USRE32087E - 4H-3,1-Benzoxazine derivatives - Google Patents

4H-3,1-Benzoxazine derivatives Download PDF

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USRE32087E
USRE32087E US06/506,316 US50631683A USRE32087E US RE32087 E USRE32087 E US RE32087E US 50631683 A US50631683 A US 50631683A US RE32087 E USRE32087 E US RE32087E
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Gerhard Hamprecht
Bruno Wuerzer
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/86—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
    • A01N47/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom containing >N—S—C≡(Hal)3 groups
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/30—Derivatives containing the group >N—CO—N aryl or >N—CS—N—aryl
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/48—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —S—C≡N groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4

Definitions

  • the present invention relates to 4H-3,1-benzoxazine derivatives, herbicides containing these compounds as active ingredients, and a process for controlling undesired plant growth with these compounds.
  • Substituted 4H-3,1-benzoxazin-4-ones are known as intermediates for the synthesis of drugs (German Laid-Open Applications DOS Nos. 1,670,375 and 3,556,590) and as herbicidal active ingredients; in particular, 4H-3,1-benzoxazin-4-ones which carry an unsubstituted or substituted phenyl radical in the 2-position are herbicidally active (Belgian Pat. No. 648,259 and U.S. Pat. Nos. 3,970,652 and 3,914,121).
  • the known compounds are well tolerated by a number of crops, eg. species of grain, rice, Indian corn and sorghum. Their shortcomings reside in a narrow spectrum of action on broad-leaved weeds. Furthermore, even in the case of plants which these benzoxazines control effectively, relatively large amounts per unit area must be used.
  • R 1 is hydrogen, halogen, nitro, alkyl, haloalkyl, haloalkoxy or haloalkylmercapto, each of 1 to 4 carbon atoms, cyano, thiocyano, CO 2 R 3 , ##STR3## Y'R 4 , SOR 4 , SO 2 R 4 , SO 2 OR 4 , ##STR4## or CO--R 4 , where R 3 is alkyl or alkenyl of up to 4 carbon atoms,
  • R 4 is alkyl of 1 to 4 carbon atoms
  • R 5 is hydrogen or alkyl of 1 to 4 carbon atoms
  • Y' is oxygen or sulfur
  • R 2 is a cycloaliphatic or bicycloaliphatic radical of 3 to 10 carbon atoms which is monosubstituted or polysubstituted by methyl, or is a pyrimidine, pyrazine, pyridazine, triazine, thiazole, isothiazole, pyrazole, imidazole, triazole, oxazole or isoxazole radical which is unsubstituted or is monosubstituted or polysubstituted by methyl and/or halogen, or is a furan, morpholine or pyridine radical which is monosubstituted or polysubstituted by methyl and/or halogen, and, if R 1 is hydrogen, R 2 may also be an m-substituted or p-substituted, or m- and p-substituted, aryl radical of the formula Ar(R 6 ) n , where Ar is phen
  • R 6 may also denote hydrogen, halogen, cyano, thiocyano, nitro, haloalkyl of 1 to 4 carbon atoms or acyl of 2 to 5 carbon atoms, and if R 1 denotes fluorine or hydrogen and n is 2, R 6 may also denote hydrogen, fluorine, chlorine, nitro or alkoxycarbonyl of 2 to 5 carbon atoms, and if R 1 denotes halogen and n is 1, R 6 may also denote haloalkoxy, haloalkylmercapto or alkylsulfinyl, and if R 1 denotes hydrogen, R 2 may also be aralkyl substituted in the m-position or p-position or m- and p-position, by haloalkyl or haloalkoxy, each of 1 to 4 carbon atoms, are excellently tolerated by crop plants and exhibit a substantially more powerful herbicidal action than the benzoxazines hitherto disclosed.
  • R 1 is, for example, hydrogen, fluorine, chlorine, bromine, iodine, nitro, methyl, ethyl, isopropyl, n-propyl, n-butyl, isobutyl, tert.-butyl, trichloromethyl, difluorochloromethyl, trifluoromethyl, difluoromethyl, 2,2,1,1-tetrafluoroethyl, trifluoromethoxy, hexafluoroisopropoxy, difluoromethylmercapto, trifluoromethylmercapto, a radical of the formula Y"CF 2 C(Z) 3 , where Y" is oxygen or sulfur and each Z independently may be hydrogen, fluorine, chlorine, bromine or iodine, eg.
  • R 2 in formula I is, for example, cyclopentyl, cyclohexyl, ⁇ - , ⁇ - or ⁇ -methylcyclopentyl, ⁇ - , ⁇ - or ⁇ -methylcyclohexyl, 1,4-methano-bicyclo-(4,3)-nonane, 2-methyl-fur-3-yl, 3-methyl-fur-2-yl, 4-methyl-fur-2-yl, 5-methyl-fur-2-yl, 2-methyl-fur-4-yl, 3-methyl-fur-4-yl, 2,5-dimethyl-fur-4-yl, 4-methyl-pyrid-2-yl, 5-methyl-pyrid-2-yl, 2-methyl-pyrid-4-yl, 2-methyl-pyrid-5-yl, 3-chloro-pyrid-5-yl, 2-chloro-pyrid-4-yl, 2-chloro-pyrid-5-yl, pyrimidin-2-yl, -4-yl, -5-yl
  • Preferred compounds of the formula I are those where R 1 is hydrogen, R 2 is substituted phenyl, R 6 is haloalkoxy, haloalkylmercapto or alkylsulfinyl, each of 1 to 4 carbon atoms, and n is 1, or where R 1 is halogen, R 2 is substituted phenyl, R 6 is haloalkoxy, haloalkylmercapto or alkylsulfinyl, each of 1 to 4 carbon atoms, and n is 1, those where R 1 is hydrogen, R 2 is substituted phenyl, R 6 is halogen, haloalkoxy, haloalkylmercapto or alkylsulfinyl, each of 1 to 4 carbon atoms, and n is 2, or those where R 1 is fluorine, R 2 is unsubstituted or substituted phenyl, R 6 is hydrogen or halogen and n is 2.
  • benzoxazine derivatives of the formula I are obtained if an unsubstituted or substituted anthranilic acid of the formula II ##STR9## where R 1 and Y have the above meanings, is reacted with a twofold or even higher molar excess of a carboxylic acid halide of the formula III ##STR10## where R 2 has the above meanings and Hal is halogen, especially fluorine, chlorine or bromine, in an aromatic tertiary amine as the solvent, at from 10° to 60° C.
  • a twofold molar excess of the carboxylic acid halide of the formula III is run into a solution of the unsubstituted or substituted anthranilic acid of the formula II in from 5 to 25 moles of an aromatic amine per mole of anthranilic acid, at from 10° to 60° C., after which stirring is continued for 30 minutes at 25° C. (cf. J. Chem. Soc. (C) (1968), 1593).
  • the batch can then be worked up by stirring ice-water into the mixture and filtering off the precipitate which forms.
  • it is possible to carry out the reaction by first taking the carboxylic acid halide and adding the anthranilic acid of the formula II.
  • aromatic tertiary amines examples include pyridine, ⁇ , ⁇ - and ⁇ -picoline, lutidine, quinoline and acridine.
  • the benzoxazine derivatives of the formula I may also be obtained by reacting an unsubstituted or substituted anthranilic acid of the formula II ##STR12## where R 1 and Y have the above meanings, or an alkali metal salt or alkaline earth metal salt of this anthranilic acid, with about the stoichiometric amount of carboxylic acid halide of the formula III ##STR13## where R 2 has the meanings given in claim 1 and Hal is halogen, in an inert organic solvent or in water, in the presence or absence of an acid acceptor, at from 0° to 60° C., to give a carboxylic acid amide of the formula IV ##STR14## where R 1 , R 2 and Y have the above meanings, and then cyclizing this amide at from 30° to 150° C. in the presence of a dehydrating agent.
  • suitable inert solvents are hydrocarbons, eg. naphtha, gasoline, toluene, pentane, hexane, cyclohexane and petroleum ether, halohydrocarbons, eg. methylene chloride, chloroform, carbon tetrachloride, 1,1- and 1,2-dichloroethane, 1,1,1- and 1,1,2-trichloroethane, chlorobenzene, o-, m- and p-dichlorobenzene and o-, m- and p-chlorotoluene, nitrohydrocarbons, eg.
  • hydrocarbons eg. naphtha
  • gasoline toluene
  • pentane hexane
  • halohydrocarbons eg. methylene chloride, chloroform, carbon tetrachloride, 1,1- and 1,2-dichloro
  • nitrobenzene nitroethane and o-, m- and p-chloronitrobenzene
  • nitriles eg. acetonitrile, butyronitrile and isobutyronitrile
  • ethers eg. diethyl ether, di-n-propyl ether, tetrahydrofuran and dioxane
  • esters eg. ethyl acetoacetate, ethyl acetate and isobutyl acetate
  • amides eg. formamide, methylformamide and dimethylformamide.
  • any of the conventional acid-binding agents may be used as the acid acceptor.
  • alkali metal hydroxides, alkali metal carbonates and tertiary organic bases are preferred.
  • Specific examples of particularly suitable compounds are sodium hydroxide, sodium carbonate, sodium bicarbonate, triethylamine, pyridine, trimethylamine, ⁇ -, ⁇ - and ⁇ -picoline, lutidine, N,N-dimethylaniline, N,N-dimethylcyclohexylamine, quinoline, tri-n-propylamine and tri-n-butylamine.
  • the acid acceptor is employed in an amount equivalent to the carboxylic acid halide of the formula III.
  • Suitable dehydrating agents are symmetrical and mixed carboxylic acid anhydrides, eg. acetic anhydride, propionic anhydride, butyric anhydride, formic-acetic anhydride, formic-propionic anhydride and acetic-propionic anhydride, as well as dicyclohexylcarbodiimide and thionyl chloride.
  • the cyclization is carried out with from 1 to 10 moles of dehydrating agent per mole of carboxylic acid amide of the formula IV.
  • the starting materials of the formulae II and III are employed in about the stoichiometric ratio, ie. to within ⁇ 10% of this ratio.
  • the process is carried out by adding the carboxylic acid halide of the formula III and the equivalent amount of acid acceptor from two separate feeds, at from 0° to 60° C., to an about equivalent amount of the anthranilic acid of the formula III, or a salt thereof, in an inert organic solvent or in water.
  • the mixture is then stirred for 15 minutes at room temperature after which it is concentrated if necessary, acidified, whilst warm, with 5 N hydrochloric acid, cooled and filtered (J. Org. Chem. 2 (1944) 396), giving a N-acyl-2-aminobenzoic acid.
  • the cyclization can also be carried out with from 1 to 4 moles of dicyclohexylcarbodiimide or thionyl chloride per mole of N-acyl-2-aminobenzoic acid, at 30°-150° C.
  • the latter may be treated with water, dilute alkali or dilute acid to separate out by-products, such as unconverted anthranilic acid, acid chloride or base hydrochloric, and may then be dried and concentrated. Where necessary, the end products can be purified by recrystallization or chromatography.
  • 3-Chloro-4-methoxybenzoic acid is converted by means of thionyl chloride, by a conventional method, to 3-chloro-4-methoxybenzoyl chloride of boiling point 106° C./0.13 mbar and melting point 45°-50° C.
  • a mixture of 86 parts by weight of 3-methoxy-4-chlorobenzoyl chloride and 5 parts by weight of phosphorus pentachloride is chlorinated for 7 hours at 195°-205° C., giving 112 parts by weight of 3-trichloromethoxy-4-chlorobenzoyl chloride of boiling point 92°-96° C./0.13 mbar.
  • 3-Nitrobenzoyl chloride and anthranilic acid are converted by a conventional method to 3-nitrobenzoylanthanilic acid, of melting point 242°-247° C. (J. Am. Chem. Soc. 33 (1911), 952).
  • a mixture of 47.4 parts by weight of m-tolyl difluoromethyl ether, 77 parts by weight of magnesium sulfate, 134.3 parts by weight of potassium permanganate and 1,900 parts by volume of water is stirred for 3 hours at 50°-60° C. for 2 hours at 90° C.
  • the solution is filtered whilst still hot and the filtrate is then acidified.
  • the precipitate formed is taken up in methylene chloride and the extract is dried; after concentrating under reduced pressure, 3-difluoromethoxybenzoic acid of melting point 85°-87° C. is obtained.
  • the active ingredients according to the invention may be applied for instance in the form of directly sprayable solutions, powders, suspensions (including high-percentage aqueous, oily or other suspensions), dispersions, emulsions, oil dispersions, pastes, dusts, broadcasting agents, or granules by spraying, atomizing, dusting, broadcasting or watering.
  • directly sprayable solutions powders, suspensions (including high-percentage aqueous, oily or other suspensions)
  • dispersions emulsions, oil dispersions, pastes, dusts, broadcasting agents, or granules by spraying, atomizing, dusting, broadcasting or watering.
  • the forms of application depend entirely on the purpose for which the agents are being used; in any case they should ensure as fine a distribution of active ingredient as possible.
  • mineral oil fractions of medium to high boiling point such as kerosene or diesel oil, further coal-tar oils, and oils of vegetable or animal origin
  • aliphatic, cyclic and aromatic hydrocarbons such as benzene, toluene, xylene, paraffin, tetrahydronaphthalene, alkylated naphthalenes and their derivatives such as methanol, ethanol, propanol, butanol, chloroform, carbon tetrachloride, cyclohexanol, cyclohexanone, chlorobenzene, isophorone, etc.
  • strongly polar solvents such as dimethylformamide, dimethylsulfoxide, N-methylpyrrolidone, water, etc. are suitable.
  • Aqueous formulations may be prepared from emulsion concentrates, pastes, oil dispersions or wettable powders by adding water.
  • emulsions, pastes and oil dispersions the ingredients as such or dissolved in an oil or solvent may be homogenized in water by means of wetting or dispersing agents, adherents or emulsifiers.
  • Concentrates which are suitable for dilution with water may be prepared from active ingredient, wetting agent, adherent, emulsifying or dispersing agent and possibly solvent or oil.
  • surfactants are: alkali metal, alkaline earth metal and ammonium salts of ligninsulfonic acid, naphthalenesulfonic acids, phenolsulfonic acids, alkylaryl sulfonates, alkyl sulfates, and alkyl sulfonates, alkali metal and alkaline earth metal salts of dibutylnaphthalenesulfonic acid, lauryl ether sulfate, fatty alcohol sulfates, alkali metal and alkaline earth metal salts of fatty acids; salts of sulfated hexadecanols, heptadecanols, and octadecanols, salts of sulfated fatty alcohol glycol ethers, condensation products of sulfonated naphthalene and naphthalene derivatives with formaldehyde, condensation products of naphthalene or naphthalenesulf
  • Powders, dusts and broadcasting agents may be prepared by mixing or grinding the active ingredients with a solid carrier.
  • Granules e.g., coated, impregnated or homogeneous granules, may be prepared by bonding the active ingredients to solid carriers.
  • solid carriers are mineral earths such as silicic acid, silica gels, silicates, talc, kaolin, Attaclay, limestone, lime, chalk, bole, loess, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, ground plastics, fertilizers such as ammonium sulfate, ammonium phosphate, ammonium nitrate, and ureas, and vegetable products such as grain flours, bark meal, wood meal, and nutshell meal, cellulosic powders, etc.
  • mineral earths such as silicic acid, silica gels, silicates, talc, kaolin, Attaclay, limestone, lime, chalk, bole, loess, clay, dolomite, diatomace
  • the formulations contain from 0.1 to 95, and preferably 0.5 to 90, % by weight of active ingredient.
  • V. 20 Parts by weight of the compound of Example 2 is well mixed with 3 parts by weight of the sodium salt of diisobutylnaphthalene- ⁇ -sulfonic acid, 17 parts by weight of the sodium salt of a lignin-sulfonic acid obtained from a sulfite waste liquor, and 60 parts by weight of powdered silica gel, and triturated in a hammer mill.
  • a spray liquor is obtained containing 0.1% by weight of the active ingredient.
  • the vessels employed were plastic flowerpots having a volume of 300 cm 3 , and which were filled with a sandy loam containing about 1.5% humus.
  • the seeds of the test plants (cf. Table 1) were sown shallow, and separately, according to species, or pregerminated young plants or cuttings were transplanted. Generally, the plants were grown to a height of 3 to 10 cm, depending on the growth shape, before being treated.
  • the compounds were emulsified or suspended in water as vehicle, and sprayed through finely distributing nozzles onto the shoot parts of the plants and the soil not completely covered by plants.
  • the pots were set up in the greenhouse--species from warmer areas at from 20° to 30° C., and species from moderate climates at 10° to 20° C.
  • the experiments were run for from 2 to 4 weeks. During this period, the plants were tended and their reactions to the various treatments assessed.
  • the scale used for assessment was 0 to 100, 0 denoting no damage or normal emergence, and 100 denoting nonemergence or complete destruction of at least the visible plant parts.
  • application techniques may be used in which the agents are sprayed from suitable equipment in such a manner that the leaves of sensitive crop plants are if possible not touched, and the agents reach the soil or the unwanted plants growing beneath the crop plants (post-directed, lay-bytreatment).
  • the agents according to the invention may be used not only on the crop plants listed in the tables, but also in a much larger range of crops for removing unwanted plants.
  • the application rates vary from 0.1 to 15 kg/ha and more.
  • the 4H-3,1-benzoxazine derivatives of the formula I may be mixed with each other, or with numerous representatives of other herbicidal or growth-regulating active ingredient groups, and applied in such combinations. These combinations extend the spectrum of action, and synergistic effects are sometimes achieved.
  • Examples of compounds which may be admixed are diazines, benzothiadiazinones, 2,6-dinitroanilines, N-phenylcarbamates, thiolcarbamates, halocarboxylic acids, triazines, amides, ureas, diphenyl ethers, triazinones, uracils, benzofuran derivatives, etc.
  • a number of active ingredients which, together with the new compounds, give mixtures useful for widely varying applications are listed below by way of example.
  • the new compounds may also be useful to apply the new compounds, either alone or in combination with other herbicides, in admixture with other crop protection agents, e.g., agents for combating pests or phytopathogenic fungi or bacteria.
  • crop protection agents e.g., agents for combating pests or phytopathogenic fungi or bacteria.
  • the compounds may also be mixed with solutions of mineral matters used to remedy nutritional or trace element deficiencies. It may also be advantaeous to apply the compounds according to the invention (either on their own or in possible combinations) in admixture with solid or liquid mineral fertilizers.

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  • Life Sciences & Earth Sciences (AREA)
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  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

4H-3,1-Benzoxazine derivatives of the formula ##STR1## where R1, R2 and Y have the meanings given in the specification, and their use for controlling unwanted plant growth in numerous crops, such as cereals, Indian corn, soybeans and cotton.

Description

The present invention relates to 4H-3,1-benzoxazine derivatives, herbicides containing these compounds as active ingredients, and a process for controlling undesired plant growth with these compounds.
Substituted 4H-3,1-benzoxazin-4-ones are known as intermediates for the synthesis of drugs (German Laid-Open Applications DOS Nos. 1,670,375 and 3,556,590) and as herbicidal active ingredients; in particular, 4H-3,1-benzoxazin-4-ones which carry an unsubstituted or substituted phenyl radical in the 2-position are herbicidally active (Belgian Pat. No. 648,259 and U.S. Pat. Nos. 3,970,652 and 3,914,121). The known compounds are well tolerated by a number of crops, eg. species of grain, rice, Indian corn and sorghum. Their shortcomings reside in a narrow spectrum of action on broad-leaved weeds. Furthermore, even in the case of plants which these benzoxazines control effectively, relatively large amounts per unit area must be used.
We have found that 4H-3,1-benzoxazine derivatives of the formula I ##STR2## where Y is oxygen or sulfur,
R1 is hydrogen, halogen, nitro, alkyl, haloalkyl, haloalkoxy or haloalkylmercapto, each of 1 to 4 carbon atoms, cyano, thiocyano, CO2 R3, ##STR3## Y'R4, SOR4, SO2 R4, SO2 OR4, ##STR4## or CO--R4, where R3 is alkyl or alkenyl of up to 4 carbon atoms,
R4 is alkyl of 1 to 4 carbon atoms,
R5 is hydrogen or alkyl of 1 to 4 carbon atoms,
Y' is oxygen or sulfur and
R2 is a cycloaliphatic or bicycloaliphatic radical of 3 to 10 carbon atoms which is monosubstituted or polysubstituted by methyl, or is a pyrimidine, pyrazine, pyridazine, triazine, thiazole, isothiazole, pyrazole, imidazole, triazole, oxazole or isoxazole radical which is unsubstituted or is monosubstituted or polysubstituted by methyl and/or halogen, or is a furan, morpholine or pyridine radical which is monosubstituted or polysubstituted by methyl and/or halogen, and, if R1 is hydrogen, R2 may also be an m-substituted or p-substituted, or m- and p-substituted, aryl radical of the formula Ar(R6)n, where Ar is phenyl and R6 is alkylmercapto, haloalkoxy, haloalkylmercapto, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl or haloalkylsulfonyl, each of 1 to 4 carbon atoms, ##STR5## alkoxycarbonyl, alkenyloxycarbonyl, alkylmercaptocarbonyl or alkenylmercaptocarbonyl, each with alkyl or alkenyl of 1 to 4 carbon atoms, NH--CO--NH--CH3, NH--CO--N(CH3)2, ##STR6## formamido, alkoxycarbamyl, alkenyloxycarbamyl, alkylmercaptocarbamyl, alkenylmercaptocarbamyl, alkylmercaptodithiocarbamyl, alkenylmercaptodithiocarbamyl, alkylcarbamido, dialkylcarbamido, alkenylcarbamido, dialkenylcarbamido, alkylsulfamyl, dialkylsulfamyl, alkylsulfonamido or haloalkylsulfonamido, each with alkyl or alkenyl of 1 to 4 carbon atoms, or formyl, and n is 1 or 2, and if R1 does not denote hydrogen or halogen. R6 may also denote hydrogen, halogen, cyano, thiocyano, nitro, haloalkyl of 1 to 4 carbon atoms or acyl of 2 to 5 carbon atoms, and if R1 denotes fluorine or hydrogen and n is 2, R6 may also denote hydrogen, fluorine, chlorine, nitro or alkoxycarbonyl of 2 to 5 carbon atoms, and if R1 denotes halogen and n is 1, R6 may also denote haloalkoxy, haloalkylmercapto or alkylsulfinyl, and if R1 denotes hydrogen, R2 may also be aralkyl substituted in the m-position or p-position or m- and p-position, by haloalkyl or haloalkoxy, each of 1 to 4 carbon atoms, are excellently tolerated by crop plants and exhibit a substantially more powerful herbicidal action than the benzoxazines hitherto disclosed.
In formula I, R1 is, for example, hydrogen, fluorine, chlorine, bromine, iodine, nitro, methyl, ethyl, isopropyl, n-propyl, n-butyl, isobutyl, tert.-butyl, trichloromethyl, difluorochloromethyl, trifluoromethyl, difluoromethyl, 2,2,1,1-tetrafluoroethyl, trifluoromethoxy, hexafluoroisopropoxy, difluoromethylmercapto, trifluoromethylmercapto, a radical of the formula Y"CF2 C(Z)3, where Y" is oxygen or sulfur and each Z independently may be hydrogen, fluorine, chlorine, bromine or iodine, eg. 2,2,1,1-tetrafluoroethoxy, 1,1-difluoroethoxy, 2,2,1,1-tetrafluoroethylmercapto and 1,1-difluoroethylmercapto, cyano, thiocyano, CO2 CH3, CO2 C2 H5, CO2 --CH(CH3)2, CO2 --CH2 --CH═CH2, CO--N(CH3)2, CO--N(C2 H5)2, methoxy, ethoxy, n-butoxy, isobutoxy, methylthio, ethylthio, n-propylthio, sec.-butylthio, SOCH3, SOC2 H5, SO2 CH3, SO2 C2 H5, SO2 C3 H7, SO2 OCH3, SO2 OC2 H5, SO2 OC4 H9, SO2 --NHCH3, SO2 --N(CH3)2, SO2 --N(C2 H5).sub. 2, formyl, acetyl and propionyl.
R2 in formula I is, for example, cyclopentyl, cyclohexyl, α- , β- or γ-methylcyclopentyl, α- , β- or γ-methylcyclohexyl, 1,4-methano-bicyclo-(4,3)-nonane, 2-methyl-fur-3-yl, 3-methyl-fur-2-yl, 4-methyl-fur-2-yl, 5-methyl-fur-2-yl, 2-methyl-fur-4-yl, 3-methyl-fur-4-yl, 2,5-dimethyl-fur-4-yl, 4-methyl-pyrid-2-yl, 5-methyl-pyrid-2-yl, 2-methyl-pyrid-4-yl, 2-methyl-pyrid-5-yl, 3-chloro-pyrid-5-yl, 2-chloro-pyrid-4-yl, 2-chloro-pyrid-5-yl, pyrimidin-2-yl, -4-yl, -5-yl or -6-yl, 4-methylpyrimidin-2-yl, 4-chloropyrimidin-2-yl, pyridazin-3, -4-, -5- or -6-yl, imidazol-1-, -2-, -4- or -5-yl, 5-methylimidazol-2-yl, 2-methyl-imidazol-5-yl, oxazol-2-, -4- or -5-yl, 2-methyl-oxazol-5-yl, isoxazol-3-, -4- or -5-yl, 3-methyl-isoxazol-5-yl, 3-chloro-isoxazol-5-yl, 1,2,4-triazol-1-yl, 1,2,5-triazin-3-yl, 1,2,5-triazin-4-yl, 1,2,4-triazol-3-yl, 1,2,4-triazolyl-5-yl, α-pyrazinyl or aryl, especially phenyl which may be substituted by the following in the m-position, p-position or m- and p-position: methylmercapto, ethylmercapto, isopropylmercapto, chloromethoxy, fluoromethoxy, difluoromethoxy, difluorochloromethoxy, trifluoromethoxy, trichloromethoxy, 1,1,2,2-tetrafluoroethoxy, 1,1,2-trifluoro-2-chloroethoxy, 1,1,1-trifluoro-2-bromoethoxy, 1,1,2,3,3,3-hexafluoro-n-propyloxy, pentafluoroethoxy, hexafluoroisopropoxy, difluoromethylmercapto, trifluoromethylmercapto, pentafluoroethylmercapto, 1,1,2,2-tetrafluoroethylmercapto, trichloromethylmercapto, dichlorofluoromethylmercapto, trifluoromethylmercapto, CH3 SO2, C2 H.sub. 5 SO2, i--C3 H7 SO2, ClCH2 SO2, F2 CHSO2, CF2 SO2, CF3 CF2 SO2, ##STR7## CO2 CH3, CO2 C2 H5, CO2 --i--C3 H7, CO2 --n--C4 H9, CO2 --CH2 CH═CH2, CO--SCH3, CO--SC2 H5, CO--S--i--C3 H7, CO--S--CH2 --CH═CH2, NH--CO--NHCH3, NH--CO--N(CH3)2, ##STR8## NH--CHO, NH--COOCH3, NH--COOC2 H5, NH--COO--i--C3 H7, NH--COO--sec--C4 H9, NH--COOCH2 --CH═CH2, NH--CO--SCH3, NH--CO--SC2 H5, NH--CO--S--i--C3 H7, NH--CO--S--CH2 --CH═CH2, NH--CS--SCH3, NH--CS--SC2 H5, NH--CS--S--i--C3 H7, NH--C--S--S--CH2 --CH═CH2, CO--NHCH3, CO--NHC2 H5, CO--NH--i--C3 H7, CO--N--H--sec--C4 H9, CO--NH--CH2 --CH═CH2, CO--N(CH3)2, CO--N(C2 H5)2, CO--N(i--C3 H7)2, CO--N(CH2 --CH═CH2)2, SO2 --NHCH3, SO2 --NHC2 H5, SO2 --NH(i--C3 H7), SO2 --N(CH3)2 , SO2 --N(C2 H5)2, NH--SO2 --CH3, NH--SO2 --C2 H5, NH--SO2 --CF3, NH--SO2 --NHCH3, NH--SO2 --NHC2 H5, CHO, fluorine, chlorine, bromine, iodine, cyano, thiocyano, nitro, acetyl, propionyl, trifluoromethyl, difluorochloromethyl, difluoromethyl or 1,1,2,2-tetrafluoroethyl, or aralkyl, eg. benzyl, which may be substituted in the m-position or p-position or m- and p-position, for example by trifluoromethyl or trifluoromethoxy.
Preferred compounds of the formula I are those where R1 is hydrogen, R2 is substituted phenyl, R6 is haloalkoxy, haloalkylmercapto or alkylsulfinyl, each of 1 to 4 carbon atoms, and n is 1, or where R1 is halogen, R2 is substituted phenyl, R6 is haloalkoxy, haloalkylmercapto or alkylsulfinyl, each of 1 to 4 carbon atoms, and n is 1, those where R1 is hydrogen, R2 is substituted phenyl, R6 is halogen, haloalkoxy, haloalkylmercapto or alkylsulfinyl, each of 1 to 4 carbon atoms, and n is 2, or those where R1 is fluorine, R2 is unsubstituted or substituted phenyl, R6 is hydrogen or halogen and n is 2.
Further, we have found that benzoxazine derivatives of the formula I are obtained if an unsubstituted or substituted anthranilic acid of the formula II ##STR9## where R1 and Y have the above meanings, is reacted with a twofold or even higher molar excess of a carboxylic acid halide of the formula III ##STR10## where R2 has the above meanings and Hal is halogen, especially fluorine, chlorine or bromine, in an aromatic tertiary amine as the solvent, at from 10° to 60° C.
If 3-nitro-4-chloro-benzoyl chloride and anthanilic acid are used as starting materials, the course of the reaction may be represented by the following equation: ##STR11##
Advantageously, a twofold molar excess of the carboxylic acid halide of the formula III is run into a solution of the unsubstituted or substituted anthranilic acid of the formula II in from 5 to 25 moles of an aromatic amine per mole of anthranilic acid, at from 10° to 60° C., after which stirring is continued for 30 minutes at 25° C. (cf. J. Chem. Soc. (C) (1968), 1593). The batch can then be worked up by stirring ice-water into the mixture and filtering off the precipitate which forms. Alternatively, it is possible to carry out the reaction by first taking the carboxylic acid halide and adding the anthranilic acid of the formula II.
Examples of suitable aromatic tertiary amines are pyridine, α, β- and γ-picoline, lutidine, quinoline and acridine.
The benzoxazine derivatives of the formula I may also be obtained by reacting an unsubstituted or substituted anthranilic acid of the formula II ##STR12## where R1 and Y have the above meanings, or an alkali metal salt or alkaline earth metal salt of this anthranilic acid, with about the stoichiometric amount of carboxylic acid halide of the formula III ##STR13## where R2 has the meanings given in claim 1 and Hal is halogen, in an inert organic solvent or in water, in the presence or absence of an acid acceptor, at from 0° to 60° C., to give a carboxylic acid amide of the formula IV ##STR14## where R1, R2 and Y have the above meanings, and then cyclizing this amide at from 30° to 150° C. in the presence of a dehydrating agent.
If 2,5-dimethylfuran-3-carboxylic acid chloride and anthranilic acid are used as the starting materials, the course of the reaction can be represented by the following equations: ##STR15##
Examples of suitable inert solvents are hydrocarbons, eg. naphtha, gasoline, toluene, pentane, hexane, cyclohexane and petroleum ether, halohydrocarbons, eg. methylene chloride, chloroform, carbon tetrachloride, 1,1- and 1,2-dichloroethane, 1,1,1- and 1,1,2-trichloroethane, chlorobenzene, o-, m- and p-dichlorobenzene and o-, m- and p-chlorotoluene, nitrohydrocarbons, eg. nitrobenzene, nitroethane and o-, m- and p-chloronitrobenzene, nitriles, eg. acetonitrile, butyronitrile and isobutyronitrile, ethers, eg. diethyl ether, di-n-propyl ether, tetrahydrofuran and dioxane, esters, eg. ethyl acetoacetate, ethyl acetate and isobutyl acetate, and amides, eg. formamide, methylformamide and dimethylformamide.
Any of the conventional acid-binding agents may be used as the acid acceptor. Amongst these, alkali metal hydroxides, alkali metal carbonates and tertiary organic bases are preferred. Specific examples of particularly suitable compounds are sodium hydroxide, sodium carbonate, sodium bicarbonate, triethylamine, pyridine, trimethylamine, α-, β- and γ-picoline, lutidine, N,N-dimethylaniline, N,N-dimethylcyclohexylamine, quinoline, tri-n-propylamine and tri-n-butylamine. Advantageously, the acid acceptor is employed in an amount equivalent to the carboxylic acid halide of the formula III.
Suitable dehydrating agents are symmetrical and mixed carboxylic acid anhydrides, eg. acetic anhydride, propionic anhydride, butyric anhydride, formic-acetic anhydride, formic-propionic anhydride and acetic-propionic anhydride, as well as dicyclohexylcarbodiimide and thionyl chloride. The cyclization is carried out with from 1 to 10 moles of dehydrating agent per mole of carboxylic acid amide of the formula IV.
The starting materials of the formulae II and III are employed in about the stoichiometric ratio, ie. to within ±10% of this ratio.
Advantageously, the process is carried out by adding the carboxylic acid halide of the formula III and the equivalent amount of acid acceptor from two separate feeds, at from 0° to 60° C., to an about equivalent amount of the anthranilic acid of the formula III, or a salt thereof, in an inert organic solvent or in water. The mixture is then stirred for 15 minutes at room temperature after which it is concentrated if necessary, acidified, whilst warm, with 5 N hydrochloric acid, cooled and filtered (J. Org. Chem. 2 (1944) 396), giving a N-acyl-2-aminobenzoic acid. This can be cyclized to the required 4H-3,1-benzoxazine in the presence of a 5- to 10-fold amount of acetic anhydride by stirring under reflux, with or without distillation of the acetic acid formed. To work up the mixture, excess acetic anhydride is removed on a rotary evaporator under reduced pressure and, if necessary, the product is purified by recrystallization. The carboxylic acid halide may also be introduced first into the receiver instead of the anthranilic acid.
Instead of using acetic anhydride, the cyclization can also be carried out with from 1 to 4 moles of dicyclohexylcarbodiimide or thionyl chloride per mole of N-acyl-2-aminobenzoic acid, at 30°-150° C.
In the case of reactive substituents R6, for example a carbamic acid ester group, it is advantageous first to prepare a nitro-substituted intermediate and then to react this, after reduction, with an acylating agent, for example as shown in the following equations: ##STR16##
However, it is also possible first to prepare a nitro-substituted 2-phenyl-3,1-benzoxazin-4-one, reduce this, convert the product into a reactive isocyanate by means of phosgene and then subject the latter to reactions with nucleophilic reactants, eg. amines, mercaptans or alcohols. ##STR17##
It is also possible to react an amino-substituted 2-phenyl-3,1-benzoxazin-4-one with an acylating reagent, eg. a carboxylic acid or sulfonic acid anhydride or chloride, in accordance with the following equations: ##STR18##
In the case of fluoroalkoxy-substituted or fluoroalkylmercapto-substituted 2-phenyl-3,1-benzoxazin-4-ones, it is advantageous to convert a fluoroalkoxy-substituted or fluoroalkylmercapto-substituted benzoic acid, by conventional methods, into the corresponding acid chloride (Houben-Weyl, Methoden der organischen Chemie, 8, 463 et seq., 4th edition, Georg-Thieme-Verlag, Stuttgart, 1952) and then convert the acid chloride, by means of an unsubstituted or substituted anthranilic acid, into the corresponding amide by a conventional method. The amide is then converted to the substituted 2-phenyl-3,1-benzoxazin-4-one by cyclization in the presence of a dehydrating agent.
To isolate the 4H-3,1-benzoxazine derivatives of the formula I from the reaction mixture, the latter may be treated with water, dilute alkali or dilute acid to separate out by-products, such as unconverted anthranilic acid, acid chloride or base hydrochloric, and may then be dried and concentrated. Where necessary, the end products can be purified by recrystallization or chromatography.
The following are examples of the preparation of carboxylic acid halides of the formula III to serve as intermediates for 4H-3,1-benzoxazin-4-ones:
3-Chloro-4-chlorodifluoromethoxybenzoyl fluoride
3-Chloro-4-methoxybenzoic acid is converted by means of thionyl chloride, by a conventional method, to 3-chloro-4-methoxybenzoyl chloride of boiling point 106° C./0.13 mbar and melting point 45°-50° C.
Chlorination of a mixture of 166 parts by weight of 3-chloro-4-methoxybenzoyl chloride and 10 parts by weight of phosphorus pentachloride for 7 hours at 195°-205° C. gives 208 parts by weight of 3-chloro-4-trichloromethoxybenzoyl chloride of boiling point 114° C./0.13 mbar and nD 25 =1.5780.
105 Parts by weight of 3-chloro-4-trichloromethoxybenzoyl chloride are introduced over 5 minutes into 92 parts by weight of antimony trifluoride at 90° C., whilst stirring, and the mixture is then stirred for 15 minutes at 110°-120° C. Distillation under reduced pressure gives 39.5 parts by weight of 3-chloro-4-chlorodifluoromethoxybenzoyl fluoride of boiling point 96°-105° C./13 mbar and nD 22 =1.5185.
3-Chloro-4-trifluoromethoxybenzoyl fluoride
64 Parts by weight of 3-chloro-4-trichloromethoxybenzoyl chloride are introduced over 6 minutes into a mixture of 1.1 parts by weight of antimony pentachloride and 70 parts by weight of antimony trifluoride at 90° C., while stirring. The reaction mixture is stirred for 20 minutes at 190° C. and is then distilled under reduced pressure, giving 25 parts by weight of 3-chloro-4-trifluoromethoxybenzoyl fluoride, of nD 25 =1.4649.
3-Chlorodifluoromethoxy-4-chloro-benzoyl fluoride
A mixture of 86 parts by weight of 3-methoxy-4-chlorobenzoyl chloride and 5 parts by weight of phosphorus pentachloride is chlorinated for 7 hours at 195°-205° C., giving 112 parts by weight of 3-trichloromethoxy-4-chlorobenzoyl chloride of boiling point 92°-96° C./0.13 mbar.
69 Parts by weight of 3-trichloromethoxy-4-chlorobenzoyl chloride are introduced over 4 minutes into 60 parts by weight of antimony trifluoride at 90° C., whilst stirring, and the mixture is then stirred for 20 minutes at 110° C. Distillation gives 55 parts by weight of 3-chlorodifluoromethoxy-4-chlorobenzoyl fluoride of boiling point 88°-90° C./13 mbar and nD 22 =1.5350.
3-Trifluoromethoxy-4-dichlorobenzoyl fluoride
30.8 Parts by weight of 3-trichloromethoxy-4-chlorobenzoyl chloride are introduced over 3 minutes into a mixture of 35.7 parts by weight of antimony trifluoride and 1 part by weight of antimony pentachloride at 90° C., whilst stirring, and the mixture is then stirred for 20 minutes at 190° C. Subsequent distillation gives 19 parts by weight of 3-trifluoromethoxy-4-chloro-benzoyl fluoride of boiling point 96°-103° C./39 mbar.
3-(1',1',2'-Trifluoro-2'-chloroethoxy)-benzoyl chloride
52.4 Parts by weight of chlorotrifluoroethylene are introduced, over 10 hours, into a mixture of 46.5 parts by weight of methyl 3-hydroxybenzoate and 9.5 parts by weight of potassium hydroxide powder in 50 parts by weight of acetone, refluxing at 45°-52° C. After concentrating the reaction mixture on a rotary evaporator under reduced pressure, the residue is taken up in methylene chloride and the solution is extracted with sodium bicarbonate solution, dried and evaporated, giving 69.5 parts by weight of methyl 3-(1',1',2'-trifluoro-2'-chloroethoxy)-benzoate of nD 25 =1.4710.
40 Parts by weight of methyl 3-(1',1',2'-trifluoro-2'-chloroethoxy)-benzoate, in a mixture of 8.4 parts by weight of potassium hydroxide, 100 parts by weight of water and 5 parts by weight of tetrahydrofuran, are stirred for 15 minutes at 95° C. The resulting solution is acidified with concentrated hydrochloric acid and the precipitate formed is filtered off and dried; 35 parts of 3-(1',1',2'-trifluoro-2'-chloroethoxy)benzoic acid of melting point 79°-85° C. are obtained.
35 Parts by weight of 3-(1',1',2'-trifluoro-2'-chloroethoxy)-benzoic acid are converted to 3-(1',1',2'-trifluoro-2'-chloroethoxy)-benzoyl chloride, of nD 22 =1.4900 (IR: C═O 1,760 and 1,742 cm-1) in a conventional manner by means of 20.2 parts by weight of thionyl chloride and 0.2 part by weight of pyridine as the catalyst. Yield: 34.5 parts by weight, corresponding to 92% of theory.
3,4-Difluorobenzoyl chloride
36 Parts by weight of 3,4-difluorobenzoic acid (J. org. Chem. 27 (1962), 2,923) are converted to the corresponding acid chloride, of boiling point 63°-66° C./10 mbar (IR: C═O 1,752 cm-1) in a conventional manner by means of 59.5 parts by weight of thionyl chloride and 0.2 part by weight of pyridine. Yield: 25 parts by weight of 3,4-difluorobenzoyl chloride.
3-Chloro-4-fluorobenzoyl chloride
100 Parts by weight of 3-chloro-4-fluorobenzoic acid (J. Chem. Soc. 1693, 2784) are converted to the corresponding acid chloride in a conventional manner by means of 83.3 parts by weight of thionyl chloride and 0.2 part by weight of pyridine. Yield: 63.1 parts by weight of 3-chloro-4-fluorobenzoyl chloride, of boiling point 45°-47° C./0.13 mbar.
The Examples which follow illustrate the preparation of some 4H-3,1-benzoxazine derivatives. Parts by weight bear the same relation to parts by volume as that of the kilogram to the liter.
EXAMPLE 1 Preparation of 2-(m-methoxycarbamylphenyl)-3,1-benzoxazin-4-one
3-Nitrobenzoyl chloride and anthranilic acid are converted by a conventional method to 3-nitrobenzoylanthanilic acid, of melting point 242°-247° C. (J. Am. Chem. Soc. 33 (1911), 952).
56 parts by weight of the amide thus obtained, in a mixture of 400 parts by volume of absolute ethanol and 15 parts by weight of Raney nickel, are hydrogenated for 3 hours at 60° C. under a pressure of 100 bar. The reaction mixture is filtered, the filter residue is washed with ethanol, and the filtrates are concentrated under reduced pressure. The residue obtained is taken up in 3 N sodium hydroxide solution and the resulting solution is extracted once with ether and stirred into dilute hydrochloric acid. After filtering off the product, and drying it, 3-aminobenzoylanthranilic acid (melting point 260° C., with decomposition) is obtained.
41 parts by weight of the acid thus obtained and 17.1 parts by weight of triethylamine are dissolved in 700 parts by volume of 1,2-dichloroethane and 16.1 parts by weight of methyl chloroformate are added from a dropping funnel, at 25° C., whilst stirring. After stirring the mixture for 12 hours, the precipitate which has formed is filtered off, washed with water and dried, giving m-methoxycarbamyl-benzoylanthranilic acid of melting point 216°-220° C.
16 parts by weight of the compound thus obtained and 130 parts by volume of acetic anhydride are refluxed for 1 hour, whilst stirring. When the mixture has cooled, the precipitate is filtered off, washed with ether and dried, giving 13 parts by weight of 2-(m-methoxycarbamylphenyl)-3,1-benzoxazin-4-one of melting point 223°-226° C.; yield: 88% of theory.
EXAMPLE 2 Preparation of 2-(m-ethoxycarbamylphenyl)-3,1-benzoxazin-4-one
21 Parts by weight of 2-(m-nitrophenyl)-3,1-benzoxazin-4-one, in a mixture of 160 parts by volume of 1,4-dioxane and 2.5 parts by weight of 5% strength palladium on charcoal, are hydrogenated for 10 hours at 50° C. under a pressure of 20 bar. The catalyst is removed by filtration and the reaction mixture is concentrated under reduced pressure and then stirred with 50 parts by volume of 1 N sodium hydroxide solution, and the precipitated 2-(m-aminophenyl)-3,1-benzoxazin-4-one is washed with water and dried; melting point 150°-154° C.
40 Parts by weight of 2-(m-aminophenyl)-3,1-benzoxazin-4-one are suspended in 300 parts by volume of chlorobenzene and the suspension is treated with hydrogen chloride gas until saturated therewith, and then with phosgene gas for 4 hours at 110° C. The clear solution is concentrated under reduced pressure and the residue is then washed with ether and petroleum ether, giving 39 parts by weight of 2-(m-isocyanatophenyl)-3,1-benzoxazin-4-one of melting point 115°-121° C.
2.4 parts by weight of absolute ethanol and 1 drop of triethylamine as the catalyst are added to a solution of 13.2 parts by weight of 2-(m-isocyanatophenyl)-3,1-benzoxazin-4-one in 150 parts by volume of 1,2-dichloroethane at 25° C., whilst stirring. The reaction mixture is stirred for 2 hours at 50° C. and cooled, and the product is filtered off. After washing the latter with ether and petroleum ether, 2-(m-ethoxycarbamyl-phenyl)-3,1-benzoxazin-4-one is obtained in the form of colorless crystals of melting point 179°-183° C. Yield: 10.5 parts by weight, corresponding to 68% of theory.
EXAMPLE 3 Preparation of 2-(m-1',1',2',2'-tetrafluoroethoxyphenyl)-3,1-benzoxazin-4-one
39.4 parts by weight of thionyl chloride are added to a suspension of 65 parts by weight of m-(1,1,2,2-tetrafluoroethoxy)-benzoic acid in 500 parts by volume of 1,2-dichloroethane and the mixture is stirred for 3 hours under reflux. It is then concentrated under reduced pressure, and after filtering off a small amount of starting material which has precipitated, m-(1,1,2,2-tetrafluoroethoxy)-benzoyl chloride is obtained as a yellowish oil. The IR spectrum shows C═O bands at 1,770 and 1,748 cm-1 and fluoroalkoxy bands at 1,225, 1,190 and 1,125 cm-1.
25.7 Parts by weight of m-(1,1,2,2-tetrafluoroethoxy)-benzoyl chloride and 10.1 parts by weight of triethylamine are added from two separate feeds, over 15 minutes, to a stirred mixture of 13.7 parts by weight of anthranilic acid and 300 parts by volume of 1,2-dichloroethane, and stirring is continued for 12 hours at room temperature. The reaction mixture is extracted with 0.5 N hydrochloric acid and with water, dried over magnesium sulfate and concentrated under reduced pressure. After triturating the product in 0.5 N hydrochloric acid, filtering off and washing with water, m-(1,1,2,2-tetrafluoroethoxy)-benzoylanthranilic acid of melting point 159°-163° C. is obtained.
21 parts by weight of the product thus obtained are cyclized for 3 hours in 200 parts by volume of refluxing acetic anhydride, whilst stirring. The reaction mixture is then concentrated under reduced pressure, the residue is taken up in methylene chloride and the solution is chromatographed over neutral aluminum oxide. After concentrating the eluate, 16 parts by weight of 2-(m-1',1',2',2'-tetrafluoroethoxyphenyl)-3,1-benzoxazin-4-one of melting point 95°-98° C. are obtained.
EXAMPLE 4 Preparation of 2-(m-difluoromethoxy-phenyl)-3,1-benzoxazin-4-one
260 Parts by eight of chlorodifluoromethane are passed, over 1.5 hours, into a stirred mixture of 221 parts by weight of m-cresol, 412 parts by weight of sodium hydroxide, 600 parts by volume of 1,4-dioxane and 500 parts by volume of water, at 67°-70° C. After stirring for 45 minutes at 68° C., the reaction mixture is cooled, diluted with 1,000 parts by volume of water and extracted four times with 200 parts by volume of ether. After drying the ether phase, concentrating under reduced pressure and distilling, 172 parts by weight of m-tolyl difluoromethyl ether of boiling point 64°-67° C./24.7 mbar are obtained.
A mixture of 47.4 parts by weight of m-tolyl difluoromethyl ether, 77 parts by weight of magnesium sulfate, 134.3 parts by weight of potassium permanganate and 1,900 parts by volume of water is stirred for 3 hours at 50°-60° C. for 2 hours at 90° C. After destroying excess permanganate with ethanol, the solution is filtered whilst still hot and the filtrate is then acidified. The precipitate formed is taken up in methylene chloride and the extract is dried; after concentrating under reduced pressure, 3-difluoromethoxybenzoic acid of melting point 85°-87° C. is obtained.
The above acid can be converted by means of thionyl chloride, in a conventional manner, to 3-difluoromethoxybenzoyl chloride of nD 25 =1.5083.
25 parts by weight of 3-difluoromethoxybenzoyl chloride and 12.2 parts by weight of triethylamine are added over 15 minutes, from 2 separate feeds, to a stirred mixture of 16.6 parts by weight of anthranilic acid in 360 parts by weight of 1,2-dichloroethane at 25°-30° C. After stirring for 2 hours at 25° C., the reaction mixture is extracted with 0.5 N hydrochloric acid and with water. The organic phase is then extracted with four times 100 parts of 0.5 N sodium hydroxide solution, and the extracts are stirred into dilute hydrochloric acid. After filtration and drying, 30.4 parts by weight, corresponding to 82% of theory, of N-(3-difluoromethoxybenzoyl)-anthranilic acid of melting point 186°-191° C. are obtained. 8.33 Parts by weight of thionyl chloride are introduced into a stirred mixture of 18 parts by weight of N-(3-difluoromethoxybenzoyl)anthranilic acid in 250 parts by weight of 1,2-dichloroethane at 25° C.; the mixture is then stirred for 4 hours under reflux. When it has cooled, the reaction mixture is extracted with 100 parts by volume of ice-water and 100 parts by volume of 0.5 N sodium hydroxide solution and is chromatographed over neutral aluminum oxide. 12 parts by weight, corresponding to 71% of theory, of 2-(3'-difluoromethoxy-phenyl)-3,1-benzoxazin-4-one, of melting point 84°-87° C., are obtained.
EXAMPLE 5 Preparation of 2-(m-trifluoromethylsulfinyl-phenyl)-3,1-benzoxazin-4-one
8.85 Parts by weight of m-chloroperbenzoic acid in 150 parts of methylene chloride are added to a mixture of 16.2 parts of 2-(m-trifluoromethylmercapto-phenyl)-3,1-benzoxazin-4-one and 130 parts of methylene chloride at room temperature. The mixture is then stirred for a further 22 hours. The precipitate, which has formed is dissolved by adding 100 parts of methylene chloride and the solution obtained is extracted twice with 0.3 N sodium hydroxide solution and with water. It is then dried over magnesium sulfate and chromatographed over aluminum oxide, giving 12.4 parts of 2-(m-trifluoromethylsulfinyl-phenyl)-3,1-benzoxazin-4-one, of melting point 106°-108° C.
EXAMPLE 6 Preparation of 2-(m-trifluoromethylsulfonyl-phenyl)-3,1-benzoxazin-4-one
Following the method described in Example 5, but starting from 17.3 parts of m-chloroperbenzoic acid, 12 parts of 2-(m-trifluoromethylsulfonyl-phenyl)-3,1-benzoxazin-4-one, of melting point 96°-102° C., are obtained.
Using corresponding methods, the following 4-H-3,1-benzoxazine derivatives of the formula I can be prepared:
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 ##STR19##                                                                

__________________________________________________________________________
R.sup.2           Y m.p. [°C.]                                     
                              R.sup.2         Y m.p. [°C.]         
__________________________________________________________________________
 ##STR20##        O                                                       
 ##STR21##        O 120-123                                               
                               ##STR22##      S                           
 ##STR23##        S                                                       
                               ##STR24##      O 145-149                   
 ##STR25##        O                                                       
                               ##STR26##      O 107-110                   
 ##STR27##        O 87-90                                                 
                               ##STR28##      O                           
 ##STR29##        O 94-95                                                 
                               ##STR30##      O 108-112                   
 ##STR31##        O  98-102                                               
                               ##STR32##      S                           
 ##STR33##        O                                                       
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 ##STR35##        O 82-86                                                 
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                               ##STR38##      O 87-90                     
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 ##STR43##        O 146-151                                               
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 ##STR53##        O                                                       
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 ##STR55##        O 200-202                                               
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          Y          R.sup.2     m.p. [°C.]                        
__________________________________________________________________________
          O                                                               
                      ##STR63##  130-134                                  
          O                                                               
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                      ##STR66##  170-173                                  
          O                                                               
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                      ##STR70##  155-158                                  
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                      ##STR72##  177-180                                  
          O                                                               
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                      ##STR76##  149-153                                  
          O                                                               
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                      ##STR78##  188-191                                  
          O                                                               
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                      ##STR84##  174-178                                  
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          O                                                               
                      ##STR87##  152-155                                  
          O                                                               
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          O                                                               
                      ##STR90##  103-106                                  
          O                                                               
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          O                                                               
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          O                                                               
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          O                                                               
                      ##STR94##                                           
          O                                                               
                      ##STR95##  108-111                                  
          O                                                               
                      ##STR96##                                           
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          O          R.sup.2     m.p. [°C.]                        
__________________________________________________________________________
          O                                                               
                      ##STR97##                                           
          S                                                               
                      ##STR98##                                           
          O                                                               
                      ##STR99##                                           
          O                                                               
                      ##STR100##                                          
          O                                                               
                      ##STR101## 157-160                                  
          S                                                               
                      ##STR102##                                          
__________________________________________________________________________
R.sup.2              Y m.p. [°C.]                                  
                            R.sup.2             Y m.p. [°C.]       
__________________________________________________________________________
 ##STR103##          O                                                    
 ##STR104##          O 105-108                                            
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 ##STR123##          O 86-89                                              
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 ##STR125##          O                                                    
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 ##STR170##          O                                                    
                             ##STR171##         O 118-121                 
 ##STR172##          O                                                    
                             ##STR173##         O n.sub.D.sup.25 =        
                                                  1.5669                  
 ##STR174##          O                                                    
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 ##STR176##          O                                                    
                             ##STR177##         O                         
 ##STR178##          O                                                    
                             ##STR179##         O n.sub.D.sup.25 =        
                                                  1.5510                  
 ##STR180##          O                                                    
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 ##STR183##          S                                                    
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 ##STR191##          O 153-157                                            
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 ##STR197##          O 202-205                                            
                             ##STR198##         O 170-173                 
 ##STR199##          S                                                    
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                             ##STR208##         O 198-202                 
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                             ##STR212##         O 93-96                   
 ##STR213##          O 114-116                                            
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                             ##STR216##         O                         
 ##STR217##          O 103-105                                            
                             ##STR218##         O 114-117                 
 ##STR219##          O 79-81                                              
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 ##STR220##                                                               

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R.sup.1   Y      R.sup.2            m.p. [°C.]                     
______________________________________                                    
Br        O      C.sub.6 H.sub.5                                          
SCN       O      C.sub.6 H.sub.5                                          
CN        O      C.sub.6 H.sub.5                                          
Cl        O      C.sub.6 H.sub.5    153-155                               
Cl        S      C.sub.6 H.sub.5                                          
F         O      C.sub.6 H.sub.5    157-161                               
CCl.sub.3 O      C.sub.6 H.sub.5                                          
CF.sub.3  O      C.sub.6 H.sub.5                                          
CF.sub.3  S      C.sub.6 H.sub.5                                          
Cl        O                                                               
                  ##STR221##        124-128                               
 ##STR222##                                                               
          O      C.sub.6 H.sub.5                                          
OCH.sub.3 O      C.sub.6 H.sub.5                                          
SCH.sub.3 O      C.sub.6 H.sub.5                                          
SOCH.sub.3                                                                
          O      C.sub.6 H.sub.5                                          
SO.sub.2 CH.sub.3                                                         
          O      C.sub.6 H.sub.5                                          
NO.sub.2  O      C.sub.6 H.sub.5    180                                   
SO.sub.2 OCH.sub.3                                                        
          O      C.sub.6 H.sub.5                                          
CH.sub.3  O                                                               
                  ##STR223##        125-127                               
SCN       O                                                               
                  ##STR224##                                              
Cl        O                                                               
                  ##STR225##        137-138                               
SO.sub.2 N(CH.sub.3).sub.2                                                
          O                                                               
                  ##STR226##                                              
CH.sub.3  O      C.sub.6 H.sub.5    152-155                               
F         O                                                               
                  ##STR227##         98-100                               
F         O                                                               
                  ##STR228##        92-96                                 
CO.sub.2 CH.sub.3                                                         
          O      C.sub.6 H.sub.5                                          
Cl        S                                                               
                  ##STR229##                                              
Cl        O                                                               
                  ##STR230##        140-143                               
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R.sup.1   O      R.sup.2            m.p. [°C.]                     
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Cl        O                                                               
                  ##STR231##                                              
F         O                                                               
                  ##STR232##        205-208                               
Cl        O                                                               
                  ##STR233##                                              
Cl        O                                                               
                  ##STR234##                                              
Cl        O                                                               
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R.sup.1   Y      R.sup.2            m.p. [°C.]                     
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Cl        O                                                               
                  ##STR236##                                              
F         O                                                               
                  ##STR237##                                              
Cl        O                                                               
                  ##STR238##                                              
F         O                                                               
                  ##STR239##                                              
CH.sub.3  O                                                               
                  ##STR240##                                              
CH.sub.3  O                                                               
                  ##STR241##                                              
CH.sub.3  O                                                               
                  ##STR242##                                              
CH.sub.3  O                                                               
                  ##STR243##                                              
CH.sub.3  O                                                               
                  ##STR244##                                              
CH.sub.3  O                                                               
                  ##STR245##                                              
CH.sub.3  O                                                               
                  ##STR246##                                              
CN        O                                                               
                  ##STR247##                                              
CN        O                                                               
                  ##STR248##                                              
F         O                                                               
                  ##STR249##        93-97                                 
Cl        O                                                               
                  ##STR250##        125-129                               
F         O                                                               
                  ##STR251##        102-104                               
Cl        O                                                               
                  ##STR252##        112-116                               
Cl        O                                                               
                  ##STR253##        115-116                               
NO.sub.2  O                                                               
                  ##STR254##        154-152                               
Cl        O                                                               
                  ##STR255##        168-171                               
Cl        O                                                               
                  ##STR256##                                              
CN        O                                                               
                  ##STR257##                                              
CN        O                                                               
                  ##STR258##                                              
CN        O                                                               
                  ##STR259##                                              
NO.sub.2  O                                                               
                  ##STR260##                                              
NO.sub.2  O                                                               
                  ##STR261##                                              
______________________________________
The active ingredients according to the invention may be applied for instance in the form of directly sprayable solutions, powders, suspensions (including high-percentage aqueous, oily or other suspensions), dispersions, emulsions, oil dispersions, pastes, dusts, broadcasting agents, or granules by spraying, atomizing, dusting, broadcasting or watering. The forms of application depend entirely on the purpose for which the agents are being used; in any case they should ensure as fine a distribution of active ingredient as possible.
For the preparation of solutions, emulsions, pastes and oil dispersions to be sprayed direct, mineral oil fractions of medium to high boiling point, such as kerosene or diesel oil, further coal-tar oils, and oils of vegetable or animal origin, aliphatic, cyclic and aromatic hydrocarbons such as benzene, toluene, xylene, paraffin, tetrahydronaphthalene, alkylated naphthalenes and their derivatives such as methanol, ethanol, propanol, butanol, chloroform, carbon tetrachloride, cyclohexanol, cyclohexanone, chlorobenzene, isophorone, etc., and strongly polar solvents such as dimethylformamide, dimethylsulfoxide, N-methylpyrrolidone, water, etc. are suitable.
Aqueous formulations may be prepared from emulsion concentrates, pastes, oil dispersions or wettable powders by adding water. To prepare emulsions, pastes and oil dispersions the ingredients as such or dissolved in an oil or solvent may be homogenized in water by means of wetting or dispersing agents, adherents or emulsifiers. Concentrates which are suitable for dilution with water may be prepared from active ingredient, wetting agent, adherent, emulsifying or dispersing agent and possibly solvent or oil.
Examples of surfactants are: alkali metal, alkaline earth metal and ammonium salts of ligninsulfonic acid, naphthalenesulfonic acids, phenolsulfonic acids, alkylaryl sulfonates, alkyl sulfates, and alkyl sulfonates, alkali metal and alkaline earth metal salts of dibutylnaphthalenesulfonic acid, lauryl ether sulfate, fatty alcohol sulfates, alkali metal and alkaline earth metal salts of fatty acids; salts of sulfated hexadecanols, heptadecanols, and octadecanols, salts of sulfated fatty alcohol glycol ethers, condensation products of sulfonated naphthalene and naphthalene derivatives with formaldehyde, condensation products of naphthalene or naphthalenesulfonic acids with phenol and formaldehyde, polyoxyethylene octylphenol ethers, ethoxylated isooctylphenol, ethoxylated octylphenol and ethoxylated nonylphenol, alkylphenol polyglycol ethers, tributylphenyl polyglycol ethers, alkylaryl polyether alcohols, isotridecyl alcohol, fatty alcohol ethylene oxide condensates, ethoxylated castor oil, polyoxyethylene alkyl ethers, ethoxylated polyoxypropylene, lauryl alcohol polyglycol ether acetal, sorbitol esters, lignin, sulfite waste liquors and methyl cellulose.
Powders, dusts and broadcasting agents may be prepared by mixing or grinding the active ingredients with a solid carrier.
Granules, e.g., coated, impregnated or homogeneous granules, may be prepared by bonding the active ingredients to solid carriers. Examples of solid carriers are mineral earths such as silicic acid, silica gels, silicates, talc, kaolin, Attaclay, limestone, lime, chalk, bole, loess, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, ground plastics, fertilizers such as ammonium sulfate, ammonium phosphate, ammonium nitrate, and ureas, and vegetable products such as grain flours, bark meal, wood meal, and nutshell meal, cellulosic powders, etc.
The formulations contain from 0.1 to 95, and preferably 0.5 to 90, % by weight of active ingredient.
Examples of formulations are as follows.
I. 90 Parts by weight of the compound of Example 1 is mixed with 10 parts by weight of N-methyl-α-pyrrolidone. A mixture is obtained which is suitable for application in the form of very fine drops.
II. 20 Parts by weight of the compound of Example 2 is dissolved in a mixture consisting of 80 parts by weight of xylene, 10 parts by weight of the adduct of 8 to 10 moles of ethylene oxide with 1 mole of oleic acid-N-monoethanolamide, 5 parts by weight of the calcium salt of dodecylbenzenesulfonic acid, and 5 parts by weight of the adduct of 40 moles of ethylene oxide with 1 mole of castor oil. By pouring the solution into 100,000 parts by weight of water and uniformly distributing it therein, an aqueous dispersion is obtained containing 0.02% by weight of the active ingredient.
III. 20 Parts by weight of the compound of Example 3 is dissolved in a mixture consisting of 40 parts by weight of cyclohexanone, 30 parts by weight of isobutanol, 20 parts by weight of the adduct of 7 moles of ethylene oxide with 1 mole of isooctylphenol, and 10 parts by weight of the adduct of 40 moles of ethylene oxide with 1 mole of castor oil. By pouring the solution into 100,000 parts by weight of water and finely distributing it therein, an aqueous dispersion is obtained containing 0.02% by weight of the active ingredient.
IV. 20 Parts by weight of the compound of Example 4 is dissolved in a mixture consisting of 25 parts by weight of cyclohexanol, 65 parts by weight of a mineral oil fraction having a boiling point between 210° and 280° C., and 10 parts by weight of the adduct of 40 moles of ethylene oxide with 1 mole of castor oil. By pouring the solution into 100,000 parts by weight of water and uniformly distributing it therein, an aqueous dispersion is obtained containing 0.02% by weight of the active ingredient
V. 20 Parts by weight of the compound of Example 2 is well mixed with 3 parts by weight of the sodium salt of diisobutylnaphthalene-α-sulfonic acid, 17 parts by weight of the sodium salt of a lignin-sulfonic acid obtained from a sulfite waste liquor, and 60 parts by weight of powdered silica gel, and triturated in a hammer mill. By uniformly distributing the mixture in 20,000 parts by weight of water, a spray liquor is obtained containing 0.1% by weight of the active ingredient.
VI. 3 Parts by weight of the compound of Example 1 is intimately mixed with 97 parts by weight of particulate kaolin. A dust is obtained containing 3% by weight of the active ingredient.
VII. 30 Parts by weight of the compound of Example 2 is intimately mixed with a mixture consisting of 92 parts by weight of powdered silica gel and 8 parts by weight of paraffin oil which has been sprayed onto the surface of this silica gel. A formulation of the active ingredient is obtained having good adherence.
VIII. 20 Parts of the compound of Example 3 is intimately mixed with 2 parts of the calcium salt of dodecylbenzenesulfonic acid, 8 parts of a fatty alcohol polyglycol ether, 2 parts of the sodium salt of a phenolsulfonic acid-urea-formaldehyde condensate and 68 parts of a paraffinic mineral oil. A stable oily dispersion is obtained.
The influence of various representatives of 4H-3,1-benzoxazine derivatives of the formula I on the growth of unwanted plants is demonstrated in greenhouse experiments.
The vessels employed were plastic flowerpots having a volume of 300 cm3, and which were filled with a sandy loam containing about 1.5% humus. The seeds of the test plants (cf. Table 1) were sown shallow, and separately, according to species, or pregerminated young plants or cuttings were transplanted. Generally, the plants were grown to a height of 3 to 10 cm, depending on the growth shape, before being treated. The compounds were emulsified or suspended in water as vehicle, and sprayed through finely distributing nozzles onto the shoot parts of the plants and the soil not completely covered by plants. The pots were set up in the greenhouse--species from warmer areas at from 20° to 30° C., and species from moderate climates at 10° to 20° C. The experiments were run for from 2 to 4 weeks. During this period, the plants were tended and their reactions to the various treatments assessed. The scale used for assessment was 0 to 100, 0 denoting no damage or normal emergence, and 100 denoting nonemergence or complete destruction of at least the visible plant parts.
The plant species used in the experiments are listed in Table 1.
The results given in the tables below show that the 4H-3,1-benzoxazine derivatives of the formula I have a better herbicidal action than prior art herbicidal benzoxazines, and are well tolerated by a number of crop plants. The compounds according to the invention are predominantly applied after emergence of the unwanted plants, either on cropland or uncropped land.
If the crop plants tolerate the active ingredients less well, application techniques may be used in which the agents are sprayed from suitable equipment in such a manner that the leaves of sensitive crop plants are if possible not touched, and the agents reach the soil or the unwanted plants growing beneath the crop plants (post-directed, lay-bytreatment).
              TABLE 1                                                     
______________________________________                                    
List of plant names                                                       
Botanical name Abbreviation in tables                                     
                              Common name                                 
______________________________________                                    
Acanthospermum hispidum                                                   
               Acanthosp. hisp.                                           
                              bristly starbur                             
Arachis hypogaea              peanuts                                     
                              (groundnuts)                                
Avena sativa                  oats                                        
Beta vulgaris  Beta vulg.     sugarbeets                                  
Centaurea spp.                knapweed                                    
Chenopodium album                                                         
               Chenopod. album                                            
                              lambsquarters                               
                              (goosefoot)                                 
Chrysanthemum segetum                                                     
               Chrysanth. segetum                                         
                              corn marigold                               
Cyperus spp.                  nutsedge                                    
Datura stramonium                                                         
               Datura stram   Jimsonweed                                  
Desmodium tortuosum                                                       
               Desmod. tort.  Florida                                     
                              beggarweed                                  
Euphorbia geniculata                                                      
               Euphorb. genic.                                            
                              wild poinsettia                             
Glycine max                   soybeans                                    
Galeopsis spp.                hemp-nettle                                 
Gossypium hirsutum                                                        
               Gossyp. hirs.  cotton                                      
Hordeum vulgare               barley                                      
Matricaria spp.                                                           
               Matric. spp.   chamomile                                   
Malva neglecta                common                                      
                              mallow                                      
Mercurialis annua                                                         
               Mercurial annua                                            
                              annual                                      
                              mercury                                     
Oryza sativa                  rice                                        
Sesbania exaltata             hemp sesbania                               
                              (coffeeweed)                                
Solanum nigrum Solan nigr.    black                                       
                              nightshade                                  
Sorghum bicolor               sorghum                                     
Triticum aestivum             wheat                                       
Xanthium pensylvanicum                                                    
               Xanthium pens. common                                      
                              cocklebur                                   
Zea mays                      Indian corn                                 
______________________________________                                    

                                  TABLE 2                                 
__________________________________________________________________________
Selective herbicidal action of new compounds; postemergence treatment in  
the greenhouse                                                            
 ##STR262##                                                               
              Crop plants - damage in % at appln. rate                    
              of 1.0 kg/ha                                                
              Hordeum                                                     
                   Oryza                                                  
                       Sorghum                                            
                            Triticum  Index of herbicidal action          
R.sup.1                                                                   
  R.sup.2     vulgare                                                     
                   sativa                                                 
                       bicolor                                            
                            aestivum                                      
                                 Zea mays                                 
                                      at appln. rate of 0.5               
__________________________________________________________________________
                                      kg/ha.sup.x                         
   ##STR263## 0    2   0    10   17   87                                  
H                                                                         
   ##STR264## 0    0   0     0    9   90                                  
H                                                                         
   ##STR265## 0    5   30   23   18   58                                  
__________________________________________________________________________
 0 = damage                                                               
 100 =  plants destroyed                                                  
 .sup.x calculated from average values obtained with the following plants:
 Chenopodium album, Cyperus spp., Chrysanthemum segetum, Datura stramonium
 Matricaria spp., Mercurialis annua, Sesbania exaltata and Solanum nigrum 

                                  TABLE 3                                 
__________________________________________________________________________
Selective control of weeds in groundnuts and other crops; postemergence   
treatment in the greenhouse                                               
 ##STR266##                                                               
                  Test plants and % damage                                
            Appln. rate                                                   
                  Arachis                                                 
                       Glycine                                            
                           Oryza                                          
                               Sorghum                                    
                                    Zea                                   
                                       Sesbania                           
                                            Xanthium                      
R.sup.1                                                                   
  R.sup.2   [kg/ha]                                                       
                   hypogaea                                               
                       max sativa                                         
                               bicolor                                    
                                    mays                                  
                                       exaltata                           
                                            pensylvanicum                 
__________________________________________________________________________
Cl                                                                        
   ##STR267##                                                             
            1.0   0    0   5   0    0  82   100                           
   ##STR268##                                                             
            1.0   0    7   6   0    6  81    30                           
__________________________________________________________________________
 0 = no damage                                                            
 100 = plants destroyed                                                   

                                  TABLE 4                                 
__________________________________________________________________________
Selective control of important broadleaved weeds in soybeans;             
postemergence treatment in the greenhouse                                 
 ##STR269##                                                               
                Test plants and % damage                                  
          Appln. rate                                                     
                Glycine                                                   
                    Chenopod.                                             
                          Datura                                          
                              Euphorbia                                   
                                    Solanum                               
                                         Xanthium                         
R.sup.2   [kg/ha]                                                         
                 max                                                      
                    album stram.                                          
                              geniculata                                  
                                    nigrum                                
                                         pens.                            
__________________________________________________________________________
 ##STR270##                                                               
          0.5   12  99    100 92    100  100                              
 ##STR271##                                                               
          0.5    8  70    100 99    100  100                              
 ##STR272##                                                               
          0.5   21  89     87 17     97   90                              
__________________________________________________________________________
 0 = no damage                                                            
 100 = plants destroyed                                                   

              TABLE 5                                                     
______________________________________                                    
Selective control of Galeopsis spp; postemergence treatment               
in the greenhouse                                                         
 ##STR273##                                                               
                Test plants and % damage                                  
                Appln. rate                                               
                          Hordeum                                         
                                 Triticum                                 
                                        Galeopsis                         
R.sup.1                                                                   
    R.sup.2     [kg/ha]   vulgare                                         
                                 aestivum                                 
                                        spp.                              
______________________________________                                    
     ##STR274## 0.5 1.0   0 0    10 10  90 94                             
H                                                                         
     ##STR275## 0.5 1.0   0 0    20 23  30 40                             
(prior art)                                                               
______________________________________                                    

              TABLE 6                                                     
______________________________________                                    
Selective herbicidal action of 4H3,1-benzoxacine derivatives;             
postemergence treatment in the greenhouse                                 
 ##STR276##                                                               
                    Test plants                                           
                    and % damage                                          
                   Appln. rate                                            
                              Avena Centaurea                             
R.sup.1                                                                   
    R.sup.2        [kg/ha]    sativa                                      
                                    spp.                                  
______________________________________                                    
     ##STR277##    3.0         0    100                                   
Cl                                                                        
     ##STR278##    3.0         0    100                                   
Cl                                                                        
     ##STR279##    3.0         0    100                                   
H                                                                         
     ##STR280##    3.0        20     70                                   
H                                                                         
     ##STR281##    3.0        40    100                                   
H                                                                         
     ##STR282##    3.0        80     90                                   
H                                                                         
     ##STR283##    3.0         0    100                                   
H                                                                         
     ##STR284##    3.0        40     90                                   
H                                                                         
     ##STR285##    3.0        80    100                                   
H                                                                         
     ##STR286##    3.0         0     80                                   
______________________________________                                    

                                  TABLE 7                                 
__________________________________________________________________________
Control of broadleaved weeds in cereals; postemergence treatment in the   
greenhouse                                                                
 ##STR287##                                                               
          Test plants and % damage                                        
    Appln. rate                                                           
          Hordeum                                                         
               Oryza                                                      
                   Triticum                                               
                        Chenopod.                                         
                              Chrysanth.                                  
                                    Matricaria                            
                                          Mercurialis                     
R.sup.1                                                                   
    [kg/ha]                                                               
           vulgare                                                        
               sativa                                                     
                   aestivum                                               
                        album segetum                                     
                                    spp.  annua                           
__________________________________________________________________________
F   1.0   0    0   0    90    100   99    98                              
Cl  1.0   0    6   7    40    50    75    58                              
H   1.0   0    0   0    80    10     0     0                              
(prior                                                                    
art)                                                                      
__________________________________________________________________________
 0 = no damage                                                            
 100 = plants destroyed                                                   

                                  TABLE 8                                 
__________________________________________________________________________
Selective control of unwanted plants; postemergence treatment in the      
greenhouse                                                                
 ##STR288##                                                               
                 Test plants and % damage                                 
           Appln. rate                                                    
                 Zea                                                      
                    Chenop.                                               
                         Desmod.                                          
                              Euphorb.                                    
                                   Matric.                                
                                       Mercurial.                         
                                             Malva                        
                                                  Solanum                 
R.sup.1                                                                   
  R.sup.6  [kg/ha]                                                        
                  mays                                                    
                    album                                                 
                         tort.                                            
                              genic.                                      
                                   spp.                                   
                                       annua neglecta                     
                                                  nigrum                  
__________________________________________________________________________
H OCF.sub.2 CF.sub.3                                                      
           0.5   0  100  100  100  100 100   100  100                     
F OCF.sub.2 CF.sub.2 H                                                    
           0.5   3  100  100  100  100 100   100  100                     
Cl                                                                        
  OCF.sub.3                                                               
           1.0   9   67   92   84  85   45   100   88                     
H OCF.sub.2 CFHCL                                                         
           0.5   0   99  100   98  --   90   --    95                     
__________________________________________________________________________
  0 = no damage                                                           
 100 = plants destroyed                                                   

                                  TABLE 9                                 
__________________________________________________________________________
Control of unwanted plants in cotton; postemergence treatment in the      
greenhouse                                                                
 ##STR289##                                                               
           Test plants and % damage                                       
     Appln. rate                                                          
           Gossyp.                                                        
               Acanthosp.                                                 
                     Chenop.                                              
                          Datura                                          
                              Euphorb.                                    
                                   Solan.                                 
                                       Xanthium                           
                                            Sesbania                      
R.sup.6                                                                   
     [kg/ha]                                                              
            hirs.                                                         
               hisp. alb. stram.                                          
                              gen. nigr.                                  
                                       pens.                              
                                            exalt.                        
__________________________________________________________________________
SO.sub.2 CF.sub.3                                                         
     1.0    0  100   87   100 79   93  100  73                            
CF.sub.3                                                                  
     1.0   43  100   97    80 26   99   99  67                            
__________________________________________________________________________
 0 = no damage                                                            
 100 = plants destroyed                                                   

              TABLE 10                                                    
______________________________________                                    
Selective control of weeds in sugarbeets;                                 
postemergence treatment in the greenhouse                                 
 ##STR290##                                                               
                  Test plants and % damage                                
                                  Cheno-                                  
                  Appln. rate                                             
                            Beta  podium                                  
                                        Solanum                           
R.sup.1                                                                   
    R.sup.2       kg/ha     vulg. album nigrum                            
______________________________________                                    
     ##STR291##   2.0       10    85    100                               
H                                                                         
     ##STR292##   2.0       8     88    --                                
Cl                                                                        
     ##STR293##   1.0       3     67    100                               
F                                                                         
     ##STR294##   1.0       0     100   100                               
Cl                                                                        
     ##STR295##   1.0       0     85    100                               
______________________________________                                    
 0 =  no damage                                                           
 100 = plants destroyed
In view of the good tolerance by the crop plants and the many application methods possible, the agents according to the invention, or mixtures containing them, may be used not only on the crop plants listed in the tables, but also in a much larger range of crops for removing unwanted plants. The application rates vary from 0.1 to 15 kg/ha and more.
The following crop plants may be mentioned by way of example:
______________________________________                                    
Botanical name      Common name                                           
______________________________________                                    
Allium cepa         onions                                                
Ananas comosus      pineapples                                            
Arachis hypogaea    peanuts (groundnuts)                                  
Asparagus officinalis                                                     
                    asparagus                                             
Avena sativa        oats                                                  
Beta vulgaris spp. altissima                                              
                    sugarbeets                                            
Beta vulgaris spp. rapa                                                   
                    fodder beets                                          
Beta vulgaris spp. esculenta                                              
                    table beets, red beets                                
Brassica napus var. napus                                                 
                    rape                                                  
Brassica napus var. napobrassica                                          
Brassica napus var. rapa                                                  
                    turnips                                               
Brassica rapa var. silvestris                                             
Camellia sinensis   tea plants                                            
Carthamus tinctorius                                                      
                    safflower                                             
Carya illinoinensis pecan trees                                           
Citrus limon        lemons                                                
Citrus maxima       grapefruits                                           
Citrus reticulata                                                         
Citrus sinensis     orange trees                                          
Coffea arabica (Coffea                                                    
                    coffee plants                                         
canephora, Coffea liberica)                                               
Cucumis melo        melons                                                
Cucumis sativus     cucumbers                                             
Cynodon dactylon    Bermudagrass                                          
                    in turf and lawns                                     
Daucus carota       carrots                                               
Elais guineensis    oil palms                                             
Fragaria vesca      strawberries                                          
Glycine max         soybeans                                              
Gossypium hirsutum  cotton                                                
(Gossypium arboreum                                                       
Gossypium herbaceum                                                       
Gossypium vitifolium)                                                     
Helianthus annuus   sunflowers                                            
Helianthus tuberosus                                                      
Hevea brasiliensis  rubber plants                                         
Hordeum vulgare     barley                                                
Humulus lupulus     hops                                                  
Ipomoea bataras     sweet potatoes                                        
Juglans regia       walnut trees                                          
Lactuca sativa      lettuce                                               
Lens culinaris      lentils                                               
Linum usitatissimum flax                                                  
Lycopersicon lycopersicum                                                 
                    tomatoes                                              
Malus spp.          apple trees                                           
Manihot esculenta   cassava                                               
Medicago sativa     alfalfa (lucerne)                                     
Mentha piperita     peppermint                                            
Musa spp.           banana plants                                         
Nicothiana tabacum  tobacco                                               
(N. rustica)                                                              
Olea europaea       olive trees                                           
Oryza sativa        rice                                                  
Panicum millaceum                                                         
Phaseolus lunatus   limabeans                                             
Phaseolus mungo     mungbeans                                             
Phaseolus vulgaris  snapbeans, green beans,                               
                    dry beans                                             
Pennisetum glaucum                                                        
Petroselinum crispum                                                      
                    parsley                                               
ssp. tuberosum                                                            
Picea abies         Norway spruce                                         
Abies alba          fir trees                                             
Pinus spp.          pine trees                                            
Pisum sativum       English peas                                          
Prunus avium        cherry trees                                          
Prunus domestica    plum trees                                            
Prunus dulcis       almond trees                                          
Prunus persica      peach trees                                           
Pyrus communis      pear trees                                            
Ribes sylvestre     redcurrents                                           
Ribes uva-crispa                                                          
Ricinus communis                                                          
Saccharum officinarum                                                     
                    sugar cane                                            
Secale cereale      rye                                                   
Sesamum indicum     sesame                                                
Solanum tuberosum   Irish potatoes                                        
Sorghum bicolor (S. vulgare)                                              
                    grain sorghum                                         
Sorghum dochna                                                            
Spinacia oleracea   spinach                                               
Theobroma cacao     cacao plants                                          
Trifolium pratense  red clover                                            
Triticum aestivum   wheat                                                 
Vaccinium corymbosum                                                      
                    blueberries                                           
Vaccinium vitis -idaea                                                    
                    cranberries                                           
Vicia faba          tick beans                                            
Vigna sinensis (V. unguiculata)                                           
                    cow peas                                              
Vitis vinifera      grapes                                                
Zea mays            Indian corn, sweet corn,                              
                    maize                                                 
______________________________________
The 4H-3,1-benzoxazine derivatives of the formula I may be mixed with each other, or with numerous representatives of other herbicidal or growth-regulating active ingredient groups, and applied in such combinations. These combinations extend the spectrum of action, and synergistic effects are sometimes achieved. Examples of compounds which may be admixed are diazines, benzothiadiazinones, 2,6-dinitroanilines, N-phenylcarbamates, thiolcarbamates, halocarboxylic acids, triazines, amides, ureas, diphenyl ethers, triazinones, uracils, benzofuran derivatives, etc. A number of active ingredients which, together with the new compounds, give mixtures useful for widely varying applications are listed below by way of example.
______________________________________                                    
 ##STR296##                                                               
R                 R.sup.1     R.sup.2                                     
______________________________________                                    
 ##STR297##       NH.sub.2    Cl                                          
 ##STR298##       NH.sub.2    Br                                          
 ##STR299##       OCH.sub.3   OCH.sub.3                                   
 ##STR300##       N(CH.sub.3).sub.2                                       
                              Cl                                          
 ##STR301##       OCH.sub.3   OCH.sub.3                                   
 ##STR302##       NH.sub.2    Cl                                          
 ##STR303##       N(CH.sub.3).sub.2                                       
                              Cl                                          
 ##STR304##       NHCH.sub.3  Cl                                          
 ##STR305##       OCH.sub.3   Cl                                          
 ##STR306##       NH.sub.2    Br                                          
 ##STR307##       OCH.sub.3   OCH.sub.3                                   
 ##STR308##       NHCH.sub.3  Cl                                          
______________________________________                                    

______________________________________                                    
 ##STR309##                                                               
R             R.sup.1 R.sup.2   R.sup.3                                   
______________________________________                                    
H             i-C.sub.3 H.sub.7                                           
                      H         H (salts)                                 
H             i-C.sub.3 H.sub.7                                           
                      H         CH.sub.3 (salts)                          
H             i-C.sub.3 H.sub.7                                           
                      H         Cl (salts)                                
CH.sub.2OCH.sub.3                                                         
              i-C.sub.3 H.sub.7                                           
                      H         H                                         
H             i-C.sub.3 H.sub.7                                           
                      H         F (salts)                                 
CH.sub.2OCH.sub.3                                                         
              i-C.sub.3 H.sub.7                                           
                      H         Cl                                        
CH.sub.2OCH.sub.3                                                         
              i-C.sub.3 H.sub.7                                           
                      H         F                                         
CN            i-C.sub.3 H.sub.7                                           
                      H         Cl                                        
______________________________________                                    

______________________________________                                    
 ##STR310##                                                               
R     R.sup.1   R.sup.2 R.sup.3     R.sup.4                               
______________________________________                                    
H     H.sub.3 CSO.sub.2                                                   
                H       n-C.sub.3 H.sub.7                                 
                                    n-C.sub.3 H.sub.7                     
H     F.sub.3 C H       C.sub.2 H.sub.5                                   
                                    C.sub.4 H.sub.9                       
H     F.sub.3 C H       n-C.sub.3 H.sub.7                                 
                                    n-C.sub.3 H.sub.7                     
H     F.sub.3 C H       CH.sub.2CH.sub.2 Cl                               
                                    n-C.sub.3 H.sub.7                     
H     tert-C.sub.4 H.sub.9                                                
                H       sec-C.sub.4 H.sub.9                               
                                    sec-C.sub.4 H.sub.9                   
H     SO.sub.2 NH.sub.2                                                   
                H       n-C.sub.3 H.sub.7                                 
                                    n-C.sub.3 H.sub.7                     
H     F.sub.3 C H       n-C.sub.3 H.sub.7                                 
                                     ##STR311##                           
H.sub.3 C                                                                 
      H.sub.3 C H       H           sec-C.sub.4 H.sub.9                   
H.sub.3 C                                                                 
      H.sub.3 C H       H           CH(C.sub.2 H.sub.5).sub.2             
H     F.sub.3 C NH.sub.2                                                  
                        n-C.sub.3 H.sub.7                                 
                                    n-C.sub. 3 H.sub.7                    
H     H.sub.3 C H       n-C.sub.3 H.sub.7                                 
                                    n-C.sub.3 H.sub.7                     
H     i-C.sub.3 H.sub.7                                                   
                H       n-C.sub.3 H.sub.7                                 
                                    n-C.sub.3 H.sub.7                     
______________________________________                                    

______________________________________                                    
 ##STR312##                                                               
R              R.sup.1 R.sup.2                                            
______________________________________                                    
 ##STR313##    H       i-C.sub.3 H.sub.7                                  
CH.sub.3       H                                                          
                        ##STR314##                                        
 ##STR315##    H                                                          
                        ##STR316##                                        
 ##STR317##    H       CH.sub.2CCH.sub.2 Cl                               
 ##STR318##    H       i-C.sub.3 H.sub.7                                  
 ##STR319##    H                                                          
                        ##STR320##                                        
 ##STR321##    H       CH.sub.3                                           
 ##STR322##    H       CH.sub. 3                                          
CH.sub.3       H                                                          
                        ##STR323##                                        
 ##STR324##    H                                                          
                        ##STR325##                                        
______________________________________                                    

______________________________________                                    
 ##STR326##                                                               
R                 R.sup.1                                                 
                         R.sup.2                                          
______________________________________                                    
 ##STR327##       H      CH.sub.3                                         
 ##STR328##       H      C.sub.2 H.sub.5                                  
 ##STR329##       H      C.sub.2 H.sub.5                                  
 ##STR330##       CH.sub.3                                                
                         CH.sub.3                                         
 ##STR331##       H      CH.sub.3                                         
 ##STR332##       H      C.sub.2 H.sub.5                                  
 ##STR333##       H      C.sub.2 H.sub.5                                  
 ##STR334##       H      CH.sub.3                                         
 ##STR335##       H      CH.sub.3                                         
 ##STR336##                                                               
______________________________________                                    

______________________________________                                    
 ##STR337##                                                               
R            R.sup.1   R.sup.2                                            
______________________________________                                    
i-C.sub.3 H.sub.7                                                         
             i-C.sub.3 H.sub.7                                            
                       CH.sub.2CClCCl.sub.2                               
i-C.sub.3 H.sub.7                                                         
             i-C.sub.3 H.sub.7                                            
                       CH.sub.2CClCHCl                                    
n-C.sub.3 H.sub.7                                                         
             n-C.sub.3 H.sub.7                                            
                       C.sub.2 H.sub.5                                    
 ##STR338##  C.sub.2 H.sub.5                                              
                       C.sub.2 H.sub.5                                    
sec-C.sub.4 H.sub.9                                                       
             sec-C.sub.4 H.sub.9                                          
                       C.sub.2 H.sub.5                                    
n-C.sub.3 H.sub.7                                                         
             n-C.sub.3 H.sub.7                                            
                       n-C.sub.3 H.sub.7                                  
C.sub.2 H.sub.5                                                           
             C.sub.2 H.sub.5                                              
                        ##STR339##                                        
sec-C.sub.4 H.sub.9                                                       
             sec-C.sub.4 H.sub.9                                          
                        ##STR340##                                        
 ##STR341##  C.sub.2 H.sub.5                                              
                       C.sub.2 H.sub.5                                    
i-C.sub.3 H.sub.7                                                         
             i-C.sub.3 H.sub.7                                            
                        ##STR342##                                        
i-C.sub.3 H.sub.7                                                         
             i-C.sub.3 H.sub.7                                            
                        ##STR343##                                        
______________________________________                                    
 ##STR344##                                                               
______________________________________                                    
CH.sub.2CClCHCl                                                           
CH.sub.2CClCCl.sub.2                                                      
 ##STR345##                                                               
______________________________________                                    

______________________________________                                    
 ##STR346##                                                               
R                 X     Y      R.sup.1                                    
______________________________________                                    
CH.sub.3          Cl    Cl     Na                                         
 ##STR347##       Cl    H      CH.sub.3                                   
 ##STR348##       H     H      H (salts)                                  
Cl                Cl    Cl     Na                                         
 ##STR349##       H     CH.sub.3                                          
                               CH.sub.3                                   
 ##STR350##       H     CH.sub.3                                          
                               C.sub.2 H.sub.5                            
C.sub.2 H.sub.5   Cl    Cl     Na                                         
 ##STR351##       H     CH.sub.3                                          
                               i-C.sub.3 H.sub.7                          
 ##STR352##       H     CH.sub.3                                          
                               CH.sub.3                                   
 ##STR353##       H     CH.sub.3                                          
                               CH.sub.2CH(CH.sub.3).sub.2                 
 ##STR354##       H     CH.sub.3                                          
                               Na                                         
 ##STR355##       H     CH.sub.3                                          
                               Na                                         
 ##STR356##       H     CH.sub.3                                          
                               CH.sub.3                                   
______________________________________                                    

______________________________________                                    
 ##STR357##                                                               
R     R.sup.1    X       R.sup.2                                          
                               R.sup.3                                    
______________________________________                                    
H     tert-C.sub.4 H.sub.9                                                
                 SCH.sub.3                                                
                         H     C.sub.2 H.sub.5                            
H     C.sub.2 H.sub.5                                                     
                 SCH.sub.3                                                
                         H     C.sub.2 H.sub.5                            
H     i-C.sub.3 H.sub.7                                                   
                 SCH.sub.3                                                
                         H     C.sub.2 H.sub.5                            
H     CH.sub.3   SCH.sub.3                                                
                         H     i-C.sub.3 H.sub.7                          
H     i-C.sub.3 H.sub.7                                                   
                 Cl      H     C.sub.2 H.sub.5                            
H     i-C.sub.3 H.sub.7                                                   
                 Cl      H                                                
                                ##STR358##                                
H     C.sub.2 H.sub.5                                                     
                 Cl      H     C.sub.2 H.sub.5                            
H     C.sub.2 H.sub.5                                                     
                 Cl      H                                                
                                ##STR359##                                
H     i-C.sub.3 H.sub.7                                                   
                 Cl      H     i-C.sub.3 H.sub.7                          
H     i-C.sub.3 H.sub.7                                                   
                 OCH.sub.3                                                
                         H     i-C.sub.3 H.sub.7                          
       ##STR360##                                                         
                 Cl      H                                                
                                ##STR361##                                
H     C.sub.2 H.sub.5                                                     
                 Cl      H                                                
                                ##STR362##                                
H     C.sub.2 H.sub.5                                                     
                 Cl      H                                                
                                ##STR363##                                
______________________________________                                    

__________________________________________________________________________
 ##STR364##                                                               
R           R.sup.1        R.sup.2                                        
__________________________________________________________________________
CH.sub.3    CH.sub.3       CH(C.sub.6 H.sub.5).sub.2                      
 ##STR365## H                                                             
                            ##STR366##                                    
 ##STR367## H                                                             
                            ##STR368##                                    
 ##STR369## H              C.sub.2 H.sub.5                                
 ##STR370## H              C.sub.2 H.sub.5                                
 ##STR371## H                                                             
                            ##STR372##                                    
 ##STR373##                                                               
             ##STR374##    CH.sub.2 Cl                                    
 ##STR375##                                                               
             ##STR376##    CH.sub.2 Cl                                    
 ##STR377## CH.sub.2OCH.sub.3                                             
                           CH.sub.2 Cl                                    
 ##STR378##                                                               
             ##STR379##    CH.sub.2 Cl                                    
 ##STR380## i-C.sub.3 H.sub.7                                             
                           CH.sub.2 Cl                                    
 ##STR381## CH.sub.2OCH.sub.2CH(CH.sub.3).sub.2                           
                           CH.sub.2 Cl                                    
 ##STR382## CH.sub.2On-C.sub.4 H.sub.9                                    
                           CH.sub.2 Cl                                    
 ##STR383## CH.sub.2OC.sub.2 H.sub.5                                      
                           CH.sub.2 Cl                                    
 ##STR384##                                                               
             ##STR385##    CH.sub.2 Cl                                    
 ##STR386## CH.sub.2CH.sub.2OCH.sub.3                                     
                           CH.sub.2 Cl                                    
 ##STR387##                                                               
             ##STR388##    CH.sub.2 Cl                                    
 ##STR389##                                                               
             ##STR390##    CH.sub.2 Cl                                    
 ##STR391##                                                               
             ##STR392##    CH.sub.2 Cl                                    
 ##STR393##                                                               
             ##STR394##    CH.sub.2 Cl                                    
CH.sub.3    CH.sub.3                                                      
                            ##STR395##                                    
C.sub.2 H.sub.5                                                           
            C.sub.2 H.sub.5                                               
                            ##STR396##                                    
CH.sub.2CHCH.sub.2                                                        
            CH.sub.2CHCH.sub.2                                            
                           CH.sub.2 Cl                                    
 ##STR397##                                                               
             ##STR398##    CH.sub.2 Cl                                    
 ##STR399##                                                               
             ##STR400##    CH.sub.2 Cl                                    
 ##STR401## H                                                             
                            ##STR402##                                    
 ##STR403## H              CH.sub.3                                       
 ##STR404## H              CH.sub.3                                       
__________________________________________________________________________

______________________________________                                    
 ##STR405##                                                               
X              Y           R                                              
______________________________________                                    
Br             Br          H (salts)                                      
I              I           H (salts)                                      
Br             Br                                                         
                            ##STR406##                                    
 ##STR407##            salts, esters                                      
 ##STR408##            salts, esters                                      
______________________________________                                    

______________________________________                                    
 ##STR409##                                                               
R              R.sup.1                                                    
                      R.sup.2   R.sup.3                                   
______________________________________                                    
 ##STR410##    H      CH.sub.3  CH.sub.3                                  
 ##STR411##    H      CH.sub.3  CH.sub.3                                  
 ##STR412##    H      CH.sub.3  CH.sub.3                                  
 ##STR413##    H      CH.sub.3  H                                         
 ##STR414##    CH.sub.3                                                   
                      CH.sub.3  H                                         
 ##STR415##    H      CH.sub.3  CH.sub.3                                  
 ##STR416##    H      CH.sub.3  CH.sub.3                                  
 ##STR417##    H                                                          
                       ##STR418##                                         
                                H                                         
 ##STR419##    H      CH.sub.3  CH.sub.3                                  
 ##STR420##    H      CH.sub.3                                            
                                 ##STR421##                               
 ##STR422##    H      CH.sub.3  OCH.sub.3                                 
 ##STR423##    H      CH.sub.3  CH.sub.3                                  
 ##STR424##    H                                                          
                       ##STR425##                                         
                                H                                         
 ##STR426##    H      CH.sub.3  OCH.sub.3                                 
 ##STR427##    H      CH.sub.3  CH.sub.3                                  
 ##STR428##    H      CH.sub.3  CH.sub.3                                  
 ##STR429##    H      CH.sub.3  CH.sub.3                                  
 ##STR430##    H      CH.sub.3  CH.sub.3                                  
 ##STR431##    H      CH.sub.3  OCH.sub.3                                 
 ##STR432##    H      CH.sub.3  OCH.sub.3                                 
 ##STR433##    H      CH.sub.3  H                                         
 ##STR434##    CH.sub.3                                                   
                      CH.sub.3  H                                         
 ##STR435##    CH.sub.3                                                   
                      CH.sub.3  H                                         
 ##STR436##    H      C.sub.2 H.sub.5                                     
                                C.sub.2 H.sub.5                           
 ##STR437##    H      CH.sub.3  CH.sub.3                                  
 ##STR438##    H      CH.sub.3  OCH.sub.3                                 
 ##STR439##    H      CH.sub.3  CH.sub.3                                  
 ##STR440##                                                               
______________________________________                                    

______________________________________                                    
 ##STR441##                                                               
R          R.sup.1   R.sup.2  R.sup.3                                     
______________________________________                                    
Cl         Cl        Cl       H                                           
F          Cl        Cl       H                                           
NO.sub.2   CF.sub.3  H        H                                           
Cl         CF.sub.3  H        COOH (salts)                                
Cl         Cl        H        H                                           
Cl         Cl        H        OCH.sub.3                                   
Cl         Cl        H                                                    
                               ##STR442##                                 
H          CF.sub.3  Cl       H                                           
H          CF.sub.3  Cl       OC.sub.2 H.sub.5                            
______________________________________                                    

______________________________________                                    
 ##STR443##                                                               
R            R.sup.1           R.sup.2                                    
______________________________________                                    
tert-C.sub.4 H.sub.9                                                      
             NH.sub.2          SCH.sub.3                                  
tert-C.sub.4 H.sub.9                                                      
             NCHCH(CH.sub.3).sub.2                                        
                               SCH.sub.3                                  
 ##STR444##  NH.sub.2          CH.sub.3                                   
______________________________________                                    

______________________________________                                    
 ##STR445##                                                               
R          R.sup.1   R.sup.2  R.sup.3                                     
______________________________________                                    
H          CH.sub.3  Br                                                   
                               ##STR446##                                 
H          CH.sub.3  Br       i-C.sub.3 H.sub.7                           
H          CH.sub.3  Cl       tert-C.sub.4 H.sub.9                        
H          CH.sub.3  Cl                                                   
                               ##STR447##                                 
 ##STR448##                                                               
______________________________________                                    

______________________________________                                    
 ##STR449##                                                               
R           R.sup.1    R.sup.2  R.sup.3                                   
______________________________________                                    
 ##STR450## sec-C.sub.4 H.sub.9                                           
                       H        H                                         
H           CH.sub.3   H        H (salts, esters)                         
H           sec-C.sub.4 H.sub.9                                           
                       H        H (salts, esters)                         
 ##STR451## tert-C.sub.4 H.sub.9                                          
                       H        H                                         
 ##STR452## tert-C.sub.4 H.sub.9                                          
                       H        CH.sub.3                                  
H           i-C.sub.3 H.sub.7                                             
                       CH.sub.3 H (salts, esters)                         
H           tert-C.sub.4 H.sub.9                                          
                       H        H (salts)                                 
______________________________________                                    

______________________________________                                    
 ##STR453##                                                               
X               Y           R                                             
______________________________________                                    
CF.sub.3        H           CH.sub.3                                      
H               F           CH.sub.3                                      
 ##STR454##                                                               
______________________________________                                    

______________________________________                                    
 ##STR455##                                                               
R                      R.sup.1                                            
______________________________________                                    
CH.sub.3               C.sub.2 H.sub.5                                    
 ##STR456##            C.sub.2 H.sub.5                                    
 ##STR457##            C.sub.2 H.sub.5                                    
______________________________________                                    

______________________________________                                    
 ##STR458##                                                               
R                         R.sup.1                                         
______________________________________                                    
 ##STR459##               CH.sub.3                                        
 ##STR460##               CH.sub.3                                        
 ##STR461##               CH.sub.3                                        
______________________________________                                    

______________________________________                                    
 ##STR462##                                                               
R        R.sup.1  R.sup.2  X                                              
______________________________________                                    
CH.sub.3 CH.sub.3 H                                                       
                            ##STR463##                                    
CH.sub.3 CH.sub.3 Br       CH.sub.3 OSO.sub.2 O                           
CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 OSO.sub.2O                            
CH.sub.3 CH.sub.3 CH.sub.3 CF.sub.3SO.sub.2                               
 ##STR464##                                                               
 ##STR465##                                                               
 ##STR466##                                                               
 ##STR467##                                                               
 ##STR468##                                                               
 ##STR469##                                                               
 ##STR470##                                                               
 ##STR471##                                                               
 ##STR472##                                                               
 ##STR473##                                                               
 ##STR474##                                                               
 ##STR475##                                                               
 ##STR476##                                                               
______________________________________                                    

______________________________________                                    
 ##STR477##                                                               
             R                                                            
______________________________________                                    
             CN                                                           
             CSNH.sub.2                                                   
______________________________________                                    

______________________________________                                    
 ##STR478##                                                               
R       R.sup.1 R.sup.2  R.sup.3 R.sup.4                                  
______________________________________                                    
H       Cl      NH.sub.2 Cl      (salts, esters,                          
                                 amides)                                  
Cl      Cl      H        Cl      Na                                       
H       I       I        I       H                                        
Cl      H       Cl       OCH.sub.3                                        
                                 H                                        
Cl      Cl      H        Cl      (CH.sub.3).sub.2 NH.sub.2                
______________________________________                                    

______________________________________                                    
 ##STR479##                                                               
R              R.sup.1  R.sup.2                                           
______________________________________                                    
 ##STR480##    CH.sub.3 H (salts, esters, amides)                         
 ##STR481##    H        H (salts, esters, amides)                         
 ##STR482##    H        H (salts, esters, amides)                         
 ##STR483##    H        H (salts, esters, amides)                         
 ##STR484##    CH.sub.3 H (salts, esters, amides)                         
 ##STR485##    CH.sub.3 H (salts, esters, amides)                         
 ##STR486##                                                               
 ##STR487##          (salts, esters, amides)                              
 ##STR488##          (salts, esters, amides)                              
 ##STR489##          (salts, esters, amides)                              
______________________________________                                    

______________________________________                                    
 ##STR490##                                                               
R               R.sup.1     R.sup.2                                       
______________________________________                                    
OH              CH.sub.3    Na                                            
CH.sub.3        CH.sub.3    Na                                            
CH.sub.3        CH.sub.3    OH                                            
ONa             CH.sub.3    Na                                            
______________________________________                                    

______________________________________                                    
 ##STR491##                                                               
R             R.sup.1         R.sup.2                                     
______________________________________                                    
 ##STR492##   CH.sub.2OC.sub.2 H.sub.5                                    
                              CH.sub.3                                    
 ##STR493##   i-C.sub.3 H.sub.7OCH.sub.2                                  
                              CH.sub.3                                    
 ##STR494##   CH.sub.2OC.sub.2 H.sub.5                                    
                              CH.sub.3                                    
 ##STR495##   i-C.sub.3 H.sub.7                                           
                              NHCH.sub.3                                  
 ##STR496##                                                               
 ##STR497##                                                               
 ##STR498##                                                               
 ##STR499##                                                               
 ##STR500##                                                               
 ##STR501##                                                               
 ##STR502##                                                               
 ##STR503##                                                               
 ##STR504##                                                               
 ##STR505##                                                               
 ##STR506##                                                               
 ##STR507##                                                               
 ##STR508##                                                               
 ##STR509##                                                               
 ##STR510##                                                               
 ##STR511##                                                               
 ##STR512##                                                               
NH.sub.4 SCN                                                              
 ##STR513##                                                               
 ##STR514##                                                               
 ##STR515##                                                               
 ##STR516##                                                               
 ##STR517##                                                               
 ##STR518##                                                               
 ##STR519##                                                               
 ##STR520##                                                               
 ##STR521##                                                               
 ##STR522##                                                               
 ##STR523##                                                               
 ##STR524##                                                               
 ##STR525##                                                               
______________________________________
It may also be useful to apply the new compounds, either alone or in combination with other herbicides, in admixture with other crop protection agents, e.g., agents for combating pests or phytopathogenic fungi or bacteria. The compounds may also be mixed with solutions of mineral matters used to remedy nutritional or trace element deficiencies. It may also be advantaeous to apply the compounds according to the invention (either on their own or in possible combinations) in admixture with solid or liquid mineral fertilizers.

Claims (12)

We claim:
1. 4H-3,1-Benzoxazine derivatives of the formula ##STR526## where Y is oxygen or sulfur, .Iadd.R2 is .Iaddend.Ar(R6)n, Ar denoting phenyl, R6 denoting haloalkoxy or haloalkylmercapto, each of 1 to 4 carbon atoms, and n being 1 or 2.
2. 2-(p-Trifluoromethoxy-phenyl)-3,1-benzoxazin-4-one.
3. 2-(m-Trifluoromethoxy-phenyl)-3,1-benzoxazin-4-one.
4. 2-(m-1',1',2',2'-Tetrafluoroethoxy-phenyl)-3,1-benzoxazin-4-one.
5. A herbicide comprising a solid and/or liquid inert carrier and a 4H-3,1-benzoxazine derivative of the formula I as claimed in claim 1.
6. A process for combating unwanted plant growth, wherein the plants or the soil are treated with a herbicidally effective amount of a 4H-3,1-benzoxazine derivative of the formula I as claimed in claim 1.
7. A compound as set forth in claim 1 wherein n is 1.
8. 2-(m-chlorodifluoromethoxy-phenyl)-3,1-benzoxazin-4-one.
9. 2-(m-trifluoromethylmercapto-phenyl)-3,1-benzoxazin-4-one.
10. 2-(m-chlorodifluoromethylmercapto-phenyl)-3,1-benzoxazin-4-one. .Iadd.
11. 4H-3,1-Benzoxazine derivatives of the formula ##STR527## where R1 is fluorine or chlorine, Y is oxygen or sulfur and R2 is phenyl. .Iaddend. .Iadd.
12. A 4H-3,1-Benzoxazine derivative as in claim 1, wherein R1 is fluorine and Y is oxygen. .Iaddend. .Iadd.13. A 4H-3,1-Benzoxazine derivative as in claim 1, wherein R1 is chlorine and Y is oxygen. .Iaddend.
US06/506,316 1979-04-12 1983-06-21 4H-3,1-Benzoxazine derivatives Expired - Fee Related USRE32087E (en)

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US4657893A (en) 1984-05-09 1987-04-14 Syntex (U.S.A.) Inc. 4H-3,1-benzoxazin-4-ones and related compounds and use as enzyme inhibitors
US4673740A (en) 1985-04-19 1987-06-16 Basf Aktiengesellschaft Preparation of substituted 2-phenyl-4H-3,1-benzoxazin-4-ones
US5093364A (en) * 1988-08-24 1992-03-03 Schering Agrochemicals Limited 5-fluoroanthranilic fungicides
USRE35573E (en) 1986-09-11 1997-07-29 Thermalloy, Inc. Heat sink clip assembly
US6187952B1 (en) 1997-12-12 2001-02-13 Clariant Gmbh Two-step production of 3-chloro-4-fluoro-benzoyl chloride by chlorination

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DE3037970A1 (en) * 1980-10-08 1982-05-13 Basf Ag, 6700 Ludwigshafen 4H-3,1-BENZOXAZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE FOR CONTROLLING UNWANTED PLANT GROWTH
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Publication number Priority date Publication date Assignee Title
US4657893A (en) 1984-05-09 1987-04-14 Syntex (U.S.A.) Inc. 4H-3,1-benzoxazin-4-ones and related compounds and use as enzyme inhibitors
US4673740A (en) 1985-04-19 1987-06-16 Basf Aktiengesellschaft Preparation of substituted 2-phenyl-4H-3,1-benzoxazin-4-ones
USRE35573E (en) 1986-09-11 1997-07-29 Thermalloy, Inc. Heat sink clip assembly
US5093364A (en) * 1988-08-24 1992-03-03 Schering Agrochemicals Limited 5-fluoroanthranilic fungicides
US6187952B1 (en) 1997-12-12 2001-02-13 Clariant Gmbh Two-step production of 3-chloro-4-fluoro-benzoyl chloride by chlorination

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EP0084893A3 (en) 1983-08-24
HU185882B (en) 1985-04-28
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US4315766A (en) 1982-02-16
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GR66801B (en) 1981-04-29
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ES8200354A1 (en) 1981-11-01
EP0084893A2 (en) 1983-08-03
IL59775A0 (en) 1980-06-30
EP0084893B1 (en) 1987-01-14
IL59775A (en) 1984-03-30
AR226176A1 (en) 1982-06-15
DE2914915A1 (en) 1980-10-30
NZ193416A (en) 1982-09-07
DD149995A5 (en) 1981-08-12
CS212229B2 (en) 1982-03-26
TR21512A (en) 1984-07-01
RO81078A (en) 1983-02-01
BR8002142A (en) 1980-11-25
JPH0224825B2 (en) 1990-05-30
EP0017931A2 (en) 1980-10-29
AU5737580A (en) 1980-10-16
PT71080A (en) 1980-05-01
RO81078B (en) 1983-01-30
ZA802173B (en) 1981-06-24
SU980601A3 (en) 1982-12-07
CA1145748A (en) 1983-05-03

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