USRE19608E - Process for the production of - Google Patents
Process for the production of Download PDFInfo
- Publication number
- USRE19608E USRE19608E US19608DE USRE19608E US RE19608 E USRE19608 E US RE19608E US 19608D E US19608D E US 19608DE US RE19608 E USRE19608 E US RE19608E
- Authority
- US
- United States
- Prior art keywords
- solution
- anesthetic
- injection
- solutions
- disodium phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title description 4
- 238000000034 method Methods 0.000 title description 4
- 239000000243 solution Substances 0.000 description 27
- 230000003444 anaesthetic Effects 0.000 description 14
- 238000002347 injection Methods 0.000 description 9
- 239000007924 injection Substances 0.000 description 9
- UCTWMZQNUQWSLP-VIFPVBQESA-N Epinephrine Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 8
- 229960005139 epinephrine Drugs 0.000 description 8
- UIIMBOGNXHQVGW-UHFFFAOYSA-M NaHCO3 Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 7
- 239000002253 acid Substances 0.000 description 7
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 7
- 229910000397 disodium phosphate Inorganic materials 0.000 description 7
- 235000019800 disodium phosphate Nutrition 0.000 description 7
- 239000001488 sodium phosphate Substances 0.000 description 7
- 230000001264 neutralization Effects 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 4
- WXYMJKAAOYJOBV-UHFFFAOYSA-N Cl.NC1=CC=C(C(=O)C(C(O)(N)CC)CC)C=C1 Chemical compound Cl.NC1=CC=C(C(=O)C(C(O)(N)CC)CC)C=C1 WXYMJKAAOYJOBV-UHFFFAOYSA-N 0.000 description 3
- 210000004907 Glands Anatomy 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 231100000344 non-irritating Toxicity 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- HCBIBCJNVBAKAB-UHFFFAOYSA-N Procaine hydrochloride Chemical compound Cl.CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 HCBIBCJNVBAKAB-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-M 3-carboxy-2,3-dihydroxypropanoate Chemical compound OC(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-M 0.000 description 1
- WGJLVUAKMPESRR-UHFFFAOYSA-N Cl.C(C1=CC=CC=C1)(=O)OC(C(N)(C)C)(C(C)(C)CC)N Chemical compound Cl.C(C1=CC=CC=C1)(=O)OC(C(N)(C)C)(C(C)(C)CC)N WGJLVUAKMPESRR-UHFFFAOYSA-N 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N Procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000002690 local anesthesia Methods 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- XXWBHIRIHFZSNM-UHFFFAOYSA-M sodium;(2-methoxyphenyl) hydrogen phosphate Chemical compound [Na+].COC1=CC=CC=C1OP(O)([O-])=O XXWBHIRIHFZSNM-UHFFFAOYSA-M 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000001519 tissues Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
Definitions
- the anesthetic solution may be prepared by mixing a suprarenal gland preparation (for instance suprarenin) with anesthetic preparations, such as for instance p-aminobenzoyldiethyl-amino-ethanol hydrochloride (known as novocain), a-dimethyl amino-b-methyl butanol hydrochloride, benzoyl-ethyl-tetramethyl diamino-isopropanol hydrochloride. Solutions thus treated by adding sodium bicarbonate are unsatisfactory because they are unstable and become decomposed or cloudy in a very short time, so as to be unserviceable for injection.
- a suprarenal gland preparation for instance suprarenin
- anesthetic preparations such as for instance p-aminobenzoyldiethyl-amino-ethanol hydrochloride (known as novocain)
- novocain p-aminobenzoyldiethyl-amino-ethanol hydrochloride
- aqueous solvent and the other ingredients are kept separate in the respective compartments of such a receptacle, yet handy for immediate use in preparing a solution for injection.
- composition is given, the quantities being understood as applying to 1 cubic centimeter 0! solution: .02 grams of p-aminobenzoyl diethyl amino ethanol hydrochloride (known as novocain, an anesthetic), .000036 grams of o-dioxyphenylethanolmethylamin bitartrate (known as epinephrine, adrenaline, or suprarenin), .003 grams of disodium phosphate (siirensen).
- novocain an anesthetic
- o-dioxyphenylethanolmethylamin bitartrate known as epinephrine, adrenaline, or suprarenin
- disodium phosphate disodium phosphate
- the step which consists in adding to an anesthetic solution containing epinephrine, an amount oi disodium phosphate suflicient to impart a slightly alkaline character to the solution.
- the step which consists in adding to a solution of p-aminobenzoyl-diethyl-amino-ethanol hydrochloride containing epinephrine, an amount of disodium phosphate suflicient to impart a slightly alkaline character to the solution.
- An anesthetic solution for hypodermic injection containing a solvent, an acid-containing anesthetic material for local anesthesia, epinephrine, and an alkaline bufier salt of a stable acid in sumcient quantity to impart a nearly neutral character to the solution.
- An anesthetic composition to be mixed with water to produce an anesthetic solution comprising an acid-containing local anesthetic material, epinephrine, and an alkaline butter salt of a stable acid in suiiicient quantity to produce a nearly neutral condition in the resulting solution.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
Reissued June 11, 1935 UNITED STATES PATENT OFFICE PROCESS FOR THE PRODUCTION OF ANESTHETIC SOLUTIONS Max Woelm, Spangenberg,
assignor, by mesne assignments, to
near Kassel, Germany, Novocol Chemical Mfg. Co. Inc., Brooklyn, N. Y., a corporation of New York No Drawing. Original No. 1,916,089, dated June 1933, Serial No. 294,931, July 23, 1928. Ap-
plication for reissue flied April 8, 1935, Serial No. 14,445. In Germany May 2, 1927 Claims.
It is known (see for instance an article by Lawen and Gross in Miinchener Medizinische Wochenschriit 1910, No. 39) that the addition of sodium bicarbonate to such solutions of either 5 organic or synthetic suprarenal gland preparations as have an anesthetic effect and simultaneously render tissues bloodless, will reduce the acidity of the solution and render it more suitable for injection. The anesthetic solution may be prepared by mixing a suprarenal gland preparation (for instance suprarenin) with anesthetic preparations, such as for instance p-aminobenzoyldiethyl-amino-ethanol hydrochloride (known as novocain), a-dimethyl amino-b-methyl butanol hydrochloride, benzoyl-ethyl-tetramethyl diamino-isopropanol hydrochloride. Solutions thus treated by adding sodium bicarbonate are unsatisfactory because they are unstable and become decomposed or cloudy in a very short time, so as to be unserviceable for injection.
I have found that I can obtain non-irritating, stable, comparatively alkaline solutions 0! suprarenal gland preparations by adding disodium phosphate instead of the sodium bicarbonate above referred to. The disodium phosphate imparts a slightly alkaline character to the solutions and renders them stable for a sufficient length of time to permit their use for injection. The addition of a predetermined amount of the buffer disodium phosphate makes the acid anesthetic solution less acid so that it becomes nearly neutral and, with further additions, the solution passes to neutral and then, in the preferred form of the invention, becomes slightly alkaline (nearly neutral). When the solutions are rendered slightly alkaline they remain clear for at least ten minutes, which is a sufiicient length of time to permit the injection to be successfully accomplished.
In order to avoid with absolute certainty the decomposition of the alkali-sensitive bases, the individual ingredients intended for preparing the solution are kept separate until shortly before such solution is to be used. For storing these ingredients separately, in the proper proportions for producing the desired solution, I prefer to employ two-compartment flasks or receptacles of any suitable well-known or approved construction, such as for instance those disclosed in U. 5. Patents 1,570,346 and 1,592,632.
The aqueous solvent and the other ingredients (the latter in a dry condition) are kept separate in the respective compartments of such a receptacle, yet handy for immediate use in preparing a solution for injection.
As an example, the following composition is given, the quantities being understood as applying to 1 cubic centimeter 0! solution: .02 grams of p-aminobenzoyl diethyl amino ethanol hydrochloride (known as novocain, an anesthetic), .000036 grams of o-dioxyphenylethanolmethylamin bitartrate (known as epinephrine, adrenaline, or suprarenin), .003 grams of disodium phosphate (siirensen).
I claim:
1. In the process for the production of nonirritating anesthetic solutions stable for a sufficient length 01. time to permit of their use for injection, the step which consists in adding to an anesthetic solution containing epinephrine, an amount oi disodium phosphate suflicient to impart a slightly alkaline character to the solution.
2. In the process for the production of non irritating anesthetic solutions stable for a sumcient length of time to permit of their use for injection, the step which consists in adding to a solution of p-aminobenzoyl-diethyl-amino-ethanol hydrochloride containing epinephrine, an amount of disodium phosphate suflicient to impart a slightly alkaline character to the solution.
3. An anesthetic solution for hypodermic injection containing a solvent, an acid-containing anesthetic material for local anesthesia, epinephrine, and an alkaline bufier salt of a stable acid in sumcient quantity to impart a nearly neutral character to the solution.
4. An anesthetic solution 101' hypodermic injection containing water as a solvent, an acid salt oi procaine, epinephrine, and a suflicient quantity 40 of disodium phosphate to produce a nearly neutral solution.
5. An anesthetic composition to be mixed with water to produce an anesthetic solution comprising an acid-containing local anesthetic material, epinephrine, and an alkaline butter salt of a stable acid in suiiicient quantity to produce a nearly neutral condition in the resulting solution.
MAX WOELM.
Publications (1)
Publication Number | Publication Date |
---|---|
USRE19608E true USRE19608E (en) | 1935-06-11 |
Family
ID=2083866
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US19608D Expired USRE19608E (en) | Process for the production of |
Country Status (1)
Country | Link |
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US (1) | USRE19608E (en) |
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0
- US US19608D patent/USRE19608E/en not_active Expired
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