US7822463B2 - Method for delivering a device to a target location - Google Patents
Method for delivering a device to a target location Download PDFInfo
- Publication number
- US7822463B2 US7822463B2 US11/166,141 US16614105A US7822463B2 US 7822463 B2 US7822463 B2 US 7822463B2 US 16614105 A US16614105 A US 16614105A US 7822463 B2 US7822463 B2 US 7822463B2
- Authority
- US
- United States
- Prior art keywords
- gastrointestinal tract
- pass
- images
- location
- imaging
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related, expires
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/041—Capsule endoscopes for imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00147—Holding or positioning arrangements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0031—Implanted circuitry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; determining position of probes within or on the body of the patient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; determining position of probes within or on the body of the patient
- A61B5/065—Determining position of the probe employing exclusively positioning means located on or in the probe, e.g. using position sensors arranged on the probe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/07—Endoradiosondes
- A61B5/073—Intestinal transmitters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00002—Operational features of endoscopes
- A61B1/00011—Operational features of endoscopes characterised by signal transmission
- A61B1/00016—Operational features of endoscopes characterised by signal transmission using wireless means
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S128/00—Surgery
- Y10S128/92—Computer assisted medical diagnostics
- Y10S128/922—Computer assisted medical diagnostics including image analysis
Definitions
- the present invention relates to a method for identifying a target location in the gastrointestinal tract and for direct delivery of a device to the identified location
- the stomach In the gastrointestinal tract, the stomach is connected, through the small intestine, a long tube that folds many times to fit inside the abdomen, to the large intestine.
- pathologies of the gastrointestinal tract such as lesions causing chronic gastrointestinal tract blood loss, which occurs in about 2% of US adults, malignancies, most of which give a poor prognosis, and bowel obstructions; simple, closed-loop, strangulated and incarcerated.
- Some of these pathologies, such as small intestinal tumors are difficult to diagnose. Diagnostic methods of the small intestine are usually symptom related or invasive, such as barium enemas or surgery. New methods of diagnosis can lead to an earlier diagnosis and improved prognosis.
- FIG. 1 is a block diagram illustration of a prior art in vivo video camera system for imaging the gastrointestinal tract
- the in vivo video camera system typically comprises a swallowable capsule 10 for viewing inside the digestive system and for transmitting video data, a reception system 12 typically located outside a patient and a data processor 14 for processing the video data.
- the data processor 14 typically operates two monitors, a position monitor 16 on which the current location of the capsule 10 within the digestive system is displayed and an image monitor 18 on which the image currently viewed by the capsule 10 is displayed.
- the reception system 12 can either be portable, in which case, the data it receives is temporarily stored in a storage unit 19 , prior to its processing in data processor 14 , or it can be stationary and close to the data processor 14 .
- FIGS. 2 and 3 are a schematic illustration of calculations performed by a prior art data processor for processing the video data obtained by the above in vivo video camera system.
- FIG. 2 is a front view illustration of the patient 22 with an antenna array 30 wrapped around him. On it, four antennas 34 a - 34 d are noted. Antennas 34 a and 34 b are located in a column at one side of the patient 22 and antennas 34 c and 34 d are located in a column at the other side of the patient 22 .
- antennas 34 a and 34 b define curve 30 a and antennas 34 c and 34 d define curve 30 b.
- curves 30 a and 30 b are typically determined In a calibration step for a predefined number of constant values.
- antennas 34 a - 34 d depends on and is determined from the width L 1 of the patient 22 , which value is typically provided to data processor 14 (of FIG. 1 ) Alternatively, there can be a plurality of antenna arrays 30 , one for each of a pre-defined number of widths L 1 . The antennas 34 a - 34 d are then constant for each antenna array 30 .
- the location of the capsule 10 is typically denoted by a two-dimensional vector P, having a length P and an angle ⁇ , from the center point O of an X-Y coordinate system.
- the cross-sectional location (within an X-Z plane) of the capsule 10 can also be determined using a similar calculation to that illustrated in FIG. 2 .
- a cross-section of the patient 22 is illustrated in FIG. 3 .
- four antennas 34 e - 34 h which are opposite in a cross-sectional manner, are utilized.
- antennas 34 e and 34 h define curve 30 c and antennas 34 f and 34 g define curve 30 d.
- the location of the capsule 10 thus generated is typically denoted by a two-dimensional vector Q having a length Q and an angle ⁇ , from the center point O).
- the two vectors P and Q are combined to determine the three-dimensional location of the capsule 10 .
- the location can be displayed two- or three-dimensionally on position monitor 16 (of FIG. 1 ), typically, though not necessarily, as an overlay to a drawing of the digestive tract.
- Controllable apparatuses for delivery of medicaments are described in U.S. Pat. Nos. 5,558,640 and 4,239,040 While using these apparatuses or capsules the delivery of medicament may be obstructed, such as by folds in the intestine.
- U.S. Pat. No. 5,279,607 describes a method of obtaining directional data from the passage of an ingestible radio signal transmitting capsule. This data is subsequently compared to directional data from a capsule carrying medicament passing through the alimentary canal, for remotely triggering the release of medicament at a calculated geometric location along the gastrointestinal tract.
- a location selected in this method cannot be aligned with sites of interest, such as pathologies, since no diagnostic information, such as information relating to the pathology, can be obtained in this method.
- the geometric location of a site is not the same in a first and second pass, so that this one parameter is only partially sufficient for selection of a site.
- the method combines identification of a target in the gastrointestinal tract and delivery of a utility device to the identified target location.
- the method of the present invention comprises the steps of:
- sensing and utility device delivering the sensing and utility device to a target location identified on the map, using the sensing and utility device in a second pass or, optionally, a plurality of passes, through the gastrointestinal tract.
- the sensing and utility device used in the second pass may be the same or different than the device used in the first pass.
- sensing and utility device refers to a device which is swallowable or placeable (such as described in IL patent application number 122716, assigned to the common assignees of the present invention and which is hereby incorporated by reference), and is capable of sensing selected parameters of the gastrointestinal tract.
- the device also comprises means for performing a job in the gastrointestinal tract. It is controllable and is capable of being monitored and of generating a map of the gastrointestinal tract.
- the sensing and utility device may comprise, for example, any one or any combination of a video camera, which generates an image of the gastrointestinal tract, or sensing means, such as temperature, pressure or pH sensors or means for sensing the presence of blood, microorganisms, parasites or pathological indications or any objects alien to the gastrointestinal tract.
- sensing means such as temperature, pressure or pH sensors or means for sensing the presence of blood, microorganisms, parasites or pathological indications or any objects alien to the gastrointestinal tract.
- Means for performing a job may be any means suitable for researching, diagnosing or treating pathologies in the gastrointestinal tract, for example, fluid or cell sampling means, marker releasing means or medicament releasing means.
- a map of the gastrointestinal tract may be generated by inserting the sensing and utility device into the gastrointestinal tract, monitoring the progress of the device through the gastrointestinal tract and optionally displaying the locations, two or three dimensionally, on a position monitor.
- Monitoring the device is by periodically or repeatedly locating the device, preferably, as described in U.S. Pat. No. 5,604,531 assigned to the common assignees of the present invention.
- U.S. Pat. No. 5,604,531 is hereby incorporated by reference.
- Delivering the sensing and utility device to a target location identified on the map comprises the steps of inserting the sensing and utility device into the gastrointestinal tract, in a second pass, receiving data from the device, either visual, from a video camera, or from the output of other sensing means, performing signal analysis of the data generated in the first pass and the data received from said sensing and utility device in the second pass; and controlling, such as by IR or telephony, the sensing and utility device according to the signal analysis.
- the method of the present invention may be used for research, diagnostic or therapeutic purposes in the gastrointestinal tract.
- FIG. 1 is a block diagram illustration of a prior art in vivo video camera system for imaging the gastrointestinal tract;
- FIGS. 2 and 3 are schematic illustrations of calculations performed by a prior art data processor for processing the video data obtained by the in vivo video camera system for imaging the gastrointestinal tract, utilizing an antenna array, wherein FIG. 3 is a top view illustration of the antenna array and FIG. 2 is a cross-sectional illustration of the antenna array.
- FIG. 4 is an illustration of a sensing and utility device according to a preferred embodiment of the invention.
- FIG. 5A is an illustration of a storage compartment, according to a preferred embodiment of the invention, in a recoiled position of the bi stable spring;
- FIG. 5B is an illustration of a storage compartment, according to a preferred embodiment of the invention, in an extended position of the bi stable spring;
- FIG. 5C is an enlargement of the storgae compartment tip, according to a preferred embodiment of the invention.
- FIG. 6 is an illustration of a sensing and utility device operable according to a preferred embodiment of the invention.
- FIG. 7 is an illustration of a generated and displayed map in the method according to a preferred embodiment of the invention.
- the method of the present invention combines diagnostic and therapeutic processes. For example, the method combines identifying and localizing a pathology in the gastrointestinal tract with administrating treatment to the location of the pathology, by non invasive means.
- This combination is provided by employing a sensing and utility device which is inserted into the gastrointestinal tract, either by swallowing it or by placing it in the gastrointestinal tract.
- the above mentioned IL patent application 122716 describes a device for the placement of an autonomous capsule in the gastrointestinal tract, which bypasses the need for swallowing the capsule by the patent.
- the sensing and utility capsule shaped device typically comprises a light source 42 , a viewing window 44 , through which the light illuminates the inner portions of the digestive system, a camera system 46 , such as a charge-coupled device (CCD) or CMOS camera, which detects the images, an optical system 48 (typically comprising a mirror 47 and a focusing lens 47 ′) which focuses the images onto the CCD or CMOS camera system 46 , a transmitter 41 , which transmits the video signal of the CCD or CMOS camera system 46 , a power source 43 , such as a battery, which provides power to the entirety of electrical elements of the capsule and a storage compartment 45 , for the controllable discharge of medicaments or markers or for the controllable collection of fluid or cell samples from the environment, such as in a biopsy procedure.
- a power source 43 such as a battery
- the sensing and utility device can additionally include any known sensor element 49 such as temperature, pressure or pH sensors or means for sensing the presence of blood, microorganisms, parasites or pathological indications or any objects alien to the gastrointestinal tract.
- any known sensor element 49 such as temperature, pressure or pH sensors or means for sensing the presence of blood, microorganisms, parasites or pathological indications or any objects alien to the gastrointestinal tract.
- FIGS. 5A , 5 B and 5 C are illustrations of a storage compartment, according to a preferred embodiment of the invention
- Storage compartment 55 is located preferably at an end of the sensing and utility device, generally referenced 50 .
- the storage compartment is defined by an inflexible barrier 59 and the device shell.
- the storage compartment contains a pouch 56 made of flexible material which is encased by the device outer shell 52 and by a firm diaphragm 54 having an elasticity which will allow it to accommodate to a capsule shape.
- Diaphragm 54 is horizontally movable between the inflexible barrier 59 and the device tip.
- the pouch 56 is designed to retain substances such as releasable medicaments or markers or such as fluid or cell samples from the gastrointestinal tract environment.
- the pouch 56 bulk is determined by a bi stable spring 53 , preferably made of a memory shape metal such as TiNi.
- the spring 53 is attached, at one end to the solid barrier 59 , and at its other end, to the diaphragm 54 .
- the spring 53 may be made to extend (as shown in FIG. 5B ) or recoil (as shown in FIG. 5A ) by providing different temperatures, as known in the art (the means for providing different temperatures, such as conducting wires, are not shown).
- the pouch 56 bulk may be reversably increased or decreased.
- FIG. 5A illustrates a piercing pin 57 which is attached to the pouch wall and which protrudes into the pouch 56 inner space, in the direction of the opposing pouch wall 56 ′.
- spring 53 is made to extend, causing diaphragm 54 to move towards the device end, thrusting the piercing pin 57 into the opposing pouch wall 56 ′, rupturing it.
- a substance contained in the pouch 56 will be released into a space 51 provided between the opposing pouch wall 56 ′ and the outer shell permeable area 58 . The released substance may then pass through the openings in the permeable area 58 into the gastrointestinal tract.
- FIG. 5B illustrates a pouch 56 meant for collecting a sample from the gastrointestinal tract.
- the bi stable spring 53 is lodged in opposing pouch wall 56 ′.
- the spring 53 is made to recoil, pulling with it diaphragm 54 and piercing pin 57 , such that piercing pin 57 is dislodged from the opposing pouch wall 56 ′, rupturing it and leaving an opening in the pouch, through which substances from the environment are drawn into the pouch 56 .
- the opening in the pouch is sealed after the sample is drawn in from the environment, ensuring a fixed volume and sterility of the collected sample.
- Pin 57 may be a hollow cylinder through which substances may pass to or from the gastrointestinal tract.
- FIG. 5C is an enlargement of the device end, through which substances are drawn into, or released from, the pouch.
- space 51 is provided, ensuring that the pin 57 , either before being dislodged from wall 56 ′ for collecting substances, or when piercing wall 56 ′ for release of substances, doesn't protrude further than the device shell 52 and injure the patient's insides.
- FIG. 6 is an illustration of a sensing and utility device operable according to a preferred embodiment of the invention
- FIG. 7 is an illustration of a map of the gastrointestinal tract generated in the method, according to a preferred embodiment of the invention.
- Capsule 60 moves through the gastrointestinal tract 62 in a first pass to generate, by visual means, a map of the gastrointestinal tract and to identify, by visual means or other sensor means, a location of interest in the gastrointestinal tract. In its second pass, capsule 60 moves through the gastrointestinal tract and is controlled to perform a job at the identified location.
- Recognition of the location, identified in the first pass, is done, in analyzing unit 65 , by analysis of the map generated in the first pass and bringing into conformity parameters, visual or others, obtained in the first pass and in the second pass. This may be acheived by any of the well known techniques of image matching by correlation, as done in image analysis, or any other suitable signal analysis techniques.
- the capsule 60 As the capsule 60 moves through the digestive system (gastrointestinal tract) 62 , in its first pass, it views the walls of the digestive system in the method described in FIGS. 2 and 3 and in U.S. Pat. No. 5,604,531, and transmits the resultant images to a reception system 64 typically located outside a patient.
- the reception system 64 receives a multiplicity of versions of the images, each version received by a different antenna (described in FIGS. 2 and 3 ) and either stores the received signals in the storage unit 68 or provides the received signals, directly, by IR or telephony, to the data processor 66 .
- the data processor 66 typically operates two monitors, a position monitor 63 , on which the current location of the capsule 60 within the digestive system is recorded, and, optionally, displayed and an image monitor 61 , on which the image currently viewed by the capsule 60 is displayed.
- the reception system 64 can either be portable, in which case, the data it receives is temporarily stored in a storage unit 68 prior to its processing in data processor 66 , or it can be stationary and close to the data processor 66 .
- the capsule 60 location can be displayed two- or three-dimensionally on position monitor 63 , typically, though not necessarily, as an overlay to a drawing of the digestive tract.
- the progress of capsule 60 is monitored by repeated or periodic localization of the capsule, and can be displayed on position monitor 63 .
- a forward filming device can be distinguished from a backwards filming device by the flow direction of the image information relating to the direction of the device motion enables more precise localization of the storage compartment end of the device. Furthermore, analysis of the optical flow enables to calculate the device velocity in the gastrointestinal tract.
- the repeated localizations generate a map of the route taken by the capsule in the gastrointestinal tract 62 .
- the generated map 70 is shown in FIG. 7 .
- images displayed on image monitor 61 are compared with the generated map 70 displayed on position monitor 63 to identify the location of a pathology 72 , though, a location may be identified by analysis of parameters other than visual (such as pH, temp, etc.), which were sensed during the first pass in the gastrointestinal tract.
- capsule 60 Upon identifying the location of a pathology 72 on the gastrointestinal tract map 70 , either visually or by analysis of other sensor means input, capsule 60 is inserted into the gastrointestinal tract for a second pass. As capsule 60 moves through the digestive system 62 , in its second pass, it is monitored as above. When arriving at the location of the pathology 72 , or at any other point on map 70 , determined as the point for advantageously releasing medicament for the treatment of the pathology, the capsule 60 is controlled to release the medicament from the medicament storage compartment of the capsule ( 45 in FIG. 4 ). The release of the medicament may be autonomous, automatically controlled by analyzing unit 65 or remotely controlled by an external operator.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Optics & Photonics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Human Computer Interaction (AREA)
- Computer Networks & Wireless Communication (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Endoscopes (AREA)
Abstract
An autonomous device that may include for example a camera, a transmitter for transmitting a signal from the camera and a storage compartment for retaining a substance in the device. A method of delivering a medicament to a patient including imaging a gastro intestinal tract with an autonomous device, identifying a target location in such tract, and releasing a medicament from the device at the target location.
Description
This application is a Continuation Application of U.S. patent application Ser. No 09/807,892, filed on Jun. 6, 2001, now U.S. Pat. No. 6,950,690,which is a national phase application of International Application PCT/LL99/00554 filed Oct. 21, 1999, which in turn takes benefit from Israeli Patent Application 126727 filed on Oct. 22, 1998, all of which are incorporated by reference herein in their entirety.
The present invention relates to a method for identifying a target location in the gastrointestinal tract and for direct delivery of a device to the identified location
In the gastrointestinal tract, the stomach is connected, through the small intestine, a long tube that folds many times to fit inside the abdomen, to the large intestine. There are numerous pathologies of the gastrointestinal tract, such as lesions causing chronic gastrointestinal tract blood loss, which occurs in about 2% of US adults, malignancies, most of which give a poor prognosis, and bowel obstructions; simple, closed-loop, strangulated and incarcerated. Some of these pathologies, such as small intestinal tumors, are difficult to diagnose. Diagnostic methods of the small intestine are usually symptom related or invasive, such as barium enemas or surgery. New methods of diagnosis can lead to an earlier diagnosis and improved prognosis.
U.S. Pat. No. 5,604,531 describes an in viva video camera system which can image the gastrointestinal tract. Reference is now made to FIG. 1 , which is a block diagram illustration of a prior art in vivo video camera system for imaging the gastrointestinal tract The in vivo video camera system typically comprises a swallowable capsule 10 for viewing inside the digestive system and for transmitting video data, a reception system 12 typically located outside a patient and a data processor 14 for processing the video data. The data processor 14 typically operates two monitors, a position monitor 16 on which the current location of the capsule 10 within the digestive system is displayed and an image monitor 18 on which the image currently viewed by the capsule 10 is displayed.
The reception system 12 can either be portable, in which case, the data it receives is temporarily stored in a storage unit 19, prior to its processing in data processor 14, or it can be stationary and close to the data processor 14.
Reference is now made to FIGS. 2 and 3 which are a schematic illustration of calculations performed by a prior art data processor for processing the video data obtained by the above in vivo video camera system. FIG. 2 is a front view illustration of the patient 22 with an antenna array 30 wrapped around him. On it, four antennas 34 a-34 d are noted. Antennas 34 a and 34 b are located in a column at one side of the patient 22 and antennas 34 c and 34 d are located in a column at the other side of the patient 22.
Since the strength of a signal received by any given antenna depends on its distance from and angle to the transmitter, the ratio of the signal strengths between any two antennas, which have the transmitter between them, is constant along a curve which intersects the location of the transmitter. Thus, antennas 34 a and 34 b define curve 30 a and antennas 34 c and 34 d define curve 30 b.
The intersection of curves 30 a and 30 b is the location of the transmitter which is the location of the capsule 10. The curves 30 a and 30 b are typically determined In a calibration step for a predefined number of constant values.
The designation of antennas 34 a-34 d depends on and is determined from the width L1 of the patient 22, which value is typically provided to data processor 14 (of FIG. 1 ) Alternatively, there can be a plurality of antenna arrays 30, one for each of a pre-defined number of widths L1. The antennas 34 a-34 d are then constant for each antenna array 30.
The location of the capsule 10, thus generated, is typically denoted by a two-dimensional vector P, having a length P and an angle □, from the center point O of an X-Y coordinate system.
The cross-sectional location (within an X-Z plane) of the capsule 10 can also be determined using a similar calculation to that illustrated in FIG. 2 . A cross-section of the patient 22 is illustrated in FIG. 3 . For this determination, four antennas 34 e-34 h, which are opposite in a cross-sectional manner, are utilized.
Once again, the ratio of the signal strengths between two antennas, which have the transmitter between them, is constant along a curve which intersects the location of the transmitter. Thus, antennas 34 e and 34 h define curve 30 c and antennas 34 f and 34 g define curve 30 d.
The location of the capsule 10 thus generated is typically denoted by a two-dimensional vector Q having a length Q and an angle □, from the center point O).
The two vectors P and Q are combined to determine the three-dimensional location of the capsule 10. The location can be displayed two- or three-dimensionally on position monitor 16 (of FIG. 1 ), typically, though not necessarily, as an overlay to a drawing of the digestive tract.
There exist methods for the delivery of medicament to a selected site in the gastrointestinal tract, such as the use of time delivery capsules made of material that dissolves in a particular environment and/or within a particular time period, within the gastrointestinal tract. In these methods, the delivery of medicament is dependent on the predictability of the particular environment to which the capsule is directed.
Controllable apparatuses for delivery of medicaments are described in U.S. Pat. Nos. 5,558,640 and 4,239,040 While using these apparatuses or capsules the delivery of medicament may be obstructed, such as by folds in the intestine.
These methods can not be relied upon for localized release of a medicament.
U.S. Pat. No. 5,279,607 describes a method of obtaining directional data from the passage of an ingestible radio signal transmitting capsule. This data is subsequently compared to directional data from a capsule carrying medicament passing through the alimentary canal, for remotely triggering the release of medicament at a calculated geometric location along the gastrointestinal tract. A location selected in this method, cannot be aligned with sites of interest, such as pathologies, since no diagnostic information, such as information relating to the pathology, can be obtained in this method. Furthermore, due to the constant peristaltic movement of the alimentary canal, the geometric location of a site is not the same in a first and second pass, so that this one parameter is only partially sufficient for selection of a site.
There exist no medicament delivering systems which combine diagnostic and therapeutic processes.
It is an object of the present invention to provide a method for delivering a utility device to a target location in the gastrointestinal tract. The method combines identification of a target in the gastrointestinal tract and delivery of a utility device to the identified target location. The method of the present invention comprises the steps of:
a) generating a map of the gastrointestinal tract, employing a sensing and utility device for a first pass, or, optionally, a plurality of passes through the gastrointestinal tract; and
b) delivering the sensing and utility device to a target location identified on the map, using the sensing and utility device in a second pass or, optionally, a plurality of passes, through the gastrointestinal tract. The sensing and utility device used in the second pass, may be the same or different than the device used in the first pass.
The term “sensing and utility device”, in the present invention, refers to a device which is swallowable or placeable (such as described in IL patent application number 122716, assigned to the common assignees of the present invention and which is hereby incorporated by reference), and is capable of sensing selected parameters of the gastrointestinal tract. The device also comprises means for performing a job in the gastrointestinal tract. It is controllable and is capable of being monitored and of generating a map of the gastrointestinal tract.
The sensing and utility device may comprise, for example, any one or any combination of a video camera, which generates an image of the gastrointestinal tract, or sensing means, such as temperature, pressure or pH sensors or means for sensing the presence of blood, microorganisms, parasites or pathological indications or any objects alien to the gastrointestinal tract.
Means for performing a job may be any means suitable for researching, diagnosing or treating pathologies in the gastrointestinal tract, for example, fluid or cell sampling means, marker releasing means or medicament releasing means.
A map of the gastrointestinal tract may be generated by inserting the sensing and utility device into the gastrointestinal tract, monitoring the progress of the device through the gastrointestinal tract and optionally displaying the locations, two or three dimensionally, on a position monitor.
Monitoring the device is by periodically or repeatedly locating the device, preferably, as described in U.S. Pat. No. 5,604,531 assigned to the common assignees of the present invention. U.S. Pat. No. 5,604,531 is hereby incorporated by reference.
Delivering the sensing and utility device to a target location identified on the map comprises the steps of inserting the sensing and utility device into the gastrointestinal tract, in a second pass, receiving data from the device, either visual, from a video camera, or from the output of other sensing means, performing signal analysis of the data generated in the first pass and the data received from said sensing and utility device in the second pass; and controlling, such as by IR or telephony, the sensing and utility device according to the signal analysis.
The method of the present invention may be used for research, diagnostic or therapeutic purposes in the gastrointestinal tract.
The present invention will be understood and appreciated more fully from the following detailed description taken in conjunction with the drawings in which:
The method of the present invention combines diagnostic and therapeutic processes. For example, the method combines identifying and localizing a pathology in the gastrointestinal tract with administrating treatment to the location of the pathology, by non invasive means. This combination is provided by employing a sensing and utility device which is inserted into the gastrointestinal tract, either by swallowing it or by placing it in the gastrointestinal tract. The above mentioned IL patent application 122716 describes a device for the placement of an autonomous capsule in the gastrointestinal tract, which bypasses the need for swallowing the capsule by the patent.
Reference is now made to FIG. 4 which is an illustration of a sensing and utility device according to a preferred embodiment of the invention. The sensing and utility capsule shaped device, generally referenced 40, typically comprises a light source 42, a viewing window 44, through which the light illuminates the inner portions of the digestive system, a camera system 46, such as a charge-coupled device (CCD) or CMOS camera, which detects the images, an optical system 48 (typically comprising a mirror 47 and a focusing lens 47′) which focuses the images onto the CCD or CMOS camera system 46, a transmitter 41, which transmits the video signal of the CCD or CMOS camera system 46, a power source 43, such as a battery, which provides power to the entirety of electrical elements of the capsule and a storage compartment 45, for the controllable discharge of medicaments or markers or for the controllable collection of fluid or cell samples from the environment, such as in a biopsy procedure.
The sensing and utility device can additionally include any known sensor element 49 such as temperature, pressure or pH sensors or means for sensing the presence of blood, microorganisms, parasites or pathological indications or any objects alien to the gastrointestinal tract.
Reference is now made to FIGS. 5A , 5B and 5C which are illustrations of a storage compartment, according to a preferred embodiment of the invention
Reference is now made to FIGS. 6 and 7 . FIG. 6 is an illustration of a sensing and utility device operable according to a preferred embodiment of the invention, and FIG. 7 is an illustration of a map of the gastrointestinal tract generated in the method, according to a preferred embodiment of the invention.
Recognition of the location, identified in the first pass, is done, in analyzing unit 65, by analysis of the map generated in the first pass and bringing into conformity parameters, visual or others, obtained in the first pass and in the second pass. This may be acheived by any of the well known techniques of image matching by correlation, as done in image analysis, or any other suitable signal analysis techniques.
As the capsule 60 moves through the digestive system (gastrointestinal tract) 62, in its first pass, it views the walls of the digestive system in the method described in FIGS. 2 and 3 and in U.S. Pat. No. 5,604,531, and transmits the resultant images to a reception system 64 typically located outside a patient. The reception system 64 receives a multiplicity of versions of the images, each version received by a different antenna (described in FIGS. 2 and 3 ) and either stores the received signals in the storage unit 68 or provides the received signals, directly, by IR or telephony, to the data processor 66. The data processor 66 typically operates two monitors, a position monitor 63, on which the current location of the capsule 60 within the digestive system is recorded, and, optionally, displayed and an image monitor 61, on which the image currently viewed by the capsule 60 is displayed.
The reception system 64 can either be portable, in which case, the data it receives is temporarily stored in a storage unit 68 prior to its processing in data processor 66, or it can be stationary and close to the data processor 66.
The capsule 60 location can be displayed two- or three-dimensionally on position monitor 63, typically, though not necessarily, as an overlay to a drawing of the digestive tract. The progress of capsule 60 is monitored by repeated or periodic localization of the capsule, and can be displayed on position monitor 63.
A forward filming device can be distinguished from a backwards filming device by the flow direction of the image information relating to the direction of the device motion enables more precise localization of the storage compartment end of the device. Furthermore, analysis of the optical flow enables to calculate the device velocity in the gastrointestinal tract.
The repeated localizations generate a map of the route taken by the capsule in the gastrointestinal tract 62. The generated map 70 is shown in FIG. 7 . For maximum accuracy, images displayed on image monitor 61 are compared with the generated map 70 displayed on position monitor 63 to identify the location of a pathology 72, though, a location may be identified by analysis of parameters other than visual (such as pH, temp, etc.), which were sensed during the first pass in the gastrointestinal tract.
Upon identifying the location of a pathology 72 on the gastrointestinal tract map 70, either visually or by analysis of other sensor means input, capsule 60 is inserted into the gastrointestinal tract for a second pass. As capsule 60 moves through the digestive system 62, in its second pass, it is monitored as above. When arriving at the location of the pathology 72, or at any other point on map 70, determined as the point for advantageously releasing medicament for the treatment of the pathology, the capsule 60 is controlled to release the medicament from the medicament storage compartment of the capsule (45 in FIG. 4 ). The release of the medicament may be autonomous, automatically controlled by analyzing unit 65 or remotely controlled by an external operator.
It will be appreciated by persons skilled in the art that the present invention is not limited by what has been particularly shown and described herein above. Rather the scope of the invention is defined by the claims which follow:
Claims (13)
1. A method for administering a medicament to a patient, the method comprising:
imaging a first set of images from an area of the gastrointestinal tract with a first autonomous swallowable device in a first pass through the gastrointestinal tract;
accepting identification of an image of a location of interest in the gastrointestinal tract, with an analyzing unit;
imaging a second set of images from an area of the gastrointestinal tract with the first or a second autonomous swallowable device in a second pass through the gastrointestinal tract;
accepting results of image analysis performed with the analyzing unit by comparing images from the first set with images from the second set to identify in the second set an image of the location of interest corresponding to an image of the location of interest in the first set; and
releasing a medicament from said first or second device at said location of interest in the gastrointestinal tract during said second pass through the gastrointestinal tract.
2. The method according to claim 1 , comprising transmitting the images obtained by the swallowable device.
3. The method according to claim 1 , wherein the release of the medicament from said first or second swallowable device during said second pass through the gastrointestinal tract is controlled by the analyzing unit.
4. The method according to claim 1 , wherein the release of the medicament from said first or second swallowable device is controlled automatically by the device.
5. The method according to claim 1 , wherein the release of the medicament from said first or second swallowable device is controlled remotely by an external operator.
6. The method according to claim 1 , wherein said first or second autonomous device further comprises a sensor element selected from a group consisting of a temperature sensor, a pH sensor, a pressure sensor, and a sensor for sensing pathology.
7. The method according to claim 1 , further comprising transmitting said images to an antenna array, said antenna array being outside a patient.
8. The method according to claim 1 , wherein imaging the first set of images is performed by the first autonomous swallowable device in the first pass through the gastrointestinal tract, and wherein imaging the second set of images is performed by the second autonomous swallowable device in the second pass through the gastrointestinal tract.
9. The method according to claim 1 , wherein imaging the first set of images in the first pass through the gastrointestinal tract and imaging the second set of images in the second pass through the gastrointestinal tract are both performed by the first autonomous swallowable device.
10. A method for image analysis of a gastrointestinal tract using at least one autonomous device comprising a camera system, a transmitter and an analyzing unit, said method comprising:
generating a first set of images in a first pass of a first autonomous imaging device through the gastrointestinal tract and a second set of images in a second pass of a second imaging device through the gastrointestinal tract, the second imaging device further having a storage compartment for retaining a substance therein;
transmitting the first set of images in the first pass in the gastrointestinal tract;
transmitting the second set of images in the second pass in the gastrointestinal tract;
analyzing the first set of images and bringing into conformity visual parameters of the set of images obtained in the first pass and visual parameters of the set of images obtained in the second pass, thereby recognizing in the second pass a location of interest in the gastrointestinal tract which has been identified in the first pass; and
releasing the substance from said storage compartment of the second imaging device at said location of interest during the second pass in the gastrointestinal tract.
11. The method according to claim 10 , wherein said first or second autonomous device further comprises a sensor element selected from a group consisting of a temperature sensor, a pH sensor, a pressure sensor, and a sensor for sensing pathology.
12. The method according to claim 10 , wherein the substance retained within said storage compartment is a medicament.
13. The method according to claim 10 , further comprising transmitting said images to an antenna array, said antenna array being outside a patient.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/166,141 US7822463B2 (en) | 1998-10-22 | 2005-06-27 | Method for delivering a device to a target location |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL126727A IL126727A (en) | 1998-10-22 | 1998-10-22 | Method for delivering a device to a target location |
IL126727 | 1998-10-22 | ||
US09/807,892 US6950690B1 (en) | 1998-10-22 | 1999-10-21 | Method for delivering a device to a target location |
PCT/IL1999/000554 WO2000022975A1 (en) | 1998-10-22 | 1999-10-21 | A method for delivering a device to a target location |
US11/166,141 US7822463B2 (en) | 1998-10-22 | 2005-06-27 | Method for delivering a device to a target location |
Related Parent Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09807892 Continuation | 1999-10-21 | ||
PCT/IL1999/000554 Continuation WO2000022975A1 (en) | 1998-10-22 | 1999-10-21 | A method for delivering a device to a target location |
US09/807,892 Continuation US6950690B1 (en) | 1998-10-22 | 1999-10-21 | Method for delivering a device to a target location |
Publications (2)
Publication Number | Publication Date |
---|---|
US20060004285A1 US20060004285A1 (en) | 2006-01-05 |
US7822463B2 true US7822463B2 (en) | 2010-10-26 |
Family
ID=11072059
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/807,892 Expired - Lifetime US6950690B1 (en) | 1998-10-22 | 1999-10-21 | Method for delivering a device to a target location |
US11/166,141 Expired - Fee Related US7822463B2 (en) | 1998-10-22 | 2005-06-27 | Method for delivering a device to a target location |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/807,892 Expired - Lifetime US6950690B1 (en) | 1998-10-22 | 1999-10-21 | Method for delivering a device to a target location |
Country Status (7)
Country | Link |
---|---|
US (2) | US6950690B1 (en) |
EP (1) | EP1123035B1 (en) |
JP (2) | JP4059628B2 (en) |
AU (1) | AU6364599A (en) |
CA (1) | CA2347274C (en) |
IL (1) | IL126727A (en) |
WO (1) | WO2000022975A1 (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8682142B1 (en) | 2010-03-18 | 2014-03-25 | Given Imaging Ltd. | System and method for editing an image stream captured in-vivo |
US9044543B2 (en) | 2012-07-17 | 2015-06-02 | Elwha Llc | Unmanned device utilization methods and systems |
US9061102B2 (en) | 2012-07-17 | 2015-06-23 | Elwha Llc | Unmanned device interaction methods and systems |
US9131842B2 (en) | 2012-08-16 | 2015-09-15 | Rock West Solutions, Inc. | System and methods for locating relative positions of multiple patient antennas |
US10045713B2 (en) | 2012-08-16 | 2018-08-14 | Rock West Medical Devices, Llc | System and methods for triggering a radiofrequency transceiver in the human body |
US10102334B2 (en) | 2010-12-30 | 2018-10-16 | Given Imaging Ltd. | System and method for automatic navigation of a capsule based on image stream captured in-vivo |
US10945635B2 (en) | 2013-10-22 | 2021-03-16 | Rock West Medical Devices, Llc | Nearly isotropic dipole antenna system |
Families Citing this family (184)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL126727A (en) | 1998-10-22 | 2006-12-31 | Given Imaging Ltd | Method for delivering a device to a target location |
US7154527B1 (en) | 1999-02-25 | 2006-12-26 | Visionsense Ltd. | Optical device |
US8248457B2 (en) | 1999-02-25 | 2012-08-21 | Visionsense, Ltd. | Optical device |
US6396873B1 (en) | 1999-02-25 | 2002-05-28 | Envision Advanced Medical Systems | Optical device |
US7116352B2 (en) | 1999-02-25 | 2006-10-03 | Visionsense Ltd. | Capsule |
US7683926B2 (en) | 1999-02-25 | 2010-03-23 | Visionsense Ltd. | Optical device |
US7914442B1 (en) | 1999-03-01 | 2011-03-29 | Gazdzinski Robert F | Endoscopic smart probe and method |
US10973397B2 (en) | 1999-03-01 | 2021-04-13 | West View Research, Llc | Computerized information collection and processing apparatus |
US8068897B1 (en) | 1999-03-01 | 2011-11-29 | Gazdzinski Robert F | Endoscopic smart probe and method |
US8636648B2 (en) | 1999-03-01 | 2014-01-28 | West View Research, Llc | Endoscopic smart probe |
US8229549B2 (en) | 2004-07-09 | 2012-07-24 | Tyco Healthcare Group Lp | Surgical imaging device |
US8065155B1 (en) | 1999-06-10 | 2011-11-22 | Gazdzinski Robert F | Adaptive advertising apparatus and methods |
IL130486A (en) | 1999-06-15 | 2005-08-31 | Given Imaging Ltd | Optical system |
IL132944A (en) | 1999-11-15 | 2009-05-04 | Arkady Glukhovsky | Method for activating an image collecting process |
IL134017A (en) * | 2000-01-13 | 2008-04-13 | Capsule View Inc | Camera for viewing inside intestines |
IL150810A0 (en) | 2000-01-19 | 2003-02-12 | Given Imaging Ltd | A system for detecting substances |
EP1779776A3 (en) | 2000-03-08 | 2007-05-09 | Given Imaging Ltd. | A device and system for in vivo imaging |
US6709387B1 (en) * | 2000-05-15 | 2004-03-23 | Given Imaging Ltd. | System and method for controlling in vivo camera capture and display rate |
IL163684A0 (en) | 2000-05-31 | 2005-12-18 | Given Imaging Ltd | Measurement of electrical characteristics of tissue |
US8909325B2 (en) | 2000-08-21 | 2014-12-09 | Biosensors International Group, Ltd. | Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures |
WO2005119025A2 (en) | 2004-06-01 | 2005-12-15 | Spectrum Dynamics Llc | Radioactive-emission-measurement optimization to specific body structures |
US7553276B2 (en) | 2001-01-16 | 2009-06-30 | Given Imaging Ltd. | Method and device for imaging body lumens |
US7468044B2 (en) | 2001-01-16 | 2008-12-23 | Given Imaging Ltd. | Device, system and method for determining in vivo body lumen conditions |
EP1359845B1 (en) * | 2001-01-22 | 2012-11-14 | Spectrum Dynamics LLC | Ingestible device |
JP3958526B2 (en) * | 2001-02-28 | 2007-08-15 | ペンタックス株式会社 | Observation site display system for electronic endoscope apparatus |
US20020177779A1 (en) * | 2001-03-14 | 2002-11-28 | Doron Adler | Method and system for detecting colorimetric abnormalities in vivo |
IL143259A (en) | 2001-05-20 | 2006-08-01 | Given Imaging Ltd | Method for moving an object through the colon |
EP1397660B1 (en) * | 2001-05-20 | 2013-05-15 | Given Imaging Ltd. | A floatable in vivo sensing device |
IL143260A (en) * | 2001-05-20 | 2006-09-05 | Given Imaging Ltd | Array system and method for locating an in vivo signal source |
IL150167A (en) * | 2001-06-11 | 2010-05-17 | Arkady Glukhovsky | Device for in vivo imaging |
ATE404114T1 (en) | 2001-06-18 | 2008-08-15 | Given Imaging Ltd | SWALLOWABLE IN-VIVO CAPSULE WITH A CIRCUIT BOARD HAVING RIGID AND FLEXIBLE SECTIONS |
US7160258B2 (en) * | 2001-06-26 | 2007-01-09 | Entrack, Inc. | Capsule and method for treating or diagnosing the intestinal tract |
US20030043263A1 (en) * | 2001-07-26 | 2003-03-06 | Arkady Glukhovsky | Diagnostic device using data compression |
US9113846B2 (en) | 2001-07-26 | 2015-08-25 | Given Imaging Ltd. | In-vivo imaging device providing data compression |
US6951536B2 (en) | 2001-07-30 | 2005-10-04 | Olympus Corporation | Capsule-type medical device and medical system |
JP4744026B2 (en) * | 2001-07-30 | 2011-08-10 | オリンパス株式会社 | Capsule endoscope and capsule endoscope system |
AU2002334354A1 (en) * | 2001-09-05 | 2003-03-18 | Given Imaging Ltd. | System and method for three dimensional display of body lumens |
DE10146197B4 (en) * | 2001-09-14 | 2016-04-21 | Karl Storz Gmbh & Co. Kg | Intracorporeal probe for the analysis or diagnosis of, for example, hollow organs and body cavities in the human or animal body |
JP3756797B2 (en) | 2001-10-16 | 2006-03-15 | オリンパス株式会社 | Capsule type medical equipment |
US6866626B2 (en) | 2001-11-09 | 2005-03-15 | Ethicon-Endo Surgery, Inc. | Self-propelled, intraluminal device with working channel and method of use |
IL147221A (en) * | 2001-12-20 | 2010-11-30 | Given Imaging Ltd | Device, system and method for image based size analysis |
CN100518621C (en) | 2002-01-30 | 2009-07-29 | 能量医学介入公司 | Surgical imaging device |
WO2003069913A1 (en) * | 2002-02-12 | 2003-08-21 | Given Imaging Ltd. | System and method for displaying an image stream |
US7474327B2 (en) | 2002-02-12 | 2009-01-06 | Given Imaging Ltd. | System and method for displaying an image stream |
US8022980B2 (en) | 2002-02-12 | 2011-09-20 | Given Imaging Ltd. | System and method for displaying an image stream |
US7485093B2 (en) | 2002-04-25 | 2009-02-03 | Given Imaging Ltd. | Device and method for in-vivo sensing |
US7662094B2 (en) | 2002-05-14 | 2010-02-16 | Given Imaging Ltd. | Optical head assembly with dome, and device for use thereof |
FR2842721B1 (en) * | 2002-07-25 | 2005-06-24 | Assist Publ Hopitaux De Paris | METHOD FOR NON-INVASIVE AND AMBULATORY EXPLORATION OF DIGESTIVE TRACTION AND TRANSIT AND CORRESPONDING SYSTEM |
US7684840B2 (en) | 2002-08-13 | 2010-03-23 | Given Imaging, Ltd. | System and method for in-vivo sampling and analysis |
WO2004028335A2 (en) | 2002-09-30 | 2004-04-08 | Given Imaging Ltd. | In-vivo sensing system |
US7662093B2 (en) | 2002-09-30 | 2010-02-16 | Given Imaging, Ltd. | Reduced size imaging device |
US7351202B2 (en) | 2002-12-05 | 2008-04-01 | Ethicon Endo-Surgery, Inc. | Medical device with track and method of use |
US7226410B2 (en) | 2002-12-05 | 2007-06-05 | Ethicon-Endo Surgery, Inc. | Locally-propelled, intraluminal device with cable loop track and method of use |
WO2004091361A2 (en) * | 2002-12-24 | 2004-10-28 | Entrack, Inc. | Optical capsule and spectroscopic method for treating or diagnosing the intestinal tract |
JP2006512130A (en) | 2002-12-26 | 2006-04-13 | ギブン・イメージング・リミテツド | Immobilizable in vivo sensing device |
AU2003288517A1 (en) * | 2002-12-26 | 2004-07-22 | Given Imaging Ltd. | In vivo imaging device and method of manufacture thereof |
KR100522132B1 (en) * | 2003-01-25 | 2005-10-18 | 한국과학기술연구원 | Data receiving method and apparatus in human body communication system |
IL161096A (en) | 2003-03-27 | 2008-08-07 | Given Imaging Ltd | Device, system and method for measuring a gradient in-vivo |
GB0307715D0 (en) | 2003-04-03 | 2003-05-07 | Ethicon Endo Surgery Inc | Guide wire structure for insertion into an internal space |
DE10317368B4 (en) * | 2003-04-15 | 2005-04-21 | Siemens Ag | Wireless endoscopy apparatus and method of operating the same |
AU2004233668B2 (en) * | 2003-04-25 | 2008-02-28 | Olympus Corporation | Capsule endoscope and capsule endoscope system |
ATE553690T1 (en) * | 2003-05-01 | 2012-05-15 | Given Imaging Ltd | PANORAMA FIELD OF VIEW DISPLAY DEVICE |
WO2005000101A2 (en) * | 2003-06-12 | 2005-01-06 | University Of Utah Research Foundation | Apparatus, systems and methods for diagnosing carpal tunnel syndrome |
US7460896B2 (en) * | 2003-07-29 | 2008-12-02 | Given Imaging Ltd. | In vivo device and method for collecting oximetry data |
JP4436631B2 (en) | 2003-08-04 | 2010-03-24 | オリンパス株式会社 | Capsule endoscope |
US8021356B2 (en) * | 2003-09-29 | 2011-09-20 | Olympus Corporation | Capsule medication administration system, medication administration method using capsule medication administration system, control method for capsule medication administration system |
JP2005131012A (en) * | 2003-10-29 | 2005-05-26 | Olympus Corp | Capsule medication system |
JP4868720B2 (en) * | 2004-05-27 | 2012-02-01 | オリンパス株式会社 | Capsule dosing system |
JP4733918B2 (en) * | 2003-10-01 | 2011-07-27 | オリンパス株式会社 | Capsule dosing system |
US20050124875A1 (en) * | 2003-10-01 | 2005-06-09 | Olympus Corporation | Vivo observation device |
US7319781B2 (en) * | 2003-10-06 | 2008-01-15 | Carestream Health, Inc. | Method and system for multiple passes diagnostic alignment for in vivo images |
US20050075537A1 (en) * | 2003-10-06 | 2005-04-07 | Eastman Kodak Company | Method and system for real-time automatic abnormality detection for in vivo images |
WO2005053518A1 (en) * | 2003-12-05 | 2005-06-16 | Olympus Corporation | Display processing device |
US7427024B1 (en) | 2003-12-17 | 2008-09-23 | Gazdzinski Mark J | Chattel management apparatus and methods |
US20050137468A1 (en) * | 2003-12-18 | 2005-06-23 | Jerome Avron | Device, system, and method for in-vivo sensing of a substance |
US8639314B2 (en) | 2003-12-24 | 2014-01-28 | Given Imaging Ltd. | Device, system and method for in-vivo imaging of a body lumen |
JP2005185567A (en) * | 2003-12-25 | 2005-07-14 | Olympus Corp | Medical capsule apparatus |
US7647090B1 (en) * | 2003-12-30 | 2010-01-12 | Given Imaging, Ltd. | In-vivo sensing device and method for producing same |
US8164672B2 (en) | 2003-12-31 | 2012-04-24 | Given Imaging Ltd. | System and method for displaying an image stream |
US7968851B2 (en) | 2004-01-13 | 2011-06-28 | Spectrum Dynamics Llc | Dynamic spect camera |
WO2005067817A1 (en) | 2004-01-13 | 2005-07-28 | Remon Medical Technologies Ltd | Devices for fixing a sensor in a body lumen |
WO2008010227A2 (en) | 2006-07-19 | 2008-01-24 | Spectrum Dynamics Llc | Imaging protocols |
US9470801B2 (en) | 2004-01-13 | 2016-10-18 | Spectrum Dynamics Llc | Gating with anatomically varying durations |
JP2007525261A (en) * | 2004-01-16 | 2007-09-06 | ザ シティ カレッジ オブ ザ シティ ユニバーシティ オブ ニューヨーク | A microscale compact device for in vivo medical diagnostics combining optical imaging and point fluorescence spectroscopy |
US7623690B2 (en) * | 2004-03-30 | 2009-11-24 | Carestream Health, Inc. | System and method for classifying in vivo images according to anatomical structure |
WO2005113051A2 (en) | 2004-05-14 | 2005-12-01 | Ethicon Endo-Surgery, Inc. | Medical instrument having a medical guidewire |
EP1757099A4 (en) * | 2004-05-17 | 2009-05-20 | Given Imaging Ltd | Method, system and device for in-vivo biopsy |
WO2006005075A2 (en) * | 2004-06-30 | 2006-01-12 | Amir Belson | Apparatus and methods for capsule endoscopy of the esophagus |
US7596403B2 (en) * | 2004-06-30 | 2009-09-29 | Given Imaging Ltd. | System and method for determining path lengths through a body lumen |
US8500630B2 (en) * | 2004-06-30 | 2013-08-06 | Given Imaging Ltd. | In vivo device with flexible circuit board and method for assembly thereof |
CN101669807B (en) * | 2004-08-23 | 2013-08-21 | 奥林巴斯株式会社 | Image display device, image display method and image display program |
US9316743B2 (en) | 2004-11-09 | 2016-04-19 | Biosensors International Group, Ltd. | System and method for radioactive emission measurement |
US9943274B2 (en) | 2004-11-09 | 2018-04-17 | Spectrum Dynamics Medical Limited | Radioimaging using low dose isotope |
JP4982966B2 (en) * | 2005-05-18 | 2012-07-25 | ブラザー工業株式会社 | Wireless tag detection system |
EP1676522B1 (en) * | 2004-12-30 | 2008-07-02 | Given Imaging Ltd. | System for locating an in-vivo signal source |
US10390714B2 (en) | 2005-01-12 | 2019-08-27 | Remon Medical Technologies, Ltd. | Devices for fixing a sensor in a lumen |
WO2006078902A2 (en) * | 2005-01-19 | 2006-07-27 | Dermaspect, Llc | Devices and methods for identifying and monitoring changes of a suspect area on a patient |
US20060217593A1 (en) * | 2005-03-24 | 2006-09-28 | Zvika Gilad | Device, system and method of panoramic multiple field of view imaging |
IL167782A (en) | 2005-03-31 | 2011-12-29 | Given Imaging Ltd | Antenna for in-vivo imaging system |
JP4970737B2 (en) * | 2005-04-14 | 2012-07-11 | オリンパスメディカルシステムズ株式会社 | Simple image display device and receiving system |
US8837793B2 (en) | 2005-07-19 | 2014-09-16 | Biosensors International Group, Ltd. | Reconstruction stabilizer and active vision |
US9047746B1 (en) | 2005-07-20 | 2015-06-02 | Neil Euliano | Electronic medication compliance monitoring system and associated methods |
CA2616010C (en) * | 2005-07-20 | 2013-11-05 | Neil R. Euliano | Medication compliance system and associated methods |
IL177045A (en) | 2005-07-25 | 2012-12-31 | Daniel Gat | Device, system and method of receiving and recording and displaying in-vivo data with user entered data |
EP1920418A4 (en) * | 2005-09-01 | 2010-12-29 | Proteus Biomedical Inc | Implantable zero-wire communications system |
US8036615B2 (en) | 2005-09-02 | 2011-10-11 | Olympus Corporation | Portable simplified image display apparatus and receiving system |
JP4594834B2 (en) * | 2005-09-09 | 2010-12-08 | オリンパスメディカルシステムズ株式会社 | Image display device |
EP1959830A4 (en) * | 2005-12-02 | 2010-01-06 | Given Imaging Ltd | System and device for in vivo procedures |
US9320417B2 (en) | 2005-12-29 | 2016-04-26 | Given Imaging Ltd. | In-vivo optical imaging device with backscatter blocking |
US8060214B2 (en) * | 2006-01-05 | 2011-11-15 | Cardiac Pacemakers, Inc. | Implantable medical device with inductive coil configurable for mechanical fixation |
ES2405879T3 (en) | 2006-03-13 | 2013-06-04 | Given Imaging Ltd. | Device, system and method for automatic detection of contractile activity in an image frame |
US8441530B2 (en) | 2006-03-13 | 2013-05-14 | Given Imaging Ltd. | Cascade analysis for intestinal contraction detection |
JP4914634B2 (en) * | 2006-04-19 | 2012-04-11 | オリンパスメディカルシステムズ株式会社 | Capsule medical device |
US8894974B2 (en) | 2006-05-11 | 2014-11-25 | Spectrum Dynamics Llc | Radiopharmaceuticals for diagnosis and therapy |
EP2032015A4 (en) | 2006-06-12 | 2010-01-20 | Given Imaging Ltd | Device, system and method for measurement and analysis of contractile activity |
US8043209B2 (en) | 2006-06-13 | 2011-10-25 | Given Imaging Ltd. | System and method for transmitting the content of memory storage in an in-vivo sensing device |
JP2009541298A (en) * | 2006-06-20 | 2009-11-26 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Electronic capsule for treating gastrointestinal disorders |
US7616982B1 (en) * | 2006-06-22 | 2009-11-10 | United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Determination and application of location and angular orientation of a pill transmitter within a body |
US8771176B2 (en) * | 2006-07-24 | 2014-07-08 | Koninklijke Philips N.V. | Capsule camera with variable illumination of the surrounding tissue |
US8002714B2 (en) | 2006-08-17 | 2011-08-23 | Ethicon Endo-Surgery, Inc. | Guidewire structure including a medical guidewire and method for using a medical instrument |
US8715205B2 (en) | 2006-08-25 | 2014-05-06 | Cook Medical Tecnologies Llc | Loop tip wire guide |
US8512241B2 (en) * | 2006-09-06 | 2013-08-20 | Innurvation, Inc. | Methods and systems for acoustic data transmission |
WO2008030480A2 (en) | 2006-09-06 | 2008-03-13 | Innurvation, Inc. | Ingestible low power sensor device and system for communicating with same |
US20080064938A1 (en) * | 2006-09-08 | 2008-03-13 | Semler John R | Method of determining location of an ingested capsule |
US8676349B2 (en) | 2006-09-15 | 2014-03-18 | Cardiac Pacemakers, Inc. | Mechanism for releasably engaging an implantable medical device for implantation |
US8057399B2 (en) | 2006-09-15 | 2011-11-15 | Cardiac Pacemakers, Inc. | Anchor for an implantable sensor |
WO2008075362A2 (en) | 2006-12-20 | 2008-06-26 | Spectrum Dynamics Llc | A method, a system, and an apparatus for using and processing multidimensional data |
WO2008105539A1 (en) * | 2007-03-01 | 2008-09-04 | Olympus Medical Systems Corp. | Device for checking for lumen passage, method of checking for lumen passage and method of producing device for checking for lumen passage |
US8204599B2 (en) | 2007-05-02 | 2012-06-19 | Cardiac Pacemakers, Inc. | System for anchoring an implantable sensor in a vessel |
US7634318B2 (en) | 2007-06-14 | 2009-12-15 | Cardiac Pacemakers, Inc. | Multi-element acoustic recharging system |
JP2009022446A (en) * | 2007-07-18 | 2009-02-05 | Given Imaging Ltd | System and method for combined display in medicine |
JP2008018254A (en) * | 2007-08-21 | 2008-01-31 | Olympus Corp | Capsule endoscope |
US20090088618A1 (en) | 2007-10-01 | 2009-04-02 | Arneson Michael R | System and Method for Manufacturing a Swallowable Sensor Device |
US9197470B2 (en) | 2007-10-05 | 2015-11-24 | Innurvation, Inc. | Data transmission via multi-path channels using orthogonal multi-frequency signals with differential phase shift keying modulation |
US20090105561A1 (en) * | 2007-10-17 | 2009-04-23 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Medical or veterinary digestive tract utilization systems and methods |
US8707964B2 (en) * | 2007-10-31 | 2014-04-29 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
US8303573B2 (en) | 2007-10-17 | 2012-11-06 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
US8789536B2 (en) | 2007-10-17 | 2014-07-29 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
US20090105532A1 (en) * | 2007-10-22 | 2009-04-23 | Zvika Gilad | In vivo imaging device and method of manufacturing thereof |
US8808276B2 (en) * | 2007-10-23 | 2014-08-19 | The Invention Science Fund I, Llc | Adaptive dispensation in a digestive tract |
US8109920B2 (en) * | 2007-10-31 | 2012-02-07 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
US20090163894A1 (en) * | 2007-10-31 | 2009-06-25 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Medical or veterinary digestive tract utilization systems and methods |
US8808271B2 (en) * | 2007-10-31 | 2014-08-19 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
US8333754B2 (en) * | 2007-10-31 | 2012-12-18 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
US20100268025A1 (en) * | 2007-11-09 | 2010-10-21 | Amir Belson | Apparatus and methods for capsule endoscopy of the esophagus |
US20090137866A1 (en) * | 2007-11-28 | 2009-05-28 | Searete Llc, A Limited Liability Corporation Of The State Delaware | Medical or veterinary digestive tract utilization systems and methods |
US20090149839A1 (en) * | 2007-12-11 | 2009-06-11 | Hyde Roderick A | Treatment techniques using ingestible device |
US8406490B2 (en) | 2008-04-30 | 2013-03-26 | Given Imaging Ltd. | System and methods for determination of procedure termination |
JP5188880B2 (en) * | 2008-05-26 | 2013-04-24 | オリンパスメディカルシステムズ株式会社 | Capsule type medical device and method for charging capsule type medical device |
US8515507B2 (en) * | 2008-06-16 | 2013-08-20 | Given Imaging Ltd. | Device and method for detecting in-vivo pathology |
WO2010005571A2 (en) | 2008-07-09 | 2010-01-14 | Innurvation, Inc. | Displaying image data from a scanner capsule |
EP2296536A1 (en) | 2008-07-15 | 2011-03-23 | Cardiac Pacemakers, Inc. | Implant assist apparatus for acoustically enabled implantable medical device |
DE102008045632A1 (en) * | 2008-09-03 | 2010-03-04 | Siemens Aktiengesellschaft | Cystosope capsule, for urological examination/therapeutic applications, has a sterile and bio-compatible housing containing a sensor unit and a permanent magnet |
KR100892239B1 (en) * | 2009-01-16 | 2009-04-09 | 아이쓰리시스템 주식회사 | Endoscope, endoscope system having the same and control method of endoscope |
US8694129B2 (en) | 2009-02-13 | 2014-04-08 | Cardiac Pacemakers, Inc. | Deployable sensor platform on the lead system of an implantable device |
FR2943524B1 (en) * | 2009-03-30 | 2012-07-13 | Francois Perrard | ACCESSORY FOR OBTAINING A 4D GLOBAL DIRECT VISION OF A MOVING SUBASSEMBLY OF THE LOCOMOTIVE HUMAN BODY APPARATUS BY ULTRASONOGRAPHY |
WO2010117419A2 (en) * | 2009-03-31 | 2010-10-14 | The Smartpill Corporation | Method of determining body exit of an ingested capsule |
EP2422684A4 (en) | 2009-04-20 | 2014-01-29 | Olympus Medical Systems Corp | Subject internal examination system |
US7931149B2 (en) | 2009-05-27 | 2011-04-26 | Given Imaging Ltd. | System for storing and activating an in vivo imaging capsule |
US8516691B2 (en) | 2009-06-24 | 2013-08-27 | Given Imaging Ltd. | Method of assembly of an in vivo imaging device with a flexible circuit board |
US9192353B2 (en) * | 2009-10-27 | 2015-11-24 | Innurvation, Inc. | Data transmission via wide band acoustic channels |
US8911360B2 (en) | 2009-11-20 | 2014-12-16 | Given Imaging Ltd. | System and method for controlling power consumption of an in vivo device |
US8647259B2 (en) | 2010-03-26 | 2014-02-11 | Innurvation, Inc. | Ultrasound scanning capsule endoscope (USCE) |
WO2011135573A1 (en) | 2010-04-28 | 2011-11-03 | Given Imaging Ltd. | System and method for displaying portions of in-vivo images |
US8922633B1 (en) | 2010-09-27 | 2014-12-30 | Given Imaging Ltd. | Detection of gastrointestinal sections and transition of an in-vivo device there between |
US8965079B1 (en) | 2010-09-28 | 2015-02-24 | Given Imaging Ltd. | Real time detection of gastrointestinal sections and transitions of an in-vivo device therebetween |
US8873816B1 (en) | 2011-04-06 | 2014-10-28 | Given Imaging Ltd. | Method and system for identification of red colored pathologies in vivo |
WO2013120184A1 (en) | 2012-02-17 | 2013-08-22 | Micropharma Limited | Ingestible medical device |
US9375202B2 (en) | 2012-05-04 | 2016-06-28 | Given Imaging Ltd. | Device and method for in vivo cytology acquisition |
US10448860B2 (en) * | 2013-03-13 | 2019-10-22 | The Johns Hopkins University | System and method for bioelectric localization and navigation of interventional medical devices |
US9324145B1 (en) | 2013-08-08 | 2016-04-26 | Given Imaging Ltd. | System and method for detection of transitions in an image stream of the gastrointestinal tract |
WO2015029033A1 (en) | 2013-08-29 | 2015-03-05 | Given Imaging Ltd. | System and method for maneuvering coils power optimization |
US10521561B1 (en) | 2013-12-17 | 2019-12-31 | Etectrx, Inc. | Electronic compliance system and associated methods |
US10368780B2 (en) | 2015-05-10 | 2019-08-06 | Check-Cap Ltd. | Body worn antenna |
CN109862821A (en) | 2016-09-09 | 2019-06-07 | 普罗根尼蒂公司 | For delivering the electromechanical Ingestible device that can allot substance |
US11541015B2 (en) | 2017-05-17 | 2023-01-03 | Massachusetts Institute Of Technology | Self-righting systems, methods, and related components |
AU2018269556B2 (en) * | 2017-05-17 | 2024-01-25 | Massachusetts Institute Of Technology | Tissue anchoring articles |
CA3100710A1 (en) | 2018-05-17 | 2019-11-21 | Massachusetts Institute Of Technology | Systems for electrical stimulation |
US20220249814A1 (en) | 2018-11-19 | 2022-08-11 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
US11707610B2 (en) | 2019-12-13 | 2023-07-25 | Biora Therapeutics, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
CN111227768A (en) * | 2020-01-16 | 2020-06-05 | 重庆金山医疗技术研究院有限公司 | Navigation control method and device of endoscope |
JP7457615B2 (en) * | 2020-09-18 | 2024-03-28 | 株式会社日立製作所 | Digestive tract contents collection capsule |
CN112472008A (en) * | 2020-11-02 | 2021-03-12 | 重庆金山医疗器械有限公司 | PH capsule positioning device, method and equipment and readable storage medium |
CN115251807B (en) * | 2022-09-26 | 2022-12-06 | 徐州医科大学 | Capsule endoscope system |
Citations (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3971362A (en) | 1972-10-27 | 1976-07-27 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Miniature ingestible telemeter devices to measure deep-body temperature |
US4239040A (en) * | 1976-10-19 | 1980-12-16 | Kabushiki Kaisha Daini Seikosha | Capsule for medical use |
US4278077A (en) | 1978-07-27 | 1981-07-14 | Olympus Optical Co., Ltd. | Medical camera system |
US4439197A (en) | 1981-03-23 | 1984-03-27 | Olympus Optical Co., Ltd. | Medical capsule device |
DE3440177A1 (en) | 1984-11-02 | 1986-05-15 | Friedrich Dipl.-Ing. 8031 Eichenau Hilliges | Television recording and replay device for endoscopy on human and animal bodies |
US4689621A (en) | 1986-03-31 | 1987-08-25 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Temperature responsive transmitter |
US4803992A (en) | 1980-10-28 | 1989-02-14 | Lemelson Jerome H | Electro-optical instruments and methods for producing same |
US4844076A (en) | 1988-08-26 | 1989-07-04 | The Johns Hopkins University | Ingestible size continuously transmitting temperature monitoring pill |
US5042486A (en) | 1989-09-29 | 1991-08-27 | Siemens Aktiengesellschaft | Catheter locatable with non-ionizing field and method for locating same |
US5081041A (en) | 1990-04-03 | 1992-01-14 | Minnesota Mining And Manufacturing Company | Ionic component sensor and method for making and using same |
JPH04109927A (en) | 1990-08-31 | 1992-04-10 | Toshiba Corp | Electronic endoscope apparatus |
US5109870A (en) | 1988-10-25 | 1992-05-05 | Forschungsgesellschaft Fur Biomedizinische Technik E.V. | Apparatus for and method of motility and peristalsis monitoring |
JPH0515515A (en) | 1991-02-19 | 1993-01-26 | Nissin Electric Co Ltd | Digestive organ system diagnosing apparatus |
US5211165A (en) | 1991-09-03 | 1993-05-18 | General Electric Company | Tracking system to follow the position and orientation of a device with radiofrequency field gradients |
FR2688997A1 (en) | 1992-03-26 | 1993-10-01 | Lambert Alain | Autonomous telemetric capsule for exploring small bowel - contains sampler for carrying out mucous biopsies, radio transmitter and position detector |
US5279607A (en) * | 1991-05-30 | 1994-01-18 | The State University Of New York | Telemetry capsule and process |
US5330427A (en) | 1991-07-02 | 1994-07-19 | Ortho Pharmaceutical Corporation | Prefilled suppository applicator |
JPH06285044A (en) | 1993-04-07 | 1994-10-11 | Olympus Optical Co Ltd | Medical capsule detecting system |
US5395366A (en) | 1991-05-30 | 1995-03-07 | The State University Of New York | Sampling capsule and process |
JPH07111985A (en) | 1993-10-18 | 1995-05-02 | Olympus Optical Co Ltd | Capsule apparatus for medical treatment |
US5429132A (en) | 1990-08-24 | 1995-07-04 | Imperial College Of Science Technology And Medicine | Probe system |
US5479935A (en) | 1993-10-21 | 1996-01-02 | Synectics Medical, Inc. | Ambulatory reflux monitoring system |
US5558640A (en) | 1994-03-17 | 1996-09-24 | Siemens Aktiengesellschaft | System for infusion of medicine into the body of a patient |
US5604531A (en) * | 1994-01-17 | 1997-02-18 | State Of Israel, Ministry Of Defense, Armament Development Authority | In vivo video camera system |
US5800350A (en) | 1993-11-01 | 1998-09-01 | Polartechnics, Limited | Apparatus for tissue type recognition |
US5819736A (en) | 1994-03-24 | 1998-10-13 | Sightline Technologies Ltd. | Viewing method and apparatus particularly useful for viewing the interior of the large intestine |
US5833603A (en) | 1996-03-13 | 1998-11-10 | Lipomatrix, Inc. | Implantable biosensing transponder |
US5837196A (en) | 1996-01-26 | 1998-11-17 | The Regents Of The University Of California | High density array fabrication and readout method for a fiber optic biosensor |
US5913820A (en) | 1992-08-14 | 1999-06-22 | British Telecommunications Public Limited Company | Position location system |
WO1999032028A2 (en) | 1997-12-22 | 1999-07-01 | Given Imaging Ltd. | System and method for in vivo delivery of autonomous capsule |
US5993378A (en) * | 1980-10-28 | 1999-11-30 | Lemelson; Jerome H. | Electro-optical instruments and methods for treating disease |
WO2000022975A1 (en) | 1998-10-22 | 2000-04-27 | Given Imaging Ltd. | A method for delivering a device to a target location |
US6099482A (en) | 1997-08-22 | 2000-08-08 | Innotek Pet Products, Inc. | Ingestible animal temperature sensor |
US6149581A (en) | 1997-06-12 | 2000-11-21 | Klingenstein; Ralph James | Device and method for access to the colon and small bowel of a patient |
WO2001008548A1 (en) | 1999-08-03 | 2001-02-08 | The University College London Hospitals Nhs Trust | Improved passage-travelling device |
US6285897B1 (en) | 1999-04-07 | 2001-09-04 | Endonetics, Inc. | Remote physiological monitoring system |
US20010035902A1 (en) | 2000-03-08 | 2001-11-01 | Iddan Gavriel J. | Device and system for in vivo imaging |
US6324418B1 (en) * | 1997-09-29 | 2001-11-27 | Boston Scientific Corporation | Portable tissue spectroscopy apparatus and method |
US20020001695A1 (en) | 1997-04-14 | 2002-01-03 | Olympus Optical Co., Ltd | Micro-passage element used for fluid analysis |
JP2002010990A (en) | 2000-05-31 | 2002-01-15 | Given Imaging Ltd | Measurement of electric characteristics of tissue |
US20020015952A1 (en) | 1999-07-30 | 2002-02-07 | Anderson Norman G. | Microarrays and their manufacture by slicing |
US6369812B1 (en) * | 1997-11-26 | 2002-04-09 | Philips Medical Systems, (Cleveland), Inc. | Inter-active viewing system for generating virtual endoscopy studies of medical diagnostic data with a continuous sequence of spherical panoramic views and viewing the studies over networks |
US6395562B1 (en) | 1998-04-22 | 2002-05-28 | The Regents Of The University Of California | Diagnostic microarray apparatus |
WO2002055984A2 (en) | 2001-01-16 | 2002-07-18 | Given Imaging Ltd. | A system and method for determining in vivo body lumen conditions |
US20020103417A1 (en) | 1999-03-01 | 2002-08-01 | Gazdzinski Robert F. | Endoscopic smart probe and method |
US6475145B1 (en) | 2000-05-17 | 2002-11-05 | Baymar, Inc. | Method and apparatus for detection of acid reflux |
US20020173718A1 (en) | 2001-05-20 | 2002-11-21 | Mordechai Frisch | Array system and method for locating an in vivo signal source |
US20020177779A1 (en) | 2001-03-14 | 2002-11-28 | Doron Adler | Method and system for detecting colorimetric abnormalities in vivo |
US6488694B1 (en) | 1991-01-28 | 2002-12-03 | Advanced Cardiovascular Systems, Inc. | Stent delivery system |
US20020198439A1 (en) | 2001-06-20 | 2002-12-26 | Olympus Optical Co., Ltd. | Capsule type endoscope |
US20030020810A1 (en) | 2001-07-30 | 2003-01-30 | Olympus Optical Co., Ltd. | Capsule-type medical apparatus |
US20030023150A1 (en) | 2001-07-30 | 2003-01-30 | Olympus Optical Co., Ltd. | Capsule-type medical device and medical system |
JP4109927B2 (en) | 2002-08-20 | 2008-07-02 | セイコークロック株式会社 | Radio correction watch and method |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5969049A (en) * | 1982-10-15 | 1984-04-19 | オリンパス光学工業株式会社 | Endoscope diagnostic system |
JP3050569B2 (en) * | 1990-05-10 | 2000-06-12 | オリンパス光学工業株式会社 | Endoscope image processing device |
US5417210A (en) * | 1992-05-27 | 1995-05-23 | International Business Machines Corporation | System and method for augmentation of endoscopic surgery |
JPH0564661A (en) * | 1991-09-09 | 1993-03-19 | Olympus Optical Co Ltd | Inserter for body cavity |
US5318557A (en) * | 1992-07-13 | 1994-06-07 | Elan Medical Technologies Limited | Medication administering device |
JPH08248326A (en) * | 1995-03-10 | 1996-09-27 | Olympus Optical Co Ltd | Stereoscopic endoscope |
JP3776561B2 (en) * | 1997-05-26 | 2006-05-17 | オリンパス株式会社 | 3D measuring endoscope device |
US6240312B1 (en) * | 1997-10-23 | 2001-05-29 | Robert R. Alfano | Remote-controllable, micro-scale device for use in in vivo medical diagnosis and/or treatment |
US6632175B1 (en) * | 2000-11-08 | 2003-10-14 | Hewlett-Packard Development Company, L.P. | Swallowable data recorder capsule medical device |
IL147221A (en) * | 2001-12-20 | 2010-11-30 | Given Imaging Ltd | Device, system and method for image based size analysis |
US7319781B2 (en) * | 2003-10-06 | 2008-01-15 | Carestream Health, Inc. | Method and system for multiple passes diagnostic alignment for in vivo images |
US7623690B2 (en) * | 2004-03-30 | 2009-11-24 | Carestream Health, Inc. | System and method for classifying in vivo images according to anatomical structure |
-
1998
- 1998-10-22 IL IL126727A patent/IL126727A/en not_active IP Right Cessation
-
1999
- 1999-10-21 WO PCT/IL1999/000554 patent/WO2000022975A1/en active Application Filing
- 1999-10-21 JP JP2000576756A patent/JP4059628B2/en not_active Expired - Fee Related
- 1999-10-21 US US09/807,892 patent/US6950690B1/en not_active Expired - Lifetime
- 1999-10-21 EP EP99951074.6A patent/EP1123035B1/en not_active Expired - Lifetime
- 1999-10-21 AU AU63645/99A patent/AU6364599A/en not_active Abandoned
- 1999-10-21 CA CA002347274A patent/CA2347274C/en not_active Expired - Fee Related
-
2005
- 2005-06-27 US US11/166,141 patent/US7822463B2/en not_active Expired - Fee Related
-
2007
- 2007-03-22 JP JP2007073959A patent/JP4649431B2/en not_active Expired - Fee Related
Patent Citations (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3971362A (en) | 1972-10-27 | 1976-07-27 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Miniature ingestible telemeter devices to measure deep-body temperature |
US4239040A (en) * | 1976-10-19 | 1980-12-16 | Kabushiki Kaisha Daini Seikosha | Capsule for medical use |
US4278077A (en) | 1978-07-27 | 1981-07-14 | Olympus Optical Co., Ltd. | Medical camera system |
US4803992A (en) | 1980-10-28 | 1989-02-14 | Lemelson Jerome H | Electro-optical instruments and methods for producing same |
US5993378A (en) * | 1980-10-28 | 1999-11-30 | Lemelson; Jerome H. | Electro-optical instruments and methods for treating disease |
US4439197A (en) | 1981-03-23 | 1984-03-27 | Olympus Optical Co., Ltd. | Medical capsule device |
DE3440177A1 (en) | 1984-11-02 | 1986-05-15 | Friedrich Dipl.-Ing. 8031 Eichenau Hilliges | Television recording and replay device for endoscopy on human and animal bodies |
US4689621A (en) | 1986-03-31 | 1987-08-25 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Temperature responsive transmitter |
US4844076A (en) | 1988-08-26 | 1989-07-04 | The Johns Hopkins University | Ingestible size continuously transmitting temperature monitoring pill |
US5109870A (en) | 1988-10-25 | 1992-05-05 | Forschungsgesellschaft Fur Biomedizinische Technik E.V. | Apparatus for and method of motility and peristalsis monitoring |
US5042486A (en) | 1989-09-29 | 1991-08-27 | Siemens Aktiengesellschaft | Catheter locatable with non-ionizing field and method for locating same |
US5081041A (en) | 1990-04-03 | 1992-01-14 | Minnesota Mining And Manufacturing Company | Ionic component sensor and method for making and using same |
US5429132A (en) | 1990-08-24 | 1995-07-04 | Imperial College Of Science Technology And Medicine | Probe system |
JPH04109927A (en) | 1990-08-31 | 1992-04-10 | Toshiba Corp | Electronic endoscope apparatus |
US6488694B1 (en) | 1991-01-28 | 2002-12-03 | Advanced Cardiovascular Systems, Inc. | Stent delivery system |
JPH0515515A (en) | 1991-02-19 | 1993-01-26 | Nissin Electric Co Ltd | Digestive organ system diagnosing apparatus |
US5279607A (en) * | 1991-05-30 | 1994-01-18 | The State University Of New York | Telemetry capsule and process |
US5395366A (en) | 1991-05-30 | 1995-03-07 | The State University Of New York | Sampling capsule and process |
US5330427A (en) | 1991-07-02 | 1994-07-19 | Ortho Pharmaceutical Corporation | Prefilled suppository applicator |
US5211165A (en) | 1991-09-03 | 1993-05-18 | General Electric Company | Tracking system to follow the position and orientation of a device with radiofrequency field gradients |
FR2688997A1 (en) | 1992-03-26 | 1993-10-01 | Lambert Alain | Autonomous telemetric capsule for exploring small bowel - contains sampler for carrying out mucous biopsies, radio transmitter and position detector |
US5913820A (en) | 1992-08-14 | 1999-06-22 | British Telecommunications Public Limited Company | Position location system |
JPH06285044A (en) | 1993-04-07 | 1994-10-11 | Olympus Optical Co Ltd | Medical capsule detecting system |
JPH07111985A (en) | 1993-10-18 | 1995-05-02 | Olympus Optical Co Ltd | Capsule apparatus for medical treatment |
US5479935A (en) | 1993-10-21 | 1996-01-02 | Synectics Medical, Inc. | Ambulatory reflux monitoring system |
US5800350A (en) | 1993-11-01 | 1998-09-01 | Polartechnics, Limited | Apparatus for tissue type recognition |
US5604531A (en) * | 1994-01-17 | 1997-02-18 | State Of Israel, Ministry Of Defense, Armament Development Authority | In vivo video camera system |
US5558640A (en) | 1994-03-17 | 1996-09-24 | Siemens Aktiengesellschaft | System for infusion of medicine into the body of a patient |
US5819736A (en) | 1994-03-24 | 1998-10-13 | Sightline Technologies Ltd. | Viewing method and apparatus particularly useful for viewing the interior of the large intestine |
US5837196A (en) | 1996-01-26 | 1998-11-17 | The Regents Of The University Of California | High density array fabrication and readout method for a fiber optic biosensor |
US5833603A (en) | 1996-03-13 | 1998-11-10 | Lipomatrix, Inc. | Implantable biosensing transponder |
US20020001695A1 (en) | 1997-04-14 | 2002-01-03 | Olympus Optical Co., Ltd | Micro-passage element used for fluid analysis |
US6149581A (en) | 1997-06-12 | 2000-11-21 | Klingenstein; Ralph James | Device and method for access to the colon and small bowel of a patient |
US6099482A (en) | 1997-08-22 | 2000-08-08 | Innotek Pet Products, Inc. | Ingestible animal temperature sensor |
US6324418B1 (en) * | 1997-09-29 | 2001-11-27 | Boston Scientific Corporation | Portable tissue spectroscopy apparatus and method |
US6369812B1 (en) * | 1997-11-26 | 2002-04-09 | Philips Medical Systems, (Cleveland), Inc. | Inter-active viewing system for generating virtual endoscopy studies of medical diagnostic data with a continuous sequence of spherical panoramic views and viewing the studies over networks |
WO1999032028A2 (en) | 1997-12-22 | 1999-07-01 | Given Imaging Ltd. | System and method for in vivo delivery of autonomous capsule |
US6395562B1 (en) | 1998-04-22 | 2002-05-28 | The Regents Of The University Of California | Diagnostic microarray apparatus |
WO2000022975A1 (en) | 1998-10-22 | 2000-04-27 | Given Imaging Ltd. | A method for delivering a device to a target location |
US20020103417A1 (en) | 1999-03-01 | 2002-08-01 | Gazdzinski Robert F. | Endoscopic smart probe and method |
US6285897B1 (en) | 1999-04-07 | 2001-09-04 | Endonetics, Inc. | Remote physiological monitoring system |
US20020015952A1 (en) | 1999-07-30 | 2002-02-07 | Anderson Norman G. | Microarrays and their manufacture by slicing |
WO2001008548A1 (en) | 1999-08-03 | 2001-02-08 | The University College London Hospitals Nhs Trust | Improved passage-travelling device |
US20010035902A1 (en) | 2000-03-08 | 2001-11-01 | Iddan Gavriel J. | Device and system for in vivo imaging |
US6475145B1 (en) | 2000-05-17 | 2002-11-05 | Baymar, Inc. | Method and apparatus for detection of acid reflux |
JP2002010990A (en) | 2000-05-31 | 2002-01-15 | Given Imaging Ltd | Measurement of electric characteristics of tissue |
WO2002055984A2 (en) | 2001-01-16 | 2002-07-18 | Given Imaging Ltd. | A system and method for determining in vivo body lumen conditions |
US20020177779A1 (en) | 2001-03-14 | 2002-11-28 | Doron Adler | Method and system for detecting colorimetric abnormalities in vivo |
US20020173718A1 (en) | 2001-05-20 | 2002-11-21 | Mordechai Frisch | Array system and method for locating an in vivo signal source |
US20020198439A1 (en) | 2001-06-20 | 2002-12-26 | Olympus Optical Co., Ltd. | Capsule type endoscope |
US20030020810A1 (en) | 2001-07-30 | 2003-01-30 | Olympus Optical Co., Ltd. | Capsule-type medical apparatus |
US20030023150A1 (en) | 2001-07-30 | 2003-01-30 | Olympus Optical Co., Ltd. | Capsule-type medical device and medical system |
JP4109927B2 (en) | 2002-08-20 | 2008-07-02 | セイコークロック株式会社 | Radio correction watch and method |
Non-Patent Citations (10)
Title |
---|
"Heidelberger Kapsel-ein Kleinstsender fur die pH-Messung im Magen", Lange, et al Ielefunken-Zeitung. Ig 36 (1963) Heft 5, pp. 265-270. |
"New Smart Plastic Has Good Memory" - Turke, 2001. |
"New smart plastic has good memory"-Jurke 2001. |
Heidelberger Kapsel-ein Kleinstsender fur die pH-Messung Im Magen Lange . et al Telefunken-Zeitung Jg 38 (1983) Heft 5, pp. 265-270. |
International Search Report for PCT/IL99/00554 dated Apr. 4, 2000. |
Supplementary Partial European Search Report, Mar. 19, 2004. |
The Radio Pill, Rowlands, et al . British Communication and Electronics, Aug. 1960, pp. 598-601. |
Video Camera to "TAKE" - RF System Lab, Dec. 2001. |
Wellesley company sends body montiors into space-Crum, Apr. 1998. |
Wireless transmission of a color television moving images from the stomach using a mioiature CCD camera light source and microwave transmitter. Swiss CP, Gong F, Mills TN. Gastrointest Endosc 1997;45:AB40. |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8682142B1 (en) | 2010-03-18 | 2014-03-25 | Given Imaging Ltd. | System and method for editing an image stream captured in-vivo |
US10102334B2 (en) | 2010-12-30 | 2018-10-16 | Given Imaging Ltd. | System and method for automatic navigation of a capsule based on image stream captured in-vivo |
US9044543B2 (en) | 2012-07-17 | 2015-06-02 | Elwha Llc | Unmanned device utilization methods and systems |
US9061102B2 (en) | 2012-07-17 | 2015-06-23 | Elwha Llc | Unmanned device interaction methods and systems |
US9254363B2 (en) | 2012-07-17 | 2016-02-09 | Elwha Llc | Unmanned device interaction methods and systems |
US9713675B2 (en) | 2012-07-17 | 2017-07-25 | Elwha Llc | Unmanned device interaction methods and systems |
US9733644B2 (en) | 2012-07-17 | 2017-08-15 | Elwha Llc | Unmanned device interaction methods and systems |
US9798325B2 (en) | 2012-07-17 | 2017-10-24 | Elwha Llc | Unmanned device interaction methods and systems |
US10019000B2 (en) | 2012-07-17 | 2018-07-10 | Elwha Llc | Unmanned device utilization methods and systems |
US9131842B2 (en) | 2012-08-16 | 2015-09-15 | Rock West Solutions, Inc. | System and methods for locating relative positions of multiple patient antennas |
US10045713B2 (en) | 2012-08-16 | 2018-08-14 | Rock West Medical Devices, Llc | System and methods for triggering a radiofrequency transceiver in the human body |
US11058322B2 (en) | 2012-08-16 | 2021-07-13 | Rock West Medical Devices, Llc | System and methods for triggering a radiofrequency transceiver in the human body |
US10945635B2 (en) | 2013-10-22 | 2021-03-16 | Rock West Medical Devices, Llc | Nearly isotropic dipole antenna system |
Also Published As
Publication number | Publication date |
---|---|
JP4649431B2 (en) | 2011-03-09 |
CA2347274C (en) | 2009-05-19 |
IL126727A0 (en) | 1999-08-17 |
JP4059628B2 (en) | 2008-03-12 |
IL126727A (en) | 2006-12-31 |
US20060004285A1 (en) | 2006-01-05 |
EP1123035A4 (en) | 2004-07-07 |
JP2003524448A (en) | 2003-08-19 |
AU6364599A (en) | 2000-05-08 |
JP2007196004A (en) | 2007-08-09 |
US6950690B1 (en) | 2005-09-27 |
WO2000022975A1 (en) | 2000-04-27 |
CA2347274A1 (en) | 2000-04-27 |
EP1123035B1 (en) | 2015-10-14 |
EP1123035A1 (en) | 2001-08-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7822463B2 (en) | Method for delivering a device to a target location | |
Moglia et al. | Recent patents on wireless capsule endoscopy | |
US7245954B2 (en) | Measuring a gradient in-vivo | |
US7596403B2 (en) | System and method for determining path lengths through a body lumen | |
JP4166509B2 (en) | Capsule endoscope | |
EP1676522B1 (en) | System for locating an in-vivo signal source | |
US8428685B2 (en) | System and method for magnetically maneuvering an in vivo device | |
US7942811B2 (en) | Capsulated medical equipment | |
JP5248834B2 (en) | Method of operating a system for modeling the raw tracking curve of an in-vivo device | |
US20050096526A1 (en) | Endoscopy device comprising an endoscopy capsule or an endoscopy head with an image recording device, and imaging method for such an endoscopy device | |
JP4027944B2 (en) | Capsule endoscope | |
US7805178B1 (en) | Device, system and method of receiving and recording and displaying in-vivo data with user entered data | |
JP2004321796A (en) | Computer-aided three dimensional image forming method for capsulated endoscope device, radio endoscope device, and medical technology device | |
WO2005065521A1 (en) | System for sensing movement in subject | |
WO2005063122A1 (en) | System for sensing position in subject | |
JP2004041709A (en) | Capsule medical care device | |
WO2005065523A1 (en) | System for sensing position in subject | |
AU2004201212B2 (en) | A Method for Delivering a Device to a Target Location | |
Filip | Self–stabilizing capsule endoscope for early detection and biopsy of colonic polyps | |
US8155414B2 (en) | Device, system and method of in-vivo varix detection | |
KR20240132913A (en) | Control system and method of capsule endoscopy | |
KR100960777B1 (en) | System and method for acquiring information in living body | |
KR100952033B1 (en) | Device and method for acquiring information in living body |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FPAY | Fee payment |
Year of fee payment: 4 |
|
FEPP | Fee payment procedure |
Free format text: MAINTENANCE FEE REMINDER MAILED (ORIGINAL EVENT CODE: REM.) |
|
LAPS | Lapse for failure to pay maintenance fees |
Free format text: PATENT EXPIRED FOR FAILURE TO PAY MAINTENANCE FEES (ORIGINAL EVENT CODE: EXP.); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |
|
STCH | Information on status: patent discontinuation |
Free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362 |
|
FP | Lapsed due to failure to pay maintenance fee |
Effective date: 20181026 |