USRE43298E1 - Peptides as NS3-serine protease inhibitors of hepatitis C virus - Google Patents

Info

Publication number

USRE43298E1

USRE43298E1 US13/068,159 US201113068159A USRE43298E US RE43298 E1 USRE43298 E1 US RE43298E1 US 201113068159 A US201113068159 A US 201113068159A US RE43298 E USRE43298 E US RE43298E

Authority

US

United States

Prior art keywords

compound

mmol

shown below

hcv

interferon

Prior art date

2000-07-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Active, expires 2024-10-10

Links

• USPTO
• USPTO PatentCenter
• USPTO Assignment
• Espacenet
• Global Dossier
• Discuss

• 241000711549 Hepacivirus C Species 0.000 title claims description 148
• 102000004196 processed proteins & peptides Human genes 0.000 title description 8
• 108090000765 processed proteins & peptides Proteins 0.000 title description 8
• 239000003001 serine protease inhibitor Substances 0.000 title description 4
• 150000001875 compounds Chemical class 0.000 claims abstract description 440
• 108091005771 Peptidases Proteins 0.000 claims abstract description 60
• 239000004365 Protease Substances 0.000 claims abstract description 60
• 230000002401 inhibitory effect Effects 0.000 claims abstract description 52
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 47
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• 239000000203 mixture Substances 0.000 claims description 129
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• -1 enantiomers Chemical class 0.000 claims description 53
• 239000011780 sodium chloride Substances 0.000 claims description 47
• 102000014150 Interferons Human genes 0.000 claims description 43
• 108010050904 Interferons Proteins 0.000 claims description 43
• 229940079322 interferon Drugs 0.000 claims description 43
• 150000003839 salts Chemical class 0.000 claims description 34
• 239000012453 solvate Substances 0.000 claims description 29
• 108010047761 Interferon-alpha Proteins 0.000 claims description 15
• 102000006992 Interferon-alpha Human genes 0.000 claims description 15
• 229920001184 polypeptide Polymers 0.000 claims description 14
• 239000004480 active ingredient Substances 0.000 claims description 13
• 208000005176 Hepatitis C Diseases 0.000 claims description 11
• 230000000694 effects Effects 0.000 claims description 9
• 230000000051 modifying Effects 0.000 claims description 9
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