US929610A - Commercial package of medicine. - Google Patents
Commercial package of medicine. Download PDFInfo
- Publication number
- US929610A US929610A US399890A US1907399890A US929610A US 929610 A US929610 A US 929610A US 399890 A US399890 A US 399890A US 1907399890 A US1907399890 A US 1907399890A US 929610 A US929610 A US 929610A
- Authority
- US
- United States
- Prior art keywords
- medicine
- oil
- package
- film
- bottle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 10
- 239000003921 oil Substances 0.000 description 10
- 239000010408 film Substances 0.000 description 9
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 8
- 235000011187 glycerol Nutrition 0.000 description 5
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000004277 Ferrous carbonate Substances 0.000 description 4
- 229960004652 ferrous carbonate Drugs 0.000 description 4
- 235000019268 ferrous carbonate Nutrition 0.000 description 4
- RAQDACVRFCEPDA-UHFFFAOYSA-L ferrous carbonate Chemical compound [Fe+2].[O-]C([O-])=O RAQDACVRFCEPDA-UHFFFAOYSA-L 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 229910000015 iron(II) carbonate Inorganic materials 0.000 description 4
- 229910000027 potassium carbonate Inorganic materials 0.000 description 4
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 3
- 229960001781 ferrous sulfate Drugs 0.000 description 3
- 239000011790 ferrous sulphate Substances 0.000 description 3
- 235000003891 ferrous sulphate Nutrition 0.000 description 3
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000009967 tasteless effect Effects 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- VNWKTOKETHGBQD-AKLPVKDBSA-N carbane Chemical compound [15CH4] VNWKTOKETHGBQD-AKLPVKDBSA-N 0.000 description 1
- 239000007799 cork Substances 0.000 description 1
- 229910052571 earthenware Inorganic materials 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000000346 nonvolatile oil Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- 239000004540 pour-on Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
- B65D81/22—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient in moist conditions or immersed in liquids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S206/00—Special receptacle or package
- Y10S206/828—Medicinal content
Definitions
- liquid pharmaceutical preparation consisting broadly of a ferrous salt, a carbonate, or its equivalent, and a liquid carrier for these two substances of such character as to prevent their combination into ferrous carbonate,
- my imprir-ed pharmaceutical pre )aration comprises specifically a mixture of ferroussulfate, potassium carbonate and glycerin, although of course it will be understood that any satisfactory ferrous salt may be substituted for the sulfate, any satisfactory alkaline carbonate, or other substance capable of furnishing the necessary CO group for the subsequent production of ferrous carbonate, may be substituted for the potassium carbonate, and any liquid carrier capable of holding the other ingredients in suspension so as to prevent the normal production of ferrous carbonate may be substituted for the glzycerin.
- any desirable form of package may be used but the ordinary bottle, such as is illustrated in the drawings, is probably the most satisfactory. scribed is delivered into the bottle so as to nearly fill the same and I add to this mixture at small quantity of a neutral non-volatile oil, conveniently a tasteless and colorless petroleum oil, in sufficient quantity to form a light film entirely over the top of the li uid'.
- a neutral non-volatile oil conveniently a tasteless and colorless petroleum oil
- the carbon dioxid gas remains in the bottle so long as the package is continued in its original condition, but of course disappears as soon as the bottle is uneorked and the first dose of medicine is taken.
- a dose of the medicine is only a small portion of the contents of the bottle and instructions are therefore given to shake Well before taking so that the film of protecting oil will be broken up and distributed in the body of the medicme.
- a dose is poured off under these conditions only a very small part of the 'oil passes out and as soon as the bottle is alowed to remain standing for a short time the oil gathers at the top of the medicine and again forms a protecting film which is substantially air and moisture tight, and therefore prevents the access of air and moisture to the medicine.
- a package of medicine comprising a vessel containlng a liquid medicine, a thin film of oil upon such medicine, a stop er, and a volume of carbon dioxid gas filling the space between the stopper and oil film.
- a package of medicine comprising a vessel containing a liquid medicine, a thin In witness whereof, I have hereunto set my hand and seal at Indiana )olis, Indiana, this twenty-sixth day of ()cto lxn', A. I). one 20 thousand nine hundred and seven.
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Description
J. K. LILLY. COMMERCIAL PACKAGE OF MEDICINE.
APPLICATION FILED 001230, 1907. Patented July 27, 1909.
witnesses )ZM/ifl UNITED STATES PATENT OFFICE.
' JOSIAH K. LILLY, OF INDIANAPOLIS, INDIANA, A'SSIGNOR TO ELI LILLY & COMPANY, OF INDIANAPOLIS, INDIANA, A CORPORATION OF INDIANA.
. CoMMEnCIAL PACKAGE OF MEDICINE.
Specification of Letters Patent.
' Patented July 27, 1909.
Original application tiled September 1, 1906, Serial No. 333,026. Divided and this application filed October 30, 1907. Serial No. 899,890.
To all whom it may concern:
Be it known that I, JosIAII Ix. LILLY, a citizen of" the United States, residing at In dianapolis, in the county of Marion and State v of Indiana, have invented certain new and useful Improvements in Commercial Packages of a Pharmaceutical Preparation, of which the following is a specification.
In the nt-anufacture and marketing of a liquid pharmaceutical preparation consisting broadly of a ferrous salt, a carbonate, or its equivalent, and a liquid carrier for these two substances of such character as to prevent their combination into ferrous carbonate,
and prevent their oxidation, and consisting specifically of a solution of ferrous sulfate and sodium carbonate in glycerin, it has been found that, in order that the preparation may retain its medicinal value for a long period, it is desirable to so package the preparation as to protect it while sealed and auto m atically protect it after it has been once unsealed. My present application, therefore,
. which is a division of my application Serial No. 333,026, filed September 1,1906, relates to the improved package for this pharmacew tical preparation.-
The accompanying drawing is a vertical section of a package embodying my invention;
As disclosed in the application before mentioned, my imprir-ed pharmaceutical pre )aration comprises specifically a mixture of ferroussulfate, potassium carbonate and glycerin, although of course it will be understood that any satisfactory ferrous salt may be substituted for the sulfate, any satisfactory alkaline carbonate, or other substance capable of furnishing the necessary CO group for the subsequent production of ferrous carbonate, may be substituted for the potassium carbonate, and any liquid carrier capable of holding the other ingredients in suspension so as to prevent the normal production of ferrous carbonate may be substituted for the glzycerin.
In ractice I have found that, for producg tfie medicine in commercial quantities, the following formula has been satisfactory. (a) In elevenv (11) gallons of pure glycerin dissolve, by aid of gentle heat, three (3) pounds, four (4) ounces, two hundred and rinety-two (292) grains of pure ferrous sulfate. (b) In four (4) gallons of pure glycerin dissolve, by aid of gentle heat,'one (1) pound,
ten (10) ounces, ninety (90) grains of pure potassium carbonate. (c) \Vhen cool, place solution (a) in an earthenware vessel. of sufficient capacity and add slowly, with stirring, solution (1)). When thoroughly mixed, pour on sufficient pure mineral'oil to cover the surface in order to protect from oxygen and moisture in the air, whereupon it is ready to be drawn off from below into bottles or other suitable packages. 7
Any desirable form of package may be used but the ordinary bottle, such as is illustrated in the drawings, is probably the most satisfactory. scribed is delivered into the bottle so as to nearly fill the same and I add to this mixture at small quantity of a neutral non-volatile oil, conveniently a tasteless and colorless petroleum oil, in sufficient quantity to form a light film entirely over the top of the li uid'.
Then, in order to further prevent any 5 ightreaction which might result from airv in the u )per end of the bottle during a long period ofstorage, either in thefactory or on a druggists shelves, I fill the space in the bottle, above the oil film, with carbon dioxid gas and then seal tightly by a cork or otherwise, as clearly indicated in the, drawing. The oil which is used as a film should preferably be tasteless and colorless, and the quantity relative to the medicine is quite small.
The carbon dioxid gas remains in the bottle so long as the package is continued in its original condition, but of course disappears as soon as the bottle is uneorked and the first dose of medicine is taken. A dose of the medicine is only a small portion of the contents of the bottle and instructions are therefore given to shake Well before taking so that the film of protecting oil will be broken up and distributed in the body of the medicme. When a dose is poured off under these conditions only a very small part of the 'oil passes out and as soon as the bottle is alowed to remain standing for a short time the oil gathers at the top of the medicine and again forms a protecting film which is substantially air and moisture tight, and therefore prevents the access of air and moisture to the medicine.
In the presenceof water the ferrous sul- The mixture hereinbefore de- 4 'fate and the potassium carbonate readily unite to form. the medicinal ferrous-carbonate and as 011 is desirable to serveas a protection against lycerin is hygroscopic the film of.
the absorption of water by the glycerin. film of non-volatile petroleum oil upon such This protection will continue so long as there i medicine, a stopper, and a volume of carbon 15 Is any medicine left in the package, the oil dioxid gas filling the space between the stopbeing sufiicient in quantity to continue to per and oil film.
form a thin film even for the last dose.
I claim as my invention:
1. A package of medicine comprising a vessel containlng a liquid medicine, a thin film of oil upon such medicine, a stop er, and a volume of carbon dioxid gas filling the space between the stopper and oil film.
2. A package of medicine comprising a vessel containing a liquid medicine, a thin In witness whereof, I have hereunto set my hand and seal at Indiana )olis, Indiana, this twenty-sixth day of ()cto lxn', A. I). one 20 thousand nine hundred and seven.
JOSIAH 1i. LILLY.
Witnesses:
ARTHUR M. H001), THOMAS W. McM EANS.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US399890A US929610A (en) | 1906-09-01 | 1907-10-30 | Commercial package of medicine. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33302606A US876366A (en) | 1906-09-01 | 1906-09-01 | Composition for the production of ferrous carbonate. |
| US399890A US929610A (en) | 1906-09-01 | 1907-10-30 | Commercial package of medicine. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US929610A true US929610A (en) | 1909-07-27 |
Family
ID=2998034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US399890A Expired - Lifetime US929610A (en) | 1906-09-01 | 1907-10-30 | Commercial package of medicine. |
Country Status (1)
| Country | Link |
|---|---|
| US (1) | US929610A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2803583A (en) * | 1952-10-16 | 1957-08-20 | Novo Terapeutisk Labor As | Aqueous suspensions of penicillin compounds exhibiting decreased caking on storage and maintained resuspendability |
| US4228893A (en) * | 1979-04-02 | 1980-10-21 | Ppg Industries, Inc. | Inhibition of paint-product skin formation on the interior surface of a paint vessel lid |
| US4426003A (en) | 1982-02-08 | 1984-01-17 | Jack Zarov | Drain cleaner package |
| US4867312A (en) * | 1988-10-17 | 1989-09-19 | Norton Company | Container sealing means for air and moisture sensitive materials |
| US5230427A (en) * | 1991-06-12 | 1993-07-27 | Ppg Industries, Inc. | Sterilizable hermetically-sealed substantially glass container |
-
1907
- 1907-10-30 US US399890A patent/US929610A/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2803583A (en) * | 1952-10-16 | 1957-08-20 | Novo Terapeutisk Labor As | Aqueous suspensions of penicillin compounds exhibiting decreased caking on storage and maintained resuspendability |
| US4228893A (en) * | 1979-04-02 | 1980-10-21 | Ppg Industries, Inc. | Inhibition of paint-product skin formation on the interior surface of a paint vessel lid |
| US4426003A (en) | 1982-02-08 | 1984-01-17 | Jack Zarov | Drain cleaner package |
| US4867312A (en) * | 1988-10-17 | 1989-09-19 | Norton Company | Container sealing means for air and moisture sensitive materials |
| US5230427A (en) * | 1991-06-12 | 1993-07-27 | Ppg Industries, Inc. | Sterilizable hermetically-sealed substantially glass container |
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