US8012098B2 - Determining a patient's posture from mechanical vibrations of the heart - Google Patents

Determining a patient's posture from mechanical vibrations of the heart Download PDF

Info

Publication number
US8012098B2
US8012098B2 US12484108 US48410809A US8012098B2 US 8012098 B2 US8012098 B2 US 8012098B2 US 12484108 US12484108 US 12484108 US 48410809 A US48410809 A US 48410809A US 8012098 B2 US8012098 B2 US 8012098B2
Authority
US
Grant status
Grant
Patent type
Prior art keywords
heart
patient
circuit
posture
sounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active, expires
Application number
US12484108
Other versions
US20090247889A1 (en )
Inventor
Keith R. Maile
Krzysztof Z. Siejko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cardiac Pacemakers Inc
Original Assignee
Cardiac Pacemakers Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362Heart stimulators
    • A61N1/365Heart stimulators controlled by a physiological parameter, e.g. heart potential
    • A61N1/36514Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
    • A61N1/36542Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by body motion, e.g. acceleration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B7/00Instruments for auscultation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362Heart stimulators
    • A61N1/365Heart stimulators controlled by a physiological parameter, e.g. heart potential
    • A61N1/36514Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
    • A61N1/36535Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by body position or posture
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362Heart stimulators
    • A61N1/365Heart stimulators controlled by a physiological parameter, e.g. heart potential
    • A61N1/36514Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
    • A61N1/36578Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by mechanical motion of the heart wall, e.g. measured by an accelerometer or microphone

Abstract

A system for determining a patient's posture by monitoring heart sounds. The system comprises an implantable medical device that includes a sensor operable to produce an electrical signal representative of heart sounds, a sensor interface circuit coupled to the sensor to produce a heart sound signal, and a controller circuit coupled to the sensor interface circuit. The heart sounds are associated with mechanical activity of a patient's heart and the controller circuit is operable to detect a posture of the patient from a heart sound signal.

Description

CLAIM OF PRIORITY

This application is a Divisional of U.S. application Ser. No. 10/900,570, filed Jul. 28, 2004, which is incorporated herein by reference in its entirety.

CROSS-REFERENCE TO RELATED APPLICATION

This application is related to commonly assigned U.S. patent application Ser. No. 10/703,175, entitled “A DUAL USE SENSOR FOR RATE RESPONSIVE PACING AND HEART SOUND MONITORING,” filed on Nov. 6, 2003, and U.S. patent application Ser. No. 10/334,694 entitled “METHOD AND APPARATUS FOR MONITORING OF DIASTOLIC HEMODYNAMICS,” filed on Dec. 30, 2002, which are hereby incorporated by reference.

TECHNICAL FIELD

The field generally relates to implantable medical devices and, in particular, but not by way of limitation, to systems and methods for determining a patient's posture by monitoring the mechanical functions of the heart.

BACKGROUND

Implantable medical devices (IMDs) are devices designed to be implanted into a patient. Some examples of these devices include cardiac rhythm management (CRM) devices such as implantable pacemakers and implantable cardioverter defibrillators (ICDs). The devices are used to treat patients using electrical therapy and to aid a physician or caregiver in patient diagnosis through internal monitoring of a patient's condition. Implantable devices may also include electrical leads that are either separate from, or connected to, a CRM. Electrical leads connected to CRM devices are located in or near a heart to provide electrical therapy to the heart. The electrical leads are also in communication with sense amplifiers of the CRM devices to monitor electrical heart activity within a patient. Other examples of implantable medical devices include implantable insulin pumps or devices implanted to administer drugs to a patient.

Congestive heart failure is a disease that causes the ventricles of the heart to have a reduced ability to contract which results in an inadequate amount of blood being pumped into circulation. Because blood is being pumped away from the lungs at a reduced rate, fluid may build up in a patient's lungs and cause difficulty in breathing. As a patient's condition worsens, the patient may develop a tendency to rest in an elevated posture to reduce the fluid buildup in his or her lungs. Some CRM devices provide electrical therapy to treat congestive heart failure. The present inventors have recognized a need for improved monitoring of the condition of a congestive heart failure patient.

SUMMARY

Systems and methods are provided for determining a patient's posture by monitoring heart sounds. In one system example, the system comprises an implantable medical device that includes a sensor operable to produce an electrical signal representative of heart sounds, a sensor interface circuit coupled to the sensor to produce a heart sound signal, and a controller circuit coupled to the sensor interface circuit. The heart sounds are associated with mechanical activity of a patient's heart and the controller circuit is operable to detect a posture of the patient from a heart sound signal.

In one method example, the method comprises sensing heart sounds associated with activity of a patient's heart using an implantable medical device and determining posture information of the patient from the heart sounds.

This summary is intended to provide an overview of the subject matter of the present patent application. It is not intended to provide an exclusive or exhaustive explanation of the invention. The detailed description is included to provide further information about the subject matter of the present patent application.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 illustrates an embodiment of a system that uses an implantable medical device.

FIG. 2 is a block diagram of an implantable medical device.

FIG. 3 is a graphical representation of S1 and S2 heart sound signals as a function of time.

FIG. 4 is a block diagram of another embodiment of an implantable medical device.

FIG. 5 is a block diagram of another embodiment of an implantable medical device.

FIG. 6 is a block diagram of another embodiment of an implantable medical device.

FIG. 7 is a block diagram of a method for determining posture of a patient.

DETAILED DESCRIPTION

In the following detailed description, reference is made to the accompanying drawings which form a part hereof, and specific embodiments in which the invention may be practiced are shown by way of illustration. It is to be understood that other embodiments may be used and structural or logical changes may be made without departing from the scope of the present invention.

The present application discusses, among other things, systems and methods for determining a patient's posture by monitoring heart sounds. Implantable medical devices (IMDs) may include sensors to monitor internal patient parameters. For example, an acoustic sensor can be used to sense heart sounds. Heart sounds are the sounds resulting from the physical contractions of the heart. Heart sound one (S1) occurs when a heart's ventricles receive blood from the atria. S1 is the sound made by the heart during the near simultaneous closure of the mitral and tricuspid valves. Heart sound two (S2) occurs when the ventricles are emptied. S2 is the sound made by the heart during the near simultaneous closure of the aortic and pulmonic valves. When a person is standing or sitting, the amplitude of the heart sounds and the frequency components of the heart sounds of the person are different than when the person is lying down. By monitoring the amplitude or the frequency spectrum of the heart sounds it can be determined whether the patient is laying down or is in an upright position.

FIG. 1 illustrates an embodiment of a system 100 that uses an IMD 110. The system 100 shown is one embodiment of portions of a system 100 used to treat a cardiac arrhythmia. A pulse generator (PG) or other IMD 110 is coupled by a cardiac lead 108, or additional leads, to a heart 105 of a patient 102. Examples of IMD 110 include, without limitation, a pacer, a defibrillator, a cardiac resynchronization therapy (CRT) device, or a combination of such devices. System 100 also includes an MD programmer or other external system 170 that provides wireless communication signals 160 to communicate with the IMD 110, such as by using telemetry or radio frequency (RF) signals.

Cardiac lead 108 includes a proximal end that is coupled to IMD 110 and a distal end, coupled by an electrode or electrodes to one or more portions of a heart 105. The electrodes are for delivering atrial and/or ventricular cardioversion/defibrillation and/or pacing or resynchronization therapy to the heart 105. IMD 110 includes components that are enclosed in a hermetically-sealed canister or “can.” Additional electrodes may be located on the can, or on an insulating header, or on other portions of IMD 110, for providing unipolar pacing and/or defibrillation energy in conjunction with the electrodes disposed on or around heart 105. The lead 108 or leads and electrodes are also used for sensing electrical activity of a heart 105.

FIG. 2 is a block diagram 200 of an embodiment of an implantable medical device (IMD) 210 used in a system for cardiac rhythm management. The IMD 210 includes a signal sensing circuit 212 to sense electrical signals on the lead or leads 108 and electrodes. To sense the electrical signals, the sensing circuit 212 includes sense amplifier circuits (not shown). The IMD 210 includes a pacing circuit 214 to deliver electrical therapy to a heart through the lead or leads 108 and electrodes. The electrical therapy includes altering a heart rate through electrical stimulation as well as re-synchronizing the depolarizations of heart chambers without necessarily altering a heart rate. Sensor 216 is operable to produce an electrical signal representative of heart sounds. In one embodiment, the sensor 216 is an accelerometer that senses vibrations associated with mechanical activity of a heart. The IMD 210 also includes a controller circuit 222 and memory circuit 224. Sensor interface circuit 218 is coupled to the sensor 216 and processes the sensor signal to produce a heart sound signal readable by controller circuit 222. The controller circuit 222 is operable to detect a posture of the patient from the heart sound signal, such as by executing an algorithm or algorithms implemented by hardware, software, firmware or any combination of hardware, software or firmware.

In some embodiments, the controller circuit 222 is operable to detect a posture of the patient from a frequency spectrum of the heart sound signal. The spectral energy of the S1 and S2 heart sounds are generally within a range of about 10 Hz to about 100 Hz. When a person changes from an upright position to a supine position, the spectral energy rolls off at a lower frequency, i.e. more high frequency components are attenuated. When a person changes from a supine to an upright position, more high frequency components appear. In one such embodiment, the controller circuit 222 is operable to perform a spectral analysis of energy of the heart sound signals to detect this change in the frequency spectrum of a patient. In another embodiment, the spectral analysis to detect the change in frequency includes a fast Fourier transform.

To detect a change in the frequency spectrum of the heart sound signal, in one embodiment the memory circuit 224 is operable to store a baseline frequency spectrum for the patient requiring the IMD 210. The baseline can be either for the upright or supine position. The controller circuit 222 then detects a change in the position by a comparison of the baseline frequency spectrum to the current frequency spectrum. The change can be either the addition of higher frequencies to a supine baseline or the subtraction of the higher frequencies from an upright baseline. In one embodiment, the baseline frequency spectrum is obtained from a personal profile of the patient. In another embodiment, the baseline frequency spectrum is obtained from a patient population.

In other embodiments, the controller circuit 222 is operable to detect a posture of the patient from an amplitude or magnitude of the heart sound signal. When a person is in a supine position, the S1 and S2 heart sounds are significantly smaller in amplitude than when the person is standing or sitting. FIG. 3 shows a graphical representation 300 of amplitudes of S1 and S2 heart sound signals as a function of time. The graph shows the time relationship between the heart sounds. To measure the heart sounds an S1 timing window 310 is begun to measure the S1 signal. The S1 window 310 is timed in relation to a ventricular event (not shown). After the S1 window expires an S2 timing window 320 is begun to measure the S2 heart sounds. In one embodiment, the S1 and S2 timing windows are taken or determined specifically for one patient. In another embodiment, the S1 and S2 timing windows are determined from a patient population.

Returning to FIG. 2, sensor interface circuit 218 provides a heart signal amplitude value to the controller circuit 222. In one embodiment, the controller circuit determines the posture of a patient from the amplitude value. In another embodiment, the IMD 210 detects a change in amplitude of the heart sound signal. In the embodiment, the memory circuit 224 is operable to store a baseline amplitude value that can be either for the upright or supine position. The controller circuit 222 then detects a change in the position by a comparison of the baseline amplitude to the current measured amplitude to determine a patient position from the change from the baseline amplitude. The comparison may involve a single maximum value, a central tendency maximum value such as a mean maximum value, or a morphology comparison.

In yet another embodiment, the presence of the higher frequencies or higher amplitudes is given a logical state by the controller circuit 222, such as a logical “1,” denoting that the higher frequencies or higher amplitudes are present and the person is upright. A logical “0” indicates that the higher frequencies or higher amplitudes are not present and the person is lying down. In yet another embodiment, the controller circuit 222 is operable to apply a weighing or scoring over a plurality of cardiac cycles before deeming that the patient is standing or supine. Such a scoring or weighing is useful to accommodate gradual changes in posture.

FIG. 4 is a block diagram 400 of another embodiment of an IMD 410. In the embodiment, the sensor 416 is an accelerometer and provides electrical signals representative of acceleration to the sensor processing circuit 418. The accelerometer detects mechanical vibrations of the heart that correspond to the S1 and S2 heart sounds. The sensor interface circuit 418 includes amplifier circuit 440 and low-pass filter circuit 442. The sensor interface circuit 418 provides a heart sound signal to controller circuit 422. The controller circuit 422 then detects a posture of the patient from the frequency spectrum or the amplitude of the heart sound signal. The controller circuit is operable to adjust the parameters of the amplifier circuit 440 and filter circuit 442. For example, in one embodiment, the amplifier circuit 440 provides a signal gain of one thousand. In another example, the controller circuit 422 adjusts the filter circuit 442 to single pole roll-off.

FIG. 5 is a block diagram of an IMD 510 that includes another embodiment of a sensor interface circuit 518. In addition to amplifier 540 and low pass filter 542, the embodiment includes an analog-to-digital converter circuit 544 to convert the heart sound signals from accelerometer 516 into digital values. The controller circuit 522 then determines a maximum value or values of the heart sound signal values and compares the maximum to a previously stored maximum or baseline to determine a posture of the patient.

Further embodiments of a sensor interface circuit used when monitoring the amplitude or magnitude of a heart sound signal include peak detector circuits and level detector circuits. FIG. 6 is a block diagram of an example of an IMD 610 where the sensor interface circuit 618 includes a peak detector circuit. The sensor shown is an accelerometer 616. The peak detector circuit includes a diode 646, capacitor 650 and switch 648. The peak detector circuit stores the peak value of a heart sound signal detected during the timing window onto capacitor 650. This peak amplitude value is converted to a digital value by analog-to-digital converter 644. The sampling rate of the analog-to-digital converter is controlled by the controller circuit 622. The digital value is then used to determine a posture of a patient by any of the methods discussed above.

Returning to FIG. 2, another embodiment of the IMD 210 includes a tilt sensor coupled to the controller circuit 222 in addition to the heart sound sensor 216. A tilt sensor measures DC acceleration in each of three main axes and provides electrical signals related to this acceleration. The tilt sensor signals are useful in deducing patient posture. However, deducing a patient's posture from the tilt sensor signals is complicated by not always knowing the orientation of an IMD in a patient. In this embodiment, the controller circuit 222 is operable to determine the posture of the patient by correlating the heart sound signals and the tilt sensor signals.

Determining a patient's posture is useful in treating patients suffering from congestive heart failure or in detecting that a patient is suffering from congestive heart failure. As discussed previously some cardiac rhythm management (CRM) devices provide electrical pacing therapy to both ventricles of a patient's heart to improve the efficacy of contractions of the ventricles. Knowing a patient's posture at rest may give an indication of the efficacy of the pacing therapy. For example, information that the patient is resting for extended periods in an increasingly upright position may indicate that the patient's condition is worsening. In addition, if the patient is not being treated for congestive heart failure it may be an indication that the patient is developing congestive heart failure. Thus combining a patient's posture with activity level provides useful information. In one embodiment, a patient's activity level is deduced using time of day. If a patient is an upright position during nighttime hours, it may indicate that the patient is sleeping in an upright position to ease his or her breathing. In one embodiment, the controller circuit 222 is operable to provide a congestive heart failure status indicator as a result of trending this information over time.

Sensors have been included in CRM devices to monitor a patient's activity. Indications of a patient's activity level are used to adjust a rate of pacing therapy of a CRM device. Generally, these CRM devices increase a pacing rate according to an algorithm based on the activity level of the patient indicated by the sensor. This is sometimes referred to as rate responsive pacing. An accelerometer is one type of sensor 216 that provides electrical signals representative of patient activity. If an accelerometer is also used to monitor heart sounds, the heart sound signals should be measured while the patient is at rest. Determining that a patient is at rest can be deduced from a patient's heart rate if the IMD 210 includes rate responsive pacing therapy—i.e. the patient's heart rate is at the resting heart rate.

In one embodiment, the IMD 210 includes a sensor to monitor patient activity and a sensor 216 to monitor heart sounds. In another embodiment, the sensor 216 is operable to produce electrical signals representative of both heart sounds and patient activity. A discussion of using a sensor to monitor both patient physical activity and heart sounds is found in the previously mentioned U.S. patent application Ser. No. 10/703,175, entitled “A DUAL USE SENSOR FOR RATE RESPONSIVE PACING AND HEART SOUND MONITORING,” which is incorporated herein by reference.

In yet other embodiments, information from posture at rest can also be combined with other sensor information to detect congestive heart failure. In one embodiment, the system to determine a patient's posture by monitoring heart sounds further includes a pressure sensor coupled to the IMD 210. The pressure sensor is located and operable to produce electrical signals related to thoracic pressure of a patient. An increase in thoracic pressure may indicate fluid buildup in a patient's lungs. The controller circuit 222 is operable to use both posture information and the pressure information to provide a congestive heart failure status indicator.

In another embodiment, the system further includes a transthoracic impedance measurement circuit coupled to the IMD 210. The transthoracic impedance measurement circuit is operable to measure impedance across a thorax of the patient. A decrease in thoracic impedance may indicate fluid buildup in a patient's lungs. In the embodiment, the controller circuit 222 is operable to use posture information and transthoracic impedance information to provide a congestive heart failure status indicator.

Other embodiments of a system to determine a patient's posture by monitoring heart sounds include an external device operable to communicate with the IMD 210. The IMD 210 includes a communication module, such as telemetry module 226, to transmit or receive information from the external device using wireless communication signals. In one embodiment, the external device includes a display to display patient posture information obtained using the heart sound signal. In another embodiment, the display of patient posture information includes a histogram of patient posture. In yet another embodiment, the display of patient posture information includes trending information of patient posture. For example, the trending information may include information that the patient is resting for extended periods in an upright condition. In some embodiments, the controller circuit 222 processes the heart sound information and transmits posture information to the external device. In other embodiments, the controller circuit 222 transmits heart sound information to the external device and the external device derives the posture information. In yet another embodiment, the external device is operable to communicate with a computer network such as, for example, a hospital network or global computer network such as the internet.

FIG. 7 is a block diagram 700 of a method for determining posture of a patient. At 710, heart sounds associated with activity of a patient's heart are sensed using an implantable medical device. At 720, posture information of the patient is determined from the heart sounds. In one embodiment, the posture information is determined using a frequency spectrum of the heart sounds. In another embodiment, the posture information is determined using a magnitude of the heart sounds.

The accompanying drawings that form a part hereof, show by way of illustration, and not of limitation, specific embodiments in which the subject matter may be practiced. The embodiments illustrated are described in sufficient detail to enable those skilled in the art to practice the teachings disclosed herein. Other embodiments may be utilized and derived therefrom, such that structural and logical substitutions and changes may be made without departing from the scope of this disclosure. This Detailed Description, therefore, is not to be taken in a limiting sense, and the scope of various embodiments is defined only by the appended claims, along with the full range of equivalents to which such claims are entitled.

Such embodiments of the inventive subject matter may be referred to herein, individually and/or collectively, by the term “invention” merely for convenience and without intending to voluntarily limit the scope of this application to any single invention or inventive concept if more than one is in fact disclosed. Thus, although specific embodiments have been illustrated and described herein, it should be appreciated that any arrangement calculated to achieve the same purpose may be substituted for the specific embodiments shown. This disclosure is intended to cover any and all adaptations, or variations, or combinations of various embodiments. Combinations of the above embodiments, and other embodiments not specifically described herein, will be apparent to those of skill in the art upon reviewing the above description.

The Abstract of the Disclosure is provided to comply with 37 C.F.R. §1.72(b), requiring an abstract that will allow the reader to quickly ascertain the nature of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. In addition, in the foregoing Detailed Description, it can be seen that various features are grouped together in a single embodiment for the purpose of streamlining the disclosure. This method of disclosure is not to be interpreted as reflecting an intention that the claimed embodiments require more features than are expressly recited in each claim. Rather, as the following claims reflect, inventive subject matter lies in less than all features of a single disclosed embodiment. Thus the following claims are hereby incorporated into the Detailed Description, with each claim standing on its own as a separate embodiment.

Claims (20)

1. A method comprising:
sensing heart sounds associated with activity of a patient's heart using an implantable medical device;
discriminating a posture of the patient from among a plurality of postures from the heart sounds; and
providing an indication of patient posture to a user or process.
2. The method of claim 1, wherein determining posture information of the patient from the heart sounds includes determining posture information from a frequency spectrum of the heart sounds.
3. The method of claim 2, wherein determining posture information from a frequency spectrum of the heart sounds includes performing a spectral analysis of energy of the heart sound signals to detect a change in the frequency spectrum.
4. The method of claim 3, wherein performing the spectral analysis includes calculating a fast Fourier transform.
5. The method of claim 1, wherein determining posture information of the patient from the heart sounds includes determining posture information from a magnitude of the heart sounds.
6. The method of claim 1, wherein determining posture information of the patient from the heart sounds includes:
determining a baseline for the heart sounds; and
detecting a change from the baseline.
7. The method of claim 1, wherein the method further includes detecting a change in posture.
8. The method of claim 1, wherein sensing heart sounds includes sensing one or a combination of S1 and S2 heart sounds.
9. The method of claim 8, wherein sensing heart sounds includes sensing heart sounds during a timing window, wherein a beginning of the timing window is determined in relation to a sensed cardiac event.
10. The method of claim 9, wherein sensing heart sounds during a timing window includes determining a patient specific timing window.
11. The method of claim 9, wherein sensing heart sounds during a timing window includes determining a timing window from data taken from a patient population.
12. The method of claim 1, wherein the method further includes:
determining patient physical activity information; and
determining a patient rest posture from the posture information and the activity information.
13. The method of claim 12, wherein determining patient physical activity information includes determining activity information using a heart rate of the patient.
14. The method of claim 12, wherein determining patient physical activity information includes sensing patient physical activity using an accelerometer.
15. The method of claim 12, determining patient physical activity information includes determining patient physical activity information from a same sensor used to sense heart sounds.
16. The method of claim 1, wherein the method further includes:
determining patient thoracic pressure information using the implantable medical device; and
using both the posture information and the thoracic pressure information to provide a congestive heart failure status indicator.
17. The method of claim 1, wherein the method further includes:
determining transthoracic impedance information using the implantable medical device; and
using both the posture information and the transthoracic impedance information to provide a congestive heart failure status indicator.
18. The method of claim 1, wherein sensing heart sounds includes sampling an electrical signal representative of the heart sounds and storing samples of the signal as heart sound data, and wherein determining posture information of the patient from the heart sounds includes transmitting the heart sound data from the implantable medical device to an external device and deriving posture information using the external device.
19. The method of claim 1, wherein sensing heart sounds includes sampling electrical signal representative of the heart sounds and storing samples of the signal as heart sound data, and wherein determining posture information of the patient from the heart sounds includes creating a histogram from the heart sound data.
20. The method of claim 1, wherein sensing heart sounds includes sampling an electrical signal representative of the heart sounds and storing samples of the signal as heart sound data, and wherein determining posture information of the patient from the heart sounds includes trending the heart sound data.
US12484108 2004-07-28 2009-06-12 Determining a patient's posture from mechanical vibrations of the heart Active 2025-04-21 US8012098B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10900570 US7559901B2 (en) 2004-07-28 2004-07-28 Determining a patient's posture from mechanical vibrations of the heart
US12484108 US8012098B2 (en) 2004-07-28 2009-06-12 Determining a patient's posture from mechanical vibrations of the heart

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12484108 US8012098B2 (en) 2004-07-28 2009-06-12 Determining a patient's posture from mechanical vibrations of the heart

Publications (2)

Publication Number Publication Date
US20090247889A1 true US20090247889A1 (en) 2009-10-01
US8012098B2 true US8012098B2 (en) 2011-09-06

Family

ID=35733297

Family Applications (2)

Application Number Title Priority Date Filing Date
US10900570 Active 2026-05-15 US7559901B2 (en) 2004-07-28 2004-07-28 Determining a patient's posture from mechanical vibrations of the heart
US12484108 Active 2025-04-21 US8012098B2 (en) 2004-07-28 2009-06-12 Determining a patient's posture from mechanical vibrations of the heart

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US10900570 Active 2026-05-15 US7559901B2 (en) 2004-07-28 2004-07-28 Determining a patient's posture from mechanical vibrations of the heart

Country Status (1)

Country Link
US (2) US7559901B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8491488B1 (en) 2010-10-01 2013-07-23 Blaufuss Medical Multimedia Laboratories, LLC Method and system for identifying cardiopulmonary findings by using a heart and lung sounds builder

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1290145B1 (en) * 2000-05-31 2005-11-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Three-dimensional skin model
US7226422B2 (en) * 2002-10-09 2007-06-05 Cardiac Pacemakers, Inc. Detection of congestion from monitoring patient response to a recumbent position
US8043213B2 (en) 2002-12-18 2011-10-25 Cardiac Pacemakers, Inc. Advanced patient management for triaging health-related data using color codes
US7468032B2 (en) 2002-12-18 2008-12-23 Cardiac Pacemakers, Inc. Advanced patient management for identifying, displaying and assisting with correlating health-related data
US8391989B2 (en) 2002-12-18 2013-03-05 Cardiac Pacemakers, Inc. Advanced patient management for defining, identifying and using predetermined health-related events
US20040122294A1 (en) 2002-12-18 2004-06-24 John Hatlestad Advanced patient management with environmental data
US20040122487A1 (en) 2002-12-18 2004-06-24 John Hatlestad Advanced patient management with composite parameter indices
US7983759B2 (en) 2002-12-18 2011-07-19 Cardiac Pacemakers, Inc. Advanced patient management for reporting multiple health-related parameters
US7972275B2 (en) 2002-12-30 2011-07-05 Cardiac Pacemakers, Inc. Method and apparatus for monitoring of diastolic hemodynamics
US8951205B2 (en) 2002-12-30 2015-02-10 Cardiac Pacemakers, Inc. Method and apparatus for detecting atrial filling pressure
US7378955B2 (en) * 2003-01-03 2008-05-27 Cardiac Pacemakers, Inc. System and method for correlating biometric trends with a related temporal event
US8396565B2 (en) 2003-09-15 2013-03-12 Medtronic, Inc. Automatic therapy adjustments
US7248923B2 (en) * 2003-11-06 2007-07-24 Cardiac Pacemakers, Inc. Dual-use sensor for rate responsive pacing and heart sound monitoring
US7115096B2 (en) 2003-12-24 2006-10-03 Cardiac Pacemakers, Inc. Third heart sound activity index for heart failure monitoring
US7559901B2 (en) 2004-07-28 2009-07-14 Cardiac Pacemakers, Inc. Determining a patient's posture from mechanical vibrations of the heart
US7387610B2 (en) 2004-08-19 2008-06-17 Cardiac Pacemakers, Inc. Thoracic impedance detection with blood resistivity compensation
US7662104B2 (en) 2005-01-18 2010-02-16 Cardiac Pacemakers, Inc. Method for correction of posture dependence on heart sounds
US7424321B2 (en) * 2005-05-24 2008-09-09 Cardiac Pacemakers, Inc. Systems and methods for multi-axis cardiac vibration measurements
US7922669B2 (en) 2005-06-08 2011-04-12 Cardiac Pacemakers, Inc. Ischemia detection using a heart sound sensor
US8790254B2 (en) * 2005-06-29 2014-07-29 St. Jude Medical Ab Medical device for determining the posture of patient
US8108034B2 (en) 2005-11-28 2012-01-31 Cardiac Pacemakers, Inc. Systems and methods for valvular regurgitation detection
US20070129641A1 (en) * 2005-12-01 2007-06-07 Sweeney Robert J Posture estimation at transitions between states
US7567836B2 (en) * 2006-01-30 2009-07-28 Cardiac Pacemakers, Inc. ECG signal power vector detection of ischemia or infarction
US7713213B2 (en) * 2006-03-13 2010-05-11 Cardiac Pacemakers, Inc. Physiological event detection systems and methods
US8920343B2 (en) 2006-03-23 2014-12-30 Michael Edward Sabatino Apparatus for acquiring and processing of physiological auditory signals
US7780606B2 (en) * 2006-03-29 2010-08-24 Cardiac Pacemakers, Inc. Hemodynamic stability assessment based on heart sounds
EP2010280A4 (en) * 2006-04-13 2009-12-02 St Jude Medical Medical device
US8000780B2 (en) * 2006-06-27 2011-08-16 Cardiac Pacemakers, Inc. Detection of myocardial ischemia from the time sequence of implanted sensor measurements
US8343049B2 (en) 2006-08-24 2013-01-01 Cardiac Pacemakers, Inc. Physiological response to posture change
US20080119749A1 (en) 2006-11-20 2008-05-22 Cardiac Pacemakers, Inc. Respiration-synchronized heart sound trending
US7736319B2 (en) 2007-01-19 2010-06-15 Cardiac Pacemakers, Inc. Ischemia detection using heart sound timing
US7853327B2 (en) 2007-04-17 2010-12-14 Cardiac Pacemakers, Inc. Heart sound tracking system and method
US20080294060A1 (en) * 2007-05-21 2008-11-27 Cardiac Pacemakers, Inc. Devices and methods for disease detection, monitoring and/or management
US8801636B2 (en) * 2007-07-19 2014-08-12 Cardiac Pacemakers, Inc. Method and apparatus for determining wellness based on decubitus posture
US7731658B2 (en) * 2007-08-16 2010-06-08 Cardiac Pacemakers, Inc. Glycemic control monitoring using implantable medical device
US8731665B1 (en) 2007-10-24 2014-05-20 Pacesetter, Inc. Posture detection using pressure and other physiologic sensors
US8447411B2 (en) 2008-07-11 2013-05-21 Medtronic, Inc. Patient interaction with posture-responsive therapy
US8231556B2 (en) 2008-07-11 2012-07-31 Medtronic, Inc. Obtaining baseline patient information
US8504150B2 (en) 2008-07-11 2013-08-06 Medtronic, Inc. Associating therapy adjustments with posture states using a stability timer
US9956412B2 (en) 2008-07-11 2018-05-01 Medtronic, Inc. Linking posture states for posture responsive therapy
US9440084B2 (en) 2008-07-11 2016-09-13 Medtronic, Inc. Programming posture responsive therapy
US8200340B2 (en) 2008-07-11 2012-06-12 Medtronic, Inc. Guided programming for posture-state responsive therapy
US9327129B2 (en) 2008-07-11 2016-05-03 Medtronic, Inc. Blended posture state classification and therapy delivery
US8708934B2 (en) 2008-07-11 2014-04-29 Medtronic, Inc. Reorientation of patient posture states for posture-responsive therapy
US9050471B2 (en) 2008-07-11 2015-06-09 Medtronic, Inc. Posture state display on medical device user interface
US8280517B2 (en) 2008-09-19 2012-10-02 Medtronic, Inc. Automatic validation techniques for validating operation of medical devices
US9026223B2 (en) 2009-04-30 2015-05-05 Medtronic, Inc. Therapy system including multiple posture sensors
US8175720B2 (en) 2009-04-30 2012-05-08 Medtronic, Inc. Posture-responsive therapy control based on patient input
US9327070B2 (en) 2009-04-30 2016-05-03 Medtronic, Inc. Medical device therapy based on posture and timing
US20110066042A1 (en) * 2009-09-15 2011-03-17 Texas Instruments Incorporated Estimation of blood flow and hemodynamic parameters from a single chest-worn sensor, and other circuits, devices and processes
US8579834B2 (en) 2010-01-08 2013-11-12 Medtronic, Inc. Display of detected patient posture state
US9149210B2 (en) 2010-01-08 2015-10-06 Medtronic, Inc. Automated calibration of posture state classification for a medical device
US9357949B2 (en) 2010-01-08 2016-06-07 Medtronic, Inc. User interface that displays medical therapy and posture data
US9956418B2 (en) 2010-01-08 2018-05-01 Medtronic, Inc. Graphical manipulation of posture zones for posture-responsive therapy
US9566441B2 (en) 2010-04-30 2017-02-14 Medtronic, Inc. Detecting posture sensor signal shift or drift in medical devices
JP2014502526A (en) 2010-12-15 2014-02-03 カーディアック ペースメイカーズ, インコーポレイテッド Heart decompensation detection using a plurality of sensors
US9332924B2 (en) 2010-12-15 2016-05-10 Cardiac Pacemakers, Inc. Posture detection using thoracic impedance
US9066659B2 (en) 2011-04-08 2015-06-30 Cardiac Pacemakers, Inc. Transient sensor response to posture as a measure of patient status
US20130023740A1 (en) * 2011-07-21 2013-01-24 Jens Kirchner Device and method for monitoring physiological signals
US9375152B2 (en) * 2012-03-07 2016-06-28 Cardiac Pacemakers, Inc. Heart sound detection systems and methods using updated heart sound expectation window functions
US9907959B2 (en) 2012-04-12 2018-03-06 Medtronic, Inc. Velocity detection for posture-responsive therapy
US9737719B2 (en) 2012-04-26 2017-08-22 Medtronic, Inc. Adjustment of therapy based on acceleration
US8909338B2 (en) 2012-07-25 2014-12-09 Cardiac Pacemakers, Inc. Electrode displacement detection
US9912612B2 (en) 2013-10-28 2018-03-06 Brocade Communications Systems LLC Extended ethernet fabric switches

Citations (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4094308A (en) 1976-08-19 1978-06-13 Cormier Cardiac Systems, Inc. Method and system for rapid non-invasive determination of the systolic time intervals
US4173971A (en) 1977-08-29 1979-11-13 Karz Allen E Continuous electrocardiogram monitoring method and system for cardiac patients
US4289141A (en) 1976-08-19 1981-09-15 Cormier Cardiac Systems, Inc. Method and apparatus for extracting systolic valvular events from heart sounds
US4428378A (en) 1981-11-19 1984-01-31 Medtronic, Inc. Rate adaptive pacer
US4446872A (en) 1977-09-08 1984-05-08 Avl Ag Method and apparatus for determining systolic time intervals
US4548204A (en) 1981-03-06 1985-10-22 Siemens Gammasonics, Inc. Apparatus for monitoring cardiac activity via ECG and heart sound signals
US4649930A (en) 1981-03-06 1987-03-17 Siemens Gammasonics, Inc. Apparatus for beat buffering techniques varified by arrhythmias detection for stopaction frames of cardiac function
US4763646A (en) 1985-10-04 1988-08-16 Siemens Aktiengesellschaft Heart pacemaker
US4773401A (en) 1987-08-21 1988-09-27 Cardiac Pacemakers, Inc. Physiologic control of pacemaker rate using pre-ejection interval as the controlling parameter
US4905706A (en) 1988-04-20 1990-03-06 Nippon Colin Co., Ltd. Method an apparatus for detection of heart disease
US4915113A (en) 1988-12-16 1990-04-10 Bio-Vascular, Inc. Method and apparatus for monitoring the patency of vascular grafts
US4989611A (en) 1988-08-19 1991-02-05 Seismed Instruments, Inc. Cardiac compression wave measuring system and method
US5159932A (en) 1990-03-16 1992-11-03 Seismed Instruments, Inc. Myocardial ischemia detection system
US5365932A (en) 1993-09-02 1994-11-22 Telectronics Pacing System, Inc. Cardiac signal sensing device having sensitivity automatically controlled in response to metabolic demand
US5472453A (en) 1992-04-03 1995-12-05 Intermedics, Inc. Medical interventional device with accelerometer for providing cardiac therapeutic functions
US5496361A (en) 1993-07-14 1996-03-05 Pacesetter, Inc. System and method for detecting cardiac arrhythmias using a cardiac wall acceleration sensor signal
US5593431A (en) 1995-03-30 1997-01-14 Medtronic, Inc. Medical service employing multiple DC accelerometers for patient activity and posture sensing and method
US5685317A (en) 1993-06-02 1997-11-11 Bang & Olufsen Technology A/S Apparatus for measuring cardiac signals, using acoustic and ecg signals
US5687738A (en) 1995-07-03 1997-11-18 The Regents Of The University Of Colorado Apparatus and methods for analyzing heart sounds
US5697375A (en) 1989-09-18 1997-12-16 The Research Foundation Of State University Of New York Method and apparatus utilizing heart sounds for determining pressures associated with the left atrium
US5704365A (en) 1994-11-14 1998-01-06 Cambridge Heart, Inc. Using related signals to reduce ECG noise
US5713355A (en) 1992-10-23 1998-02-03 Nellcor Puritan Bennett Incorporated Method and apparatus for reducing ambient noise effects in electronic monitoring instruments
US5725562A (en) 1995-03-30 1998-03-10 Medtronic Inc Rate responsive cardiac pacemaker and method for discriminating stair climbing from other activities
US5911738A (en) 1997-07-31 1999-06-15 Medtronic, Inc. High output sensor and accelerometer implantable medical device
US5991661A (en) 1997-10-17 1999-11-23 Pacesetter, Inc. System and method for measuring cardiac activity
US6009349A (en) 1993-11-16 1999-12-28 Pacesetter, Inc. System and method for deriving hemodynamic signals from a cardiac wall motion sensor
US6022963A (en) 1995-12-15 2000-02-08 Affymetrix, Inc. Synthesis of oligonucleotide arrays using photocleavable protecting groups
US6044297A (en) 1998-09-25 2000-03-28 Medtronic, Inc. Posture and device orientation and calibration for implantable medical devices
US6045513A (en) 1998-05-13 2000-04-04 Medtronic, Inc. Implantable medical device for tracking patient functional status
US6053872A (en) 1996-12-18 2000-04-25 Aurora Holdings, Llc Cardiac sonospectrographic analyzer
US6064910A (en) 1996-11-25 2000-05-16 Pacesetter Ab Respirator rate/respiration depth detector and device for monitoring respiratory activity employing same
US6076015A (en) 1998-02-27 2000-06-13 Cardiac Pacemakers, Inc. Rate adaptive cardiac rhythm management device using transthoracic impedance
US6077227A (en) 1998-12-28 2000-06-20 Medtronic, Inc. Method for manufacture and implant of an implantable blood vessel cuff
US6104949A (en) 1998-09-09 2000-08-15 Vitatron Medical, B.V. Medical device
US6152884A (en) 1996-04-25 2000-11-28 Bjoergaas; Per Samuel Method and instrument for examination of heart/arteries using microphones
US6251126B1 (en) 1998-04-23 2001-06-26 Medtronic Inc Method and apparatus for synchronized treatment of obstructive sleep apnea
US6264611B1 (en) 1998-11-25 2001-07-24 Ball Semiconductor, Inc. Monitor for interventional procedures
US6269269B1 (en) 1998-04-23 2001-07-31 Medtronic Inc. Method and apparatus for synchronized treatment of obstructive sleep apnea
US6272377B1 (en) 1999-10-01 2001-08-07 Cardiac Pacemakers, Inc. Cardiac rhythm management system with arrhythmia prediction and prevention
US6298269B1 (en) 1999-04-19 2001-10-02 Cardiac Pacemakers, Inc. Cardiac rhythm management system with ultrasound for autocapture or other applications
US6314323B1 (en) 1998-01-09 2001-11-06 Pacesetter Ab Heart stimulator determining cardiac output, by measuring the systolic pressure, for controlling the stimulation
US6312378B1 (en) 1999-06-03 2001-11-06 Cardiac Intelligence Corporation System and method for automated collection and analysis of patient information retrieved from an implantable medical device for remote patient care
EP1179317A2 (en) 2000-08-09 2002-02-13 Colin Corporation Heart-sound analyzing apparatus
US6351672B1 (en) 1999-07-22 2002-02-26 Pacesetter, Inc. System and method for modulating the pacing rate based on patient activity and position
US6366811B1 (en) 1998-10-13 2002-04-02 Cardiac Pacemakers, Inc. Extraction of hemodynamic pulse pressure from fluid and myocardial accelerations
US6368283B1 (en) 2000-09-08 2002-04-09 Institut De Recherches Cliniques De Montreal Method and apparatus for estimating systolic and mean pulmonary artery pressures of a patient
US6415033B1 (en) 1999-09-15 2002-07-02 Ilife Systems, Inc. Physiological condition monitors utilizing very low frequency acoustic signals
US20020107450A1 (en) 2001-02-07 2002-08-08 Colin Corporation Heart-sound detecting apparatus and heart-sound detecting method
US6440082B1 (en) 1999-09-30 2002-08-27 Medtronic Physio-Control Manufacturing Corp. Method and apparatus for using heart sounds to determine the presence of a pulse
EP1247485A1 (en) 2001-04-04 2002-10-09 Colin Corporation Continuous blood-pressure monitoring apparatus
US6466821B1 (en) 1999-12-08 2002-10-15 Pacesetter, Inc. AC/DC multi-axis accelerometer for determining patient activity and body position
US20020151812A1 (en) 2001-04-11 2002-10-17 Cardiac Pacemakers, Inc. Apparatus and method for outputting heart sounds
US6531907B2 (en) 1999-08-20 2003-03-11 Cardiac Pacemakers, Inc. Amplifier with common mode and offset correction
US20030055352A1 (en) 2000-02-23 2003-03-20 Hayek Carleton S. System and method for diagnosing pathologic heart conditions
US20030093003A1 (en) 1999-09-29 2003-05-15 Raymond Watrous Multi-modal cardiac diagnostic decision support system and method
US20030093002A1 (en) 2001-11-13 2003-05-15 Kuo Terry B.J. Function indicator for autonomic nervous system based on phonocardiogram
US6567700B1 (en) 2000-10-19 2003-05-20 Robert Turcott Implantable cardiac stimulation device and method which optimizes pacing effectiveness
US20030105497A1 (en) 2001-12-03 2003-06-05 Cardiac Pacemakers, Inc. Implantable cardiac disease management device with trigger-stored polysomnogram and phonocardiogram
US20030176896A1 (en) 2002-03-13 2003-09-18 Lincoln William C. Cardiac rhythm management system and method using time between mitral valve closure and aortic ejection
US6625493B2 (en) 2001-08-24 2003-09-23 Pacesetter, Inc. Orientation of patient's position sensor using external field
US6650940B1 (en) 2000-02-02 2003-11-18 Cardiac Pacemakers, Inc. Accelerometer-based heart sound detection for autocapture
US20030216620A1 (en) 2002-05-15 2003-11-20 Mudit Jain Cardiac rhythm management systems and methods using acoustic contractility indicator
US6658292B2 (en) 2001-08-24 2003-12-02 Pacesetter, Inc. Detection of patient's position and activity status using 3D accelerometer-based position sensor
US20030229289A1 (en) 2002-03-18 2003-12-11 Mohler Sailor Hampton Method and system for generating a likelihood of cardiovascular disease, analyzing cardiovascular sound signals remotely from the location of cardiovascular sound signal acquisition, and determining time and phase information from cardiovascular sound signals
US6665564B2 (en) 2001-05-21 2003-12-16 Cardiac Pacemakers, Inc. Cardiac rhythm management system selecting A-V delay based on interval between atrial depolarization and mitral valve closure
US20030233132A1 (en) 2002-06-14 2003-12-18 Pastore Joseph M. Method and apparatus for detecting oscillations in cardiac rhythm
US20040039419A1 (en) 1999-09-30 2004-02-26 Stickney Ronald E. Apparatus, software, and methods for cardiac pulse detection using a piezoelectric sensor
US20040039420A1 (en) 2002-08-26 2004-02-26 Medtronic Physio-Control Manufacturing Corp. Apparatus, software, and methods for cardiac pulse detection using accelerometer data
US20040064056A1 (en) 2001-02-07 2004-04-01 Colin Corporation Heart-sound detecting apparatus and heart-sound detecting method
US6719701B2 (en) 2002-01-28 2004-04-13 Pacesetter, Inc. Implantable syncope monitor and method of using the same
US20040073093A1 (en) 2002-10-11 2004-04-15 Cardiac Pacemakers, Inc. Methods and devices for detection of context when addressing a medical condition of a patient
US20040078060A1 (en) 1998-05-08 2004-04-22 Cardiac Pacemakers, Inc. Cardiac pacing using adjustable atrio-ventricular delays
US20040106962A1 (en) 2000-07-28 2004-06-03 Junyu Mai Implantable stimulation device and method for adjusting AV/PV delay according to patient's posture
US20040111040A1 (en) 2002-12-04 2004-06-10 Quan Ni Detection of disordered breathing
US6752765B1 (en) 1999-12-01 2004-06-22 Medtronic, Inc. Method and apparatus for monitoring heart rate and abnormal respiration
US20040127792A1 (en) 2002-12-30 2004-07-01 Siejko Krzysztof Z. Method and apparatus for monitoring of diastolic hemodynamics
US20040138572A1 (en) 2001-05-28 2004-07-15 Arvind Thiagarajan Heart diagnosis system
US20040167417A1 (en) 2003-02-26 2004-08-26 Schulhauser Randal C. Apparatus and method for chronically monitoring heart sounds for deriving estimated blood pressure
US6795732B2 (en) 2001-10-30 2004-09-21 Medtronic, Inc. Implantable medical device employing sonomicrometer output signals for detection and measurement of cardiac mechanical function
US6810284B1 (en) 2001-11-21 2004-10-26 Pacesetter, Inc. Implantable cardiac stimulation system and method for monitoring diastolic function
US20040215264A1 (en) 2003-04-23 2004-10-28 Van Bentem Maarten Detecting heart tones to identify heart deterioration
US20040215265A1 (en) 2003-04-23 2004-10-28 Keizer Diederick M. Sensing techniques for implantable medical devices
US20040225332A1 (en) 2003-05-09 2004-11-11 Ursula Gebhardt Use of accelerometer signal to augment ventricular arrhythmia detection
US20040230243A1 (en) 2003-04-11 2004-11-18 Paul Haefner Noise canceling cardiac electrodes
US20040236239A1 (en) 2001-07-31 2004-11-25 Jim Murray Monitoring device
US6824519B2 (en) 2001-06-20 2004-11-30 Colin Medical Technology Corporation Heart-sound detecting apparatus
US6830548B2 (en) 2001-09-24 2004-12-14 Ela Medical S.A. Active medical device able to diagnose a patient respiratory profile
US20040254481A1 (en) 2003-06-13 2004-12-16 Ge Medical Systems Information Technologies, Inc. Methods and systems for monitoring respiration
US20040267148A1 (en) 2003-06-27 2004-12-30 Patricia Arand Method and system for detection of heart sounds
US20040267147A1 (en) 2001-01-25 2004-12-30 Sullivan Colin Edward Determining heart rate
US6845263B2 (en) 2000-02-18 2005-01-18 Colin Medical Technology Corporation Heart-sound detecting apparatus and pulse-wave-propagation-velocity-relating-information obtaining system using the heart-sound detecting apparatus
US20050027323A1 (en) 2001-10-30 2005-02-03 Medtronic, Inc. Implantable medical device for monitoring cardiac blood pressure and chamber dimension
US20050033190A1 (en) 2003-08-06 2005-02-10 Inovise Medical, Inc. Heart-activity monitoring with multi-axial audio detection
US20050060001A1 (en) 2003-09-15 2005-03-17 Ruchika Singhal Automatic therapy adjustments
US20050149136A1 (en) 2003-12-24 2005-07-07 Siejko Krzysztof Z. Third heart sound activity index for heart failure monitoring
US20050148897A1 (en) 2003-12-24 2005-07-07 Cho Yong K. Implantable medical device with sleep disordered breathing monitoring
US20050148896A1 (en) 2003-12-24 2005-07-07 Siejko Krzysztof Z. Method and apparatus for third heart sound detection
US20060020295A1 (en) 2004-07-23 2006-01-26 Cardiac Pacemakers, Inc. Method and apparatus for monitoring heart failure patients with cardiopulmonary comorbidities
US20060025699A1 (en) 2004-07-28 2006-02-02 Cardiac Pacemakers, Inc. Determining a patient's posture from mechanical vibrations of the heart
US20060041280A1 (en) 2004-08-19 2006-02-23 Cardiac Pacemakers, Inc. Thoracic impedance detection with blood resistivity compensation
US20060161070A1 (en) 2005-01-18 2006-07-20 Cardiac Pacemakers, Inc. Method for correction of posture dependence on heart sounds
US20060270939A1 (en) 2005-05-24 2006-11-30 Cardiac Pacemakers, Inc. Systems and methods for multi-axis cardiac vibration measurements
US7403813B1 (en) 2004-11-24 2008-07-22 Pacesetter, Inc. Systems and methods for detection of VT and VF from remote sensing electrodes

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4830006B1 (en) 1986-06-17 1997-10-28 Intermedics Inc Implantable cardiac stimulator for detection and treatment of ventricular arrhythmias
US4777960A (en) 1986-08-18 1988-10-18 Massachusetts Institute Of Technology Method and apparatus for the assessment of autonomic response by broad-band excitation
CA1327838C (en) 1988-06-13 1994-03-15 Fred Zacouto Implantable device to prevent blood clotting disorders
CA2033765C (en) 1990-03-08 1999-10-19 Brian D. Pederson Variation in cardiac chamber volume or pressure as a controlling parameter
US5097831A (en) 1990-04-16 1992-03-24 Siemens-Pacesetter, Inc. Rate-responsive pacemaker with circuitry for processing multiple sensor inputs
US5321618A (en) 1990-05-29 1994-06-14 Lawrence Gessman Apparatus and method for remotely monitoring implanted cardioverter defibrillators
US5226413A (en) 1990-08-14 1993-07-13 Medtronic, Inc. Rate responsive pacemaker and method for automatically initializing the same
US5113869A (en) 1990-08-21 1992-05-19 Telectronics Pacing Systems, Inc. Implantable ambulatory electrocardiogram monitor
US5179947A (en) 1991-01-15 1993-01-19 Cardiac Pacemakers, Inc. Acceleration-sensitive cardiac pacemaker and method of operation
US5205283A (en) 1991-07-30 1993-04-27 Medtronic, Inc. Method and apparatus for tachyarrhythmia detection and treatment
US5411531A (en) 1993-09-23 1995-05-02 Medtronic, Inc. Method and apparatus for control of A-V interval
US5549654A (en) 1994-04-15 1996-08-27 Medtronic, Inc. Interactive interpretation of event markers in body-implantable medical device
US5549650A (en) 1994-06-13 1996-08-27 Pacesetter, Inc. System and method for providing hemodynamically optimal pacing therapy
US5554177A (en) 1995-03-27 1996-09-10 Medtronic, Inc. Method and apparatus to optimize pacing based on intensity of acoustic signal
US5836987A (en) 1995-11-15 1998-11-17 Cardiac Pacemakers, Inc. Apparatus and method for optimizing cardiac performance by determining the optimal timing interval from an accelerometer signal
US5674256A (en) 1995-12-19 1997-10-07 Cardiac Pacemakers, Inc. Cardiac pre-ejection period detection
US6208900B1 (en) 1996-03-28 2001-03-27 Medtronic, Inc. Method and apparatus for rate-responsive cardiac pacing using header mounted pressure wave transducer
WO1998014239A1 (en) 1996-09-30 1998-04-09 Pacesetter Ab An implantable medical device comprising an accelerometer
US5700283A (en) 1996-11-25 1997-12-23 Cardiac Pacemakers, Inc. Method and apparatus for pacing patients with severe congestive heart failure
US5792195A (en) 1996-12-16 1998-08-11 Cardiac Pacemakers, Inc. Acceleration sensed safe upper rate envelope for calculating the hemodynamic upper rate limit for a rate adaptive cardiac rhythm management device
DE19711058A1 (en) 1997-03-03 1998-09-10 Biotronik Mess & Therapieg Apparatus for determining the AV conduction time
US5951593A (en) 1997-08-29 1999-09-14 Lu; Richard Apparatus for preventing atrial fibrillation using precursors
US6193668B1 (en) 1997-11-10 2001-02-27 Medacoustics, Inc. Acoustic sensor array for non-invasive detection of coronary artery disease
US5935081A (en) 1998-01-20 1999-08-10 Cardiac Pacemakers, Inc. Long term monitoring of acceleration signals for optimization of pacing therapy
US6048319A (en) 1998-10-01 2000-04-11 Integrated Medical Systems, Inc. Non-invasive acoustic screening device for coronary stenosis
US6044298A (en) 1998-10-13 2000-03-28 Cardiac Pacemakers, Inc. Optimization of pacing parameters based on measurement of integrated acoustic noise
US6115630A (en) 1999-03-29 2000-09-05 Medtronic, Inc. Determination of orientation of electrocardiogram signal in implantable medical devices
US6324421B1 (en) 1999-03-29 2001-11-27 Medtronic, Inc. Axis shift analysis of electrocardiogram signal parameters especially applicable for multivector analysis by implantable medical devices, and use of same
US6115628A (en) 1999-03-29 2000-09-05 Medtronic, Inc. Method and apparatus for filtering electrocardiogram (ECG) signals to remove bad cycle information and for use of physiologic signals determined from said filtered ECG signals
US6190324B1 (en) 1999-04-28 2001-02-20 Medtronic, Inc. Implantable medical device for tracking patient cardiac status
US6804558B2 (en) 1999-07-07 2004-10-12 Medtronic, Inc. System and method of communicating between an implantable medical device and a remote computer system or health care provider
US6687547B2 (en) 1999-09-14 2004-02-03 Medtronic, Inc. Method and apparatus for communicating with an implantable medical device with DTMF tones
US7127290B2 (en) 1999-10-01 2006-10-24 Cardiac Pacemakers, Inc. Cardiac rhythm management systems and methods predicting congestive heart failure status
US6273856B1 (en) 1999-10-19 2001-08-14 Cardiac Pacemakers, Inc. Apparatus and methods for METS measurement by accelerometer and minute ventilation sensors
US6275727B1 (en) 1999-11-04 2001-08-14 Cardiac Pacemakers, Inc. Implantable cardiac rhythm management device for assessing status of CHF patients
US6491639B1 (en) 1999-11-10 2002-12-10 Pacesetter, Inc. Extravascular hemodynamic sensor
US6527729B1 (en) 1999-11-10 2003-03-04 Pacesetter, Inc. Method for monitoring patient using acoustic sensor
US6477406B1 (en) 1999-11-10 2002-11-05 Pacesetter, Inc. Extravascular hemodynamic acoustic sensor
US6368284B1 (en) 1999-11-16 2002-04-09 Cardiac Intelligence Corporation Automated collection and analysis patient care system and method for diagnosing and monitoring myocardial ischemia and outcomes thereof
US6602191B2 (en) 1999-12-17 2003-08-05 Q-Tec Systems Llp Method and apparatus for health and disease management combining patient data monitoring with wireless internet connectivity
JP4352558B2 (en) 2000-02-18 2009-10-28 オムロンヘルスケア株式会社 Heart sound detector, and pre-ejection period measuring device, pulse-wave-propagation-velocity-related-information obtaining device using the heart sound detector
US6575916B2 (en) 2000-03-24 2003-06-10 Ilife Solutions, Inc. Apparatus and method for detecting very low frequency acoustic signals
US6643548B1 (en) 2000-04-06 2003-11-04 Pacesetter, Inc. Implantable cardiac stimulation device for monitoring heart sounds to detect progression and regression of heart disease and method thereof
US7261690B2 (en) 2000-06-16 2007-08-28 Bodymedia, Inc. Apparatus for monitoring health, wellness and fitness
KR100387201B1 (en) 2000-11-16 2003-06-12 이병훈 Diaortic apparatus
US6522923B1 (en) 2001-02-09 2003-02-18 Pacesetter, Inc. Methods, systems and devices for optimizing cardiac pacing parameters using evolutionary algorithms
US7181268B2 (en) * 2001-12-03 2007-02-20 Medtronic, Inc. Ischemia detection
US7248923B2 (en) 2003-11-06 2007-07-24 Cardiac Pacemakers, Inc. Dual-use sensor for rate responsive pacing and heart sound monitoring
US7736319B2 (en) * 2007-01-19 2010-06-15 Cardiac Pacemakers, Inc. Ischemia detection using heart sound timing

Patent Citations (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4094308A (en) 1976-08-19 1978-06-13 Cormier Cardiac Systems, Inc. Method and system for rapid non-invasive determination of the systolic time intervals
US4289141A (en) 1976-08-19 1981-09-15 Cormier Cardiac Systems, Inc. Method and apparatus for extracting systolic valvular events from heart sounds
US4173971A (en) 1977-08-29 1979-11-13 Karz Allen E Continuous electrocardiogram monitoring method and system for cardiac patients
US4446872A (en) 1977-09-08 1984-05-08 Avl Ag Method and apparatus for determining systolic time intervals
US4548204A (en) 1981-03-06 1985-10-22 Siemens Gammasonics, Inc. Apparatus for monitoring cardiac activity via ECG and heart sound signals
US4649930A (en) 1981-03-06 1987-03-17 Siemens Gammasonics, Inc. Apparatus for beat buffering techniques varified by arrhythmias detection for stopaction frames of cardiac function
US4428378A (en) 1981-11-19 1984-01-31 Medtronic, Inc. Rate adaptive pacer
US4763646A (en) 1985-10-04 1988-08-16 Siemens Aktiengesellschaft Heart pacemaker
US4773401A (en) 1987-08-21 1988-09-27 Cardiac Pacemakers, Inc. Physiologic control of pacemaker rate using pre-ejection interval as the controlling parameter
US4905706A (en) 1988-04-20 1990-03-06 Nippon Colin Co., Ltd. Method an apparatus for detection of heart disease
US4989611A (en) 1988-08-19 1991-02-05 Seismed Instruments, Inc. Cardiac compression wave measuring system and method
US4915113A (en) 1988-12-16 1990-04-10 Bio-Vascular, Inc. Method and apparatus for monitoring the patency of vascular grafts
US5697375A (en) 1989-09-18 1997-12-16 The Research Foundation Of State University Of New York Method and apparatus utilizing heart sounds for determining pressures associated with the left atrium
US5159932A (en) 1990-03-16 1992-11-03 Seismed Instruments, Inc. Myocardial ischemia detection system
US5472453A (en) 1992-04-03 1995-12-05 Intermedics, Inc. Medical interventional device with accelerometer for providing cardiac therapeutic functions
US5713355A (en) 1992-10-23 1998-02-03 Nellcor Puritan Bennett Incorporated Method and apparatus for reducing ambient noise effects in electronic monitoring instruments
US5685317A (en) 1993-06-02 1997-11-11 Bang & Olufsen Technology A/S Apparatus for measuring cardiac signals, using acoustic and ecg signals
US5496361A (en) 1993-07-14 1996-03-05 Pacesetter, Inc. System and method for detecting cardiac arrhythmias using a cardiac wall acceleration sensor signal
US5365932A (en) 1993-09-02 1994-11-22 Telectronics Pacing System, Inc. Cardiac signal sensing device having sensitivity automatically controlled in response to metabolic demand
US6009349A (en) 1993-11-16 1999-12-28 Pacesetter, Inc. System and method for deriving hemodynamic signals from a cardiac wall motion sensor
US5704365A (en) 1994-11-14 1998-01-06 Cambridge Heart, Inc. Using related signals to reduce ECG noise
US5593431A (en) 1995-03-30 1997-01-14 Medtronic, Inc. Medical service employing multiple DC accelerometers for patient activity and posture sensing and method
US5725562A (en) 1995-03-30 1998-03-10 Medtronic Inc Rate responsive cardiac pacemaker and method for discriminating stair climbing from other activities
EP0762908B1 (en) 1995-03-30 2003-05-21 Medtronic, Inc. Medical device employing multiple dc accelerometers for patient activity and posture sensing
US5687738A (en) 1995-07-03 1997-11-18 The Regents Of The University Of Colorado Apparatus and methods for analyzing heart sounds
US6022963A (en) 1995-12-15 2000-02-08 Affymetrix, Inc. Synthesis of oligonucleotide arrays using photocleavable protecting groups
US6152884A (en) 1996-04-25 2000-11-28 Bjoergaas; Per Samuel Method and instrument for examination of heart/arteries using microphones
US6064910A (en) 1996-11-25 2000-05-16 Pacesetter Ab Respirator rate/respiration depth detector and device for monitoring respiratory activity employing same
US20030120159A1 (en) 1996-12-18 2003-06-26 Mohler Sailor H. System and method of detecting and processing physiological sounds
US6053872A (en) 1996-12-18 2000-04-25 Aurora Holdings, Llc Cardiac sonospectrographic analyzer
US5911738A (en) 1997-07-31 1999-06-15 Medtronic, Inc. High output sensor and accelerometer implantable medical device
US5991661A (en) 1997-10-17 1999-11-23 Pacesetter, Inc. System and method for measuring cardiac activity
US6314323B1 (en) 1998-01-09 2001-11-06 Pacesetter Ab Heart stimulator determining cardiac output, by measuring the systolic pressure, for controlling the stimulation
US6076015A (en) 1998-02-27 2000-06-13 Cardiac Pacemakers, Inc. Rate adaptive cardiac rhythm management device using transthoracic impedance
US6269269B1 (en) 1998-04-23 2001-07-31 Medtronic Inc. Method and apparatus for synchronized treatment of obstructive sleep apnea
US6251126B1 (en) 1998-04-23 2001-06-26 Medtronic Inc Method and apparatus for synchronized treatment of obstructive sleep apnea
US20040078060A1 (en) 1998-05-08 2004-04-22 Cardiac Pacemakers, Inc. Cardiac pacing using adjustable atrio-ventricular delays
US20040078059A1 (en) 1998-05-08 2004-04-22 Cardiac Pacemakers, Inc. Cardiac pacing using adjustable atrio-ventricular delays
US6045513A (en) 1998-05-13 2000-04-04 Medtronic, Inc. Implantable medical device for tracking patient functional status
US6104949A (en) 1998-09-09 2000-08-15 Vitatron Medical, B.V. Medical device
US6044297A (en) 1998-09-25 2000-03-28 Medtronic, Inc. Posture and device orientation and calibration for implantable medical devices
US6366811B1 (en) 1998-10-13 2002-04-02 Cardiac Pacemakers, Inc. Extraction of hemodynamic pulse pressure from fluid and myocardial accelerations
US6264611B1 (en) 1998-11-25 2001-07-24 Ball Semiconductor, Inc. Monitor for interventional procedures
US6077227A (en) 1998-12-28 2000-06-20 Medtronic, Inc. Method for manufacture and implant of an implantable blood vessel cuff
US20020082645A1 (en) 1999-04-19 2002-06-27 Cardiac Pacemakers, Inc. Cardiac rhythm management system with ultrasound for autocapture or other applications
US6298269B1 (en) 1999-04-19 2001-10-02 Cardiac Pacemakers, Inc. Cardiac rhythm management system with ultrasound for autocapture or other applications
US20030069608A1 (en) 1999-04-19 2003-04-10 Cardiac Pacemakers, Inc. Cardiac rhythm management system with ultrasound for autocapture or other applications
US6312378B1 (en) 1999-06-03 2001-11-06 Cardiac Intelligence Corporation System and method for automated collection and analysis of patient information retrieved from an implantable medical device for remote patient care
US6351672B1 (en) 1999-07-22 2002-02-26 Pacesetter, Inc. System and method for modulating the pacing rate based on patient activity and position
US6531907B2 (en) 1999-08-20 2003-03-11 Cardiac Pacemakers, Inc. Amplifier with common mode and offset correction
US6415033B1 (en) 1999-09-15 2002-07-02 Ilife Systems, Inc. Physiological condition monitors utilizing very low frequency acoustic signals
US20030072458A1 (en) 1999-09-15 2003-04-17 Ilife Solutions, Inc. Physiological condition monitors utilizing very low frequency acoustic signals
US20030093003A1 (en) 1999-09-29 2003-05-15 Raymond Watrous Multi-modal cardiac diagnostic decision support system and method
US20040039419A1 (en) 1999-09-30 2004-02-26 Stickney Ronald E. Apparatus, software, and methods for cardiac pulse detection using a piezoelectric sensor
US6440082B1 (en) 1999-09-30 2002-08-27 Medtronic Physio-Control Manufacturing Corp. Method and apparatus for using heart sounds to determine the presence of a pulse
US6272377B1 (en) 1999-10-01 2001-08-07 Cardiac Pacemakers, Inc. Cardiac rhythm management system with arrhythmia prediction and prevention
US6752765B1 (en) 1999-12-01 2004-06-22 Medtronic, Inc. Method and apparatus for monitoring heart rate and abnormal respiration
US6466821B1 (en) 1999-12-08 2002-10-15 Pacesetter, Inc. AC/DC multi-axis accelerometer for determining patient activity and body position
US6650940B1 (en) 2000-02-02 2003-11-18 Cardiac Pacemakers, Inc. Accelerometer-based heart sound detection for autocapture
US6845263B2 (en) 2000-02-18 2005-01-18 Colin Medical Technology Corporation Heart-sound detecting apparatus and pulse-wave-propagation-velocity-relating-information obtaining system using the heart-sound detecting apparatus
US20030055352A1 (en) 2000-02-23 2003-03-20 Hayek Carleton S. System and method for diagnosing pathologic heart conditions
US20040106962A1 (en) 2000-07-28 2004-06-03 Junyu Mai Implantable stimulation device and method for adjusting AV/PV delay according to patient's posture
EP1179317A2 (en) 2000-08-09 2002-02-13 Colin Corporation Heart-sound analyzing apparatus
US20020035337A1 (en) 2000-08-09 2002-03-21 Colin Corporation Heart-sound analyzing apparatus
US6368283B1 (en) 2000-09-08 2002-04-09 Institut De Recherches Cliniques De Montreal Method and apparatus for estimating systolic and mean pulmonary artery pressures of a patient
US6567700B1 (en) 2000-10-19 2003-05-20 Robert Turcott Implantable cardiac stimulation device and method which optimizes pacing effectiveness
US20040267147A1 (en) 2001-01-25 2004-12-30 Sullivan Colin Edward Determining heart rate
US20020107450A1 (en) 2001-02-07 2002-08-08 Colin Corporation Heart-sound detecting apparatus and heart-sound detecting method
US20040064056A1 (en) 2001-02-07 2004-04-01 Colin Corporation Heart-sound detecting apparatus and heart-sound detecting method
US20020147401A1 (en) 2001-04-04 2002-10-10 Colin Corporation Continuous blood-pressure monitoring apparatus
EP1247485A1 (en) 2001-04-04 2002-10-09 Colin Corporation Continuous blood-pressure monitoring apparatus
US20020151812A1 (en) 2001-04-11 2002-10-17 Cardiac Pacemakers, Inc. Apparatus and method for outputting heart sounds
US6665564B2 (en) 2001-05-21 2003-12-16 Cardiac Pacemakers, Inc. Cardiac rhythm management system selecting A-V delay based on interval between atrial depolarization and mitral valve closure
US20040024423A1 (en) 2001-05-21 2004-02-05 Cardiac Pacemakers, Inc. Cardiac rhythm management system selecting A-V delay based on interval between atrial depolarization and mitral valve closure
US20040138572A1 (en) 2001-05-28 2004-07-15 Arvind Thiagarajan Heart diagnosis system
US6824519B2 (en) 2001-06-20 2004-11-30 Colin Medical Technology Corporation Heart-sound detecting apparatus
US20040236239A1 (en) 2001-07-31 2004-11-25 Jim Murray Monitoring device
US6658292B2 (en) 2001-08-24 2003-12-02 Pacesetter, Inc. Detection of patient's position and activity status using 3D accelerometer-based position sensor
US6625493B2 (en) 2001-08-24 2003-09-23 Pacesetter, Inc. Orientation of patient's position sensor using external field
US6830548B2 (en) 2001-09-24 2004-12-14 Ela Medical S.A. Active medical device able to diagnose a patient respiratory profile
US6795732B2 (en) 2001-10-30 2004-09-21 Medtronic, Inc. Implantable medical device employing sonomicrometer output signals for detection and measurement of cardiac mechanical function
US20050027323A1 (en) 2001-10-30 2005-02-03 Medtronic, Inc. Implantable medical device for monitoring cardiac blood pressure and chamber dimension
US20030093002A1 (en) 2001-11-13 2003-05-15 Kuo Terry B.J. Function indicator for autonomic nervous system based on phonocardiogram
US6810284B1 (en) 2001-11-21 2004-10-26 Pacesetter, Inc. Implantable cardiac stimulation system and method for monitoring diastolic function
US20030105497A1 (en) 2001-12-03 2003-06-05 Cardiac Pacemakers, Inc. Implantable cardiac disease management device with trigger-stored polysomnogram and phonocardiogram
US6810287B2 (en) 2001-12-03 2004-10-26 Cardiac Pacemakers, Inc. Implantable cardiac disease management device with trigger-stored polysomnogram and phonocardiogram
US6719701B2 (en) 2002-01-28 2004-04-13 Pacesetter, Inc. Implantable syncope monitor and method of using the same
US20030176896A1 (en) 2002-03-13 2003-09-18 Lincoln William C. Cardiac rhythm management system and method using time between mitral valve closure and aortic ejection
US20030229289A1 (en) 2002-03-18 2003-12-11 Mohler Sailor Hampton Method and system for generating a likelihood of cardiovascular disease, analyzing cardiovascular sound signals remotely from the location of cardiovascular sound signal acquisition, and determining time and phase information from cardiovascular sound signals
US20030216620A1 (en) 2002-05-15 2003-11-20 Mudit Jain Cardiac rhythm management systems and methods using acoustic contractility indicator
US20030233132A1 (en) 2002-06-14 2003-12-18 Pastore Joseph M. Method and apparatus for detecting oscillations in cardiac rhythm
US20040039420A1 (en) 2002-08-26 2004-02-26 Medtronic Physio-Control Manufacturing Corp. Apparatus, software, and methods for cardiac pulse detection using accelerometer data
US20040073093A1 (en) 2002-10-11 2004-04-15 Cardiac Pacemakers, Inc. Methods and devices for detection of context when addressing a medical condition of a patient
US20040111040A1 (en) 2002-12-04 2004-06-10 Quan Ni Detection of disordered breathing
US20040127792A1 (en) 2002-12-30 2004-07-01 Siejko Krzysztof Z. Method and apparatus for monitoring of diastolic hemodynamics
US20040167417A1 (en) 2003-02-26 2004-08-26 Schulhauser Randal C. Apparatus and method for chronically monitoring heart sounds for deriving estimated blood pressure
US20040230243A1 (en) 2003-04-11 2004-11-18 Paul Haefner Noise canceling cardiac electrodes
US20040215264A1 (en) 2003-04-23 2004-10-28 Van Bentem Maarten Detecting heart tones to identify heart deterioration
US20040215265A1 (en) 2003-04-23 2004-10-28 Keizer Diederick M. Sensing techniques for implantable medical devices
US20040225332A1 (en) 2003-05-09 2004-11-11 Ursula Gebhardt Use of accelerometer signal to augment ventricular arrhythmia detection
US20040254481A1 (en) 2003-06-13 2004-12-16 Ge Medical Systems Information Technologies, Inc. Methods and systems for monitoring respiration
US20040267148A1 (en) 2003-06-27 2004-12-30 Patricia Arand Method and system for detection of heart sounds
US20050033190A1 (en) 2003-08-06 2005-02-10 Inovise Medical, Inc. Heart-activity monitoring with multi-axial audio detection
US20050060001A1 (en) 2003-09-15 2005-03-17 Ruchika Singhal Automatic therapy adjustments
US20050148897A1 (en) 2003-12-24 2005-07-07 Cho Yong K. Implantable medical device with sleep disordered breathing monitoring
US20050148896A1 (en) 2003-12-24 2005-07-07 Siejko Krzysztof Z. Method and apparatus for third heart sound detection
US20050149136A1 (en) 2003-12-24 2005-07-07 Siejko Krzysztof Z. Third heart sound activity index for heart failure monitoring
US20060020295A1 (en) 2004-07-23 2006-01-26 Cardiac Pacemakers, Inc. Method and apparatus for monitoring heart failure patients with cardiopulmonary comorbidities
US20060025699A1 (en) 2004-07-28 2006-02-02 Cardiac Pacemakers, Inc. Determining a patient's posture from mechanical vibrations of the heart
US7559901B2 (en) 2004-07-28 2009-07-14 Cardiac Pacemakers, Inc. Determining a patient's posture from mechanical vibrations of the heart
US20060041280A1 (en) 2004-08-19 2006-02-23 Cardiac Pacemakers, Inc. Thoracic impedance detection with blood resistivity compensation
US7403813B1 (en) 2004-11-24 2008-07-22 Pacesetter, Inc. Systems and methods for detection of VT and VF from remote sensing electrodes
US20060161070A1 (en) 2005-01-18 2006-07-20 Cardiac Pacemakers, Inc. Method for correction of posture dependence on heart sounds
WO2006078757A1 (en) 2005-01-18 2006-07-27 Cardiac Pacemakers, Inc. Device measuring heart sounds and posture
US7662104B2 (en) 2005-01-18 2010-02-16 Cardiac Pacemakers, Inc. Method for correction of posture dependence on heart sounds
WO2006127594A3 (en) 2005-05-24 2007-03-22 Cardiac Pacemakers Inc Systems and methods for multi-axis cardiac vibration measurements
US7424321B2 (en) 2005-05-24 2008-09-09 Cardiac Pacemakers, Inc. Systems and methods for multi-axis cardiac vibration measurements
WO2006127594A2 (en) 2005-05-24 2006-11-30 Cardiac Pacemakers, Inc. Systems and methods for multi-axis cardiac vibration measurements
US20060270939A1 (en) 2005-05-24 2006-11-30 Cardiac Pacemakers, Inc. Systems and methods for multi-axis cardiac vibration measurements

Non-Patent Citations (23)

* Cited by examiner, † Cited by third party
Title
"International Search Report and Written Opinion for Application No. PCT/US2006/001801, date mailed Jun. 16, 2006", 12 Pages.
"U.S. Appl. No. 10/900,570, Non-Final Office Action mailed Jan. 10, 2008", 4 pgs.
"U.S. Appl. No. 10/900,570, Non-Final Office Action mailed Jul. 25, 2008", 5 pgs.
"U.S. Appl. No. 10/900,570, Notice of Allowance mailed Mar. 6, 2009", 6 pgs.
"U.S. Appl. No. 10/900,570, Response filed Apr. 10, 2008 to Non-Final Office Action mailed Jan. 10, 2008", 7 pgs.
"U.S. Appl. No. 10/900,570, Response filed Nov. 25, 2008 to Non Final Office Action mailed Jul. 25, 2008", 9 pgs.
"U.S. Appl. No. 10/900,570, Response filed Oct. 22, 2007 to Restriction Requirement mailed Sep. 27, 2007", 7 pgs.
"U.S. Appl. No. 10/900,570, Restriction Requirement mailed Sep. 27, 2007", 6 pgs.
"U.S. Appl. No. 11/037,275, Examiner Interview Summary mailed Apr. 20, 2009", 2 pgs.
"U.S. Appl. No. 11/037,275, Examiner Interview Summary mailed Sep. 5, 2008", 2 pgs.
"U.S. Appl. No. 11/037,275, Final Office Action mailed Jun. 17, 2008", 12 pgs.
"U.S. Appl. No. 11/037,275, Final Office Action mailed Jun. 17, 2009", 11 pgs.
"U.S. Appl. No. 11/037,275, Non-Final Office Action mailed Dec. 12, 2007", 17 pgs.
"U.S. Appl. No. 11/037,275, Non-Final Office Action mailed Jan. 15, 2009", 9 pgs.
"U.S. Appl. No. 11/037,275, Notice of Allowance mailed Sep. 23, 2009", 6 pgs.
"U.S. Appl. No. 11/037,275, Response filed Apr. 15, 2009 to Non Final Office Action mailed Jan. 15, 2009", 12 pgs.
"U.S. Appl. No. 11/037,275, Response filed Aug. 13, 2009 to Final Office Action mailed Jun. 17, 2009", 14 pgs.
"U.S. Appl. No. 11/037,275, Response filed Mar. 3, 2008 to Non Final Office Action mailed Dec. 12, 2007", 16 pgs.
"U.S. Appl. No. 11/037,278, Response filed Sep. 17, 2008 to Final Office Action mailed Jun. 17, 2008", 12 pgs.
"U.S. Appl. No. 11/135,985, Non-Final Office Action Mailed Sep. 25, 2007", 11 Pages.
"U.S. Appl. No. 11/135,985, Notice of Allowance mailed Apr. 25, 2008", 4 pgs.
Pinchak, Alfred C, et al., "Multiaxial Accelerometers", Encyclopedia of Medical Devices and Instrumentation, vol. 1, Department of Electrical and Computer Engineering, (1988), 11 Pages.
Stein, Emanuel, et al., "Rapid Interpretation of Heart Sounds and Murmurs", Baltimore : Williams & Wilkins, 4th ed., (1997), 85-105.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8491488B1 (en) 2010-10-01 2013-07-23 Blaufuss Medical Multimedia Laboratories, LLC Method and system for identifying cardiopulmonary findings by using a heart and lung sounds builder
US8734358B1 (en) 2010-10-01 2014-05-27 Blaufuss Medical Multimedia Laboratories, LLC Method and system for identifying cardiopulmonary findings by using a heart and lung sounds builder

Also Published As

Publication number Publication date Type
US7559901B2 (en) 2009-07-14 grant
US20060025699A1 (en) 2006-02-02 application
US20090247889A1 (en) 2009-10-01 application

Similar Documents

Publication Publication Date Title
US7218966B2 (en) Multi-parameter arrhythmia discrimination
US5876353A (en) Impedance monitor for discerning edema through evaluation of respiratory rate
US6512949B1 (en) Implantable medical device for measuring time varying physiologic conditions especially edema and for responding thereto
US7164948B2 (en) Cardiac output measurement using dual oxygen sensors in right and left ventricles
US7366569B2 (en) Non-invasive method and apparatus for cardiac pacemaker pacing parameter optimization and monitoring of cardiac dysfunction
US6595927B2 (en) Method and system for diagnosing and administering therapy of pulmonary congestion
US20070265671A1 (en) Selectable switching of implantable sensors to provide fault toleance for implantable medical devices
US6912420B2 (en) Cardiac rhythm management system for hypotension
US20090270747A1 (en) Template Matching Method for Monitoring of ECG Morphology Changes
US6931272B2 (en) Method and apparatus to monitor pulmonary edema
US20060041280A1 (en) Thoracic impedance detection with blood resistivity compensation
US7127290B2 (en) Cardiac rhythm management systems and methods predicting congestive heart failure status
US7340296B2 (en) Detection of pleural effusion using transthoracic impedance
US20070239053A1 (en) Method and apparatus for verifying a determined cardiac event in a medical device based on detected variation in hemodynamic status
US7774055B1 (en) Left atrial pressure-based criteria for monitoring intrathoracic impedance
US7206637B2 (en) Cardiac pacing using sensed coronary vein blood temperature and left ventricular flow rate
US20070142732A1 (en) Detection of heart failure decompensation based on cumulative changes in sensor signals
US6823213B1 (en) Implantable medical device and method using integrated T-wave alternans analyzer
US7269460B2 (en) Method and apparatus for evaluating and optimizing ventricular synchronization
US20100030293A1 (en) Using multiple diagnostic parameters for predicting heart failure events
US7209786B2 (en) Method and apparatus for optimization of cardiac resynchronization therapy using heart sounds
US7424321B2 (en) Systems and methods for multi-axis cardiac vibration measurements
US20060271121A1 (en) Closed loop impedance-based cardiac resynchronization therapy systems, devices, and methods
US20080071183A1 (en) Method and apparatus for identifying patients with wide QRS complexes
US20070038253A1 (en) Dual sensing for brady-tachy pacemaker/ICD

Legal Events

Date Code Title Description
FPAY Fee payment

Year of fee payment: 4