US9428589B2 - Tethering cysteine residues using cyclic disulfides - Google Patents

Tethering cysteine residues using cyclic disulfides Download PDF

Info

Publication number
US9428589B2
US9428589B2 US14/440,978 US201314440978A US9428589B2 US 9428589 B2 US9428589 B2 US 9428589B2 US 201314440978 A US201314440978 A US 201314440978A US 9428589 B2 US9428589 B2 US 9428589B2
Authority
US
United States
Prior art keywords
protein
compound
alkyl
formula
certain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
US14/440,978
Other versions
US20150284478A1 (en
Inventor
Jeffrey N. Agar
Joseph Salisbury
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brandeis University
Original Assignee
Brandeis University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201261726776P priority Critical
Application filed by Brandeis University filed Critical Brandeis University
Priority to PCT/US2013/070239 priority patent/WO2014078623A2/en
Priority to US14/440,978 priority patent/US9428589B2/en
Assigned to BRANDEIS UNIVERSITY reassignment BRANDEIS UNIVERSITY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: AGAR, JEFFREY N., SALISBURY, Joseph
Assigned to BRANDEIS UNIVERSITY reassignment BRANDEIS UNIVERSITY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: AGAR, JEFFREY, SALISBURY, Joseph
Publication of US20150284478A1 publication Critical patent/US20150284478A1/en
Publication of US9428589B2 publication Critical patent/US9428589B2/en
Application granted granted Critical
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links