USRE39651E1 - Apparatus for rapid cooling of the brain and method of performing same - Google Patents
Apparatus for rapid cooling of the brain and method of performing same Download PDFInfo
- Publication number
- USRE39651E1 USRE39651E1 US09/895,623 US89562301A USRE39651E US RE39651 E1 USRE39651 E1 US RE39651E1 US 89562301 A US89562301 A US 89562301A US RE39651 E USRE39651 E US RE39651E
- Authority
- US
- United States
- Prior art keywords
- bladder
- patient
- brain
- coolant
- tube
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000004556 brain Anatomy 0.000 title claims abstract description 31
- 238000001816 cooling Methods 0.000 title claims abstract description 17
- 238000000034 method Methods 0.000 title claims abstract description 16
- 239000002826 coolant Substances 0.000 claims abstract description 28
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 17
- 210000000214 mouth Anatomy 0.000 claims abstract description 16
- 210000003437 trachea Anatomy 0.000 claims abstract description 7
- 239000008280 blood Substances 0.000 claims abstract description 5
- 210000004369 blood Anatomy 0.000 claims abstract description 5
- 239000004744 fabric Substances 0.000 claims abstract description 5
- 229920003023 plastic Polymers 0.000 claims abstract description 5
- 239000004033 plastic Substances 0.000 claims abstract description 5
- 230000002631 hypothermal effect Effects 0.000 claims description 6
- 230000001939 inductive effect Effects 0.000 claims description 4
- 238000002595 magnetic resonance imaging Methods 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 238000002591 computed tomography Methods 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 238000005057 refrigeration Methods 0.000 claims description 2
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 210000001715 carotid artery Anatomy 0.000 abstract description 9
- 210000005013 brain tissue Anatomy 0.000 abstract description 5
- 210000003128 head Anatomy 0.000 abstract description 3
- 210000004072 lung Anatomy 0.000 abstract description 3
- 210000003625 skull Anatomy 0.000 abstract description 3
- 230000002792 vascular Effects 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 2
- 210000004872 soft tissue Anatomy 0.000 abstract description 2
- 239000003507 refrigerant Substances 0.000 description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 208000010496 Heart Arrest Diseases 0.000 description 1
- 206010038669 Respiratory arrest Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 238000007675 cardiac surgery Methods 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 229920002457 flexible plastic Polymers 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/10—Cooling bags, e.g. ice-bags
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0002—Head or parts thereof
- A61F2007/0009—Throat or neck
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0054—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water
- A61F2007/0056—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water for cooling
Definitions
- This invention relates to apparatus and method for cooling the brain, and in particular to apparatus and method for inducing hypothermia throughout the tissues of the brain.
- the present invention teaches the use of a light weight, easily applied neck encircling collar in firm contact with the soft tissue of the neck, and particularly in good thermal contact with the carotid arteries traversing the neck.
- a coolant flowing through channels embedded in the collar rapidly cools the blood flowing through the carotid arteries which branch into blood vessels throughout the brain providing vascular access and attendant rapid internal cooling throughout the brain including its deepest recesses. Placing the collar on the patient's neck is easily and quickly accomplished simultaneously with other emergency medical techniques, such as CPR, which maintain the patient's heart and lung activity.
- the collar of the invention contains no metallic parts; the collar, including the coolant channel, may be non-metallized fabric or plastic. This allows X-ray, Cat scan, or MRI procedures to be used while the collar is in place without impairing the effectiveness of the procedure.
- a conventional endotracheal tube inserted into the trachea, is provided with an toroidal bladder surrounding the tube.
- the toroidal bladder is positioned at the back of the oral cavity, and a coolant flowing through the toroid cools blood vessels in the oral cavity which also traverse the brain, providing cooling of the brain tissue.
- the endotracheal tube and the bladder are made from materials including non- metallic fabric or plastic materials, such that these components are compatible with X - ray, MRI or CAT scan procedures.
- the coolant flowing through the channels of the collar or the toroidal bladder may be any of the well known liquid or gaseous refrigerants, for example, gaseous CO 2 , freon, or ice water, pumped through the channels of the collar or toroidal bladder in a manner known in the refrigeration art.
- FIG. 1 is a drawing of the collar of the invention
- FIG. 2 is a drawing of the collar of FIG. 1 in place around a patient's neck
- FIG. 3 is a drawing of a second embodiment of the invention.
- FIG. 4 is a drawing of the second embodiment of the invention in use with a patient.
- a substantially circular collar 10 containing a gap 11 , has a channel 12 running about the circumference of the collar 10 .
- the ends 14 , 16 of the channel 10 are sealed, leaving the gap 11 in the collar 10 .
- Inlet tube 18 and outlet tube 20 located proximate to the ends 14 , 16 , serve as entrance and exit for a coolant flowing through the collar 10 in channel 12 .
- the collar's height “X” is sufficient to cover a large portion of the carotid artery in the neck of a patient having the collar 10 in place.
- a fastener 22 such as a Velcro strip, is used to firmly secure the collar 10 about the neck of the patient.
- the collar 10 is fabricated from either a fabric or plastic having a good thermal transfer coefficient, and capable of sustaining coolant fluid flow through the channel 12 without leakage.
- the collar 10 is shown in position on the neck 24 of a patient.
- the collar 10 is in contact with the carotid artery 26 substantially over the full distance where the carotid artery 26 traverses the neck 24 .
- the collar 10 is firmly secured in position against the skin of the neck 24 , and is in solid contact over the carotid artery 26 .
- Coolant flows from the refrigerant supply 28 via the inlet tube 18 through the channel 12 of the collar 10 and back down to the refrigerant supply 28 via the outlet tube 20 , cooling the carotid artery 26 as well as other vascular vessels in the neck 24 , and attendantly the brain 30 .
- an endotracheal tube 32 known in the art, has a toroidal shaped bladder 34 positioned to surround the endotracheal tube 32 proximate the end which is inserted into a patient's trachea.
- the bladder 34 When the tube 32 is in use, (FIG. 4 ), the bladder 34 is in intimate contact with the back of the patient's oral cavity 35 .
- the bladder 34 has inlet and outlet tubes 36 , 38 which carry coolant that flows through the bladder 34 , cooling the back of the oral cavity 35 , and attendantly the blood vessels located in the oral cavity 35 . These blood vessels are both adjacent to the brain and connect to the brain, and hence cooling these blood vessels also provides cooling of the brain tissue.
- the bladder 34 may either be rubber or a flexible plastic which will conform to the shape of the oral cavity 35 , and will make firm contact with the tissues and vessels of the oral cavity 35 .
- This second embodiment of the invention may be used in conjunction with the first embodiment described above, in which case the same refrigerant supply 28 is connected to both the inlet tubes 18 , 36 and outlet tubes 20 , 38 . Or, when used alone, a refrigerant supply equivalent to the refrigerant supply 28 of FIG. 2 is connected to the tubes 36 , 38 .
- the first embodiment of the invention may be incorporated into a neck support collar used for supporting an injured patient's head.
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Thermal Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
Abstract
Rather than cooling the brain by the relatively slow heat conduction through the low heat conductivity of the bony skull and hair covering the head, the present invention teaches the use of a light weight, easily applied neck encircling collar in firm contact with the soft tissue of the neck, and particularly in good thermal contact with the carotid arteries traversing the neck. A coolant flowing through channels embedded in the collar rapidly cools the blood flowing through the carotid arteries which branch into blood vessels throughout the brain providing vascular access and attendant rapid internal cooling throughout the brain including its deepest recesses. Placing the collar on the patient's neck is easily and quickly accomplished simultaneously with other emergency medical techniques, such as CPR, which maintain the patient's heart and lung activity. The collar of the invention contains no metallic parts; the collar, including the coolant channel, may be non-metallized fabric or plastic. This allows X-ray, Cat scan, or MRI procedures to be used while the collar is in place without impairing the effectiveness of the procedure. In a second embodiment, a conventional endotracheal tube, inserted into the trachea is provided with an toroidal bladder surrounding the tube. The toroidal bladder is positioned at the back of the oral cavity, and a coolant flowing through the toroid cools blood vessels in the oral cavity which traverse the brain, providing cooling of the brain tissue.
Description
This application claims the benefit of U.S. Provisional Application No. 60/030,030 filed Nov. 4, 1996.
1. Field of the Invention
This invention relates to apparatus and method for cooling the brain, and in particular to apparatus and method for inducing hypothermia throughout the tissues of the brain.
2. Description Relative to the Prior Art
It is well known in the medical art that depriving the brain of oxygen for even a short period of time results in irreversible damage to the brain tissue. Such deprivation occurs during stroke, respiratory arrest, cardiac arrest, trauma and other severe bodily disturbances that slow or otherwise hinder the flow of oxygenated blood to the brain. However, it is also known that lowering the temperature of the brain (hypothermia) slows its metabolic activity, and reduces the chance of tissue damage when the oxygen supply is diminished.
At present, operative neurosurgery and cardiac surgery is done in many cases using hypothermia for the specific purposes of maintaining cerebral and cardiac function. In an operating room, this requires use of a cooling module in conjunction with heart/lung bypass techniques by which the patient's blood, and resultantly the patient's brain tissue, is cooled. This widespread ability to rapidly lower brain temperature by as little as four or five degrees can make an enormous difference in preservation of function. However, out in the field, when medical emergencies occur, brain cooling must quickly and expeditiously take place without access to the sophisticated equipment available in the hospital operating room. A portable brain cooling apparatus usable in the field is described in U.S. Pat. No. 5,261,399, issued in the names of Klatz et al. For use on an injured or disabled patient, the patent discloses a helmet and back plate containing cavities in which a coolant flows to cool the brain by means of heat conduction through the skull and upper spinal column.
Rather than cooling the brain by the relatively slow heat conduction through the low heat conductivity of the bony skull and hair covering the head, the present invention teaches the use of a light weight, easily applied neck encircling collar in firm contact with the soft tissue of the neck, and particularly in good thermal contact with the carotid arteries traversing the neck. A coolant flowing through channels embedded in the collar rapidly cools the blood flowing through the carotid arteries which branch into blood vessels throughout the brain providing vascular access and attendant rapid internal cooling throughout the brain including its deepest recesses. Placing the collar on the patient's neck is easily and quickly accomplished simultaneously with other emergency medical techniques, such as CPR, which maintain the patient's heart and lung activity.
The collar of the invention contains no metallic parts; the collar, including the coolant channel, may be non-metallized fabric or plastic. This allows X-ray, Cat scan, or MRI procedures to be used while the collar is in place without impairing the effectiveness of the procedure.
In a second embodiment for rapid internal cooling of the brain, a conventional endotracheal tube, inserted into the trachea, is provided with an toroidal bladder surrounding the tube. The toroidal bladder is positioned at the back of the oral cavity, and a coolant flowing through the toroid cools blood vessels in the oral cavity which also traverse the brain, providing cooling of the brain tissue.
The endotracheal tube and the bladder are made from materials including non-metallic fabric or plastic materials, such that these components are compatible with X-ray, MRI or CAT scan procedures.
The coolant flowing through the channels of the collar or the toroidal bladder may be any of the well known liquid or gaseous refrigerants, for example, gaseous CO2, freon, or ice water, pumped through the channels of the collar or toroidal bladder in a manner known in the refrigeration art.
The invention will be described with respect to the drawings, of which:
Referring to FIG. 1 , a substantially circular collar 10, containing a gap 11, has a channel 12 running about the circumference of the collar 10. The ends 14,16 of the channel 10 are sealed, leaving the gap 11 in the collar 10. Inlet tube 18 and outlet tube 20, located proximate to the ends 14,16, serve as entrance and exit for a coolant flowing through the collar 10 in channel 12. The collar's height “X” is sufficient to cover a large portion of the carotid artery in the neck of a patient having the collar 10 in place. A fastener 22, such as a Velcro strip, is used to firmly secure the collar 10 about the neck of the patient. The collar 10 is fabricated from either a fabric or plastic having a good thermal transfer coefficient, and capable of sustaining coolant fluid flow through the channel 12 without leakage.
Referring to FIG. 2 , the collar 10 is shown in position on the neck 24 of a patient. The collar 10 is in contact with the carotid artery 26 substantially over the full distance where the carotid artery 26 traverses the neck 24. The collar 10 is firmly secured in position against the skin of the neck 24, and is in solid contact over the carotid artery 26. Coolant flows from the refrigerant supply 28 via the inlet tube 18 through the channel 12 of the collar 10 and back down to the refrigerant supply 28 via the outlet tube 20, cooling the carotid artery 26 as well as other vascular vessels in the neck 24, and attendantly the brain 30.
In FIG. 3 , an endotracheal tube 32 known in the art, has a toroidal shaped bladder 34 positioned to surround the endotracheal tube 32 proximate the end which is inserted into a patient's trachea. When the tube 32 is in use, (FIG. 4), the bladder 34 is in intimate contact with the back of the patient's oral cavity 35. The bladder 34 has inlet and outlet tubes 36,38 which carry coolant that flows through the bladder 34, cooling the back of the oral cavity 35, and attendantly the blood vessels located in the oral cavity 35. These blood vessels are both adjacent to the brain and connect to the brain, and hence cooling these blood vessels also provides cooling of the brain tissue. The bladder 34 may either be rubber or a flexible plastic which will conform to the shape of the oral cavity 35, and will make firm contact with the tissues and vessels of the oral cavity 35. This second embodiment of the invention may be used in conjunction with the first embodiment described above, in which case the same refrigerant supply 28 is connected to both the inlet tubes 18, 36 and outlet tubes 20, 38. Or, when used alone, a refrigerant supply equivalent to the refrigerant supply 28 of FIG. 2 is connected to the tubes 36,38.
The invention has been described in detail with particular reference to preferred embodiments thereof, but it will be understood that variations and modifications can be effected within the spirit and scope of the invention. For example, the first embodiment of the invention may be incorporated into a neck support collar used for supporting an injured patient's head.
Claims (7)
1. Apparatus for inducing hypothermia in a patient's brain, said apparatus comprising:
a) an endotracheal tube having a first end and second end,
b) a toroidal shaped bladder surrounding said tube proximate said first end of said tube, said first end for insertion into said a patient's trachea whereby said bladder contacts the tissues and blood vessels of said a patient's oral cavity,
c) a source of liquid or gaseous coolant, said source for providing coolant to said bladder,
d) inlet and outlet coolant conducting elements connected to said toroidal shaped bladder, whereby said coolant from said source flowing through said inlet and outlet coolant conducting elements cools said bladder, further whereby when said first end of said endotracheal tube is inserted into said a patient's trachea, said coolant flowing in said bladder lowers the temperature of said the tissues and blood vessels of said a patient's oral cavity in contact with said bladder, said the tissues and blood vessels further acting as heat conducting paths from said a patient's brain to said bladder whereby the temperature of said the brain is lowered.
2. The apparatus of claim 1 wherein said endotracheal tube and said bladder comprises non-metallic fabric or plastic materials, whereby said apparatus is compatible with X-ray, MRI or CAT scan procedures.
3. The apparatus of claim 1 further comprising refrigeration means supplying said coolant.
4. A method of inducing hypothermia in a patient's brain comprising the step of:
a) cooling said brain by lowering the temperature of the blood flowing in blood vessels located in said patient's oral cavity,
b) inserting an endotracheal tube into contact with said patient's trachea, said endotracheal tube having a toroidal bladder surrounding said endotracheal tube, said bladder being in contact with blood vessels located at the rear of said patient's oral cavity,
c) flowing coolant through said bladder by means of an inlet tube to said bladder and an outlet tube from said bladder, whereby said blood vessels are lowered in temperature to cool said brain.
5. The method of claim 4 further comprising the steps of:
a) inserting an endotracheal tube into contact with said patient's trachea, said endotracheal tube having a toroidal bladder surrounding said endotracheal tube, said bladder being in contact with blood vessels located at the rear of said patient's oral cavity and
b) flowing coolant through said bladder by means of an inlet tube to said bladder and an outlet tube from said bladder, whereby said blood vessels are lowered in temperature to cool said brain.
6. A method of inducing hypothermia in a patient's brain, comprising the steps of:
a) inserting a coolant contact comprising a bladder, an inlet coolant conducting tube and an outlet coolant conducting tube into the oral cavity of the patient, the bladder being in contact with tissues proximate blood vessels located at the rear of the patient's oral cavity; and
b) flowing coolant through the bladder by means of the inlet coolant conducting tube and the outlet coolant conducting tube, whereby the tissues and blood vessels are lowered in temperature to cool the brain.
7. The method of claim 6 wherein the bladder is a toroidal bladder and the coolant contact further comprises an endotracheal tube, wherein the toroidal bladder surrounds the endotracheal tube.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/895,623 USRE39651E1 (en) | 1996-11-04 | 2001-06-27 | Apparatus for rapid cooling of the brain and method of performing same |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3003096P | 1996-11-04 | 1996-11-04 | |
US08/816,255 US5916242A (en) | 1996-11-04 | 1997-03-13 | Apparatus for rapid cooling of the brain and method of performing same |
US09/895,623 USRE39651E1 (en) | 1996-11-04 | 2001-06-27 | Apparatus for rapid cooling of the brain and method of performing same |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/816,255 Reissue US5916242A (en) | 1996-11-04 | 1997-03-13 | Apparatus for rapid cooling of the brain and method of performing same |
Publications (1)
Publication Number | Publication Date |
---|---|
USRE39651E1 true USRE39651E1 (en) | 2007-05-22 |
Family
ID=26705583
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/816,255 Ceased US5916242A (en) | 1996-11-04 | 1997-03-13 | Apparatus for rapid cooling of the brain and method of performing same |
US09/895,623 Expired - Lifetime USRE39651E1 (en) | 1996-11-04 | 2001-06-27 | Apparatus for rapid cooling of the brain and method of performing same |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/816,255 Ceased US5916242A (en) | 1996-11-04 | 1997-03-13 | Apparatus for rapid cooling of the brain and method of performing same |
Country Status (1)
Country | Link |
---|---|
US (2) | US5916242A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9320644B2 (en) | 2011-07-25 | 2016-04-26 | Neurosave, Inc. | Non-invasive systems, devices, and methods for selective brain cooling |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6248126B1 (en) * | 1998-01-12 | 2001-06-19 | The Johns Hopkins University | Technique for using heat flow management to treat brain disorders |
US6491039B1 (en) | 1998-01-23 | 2002-12-10 | Innercool Therapies, Inc. | Medical procedure |
US6585752B2 (en) | 1998-06-23 | 2003-07-01 | Innercool Therapies, Inc. | Fever regulation method and apparatus |
US6238428B1 (en) | 1998-01-23 | 2001-05-29 | Innercool Therapies, Inc. | Selective organ cooling apparatus and method employing turbulence-inducing element with curved terminations |
US6719779B2 (en) | 2000-11-07 | 2004-04-13 | Innercool Therapies, Inc. | Circulation set for temperature-controlled catheter and method of using the same |
US6231595B1 (en) | 1998-03-31 | 2001-05-15 | Innercool Therapies, Inc. | Circulating fluid hypothermia method and apparatus |
US6051019A (en) | 1998-01-23 | 2000-04-18 | Del Mar Medical Technologies, Inc. | Selective organ hypothermia method and apparatus |
US6325818B1 (en) | 1999-10-07 | 2001-12-04 | Innercool Therapies, Inc. | Inflatable cooling apparatus for selective organ hypothermia |
US6471717B1 (en) * | 1998-03-24 | 2002-10-29 | Innercool Therapies, Inc. | Selective organ cooling apparatus and method |
US7371254B2 (en) | 1998-01-23 | 2008-05-13 | Innercool Therapies, Inc. | Medical procedure |
US6383210B1 (en) | 2000-06-02 | 2002-05-07 | Innercool Therapies, Inc. | Method for determining the effective thermal mass of a body or organ using cooling catheter |
US6558412B2 (en) | 1998-01-23 | 2003-05-06 | Innercool Therapies, Inc. | Selective organ hypothermia method and apparatus |
US6251130B1 (en) | 1998-03-24 | 2001-06-26 | Innercool Therapies, Inc. | Device for applications of selective organ cooling |
US6245095B1 (en) | 1998-03-24 | 2001-06-12 | Innercool Therapies, Inc. | Method and apparatus for location and temperature specific drug action such as thrombolysis |
US6379378B1 (en) | 2000-03-03 | 2002-04-30 | Innercool Therapies, Inc. | Lumen design for catheter |
US6312452B1 (en) | 1998-01-23 | 2001-11-06 | Innercool Therapies, Inc. | Selective organ cooling catheter with guidewire apparatus and temperature-monitoring device |
US6254626B1 (en) | 1998-03-24 | 2001-07-03 | Innercool Therapies, Inc. | Articulation device for selective organ cooling apparatus |
US6096068A (en) | 1998-01-23 | 2000-08-01 | Innercool Therapies, Inc. | Selective organ cooling catheter and method of using the same |
US6491716B2 (en) | 1998-03-24 | 2002-12-10 | Innercool Therapies, Inc. | Method and device for applications of selective organ cooling |
US6261312B1 (en) | 1998-06-23 | 2001-07-17 | Innercool Therapies, Inc. | Inflatable catheter for selective organ heating and cooling and method of using the same |
US6251129B1 (en) | 1998-03-24 | 2001-06-26 | Innercool Therapies, Inc. | Method for low temperature thrombolysis and low temperature thrombolytic agent with selective organ temperature control |
US6464716B1 (en) | 1998-01-23 | 2002-10-15 | Innercool Therapies, Inc. | Selective organ cooling apparatus and method |
US6599312B2 (en) | 1998-03-24 | 2003-07-29 | Innercool Therapies, Inc. | Isolated selective organ cooling apparatus |
US6224624B1 (en) | 1998-03-24 | 2001-05-01 | Innercool Therapies, Inc. | Selective organ cooling apparatus and method |
US6576002B2 (en) | 1998-03-24 | 2003-06-10 | Innercool Therapies, Inc. | Isolated selective organ cooling method and apparatus |
US6551349B2 (en) | 1998-03-24 | 2003-04-22 | Innercool Therapies, Inc. | Selective organ cooling apparatus |
US7291144B2 (en) | 1998-03-31 | 2007-11-06 | Innercool Therapies, Inc. | Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation |
US6905494B2 (en) | 1998-03-31 | 2005-06-14 | Innercool Therapies, Inc. | Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection |
US6602276B2 (en) | 1998-03-31 | 2003-08-05 | Innercool Therapies, Inc. | Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation |
US6685732B2 (en) | 1998-03-31 | 2004-02-03 | Innercool Therapies, Inc. | Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing microporous balloon |
US6338727B1 (en) | 1998-08-13 | 2002-01-15 | Alsius Corporation | Indwelling heat exchange catheter and method of using same |
US6126684A (en) * | 1998-04-21 | 2000-10-03 | The Regents Of The University Of California | Indwelling heat exchange catheter and method of using same |
US6830581B2 (en) | 1999-02-09 | 2004-12-14 | Innercool Therspies, Inc. | Method and device for patient temperature control employing optimized rewarming |
US6962601B2 (en) | 1999-08-02 | 2005-11-08 | University Of Chicago Office Of Technology Transfer | Method for inducing hypothermia |
JP2003505190A (en) | 1999-08-02 | 2003-02-12 | ランス ビー. ベッカー, | Methods for inducing hypothermic conditions |
US7422601B2 (en) * | 1999-08-02 | 2008-09-09 | University Of Chicago Office Of Technology Transfer | Method for inducing hypothermia |
US6447474B1 (en) * | 1999-09-15 | 2002-09-10 | Alsius Corporation | Automatic fever abatement system |
US6416532B1 (en) * | 1999-09-24 | 2002-07-09 | Joel Fallik | Brain cooling apparatus and method |
US6882881B1 (en) * | 1999-10-19 | 2005-04-19 | The Johns Hopkins University | Techniques using heat flow management, stimulation, and signal analysis to treat medical disorders |
US7228171B2 (en) * | 1999-10-19 | 2007-06-05 | The Johns Hopkins University | Signal analysis, heat flow management, and stimulation techniques to treat medical disorders |
AU4713601A (en) * | 1999-12-07 | 2001-06-18 | Alsius Corporation | Method and system for treating stroke using hypothermia |
US6849072B2 (en) | 2000-04-07 | 2005-02-01 | The General Hospital Corporation | Methods and apparatus for thermally affecting tissue |
US6726708B2 (en) | 2000-06-14 | 2004-04-27 | Innercool Therapies, Inc. | Therapeutic heating and cooling via temperature management of a colon-inserted balloon |
WO2002005736A2 (en) * | 2000-07-13 | 2002-01-24 | Medtronic, Inc. | Non-invasive carotid cooler brain hypothermia medical device |
US20040034321A1 (en) * | 2000-10-05 | 2004-02-19 | Seacoast Technologies, Inc. | Conformal pad for neurosurgery and method thereof |
US6652566B2 (en) | 2000-10-05 | 2003-11-25 | Seacoast Technologies, Inc. | Neurosurgical device for thermal therapy including spiral element |
US6648880B2 (en) | 2001-02-16 | 2003-11-18 | Cryocath Technologies Inc. | Method of using cryotreatment to treat brain tissue |
US6511502B2 (en) * | 2001-02-27 | 2003-01-28 | Robert David Fletcher | Apparatus for and method of cooling a brain |
US6682552B2 (en) | 2001-09-17 | 2004-01-27 | Vivian R. Ramsden | Brain cooling device and monitoring system |
US20040064169A1 (en) * | 2002-09-30 | 2004-04-01 | Briscoe Kathleen E. | User interface for medical device |
US7087075B2 (en) * | 2002-09-30 | 2006-08-08 | Medtronic Emergency Response Systems, Inc. | Feedback system for rapid induction of mild hypothermia |
US6942686B1 (en) * | 2002-11-01 | 2005-09-13 | Coaxia, Inc. | Regulation of cerebral blood flow by temperature change-induced vasodilatation |
US7056282B2 (en) * | 2002-12-23 | 2006-06-06 | Medtronic Emergency Response Systems, Inc. | Coolant control for rapid induction of mild hypothermia |
US7300453B2 (en) * | 2003-02-24 | 2007-11-27 | Innercool Therapies, Inc. | System and method for inducing hypothermia with control and determination of catheter pressure |
US20050027173A1 (en) * | 2003-07-31 | 2005-02-03 | Briscoe Kathleen E. | Brain injury protocols |
US20060191675A1 (en) * | 2003-09-22 | 2006-08-31 | Coolhead Technologies, Inc. | Apparatus and methods for warming and cooling bodies |
US7077858B2 (en) | 2003-09-22 | 2006-07-18 | Coolhead Technologies, Inc. | Flexible heat exchangers for medical cooling and warming applications |
US20050131501A1 (en) * | 2003-12-15 | 2005-06-16 | Rowland Robert A.Iii | Apparatus and method for prevention and treatment of infection |
US20060036302A1 (en) * | 2004-05-28 | 2006-02-16 | Kasza Kenneth E | Methods of inducing protective hypothermia of organs |
US20060079820A1 (en) * | 2004-09-30 | 2006-04-13 | Heart Core, L.L.C. | Cervical Immobilization Collar with Arterial Cooling Elements |
US20060161232A1 (en) * | 2005-01-18 | 2006-07-20 | Kasza, Oras and Son to The University of Chicago | Phase-change particulate ice slurry coolant medical delivery tubing and insertion devices |
US7389653B2 (en) * | 2005-09-15 | 2008-06-24 | The University Of Chicago | Medical ice slurry production device |
US8267877B2 (en) * | 2005-09-28 | 2012-09-18 | Life Core Technologies, Llc | Cervical immobilization collar with arterial cooling elements |
US8267878B2 (en) * | 2005-09-28 | 2012-09-18 | Life Core Technologies, Llc | Arterial cooling elements for use with a cervical immobilization collar |
US9226847B2 (en) | 2005-09-28 | 2016-01-05 | Cryothermic Systems, Inc. | Arterial cooling elements for use with a cervical immobilization collar |
US8262597B2 (en) * | 2005-09-28 | 2012-09-11 | Life Core Technologies, Llc | Cervical immobilization collar with arterial cooling elements and method of using the same |
US9084670B2 (en) | 2005-09-28 | 2015-07-21 | Cryothermic Systems, Inc. | Cervical immobilization collar with arterial cooling elements and method of using the same |
US9089411B2 (en) | 2005-09-28 | 2015-07-28 | Cryothermic Systems, Inc. | Cervical immobilization collar with arterial cooling elements and method of using the same |
US7572268B2 (en) * | 2005-10-13 | 2009-08-11 | Bacoustics, Llc | Apparatus and methods for the selective removal of tissue using combinations of ultrasonic energy and cryogenic energy |
US7842032B2 (en) | 2005-10-13 | 2010-11-30 | Bacoustics, Llc | Apparatus and methods for the selective removal of tissue |
US20070088386A1 (en) * | 2005-10-18 | 2007-04-19 | Babaev Eilaz P | Apparatus and method for treatment of soft tissue injuries |
US8236038B2 (en) * | 2006-04-20 | 2012-08-07 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Method and apparatus of noninvasive, regional brain thermal stimuli for the treatment of neurological disorders |
US8425583B2 (en) | 2006-04-20 | 2013-04-23 | University of Pittsburgh—of the Commonwealth System of Higher Education | Methods, devices and systems for treating insomnia by inducing frontal cerebral hypothermia |
US9211212B2 (en) | 2006-04-20 | 2015-12-15 | Cerêve, Inc. | Apparatus and method for modulating sleep |
US11684510B2 (en) | 2006-04-20 | 2023-06-27 | University of Pittsburgh—of the Commonwealth System of Higher Education | Noninvasive, regional brain thermal stimuli for the treatment of neurological disorders |
US9492313B2 (en) * | 2006-04-20 | 2016-11-15 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Method and apparatus of noninvasive, regional brain thermal stimuli for the treatment of neurological disorders |
US20070288074A1 (en) * | 2006-06-13 | 2007-12-13 | Gaymar Industries, Inc. | Emergency brain cooling device and method of use |
US20090221955A1 (en) * | 2006-08-08 | 2009-09-03 | Bacoustics, Llc | Ablative ultrasonic-cryogenic methods |
US20080039727A1 (en) | 2006-08-08 | 2008-02-14 | Eilaz Babaev | Ablative Cardiac Catheter System |
EP2162186B1 (en) * | 2007-07-04 | 2014-09-03 | Eliahu Arad | System for manipulating a temperature of a patient |
EP2716266B1 (en) * | 2008-01-25 | 2019-01-02 | Neurosave, Inc. | Rapid cooling of body and/or brain by irrigating aerodigestive tract with cooling liquid |
US10058674B2 (en) | 2013-01-02 | 2018-08-28 | Ebb Therapeutics, Inc. | Systems for enhancing sleep |
US9987162B2 (en) | 2014-03-21 | 2018-06-05 | The University Of Western Ontario | Mammalian head cooling system and method |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3976065A (en) | 1975-03-10 | 1976-08-24 | Gerald Durkan | Digital fluidic ventilator |
US4423725A (en) | 1982-03-31 | 1984-01-03 | Baran Ostap E | Multiple surgical cuff |
US4552149A (en) | 1982-11-19 | 1985-11-12 | Kabushiki Kaisha Dunlop Home Products | Head cooling implement |
WO1991005528A1 (en) * | 1989-10-19 | 1991-05-02 | Granulab B.V. | Device for cooling or heating a person |
US5261399A (en) | 1991-05-22 | 1993-11-16 | Klatz Ronald M | Brain cooling device and method for performing the same |
US5314456A (en) | 1993-03-19 | 1994-05-24 | Cohen Gary M | Therapeutic pad for relief of headache-related head, temple, neck and back pain |
US5480417A (en) * | 1988-11-21 | 1996-01-02 | Technomed Medical Systems | Method and apparatus for the surgical treatment of tissues by thermal effect, and in particular the prostate, using a urethral microwave-emitting probe means |
US6149624A (en) * | 1998-02-05 | 2000-11-21 | Mcshane; Richard Houston | Apparatus and method for the rapid induction of hypothermic brain preservation |
US6321121B1 (en) * | 1996-11-15 | 2001-11-20 | Brian D. Zelickson | Device and method for treatment of gastroesophageal reflux disease |
US6325818B1 (en) * | 1999-10-07 | 2001-12-04 | Innercool Therapies, Inc. | Inflatable cooling apparatus for selective organ hypothermia |
-
1997
- 1997-03-13 US US08/816,255 patent/US5916242A/en not_active Ceased
-
2001
- 2001-06-27 US US09/895,623 patent/USRE39651E1/en not_active Expired - Lifetime
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3976065A (en) | 1975-03-10 | 1976-08-24 | Gerald Durkan | Digital fluidic ventilator |
US4423725A (en) | 1982-03-31 | 1984-01-03 | Baran Ostap E | Multiple surgical cuff |
US4552149A (en) | 1982-11-19 | 1985-11-12 | Kabushiki Kaisha Dunlop Home Products | Head cooling implement |
US5480417A (en) * | 1988-11-21 | 1996-01-02 | Technomed Medical Systems | Method and apparatus for the surgical treatment of tissues by thermal effect, and in particular the prostate, using a urethral microwave-emitting probe means |
WO1991005528A1 (en) * | 1989-10-19 | 1991-05-02 | Granulab B.V. | Device for cooling or heating a person |
US5261399A (en) | 1991-05-22 | 1993-11-16 | Klatz Ronald M | Brain cooling device and method for performing the same |
US5314456A (en) | 1993-03-19 | 1994-05-24 | Cohen Gary M | Therapeutic pad for relief of headache-related head, temple, neck and back pain |
US6321121B1 (en) * | 1996-11-15 | 2001-11-20 | Brian D. Zelickson | Device and method for treatment of gastroesophageal reflux disease |
US6149624A (en) * | 1998-02-05 | 2000-11-21 | Mcshane; Richard Houston | Apparatus and method for the rapid induction of hypothermic brain preservation |
US6325818B1 (en) * | 1999-10-07 | 2001-12-04 | Innercool Therapies, Inc. | Inflatable cooling apparatus for selective organ hypothermia |
Non-Patent Citations (1)
Title |
---|
Critical Care Medicine, 1996, vol. 24, No. 6, pp. 911-914. * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9320644B2 (en) | 2011-07-25 | 2016-04-26 | Neurosave, Inc. | Non-invasive systems, devices, and methods for selective brain cooling |
Also Published As
Publication number | Publication date |
---|---|
US5916242A (en) | 1999-06-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
USRE39651E1 (en) | Apparatus for rapid cooling of the brain and method of performing same | |
US8303637B2 (en) | Catheter for topical cooling and topical cooling device using the same | |
US7303579B2 (en) | Apparatus for altering the body temperature of a patient | |
US7156867B2 (en) | Uniform selective cerebral hypothermia | |
US5913885A (en) | Brain cooling device and method for cooling | |
EP1729702B1 (en) | Cerebral temperature control | |
US6652566B2 (en) | Neurosurgical device for thermal therapy including spiral element | |
JP4658612B2 (en) | Method and apparatus for rapidly inducing and maintaining hypothermia | |
US20080097561A1 (en) | Dual cycle thermal system and method of use | |
US20060030915A1 (en) | Method and apparatus for reducing body temperature of a subject | |
US20070021808A1 (en) | Patient cooling system and method | |
US6623514B1 (en) | Method of cooling an organ | |
US20060175543A1 (en) | Intra-thecal catheter and method for cooling the spinal cord | |
US3220414A (en) | Surgical cannula | |
US7144418B1 (en) | Method, and system for selective cerebral hypothermia | |
US20230010829A1 (en) | Patient targeted temperature management device and method | |
US20070288074A1 (en) | Emergency brain cooling device and method of use | |
US6733518B2 (en) | Method and apparatus for thermal therapy | |
CN221180873U (en) | Pressure sore prevention water pillow for intensive care unit | |
Vidne et al. | Surface-induced profound hypothermia in infant cardiac operations: a new system | |
US20060111764A1 (en) | Medical device having a dual fluid circulation structure for thermally affecting tissue | |
WO2022198090A1 (en) | Devices and methods for regulating temperature of organs during or before surgical procedures | |
JPS5967947A (en) | Body heating apparatus | |
Kuhnen et al. | Cooling methods |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FPAY | Fee payment |
Year of fee payment: 8 |
|
SULP | Surcharge for late payment |
Year of fee payment: 7 |
|
AS | Assignment |
Owner name: PEACOCK MYERS, P.C., NEW MEXICO Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:SCHWARTZ, GEORGE;REEL/FRAME:020532/0417 Effective date: 20080201 |
|
FPAY | Fee payment |
Year of fee payment: 12 |