USRE32145E - Orally active tolciclate .[.(and tolnaftate).]. - Google Patents

Orally active tolciclate .[.(and tolnaftate).]. Download PDF

Info

Publication number
USRE32145E
USRE32145E US06/668,452 US66845284A USRE32145E US RE32145 E USRE32145 E US RE32145E US 66845284 A US66845284 A US 66845284A US RE32145 E USRE32145 E US RE32145E
Authority
US
United States
Prior art keywords
tolciclate
tolnaftate
iaddend
iadd
antifungal agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
US06/668,452
Inventor
Irving Shemano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hercules LLC
Original Assignee
Hercules LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hercules LLC filed Critical Hercules LLC
Priority to US06/668,452 priority Critical patent/USRE32145E/en
Application granted granted Critical
Publication of USRE32145E publication Critical patent/USRE32145E/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Definitions

  • This invention relates to treating fungal diseases. More particularly, this invention relates to the systemic treatment of fungal diseases by oral administration of .[.an antifungal agent selected from.]. tolciclate .[.and tolnaftate.]. and to medicaments containing said .[.agents.]. .Iadd.agent .Iaddend.for oral administration.
  • the human body is subject to many fungal infections, some of which have been a problem to man since before recorded history. Modern science has been successful in treating many fungal diseases. The most success has occurred in the topical treatment on exposed areas of the body. Numerous compounds are known to be effective in such topical treatment. However, not all fungal infections occur in exposed areas and are thus not amenable to topical treatment. Some fungal diseases occur internally or deep in the dermal layer of the skin or in unexposed areas, such as under fingernails, and can only be treated systemically. Unfortunately, only a few antifungal agents are known to be systemically effective when administered orally. One of the most widely prescribed drugs for the systemic treatment of fungal diseases is griseofulvin. Since the chronic feeding of this drug to mice results in their developing liver tumors, its use is not justified in minor or trivial infections. Accordingly, there is great interest in finding antifungal agents which can be effectively and safely administered orally.
  • Tolciclate .[.and tolnaftate are.]. .Iadd.is a .Iaddend.known antifungal .[.agents.]. .Iadd.agent .Iaddend.effective in topical treatment of fungal diseases.
  • Tolciclate i.e., O-(1,4-methano-1,2,3,4-tetrahydro-6-naphthyl)N-methyl-N-(m-tolyl)-thiocarbamate having the formula ##STR1## is described in U.S. Pat. No. 3,855,263. The patent indicates that the compound has antifungal activity when applied topically.
  • this invention relates to (1) the method of treating fungal diseases which comprises orally administering to a person suffering therefrom a therapeutic amount of .[.antifungal agent selected from.]. tolciclate .[.and tolnaftate.]. and (2) an antifungal medicament for oral administration comprising:
  • LD 50 lethal dose to 50% of the animals being tested.
  • .[.Tolnaftate administered orally to rats was found to have an LD 50 of greater than 5000 mg/kg..].
  • Typical fungus infections which can be treated systemically according to the process of this invention are ringworm infections of the skin, hair and nails, namely tinea corporis, tinea pedis, tinea cruris, tinea barbae, tinea capitis, tinea unguium and tinea versicolor when caused by organisms such as Microspora, Trichophyta, Epidermophyton floccosums, and Pityrospora, i.e. P. obiculare and P. ovale.
  • Typical dosage forms are as follows:
  • the gums are dispersed in about 1/2 the volume of water heated to 70° C. and then cooled to 35° C.
  • the sucrose and D&C Red dye are dissolved in a small volume of the water and added to the gum dispersion.
  • the tolciclate is dispersed in water and added to the gum dispersion.
  • the parabens, vanillin and Alva Cherry flavoring are dissolved in alcohol and added to the dispersion.
  • a quantity (7 grams) of adipic acid sufficient to adjust the pH to between 5 and 6 is added and finally the volume is adjusted to 10 liters with purified water.
  • sustained release formulations and formulations containing other medicinal agents such as analgesics, antibiotics, etc.
  • This example illustrates the absorption of tolciclate after oral administration and its migration to the skin.
  • mice Fifteen male, Swiss-Webster mice weighing 25-30 g were divided into groups of three. All animals were fasted overnight prior to the experiment. Food was allowed 8 hours after dosing.
  • 14 C-tolciclate O-(1,4-methano-1,2,3,4-tetrahydro-6-naphthyl)N-methyl-N-m-tolyl[methyl-.sup.14 C]thiocarbamate, was prepared at a specific activity of 7.48 ⁇ Ci/mg. Powdered 14 C-tolciclate was suspended in 0.25% aqueous solution of methylcellulose at a concentration of 0.5 mg/ml. Each animal was gavaged with 10 mg/ml of suspension, resulting in a 5 mg/kg dose.
  • Blood samples were taken at 0.5, 1, 2, 4, 8, 12, 48 and 72 hours after the dose of 14 C-tolciclate. At 4 hours post-dose, 3 animals were killed and the liver, kidney, lung, skin, heart, spleen and brain tissues were removed. This procedure was repeated with 3 animals at 8, 24 and 72 hours. An estimation of biliary excretion was obtained by giving an intraperitoneal injection of 5 mg/kg of 14 C-tolciclate to 2 mice and following fecal elimination over a 72 hour period. Another group of 3 mice received a daily oral dose of 5 mg/kg of 14 C-tolciclate for 8 days. Blood was taken at 1, 5 and 8 days. The same tissues listed above were taken from this group on day 8.
  • the major route of elimination was biliary, while about 25% of the dose was excreted via the urine.
  • the drug was extensively metabolized, unchanged tolciclate was not found in the urine and only minute amounts were present in the blood.
  • the major compound, identified by chromatography, in the skin was unmetabolized tolciclate. Based on the analysis, tolciclate levels in the skin ranged from 147-180 ng/g 4 hours after oral administration--this is a concentration that has been shown effective in in vitro antifungal testing.
  • the blood concentration of 14 C-tolciclate in the mice following oral administration is shown in Table 1 below.
  • This example illustrates the effectiveness of tolciclate, .[.tolnaftate.]. and griseofulvin as antifungal agents when administered orally.
  • .[.Four.]. .Iadd.Three .Iaddend.groups of albino guinea pigs were observed for two weeks to make sure they were disease free. Following the observation period they were dosed according to the following regimen: One group (the control) was gavaged twice a day for 10 days with a 0.25% aqueous methylcellulose solution. The second group was gavaged twice a day for 10 days with 50 mg/kg of tolciclate suspended in a 0.25% aqueous solution of methylcellulose. The third group was gavaged twice a day for 10 days with 50 mg/kg of .[.tolnaftate suspended in a 0.25% aqueous solution of methylcellulose. The fourth group was gavaged twice a day for 10 days with 50 mg/kg of.]. griseofulvin in the form of a commercial elixir ("Grifulvin V" sold by Ortho Pharmaceutical Corp.).
  • T. mentagrophytes "1782" fungus On the fifth day of treatment all of the animals were infected with T. mentagrophytes "1782" fungus by the following method: An area of several centimeters on the back of each guinea pig was shaved free of hair, abraded and inoculated with a suspension of a culture of T. mentagrophytes suspended in physiological saline solution. The resulting skin lesions were checked on day 7, 10 and 15 after inoculation and the size of the lesions measured. On days 10 and 15 clinical infections i.e., grossly observable skin lesions, were observed in fourteen out of the fourteen controls, seven out of the fifteen tolciclate treated animals, .[.twelve out of the twenty tolnaftate treated animals.]. and four out of the nineteen griseofulvin treated animals. The average size of the infection site and the day it was measured are tabulated in Table 4.

Landscapes

  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

It has been found that fungal diseases can be effectively treated systemically by oral administration of tolciclate .[.or tolnaftate.].. The .[.drugs.]. .Iadd.drug .Iaddend.will generally be administered in divided daily doses in the form of tablets, capsules, syrups or suspensions.

Description

BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to treating fungal diseases. More particularly, this invention relates to the systemic treatment of fungal diseases by oral administration of .[.an antifungal agent selected from.]. tolciclate .[.and tolnaftate.]. and to medicaments containing said .[.agents.]. .Iadd.agent .Iaddend.for oral administration.
2. Description of the Prior Art
The human body is subject to many fungal infections, some of which have been a problem to man since before recorded history. Modern science has been successful in treating many fungal diseases. The most success has occurred in the topical treatment on exposed areas of the body. Numerous compounds are known to be effective in such topical treatment. However, not all fungal infections occur in exposed areas and are thus not amenable to topical treatment. Some fungal diseases occur internally or deep in the dermal layer of the skin or in unexposed areas, such as under fingernails, and can only be treated systemically. Unfortunately, only a few antifungal agents are known to be systemically effective when administered orally. One of the most widely prescribed drugs for the systemic treatment of fungal diseases is griseofulvin. Since the chronic feeding of this drug to mice results in their developing liver tumors, its use is not justified in minor or trivial infections. Accordingly, there is great interest in finding antifungal agents which can be effectively and safely administered orally.
Tolciclate .[.and tolnaftate are.]. .Iadd.is a .Iaddend.known antifungal .[.agents.]. .Iadd.agent .Iaddend.effective in topical treatment of fungal diseases. Tolciclate, i.e., O-(1,4-methano-1,2,3,4-tetrahydro-6-naphthyl)N-methyl-N-(m-tolyl)-thiocarbamate having the formula ##STR1## is described in U.S. Pat. No. 3,855,263. The patent indicates that the compound has antifungal activity when applied topically. .[.Tolnaftate, i.e., methyl-(3-methylphenyl)carbamothioic acid O-2-naphthalenyl ester having the formula ##STR2## is described in U.S. Pat. No. 3,334,126. This patent indicates that tolnaftate has antifungal activity when applied topically..]. All indications have been that tolciclate .[.and tolnaftate are.]. .Iadd.is .Iaddend.only effective in topical treatment of fungal disease. .[.In fact, T. Noguchi et al, in an article entitled "Antitrichophyton Activity of Naphthiomates", on pages 259-267 of Antimicrobial Agents and Chemotherapy (1962), states (page 265) that tolnaftate was found to be "totally ineffective by oral and parenteral administration" against fungal disease and "only griseofulvin was effective". In a subsequent article entitled "Antifungal Properties of Tolnaftate In Vitro and In Vivo", by M. J. Weinstein et al, on pages 595-601 of Antimicrobial Agents and Chemotherapy (1965), the following statement appears, "Tolnaftate was found to be active only by topical application and inactive by the oral and intraperitoneal routes of administration" (bottom of page 597 to top of page 598)..].
SUMMARY OF THE INVENTION
It has now surprisingly been found that tolciclate .[.and tolnaftate.]. can be administered orally in divided daily doses to effectively combat fungal diseases. Accordingly this invention relates to (1) the method of treating fungal diseases which comprises orally administering to a person suffering therefrom a therapeutic amount of .[.antifungal agent selected from.]. tolciclate .[.and tolnaftate.]. and (2) an antifungal medicament for oral administration comprising:
a. from about 10% to about 90% by weight of an .[.antifungal agent selected from.]. tolciclate and .[.tolnaftate..].
b. from about 90% to 10% by weight of a pharmaceutically acceptable carrier.
Unlike some antifungal agents, the orally administered .[.agents.]. .Iadd.agent .Iaddend.of this invention .[.are.]. .Iadd.is .Iaddend.relatively nontoxic. For example, when administered orally to rats, tolciclate was found to have an LD50 of greater than 4000 mg/kg. By the term "LD50 " is meant lethal dose to 50% of the animals being tested. .[.Tolnaftate administered orally to rats was found to have an LD50 of greater than 5000 mg/kg..].
The .[.agents.]. .Iadd.agent .Iaddend.of this invention .[.are.]. .Iadd.is .Iaddend.effective against a wide spectrum of fungal diseases. Typical fungus infections which can be treated systemically according to the process of this invention are ringworm infections of the skin, hair and nails, namely tinea corporis, tinea pedis, tinea cruris, tinea barbae, tinea capitis, tinea unguium and tinea versicolor when caused by organisms such as Microspora, Trichophyta, Epidermophyton floccosums, and Pityrospora, i.e. P. obiculare and P. ovale.
Oral dosages in the order of 1 to 50 mg/kg, most preferably 5 to 25 mg/kg daily of the agents .[.are.]. .Iadd.is .Iaddend.highly effective in suppressing fungal diseases. Most preferably the .[.agents.]. .Iadd.agent .Iaddend.will be administered in divided daily doses. The specific dosage will depend upon the site of the infection, type of fungus, and duration of treatment. Any pharmaceutical composition for oral administration containing the .[.agents.]. .Iadd.agent .Iaddend.can be used in the process of this invention. In general, however, the .[.agents.]. .Iadd.agent .Iaddend.will be administered in the form of tablets, capsules, syrups or suspensions.
Typical dosage forms are as follows:
A. The following ingredients are mixed in a blender for 5 minutes and then compressed into 200 mg. tablets:
______________________________________                                    
Ingredients         Grams per 1000 tablets                                
______________________________________                                    
Tolciclate          100         g.                                        
Lactose, USP        50          g.                                        
Microcrystalline Cellulose, USP                                           
                    49          g.                                        
Magnesium Stearate, USP                                                   
                    1           g.                                        
______________________________________
.[.B. The following ingredients are mixed in a blender for 5 minutes and then 250 mg. portions are filled into hard gelatin capsules:
______________________________________                                    
Ingredients      Grams per 1000 capsules                                  
______________________________________                                    
Tolnaftate       100         g.                                           
Lactose, USP     100         g.                                           
Starch, USP      48          g.                                           
Magnesium Stearate, USP                                                   
                 2           g..].                                        
______________________________________
.[.C..]. .Iadd.B. .Iaddend.The following ingredients are utilized in forming a suspension:
______________________________________                                    
Ingredients         Per 10 liters                                         
______________________________________                                    
Tolciclate          100       g.                                          
Cellulose gum 7MF   80        g.                                          
Veegum              100       g.                                          
Sucrose, USP        1500      g.                                          
Alcohol, USP        500       ml.                                         
Methylparaben, USP  20        g.                                          
Propylparaben, USP  5         g.                                          
Vanillin, USP       0.5       mg.                                         
Alva Cherry V-41    50        ml.                                         
D&C Red No. 33      0.7       g.                                          
Adipic Acid, FCC (qs pH 5-6)                                              
                    7         g.                                          
Purified water, USP qs                                                    
                    10        liters                                      
______________________________________
The gums are dispersed in about 1/2 the volume of water heated to 70° C. and then cooled to 35° C. The sucrose and D&C Red dye are dissolved in a small volume of the water and added to the gum dispersion. Next, the tolciclate is dispersed in water and added to the gum dispersion. The parabens, vanillin and Alva Cherry flavoring are dissolved in alcohol and added to the dispersion. A quantity (7 grams) of adipic acid sufficient to adjust the pH to between 5 and 6 is added and finally the volume is adjusted to 10 liters with purified water.
Various other dosage forms will be obvious to those skilled in the art, including sustained release formulations and formulations containing other medicinal agents such as analgesics, antibiotics, etc.
The following examples are presented to illustrate the process of this invention.
EXAMPLE 1
This example illustrates the absorption of tolciclate after oral administration and its migration to the skin.
Fifteen male, Swiss-Webster mice weighing 25-30 g were divided into groups of three. All animals were fasted overnight prior to the experiment. Food was allowed 8 hours after dosing.
14 C-tolciclate, O-(1,4-methano-1,2,3,4-tetrahydro-6-naphthyl)N-methyl-N-m-tolyl[methyl-.sup.14 C]thiocarbamate, was prepared at a specific activity of 7.48μ Ci/mg. Powdered 14 C-tolciclate was suspended in 0.25% aqueous solution of methylcellulose at a concentration of 0.5 mg/ml. Each animal was gavaged with 10 mg/ml of suspension, resulting in a 5 mg/kg dose.
Blood samples were taken at 0.5, 1, 2, 4, 8, 12, 48 and 72 hours after the dose of 14 C-tolciclate. At 4 hours post-dose, 3 animals were killed and the liver, kidney, lung, skin, heart, spleen and brain tissues were removed. This procedure was repeated with 3 animals at 8, 24 and 72 hours. An estimation of biliary excretion was obtained by giving an intraperitoneal injection of 5 mg/kg of 14 C-tolciclate to 2 mice and following fecal elimination over a 72 hour period. Another group of 3 mice received a daily oral dose of 5 mg/kg of 14 C-tolciclate for 8 days. Blood was taken at 1, 5 and 8 days. The same tissues listed above were taken from this group on day 8.
All of the materials collected from the mice were assayed for 14 C by liquid scintillation counting on a Packard 2425 scintillation counter. Solid material was combusted using a Packard 306 Sample oxidizer prior to liquid scintillation counting. Samples of the skin and lyophilized urine were extracted with methanol and samples of the blood were extracted with ethyl acetate and the extracts analyzed by thin layer chromatography. Analysis of fecal and urine data following the single 5 mg/kg dose showed that at least 70% of the tolciclate administered orally to the mice was absorbed. The absorption appeared to be rapid with a peak level in the blood during the first hour or two. The major route of elimination was biliary, while about 25% of the dose was excreted via the urine. The drug was extensively metabolized, unchanged tolciclate was not found in the urine and only minute amounts were present in the blood. However, the major compound, identified by chromatography, in the skin was unmetabolized tolciclate. Based on the analysis, tolciclate levels in the skin ranged from 147-180 ng/g 4 hours after oral administration--this is a concentration that has been shown effective in in vitro antifungal testing.
The blood concentration of 14 C-tolciclate in the mice following oral administration is shown in Table 1 below.
              TABLE 1                                                     
______________________________________                                    
             Tolciclate Equivalent                                        
Time (hours) (ng/g)                                                       
______________________________________                                    
0.5          469.5 ± 46.9                                              
1.0          618.1 ± 59.4                                              
2.0          364.5 ± 57.9                                              
4.0          229.3 ± 20.5                                              
8.0          210.0 ± 8.1                                               
24.0         72.5 ± 6.2                                                
48.0          60.3 ± 13.2                                              
72.0          48.8 ± 10.6                                              
______________________________________
The concentration of tolciclate in the skin of the mice following a single oral dose (μg/g wet tissue) is given in Table 2.
              TABLE 2                                                     
______________________________________                                    
Hours       Concentration*                                                
______________________________________                                    
4           0.21 ± 0.04                                                
8           0.16 ± 0.01                                                
24          0.11 ± 0.02                                                
72          0.03 ± 0.00                                                
______________________________________                                    
 *The data are given as tolciclate equivalents in mean ± SEM (n = 3).
The concentration of tolciclate in the tissue of the mice following eight oral daily doses is given in Table 3.
              TABLE 3                                                     
______________________________________                                    
Tissue      g/g wet tissue*                                               
______________________________________                                    
Liver       1.25 ± 0.12                                                
Kidney      0.41 ± 0.05                                                
Lung        0.22 ± 0.02                                                
Skin        0.13 ± 0.02                                                
Heart       0.07 ± 0.01                                                
Spleen      0.06 ± 0.00                                                
Brain       0.03 ± 0.00                                                
______________________________________                                    
 *Tissues were taken 24 hours after the last dose. The data are given as  
 tolciclate equivalent in mean ± SEM (n = 3).
EXAMPLE 2
This example illustrates the effectiveness of tolciclate, .[.tolnaftate.]. and griseofulvin as antifungal agents when administered orally.
.[.Four.]. .Iadd.Three .Iaddend.groups of albino guinea pigs were observed for two weeks to make sure they were disease free. Following the observation period they were dosed according to the following regimen: One group (the control) was gavaged twice a day for 10 days with a 0.25% aqueous methylcellulose solution. The second group was gavaged twice a day for 10 days with 50 mg/kg of tolciclate suspended in a 0.25% aqueous solution of methylcellulose. The third group was gavaged twice a day for 10 days with 50 mg/kg of .[.tolnaftate suspended in a 0.25% aqueous solution of methylcellulose. The fourth group was gavaged twice a day for 10 days with 50 mg/kg of.]. griseofulvin in the form of a commercial elixir ("Grifulvin V" sold by Ortho Pharmaceutical Corp.).
On the fifth day of treatment all of the animals were infected with T. mentagrophytes "1782" fungus by the following method: An area of several centimeters on the back of each guinea pig was shaved free of hair, abraded and inoculated with a suspension of a culture of T. mentagrophytes suspended in physiological saline solution. The resulting skin lesions were checked on day 7, 10 and 15 after inoculation and the size of the lesions measured. On days 10 and 15 clinical infections i.e., grossly observable skin lesions, were observed in fourteen out of the fourteen controls, seven out of the fifteen tolciclate treated animals, .[.twelve out of the twenty tolnaftate treated animals.]. and four out of the nineteen griseofulvin treated animals. The average size of the infection site and the day it was measured are tabulated in Table 4.
              TABLE 4                                                     
______________________________________                                    
Treatment    Day    Size of infection site, cm.sup.2                      
______________________________________                                    
Control      10     8.5                                                   
             15     6.7                                                   
Tolciclate   10     0.03                                                  
             15     0.09                                                  
.[.Tolnaftate                                                             
             10     0.025                                                 
             15     0.1.].                                                
Griseofulvin 10     0                                                     
             15     0.09                                                  
______________________________________
On day 10 after inoculation with T. mentagrophytes each animal was tested for the presence of fungus as described in Manual, Chemical Microbiology, 2nd Edition, Lenette, Spaulding and Truant. American Society of Microbiology, 1974, pp. 945-946. Thirteen out of the fourteen controls tested positive, indicating fungus infection on day 10. All of the treated animals were negative.

Claims (5)

What we claim and desire to protect by Letters Patent is:
1. A process of suppressing fungal disease which comprises orally administering to a person infected therewith a therapeutically effective amount for antifungal purposes of .[.an antifungal agent selected from the group consisting of.]. tolciclate .[.and tolnaftate.]..
2. The process of claim 1 where the .[.antifungal agent.]. .Iadd.tolciclate .Iaddend.is administered in the form of a tablet.
3. The process of claim 1 where the .[.antifungal agent.]. .Iadd.tolciclate .Iaddend.is administered in the form of a capsule.
4. The process of claim 1 wherein the .[.antifungal agent.]. .Iadd.tolciclate .Iaddend.is administered in the form of a liquid suspension.
5. The process of claim 1 wherein the .[.antifungal agent.]. .Iadd.tolciclate .Iaddend.is administered in divided daily doses. .[.6. the process of claim 1 where the antifungal agent is tolciclate..]. .[.7. The process of claim 1 where the antifungal agent is tolnaftate..].
US06/668,452 1984-11-05 1984-11-05 Orally active tolciclate .[.(and tolnaftate).]. Expired - Fee Related USRE32145E (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US06/668,452 USRE32145E (en) 1984-11-05 1984-11-05 Orally active tolciclate .[.(and tolnaftate).].

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/668,452 USRE32145E (en) 1984-11-05 1984-11-05 Orally active tolciclate .[.(and tolnaftate).].

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US06/258,830 Reissue US4348407A (en) 1981-04-29 1981-04-29 Orally active tolciclate and tolnaftate

Publications (1)

Publication Number Publication Date
USRE32145E true USRE32145E (en) 1986-05-13

Family

ID=24682366

Family Applications (1)

Application Number Title Priority Date Filing Date
US06/668,452 Expired - Fee Related USRE32145E (en) 1984-11-05 1984-11-05 Orally active tolciclate .[.(and tolnaftate).].

Country Status (1)

Country Link
US (1) USRE32145E (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6645473B2 (en) 2000-07-24 2003-11-11 Diana L. Hauan Combination tanning and antifungal topical system for treating tinea versicolor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3855263A (en) * 1972-03-20 1974-12-17 Erba Carlo Spa Tetrahydro-2-naphthyl ester derivatives of tinonocarbanilic acids

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3855263A (en) * 1972-03-20 1974-12-17 Erba Carlo Spa Tetrahydro-2-naphthyl ester derivatives of tinonocarbanilic acids

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Noguchi et al, Antimicrobial Agents and Chemotherapy 1962, (May, 1963) pp. 259 267. *
Noguchi et al, Antimicrobial Agents and Chemotherapy 1962, (May, 1963) pp. 259-267.
Noguchi et al, Yakugaku Zasshi (J. Pharmaceutical Society of Japan), vol. 88, No. 3, pp. 353 358 (Mar. 1968). *
Noguchi et al, Yakugaku Zasshi (J. Pharmaceutical Society of Japan), vol. 88, No. 3, pp. 353-358 (Mar. 1968).
The Merck Index, 9th Ed., Merck & Co. Inc., Rahway, N.J., 1976, p. 1224. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6645473B2 (en) 2000-07-24 2003-11-11 Diana L. Hauan Combination tanning and antifungal topical system for treating tinea versicolor

Similar Documents

Publication Publication Date Title
Malone et al. The effect of pyrazinamide (aldinamide) on experimental tuberculosis in mice
US20210069192A1 (en) Use of neutrophil elastase inhibitors in liver disease
US20080300253A1 (en) Treatment of inflammatory disorders with praziquantel
US4717716A (en) Immuno-regulator
JPS62158210A (en) Rectal absorption form of l-dopa
US6436975B1 (en) Pharmaceutical compositions for ulcer
JP2721507B2 (en) Diabetes treatment
US4058620A (en) Therapeutic agents for improving cardiovascular function
EP0399051B1 (en) Polyvalent antiinflammatory agent
US4348407A (en) Orally active tolciclate and tolnaftate
JPH0140804B2 (en)
USRE32145E (en) Orally active tolciclate .[.(and tolnaftate).].
CA1141662A (en) Pharmaceutical compositions containing paracetamol
US4520132A (en) Use of undecylenic acid to treat herpes labialis
US20060287353A1 (en) Method for preventing or treating ischemia-or hemorrhage-induced brain damage using a macrolide compound
Modell Drugs in Current Use 1958
DE69717961T2 (en) USE OF A FLAVONOID-EXTRACT OF THE PLANTS EUPHORBIA PROSTRATA FOR THE PRODUCTION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF INORACTAL OR COLON DISORDERS
USRE32990E (en) Use of undercylenic acid to treat herpes labialis
GB1581912A (en) Compositions containing n-(2-amino-3,5-dibromo benzyl) - n -methyl-cyclohexylamine and/or its salts
EP0914122B1 (en) Method for treating and preventing neurodegenerative disorders by administering a thiazolidinone
US4012516A (en) Pharmacologically active compositions
JPS60208914A (en) Preventive and remedy for hepatic disorder
CN119302961A (en) A hypoglycemic drug composition containing compound A
US4177281A (en) Therapeutic treatment for measles viral infection
CN119302978A (en) A compound hypoglycemic drug composition

Legal Events

Date Code Title Description
REMI Maintenance fee reminder mailed
LAPS Lapse for failure to pay maintenance fees