, emesis, vomiting, constipation, anuresis, and itching. Various antiemetics and anti-constipation agents are clinically used, but it can not be said that any of them exhibits the sufficient effect, and an excellent side effect alleviating agent is also demanded for improving QOL of a patient.
Patent Literatures 1 and 2, and Non-patent Literature 1 describe to the effect that a morphinan derivative is effective in treating or preventing emesis and vomiting induced by an opioid μ agonist, and Non-Patent Literature 2 describes that a 6,7-saturated-7-carbamoyl-substituted-morphinan derivatives have the opioid δ receptor antagonism. However, none of them describes or suggests the present compound.
  • [Patent Literature 1] International Patent Application Publication WO 2004-007503
  • [Patent Literature 2] International Patent Application Publication WO 95/13071
  • [Non-Patent Literature 1] Journal of Medicinal Chemistry 41, 4177-4180 (1998)
  • [Non-Patent Literature 2] Chemical and Pharmaceutical Bulletin, 52 (66) 747-750 (2004)
DISCLOSURE OF INVENTION Problems to be Solved by the Invention
We found 6,7-unsaturated-7-carbamoyl-substituted morphinan derivatives useful as a composition for treating and/or preventing emesis, vomiting and/or constipation.
Means to Solve the Problems
The present invention provides:
  • (1) a compound represented by the formula (I):
Figure USRE046365-20170411-C00002
  • wherein R1 and R2 are each independently hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted lower alkylsulfonyl, optionally substituted acyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl, an optionally substituted heterocyclic group, or optionally substituted arylsulfonyl, or R1 and R2 are taken together with the nitrogen atom to which they are attached to form optionally substituted heterocycle;
  • R3 is hydrogen, hydroxy, optionally substituted lower alkyl, lower optionally substituted lower alkenyl, optionally substituted lower alkynyl optionally substituted lower alkoxy, mercapto, optionally substituted lower alkylthio, optionally substituted amino, optionally substituted carbamoyl, optionally substituted acyl, optionally substituted acyloxy, optionally substituted aryl, or an optionally substituted heterocyclic group,
  • a group represented by the formula:
Figure USRE046365-20170411-C00003
  • wherein ring A or ring B are each independently optionally substituted nitrogen-containing heterocycle optionally containing additional nitrogen atom, an oxygen atom, and/or a sulfur atom in the ring;
  • broken line indicates the presence or the absence of a bond;
  • when a broken line indicates the presence of a bond, p is 0;
  • when a broken line indicates the absence of a bond, p is 1;
  • Ra is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, or optionally substituted lower alkynyl;
  • and Rb is hydrogen or oxo;
  • R4 is hydrogen or lower alkyl;
  • R5 is hydrogen, lower alkyl, cycloalkyl lower alkyl or lower alkenyl,
  • or a pharmaceutically acceptable salt, or a solvate thereof,
  • (1′) a compound represented by the formula (I):
Figure USRE046365-20170411-C00004
  • wherein R1 and R2 are each independently hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted cycloalkyl, optionally substituted aryl, or an optionally substituted heterocyclic group, or R1 and R2 are taken together with the nitrogen atom to which they are attached to form optionally substituted heterocycle;
  • R3 is hydrogen, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted lower alkoxy, mercapto, optionally substituted lower alkylthio, optionally substituted aryl, or an optionally substituted heterocyclic group;
  • R4 is hydrogen or lower alkyl;
  • and R5 is hydrogen, lower alkyl, cycloalkyl lower alkyl or lower alkenyl;
  • or a pharmaceutically acceptable salt, or a solvate thereof,
  • (2) the compound according to (1) or (1′), wherein R3 is hydroxy,
  • or a pharmaceutically acceptable salt, or a solvate thereof,
  • (3) the compound according to (1) or (1′), wherein R3 is optionally substituted amino,
  • or a pharmaceutically acceptable salt, or a solvate thereof,
  • (4) the compound according to (1) or (1′), wherein R3 is amino substituted with optionally substituted arylsulfonyl,
  • or a pharmaceutically acceptable salt, or a solvate thereof,
  • (5) the compound according to any one of (1) to (4), and (1′), wherein R1 is hydrogen or lower alkyl, R2 is optionally substituted lower alkyl, optionally substituted phenyl, optionally substituted cycloalkyl, or an optionally substituted heterocyclic group, and R5 is cyclopropylmethyl;
  • or a pharmaceutically acceptable salt, or a solvate thereof,
  • (6) the compound according to any of (1) to (5), and (1′), wherein R1 is hydrogen, R2 is lower alkyl optionally substituted with lower alkoxy or with a heterocyclic group that is optionally substituted with aryl, phenyl optionally substituted with lower alkyl or with lower alkoxy, cycloalkyl substituted with lower alkylcarbonyl, or a heterocyclic group substituted with lower alkoxy or with aryl, R4 is hydrogen, and R5 is cyclopropylmethyl, or a pharmaceutically acceptable salt, or a solvate thereof.
  • (7) a pharmaceutical composition containing the compound according to any one of (1) to (6), and (1′), or a pharmaceutically acceptable salt, or a solvate thereof,
  • (8) a composition having opioid receptor antagonistic activity containing the compound according to (1) to (6), and (1′), or a pharmaceutically acceptable salt, or a solvate thereof,
  • (9) a composition for treating and/or preventing emesis, vomiting and/or constipation containing the compound according to any one of (1) to (6), and
  • (1′), or a pharmaceutically acceptable salt, or a solvate thereof,
  • (10) a composition for alleviating and/or preventing a side effect induced by a compound having the opioid receptor agonistic activity, containing the compound according to any one of (1) to (6), and (1′), or a pharmaceutically acceptable salt, or a solvate thereof,
  • (11) a composition for treatment and/or prevention according to (10), wherein the side effect is emesis, vomiting and/or constipation,
  • (12) an agent for treatment and/or prevention according to (10) or (11), wherein the compound having the opioid receptor agonistic activity is morphine, oxycodone, or a pharmaceutically acceptable salt, or a solvate thereof,
  • (13) use of the compound according to any one of (1) to (6), and (1′), or a pharmaceutically acceptable salt, or solvate thereof for producing a medicament for treating and/or preventing emesis, vomiting and/or constipation,
  • (14) use of the compound according to any one of (1) to (6), and (1′), or a pharmaceutically acceptable salt, or solvate thereof, for producing a medicament for alleviating and/or preventing a side effect induced by a compound having the opioid receptor agonistic activity,
  • (15) a method for treating and/or preventing emesis, vomiting and/or constipation, comprising administering the compound according to any one of (1) to (6) and (1′), or a pharmaceutically acceptable salt, or a solvate thereof,
  • (16) a method for alleviating and/or preventing a side effect induced by a compound having the opioid receptor agonistic activity, comprising administering the compound according to any one of (1) to (6) and (1′), its pharmaceutically acceptable salt, or a solvate thereof,
  • (17) a composition for analgesic containing
  • a compound having an opioid receptor agonistic activity,
  • and an effective amount of compound according to any one of (1) to (6) and (1′),
  • or a pharmaceutically acceptable salt, or a solvate thereof, for alleviating and/or preventing a side effect induced by administration of the compound having an opioid receptor agonistic activity,
  • (18) a composition for analgesic containing
  • a compound having an opioid receptor agonistic activity,
  • and an effective amount of compound according to any one of (1) to (6) and (1′),
  • or a pharmaceutically acceptable salt or a solvate thereof, for treating and/or preventing emesis, vomiting and/or constipation induced by administration of the compound having an opioid receptor agonistic activity,
  • (19) the analgesic according to (17) or (18), wherein the compound having the opioid receptor agonistic activity, is morphine, oxycodone, its pharmaceutically acceptable salt, or a solvate thereof.
EFFECT OF THE INVENTION
The compound (I) of the present invention has the activity of treating/or preventing emesis, vomiting and/or constipation, particularly emesis, vomiting and/or constipation induced by a compound having the opioid receptor (e.g. opioid μ receptor) agonistic activity, and is useful as a composition for alleviating a side effect of a patient to whom a compound having the opioid receptor agonistic activity is administered or is in the middle of administration.
BEST MODE FOR CARRYING OUT THE INVENTION
As used herein, the “halogen” includes fluorine, chlorine, bromine and iodine. A halogen part of the “halogeno lower alkyl”, the “halogeno lower alkoxy”, and the “halogeno lower alkylthio” is the same.
The “lower alkyl” includes a straight or branched alkyl of a carbon number of 1 to 10, preferably a carbon number of 1 to 6, further preferably 1 to 3, and examples include methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, isopentyl, neopentyl, hexyl, isohexyl, n-heptyl, isoheptyl, n-octyl, isooctyl, n-nonyl and n-decyl. Preferable are methyl, ethyl, isopropyl, n-butyl, sec-butyl, tert-butyl, and 1-ethylpropyl.
Examples of a substituent of the “optionally substituted lower alkyl”include halogen, hydroxy, lower alkoxy, halogeno lower alkoxy, hydroxy lower alkoxy, lower alkylthio, lower alkylamino, acylamino, acyl, acyloxy, cyano, carboxy, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl, cyanocarbamoyl, lower alkylsulfonylcarbamoyl, arylsulfonylcarbamoyl, sulfamoyl, lower alkylsulfamoyl, lower alkylsulfonyl, cycloalkyl optionally substituted with one or more substituents selected from Substituent group α(wherein Substituent group α is halogen, hydroxy, lower alkyl, halogeno lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, carboxy lower alkyl, lower alkoxycarbonyl lower alkyl, amino lower alkyl, lower alkylamino lower alkyl, acylamino lower alkyl, cyano lower alkyl, lower alkoxy, halogeno lower alkoxy, hydroxy lower alkoxy, lower alkylthio, halogeno lower alkylthio, acyl, acyloxy, amino, lower alkylamino, acylamino, cyano, carboxy, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl, arylcarbamoyl, cyanocarbamoyl, lower alkylsulfonylcarbamoyl, sulfamoyl, lower alkylsulfamoyl, lower alkylsulfonyl, aryl optionally substituted with lower alkylenedioxy, and a heterocyclic group), cycloalkenyl optionally substituted with one or more substituents selected from Substituent group α, aryl optionally substituted with one or more substituents selected from Substituent group α, aryloxy optionally substituted with one or more substituents selected from Substituent group α, arylthio optionally substituted with one or more substituents selected from Substituent group α, a heterocyclic group optionally substituted with one or more substituents selected from Substituent group α, and heterocyclic oxy optionally substituted with one or more substituents selected from Substituent group α.
A lower alkyl part of the “halogeno lower alkyl”, the “hydroxy lower alkyl”, the “amino lower alkyl”, the “acylamino lower alkyl”, the “acyloxy lower alkyl”, the “cycloalkyl lower alkyl”, the “lower alkoxy”, the “halogeno lower alkoxy”, the “hydroxy lower alkoxy”, the “lower alkoxy lower alkyl”, the “lower alkoxycarbonyl”, the “carboxy lower alkyl”, the “lower alkoxycarbonyl lower, alkyl”, the “lower alkylthio”, the “halogeno lower alkylthio”, the “lower alkylamino”, the “lower alkylamino lower alkyl”, the “lower alkylcarbamoyl”, the “lower alkylsulfamoyl”, the “lower alkylsulfonyl”, the “aryl lower alkyl”, the “tri lower alkylsilyl”, the “lower alkyldiarylsilyl”, the “triaryl lower alkylsilyl”, the “lower alkoxy lower alkoxy lower alkyl”, the “lower alkylthio lower alkyl”, the “aryl lower alkoxy lower alkyl”, the “lower alkylsulfonyl”, the “lower alkylsulfonylcarbamoyl”, the “lower alkylcarbonyl”, the “cyano lower alkyl”, the “lower alkoxycarbonylamino”, the “lower alkylenedioxy”, and the “heterocyclic lower alkyl” is the same as that of the aforementioned “lower alkyl”.
A substituent of the “optionally substituted lower alkoxy”, the “optionally substituted lower alkylthio”, and the “optionally substituted lower alkylsulfonyl” is the same as the aforementioned substituent of the “optionally substituted lower alkyl”.
The “lower alkenyl” includes a straight or branched alkenyl of a carbon number of 2 to 10, preferably a carbon number of 2 to 8, further preferably a carbon number of 3 to 6 having one or more double bonds at an arbitrary position. Specifically, examples include vinyl, allyl, propenyl, isopropenyl, butenyl, isobutenyl, prenyl, butadienyl, pentenyl, isopentenyl, pentadienyl, hexenyl, isohexenyl, hexadienyl, heptenyl, octenyl, nonenyl and decenyl. The lower alkenyl in R5 is preferably allyl.
The substituent of the “optionally substituted lower alkenyl” is the same as that of the “optionally substituted lower alkyl”.
The “lower alkynyl” includes straight or branched alkynyl of a carbon number of 2 to 10, preferably a carbon number of 2 to 8, further preferably a carbon number of 3 to 6 having one or more triple bonds at an arbitrary position. Specifically, examples include ethynyl, propynyl, butynyl, pentynyl, hexynyl, heptynyl, octynyl, nonynyl, and decynyl. These may further have a double bond at an arbitrary position.
The substituent of the “optionally substituted lower alkynyl” is the same as that of the “optionally substituted lower alkyl”.
Examples of the substituent of the “optionally substituted amino”include lower alkyl optionally substituted with one or more substituents selected from Substituent group α, cycloalkyl optionally substituted with one or more substituents selected from Substituent group α, acyl optionally substituted with one or more substituents selected from Substituent group α, amino optionally substituted with one or more substituents selected from Substituent group α, aryl optionally substituted with one or more substituents selected from Substituent group α, sulfamoyl, lower alkylsulfamoyl optionally substituted with one or more substituents selected from Substituent group α, arylsulfamoyl optionally substituted with one or more substituents selected from Substituent group α, lower alkylsulfonyl optionally substituted with one or more substituents selected from Substituent group α, arylsulfonyl optionally substituted with one or more substituents selected from Substituent group α, arylamino optionally substituted with one or more substituents selected from Substituent group α, and a heterocyclic group optionally substituted with one or more substituents selected from Substituent group α.
The substituent of the “optionally substituted carbamoyl” is the same as that of the “optionally substituted amino”.
The “cycloalkyl” is a carbocyclic group of a carbon number of 3 to 10, preferably a carbon number of 3 to 8, more preferably a carbon number of 4 to 8 and, for example, includes cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl and cyclodecyl. These may be further condensed with “aryl” described later or “heterocyclic group” described later at an arbitrary position.
As the “cycloalkyl” in R1 and R2, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl are preferable.
A cycloalkyl part of the “cycloalkyl lower alkyl” and the “cycloalkylcarbonyl” is the same as the aforementioned “cycloalkyl”.
As the “cycloalkyl lower alkyl” in R5, cyclopropylmethyl is preferable.”
Examples of the substituent of the “optionally substituted cycloalkyl”include on or more substituents selected from the aforementioned Substituent group α. The substituent can replace at an arbitrary position, and may replace at a carbon atom having a bond of cycloalkyl.
The “cycloalkenyl” includes cycloalkenyl having one or more double bonds at an arbitrary position in a ring of the aforementioned cycloalkyl, and examples include cyclopropenyl, cyclobutenyl, cyclopentenyl, cyclohexenyl, cycloheptyl, cyclooctynyl and cyclohexadienyl.
As the “cycloalkenyl” in R1 or R2, cyclopropenyl, cyclobutenyl, cyclopentenyl, and cyclohexenyl are preferable.
A cycloalkenyl part of the “cycloalkenylcarbonyl” is the same as the aforementioned “cycloalkenyl”.
The substituent of the “optionally substituted cycloalkenyl” is the same as that of the aforementioned “optionally substituted cycloalkyl”.
The “aryl” includes phenyl, naphthyl, anthryl and phenanthryl, and phenyl is particularly preferable.
An aryl part of the “aryloxy”, the “arylthio”, the “aryl lower alkyl”, the “lower alkyldiarylsilyl”, the “triaryl lower alkylsilyl”, the “aryl lower alkyloxy lower alkyl”, the “arylsulfonyl”, the “arylsofamoyl”, the “arylamino”, the “arylcarbamoyl”, and the “arylsulfonylcarbamoyl” is the same as the aforementioned “aryl”.
Examples of the substituent of the “optionally substituted aryl”, the “optionally substituted phenyl”, and the “optionally substituted arylsulfonyl”include the Substituent group α, phenyl substituted with one or more groups selected from Substituent group α, phenoxy substituted with one or more groups selected from Substituent group α, and lower alkylenedioxy.
The “heterocyclic group” includes a heterocyclic group having one or more heteroatoms arbitrarily selected from O, S and N in a ring, and specifically includes a 5- to 6-membered heteroaryl such as pyrrolyl, imidazolyl, pyrazolyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazolyl, triazinyl, tetrazolyl, isoxazolyl, oxazolyl, oxadiazolyl, isothiazolyl, thiazolyl, thiadiazolyl, furyl and thienyl; a bicyclic condensed heterocyclic group such as indolyl, isoindolyl, indazolyl, indolidinyl, indolinyl, isoindolinyl, quinolyl, isoquinolyl, cinnolinyl, phthalazinyl, quinazolinyl, naphthridinyl, quinoxalinyl, purinyl, pteridinyl, benzopyranyl, benzimidazolyl, benzisoxazolyl, benzoxazolyl, benzoxadiazolyl, benzoisothiazolyl, benzothiazolyl, benzothiadiazolyl, benzofuryl, isobenzofuryl, benzothienyl, benzotriazolyl, imidazopyridyl, triazolopyridyl, imidazothiazolyl, pyrazinopyridazinyl, quinazolinyl, quinolyl, isoquinolyl, naphthyridinyl, dihydropyridyl, tetrahydroquinolyl, and tetrahydrobenzothienyl; a tricyclic condensed heterocyclic group such as carbazolyl, acridinyl, xanthenyl, phenothiazinyl, phenoxathiinyl, phenoxazinyl, and dibenzofuryl; a non-aromatic heterocyclic group such as dioxanyl, thiiranyl, thioranyl, thietanyl, oxilanyl, oxetanyl, oxathioranyl, azetidinyl, thianyl, pyrrolidinyl, pyrrolinyl, imidazolidinyl, imidazolinyl, pyrazolidinyl, pyrazolinyl, piperidyl, piperazinyl, morpholinyl, morpholino, thiomorpholinyl, thiomorpholino, dihydropyridyl, dihydrofuryl, tetrahydrofuryl, tetrahydropyranyl, tetrahydrothiazolyl, and tetrahydroisothiazolyl. Preferable is a 5- to 6-membered heteroaryl or a non-aromatic heterocyclic group.
As the “heterocyclic group” in R1 and R2, pyrazolyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, isoxazolyl, thiazolyl, thiadiazolyl, furyl, thienyl, indolyl, indazolyl, quinolyl, isoquinolyl, benzoxazolyl, benzothiazolyl, oxetanyl, tetrahydrofuryl, and tetrahydropyranyl are preferable. Pyridyl, pyridazinyl, pyrimidinyl, and pyrazinyl are more preferable. Pyridyl and pyrimidinyl are particularly preferable.
As the heterocyclic group of the “optionally substituted lower alkyl” in R1 and R2, isoxazolyl, oxazolyl, and oxadiazolyl are preferable. Oxadiazolyl is particularly preferable.
A heterocyclic part of the “heterocyclic oxy” and the “heterocyclic lower alkyl” is the same as the aforementioned “heterocyclic group”.
Examples of the substituent of the “optionally substituted heterocyclic group” include one or more groups selected from the group consisting of the Substituent group α and oxo. The substituent can replace at an arbitrary position, or may replace at a carbon atom or a nitrogen atom having a bond of the heterocyclic group.
The “acyl” includes straight or branched chain-like aliphatic acyl of a carbon number of 1 to 10, preferably a carbon number of 1 to 6, further preferably a carbon number of 1 to 4, cyclic aliphatic acyl of a carbon number of 4 to 9, preferably a carbon number of 4 to 7, aroyl and heterocyclic carbonyl. Herein, the “chain-like aliphatic” includes the aforementioned “lower alkyl”, the aforementioned “lower alkenyl”, and the aforementioned “lower alkynyl”. The “cyclic aliphatic” includes the aforementioned “cycloalkyl” and the aforementioned “cycloalkenyl”. A heterocyclic part of the heterocyclic carbonyl is the same as the aforementioned “heterocyclic group”. Examples of the acyl include formyl, acetyl, propionyl, butyryl, isobutyryl, valeryl, pivaloyl, hexanoyl, acryloyl, propioloyl, methacryloyl, crotonoyl, cyclopropylcarbonyl, cyclohexylcarbonyl, cyclooctylcarbonyl, benzoyl, pyridine carbonyl, piperidinecarbonyl, piperazinecarbonyl, morpholinocarbonyl, and the like.
An acyl part of the “acylaxy”, the “acylamino”, the “acylamino lower alkyl” and the “acyloxy lower alkyl” is the same as the aforementioned “acyl”.
The substituent of the “optionally substituted acyl” or the “optionally substituted” is the same as the substituent of the aforementioned “optionally substituted lower alkyl” when the “acyl” is chain-like aliphatic acyl, and includes one or more groups selected from the Substituent group a when the “acyl” is cyclic aliphatic acyl, aroyl or heterocyclic carbonyl.
The “optionally substituted heterocycle” formed when R1 and R2 are taken together with the nitrogen atom to which they are attached, includes a 5-membered or 6-membered heterocycle containing the nitrogen atom to which R1 and R2 are attached and, further, optionally containing one or more heteroatoms selected from N, S and O. For example, the case where
Figure USRE046365-20170411-C00005
is a saturated heterocycle group such as
Figure USRE046365-20170411-C00006
, or an unsaturated heterocycle group such as
Figure USRE046365-20170411-C00007
  • wherein R6, R7 and R8 are each independently hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, lower alkylthio, acyl, acyloxy, amino, lower alkylamino, acylamino, lower alkoxycarbonylamino, carboxy or lower alkoxycarbonyl,
  • is included and the preferable is a saturated heterocycle group such as morpholine ring, pyrrolidine ring, piperidine ring, piperazine ring, and the like optionally substituted with hydrogen, halogen, hydroxy or lower alkyl.
The substituent of the “optionally substituted heterocycle, which is formed when R1 and R2 are taken together with the nitrogen atom to which they are attached” is the same as the substituent of the “optionally substituted heterocyclic group”.
Figure USRE046365-20170411-C00008
includes, for example, the following:
Figure USRE046365-20170411-C00009
Figure USRE046365-20170411-C00010
Figure USRE046365-20170411-C00011
Figure USRE046365-20170411-C00012
  • wherein Ra is as defined above, and R is hydrogen or a group selected from Substituent group α.
Herein, the “solvate” includes, for example, a solvate with an organic solvent, a hydrate and the like. When a hydrate is formed, any number of water molecules may be coordinated.
The compound (I) includes a pharmaceutically acceptable salt. Examples include salts with alkali metals (lithium, sodium or potassium), alkaline earth metals (magnesium or calcium), ammonium, organic bases or amino acids, and salts with inorganic acids (hydrochloric acid, sulfuric acid, nitric acid, hydrobromic acid, phosphoric acid and hydroiodic acid), or organic acids (acetic acid, trifluoroacetic acid, citric acid, lactic acid, tartaric acid, oxalic acid, maleic acid, fumaric acid, mandelic acid, glutaric acid, malic acid, benzoic acid, phthalic acid, benzenesulfonic acid, p-toluene-sulfonic acid, methanesulfonic acid, or ethanesulfonic acid). Particularly, hydrochloric acid, phosphoric acid, tartaric acid, or methanesulfonic acid is preferable. These salts can be formed by a conventional method.
In addition, the compound (I) is not limited to a specific isomer, but includes all possible isomers and racemates. For example, when R3 of the compound (I) is hydroxy, the compound (I) includes other tautomer, that is, the following compound (I′).
Figure USRE046365-20170411-C00013
The present compound (I) can be produced by the following process.
Figure USRE046365-20170411-C00014
  • wherein RA is an ester residue, RB is hydrogen or hydroxy protecting group, and other symbols are as defined above.
Herein, the ester residue includes lower alkyl such as methyl, ethyl and the like, aryl lower alkyl such as benzyl, phenethyl and the like, acyloxy lower alkyl such as acetyloxymethyl and the like, etc.
The hydroxy protecting group is not limited to, but includes lower alkyl (methyl, tert-butyl etc.), aryl lower alkyl (triphenylmethyl, benzyl etc.), tri lower alkylsilyl(trimethylsilyl, tert-butyldimethylsilyl, triethylsilyl, triisopropylsilyl etc.), lower alkyldiarylsilyl(tert-butyldiphenylsilyl etc.), tri-aryl lower alkylsilyl(tribenzylsilyl etc.), lower alkoxy lower alkyl (methoxymethyl, 1-ethoxyethyl, 1-methyl-1-methoxy-ethyl etc.), lower alkoxy lower alkoxy lower alkyl(methoxy-ethoxymethyl etc.), lower alkylthio lower alkyl(methylthiomethyl etc.), optionally substituted tetrahydropyranyl (tetrahydropyran-2-yl, 4-methoxytetrahydropyran-4-yl etc.), tetrahydrothiopyranyl(tetrahydrothiopyran-2-yl etc.), tetrahydrofuranyl (tetrahydrofuran-2-yl etc.), tetrahydrothiofuranyl(tetrahydrothiofuran-2-yl etc.), aryl lower alkyloxy lower alkyl(benzyloxymethyl etc.), lower alkylsulfonyl (methanesulfonyl, ethanesulfonyl etc.), acyl(acetyl etc.) and arylsulfonyl(p-toluenesulfonyl etc.).
(First Step)
First, the known compound or compound (IV) derived therefrom is deprotected by a conventional method.
For example, when a protecting group is benzyl, the compound is dissolved or suspended in a suitable solvent (ethyl acetate, methanol, ethanol, tetrahydrofuran, dioxane, dimethylformamide, acetic acid, dilute hydrochloric acid, or a mixture thereof), and a hydrogenation reaction using a palladium catalyst (palladium hydroxide, palladium-carbon, palladium-barium sulfate, palladium-aluminum oxide, palladium black etc.) affords compound (III). A reaction may be performed at about 0° C. to about 100° C., preferably about 20° C. to about 50° C. for about 15 minutes to about 24 hours, preferably about 1 hour to about 5 hours.
(Second Step)
Then, the resulting compound (III) is directly amidated to obtain compound (Ia).
For example, compound (III) and compound (II) may be reacted by heating in a suitable solvent (methanol, ethanol, tetrahydrofuran, dimethylformamide, diethyl ether, dichloromethane, dichloroethane, toluene, xylene, chlorobenzene, orthodichlorobenzene, 2-methoxyethanol or diethylene glycol dimethyl ether or a mixture thereof) or without a solvent at about 0° C. to about 250° C., preferably about 80° C. to about 200° C. for about 30 minutes to about 24 hours, preferably about 1 to 12 hours in the presence or the absence of an amine compound (ammonia, dimethylamine, triethylamine, pyridine, dimethylaniline, dimethylaminopyridine, lutidine etc.).
In order to effectively carry a reaction forward, the reaction may be performed by microwave irradiation. A reaction temperature, and an irradiation time are not particularly limited, but are about 100° C. to about 200° C. and about 5 minutes to about 5 hours, preferably about 10 minutes to about 1 hour. It is preferable to use, as a solvent, a polar solvent such as methanol, ethanol, 1-propanol, ethylene glycol, glycerin, 2-methoxyethanol, 2-ethoxyethanol, N,N-dimethylformamide, diethylene glycol dimethyl ether and the like.
When R4 of objective compound (I) is lower alkyl, an objective compound can be obtained by the conventional etherization reaction at an arbitrary stage.
(B Process)
Figure USRE046365-20170411-C00015
  • wherein R3a is hydroxy, or optionally substituted lower alkoxy, and other symbols are as defined above.
    (First Step)
When R3 of objective compound (I) is optionally substituted lower alkoxy, first, the known compound (IV) is etherized by a conventional method.
For example, the compound is reacted with an alkylating agent or an alcohol having a R3a group corresponding to an objective compound in the presence of a base (sodium hydride, potassium hydride, sodium hydroxide, potassium hydroxide, calcium hydroxide, barium hydroxide, sodium carbonate, potassium carbonate, calcium carbonate, cesium carbonate, sodium methoxide, sodium ethoxide, potassium tert-butoxide, sodium bicarbonate or metal sodium), or under the condition of Mitsunobu reaction in a suitable solvent (N,N-dimethylformamide, dimethyl sulfoxide, toluene, benzene, xylene, a mixture thereof, or the like) cyclohexane, hexane, dichloromethane, 1,2-dichloroethane, tetrahydrofuran, dioxane, acetone, methyl ethyl ketone, acetonitrile, water or a mixture thereof) to obtain compound (VII). The reaction may be performed at −70 to 180° C., preferably about 0 to 150° C. for about 15 minutes to about 24 hours, preferably about 1 hour to about 5 hours.
(Second Step)
Then, compound (VII) is hydrolyzed to obtain compound (VI). The reaction may be performed under ice-cooling to at a reflux temperature of a solvent for about 15 minutes to about 24 hours, preferably, 1 hour to about 5 hours using an inorganic base (sodium hydroxide, lithium hydroxide or potassium hydroxide) in a suitable solvent (methanol, ethanol, tetrahydrofuran, dioxane, dimethylformamide or a mixture thereof).
(Third Step and Fourth Step)
Then, compound (VI) is amidated, and the resulting compound (V) is deprotected to obtain objective compound (Ib). These reactions may be performed by the same methods as those of the second step and the first step in A process, respectively. In an amidation step, the reaction may be performed, if necessary, in the presence of a condensing agent (N,N′-dicyclohexylcarbodiimide, N-dimethylaminopropyl-N′-ethylcarbodiimide, diethyl phosphoryl cyanide, diphenyl phosphoryl azide etc.).
In addition, when R4 of objective compound (I) is lower alkyl, an etherization reaction may be performed at an arbitrary stage as described above.
(C Process)
Figure USRE046365-20170411-C00016
  • wherein L is a leaving group, R3b is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted lower alkoxy, mercapto, optionally substituted lower alkylthio, optionally substituted amino, optionally substituted carbamoyl, optionally substituted aryl, or optionally substituted heterocyclic group, and other symbols are as defined above.
    (First Step)
When R3 of objective compound (I) is the R3b, a leaving group L (e.g. trifluoromethanesulfonyl, methanesulfonyl, phosphoric acid ester etc.) is introduced into the known compound (IV). For example, the compound is reacted with trifluoromethanesulfonic anhydride, trifluoromethanesulfonyl chloride, methanesulfonyl chloride, methanesulfonic anhydride, p-toluenesulfonyl chloride, N-phenyltrifluoromethanesulfonimide or various phosphoric acid esterifying reagents in the presence of a base (pyridine, triethylamine, ammonia, dimethylamine, dimethylaniline, dimethylaminopyridine, 2,6-lutidine or 2,6-di-tert-butylpyridine) using dichloromethane, chloroform, tetrahydrofuran, benzene, toluene, dimethylformamide, ethyl acetate or a mixture thereof as a solvent.
(Second Step)
The thus obtained compound (VIII) is subjected to the known substituent introducing reaction to obtain compound (IX).
(Third Step, Fourth Step and Fifth Step)
The compound (IX) is hydrolyzed, amidated, and deprotected by the same methods as those of the second step in B process, the second step in A process and the first step in A step, respectively, to obtain objective the compound (Ic).
In addition, when R4 of the objective compound (I) is lower alkyl, an etherization reaction may be performed at an arbitrary stage as described above.
(D Process)
compound (VIII) is obtained by the first step in C process, amidated according to the method of the fourth step in C process, and subjected to introduction of a substituent R3b, deprotection, and a hydrolysis reaction according to the methods of the second step, third step and fifth step in C process, respectively, thereby, objective compound (I) may be also obtained.
All of thus obtained present compounds have the opioid receptor antagonistic activity, and are useful as a drug, and among compounds represented by the formula (I), the following compounds are particularly preferable.
  • a) a compound in which R1 is hydrogen or lower alkyl,
  • b) a compound in which R1 is hydrogen or C1-C3 alkyl,
  • c) a compound in which R2 is:
  • (c-i) lower alkyl optionally substituted with one or more groups selected from Substituent group β (herein, Substituent group β is cycloalkyl optionally substituted with hydroxy, halogen, hydroxy, lower alkoxy, halogeno lower alkoxy, lower alkylthio, amino, lower alkylamino, carboxy, lower alkoxycarbonyl, cyano, lower alkylsulfonyl, aryl, aryloxy and lower alkylenedioxy),
  • (c-ii) phenyl optionally substituted with one or more groups selected from group consisting of Substituent group, lower alkyl and halogeno lower alkyl,
  • (c-iii) aryl lower alkyl optionally substituted with one or more groups selected from Substituent group β,
  • (c-iv) cycloalkyl optionally substituted with one or more groups selected from Substituent group β,
  • (c-v) heterocyclic group optionally substituted with one or more groups selected from Substituent group β, or
  • (c-vi) heterocyclic lower alkyl optionally substituted with one or more groups selected from Substituent group β,
  • d) a compound in which R2 is:
  • (d-i) lower alkyl optionally substituted with hydroxy, cycloalkyl optionally substituted with hydroxy, lower alkoxy, lower alkylthio, lower alkylamino or aryloxy,
  • (d-ii) phenyl optionally substituted with halogen, lower alkyl, halogeno lower alkyl, lower alkoxy, halogeno lower alkoxy, lower alkylthio, amino, lower alkylamino, cyano, lower alkylsulfonyl or lower alkylenedioxy,
  • (d-iii) aryl lower alkyl optionally substituted with lower alkoxy or lower alkylthio,
  • (d-iv) cycloalkyl optionally substituted with lower alkyl, carboxy or lower alkoxycarbonyl,
  • (d-v) a heterocyclic group optionally substituted with lower alkyl, lower alkoxy or phenyl, or
  • (d-vi) heterocyclic lower alkyl optionally substituted with lower alkyl or aryl,
  • e) a compound in which R1 and R2 are taken together with a N atom to which they bind to form a 5-membered or 6-membered saturated heterocycle,
  • f) a compound in which R3 is hydroxy or lower alkoxy,
  • g) a compound in which R3 is hydroxy,
  • h) a compound in which R3 is amino optionally substituted with one or more groups selected from Substituent group α,
  • i) a compound in which R3 is halogen, lower alkyl, or amino substituted with arylsulfonyl optionally substituted with lower alkoxy,
  • j) a compound in which R4 is hydrogen or methoxy,
  • k) a compound in which R5 is cycloalkyl lower alkyl or lower alkenyl,
  • l) a compound in which R5 is cyclopropylmethyl or allyl,
  • m) a compound in which R5 is cyclopropylmethyl,
  • n) a compound in which R1 is hydrogen or lower alkyl, R2 is the (d-i), R3 is hydroxy or lower alkoxy, R4 is hydrogen, and R5 is cycloalkyl lower alkyl or lower alkenyl,
  • o) a compound in which R1 is hydrogen or lower alkyl, R2 is the (d-i), R3 is hydroxy or lower alkoxy, R4 is hydrogen, and R5 is cyclopropylmethyl,
  • p) a compound in which R1 is hydrogen or lower alkyl, R2 is the (d-i), R3 is halogen, lower alkyl, or amino substituted with arylsulfonyl optionally substituted with lower alkoxy, R4 is hydrogen, and R5 is cycloalkyl lower alkyl or lower alkenyl,
  • q) a compound in which R1 is hydrogen or lower alkyl, R2 is the (d-i), R3 is halogen, lower alkyl, or amino substituted with arylsulfonyl optionally substituted with lower alkoxy, R4 is hydrogen, and R5 is cyclopropylmethyl,
  • r) a compound in which R1 is hydrogen or lower alkyl, R2 is the (d-ii), R3 is hydroxy or lower alkoxy, R4 is hydrogen, and R5 is cycloalkyl lower alkyl or lower alkenyl,
  • s) a compound in which R1 is hydrogen or lower alkyl, R2 is the (d-ii), R3 is hydroxy or lower alkoxy, R4 is hydrogen, and R5 is cyclopropylmethyl,
  • t) a compound in which R1 is hydrogen or lower alkyl, R2 is the (d-iii), R3 is hydroxy or lower alkoxy, R4 is hydrogen, and R5 is cycloalkyl lower alkyl or lower alkenyl,
  • u) a compound in which R1 is hydrogen or lower alkyl, R2 is the (d-iii), R3 is hydroxy or lower alkoxy, R4 is hydrogen, and R5 is cyclopropylmethyl,
  • v) a compound in which R1 is hydrogen or lower alkyl, R2 is the (d-iv), R3 is hydroxy or lower alkoxy, R4 is hydrogen, and R5 is cycloalkyl lower alkyl or lower alkenyl,
  • w) a compound in which R1 is hydrogen or lower alkyl, R2 is the (d-iv), R3 is hydroxy or lower alkoxy, R4 is hydrogen, and R5 is cyclopropylmethyl,
  • x) a compound in which R1 is hydrogen or lower alkyl, R2 is the (d-v), R3 is hydroxy or lower alkoxy, R4 is hydrogen, and R5 is cycloalkyl lower alkyl or lower alkenyl,
  • y) a compound in which R1 is hydrogen or lower alkyl, R2 is the (d-v), R3 is hydroxy or lower alkoxy, R4 is hydrogen, and R5 is cyclopropylmethyl,
  • z) a compound in which R1 is hydrogen or lower alkyl, R2 is the (d-yl), R3 is hydroxy or lower alkoxy, R4 is hydrogen, and R5 is cycloalkyl lower alkyl or lower alkenyl,
  • aa) a compound in which R1 is hydrogen or lower alkyl, R2 is the (d-yl), R3 is hydroxy or lower alkoxy, R4 is hydrogen, and R5 is cyclopropylmethyl,
  • ab) a compound in which R1 and R2 are taken together with a N atom to which they bind to form a 5-membered or 6-membered saturated heterocycle, R3 is hydroxy or lower alkoxy, R4 is hydrogen, and R5 is cycloalkyl lower alkyl group or lower alkenyl,
  • ac) a compound in which R1 and R2 are taken together with a N atom to which they bind to form a 5-membered or 6-membered saturated heterocycle, R3 is hydroxy or lower alkoxy, R4 is hydrogen, and R5 is cyclopropylmethyl,
  • or a pharmaceutically acceptable salt or a solvate thereof.
In a compound represented by the formula (I), a compound in which R4 is hydrogen, R5 is cyclopropylmethyl, and a combination of NR1R2 and R3 (NR1R2, R3) is the following.
TABLE 1
Figure USRE046365-20170411-C00017
NR1R2 CR9R10
AA —NHiPr —
AB
Figure USRE046365-20170411-C00018
 		—
AC
Figure USRE046365-20170411-C00019
 		—
AD
Figure USRE046365-20170411-C00020
 		—
AE
Figure USRE046365-20170411-C00021
 		—
AF
Figure USRE046365-20170411-C00022
 		—
AG —NHCR9R10CONH2 Ra
AH —NHCR9R10CONH2 Rb
AI —NHCR9R10CONH2 Rc
AJ —NHCR9R10CONH2 Rd
AK —NHCR9R10CONH2 Re
AL —NHCR9R10CONH2 Rf
AM —NHCR9R10CONH2 Rg
AN —NHCR9R10CONH2 Rh
AO —NHCR9R10CONH2 Ri
AP —NHCR9R10CONH2 Rj
AQ —NHCR9R10CONH2 Rk
AR —NHCR9R10CONH2 Rl
AS —NHCR9R10CONH2 Rm
AT —NHCR9R10CONH2 Rn
AU —NHCR9R10CONH2 Ro
AV —NHCR9R10CONH2 Rp
AW —NHCR9R10CONH2 Rq
AX —NHCR9R10CONH2 Rr
AY —NHCR9R10CONH2 Rs
AZ —NHCR9R10CONH2 Rt
BA —NHCR9R10CONMe2 Ra
BB —NHCR9R10CONMe2 Rb
BC —NHCR9R10CONMe2 Rc
BD —NHCR9R10CONMe2 Rd
BE —NHCR9R10CONMe2 Re
BF —NHCR9R10CONMe2 Rf
BG —NHCR9R10CONMe2 Rg
BH —NHCR9R10CONMe2 Rh
BI —NHCR9R10CONMe2 Ri
BJ —NHCR9R10CONMe2 Rj
BK —NHCR9R10CONMe2 Rk
BL —NHCR9R10CONMe2 Rl
BM —NHCR9R10CONMe2 Rm
BN —NHCR9R10CONMe2 Rn
BO —NHCR9R10CONMe2 Ro
BP —NHCR9R10CONMe2 Rp
BQ —NHCR9R10CONMe2 Rq
BR —NHCR9R10CONMe2 Rr
BS —NHCR9R10CONMe2 Rs
BT —NHCR9R10CONMe2 Rt
BU —NHCR9R10COOH Ra
BV —NHCR9R10COOH Rb
BW —NHCR9R10COOH Rc
BX —NHCR9R10COOH Rd
BY —NHCR9R10COOH Re
BZ —NHCR9R10COOH Rf
CA —NHCR9R10COOH Rg
CB —NHCR9R10COOH Rh
CC —NHCR9R10COOH Ri
CD —NHCR9R10COOH Rj
CE —NHCR9R10COOH Rk
CF —NHCR9R10COOH Rl
CG —NHCR9R10COOH Rm
CH —NHCR9R10COOH Rn
CI —NHCR9R10COOH Ro
CJ —NHCR9R10COOH Rp
CK —NHCR9R10COOH Rq
CL —NHCR9R10COOH Rr
CM —NHCR9R10COOH Rs
CN —NHCR9R10COOH Rt
CO —NHCR9R10COOMe Ra
CP —NHCR9R10COOMe Rb
CQ —NHCR9R10COOMe Rc
CR —NHCR9R10COOMe Rd
TABLE 2
NR1R2 CR9R10
CS —NHCR9R10COOMe Re
CT —NHCR9R10COOMe Rf
CU —NHCR9R10COOMe Rg
CV —NHCR9R10COOMe Rh
CW —NHCR9R10COOMe Ri
CX —NHCR9R10COOMe Rj
CY —NHCR9R10COOMe Rk
CZ —NHCR9R10COOMe Rl
DA —NHCR9R10COOMe Rm
DB —NHCR9R10COOMe Rn
DC —NHCR9R10COOMe Ro
DD —NHCR9R10COOMe Rp
DE —NHCR9R10COOMe Rq
DF —NHCR9R10COOMe Rr
DG —NHCR9R10COOMe Rs
DH —NHCR9R10COOMe Rt
DI —NHCR9R10COOEt Ra
DJ —NHCR9R10COOEt Rb
DK —NHCR9R10COOEt Rc
DL —NHCR9R10COOEt Rd
DM —NHCR9R10COOEt Re
DN —NHCR9R10COOEt Rf
DO —NHCR9R10COOEt Rg
DP —NHCR9R10COOEt Rh
DQ —NHCR9R10COOEt Ri
DR —NHCR9R10COOEt Rj
DS —NHCR9R10COOEt Rk
DT —NHCR9R10COOEt Rl
DU —NHCR9R10COOEt Rm
DV —NHCR9R10COOEt Rn
DW —NHCR9R10COOEt Ro
DX —NHCR9R10COOEt Rp
DY —NHCR9R10COOEt Rq
DZ —NHCR9R10COOEt Rr
EA —NHCR9R10COOEt Rs
EB —NHCR9R10COOEt Rt
EC —NHCR9R10COOiPr Ra
ED —NHCR9R10COOiPr Rb
EE —NHCR9R10COOiPr Rc
EF —NHCR9R10COOiPr Rd
EG —NHCR9R10COOiPr Re
EH —NHCR9R10COOiPr Rf
EI —NHCR9R10COOiPr Rg
EJ —NHCR9R10COOiPr Rh
EK —NHCR9R10COOiPr Ri
EL —NHCR9R10COOiPr Rj
EM —NHCR9R10COOiPr Rk
EN —NHCR9R10COOiPr Rl
EO —NHCR9R10COOiPr Rm
EP —NHCR9R10COOiPr Rn
EQ —NHCR9R10COOiPr Ro
ER —NHCR9R10COOiPr Rp
ES —NHCR9R10COOiPr Rq
ET —NHCR9R10COOiPr Rr
EU —NHCR9R10COOiPr Rs
EV —NHCR9R10COOiPr Rt
EW —NHCR9R10CONHMe Ra
EX —NHCR9R10CONHMe Rb
EY —NHCR9R10CONHMe Rc
EZ —NHCR9R10CONHMe Rd
FA —NHCR9R10CONHMe Re
FB —NHCR9R10CONHMe Rf
FC —NHCR9R10CONHMe Rg
FD —NHCR9R10CONHMe Rh
FE —NHCR9R10CONHMe Ri
FF —NHCR9R10CONHMe Rj
FG —NHCR9R10CONHMe Rk
FH —NHCR9R10CONHMe Rl
FI —NHCR9R10CONHMe Rm
FJ —NHCR9R10CONHMe Rn
FK —NHCR9R10CONHMe Ro
FL —NHCR9R10CONHMe Rp
FM —NHCR9R10CONHMe Rq
FN —NHCR9R10CONHMe Rr
FO —NHCR9R10CONHMe Rs
FP —NHCR9R10CONHMe Rt
FQ —NHCR9R10CONHiPr Ra
FR —NHCR9R10CONHiPr Rb
FS —NHCR9R10CONHiPr Rc
FT —NHCR9R10CONHiPr Rd
FU —NHCR9R10CONHiPr Re
FV —NHCR9R10CONHiPr Rf
FW —NHCR9R10CONHiPr Rg
FX —NHCR9R10CONHiPr Rh
FY —NHCR9R10CONHiPr Ri
FZ —NHCR9R10CONHiPr Rj
GA —NHCR9R10CONHiPr Rk
GB —NHCR9R10CONHiPr Rl
GC —NHCR9R10CONHiPr Rm
GD —NHCR9R10CONHiPr Rn
GE —NHCR9R10CONHiPr Ro
GF —NHCR9R10CONHiPr Rp
GG —NHCR9R10CONHiPr Rq
GH —NHCR9R10CONHiPr Rr
GI —NHCR9R10CONHiPr Rs
GJ —NHCR9R10CONHiPr Rt
GK —NHCR9R10CONHPh Ra
GL —NHCR9R10CONHPh Rb
GM —NHCR9R10CONHPh Rc
GN —NHCR9R10CONHPh Rd
GO —NHCR9R10CONHPh Re
GP —NHCR9R10CONHPh Rf
GQ —NHCR9R10CONHPh Rg
GR —NHCR9R10CONHPh Rh
GS —NHCR9R10CONHPh Ri
GT —NHCR9R10CONHPh Rj
GU —NHCR9R10CONHPh Rk
GV —NHCR9R10CONHPh Rl
GW —NHCR9R10CONHPh Rm
GX —NHCR9R10CONHPh Rn
GY —NHCR9R10CONHPh Ro
GZ —NHCR9R10CONHPh Rp
HA —NHCR9R10CONHPh Rq
HB —NHCR9R10CONHPh Rr
HC —NHCR9R10CONHPh Rs
HD —NHCR9R10CONHPh Rt
TABLE 3
NR1R2 CR9R10
HE —NHCR9R10CONHCN Ra
HF —NHCR9R10CONHCN Rb
HG —NHCR9R10CONHCN Rc
HH —NHCR9R10CONHCN Rd
HI —NHCR9R10CONHCN Re
HJ —NHCR9R10CONHCN Rf
HK —NHCR9R10CONHCN Rg
HL —NHCR9R10CONHCN Rh
HM —NHCR9R10CONHCN Ri
HN —NHCR9R10CONHCN Rj
HO —NHCR9R10CONHCN Rk
HP —NHCR9R10CONHCN Rl
HQ —NHCR9R10CONHCN Rm
HR —NHCR9R10CONHCN Rn
HS —NHCR9R10CONHCN Ro
HT —NHCR9R10CONHCN Rp
HU —NHCR9R10CONHCN Rq
HV —NHCR9R10CONHCN Rr
HW —NHCR9R10CONHCN Rs
HX —NHCR9R10CONHCN Rt
HY —NHCR9R10CONHSO2Me Ra
HZ —NHCR9R10CONHSO2Me Rb
IA —NHCR9R10CONHSO2Me Rc
IB —NHCR9R10CONHSO2Me Rd
IC —NHCR9R10CONHSO2Me Re
ID —NHCR9R10CONHSO2Me Rf
IE —NHCR9R10CONHSO2Me Rg
IF —NHCR9R10CONHSO2Me Rh
IG —NHCR9R10CONHSO2Me Ri
IH —NHCR9R10CONHSO2Me Rj
II —NHCR9R10CONHSO2Me Rk
IJ —NHCR9R10CONHSO2Me Rl
IK —NHCR9R10CONHSO2Me Rm
IL —NHCR9R10CONHSO2Me Rn
IM —NHCR9R10CONHSO2Me Ro
IN —NHCR9R10CONHSO2Me Rp
IO —NHCR9R10CONHSO2Me Rq
IP —NHCR9R10CONHSO2Me Rr
IQ —NHCR9R10CONHSO2Me Rs
IR —NHCR9R10CONHSO2Me Rt
IS —NHCR9R10CH2OMe Ra
IT —NHCR9R10CH2OMe Rb
IU —NHCR9R10CH2OMe Rc
IV —NHCR9R10CH2OMe Rd
IW —NHCR9R10CH2OMe Re
IX —NHCR9R10CH2OMe Rf
IY —NHCR9R10CH2OMe Rg
IZ —NHCR9R10CH2OMe Rh
JA —NHCR9R10CH2OMe Ri
JB —NHCR9R10CH2OMe Rj
JC —NHCR9R10CH2OMe Rk
JD —NHCR9R10CH2OMe Rl
JE —NHCR9R10CH2OMe Rin
JF —NHCR9R10CH2OMe Rn
JG —NHCR9R10CH2OMe Ro
JH —NHCR9R10CH2OMe Rp
JI —NHCR9R10CH2OMe Rq
JJ —NHCR9R10CH2OMe Rr
JK —NHCR9R10CH2OMe Rs
JL —NHCR9R10CH2OMe Rt
JM
Figure USRE046365-20170411-C00023
 		Ra
JN
Figure USRE046365-20170411-C00024
 		Rb
JO
Figure USRE046365-20170411-C00025
 		Rc
JP
Figure USRE046365-20170411-C00026
 		Rd
JQ
Figure USRE046365-20170411-C00027
 		Re
JR
Figure USRE046365-20170411-C00028
 		Rf
JS
Figure USRE046365-20170411-C00029
 		Rg
JT
Figure USRE046365-20170411-C00030
 		Rh
TABLE 4
NR1R2 CR9R10
JU
Figure USRE046365-20170411-C00031
 		Ri
JV
Figure USRE046365-20170411-C00032
 		Rj
JW
Figure USRE046365-20170411-C00033
 		Rk
JX
Figure USRE046365-20170411-C00034
 		Rl
JY
Figure USRE046365-20170411-C00035
 		Rm
JZ
Figure USRE046365-20170411-C00036
 		Rn
KA
Figure USRE046365-20170411-C00037
 		Ro
KB
Figure USRE046365-20170411-C00038
 		Rp
KC
Figure USRE046365-20170411-C00039
 		Rq
KD
Figure USRE046365-20170411-C00040
 		Rr
KE
Figure USRE046365-20170411-C00041
 		Rs
KF
Figure USRE046365-20170411-C00042
 		Rt
KG
Figure USRE046365-20170411-C00043
 		Ra
KH
Figure USRE046365-20170411-C00044
 		Rb
KI
Figure USRE046365-20170411-C00045
 		Rc
KJ
Figure USRE046365-20170411-C00046
 		Rd
KK
Figure USRE046365-20170411-C00047
 		Re
KL
Figure USRE046365-20170411-C00048
 		Rf
KM
Figure USRE046365-20170411-C00049
 		Rg
KN
Figure USRE046365-20170411-C00050
 		Rh
KO
Figure USRE046365-20170411-C00051
 		Ri
KP
Figure USRE046365-20170411-C00052
 		Rj
KQ
Figure USRE046365-20170411-C00053
 		Rk
KR
Figure USRE046365-20170411-C00054
 		Rl
KS
Figure USRE046365-20170411-C00055
 		Rm
KT
Figure USRE046365-20170411-C00056
 		Rn
KU
Figure USRE046365-20170411-C00057
 		Ro
KV
Figure USRE046365-20170411-C00058
 		Rp
KW
Figure USRE046365-20170411-C00059
 		Rq
KX
Figure USRE046365-20170411-C00060
 		Rr
KY
Figure USRE046365-20170411-C00061
 		Rs
KZ
Figure USRE046365-20170411-C00062
 		Rt
TABLE 5
NR1R2 CR9R10
LA
Figure USRE046365-20170411-C00063
 		Ra
LB
Figure USRE046365-20170411-C00064
 		Rb
LC
Figure USRE046365-20170411-C00065
 		Rc
LD
Figure USRE046365-20170411-C00066
 		Rd
LE
Figure USRE046365-20170411-C00067
 		Re
LF
Figure USRE046365-20170411-C00068
 		Rf
LG
Figure USRE046365-20170411-C00069
 		Rg
LH
Figure USRE046365-20170411-C00070
 		Rh
LI
Figure USRE046365-20170411-C00071
 		Ri
LJ
Figure USRE046365-20170411-C00072
 		Rj
LK
Figure USRE046365-20170411-C00073
 		Rh
LL
Figure USRE046365-20170411-C00074
 		Rl
LM
Figure USRE046365-20170411-C00075
 		Rm
LN
Figure USRE046365-20170411-C00076
 		Rn
LO
Figure USRE046365-20170411-C00077
 		Ro
LP
Figure USRE046365-20170411-C00078
 		Rp0
LQ
Figure USRE046365-20170411-C00079
 		Rq
LR
Figure USRE046365-20170411-C00080
 		Rr
LS
Figure USRE046365-20170411-C00081
 		Rs
LT
Figure USRE046365-20170411-C00082
 		Rt
LU
Figure USRE046365-20170411-C00083
 		Ra
LV
Figure USRE046365-20170411-C00084
 		Rb
LW
Figure USRE046365-20170411-C00085
 		Rc
LX
Figure USRE046365-20170411-C00086
 		Rd
LY
Figure USRE046365-20170411-C00087
 		Re
LZ
Figure USRE046365-20170411-C00088
 		Rf
MA
Figure USRE046365-20170411-C00089
 		Rg
MB
Figure USRE046365-20170411-C00090
 		Rh
MC
Figure USRE046365-20170411-C00091
 		Ri
MD
Figure USRE046365-20170411-C00092
 		Rj
ME
Figure USRE046365-20170411-C00093
 		Rk
MF
Figure USRE046365-20170411-C00094
 		Rl
TABLE 6
NR1R2 CR9R10
MG
Figure USRE046365-20170411-C00095
 		Rm
MH
Figure USRE046365-20170411-C00096
 		Rn
MI
Figure USRE046365-20170411-C00097
 		Ro
MJ
Figure USRE046365-20170411-C00098
 		Rp
MK
Figure USRE046365-20170411-C00099
 		Rq
ML
Figure USRE046365-20170411-C00100
 		Rr
MM
Figure USRE046365-20170411-C00101
 		Rs
MN
Figure USRE046365-20170411-C00102
 		Rt
  • In the above Tables, CR9CR10 is represented by the following symbol.
TABLE 7
CR9R10
Ra
Figure USRE046365-20170411-C00103
RB
Figure USRE046365-20170411-C00104
Rc
Figure USRE046365-20170411-C00105
Rd
Figure USRE046365-20170411-C00106
Re
Figure USRE046365-20170411-C00107
Rf
Figure USRE046365-20170411-C00108
Rg
Figure USRE046365-20170411-C00109
Rh
Figure USRE046365-20170411-C00110
Ri
Figure USRE046365-20170411-C00111
Rj
Figure USRE046365-20170411-C00112
Rk
Figure USRE046365-20170411-C00113
Rl
Figure USRE046365-20170411-C00114
Rm
Figure USRE046365-20170411-C00115
Rn
Figure USRE046365-20170411-C00116
Ro
Figure USRE046365-20170411-C00117
Rp
Figure USRE046365-20170411-C00118
Rq
Figure USRE046365-20170411-C00119
Rr
Figure USRE046365-20170411-C00120
Rs
Figure USRE046365-20170411-C00121
Rt
Figure USRE046365-20170411-C00122
TABLE 8
R3
VA H
VB Me
VC OH
VD OMe
VE CONH2
VF CONHiPr
VG NH2
VH NHAc
VI NHSO2Me
VJ Ph
VK
Figure USRE046365-20170411-C00123
VL
Figure USRE046365-20170411-C00124
VM
Figure USRE046365-20170411-C00125
VN
Figure USRE046365-20170411-C00126
VO
Figure USRE046365-20170411-C00127
VP
Figure USRE046365-20170411-C00128
VQ
Figure USRE046365-20170411-C00129
VR
Figure USRE046365-20170411-C00130
VS NHSO2Ph
VT NHCOPh
VU CONHMe
VV CONMe2
VW NHMe
VX NHiPr
VY NHPh
VZ
Figure USRE046365-20170411-C00131
WA
Figure USRE046365-20170411-C00132
WB
Figure USRE046365-20170411-C00133
WC
Figure USRE046365-20170411-C00134
  • (AA,VA), (AA,VB), (AA,VC), (AA,VD), (AA,VE), (AA, VF), (AA,VG), (AA,VH), (AA,VI), (AA,VJ), (AA,VK), (AA,VL), (AA,VM), (AA,VN), (AA,VO), (AA,VP), (AA, VQ), (AA,VR), (AA,VS), (AA,VT), (AA,VU), (AA,VV), (AA,VW), (AA,VX), (AA,VY), (AA,VZ), (AA,WA), (AA,WB), (AA,WC), (AB,VA), (AB,VB), (AB,VC), (AB, VD), (AB,VE), (AB,VF), (AB,VG), (AB,VH), (AB,VI), (AB,VJ), (AB,VK), (AB,VL), (AB,VM), (AB,VN), (AB, VO), (AB,VP), (AB,VQ), (AB,VR), (AB,VS), (AB,VT), (AB,VU), (AB,VV), (AB,VW), (AB,VX), (AB,VY), (AB, VZ), (AB,WA), (AB,WB), (AB,WC), (AC,VA), (AC,VB), (AC,VC), (AC,VD), (AC,VE), (AC,VF), (AC,VG), (AC, VH), (AC,VI), (AC,VJ), (AC,VK), (AC,VL), (AC,VM), (AC,VN), (AC,VO), (AC,VP), (AC,VQ), (AC,VR), (AC, VS), (AC,VT), (AC,VU), (AC,VV), (AC,VW), (AC,VX), (AC,VY), (AC,VZ), (AC,WA), (AC,WB), (AC,WC), (AD, VA), (AD,VB), (AD,VC), (AD,VD), (AD,VE), (AD,VF), (AD,VG), (AD,VH), (AD,VI), (AD,VJ), (AD,VK), (AD, VL), (AD,VM), (AD,VN), (AD,VO), (AD,VP), (AD,VQ), (AD,VR), (AD,VS), (AD,VT), (AD,VU), (AD,VW), (AD, VW), (AD,VX), (AD,VY), (AD,VZ), (AD,WA), (AD,WB), (AD,WC), (AE,VA), (AE,VB), (AE,VC), (AE, VD), (AE,VE), (AE,VF), (AE,VG), (AE,VH), (AE,VI), (AE,VJ), (AE,VK), (AE,VL), (AE,VM), (AE,VN), (AE, VO), (AE,VP), (AE,VQ), (AE,VR), (AE,VS), (AE,VT), (AE,VU), (AE,VV), (AE,VW), (AE,VX), (AE,VY), (AE, VZ), (AE,WA), (AE,WB), (AE,WC), (AF,VA), (AF,VB), (AF,VC), (AF,VD), (AF,VE), (AF,VF), (AF,VG), (AF,VH), (AF,VI), (AF,VJ), (AF,VK), (AF,VL), (AF,VM), (AF,VN), (AF,VO), (AF,VP), (AF,VQ), (AF,VR), (AF,VS), (AF,VT), (AF,VU), (AF,VV), (AF,VW), (AF, VX), (AF,VY), (AF,VZ), (AF,WA), (AF,WB), (AF,WC), (AG,VA), (AG,VB), (AG,VC), (AG,VD), (AG,VE), (AG, VF), (AG,VG), (AG,VH), (AG,VI), (AG,VJ), (AG,VK), (AG,VL), (AG,VM), (AG,VN), (AG,VO), (AG,VP), (AG, VQ), (AG,VR), (AG,VS), (AG,VT), (AG,VU), (AG,VV), (AG,VW), (AG, VX), (AG,VY), (AN,VZ), (AG,WA), (AG,WB), (AG,WC), (AH,VA), (AH,VB), (AH,VC), (AH,VD), (AH,VE), (AH,VF), (AH,VG), (AH,VH), (AH, VI), (AH,VJ), (AH,VK), (AH,VL), (AH,VM), (AH,VN), (AH,VO), (AH,VP), (AH,VQ), (AH,VR), (AH,VS), (AH, VT), (AH,VU), (AH,VV), (AH,VW), (AH,VX), (AH,VY), (AH,VZ), (AH,WA), (AH,WB), (AH,WC), (AI, VA), (AI,VB), (AI,VC), (AI,VD), (AI,VE), (AI,VF), (AI, VG), (AI,VH), (AI,VI), (AI,VJ), (AI,VK), (AI,VL), (AI, VM), (AI,VN), (AI,VO), (AI,VP), (AI,VQ), (AI,VR), (AI, VS), (AI,VT), (AI,VU), (AI,VV), (AI,VW), (AI,VX), (AI, VY), (AI,VZ), (AI,WA), (AI,WB), (AI,WC), (AJ,VA), (AJ,VB), (AJ,VC), (AJ,VD), (AJ,VE), (AJ,VF), (AJ,VG), (AJ,VH), (AJ,VI), (AJ,VJ), (AJ,VK), (AJ,VL), (AJ,VM), (AJ,VN), (AJ,VO), (AJ,VP), (AJ,VQ), (AJ,VR), (AJ,VS), (AJ,VT), (AJ,VU), (AJ,VV), (AJ,VW), (AJ,VX), (AJ,VY), (AJ,VZ), (AJ,WA), (AJ,WB), (AJ,WC), (AK, VA), (AK,VB), (AK,VC), (AK,VD), (AK,VE), (AK,VF), (AK,VG), (AK,VH), (AK,VI), (AK,VJ), (AK,VK), (AK, VL), (AK,VM), (AK,VN), (AK,VO), (AK,VP), (AK,VQ), (AK,VR), (AK,VS), (AK,VT), (AK,VU), (AK,VV), (AK, VW), (AK,VX), (AK,VY), (AK,VZ), (AK,WA), (AK,WB), (AK,WC), (AL,VA), (AL,VB), (AL,VC), (AL, VD), (AL,VE), (AL,VF), (AL,VG), (AL,VH), (AL,VI), (AL,VJ), (AL,VK), (AL,VL), (AL,VM), (AL,VN), (AL, VO), (AL,VP), (AL,VQ), (AL,VR), (AL,VS), (AL,VT), (AL,VU), (AL,VV), (AL,VW), (AL,VX), (AL,VY), (AL, VZ), (AL,WA), (AL,WB), (AL,WC), (AM,VA), (AM,VB), (AM,VC), (AM,VD), (AM,VE), (AM,VF), (AM,VG), (AM,VH), (AM,VI), (AM,VJ), (AM,VK), (AM,VL), (AM,VM), (AM,VN), (AM,VO), (AM,VP), (AM,VQ), (AM,VR), (AM,VS), (AM,VT), (AM,VU), (AM,VV), (AM,VW), (AM,VX), (AM,VY), (AM,VZ), (AM,WA), (AM,WB), (AM,WC), (AN,VA), (AN,VB), (AN,VC), (AN,VD), (AN,VE), (AN,VF), (AN,VG), (AN, VH), (AN,VI), (AN,VJ), (AN,VK), (AN,VL), (AN,VM), (AN,VN), (AN,VO), (AN,VP), (AN,VQ), (AN,VR), (AN, VS), (AN,VT), (AN,VU), (AN,VV), (AN,VW), (AN,VX), (AN,VY), (AN,VZ), (AN,WA), (AN,WB), (AN,WC), (AO,VA), (AO,VB), (AO,VC), (AO,VD), (AO,VE), (AO, VF), (AO,VG), (AO,VH), (AO,VI), (AO,VJ), (AO,VK), (AO,VL), (AO,VM), (AO,VN), (AO,VO), (AO,VP), (AO, VQ), (AO,VR), (AO,VS), (AO,VT), (AO,VU), (AO,VV), (AO,VW), (AO,VX), (AO,VY), (AO,VZ), (AO,WA), (AO, WB), (AO,WC), (AP,VA), (AP,VB), (AP,VC), (AP,VD), (AP,VE), (AP,VF), (AP,VG), (AP,VH), (AP,VI), (AP,VJ), (AP,VK), (AP,VL), (AP,VM), (AP,VN), (AP,VO), (AP,VP), (AP,VQ), (AP,VR), (AP,VS), (AP,VT), (AP,VU), (AP,VV), (AP,VW), (AP,VX), (AP,VY), (AP,VZ), (AP,WA), (AP,WB), (AP,WC), (AQ,VA), (AQ,VB), (AQ, VC), (AQ,VD), (AQ,VE), (AQ,VF), (AQ,VG), (AQ,VH), (AQ,VI), (AQ,VJ), (AQ,YK), (AQ,VL), (AQ,VM), (AQ, VN), (AQ,VO), (AQ,VP), (AQ,VQ), (AQ,VR), (AQ,VS), (AQ,VT), (AQ,VU), (AQ,VV), (AQ,VW), (AQ,VX), (AQ, VY), (AQ,VZ), (AQ,WA), (AQ,WB), (AA,WC), (AR,VA), (AR,VB), (AR,VC), (AR,VD), (AR,VE), (AR,VF), (AR, VG), (AR,VH), (AR,VI), (AR,VJ), (AR,VK), (AR,VL), (AR,VM), (AR,VN), (AR,VO), (AR,VP), (AR,VQ), (AR, VR), (AR,VS), (AR,VT), (AR,VU), (AR,VV), (AR,VW), (AR,VX), (AR,VY), (AR,VZ), (AR,WA), (AR,WB), (AR, WC), (AS,VA), (AS,VB), (AS,VC), (AS,VD), (AS,VE), (AS,VF), (AS,VG), (AS,VH), (AS,VI), (AS,VJ), (AS,VK), (AS,VL), (AS,VM), (AS,VN), (AS,VO), (AS, VP), (AS,VQ), (AS,VR), (AS,VS), (AS,VT), (AS,VU), (AS,VV), (AS,VW), (AS,VX), (AS,VY), (AS,VZ), (AS, WA), (AS,WB), (AS,WC), (AT,VA), (AT,VB), (AT,VC), (AT,VD), (AT,VE), (AT,VF), (AT,VG), (AT,VH), (AT,VI), (AT,VJ), (AT,VK), (AT,VL), (AT,VM), (AT,VN), (AT,VO), (AT,VP), (AT,VQ), (AT,VR), (AT,VS), (AT,VT), (AT,VU), (AT,VV), (AT,VW), (AT,VX), (AT,VY), (AT,VZ), (AT,WA), (AT,WB), (AT,WC), (AU,VA), (AU,VB), (AU, VC), (AU,VD), (AU,VE), (AU,VF), (AU,VG), (AU,VH), (AU,VI), (AU,VJ), (AU,VK), (AU,VL), (AU,VM), (AU, VN), (AU,VO), (AU,VP), (AU,VQ), (AU,VR), (AU,VS), (AU,VT), (AU,VU), (AU,VV), (AU,VW), (AU,VX), (AU, VY), (AU,VZ), (AU,WA), (AU,WB), (AU,WC), (AV,VA), (AV,VB), (AV,VC), (AV,VD), (AV,VE), (AV,VF), (AV,VG), (AV,VH), (AV,VI), (AV,VJ), (AV,VK), (AV,VL), (AV,VM), (AV,VN), (AV,VO), (AV,VP), (AV,VQ), (AV,VR), (AV,VS), (AV,VT), (AV,VU), (AV,VV), (AV,VW), (AV,VX), (AV,VY), (AV,VZ), (AV,WA), (AV, WB), (AV,WC), (AW,VA), (AW,VB), (AW,VC), (AW,VD), (AW,VE), (AW,VF), (AW,VG), (AW,VH), (AW, VI), (AW,VJ), (AW,VK), (AW,VL), (AW,VM), (AW,VN), (AW,VO), (AW,VP), (AW,VQ), (AW,VR), (AW,VS), (AW, VT), (AW,VU), (AW,VV), (AW,VW), (AW,VX), (AW,VY), (AW,VZ), (AW,WA), (AW,WB), (AW,WC), (AX,VA), (AX,VB), (AX,VC), (AX,VD), (AX,VE), (AX, VF), (AX,VG), (AX,VH), (AX,VI), (AX,VJ), (AX,VK), (AX,VL), (AX,VM), (AX,VN), (AX,VO), (AX,VP), (AX, VQ), (AX,VR), (AX,VS), (AX,VT), (AX,VU), (AX,VV), (AX,VW), (AX,VX), (AX,VY), (AX,VZ), (AX,WA), (AX,WB), (AX,WC), (AY,VA), (AY,VB), (AY,VC), (AY, VD), (AY,VE), (AY,VF), (AY,VG), (AY,VH), (AY,VI), (AY,VJ), (AY,VK), (AY,VL), (AY,VM), (AY,VN), (AY,VO, (AY,VP), (AY,VQ), (AY,VR), (AY,VS), (AY,VT), (AY,VU), (AY,VV), (AY,VW), (AY,VX), (AY, VY), (AY,VZ), (AY,WA), (AY,WB), (AY,WC), (AZ,VA), (AZ,VB), (AZ,VC), (AZ,VD), (AZ,VE), (AZ,VF), (AZ, VG), (AZ,VH), (AZ,VI), (AZ,VJ), (AZ,VK), (AZ,VL), (AZ,VM), (AZ,VN), (AZ,VO), (AZ,VP), (AZ,VQ), (AZ, VR), (AZ,VS), (AZ,VT), (AZ,VU), (AZ,VV), (AZ,VW), (AZ,VX), (AZ,VY), (AZ,VZ), (AZ,WA), (AZ,WB), (AZ, WC),
  • (BA,VA), (BA,VB), (BA,VC), (BA,VD), (BA,VE), (BA,VF), (BA,VG), (BA,VH), (BA,VI), (BA,VJ), (BA, VK), (BA,VL), (BA,VM), (BA,VN), (BA,VO), (BA,VP), (BA,VQ), (BA,VR), (BA,VS), (BA,VT), (BA,VU), (BA, VV), (BA,VW), (BA,VX), (BA,VY), (BA,VZ), (BA,WA), (BA,WB), (BA,WC), (BB,VA), (BB,VB), (BB,VC), (BB, VD), (BB,VE), (BB,VF), (BB,VG), (BB,VH), (BB,VI), (BB,VJ), (BB,VK), (BB,VL), (BB,VM), (BB,VN), (BB, VO), (BB,VP), (BB,VQ), (BB,VR), (BB,VS), (BB,VT), (BB,VU), (BB,VV), (BB,VW), (BB,VX), (BB,VY), (BB, VZ), (BB,WA), (BB,WB), (BB,WC), (BC,VA), (BC,VB), (BC,VC), (BC,VD), (BC,VE), (BC,VF), (BC,VG), (BC, VH), (BC,VI), (BC,VJ), (BC,VK), (BC,VL), (BC,VM), (BC,VN), (BC,VO), (BC,VP), (BC,VQ), (BC,VR), (BC, VS), (BC,VT), (BC,VU), (BC,UV), (BC,VW), (BC,VX), (BC,VY), (BC,VZ), (BC,WA), (BC,WB), (BC,WC), (BD, VA), (BD,VB), (BD,VC), (BD,VD), (BD,VE), (BD,VF), (BD,VG), (BD,VH), (BD,VI), (BD,VJ), (BD,VK), (BD, VL), (BD,VM), (BD,VN), (BD,VO), (BD,VP), (BD,VQ), (BD,VR), (BD,VS), (BD,VT), (BD,VU), (BD,VV), (BD, VW), (BD,VX), (BD,VY), (BD,VZ), (BD,WA), (BD,WB), (BD,WC), (BE,VA), (BE,VB), (BE,VC), (BE, VD), (BE,VE), (BE,VF), (BE,VG), (BE,VH), (BE,VI), (BE,VJ), (BE,VK), (BE,VL), (BE,VM), (BE,VN), (BE, VO), (BE,VP), (BE,VQ), (BE,VR), (BE,VS), (BE,VT), (BE,VU), (BE,VV), (BE,VW), (BE, VX), (BE,VY), (BE, VZ), (BE,WA), (BE,WB), (BE,WC), (BF,VA), (BF,VB), (BF,VC), (BF,VD), (BF,VE), (BF,VF), (BF,VG), (BF,VH), (BF,VI), (BF,VJ), (BF,VK), (BF,VL), (BF,VM), (BF,VN), (BF,VO), (BF,VP), (BF,VQ), (BF,VR), (BF,VS), (BF,VT), (BF,VU), (BF,VV), (BF,VW), (BF,VX), (BF,VY), (BF,VZ), (BF,WA), (BF,WB), (BF,WC), (BG,VA), (BG, VB), (BG,VC), (BG,VD), (BG,VE), (BG,VF), (BG,VG), (BG,VH), (BG,VI), (BG,VJ), (BG,VK), (BG,VL), (BG, VM), (BG,VN), (BG,VO), (BG,VP), (BG,VQ), (BG,VR), (BG,VS), (BG,VT), (BG,VU), (BG,VV), (BG,VW), (BG, VX), (BG,VY), (BG,VZ), (BG,WA), (BG,WB), (BG,WC), (BH,VA), (BH,VB), (BH,VC), (BH,VD), (BH, VE), (BH,VF), (BH,VG), (BH,VH), (BH,VI), (BH,VJ), (BH,VK), (BH,VL), (BH,VM), (BH,VN), (BH,VO), (BH, VP), (BH,VQ), (BH,VR), (BH,VS), (BH,VT), (BH,VU), (BH,VV), (BH,VW), (BH,VX), (BH,VY), (BH,VZ), (BH, WA), (BH,WB), (BH,WC), (BI,VA), (BI,VB), (BI,VC), (BI,VD), (BI,VE), (BI,VF), (BI,VG), (BI,VH), (BI,VI), (BI,VJ), (BI,VK), (BI,VL), (BI,VM), (BI,VN), (BI,VO), (BI,VP), (BI,VQ), (BI,VR), (BI,VS), (BI,VT), (BI,VU), (BI,VV), (BI,VW), (BI,VX), (BI,VY), (BI,VZ), (BI,WA), (BI,WB), (BI,WC), (BJ,VA), (BJ,VB), (BJ,VC), (BJ,VD), (BJ,VE), (BJ,VF), (BJ,VG), (BJ,VH), (BJ,VI), (BJ,VJ), (BJ,VK), (BJ,VL), (BJ,VM), (BJ,VN), (BJ,VO), (BJ,VP), (BJ,VQ), (BJ,VR), (BJ,VS), (BJ,VT), (BJ,VU), (BJ,VV), (BJ,VW), (BJ,VX), (BJ,VY), (BJ,VZ), (BJ,WA), (BJ,WB), (BJ,WC), (BK,VA), (BK,VB), (BK,VC), (BK, VD), (BK,VE), (BK,VF), (BK,VG), (BK,VH), (BK,VI), (BK,VJ), (BK,VK), (BK,VL), (BK,VM), (BK,VN), (BK, VO), (BK,VP), (BK,VQ), (BK,VR), (BK,VS), (BK,VT), (BK,WU), (BK,VV), (BK,VW), (BK, VX), (BK,VY), (BK,VZ), (BK,WA), (BK,WB), (BK,WC), (BL,VA), (BL, VB), (BL,VC), (BL,VD), (BL,VE), (BL,VF), (BL,VG), (BL,VH), (BL,VI), (BL,VJ), (BL,VK), (BL,VL), (BL,VM), (BL,VN), (BL,VO), (BL,VP), (BL,VQ), (BL, VR), (BL,VS), (BL,VT), (BL,VU), (BL,VV), (BL,VW), (BL,VX), (BL,VY), (BL,VZ), (BL,WA), (BL,WB), (BL, WC), (BM,VA), (BM,VB), (BM,VC), (BM,VD), (BM,VE), (BM,VF), (BM,VG), (BM,VH), (BM,VI), (BM,VJ), (BM,VK), (BM,VL), (BM,VM), (BM,VN), (BM,VO), (BM,VP), (BM,VQ), (BM,VR), (BM,VS), (BM,VT), (BM,VU), (BM,VV), (BM,VW), (BM,VX), (BM,VY), (BM,VZ), (BM,WA), (BM,WB), (BM,WC), (BN,VA), (BN,VB), (BN,VC), (BN,VD), (BN,VE), (BN, VF), (BN,VG), (BN,VH), (BN,VI), (BN,VJ), (BN,VK), (BN,VL), (BN,VM), (BN,VN), (BN,VO), (BN,VP), (BN, VQ), (BN,VR), (BN,VS), (BN,VT), (BN,VU), (BN,VV), (BN,VW), (BN,VX), (BN,VY), (BN,VZ), (BN,WA), (BN, WB), (BN,WC), (BO,VA), (BO,VB), (BO,VC), (BO,VD), (BO,VE), (BO,VF), (BO,VG), (BO,VH), (BO,VI), (BO, VJ), (BO,VK), (BO,VL), (BO,VM), (BO,VN), (BO,VO), (BO,VP), (BO,VQ), (BO,VR), (BO,VS), (BO,VT), (BO, VU), (BO,VV), (BO,VW), (BO,VX), (BO,VY), (BO,VZ), (BO,WA), (BO,WB), (BO,WC), (BP,VA), (BP,VB), (BP, VC), (BP,VD), (BP,VE), (BP,VF), (BP,VG), (BP,VH), (BP, VI), (BP,VJ), (BP,VK), (BP,VL), (BP,VM), (BP,VN), (BP, VO), (BP,VP), (BP,VQ), (BP,VR), (BP,VS), (BP,VT), (BP, VU), (BP,VV), (BP,VW), (BP,VX), (BP,VY), (BP,VZ), (BP,WA), (BP,WB), (BP,WC), (BQ,VA), (BQ,VB), (BQ, VC), (BQ,VD), (BQ,VE), (BQ,VF), (BQ,VG), (BQ,VH), (BQ,VI), (BQ,VJ), (BQ,VK), (BQ,VL), (BQ,VM), (BQ, VN), (BQ,VO), (BQ,VP), (BQ,VQ), (BQ,VR), (BQ,VS), (BQ,VT), (BQ,WU), (BQ,VV), (BQ,VW), (BQ, VX), (BQ,VY), (BQ,VZ), (BQ,WA), (BQ,WB), (BQ,WC), (BR, VA), (BR,VB), (BR,VC), (BR,VD), (BR,VE), (BR,VF), (BR,VG), (BR,VH), (BR,VI), (BR,VJ), (BR,VK), (BR, VL), (BR,VM), (BR,VN), (BR,VO), (BR,VP), (BR,VQ), (BR,VR), (BR,VS), (BR,VT), (BR,VU), (BR,VV), (BR, VW), (BR,VX), (BR,VY), (BR,VZ), (BR,WA), (BR,WB), (BR,WC), (BS,VA), (BS,VB), (BS,VC), (BS,VD), (BS, VE), (BS,VF), (BS,VG), (BS,VH), (BS,VI), (BS,VJ), (BS, VK), (BS,VL), (BS,VM), (BS,VN), (BS,VO), (BS,VP), (BS,VQ), (BS,VR), (BS,VS), (BS,VT), (BS,VU), (BS,VV), (BS,VW), (BS,VX), (BS,VY), (BS,VZ), (BS, WA), (BS,WB), (BS,WC), (BT,VA), (BT,VB), (BT,VC), (BT,VD), (BT,VE), (BT,VF), (BT,VG), (BT,VH), (BT,VI), (BT,VJ), (BT,VK), (BT,VL), (BT,VM), (BT,VN), (BT,VO), (BT,VP), (BT,VQ), (BT,VR), (BT,VS), (BT,VT), (BT,VU), (BT,VV), (BT,VW), (BT,VX), (BT, VY), (BT,VZ), (BT,WA), (BT,WB), (BT,WC), (BU,VA), (BU,VB), (BU,VC), (BU,VD), (BU,VE), (BU,VF), (BU, VG), (BU,VH), (BU,VI), (BU,VJ), (BU,VK), (BU,VL), (BU,VM), (BU,VN), (BU,VO), (BU,VP), (BU,VQ), (BU, VR), (BU,VS), (BU,VT), (BU,VU), (BU,VV), (BU,VW), (BU,VX), (BU,VY), (BU,VZ), (BU,WA), (BU,WB), (BU, WC), (BV,VA), (BV,VB), (BV,VC), (BV VD), (BV,VE), (BV,VF), (BV,VG), (BV,VH), (BV,VI), (BV,VJ), (BV,VK), (BV,VL), (BV,VM), (BV,VN), (BV,VO), (BV, VP), (BV,VQ), (BV,VR), (BV,VS), (BV,VT), (BV,VU), (BV,VV), (BV,VW), (BV,VX), (BV,VY), (BV,VZ), (BV, WA), (BV,WB), (BV,WC), (BW,VA), (BW,VB), (BW,VC), (BW,VD), (BW,VE), (BW,VF), (BW,VG), (BW,VH), (BW,VI), (BW,VJ), (BW,VK), (BW,VL), (BW, VM), (BW,VN), (BW,VO), (BW,VP), (BW,VQ), (BW,VR), (BW,VS), (BW,VT), (BW,VU), (BW,VV), (BW,VW), (BW,VX), (BW,VY), (BW,VZ), (BW,WA), (BW,WB), (BW,WC), (BX,VA), (BX,VB), (BX,VC), (BX,VD), (BX,VE), (BX,VF), (BX,VG), (BX,VH), (BX, VI), (BX,VJ), (BX,VK), (BX,VL), (BX,VM), (BX,VN), (BX,VO), (BX,VP), (BX,VQ), (BX,VR), (BX,VS), (BX, VT), (BX,VU), (BX,Vv), (BX,VW), (BX,VX), (BX,VY), (BX,VZ), (BX,WA), (BX,WB), (BX,WC), (BY,VA), (BY, VB), (BY,VC), (BY,VD), (BY,VE), (BY,VF), (BY,VG), (BY,VH), (BY,VI), (BY,VJ), (BY,VK), (BY,VL), (BY,VM), (BY,VN), (BY,VO), (BY,VP), (BY,VQ), (BY, VR), (BY,VS), (BY,VT), (BY,VU), (BY,VV), (BY,VW), (BY,VX), (BY,VY), (BY,VZ), (BY,WA), (BY,WB), (BY, WC), (BZ,VA), (BZ,VB), (BZ,VC), (BZ,VD), (BZ,VE), (BZ,VF), (BZ,VG), (BZ,VH), (BZ,VI), (BZ,VJ), (BZ,VK), (BZ,VL), (BZ,VM), (BZ,VN), (BZ,VO), (BZ, VP), (BZ,VQ), (BZ,VR), (BZ,VS), (BZ,VT), (BZ,VU), (BZ,VW), (BZ,VW), (BZ,VX), (BZ,VY), (BZ,VZ), (BZ, WA), (BZ,WB), (BZ,WC),
  • (CA,VA), (CA,VB), (CA,VC), (CA,VD), (CA,VE), (CA,VF), (CA,VG), (CA,VH), (CA,VI), (CA,VJ), (CA, VK), (CA,VL), (CA,VM), (CA,VN), (CA,VO), (CA,VP), (CA,VQ), (CA,VR), (CA,VS), (CA,VT), (CA,VU), (CA, VV), (CA,VW), (CA,VX), (CA,VY), (CA,VZ), (CA,WA), (CA,WB), (CA,WC), (CB,VA), (CB,VB), (CB,VC), (CB, VD), (CB,VE), (CB,VF), (CB,VG), (CB,VH), (CB,VI), (CB,VJ), (CB,VK, (CB,VL), (CB,VM), (CB,VN), (CB, VO), (CB,VP), (CB,VQ), (CB,VR), (CB,VS), (CB,VT), (CB,VU), (CB,VV), (CB,VW), (CB, VX), (CB,VY), (CB, VZ), (CB,WA), (CB,WB), (CB,WC), (CC,VA), (CC,VB), (CC,VC), (CC,VD), (CC,VE), (CC,VF), (CC,VG), (CC, VH), (CC,VI), (CC,VJ), (CC,VK), (CC,VL), (CC,VM), (CC,VN), (CC,VO), (CC,VP), (CC,VQ), (CC,VR), (CC, VS), (CC,VT), (CC,VU), (CC,VV), (CC,VW), (CC, VX), (CC,VY), (CC,VZ), (CC,WA), (CC,WB), (CC,WC), (CD, VA), (CD,VB), (CD,VC), (CD,VD), (CD,VE), (CD,VF), (CD,VG), (CD,VH), (CD,VI), (CD,VJ), (CD,VK), (CD, VL), (CD,VM), (CD,VN), (CD,VO), (CD,VP), (CD,VQ), (CD,VR), (CD,VS), (CD,VT), (CD,VW), (CD,VV), (CD, VW), (CD, VX), (CD,VY), (CD,VZ), (CD,WA), (CD,WB), (CD,WC), (CE,VA), (CE,VB), (CE,VC), (CE, VD), (CE,VE), (CE,VF), (CE,VG), (CE,VH), (CE,VI), (CE,VJ), (CE,VK), (CE,VL), (CE,VM), (CE,VN), (CE, VO), (CE,VP), (CE,VQ), (CE,VR), (CE,VS), (CE,VT), (CE,VU), (CE,VV), (CE,VW), (CE, VX), (CE,VY), (CE, VZ), (CE,WA), (CE,WB), (CE,WC), (CF,VA), (CF,VB), (CF,VC), (CF,VD), (CF,VE), (CF,VF), (CF,VG), (CF,VH), (CF,VI), (CF,VJ), (CF,VK), (CF,VL), (CF,VM), (CF,VN), (CF,VO), (CF,VP), (CF,VQ), (CF,VR), (CF,VS), (CF,VT), (CF,VU), (CF,VV), (CF,VW), (CF,VX), (CF,VY), (CF,VZ), (CF,WA), (CF,WB), (CF,WC), (CG,VA), (CG, VB), (CG,VC), (CG,VD), (CG,VE), (CG,VF), (CG,VG), (CG,VH), (CG,VI), (CG,VJ), (CG,VK), (CG,VL), (CG, VM), (CG,VN), (CG,VO), (CG,VP), (CG,VQ), (CG,VR), (CG,VS), (CG,VT), (CG,VU), (CG,VV), (CG,VW), (CG, VX), (CG,VY), (CG,VZ), (CG,WA), (CG,WB), (CG,WC), (CH,VA), (CH,VB), (CH,VC), (CH,VD), (CH, VE), (CH,VF), (CH,VG), (CH,VH), (CH,VI), (CH,VJ), (CH,VK), (CH,VL), (CH,VM), (CH,VN), (CH,VO), (CH, VP), (CH,VQ), (CH,VR), (CH,VS), (CH,VT), (CH,VU), (CH,VV), (CH,VW), (CH,VX), (CH,VY), (CH,VZ), (CH, WA), (CH,WB), (CH,WC), (CI,VA), (CI,VB), (CI,VC), (CI,VD), (CI,VE), (CI,VF), (CI,VG), (CI,VH), (CI,VI), (CI,VJ), (CI,VK), (CI,VL), (CI,VM), (CI,VN), (CI,VO), (CI,VP), (CI,VQ), (CI,VR), (CI,VS), (CI,VT), (CI,WU), (CI,VV), (CI,VW), (CI,VX), (CI,VY), (CI,VZ), (CI,WA), (CI,WB), (CI,WC), (CJ,VA), (CJ,VB), (CJ,VC), (CJ,VD), (CJ,VE), (CJ,VF), (CJ,VG), (CJ,VH), (CJ,VI), (CJ,VJ), (CJ,VK), (CJ,VL), (CJ,VM), (CJ,VN), (CJ,VO), (CJ,VP), (CJ,VQ), (CJ,VR), (CJ,VS), (CJ,VT), (CJ,VU), (CJ,VV), (CJ,VW), (CJ,VX), (CJ,VY), (CJ,VZ), (CJ,WA), (CJ,WB), (CJ,WC), (CK,VA), (CK,VB), (CK,VC), (CK, VD), (CK,VE), (CK,VF), (CK,VG), (CK,VH), (CK,VI), (CK,VJ), (CK,VK), (CK,VL), (CK,VM), (CK,VN), (CK, VO), (CK,VP), (CK,VQ), (CK,VR), (CK,VS), (CK,VT), (CK,VU), (CK,VV), (CK,VW), (CK, VX), (CK,VY), (CK, VZ), (CK,WA), (CK,WB), (CK,WC), (CL,VA), (CL,VB), (CL,VC), (CL,VD), (CL,VE), (CL,VF), (CL,VG), (CL, VH), (CL,VI), (CL,VJ), (CL,VK), (CL,VL), (CL,VM), (CL,VN), (CL,VO), (CL,VP), (CL,VQ), (CL,VR), (CL, VS), (CL,VT), (CL,VU), (CL,UV), (CL,VW), (CL,VX), (CL,VY), (CL,VZ), (CL,WA), (CL,WB), (CL,WC), (CM, VA), (CM,VB), (CM,VC), (CM,VD), (CM,VE), (CM,VF), (CM,VG), (CM,VH), (CM,VI), (CM,VJ), (CM, VK), (CM,VL), (CM,VM), (CM,VN), (CM,VO), (CM, VP), (CM,VQ), (CM,VR), (CM,VS), (CM,VT), (CM,VU), (CM,VV), (CM,VW), (CM,VX), (CM,VY), (CM,VZ), (CM,WA), (CM,WB), (CM,WC), (CN,VA), (CN,VB), (CN,VC), (CN,VD), (CN,VE), (CN,VF), (CN, VG), (CN,VH), (CN,VI), (CN,VJ), (CN,VK), (CN,VL), (CN,VM), (CN,VN), (CN,VO), (CN,VP), (CN,VQ), (CN, VR), (CN,VS), (CN,VT), (CN,VU), (CN,VV), (CN,VW), (CN,VX), (CN,VY), (CN,VZ), (CN,WA), (CN,WB), (CN, WC), (CO,VA), (CO,VB), (CO,VC), (CO,VD), (CO,VE), (CO,VF), (CO,VG), (CO,VH), (CO,VI), (CO,VJ), (CO, VK), (CO,VL), (CO,VM), (CO,VN), (CO,VO), (CO,VP), (CO,VQ), (CO,VR), (CO,VS), (CO,VT), (CO,VU), (CO, VV), (CO,VW), (CO,VX), (CO,VY), (CO,VZ), (CO,WA), (CO,WB), (CO,WC), (CP,VA), (CP,VB), (CP,VC), (CP, VD), (CP,VE), (CP,VF), (CP,VG), (CP,VH), (CP,VI), (CP, VJ), (CP,VK), (CP,VL), (CP,VM), (CP,VN), (CP,VO), (CP, VP), (CP,VQ), (CP,VR), (CP,VS), (CP,VT), (CP,VU), (CP, VV), (CP,VW), (CP,VX), (CP,VY), (CP,VZ), (CP,WA), (CP,WB), (CP,WC), (CQ,VA), (CQ,VB), (CQ,VC), (CQ, VD), (CQ,VE), (CQ,VF), (CQ,VG), (CQ,VH), (CQ,VI), (CQ,VJ), (CQ,VK), (CQ,VL), (CQ,VM), (CQ,VN), (CQ, VO), (CQ,VP), (CQ,VQ), (CQ,VR), (CQ,VS), (CQ,VT), (CQ,VU), (CQ,VV), (CQ,VW), (CQ,VX), (CQ,VY), (CQ, VZ), (CQ,WA), (CQ,WB), (CQ,WC), (CR,VA), (CR,VB), (CR,VC), (CR,VD), (CR,VE), (CR,VF), (CR,VG), (CR, VH), (CR,VI), (CR,VJ), (CR,VK), (CR,VL), (CR,VM), (CR,VN), (CR,VO), (CR,VP), (CR,VQ), (CR,VR), (CR, VS), (CR,VT), (CR,VU), (CR,VV), (CR,VW), (CR,VX), (CR,VY), (CR,VZ), (CR,WA), (CR,WB), (CR,WC), (CS, VA), (CS,VB), (CS,VC), (CS,VD), (CS,VE), (CS,VF), (CS,VG), (CS,VH), (CS,VI), (CS,VJ), (CS,VK), (CS,VL), (CS,VM), (CS,VN), (CS,VO), (CS,VP), (CS,VQ), (CS, VR), (CS,VS), (CS,VT), (CS,VU), (CS,VV), (CS,VW), (CS,VX), (CS,VY), (CS,VZ), (CS,WA), (CS,WB), (CS, WC), (CT,VA), (CT,VB), (CT,VC), (CT,VD), (CT,VE), (CT,VF), (CT,VG), (CT,VH), (CT,VI), (CT,VJ), (CT,VK), (CT,VL), (CT,VM), (CT,VN), (CT,VO), (CT,VP), (CT,VQ), (CT,VR), (CT,VS), (CT,VT), (CT,VU), (CT,Vv), (CT,VW), (CT,VX), (CT,VY), (CT,VZ), (CT,WA), (CT,WB), (CT,WC), (CU,VA), (CU,VB), (CU, VC), (CU,VD), (CU,VE), (CU,VF), (CU,VG), (CU,VH), (CU,VI), (CU,VJ), (CU,VK), (CU,VL), (CU,VM), (CU, VN), (CU,VO), (CU,VP), (CU,VQ), (CU,VR), (CU,VS), (CU,VT), (CU,VU), (CU,VV), (CU,VW), (CU,VX), (CU, VY), (CU,VZ), (CU,WA), (CU,WB), (CU,WC), (CV,VA), (CV,VB), (CV,VC), (CV,VD), (CV,VE), (CV,VF), (CV, VG), (CV,VH), (CV,VI), (CV,VJ), (CV,VK), (CV,VL), (CV,VM), (CV,VN), (CV,VO), (CV,VP), (CV,VQ), (CV, VR), (CV,VT), (CV,VU), (CV,VV), (CV,VW), (CV,VX), (CV,VY), (CV,VZ), (CV,WA), (CV,WB), (CV,WC), (CW, VA), (CW,VB), (CW,VC), (CW,VD), (CW,VE), (CW,VF), (CW,VG), (CW,VH), (CW,VI), (CW,VJ), (CW,VK), (CW, VL), (CW,VM), (CW,VN), (CW,VO), (CW,VP), (CW,VQ), (CW,VR), (CW,VS), (CW,VT), (CW,VU), (CW,VV), (CW,VW), (CW,VX), (CW,VY), (CW,VZ), (CW,WA), (CW,WB), (CW,WC), (CX,VA), (CX,VB), (CX,VC), (CX,VD), (CX,VE), (CX,VF), (CX,VG), (CX, VH), (CX,VI), (CX,VJ), (CX,VK), (CX,VL), (CX,VM), (CX,VN), (CX,VO), (CX,VP), (CX,VQ), (CX,VR), (CX, VS), (CX,VT), (CX,VU), (CX,VV), (CX,VW), (CX,VX), (CX,VY), (CX,VZ), (CX,WA), (CX,WB), (CX,WC), (CY, VA), (CY,VB), (CY,VC), (CY,VD), (CY,VE), (CY,VF), (CY,VG), (CY,VH), (CY,VI), (CY,VJ), (CY,VK), (CY,VL), (CY,VM), (CY,VN), (CY,VO), (CYXP), (CY, VQ), (CY,VR), (CY,VS), (CY,VT), (CY,VU), (CY,VV), (CY,VW), (CY,VX), (CY,VY), (CY,VZ), (CY,WA), (CY, WB), (CY,WC), (CZ,VA), (CZ,VB), (CZ,VC), (CZ,VD), (CZ,VE), (CZ,VF), (CZ,VG), (CZ,VH), (CZ,VI), (CZ,VJ), (CZ,VK), (CZ,VL), (CZ,VM), (CZ,VN), (CZ, VO), (CZ,VP), (CZ,VQ), (CZ,VR), (CZ,VS), (CZ,VT), (CZ,VU), (CZ,VV), (CZ,VW), (CZ, VX), (CZ,VY), (CZ, VZ), (CZ,WA), (CZ,WB), (CZ,WC),
  • (DA,VA), (DN,VB), (DN,VC), (DN,VD), (DA,VE), (DA,VF), (DN,VG), (DN,VH), (DA,VI), (DA,VJ), (DA, VK), (DA,VL), (DN,VM), (DA,VN), (DA,VO), (DA,VP), (DA,VQ), (DA,VR), (DA,VS), (DA,VT), (DA,WU), (DA, VV), (DA,VW), (DA, VX), (DA,VY), (DA,VZ), (DA,WA), (DA,WB), (DA,WC), (DB,VA), (DB,VB), (DB,VC), (DB,VD), (DB,VE), (DB,VF), (DB,VG), (DB, VH), (DB,VI), (DB,VJ), (DB,VK), (DB,VL), (DB,VM), (DB,VN), (DB,VO), (DB,VP), (DB,VQ), (DB,VR), (DB, VS), (DB,VT), (DB,VU), (DB,VV), (DB,VW), (DB,VX), (DB,VY), (DB,VZ), (DB,WA), (DB,WB), (DB,WC), (DC,VA), (DC,VA), (DC,VB), (DC,VB), (DC,VC), (DC, VD), (DC,VE), (DC,VF), (DN,VG), (DN,VH), (DC,VI), (DG,VJ), (DC,VK), (DC,VL), (DC,VM), (DC,VN), (DC, VO), (DC,VP), (DC,VQ), (DC,VR), (DC,VS), (DC,VT), (DC,VU), (DC,VV), (DC,VW), (DC,VX), (DC,VY), (DC, VZ), (DC,WA), (DC,WB), (DC,WC), (DD,VC), (DD,VD), (DD,VE), (DD,VF), (DD,VG), (DD,VH), (DD, VI), (DD,VJ), (DD,VK), (DD,VL), (DD,VM), (DD,VN), (DD,VO), (DD,VP), (DD,VQ), (DD,VR), (DD,VS), (DD, VT), (DD,VU), (DD,VV), (DD,VW), (DD, VX), (DD,VY), (DD,VZ), (DD,WA), (DD,WB), (DD,WC), (DE,VA), (DE,VB), (DE,VC), (DE,VD), (DE,VE), (DE, VF), (DE,VG), (DE,VH), (DE,VI), (DE,VJ), (DE,VK), (DE,VL), (DE,VM), (DE,VN), (DE,VO), (DE,VP), (DE, VQ), (DE,VR), (DE,VS), (DE,VT), (DE,VU), (DE,VV), (DE,VW), (DE, VX), (DE,VY), (DE,VZ), (DE,WA), (DE, WB), (DE,WC), (DF,VA), (DF,VB), (DF,VC), (DF,VD), (DF,VE), (DF,VF), (DF,VG), (DF,VH), (DF,VI), (DF,VJ), (DF,VK), (DF,VL), (DF,VM), (DF,VN), (DF,VO), (DF, VP), (DF,VQ), (DF,VR), (DF,VS), (DF,VT), (DF,VU), (DF,VV), (DF,VW), (DF,VX), (DF,VY), (DF,VZ), (DF, WA), (DF,WB), (DF,WC), (DG,VA), (DG,VB), (DG,VC), (DG,VD), (DG,VE), (DG,VF), (DG,VG), (DG,VH), (DG, VI), (DG,VJ), (DG,VK), (DG,VL), (DG,VM), (DG,VN), (DG,VO), (DG,VP), (DG,VQ), (DG,VR), (DG,VS), (DG, VT), (DG,VU), (DG,VV), (DG,VW), (DG,VX), (DG,VY), (DG,VZ), (DG,WA), (DG,WB), (DG,WC), (DH,VA), (DH,VB), (DH,VC), (DH,VD), (DH,VE), (DH, VF), (DH,VG), (DH,VH), (DH,VI), (DH,VJ), (DH,VK), (DH,VL), (DH,VM), (DH,VN), (DH,VO), (DH,VP), (DH, VQ), (DH,VR), (DH,VS), (DH,VT), (DH,VU), (DH,VV), (DH,VW), (DH,VX), (DH,VY), (DH,VZ), (DH,WA), (DH,WB), (DH,WC), (DI,VA), (DI,VB), (DI,VC), (DI, VD), (DI,VE), (DI,VF), (DI,VG), (DI,VH), (DI,VI), (DI, VJ), (DI,VK), (DI,VL), (DI,VM), (DI,VN), (DI,VO), (DI, VP), (DI,VQ), (DI,VR), (DI,VS), (DI,VT), (DI,VU), (DI, VW), (DI,VW), (DI,VX), (DI,VY), (DI,VZ), (DI,WA), (DI,WB), (DI,WC), (DJ,VA), (DJ,VB), (DJ,VC), (DJ,VD), (DJ,VE), (DJ,VF), (DJ,VG), (DJ,VH), (DJ,VI), (DJ,VJ), (DJ,VK), (DJ,VL), (DJ,VM), (DJ,VN), (DJ,VO), (DJ,VP), (DJ,VQ), (DJ,VR), (DJ,VS), (DJ,VT), (DJ,VU), (DJ,VV), (DJ,VW), (DJ,VX), (DJ,VY), (DJ,VZ), (DJ,WA), (DJ,WB), (DJ,WC), (DK,VA), (DK,VB), (DK, VC), (DK,VD), (DK,VE), (DK,VF), (DK,VG), (DK,VH), (DK,VI), (DK,VJ), (DK,VK), (DK,VL), (DN,VM), (DK, VN), (DK,VO), (DK,VP), (DK,VQ), (DK,VR), (DK,VS), (DN,VT), (DK,VU), (DK,VV), (DK,VW), (DK, VX), (DK,VY), (DK,VZ), (DK,WA), (DK,WB), (DK,WC), (DL,VA), (DL,VB), (DL,VC), (DL,VD), (DL,VE), (DL, VF), (DL,VG), (DN,VH), (DL,VI), (DL,VJ), (DL,VK), (DL,VL), (DL,VM), (DL,VN), (DL,VO), (DL,VP), (DL, VQ), (DL,VR), (DL,VS), (DL,VT), (DL,VU), (DL,VV), (DL,VW), (DL,VX), (DL,VY), (DL,VZ), (DL,WA), (DL, WB), (DL,WC), (DM,VA), (DM,VB), (DM,VC), (DM, VD), (DM,VE), (DM,VF), (DM,VG), (DM,VH), (DM, VI), (DM,VJ), (DM,VK), (DM,VL), (DM,VM), (DM,VN), (DM,VO), (DM,VP), (DM,VQ), (DM,VR), (DM,VS), (DM,VT), (DM,VU), (DM,VV), (DM,VW), (DM,VX), (DM,VY), (DM,VZ), (DM,WA), (DM,WB), (DM,WC), (DN,VA), (DN,VB), (DN,VC), (DN,VD), (DN,VE), (DN,VF), (DN,VG), (DN,VH), (DN,VI), (DN, VJ), (DN,VK), (DN,VL), (DN,VM), (DN,VN), (DN,VO), (DN,VP), (DN,VQ), (DN,VR), (DN,VS), (DN,VT), (DN, VU), (DN,VV), (DN,VW), (DN, VX), (DN,VY), (DN,VZ), (DN,WA), (DN,WB), (DN,WC), (DO,VA), (DO,VB), (DO,VC), (DO,VD), (DO,VE), (DO,VF), (DO, VG), (DO,VH), (DO,VI), (DO,VJ), (DO,VK), (DO,VL), (DO,VM), (DO,VN), (DO,VO), (DO,VP), (DO,VQ), (DO,VR), (DO,VS), (DO,VT), (DO,VU), (DO,VV), (DO, VW), (DO,VX), (DO,VY), (DO,VZ), (DO,WA), (DO,WB), (DO,WC), (DP,VA), (DP,VB), (DP,VC), (DP, VD), (DP,VE), (DP,VF), (DP,VG), (DP,VH), (DP,VI), (DP, VJ), (DP,VK), (DP,VL), (DP,VM), (DP,VN), (DP,VO), (DP,VP), (DP,VQ), (DP,VR), (DP,VS), (DP,VT), (DP,VU), (DP,VV), (DP,VW), (DP,VX), (DP,VY), (DP,VZ), (DP,WA), (DP,WB), (DP,WC), (DQ,VA), (DQ,VB), (DQ, VC), (DQ,VD), (DQ,VE), (DQ,VF), (DQ,VG), (DQ,VH), (DQ,VI), (DQ,VJ), (DQ,VK), (DQ,VL), (DQ,VM), (DQ, VN), (DQ,VO), (DQ,VP), (DQ,VQ), (DQ,VR), (DQ,VS), (DQ,VT), (DQ,VU), (DQ,VV), (DQ,VW), (DQ,VX), (DQ,VY), (DQ,VZ), (DQ,WA), (DQ,WB), (DQ,WC), (DR,VA), (DR,VB), (DR,VC), (DR,VD), (DR,VE), (DR, VF), (DR,VG), (DR,VH), (DR,VI), (DR,VJ), (DR,VK), (DR,VL), (DR,VM), (DR,VN), (DR,VO), (DR,VP), (DR, VQ), (DR,VR), (DR,VS), (DR,VT), (DR,VU), (DR,VV), (DR,VW), (DR,VX), (DR,VY), (DR,VZ), (DR,WA), (DR, WB), (DR,WC), (DS,VA), (DS,VB), (DS,VC), (DS,VD), (DS,VE), (DS,VF), (DS,VG), (DS,VH), (DS,VI), (DS,VJ), (DS,VK), (DS,VL), (DS,VM), (DS,VN), (DS, VO), (DS,VP), (DS,VQ), (DS,VR), (DS,VS), (DS,VT), (DS,VU), (DS,VV), (DS,VW), (DS,VX), (DS,VY), (DS, VZ), (DS,WA), (DS,WB), (DS,WC), (DT,VA), (DT,VB), (DT,VC), (DT,VD), (DT,VE), (DT,VF), (DT,VG), (DT, VH), (DT,VI), (DT,VJ), (DT,VK), (DT,VL), (DT,VM), (DT,VN), (DT,VO), (DT,VP), (DT,VQ), (DT,VR), (DT, VS), (DT,VT), (DT,VU), (DT,VV), (DT,VW), (DT,VX), (DT,VY), (DT,VZ), (DT,WA), (DT,WB), (DT,WC), (DU, VA), (DU,VB), (DU,VC), (DU,VD), (DU,VE), (DU,VF), (DU,VG), (DU,VH), (DU,VI), (DU,VJ), (DU,VK), (DU, VL), (DU,VM), (DU,VN), (DU,VO), (DU,VP), (DU,VQ), (DU,VR), (DU,VS), (DN,VT), (DU,VU), (DU,VV), (DU, VW), (DU,VX), (DU,VY), (DU,VZ), (DU,WA), (DU,WB), (DU,WC), (DV,VA), (DV,VB), (DV,VC), (DV, VD), (DV,VE), (DV,VF), (DV,VG), (DV,VH), (DV,VI), (DV,VJ), (DV,VK), (DV,VL), (DV,VM), (DV,VN), (DV, VO), (DV,VP), (DV,VQ), (DV,VR), (DV,VS), (DV,VT), (DV,VU), (DV,VV), (DV,VW), (DV,VX), (DV,VY), (DV, VZ), (DV,WA), (DV,WB), (DV,WC), (DW,VA), (DW,VB), (DW,VC), (DW,VD), (DW,VE), (DW,VF), (DW,VG), (DW,VH), (DW,VI), (DW,VJ), (DW,VK), (DW,VL), (DW, VM), (DW,VN), (DW,VO), (DW,VP), (DW,VQ), (DW,VR), (DW,VS), (DW,VT), (DW,VU), (DW,VV), (DW,VW), (DW,VX), (DW,VY), (DW,VZ), (DW,WA), (DW,WB), (DW,WC), (DX,VA), (DX,VB), (DX,VC), (DX,VD), (DX,VE), (DX,VF), (DX,VG), (DX,VH), (DX, VI), (DX,VJ), (DX,VK), (DX,VL), (DX,VM), (DX,VN), (DX,VO), (DX,VP), (DX,VQ), (DX,VR), (DX,VS), (DX, VT), (DX,VU), (DX,VV), (DX,VW), (DX, VX), (DX,VY), (DX,VZ), (DX,WA), (DX,WB), (DX,WC), (DY,VA), (DY,VB), (DY,VC), (DY,VD), (DY,VE), (DY, VF), (DY,VG), (DY,VH), (DY,VI), (DY,VJ), (DY,VK), (DY,VL), (DY,VM), (DY,VN), (DY,VO), (DY,VP), (DY, VQ), (DY,VR), (DY,VS), (DY,VT), (DY,VU), (DY,VV), (DY,VW), (DY,VX), (DY,VY), (DY,VZ), (DY,WA), (DY, WB), (DY,WC), (DZ,VA), (DZ,VB), (DZ,VC), (DZ,VD), (DZ,VE), (DZ,VF), (DZ,VG), (DZ,VH), (DZ,VI), (DZ, VJ), (DZ,VK), (DZ,VL), (DZ,VM), (DZ,VN), (DZ,VO), (DZ,VP), (DZ,VQ), (DZ,VR), (DZ,VS), (DZ,VT), (DZ, VU), (DZ,VV), (DZ,VW), (DZ,VX), (DZ,VY), (DZ,VZ), (DZ,WA), (DZ,WB), (DZ,WC),
  • (EA,VA), (EA,VB), (EA,VC), (EA,VD), (EA,VE), (EA,VF), (EA,VG), (EA,VH), (EA,VI), (EA,VJ), (EA,VK), (EA, VL), (EA,VM), (EA,VN), (EA,VO), (EA,VP), (EA,VQ), (EA,VR), (EA,VS), (EA,VT), (EA,VU), (EA,VV), (EA, VW), (EA,VX), (EA,VY), (EA,VZ), (EA,WA), (EA,WB), (EA,WC), (EB,VA), (EB,VB), (EB,VC), (EB,VD), (EB, VE), (EB,VF), (EB,VG), (EB,VH), (EB,VI), (EB,VJ), (EB,VK), (EB,VL), (EB,VM), (EB,VN), (EB,VO), (EB, VP), (EB,VQ), (EB,VR), (EB,VS), (EB,VT), (EB,VU), (EB,VV), (EB,VW), (EB,VX), (EB,VY), (EB,VZ), (EB, WA), (EB,WB), (EB,WC), (EC,VA), (EC,VA), (EC,VB), (EC,VB), (EC,VC), (EC,VD), (EC,VE), (EC,VF), (EC, VG), (EC,VH), (EC,VI), (EC,VJ), (EC,VK), (EC,VL), (EC,VM), (EC,VN), (EC,VO), (EC,VP), (EC,VQ), (EC, VR), (EC,VS), (EC,VT), (EC,VU), (EC,VV), (EC,VW), (EC,VX), (EC,VY), (EC,VZ), (EC,WA), (EC,WB), (EC, WC), (ED,VC), (ED,VD), (ED,VE), (ED,VF), (ED,VG), (ED,VH), (ED,VI), (ED,VJ), (ED,VK), (ED,VL), (ED, VM), (ED,VN), (ED,VO), (ED,VP), (ED,VQ), (ED,VR), (ED,VS), (ED,VT), (ED,VU), (ED,VV), (ED,VW), (ED, VX), (ED,VY), (ED,VZ), (ED,WA), (ED,WB), (ED,WC), (EE,VA), (EE,VB), (EE,VC), (EE,VD), (EE,VE), (EE,VF), (EE,VG), (EE,VH), (EE,VI), (EE,VJ), (EE,VK), (EE,VL), (EE,VM), (EE,VN), (EE,VO), (EE,VP), (EE, VQ), (EE,VR), (EE,VS), (EE,VT), (EE,VU), (EE,VV), (EE,VW), (EE,VX), (EE,VY), (EE,VZ), (EE,WA), (EE, WB), (EE,WC), (EF,VA), (EF,VB), (EF,VC), (EF,VD), (EF,VE), (EF,VF), (EF,VG), (EF,VH), (EF,VI), (EF,VJ), (EF,VK), (EF,VL), (EF,VM), (EF,VN), (EF,VO), (EF,VP), (EF,VQ), (EF,VR), (EF,VS), (EF,VT), (EF,VU), (EF,VV), (EF,VW), (EF,VX), (EF,VY), (EF,VZ), (EF,WA), (EF,WB), (EF,WC), (EG,VA), (EG,VB), (EG,VC), (EG, VD), (EG,VE), (EG,VF), (EG,VG), (EG,VH), (EG,VI), (EG,VJ), (EG,VK), (EG,VL), (EG,VM), (EG,VN), (EG, VO), (EG,VP), (EG,VQ), (EG,VR), (EG,VS), (EG,VT), (EG,VU), (EG,VV), (EG,VW), (EG,VX), (EG,VY), (EG, VZ), (EG,WA), (EG,WB), (EG,WC), (EH,VA), (EH,VB), (EH,VC), (EH,VD), (EH,VE), (EH,VF), (EH,VG), (EH, VH), (EH,VI), (EH,VJ), (EH,VK), (EH,VL), (EH,VM), (EH,VN), (EH,VO), (EH,VP), (EH,VQ), (EH,VR), (EH, VS), (EH,VT), (EH,VU), (EH,VV), (EH,VW), (EH,VX), (EH,VY), (EH,VZ), (EH,WA), (EH,WB), (EH,WC), (EI, VA), (EI,VB), (EI,VC), (EI,VD), (EI,VE), (EI,VF), (EI, VG), (EI,VH), (EI,VI), (EI,VJ), (EI,VK), (EI,VL), (EI, VM), (EI,VN), (EI,VO), (EI,VP), (EI,VQ), (EI,VR), (EI, VS), (EI,VT), (EI,VU), (EI,VV), (EI,VW), (EI,VX), (EI, VY), (EI,VZ), (EI,WA), (EI,WB), (EI,WC), (EJ,VA), (EJ, VB), (EJ,VC), (EJ,VD), (EJ,VE), (EJ,VF), (EJ,VG), (EJ, VH), (EJ,VI), (EJ,VJ), (EJ,VK), (EJ,VL), (EJ,VM), (EJ, VN), (EJ,VO), (EJ,VP), (EJ,VQ), (EJ,VR), (EJ,VS), (EJ, VT), (EJ,VU), (EJ,VV), (EJ,VW), (EJ,VX), (EJ,VY), (EJ, VZ), (EJ,WA), (EJ,WB), (EJ,WC), (EK,VA), (EK,VB), (EK,VC), (EK,VD), (EK,VE), (EK,VF), (EK,VG), (EK, VH), (EK,VI), (EK,VJ), (EK,VK), (EK,VL), (EK,VM), (EK,VN), (EK,VO), (EK,VP), (EK,VQ), (EK,VR), (EK, VS), (EK,VT), (EK,VU), (EK,VW), (EK,VW), (EK,VX), (EK,VY), (EK,VZ), (EK,WA), (EK,WB), (EK,WC), (EL, VA), (EL,VB), (EL,VC), (EL,VD), (EL,VE), (EL,VF), (EL,VG), (EL,VH), (EL,VI), (EL,VJ), (EL,VK), (EL,VL), (EL,VM), (EL,VN), (EL,VO), (EL,VP), (EL,VQ), (EL, VR), (EL,VS), (EL,VT), (EL,VU), (EL,VV), (EL,VW), (EL,VX), (EL,VY), (EL,VZ), (EL,WA), (EL,WB), (EL, WC), (EM,VA), (EM,VB), (EM,VC), (EM,VD), (EM,VE), (EM,VF), (EM,VG), (EM,VH), (EM,VI), (EM, VJ), (EM,VK), (EM,VL), (EM,VM), (EM,VN), (EM,VO), (EM,VP), (EM,VQ), (EM,VR), (EM,VS), (EM, VT), (EM,VU), (EM,VV), (EM,VW), (EM,VX), (EM,VY), (EM,VZ), (EM,WA), (EM,WB), (EM,WC), (EN,VA), (EN,VB), (EN,VC), (EN,VD), (EN,VE), (EN, VF), (EN,VG), (EN,VH), (EN,VI), (EN,VJ), (EN,VK), (EN,VL), (EN,VM), (EN,VN), (EN,VO), (EN,VP), (EN, VQ), (EN,VR), (EN,VS), (EN,VT), (EN,VU), (EN,VV), (EN,VW), (EN,VX), (EN,VY), (EN,VZ), (EN,WA), (EN, WB), (EN,WC), (EO,VA), (EO,VB), (EO,VC), (EO,VD), (EO,VE), (EO,VF), (EO,VG), (EO,VH), (EO,VI), (EO, VJ), (EO,VK), (EO,VL), (EO,VM), (EO,VN), (EO,VO), (EO,VP), (EO,VQ), (EO,VR), (EO,VS), (EO,VT), (EO, VU), (EO,VV), (EO,VW), (EO, VX), (EO,VY), (EO,VZ), (EO,WA), (EO,WB), (EO,WC), (EP,VA), (EP,VB), (EP, VC), (EP,VD), (EP,VE), (EP,VF), (EP,VG), (EP,VH), (EP, VI), (EP,VJ), (EP,VK), (EP,VL), (EP,VM), (EP,VN), (EP, VO), (EP,VP), (EP,VQ), (EP,VR), (EP,VS), (EP,VT), (EP, VU), (EP,VV), (EP,VW), (EP,VX), (EP,VY), (EP,VZ), (EP,WA), (EP,WB), (EP,WC), (EQ,VA), (EQ,VB), (EQ, VC), (EQ,VD), (EQ,VE), (EQ,VF), (EQ,VG), (EQ,VH), (EQ,VI), (EQ,VJ), (EQ,VK), (EQ,VL), (EQ,VM), (EQ, VN), (EQ,VO), (EQ,VP), (EQ,VQ), (EQ,VR), (EQ,VS), (EQ,VT), (EQ,VU), (EQ,VV), (EQ,VW), (EQ, VX), (EQ, VY), (EQ,VZ), (EQ,WA), (EQ,WB), (EQ,WC), (ER,VA), (ER,VB), (ER,VC), (ER,VD), (ER,VE), (ER,VF), (ER, VG), (ER,VH), (ER,VI), (ER,VJ), (ER,VK), (ER,VL), (ER,VM), (ER,VN), (ER,VO), (ER,VP), (ER,VQ), (ER, VR), (ER,VS), (ER,VT), (ER,VU), (ER,VV), (ER,VW), (ER,VX), (ER,VY), (ER,VZ), (ER,WA), (ER,WB), (ER, WC), (ES,VA), (ES,VB), (ES,VC), (ES,VD), (ES,VE), (ES,VF), (ES,VG), (ES,VH), (ES,VI), (ES,VJ), (ES,VK), (ES,VL), (ES,VM), (ES,VN), (ES,VO), (ES,VP), (ES,VQ), (ES,VR), (ES,VS), (ES,VT), (ES,VU), (ES,VV), (ES,VW), (ES,VX), (ES,VY), (ES,VZ), (ES,WA), (ES,WB), (ES,WC), (ET,VA), (ET,VB), (ET, VC), (ET,VD), (ET,VE), (ET,VF), (ET,VG), (ET,VH), (ET,VI), (ET,VJ), (ET,VK), (ET,VL), (ET,VM), (ET,VN), (ET,VO), (ET,VP), (ET,VQ), (ET,VR), (ET,VS), (ET,VT), (ET,VU), (ET,VV), (ET,VW), (ET,VX), (ET,VY), (ET,VZ), (ET,WA), (ET,WB), (ET,WC), (EU,VA), (EU, VB), (EU,VC), (EU,VD), (EU,VE), (EU,VF), (EU,VG), (EU,VH), (EU,VI), (EU,VJ), (EU,VK), (EU,VL), (EU, VM), (EU,VN), (EU,VO), (EU,VP), (EU,VQ), (EU,VR), (EU,VS), (EU,VT), (EU,VU), (EU,VV), (EU,VW), (EU, VX), (EU,VY), (EU,VZ), (EU,WA), (EU,WB), (EU,WC), (EV,VA), (EV,VB), (EV,VC), (EV,VD), (EV,VE), (EV,VF), (EV,VG), (EV,VH), (EV,VI), (EV,VJ), (EV,VK), (EV,VL), (EV,VM), (EV,VN), (EV,VO), (EV,VP), (EV,VQ), (EV,VR), (EV,VS), (EV,VT), (EV,VU), (EV,VV), (EV,VW), (EV,VX), (EV,VY), (EV,VZ), (EV, WA), (EV,WB), (EV,WC), (EW,VA), (EW,VB), (EW,VC), (EW,VD), (EW,VE), (EW,VF), (EW,VG), (EW,VH), (EW, VI), (EW,VJ), (EW,VK), (EW,VL), (EW,VM), (EW,VN), (EW,VO), (EW,VP), (EW,VQ), (EW,VR), (EW,VS), (EW, VT), (EW,VU), (EW,VV), (EW,VW), (EW,VX), (EW,VY), (EW,VZ), (EW,WA), (EW,WB), (EW,WC), (EX,VA), (EX,VB), (EX,VC), (EX,VD), (EX,VE), (EX, VF), (EX,VG), (EX,VH), (EX,VI), (EX,VJ), (EX,VK), (EX,VL), (EX,VM), (EX,VN), (EX,VO), (EX,VP), (EX, VQ), (EX,VR), (EX,VS), (EX,VT), (EX,VU), (EX,VV), (EX,VW), (EX,VX), (EX,VY), (EX,VZ), (EX,WA), (EX, WB), (EX,WC), (EY,VA), (EY,VB), (EY,VC), (EY,VD), (EY,VE), (EY,VF), (EY,VG), (EY,VH), (EY,VI), (EY,VJ), (EYVK), (EY,VL), (EY,VM), (EY,VN), (EY,VO), (EY, VP), (EY,VQ), (EY,VR), (EY,VS), (EY,VT), (EY,VU), (EY,VV), (EY,VW), (EY,VX), (EY,VY), (EY,VZ), (EY, WA), (EY,WB), (EY,WC), (EZ,VA), (EZ,VB), (EZ,VC), (EZ,VD), (EZ,VE), (EZ,VF), (EZ,VG), (EZ,VH), (EZ,VI), (EZ,VJ), (EZ,VK), (EZ,VL), (EZ,VM), (EZ,VN), (EZ,VO), (EZ,VP), (EZ,VQ), (EZ,VR), (EZ,VS), (EZ,VT), (EZ,VU), (EZ,VV), (EZ,VW), (EZ, VX), (EZ,VY), (EZ,VZ), (EZ,WA), (EZ,WB), (EZ,WC),
  • (FA,VA), (FA,VB), (FA,VC), (FA,VD), (FA,VE), (FA,VF), (FA,VG), (FA,VH), (FA,VI), (FA,VJ), (FA,VK), (FA,VL), (FA,VM), (FA,VN), (FA,VO), (FA,VP), (FA,VQ), (FA, VR), (FA,VS), (FA,VT), (FA,VU), (FA,VV), (FA,VW), (FA,VX), (FA,VY), (FA,VZ), (FA,WA), (FA,WB), (FA, WC), (FB,VA), (FB,VB), (FB,VC), (FB,VD), (FB,VE), (FB,VF), (FB,VG), (FB,VH), (FB,VI), (FB,VJ), (FB,VK), (FB,VL), (FB,VM), (FB,VN), (FB,VO), (FB,VP), (FB, VQ), (FB,VR), (FB,VS), (FB,VT), (FB,VU), (FB,VV), (FB,VW), (FB,VX), (FB,VY), (FB,VZ), (FB,WA), (FB, WB), (FB,WC), (FC,VA), (FC,VA), (FC,VB), (FC,VB), (FC,VC), (FC,VD), (FC,VE), (FC,VF), (FC,VG), (FC,VH), (FC,VI), (FC,VJ), (FC,VK), (FC,VL), (FC,VM), (FC,VN), (FC,VO), (FC,VP), (FC,VQ), (FC, VR), (FC,VS), (FC,VT), (FC,VU), (FC,VV), (FC,VW), (FC,VX), (FC,VY), (FC,VZ), (FC,WA), (FC,WB), (FC, WC), (FD,VC), (FD,VD), (FD,VE), (FD,VF), (FD,VG), (FD,VH), (FD,VI), (FD,VJ), (FD,VK), (FD,VL), (FD,VM), (FD,VN), (FD,VO), (FD,VP), (FD,VQ), (FD, VR), (FD,VS), (FD,VT), (FD,WU), (FD,VV), (FD,VW), (FD,VX), (FD,VY), (FD,VZ), (FD,WA), (FD,WB), (FD, WC), (FE,VA), (FE,VB), (FE,VC), (FE,VD), (FE,VE), (FE,VF), (FE,VG), (FE,VH), (FE,VI), (FE,VJ), (FE,VK), (FE,VL), (FE,VM), (FE,VN), (FE,VO), (FE,VP), (FE,VQ), (FE,VR), (FE,VS), (FE,VT), (FE,VU), (FE,VV), (FE,VW), (FE,VX), (FE,VY), (FE,VZ), (FE,WA), (FE,WB), (FE,WC), (FF,VA), (FF,VB), (FF,VC), (FF,VD), (FF,VE), (FF,VF), (FF,VG), (FF,VH), (FF,VI), (FF,VJ), (FF,VK), (FF,VL), (FF,VM), (FF,VN), (FF,VO), (FF,VP), (FF,VQ), (FF,VR), (FF,VS), (FF,VT), (FF,VU), (FF,VV), (FF,VW), (FF,VX), (FF,VY), (FF,VZ), (FF,WA), (FF,WB), (FF,WC), (FG,VA), (FG,VB), (FG, VC), (FG,VD), (FG,VE), (FG,VF), (FG,VG), (FG,VH), (FG,VI), (FG,VJ), (FG,VK), (FG,VL), (FG,VM), (FG,VN), (FG,VO), (FG,VP), (FG,VQ), (FG,VR), (FG, VS), (FG,VT), (FG,VU), (FG,VV), (FG,VW), (FG,VX), (FG,VY), (FG,VZ), (FG,WA), (FG,WB), (FG,WC), (FH, VA), (FH,VB), (FH,VC), (FH,VD), (FH,VE), (FH,VF), (FH,VG), (FH,VH), (FH,VI), (FH,VJ), (FH,VK), (FH,VL), (FH,VM), (FH,VN), (FH,VO), (FH,VP), (FH, VQ), (FH,VR), (FH,VS), (FH,VT), (FH,VU), (FH,VV), (FH,VW), (FH,VX), (FH,VY), (FH,VZ), (FH,WA), (FH, WB), (FH,WC), (FI,VA), (FI,VB), (FI,VC), (FI,VD), (FI, VE), (FI,VF), (FI,VG), (FI,VH), (FI,VI), (FI,VJ), (FI,VK), (FI,VL), (FI,VM), (FI,VN), (FI,VO), (FI,VP), (FI,VQ), (FI,VR), (FI,VS), (FI,VT), (FI,VU), (FI,VV), (FI,VW), (FI,VX), (FI,VY), (FI,VZ), (FI,WA), (FI,WB), (FI,WC), (FJ,VA), (FJ,VB), (FJ,VC), (FJ,VD), (FJ,VE), (FJ,VF), (FJ,VG), (FJ,VH), (FJ,VI), (FJ,VJ), (FJ,VK), (FJ,VL), (FJ, VM), (FJ,VN), (FJ,VO), (FJ,VP), (FJ,VQ), (FJ,VR), (FJ, VS), (FJ,VT), (FJ,VU), (FJ,VV), (FJ,VW), (FJ,VX), (FJ, VY), (FJ,VZ), (FJ,WA), (FJ,WB), (FJ,WC), (FK,VA), (FK,VB), (FK,VC), (FK,VD), (FK,VE), (FK,VF), (FK, VG), (FK,VH), (FK,VI), (FK,VJ), (FK,VK), (FK,VL), (FK,VM), (FK,VN), (FK,VO), (FK,VP), (FK,VQ), (FK, VR), (FK,VS), (FK,VT), (FK,VU), (FK,VV), (FK,VW), (FK,VX), (FK,VY), (FK,VZ), (FK,WA), (FK,WB), (FK, WC), (FL,VA), (FL,VB), (FL,VC), (FL,VD), (FL,VE), (FL,VF), (FL,VG), (FL,VH), (FL,VI), (FL,VJ), (FL,VK), (FL,VL), (FL,VM), (FL,VN), (FL,VO), (FL,VP), (FL,VQ), (FL,VR), (FL,VS), (FL,VT), (FL,VU), (FL,VV), (FL,VW), (FL,VX), (FL,VY), (FL,VZ), (FL,WA), (FL,WB), (FL,WC), (FM,VA), (FM,VB), (FM, VC), (FM,VD), (FM,VE), (FM,VF), (FM,VG), (FM,VH), (FM,VI), (FM,VJ), (FM,VK), (FM,VL), (FM,VM), (FM, VN), (FM,VO), (FM,VP), (FM,VQ), (FM,VR), (FM,VS), (FM,VT), (FM,VU), (FM,VV), (FM,VW), (FM,VX), (FM,VY), (FM,VZ), (FM,WA), (FM,WB), (FM,WC), (FN,VA), (FN,VB), (FN,VC), (FN,VD), (FN,VE), (FN, VF), (FN,VG), (FN,VH), (FN,VI), (FN,VJ), (FN,VK), (FN,VL), (FN,VM), (FN,VN), (FN,VO), (FN,VP), (FN, VQ), (FN,VR), (FN,VS), (FN,VT), (FN,VU), (FN,VV), (FN,VW), (FN,VX), (FN,VY), (FN,VZ), (FN,WA), (FN, WB), (FN,WC), (FO,VA), (FO,VB), (FO,VC), (FO,VD), (FO,VE), (FO,VF), (FO,VG), (FO,VH), (FO,VI), (FO,VJ), (FO,VK), (FO,VL), (FO,VM), (FO,VN), (FO, VO), (FO,VP), (FO,VQ), (FO,VR), (FO,VS), (FO,VT), (FO,VU), (FO,VV), (FO,VW), (FO,VX), (FO,VY), (FO, VZ), (FO,WA), (FO,WB), (FO,WC), (FP,VA), (FP,VB), (FP,VC), (FP,VD), (FP,VE), (FP,VF), (FP,VG), (FP,VH), (FP,VI), (FP,VJ), (FP,VK), (FP,VL), (FP,VM), (FP,VN), (FP,VO), (FP,VP), (FP,VQ), (FP,VR), (FP,VS), (FP,VT), (FP,VU), (FP,VV), (FP,Vw), (FP,VX), (FP,VY), (FP,VZ), (FP,WA), (FP,WB), (FP,WC), (FQ,VA), (FQ,VB), (FQ,VC), (FQ,VD), (FQ,VE), (FQ,VF), (FQ,VG), (FQ, VH), (FQ,VI), (FQ,VJ), (FQ,VK), (FQ,VL), (FQ,VM), (FQ,VN), (FQ,VO), (FQ,VP), (FQ,VQ), (FQ,VR), (FQ, VS), (FQ,VT), (FQ,VU), (FQ,VV), (FQ,VW), (FQ,VX), (FQ,VY), (FQ,VZ), (FQ,WA), (FQ,WB), (FQ,WC), (FR, VA), (FR,VB), (FR,VC), (FR,VD), (FR,VE), (FR,VF), (FR,VG), (FR,VH), (FR,VI), (FR,VJ), (FR,VK), (FR,VL), (FR,VM), (FR,VN), (FR,VO), (FR,VP), (FR,VQ), (FR, VR), (FR,VS), (FR,VT), (FR,VU), (FR,VV), (FR,VW), (FR,VX), (FR,VY), (FR,VZ), (FR,WA), (FR,WB), (FR, WC), (FS,VA), (FS,VB), (FS,VC), (FS,VD), (FS,VE), (FS,VF), (FS,VG), (FS,VH), (FS,VI), (FS,VJ), (FS,VK), (FS,VL), (FS,VM), (FS,VN), (FS,VO), (FS,VP), (FS,VQ), (FS,VR), (FS,VS), (FS,VT), (FS,VU), (FS,VV), (FS,VW), (FS,VX), (FS,VY), (FS,VZ), (FS,WA), (FS,WB), (FS,WC), (FT,VA), (FT,VB), (FT,VC), (FT,VD), (FT,VE), (FT,VF), (FT,VG), (FT,VH), (FT,VI), (FT,VJ), (FT,VK), (FT,VL), (FT,VM), (FT,VN), (FT,VO), (FT,VP), (FT,VQ), (FT,VR), (FT,VS), (FT,VT), (FT,VU), (FT,VV), (FT,VW), (FT,VX), (FT,VY), (FT,VZ), (FT,WA), (FT,WB), (FT,WC), (FU,VA), (FU,VB), (FU,VC), (FU,VD), (FU, VE), (FU,VF), (FU,VG), (FU,VH), (FU,VI), (FU,VJ), (FU,VK), (FU,VL), (FU,VM), (FU,VN), (FU,VO), (FU, VP), (FU,VQ), (FU,VR), (FU,VS), (FU,VT), (FU,VU), (FU,VV), (FU,VW), (FU,VX), (FU,VY), (FU,VZ), (FU, WA), (FU,WB), (FU,WC), (FV,VA), (FV,VB), (FV,VC), (FV,VD), (FV,VE), (FV,VF), (FV,VG), (FV,VH), (FV,VI), (FV,VJ), (FV,VK), (FV,VL), (FV,VM), (FV,VN), (FV,VO), (FV,VP), (FV,VQ), (FV,VR), (FV,VS), (FV,VT), (FV,VU), (FV,VV), (FV,VW), (FV,VX), (FV,VY), (FV,VZ), (FV,WA), (FV,WB), (FV,WC), (FW,VA), (FW,VB), (FW, VC), (FW,VD), (FW,VE), (FW,VF), (FW,VG), (FW,VH), (FW,VI), (FW,VJ), (FW,VK), (FW,VL), (FW,VM), (FW, VN), (FW,VO), (FW,VP), (FW,VQ), (FW,VR), (FW,VS), (FW,VT), (FW,VU), (FW,VV), (FW,VW), (FW,VX), (FW, VY), (FW,VZ), (FW,WA), (FW,WB), (FW,WC), (FX,VA), (FX,VB), (FX,VC), (FX,VD), (FX,VE), (FX,VF), (FX, VG), (FX,VH), (FX,VI), (FX,VJ), (FX,VK), (FX,VL), (FX,VM), (FX,VN), (FX,VO), (FX,VP), (FX,VQ), (FX, VR), (FX,VS), (FX,VT), (FX,WU), (FX,VV), (FX,VW), (FX,VX), (FX,VY), (FX,VZ), (FX,WA), (FX,WB), (FX, WC), (FY,VA), (FY,VB), (FY,VC), (FY,VD), (FY,VE), (FY,VF), (FY,VG), (FY,VH), (FY,VI), (FY,VJ), (FY,VK), (FY,VL), (FY,VM), (FY,VN), (FY,VO), (FY,VP), (FY,VQ), (FY,VR), (FY,VS), (FY,VT), (FY,VU), (FY,VV), (FY,VW), (FY,VX), (FY,VY), (FY,VZ), (FY,WA), (FY,WB), (FY,WC), (FZ,VA), (FZ,VB), (FZ,VC), (FZ,VD), (FZ,VE), (FZ,VF), (FZ,VG), (FZ,VH), (FZ,VI), (FZ,VJ), (FZ,VK), (FZ,VL), (FZ,VM), (FZ,VN), (FZ,VO), (FZ,VP), (FZ,VQ), (FZ,VR), (FZ,VS), (FZ,VT), (FZ,VU), (FZ,VV), (FZ,VW), (FZ,VX), (FZ,VY), (FZ, VZ), (FZ,WA), (FZ,WB), (FZ,WC),
  • (GA,VA), (GA,VB), (GA,VC), (GA,VD), (GA,VE), (GA, VF), (GA,VG), (GA,VH), (GA,VI), (GA,VJ), (GA,VK), (GA,VL), (GA,VM), (GA,VN), (GA,VO), (GA,VP), (GA, VQ), (GA,VR), (GA,VS), (GA,VT), (GA,VU), (GA,VV), (GA,VW), (GA,VX), (GA,VY), (GA,VZ), (GA,WA), (GA,WB), (GA,WC), (GB,VA), (GB,VB), (GB,VC), (GB, VD), (GB,VE), (GB,VF), (GB,VG), (GB,VH), (GB,VI), (GB,VJ), (GB,VK), (GB,VL), (GB,VM), (GB,VN), (GB, VO), (GB,VP), (GB,VQ), (GB,VR), (GB,VS), (GB,VT), (GB,VU), (GB,VV), (GB,VW), (GB,VX), (GB,VY), (GB, VZ), (GB,WA), (GB,WB), (GB,WC), (GC,VA), (GC,VA), (GC,VB), (GC,VB), (GC,VC), (GC,VD), (GC,VE), (GC, VF), (GC,VG), (GC,VH), (GC,VI), (GC,VJ), (GC,VI), (GC,VL), (GC,VM), (GC,VN), (GC,VO), (GC,VP), (GC, VQ), (GC,VR), (GC,VS), (GC,VT), (GC,VU), (GC,VW), (GC,VW), (GC,VX), (GC,VY), (GC,VZ), (GC,WA), (GC, WB), (GC,WC), (GD,VC), (GD,VD), (GD,VE), (GD,VF), (GD,VG), (GD,VH), (GD,VI), (GD,VJ), (GD,VK), (GD, VL), (GD,VM), (GD,VN), (GD,VO), (GD,VP), (GD,VQ), (GD,VR), (GD,VS), (GD,VT), (GD,VU), (GD,VV), (GD, VW), (GD,VX), (GD,VY), (GD,VZ), (GD,WA), (GD,WB), (GD,WC), (GE,VA), (GE,VB), (GE,VC), (GE, VD), (GE,VE), (GE,VF), (GE,VG), (GE,VH), (GE,VI), (GE,VJ), (GE,VK), (GE,VL), (GE,VM), (GE,VN), (GE, VO), (GE,VP), (GE,VQ), (GE,VR), (GE,VS), (GE,VT), (GE,VU), (GE,VV), (GE,VW), (GE,VX), (GE,VY), (GE, VZ), (GE,WA), (GE,WB), (GE,WC), (GF,VA), (GF,VB), (GF,VC), (GF,VD), (GF,VE), (GF,VF), (GF,VG), (GF,VH), (GF,VI), (GF,VJ), (GF,VK), (GF,VL), (GF,VM), (GF,VN), (GF,VO), (GF,VP), (GF,VQ), (GF,VR), (GF,VS), (GF,VT), (GF,VU), (GF,VV), (GF,VW), (GF, VX), (GF,VY), (GF,VZ), (GF,WA), (GF,WB), (GF,WC), (GG,VA), (GG,VB), (GG,VC), (GG,VD), (GG,VE), (GG, VF), (GG,VG), (GG,VH), (GG,VI), (GG,VJ), (GG,VK), (GG,VL), (GG,VM), (GG,VN), (GG,VO), (GG,VP), (GG, VQ), (GG,VR), (GG,VS), (GG,VT), (GG,VU), (GG,VV), (GG,VW), (GG,VX), (GG,VY), (GG,VZ), (GG,WA), (GG,WB), (GG,WC), (GH,VA), (GH,VB), (GH,VC), (GH,VD), (GH,VE), (GH,VF), (GH,VG), (GH,VH), (GH, VI), (GH,VJ), (GH,VK), (GH,VL), (GH,VM), (GH,VN), (GH,VO), (GH,VP), (GH,VQ), (GH,VR), (GH,VS), (GH, VT), (GH,VU), (GH,VW), (GH,VW), (GH, VX), (GH,VY), (GH,VZ), (GH,WA), (GH,WB), (GH,WC), (GI, VA), (GI,VB), (GI,VC), (GI,VD), (GI,VE), (GI,VF), (GI, VG), (GI,VH), (GI,VI), (GI,VJ), (GI,VK), (GI,VL), (GI, VM), (GI,VN), (GI,VO), (GI,VP), (GI,VQ), (GI,VR), (GI, VS), (GI,VT), (GI,VU), (GI,VV), (GI,VW), (GI,VX), (GI, VY), (GI,VZ), (GI,WA), (GI,WB), (GI,WC), (GJ,VA), (GJ,VB), (GJ,VC), (GJ,VD), (GJ,VE), (GJ,VF), (GJ,VG), (GJ,VH), (GJ,VI), (GJ,VJ), (GJ,VK), (GJ,VL), (GJ,VM), (GJ,VN), (GJ,VO), (GJ,VP), (GJ,VQ), (GJ,VR), (GJ,VS), (GJ,VT), (GJ,VU), (GJ,VV), (GJ,VW), (GJ,VX), (GJ,VY), (GJ,VZ), (GJ,WA), (GJ,WB), (GJ,WC), (GK, VA), (GK,VB), (GK,VC), (GK,VD), (GK,VE), (GK,VF), (GK,VG), (GK,VH), (GK,VI), (GK,VJ), (GK,VK), (GK, VL), (GK,VM), (GK,VN), (GK,VO), (GK,VP), (GN,VQ), (GK,VR), (GK,VS), (GK,VT), (GK,VU), (GK,VV), (GK, VW), (GK,VX), (GK,VY), (GK,VZ), (GK,WA), (GK,WB), (GK,WC), (GL,VA), (GL,VB), (GL,VC), (GL, VD), (GL,VE), (GL,VF), (GL,VG), (GL,VH), (GL,VI), (GL,VJ), (GL,VK), (GL,VL), (GL,VM), (GL,VN), (GL, VO), (GL,VP), (GL,VQ), (GL,VR), (GL,VS), (GL,VT), (GL,VU), (GL,VV), (GL,VW), (GL,VX), (GL,VY), (GL, VZ), (GL,WA), (GL,WB), (GL,WC), (GM,VA), (GM,VB), (GM,VC), (GM,VD), (GM,VE), (GM,VF), (GM,VG), (GM,VH), (GM,VI), (GM,VJ), (GM,VK), (GM,VL), (GM,VM), (GM,VN), (GM,VO), (GM,VP), (GM,VQ), (GM,VR), (GM,VS), (GM,VT), (GM,VU), (GM,VV), (GM,VW), (GM,VX), (GM,VY), (GM,VZ), (GM,WA), (GM,WB), (GM,WC), (GN,VA), (GN,VB), (GN,VC), (GN,VD), (GN,VE), (GN,VF), (GN,VG), (GN, VH), (GN,VI), (GN,VJ), (GN,VK), (GN,VL), (GN,VM), (GN,VN), (GN,VO), (GN,VP), (GN,VQ), (GN,VR), (GN, VS), (GN,VT), (GN,VU), (GN,VV), (GN,VW), (GN,VX), (GN,VY), (GN,VZ), (GN,WA), (GN,WB), (GN,WC), (GO,VA), (GO,VB), (GO,VC), (GO,VD), (GO,VE), (GO, VF), (GO,VG), (GO,VH), (GO,VI), (GO,VJ), (GO,VK), (GO,VL), (GO,VM), (GO,VN), (GO,VO), (GO,VP), (GO, VQ), (GO,VR), (GO,VS), (GO,VT), (GO,VU), (GO,VV), (GO,VW), (GO,VX), (GO,VY), (GO,VZ), (GO,WA), (GO,WB), (GO,WC), (GP,VA), (GP,VB), (GP,VC), (GP, VD), (GP,VE), (GP,VF), (GP,VG), (GP,VH), (GP,VI), (GP, VJ), (GP,VK), (GP,VL), (GP,VM), (GP,VN), (GP,VO), (GP,VP), (GP,VQ), (GP,VR), (GP,VS), (GP,VT), (GP,VU), (GP,UV), (GP,VW), (GP,VX), (GP,VY), (GP,VZ), (GP,WA), (GP,WB), (GP,WC), (GQ,VA), (GQ,VB), (GQ, VC), (GQ,VD), (GQ,VE), (GQ,VF), (GQ,VG), (GQ,VH), (GQ,VI), (GQ,VJ), (GQ,VK), (GQ,VL), (GQ,VM), (GQ, VN), (GQ,VO), (GQ,VP), (GQ,VQ), (GQ,VR), (GQ,VS), (GQ,VT), (GQ,VU), (GQ,VV), (GQ,VW), (GQ, VX), (GQ,VY), (GQ,VZ), (GQ,WA), (GQ,WB), (GQ,WC), (GR,VA), (GR,VB), (GR,VC), (GR,VD), (GR,VE), (GR, VF), (GR,VG), (GR,VH), (GR,VI), (GR,VJ), (GR,VK), (GR,VL), (GR,VM), (GR,VN), (GR,VO), (GR,VP), (GR, VQ), (GR,VR), (GR,VS), (GR,VT), (GR,VU), (GR,VV), (GR,VW), (GR,VX), (GR,VY), (GR,VZ), (GR,WA), (GR, WB), (GR,WC), (GS,VA), (GS,VB), (GS,VC), (GS,VD), (GS,VE), (GS,VF), (GS,VG), (GS,VH), (GS,VI), (GS,VJ), (GS,VK), (GS,VL), (GS,VM), (GS,VN), (GS, VO), (GS,VP), (GS,VQ), (GS,VR), (GS,VS), (GS,VT), (GS,VU), (GS,VV), (GS,VW), (GS,VX), (GS,VY), (GS, VZ), (GS,WA), (GS,WB), (GS,WC), (GT,VA), (GT,VB), (GT,VC), (GT,VD), (GT,VE), (GT,VF), (GT,VG), (GT, VH), (GT,VI), (GT,VJ), (GT,VK), (GT,VL), (GT,VM), (GT,VN), (GT,VO), (GT,VP), (GT,VQ), (GT,VR), (GT, VS), (GT,VT), (GT,VU), (GT,VV), (GT,VW), (GT,VX), (GT,VY), (GT,VZ), (GT,WA), (GT,WB), (GT,WC), (GU, VA), (GU,VB), (GU,VC), (GU,VD), (GU,VE), (GU,VF), (GU,VG), (GU,VH), (GU,VI), (GU,VJ), (GU,VK), (GU, VL), (GU,VM), (GU,VN), (GU,VO), (GU,VP), (GU,VQ), (GU,VR), (GU,VS), (GU,VT), (GU,VU), (GU,VV), (GU, VW), (GU,VX), (GU,VY), (GU,VZ), (GU,WA), (GU,WB), (GU,WC), (GV,VA), (GV,VB), (GV,VC), (GV, VD), (GV,VE), (GV,VF), (GV,VG), (GV,VH), (GV,VI), (GV,VJ), (GV,VK), (GV,VL), (GV,VM), (GV,VN), (GV, VO), (GV,VP), (GV,VQ), (GV,VR), (GV,VS), (GV,VT), (GV,VU), (GV,VV), (GV,VW), (GV,VX), (GV,VY), (GV, VZ), (GV,WA), (GV,WB), (GV,WC), (GW,VA), (GW,VB), (GW,VC), (GW,VD), (GW,VE), (GW,VF), (GW,VG), (GW,VH), (GW,VI), (GW,VJ), (GW,VK), (GW,VL), (GW,VM), (GW,VN), (GW,VO), (GW,VP), (GW,VQ), (GW,VR), (GW,VS), (GW,VT), (GW,VU), (GW,VV), (GW,VW), (GW,VX), (GW,VY), (GW,VZ), (GW,WA), (GW,WB), (GW,WC), (GX,VA), (GX,VB), (GX,VC), (GX,VD), (GX,VE), (GX,VF), (GX,VG), (GX, VH), (GX,VI), (GX,VJ), (GX,VK), (GX,VL), (GX,VM), (GX,VN), (GX,VO), (GX,VP), (GX,VQ), (GX,VR), (GX, VS), (GX,VT), (GX,VU), (GX,VV), (GX,VW), (GX,VX), (GX,VY), (GX,VZ), (GX,WA), (GX,WB), (GX,WC), (GY,VA), (GY,VB), (GY,VC), (GY,VD), (GY,VE), (GY, VF), (GY,VG), (GY,VH), (GY,VI), (GY,VJ), (GY,VK), (GY,VL), (GY,VM), (GY,VN), (GY,VO), (GY,VP), (GY, VQ), (GY,VR), (GY,VS), (GY,VT), (GY,VU), (GY,VV), (GY,VW), (GY,VX), (GY,VY), (GY,VZ), (GY,WA), (GY, WB), (GY,WC), (GZ,VA), (GZ,VB), (GZ,VC), (GZ,VD), (GZ,VE), (GZ,VF), (GZ,VG), (GZ,VH), (GZ,VI), (GZ, VJ), (GZ,VK), (GZ,VL), (GZ,VM), (GZ,VN), (GZ,VO), (GZ,VP), (GZ,VQ), (GZ,VR), (GZ,VS), (GZ,VT), (GZ, VU), (GZ,VV), (GZ,VW), (GZ,VX), (GZ,VY), (GZ,VZ), (GZ,WA), (GZ,WB), (GZ,WC),
  • (HA,VA), (HA,VB), (HA,VC), (HA,VD), (HA,VE), (HA, VF), (HA,VG), (HA,VH), (HA,VI), (HA,VJ), (HA,VK), (HA,VL), (HA,VM), (HA,VN), (HA,VO), (HA,VP), (HA, VQ), (HA,VR), (HA,VS), (HA,VT), (HA,VU), (HA,VV), (HA,VW), (HA,VX), (HA,VY), (HA,VZ), (HA,WA), (HA,WB), (HA,WC), (HB,VA), (HB,VB), (HB,VC), (HB, VD), (HB,VE), (HB,VF), (HB,VG), (HB,VH), (HB,VI), (HB,VJ), (HB,VK), (HB,VL), (HB,VM), (HB,VN), (HB, VO), (HB,VP), (HB,VQ), (HB,VR), (HB,VS), (HB,VT), (HB,VU), (HB,VV), (HB,VW), (HB,VX), (HB,VY), (HB, VZ), (HB,WA), (HB,WB), (HB,WC), (HC,VA), (HC,VA), (HC,VB), (HC,VB), (HC,VC), (HC,VD), (HC,VE), (HC, VF), (HC,VG), (HC,VH), (HC,VI), (HC,VJ), (HC,VK), (HC,VL), (HC,VM), (HC,VN), (HC,VO), (HC,VP), (HC, VQ), (HC,VR), (HC,VS), (HC,VT), (HC,WU), (HC,VV), (HC,VW), (HC,VX), (HC,VY), (HC,VZ), (HC,WA), (HC, WB), (HC,WC), (HD,VC), (HD,VD), (HD,VE), (HD,VF), (HD,VG), (HD,VH), (HD,VI), (HD,VJ), (HD,VK), (HD, VL), (HD,VM), (HD,VN), (HD,VO), (HD,VP), (HD,VQ), (HD,VR), (HD,VS), (HD,VT), (HD,VU), (HD,VV), (HD, VW), (HD,VX), (HD,VY), (HD,VZ), (HD,WA), (HD,WB), (HD,WC), (HE,VA), (HE,VB), (HE,VC), (HE, VD), (HE,VE), (HE,VF), (HE,VG), (HE,VH), (HE,VI), (HE,VJ), (HE,VK), (HE,VL), (HE,VM), (HE,VN), (HE, VO), (HE,VP), (HE,VQ), (HE,VR), (HE,VS), (HE,VT), (HE,VU), (HE,VV), (HE,VW), (HE,VX), (HE,VY), (HE, VZ), (HE,WA), (HE,WB), (HE,WC), (HF,VA), (HF,VB), (HF,VC), (HF,VD), (HF,VE), (HF,VF), (HF,VG), (HF,VH), (HF,VI), (HF,VJ), (HF,VK), (HF,VL), (HF,VM), (HF,VN), (HF,VO), (HF,VP), (HF,VQ), (HF,VR), (HF,VS), (HF,VT), (HF,VU), (HF,VV), (HF,VW), (HF, VX), (HF,VY), (HF,VZ), (HF,WA), (HF,WB), (HF,WC), (HG,VA), (HG,VB), (HG,VC), (HG,VD), (HG,VE), (HG, VF), (HG,VG), (HG,VH), (HG,VI), (HG,VJ), (HG,VK), (HG,VL), (HG,VM), (HG,VN), (HG,VO), (HG,VP), (HG, VQ), (HG,VR), (HG,VS), (HG,VT), (HG,VU), (HG,VV), (HG,VW), (HG,VX), (HG,VY), (HG,VZ), (HG,WA), (HG,WB), (HG,WC), (HH,VA), (HH,VB), (HH,VC), (HH,VD), (HH,VE), (HH,VF), (HH,VG), (HH,VH), (HH, VI), (HH,VJ), (HH,VK), (HH,VL), (HH,VM), (HH,VN), (HH,VO), (HH,VP), (HH,VQ), (HH,VR), (HH,VS), (HH, VT), (HH,VU), (HH,VV), (HH,VW), (HH,VX), (HH,VY), (HH,VZ), (HH,WA), (HH,WB), (HH,WC), (HI, VA), (HI,VB), (HI,VC), (HI,VD), (HI,VE), (HI,VF), (HI, VG), (HI,VH), (HI,VI), (HI,VJ), (HI,VK), (HI,VL), (HI, VM), (HI,VN), (HI,VO), (HI,VP), (HI,VQ), (HI,VR), (HI, VS), (HI,VT), (HI,VU), (HI,VV), (HI,VW), (HI,VX), (HI, VY), (HI,VZ), (HI,WA), (HI,WB), (HI,WC), (HJ,VA), (HJ,VB), (HJ,VC), (HJ,VD), (HJ,VE), (HJ,VF), (HJ,VG), (HJ,VH), (HJ,VI), (HJ,VJ), (HJ,VK), (HJ,VL), (HJ,VM), (HJ,VN), (HJ,VO), (HJ,VP), (HJ,VQ), (HJ,VR), (HJ,VS), (HJ,VT), (HJ,VU), (HJ,VV), (HJ,VW), (HJ,VX), (HJ,VY), (HJ,VZ), (HJ,WA), (HJ,WB), (HJ,WC), (HK, VA), (HK,VB), (HK,VC), (HK,VD), (HK,VE), (HK,VF), (HK,VG), (HK,VH), (HK,VI), (HK,VJ), (HK,VK), (HK, VL), (HK,VM), (HK,VN), (HK,VO), (HK,VP), (HK,VQ), (HK,VR), (HK,VS), (HK,VT), (HK,VU), (HK,VV), (HK, VW), (HK,VX), (HK,VY), (HK,VZ), (HK,WA), (HK,WB), (HK,WC), (HL,VA), (HL,VB), (HL,VC), (HL, VD), (HL,VE), (HL,VF), (HL,VG), (HL,VH), (HL,VI), (HL,VJ), (HL,VK), (HL,VL), (HL,VM), (HL,VN), (HL, VO), (HL,VP), (HL,VQ), (HL,VR), (HL,VS), (HL,VT), (HL,VU), (HL,VV), (HL,VW), (HL,VX), (HL,VY), (HL, VZ), (HL,WA), (HL,WB), (HL,WC), (HM,VA), (HM,VB), (HM,VC), (HM,VD), (HM,VE), (HM,VF), (HM,VG), (HM,VH), (HM,VI), (HM,VJ), (HM,VK), (HM,VL), (HM,VM), (HM,VN), (HM,VO), (HM,VP), (HM,VQ), (HM,VR), (HM,VS), (HM,VT), (HM,VU), (HM,VV), (HM,VW), (HM,VX), (HM,VY), (HM,VZ), (HM,WA), (HM,WB), (HM,WC), (HN,VA), (HN,VB), (HN,VC), (HN,VD), (HN,VE), (HN,VF), (HN,VG), (HN, VH), (HN,VI), (HN,VJ), (HN,VK), (HN,VL), (HN,VM), (HN,VN), (HN,VO), (HN,VP), (HN,VQ), (HN,VR), (HN, VS), (HN,VT), (HN,VU), (HN,VV), (HN,VW), (HN,VX), (HN,VY), (HN,VZ), (HN,WA), (HN,WB), (HN,WC), (HO,VA), (HO,VB), (HO,VC), (HO,VD), (HO,VE), (HO, VF), (HO,VG), (HO,VH), (HO,VI), (HO,VJ), (HO,VK), (HO,VL), (HO,VM), (HO,VN), (HO,VO), (HO,VP), (HO, VQ), (HO,VR), (HO,VS), (HO,VT), (HO,VU), (HO,VV), (HO,VW), (HO,VX), (HO,VY), (HO,VZ), (HO,WA), (HO,WB), (HO,WC), (HP,VA), (HP,VB), (HP,VC), (HP, VD), (HP,VE), (HP,VF), (HP,VG), (HP,VH), (HP,VI), (HP, VJ), (HP,VK), (HP,VL), (HP,VM), (HP,VN), (HP,VO), (HP,VP), (HP,VQ), (HP,VR), (HP,VS), (HP,VT), (HP,VU), (HP,VV), (HP,VW), (HP,VX), (HP,VY), (HP,VZ), (HP,WA), (HP,WB), (HP,WC), (HQ,VA), (HQ,VB), (HQ, VC), (HQ,VD), (HQ,VE), (HQ,VF), (HQ,VG), (HQ,VH), (HQ,VI), (HQ,VJ), (HQ,VK), (HQ,VL), (HQ,VM), (HQ, VN), (HQ,VO), (HQ,VP), (HQ,VQ), (HQ,VR), (HQ,VS), (HQ,VT), (HQ,VU), (HQ,VV), (HQ,VW), (HQ,VX), (HQ,VY), (HQ,VZ), (HQ,WA), (HQ,WB), (HQ,WC), (HR,VA), (HR,VB), (HR,VC), (HR,VD), (HR,VE), (HR, VF), (HR,VG), (HR,VH), (HR,VI), (HR,VJ), (HR,VK), (HR,VL), (HR,VM), (HR,VN), (HR,VO), (HR,VP), (HR, VQ), (HR,VR), (HR,VS), (HR,VT), (HR,VU), (HR,VV), (HR,VW), (HR,VX), (HR,VY), (HR,VZ), (HR,WA), (HR, WB), (HR,WC), (HS,VA), (HS,VB), (HS,VC), (HS,VD), (HS,VE), (HS,VF), (HS,VG), (HS,VH), (HS,VI), (HS,VJ), (HS,VK), (HS,VL), (HS,VM), (HS,VN), (HS, VO), (HS,VP), (HS,VQ), (HS,VR), (HS,VS), (HS,VT), (HS,VU), (HS,VV), (HS,VW), (HS,VX), (HS,VY), (HS, VZ), (HS,WA), (HS,WB), (HS,WC), (HT,VA), (HT,VB), (HT,VC), (HT,VD), (HT,VE), (HT,VF), (HT,VG), (HT, VH), (HT,VI), (HT,VJ), (HT,VK), (HT,VL), (HT,VM), (HT,VN), (HT,VO), (HT,VP), (HT,VQ), (HT,VR), (HT, VS), (HT,VT), (HT,VU), (HT,VV), (HT,VW), (HT,VX), (HT,VY), (HT,VZ), (HT,WA), (HT,WB), (HT,WC), (HU, VA), (HU,VB), (HU,VC), (HU,VD), (HU,VE), (HU,VF), (HU,VG), (HU,VH), (HU,VI), (HU,VJ), (HU,VK), (HU, VL), (HU,VM), (HU,VN), (HU,VO), (HU,VP), (HU,VQ), (HU,VR), (HU,VS), (HU,VT), (HU,VU), (HU,VV), (HU, VW), (HU,VX), (HU,VY), (HU,VZ), (HU,WA), (HU,WB), (HU,WC), (HV,VA), (HV,VB), (HV,VC), (HV, VD), (HV,VE), (HV,VF), (HV,VG), (HV,VH), (HV,VI), (HV,VJ), (HV,VK), (HV,VL), (HV,VM), (HV,VN), (HV, VO), (HV,VP), (HV,VQ), (HV,VR), (HV,VS), (HV,VT), (HV,VU), (HV,VV), (HV,VW), (HV,VX), (HV,VY), (HV, VZ), (HV,WA), (HV,WB), (HV,WC), (HW,VA), (HW,VB), (HW,VC), (HW,VD), (HW,VE), (HW,VF), (HW,VG), (HW,VH), (HW,VI), (HW,VJ), (HW,VK), (HW,VL), (HW,VM), (HW,VN), (HW,VO), (HW,VP), (HW,VQ), (HW,VR), (HW,VS), (HW,VT), (HW,VU), (HW,VV), (HW,VW), (HW,VX), (HW,VY), (HW,VZ), (HW,WA), (HW,WB), (HW,WC), (HX,VA), (HX,VB), (HX,VC), (HX,VD), (HX,VE), (HX,VF), (HX,VG), (HX, VH), (HX,VI), (HX,VJ), (HX,VK), (HX,VL), (HX,VM), (HX,VN), (HX,VO), (HX,VP), (HX,VQ), (HX,VR), (HX, VS), (HX,VT), (HX,VU), (HX,VV), (HX,VW), (HX,VX), (HX,VY), (HX,VZ), (HX,WA), (HX,WB), (HX,WC), (HY,VA), (HY,VB), (HY,VC), (HCVD), (HY,VE), (HY, VF), (HY,VG), (HY,VH), (HY,VI), (HY,VJ), (HY,VK), (HY,VL), (HY,VM), (HY,VN), (HY,VO), (HY,VP), (HY, VQ), (HY,VR), (HY,VS), (HY,VT), (HY,VU), (HY,VV), (HY,VW), (HY,VX), (HY,VY), (HY,VZ), (HY,WA), (HY, WB), (HY,WC), (HZ,VA), (HZ,VB), (HZ,VC), (HZ,VD), (HZ,VE), (HZ,VF), (HZ,VG), (HZ,VH), (HZ,VI), (HZ, VJ), (HZ,VK), (HZ,VL), (HZ,VM), (HZ,VN), (HZ,VO), (HZ,VP), (HZ,VQ), (HZ,VR), (HZ,VS), (HZ,VT), (HZ, VU), (HZ,VV), (HZ,VW), (HZ,VX), (HZ,VY), (HZ,VZ), (HZ,WA), (HZ,WB), (HZ,WC),
  • (IA,VA), (IA,VB), (IA,VC), (IA,VD), (IA,VE), (IA,VF), (IA, VG), (IA,VH), (IA,VI), (IA,VJ), (IA,VK), (IA,VL), (IA, VM), (IA,VN), (IA,VO), (IA,VP), (IA,VQ), (IA,VR), (IA, VS), (IA,VT), (IA,VU), (IA,VV), (IA,VW), (IA,VX), (IA, VY), (IA,VZ), (IA,WA), (IA,WB), (IA,WC), (IB,VA), (IB, VB), (IB,VC), (IB,VD), (IB,VE), (IB,VF), (IB,VG), (IB, VH), (IB,VI), (IB,VJ), (IB,VK), (IB,VL), (IB,VM), (IB, VN), (IB,VO), (IB,VP), (IB,VQ), (IB,VR), (IB,VS), (IB, VT), (IB,VU), (IB,VV), (IB,VW), (IB,VX), (IB,VY), (IB, VZ), (IB,WA), (IB,WB), (IB,WC), (IC,VA), (IC,VA), (IC, VB), (IC,VB), (IC,VC), (IC,VD), (IC,VE), (IC,VF), (IC, VG), (IC,VH), (IC,VI), (IC,VJ), (IC,VK), (IC,VL), (IC, VM), (IC,VN), (IC,VO), (IC,VP), (IC,VQ), (IC,VR), (IC, VS), (IC,VT), (IC,VU), (IC,VV), (IC,VW), (IC,VX), (IC, VY), (IC,VZ), (IC,WA), (IC,WB), (IC,WC), (ID,VC), (ID, VD), (ID,VE), (ID,VF), (ID,VG), (ID,VH), (ID,VI), (ID, VJ), (ID,VK), (ID,VL), (ID,VM), (ID,VN), (ID,VO), (ID, VP), (ID,VQ), (ID,VR), (ID,VS), (ID,VT), (ID,VU), (ID, VV), (ID,VW), (ID,VX), (ID,VY), (ID,VZ), (ID,WA), (ID,WB), (ID,WC), (IE,VA), (IE,VB), (IE,VC), (IE,VD), (IE,VE), (IE,VF), (IE,VG), (IE,VH), (IE,VI), (IE,VJ), (IE, VK), (IE,VL), (IE,VM), (IE,VN), (IE,VO), (IE,VP), (IE, VQ), (IE,VR), (IE,VS), (IE,VT), (IE,VU), (IE,VV), (IE, VW), (IE,VX), (IE,VY), (IE,VZ), (IE,WA), (IE,WB), (IE, WC), (IF,VA), (IF,VB), (IF,VC), (IF,VD), (IF,VE), (IF, VF), (IF,VG), (IF,VH), (IF,VI), (IF,VJ), (IF,VK), (IF,VL), (IF,VM), (IF,VN), (IF,VO), (IF,VP), (IF,VQ), (IF,VR), (IF, VS), (IF,VT), (IF,VU), (IF,VV), (IF,VW), (IF,VX), (IF, VY), (IF,VZ), (IF,WA), (IF,WB), (IF,WC), (IG,VA), (IG, VB), (IG,VC), (IG,VD), (IG,VE), (IG,VF), (IG,VG), (IG, VH), (IG,VI), (IG,VJ), (IG,VK), (IG,VL), (IG,VM), (IG, VN), (IG,VO), (IG,VP), (IG,VQ), (IG,VR), (IG,VS), (IG, VT), (IG,VU), (IG,VV), (IG,VW), (IG,VX), (IG,VY), (IG, VZ), (IG,WA), (IG,WB), (IG,WC), (IH,VA), (IH,VB), (IH,VC), (IH,VD), (IH,VE), (IH,VF), (IH,VG), (IH,VH), (IH,VI), (IH,VJ), (IH,VK), (IH,VL), (IH,VM), (IH,VN), (IH,VO), (IH,VP), (IH,VQ), (IH,VR), (IH,VS), (IH,VT), (IH,VU), (IH,VV), (IH,VW), (IH,VX), (IH,VY), (IH,VZ), (IH,WA), (IH,WB), (IH,WC), (II,VA), (II,VB), (II,VC), (II,VD), (II,VE), (II,VF), (II,VG), (II,VH), (II,VI), (II,VJ), (II,VK), (II,VL), (II,VM), (II,VN), (,VO), (II,VP), (II, VQ), (II,VR), (II,VS), (II,VT), (II,VU), (II,VV), (II,VW), (II,VX), (II,VY), (II,VZ), (II,WA), (II,WB), (II,WC), (II, VA), (IJ,VB), (IJ,VC), (IJ,VD), (IJ,VE), (IJ,VF), (IJ,VG), (IJ,VH), (IJ,VI), (IJ,VJ), (IJ,VK), (IJ,VL), (IJ,VM), (IJ, VN), (IJ,VO), (IJ,VP), (IJ,VQ), (IJ,VR), (IJ,VS), (IJ,VT), (IJ,VU), (IJ,VV), (IJ,VW), (IJ,VX), (IJ,VY), (IJ,VZ), (IJ, WA), (IJ,WB), (IJ,WC), (IK,VA), (IK,VB), (IK,VC), (IK, VD), (IK,VE), (IK,VF), (IK,VG), (IK,VH), (IK,VI), (IK, VJ), (IK,VK), (IK,VL), (IK,VM), (IK,VN), (IK,VO), (IK, VP), (IK,VQ), (IK,VR), (IK,VS), (IK,VT), (IK,VU), (IK, VV), (IK,VW), (IK,VX), (IK,VY), (IK,VZ), (IK,WA), (IK,WB), (IK,WC), (IL,VA), (IL,VB), (IL,VC), (IL,VD), (IL,VE), (IL,VF), (IL,VG), (IL,VH), (IL,VI), (IL,VJ), (IL, VK), (IL,VL), (IL,VM), (IL,VN), (IL,VO), (IL,VP), (IL, VQ), (IL,VR), (IL,VS), (IL,VT), (IL,VU), (IL,VW), (IL, VW), (IL,VX), (IL,VY), (IL,VZ), (IL,WA), (IL,WB), (IL, WC), (IM,VA), (IM,VB), (IM,VC), (IM,VD), (IM,VE), (IM,VF), (IM,VG), (IM,VH), (IM,VI), (IM,VJ), (IM,VK), (IM,VL), (IM,VM), (IM,VN), (IM,VO), (IM,VP), (IM, VQ), (IM,VR), (IM,VS), (IM,VT), (IM,VU), (IM,VV), (IM,VW), (IM,VX), (IM,VY), (IM,VZ), (IM,WA), (IM, WB), (IM,WC), (IN,VA), (IN,VB), (IN,VC), (IN,VD), (IN,VE), (IN,VF), (IN,VG), (IN,VH), (IN,VI), (IN,VJ), (IN,VK), (IN,VL), (IN,VM), (IN,VN), (IN,VO), (IN,VP), (IN,VQ), (IN,VR), (IN,VS), (IN,VT), (IN,VU), (IN,VV), (IN,VW), (IN,VX), (IN,VY), (IN,VZ), (IN,WA), (IN,WB), (IN,WC), (IO,VA), (IO,VB), (IO,VC), (IO,VD), (IO,VE), (IO,VF), (IO,VG), (IO,VH), (IO,VI), (IO,VJ), (IO,VK), (IO,VL), (IO,VM), (IO,VN), (IO,VO), (IO,VP), (IO,VQ), (IO,VR), (IO,VS), (IO,VT), (IO,VU), (IO,VV), (IO,VW), (IO,VX), (O,VY), (IO,VZ), (IO,WA), (IO,WB), (IO,WC), (IP,VA), (IP,VB), (IP,VC), (IP,VD), (IP,VE), (IP,VF), (IP,VG), (IP,VH), (IP,VI), (IP,VJ), (IP, VK), (IP,VL), (IP,VM), (IP,VN), (IP,VO), (IP,VP), (IP,VQ), (IP,VR), (IP,VS), (IP,VT), (IP,VU), (IP,VV), (IP, VW), (IP,VX), (IP,VY), (IP,VZ), (IP,WA), (IP,WB), (IP, WC), (IQ,VA), (IQ,VB), (IQ,VC), (IQ,VD), (IQ,VE), (IQ, VF), (IQ,VG), (IQ,VH), (IQ,VI), (IQ,VJ), (IQ,VK), (IQ, VL), (IQ,VM), (IQ,VN), (IQ,VO), (IQ,VP), (IQ,VQ), (IQ, VR), (IQ,VS), (IQ,VT), (IQ,VU), (IQ,VV), (IQ,VW), (IQ, VX), (IQ,VY), (IQ,VZ), (IQ,WA), (IQ,WB), (IQ,WC), (IR,VA), (IR,VB), (IR,VC), (IR,VD), (IR,VE), (IR,VF), (IR,VG), (IR,VH), (IR,VI), (IR,VJ), (IR,VK), (IR,VL), (IR,VM), (IR,VN), (IR,VO), (IR,VP), (IR,VQ), (IR,VR), (IR,VS), (IR,VT), (IR,VU), (IR,VV), (IR,VW), (IR,VX), (IR,VY), (IR,VZ), (IR,WA), (IR,WB), (IR,WC), (IS,VA), (IS,VB), (IS,VC), (IS,VD), (IS,VE), (IS,VF), (IS,VG), (IS, VH), (IS,VI), (IS,VJ), (IS,VK), (IS,VL), (IS,VM), (IS, VN), (IS,VO), (IS,VP), (IS,VQ), (IS,VR), (IS,VS), (IS, VT), (IS,VU), (IS,VW), (IS,VW), (IS,VX), (IS,VY), (IS, VZ), (IS,WA), (IS,WB), (IS,WC), (IT,VA), (IT,VB), (IT, VC), (IT,VD), (IT,VE), (IT,VF), (IT,VG), (IT,VH), (IT, VI), (IT,VJ