US6988015B1 - Bone implant - Google Patents

Bone implant Download PDF

Info

Publication number
US6988015B1
US6988015B1 US10129348 US12934802A US6988015B1 US 6988015 B1 US6988015 B1 US 6988015B1 US 10129348 US10129348 US 10129348 US 12934802 A US12934802 A US 12934802A US 6988015 B1 US6988015 B1 US 6988015B1
Authority
US
Grant status
Grant
Patent type
Prior art keywords
bone
implant
molding
socket
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related, expires
Application number
US10129348
Inventor
Christoph Schöpf
Karl Koschatzky
Rolf-Dieter Kalas
Matthias Löwel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tutogen Medical GmbH
Original Assignee
Tutogen Medical GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608Bone, e.g. demineralised bone matrix [DBM], bone powder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/28Bones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30721Accessories
    • A61F2/30734Modular inserts, sleeves or augments, e.g. placed on proximal part of stem for fixation purposes or wedges for bridging a bone defect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/3094Designing or manufacturing processes
    • A61F2/30942Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/32Joints for the hip
    • A61F2/34Acetabular cups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645Connective tissue
    • A61L27/365Bones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/46Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4603Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
    • A61F2/4609Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof of acetabular cups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108Shapes
    • A61F2002/30199Three-dimensional shapes
    • A61F2002/30242Three-dimensional shapes spherical
    • A61F2002/30245Partial spheres
    • A61F2002/30247Hemispheres or half-spheres
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30604Special structural features of bone or joint prostheses not otherwise provided for modular
    • A61F2002/30616Sets comprising a plurality of prosthetic parts of different sizes or orientations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30721Accessories
    • A61F2/30734Modular inserts, sleeves or augments, e.g. placed on proximal part of stem for fixation purposes or wedges for bridging a bone defect
    • A61F2002/30736Augments or augmentation pieces, e.g. wedges or blocks for bridging a bone defect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30767Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth
    • A61F2/30771Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes, grooves
    • A61F2002/3082Grooves
    • A61F2002/30827Plurality of grooves
    • A61F2002/30831Plurality of grooves perpendicular with respect to each other
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30767Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth
    • A61F2/30771Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes, grooves
    • A61F2002/3085Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes, grooves with a threaded, e.g. self-tapping, bone-engaging surface, e.g. external surface
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/3094Designing or manufacturing processes
    • A61F2/30942Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A61F2002/30948Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using computerized tomography, i.e. CT scans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/3094Designing or manufacturing processes
    • A61F2/30942Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A61F2002/30957Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using a positive or a negative model, e.g. moulds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/32Joints for the hip
    • A61F2/34Acetabular cups
    • A61F2002/344Acetabular cups the inner shell having an inner hip femoral head-receiving cavity offset from its centre line
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063Three-dimensional shapes
    • A61F2230/0071Three-dimensional shapes spherical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00365Proteins; Polypeptides; Degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/02Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Abstract

The inventive bone implant for replacing defective joint sockets comprises a base body (10) consisting of preserved natural spongiosa with an approximately hemispherical cavity (12).

Description

The present invention relates to a bone implant to support the fitting of an artificial socket into a damaged bone.

The loosening of artificial joints, in particular of artificial hip joints, is regularly associated with a loss of bone tissue in the patient. A specific form of this tissue loss is concentric osteolysis all around the normally semi-spherical, artificial acetabulum. The reconstruction of the bone defect is often very difficult and time-consuming, in particular when the bone defect at the rear of the acetabulum includes the inner corticalis. Currently, attempts are being made with great technical and time effort to bridge the bone defect by using metal implants in order to offer the replacement socket a stable support with a large area support at the healthy bone.

In this connection, the currently used methods use a combination of special metal implants and bone blocks, discs and granulate whose required size and quantity can only be determined during surgery. The operation is hereby substantially extended with all the disadvantages for the patient which result from this. Spacers are known from EP 0 834 294 A1 for prosthesis parts which can be cemented into bones and which consist of hardened bone cement.

In DE 195 43 110 1, a sterile bone matter for transplanting is known which is substantially free of fat, connective tissue and cartilage mass.

It is the object of the present invention to provide a bone implant with which the planning and operation time can be dramatically shortened in a replacement of damaged sockets.

This object is satisfied by a method having the features of claim 1.

In accordance with the invention, a standard product is provided which consists of spongeous bone, which maintains its biomechanical properties, is reworkable and can simultaneously serve for the anchoring of a socket. The base body can be inserted into the damaged bone, for example, by press fitting, in a short time, whereupon the socket of the endoprosthesis can be inserted into the cavity of the base body.

By using such a standardized intermediate part of natural spongiosa, which is inserted more or less as an “adapter”, the planning and operation time can be substantially shortened since the carrying out of a plurality of individual measures to eliminate the bone defect and to anchor the joint shell can be dispensed with.

Advantageous embodiments of the invention are described by the description, the figures and the dependent claims.

It can also be advantageous to shape the base body with a structured surface at the outer side for a better fixing in place. It is, however, also possible to form the base body without a special outer structure and to anchor it by a press fitting or by cementing it in.

The bone implant is preferably produced from bovine bone.

The invention also relates to a set consisting of a plurality of bone implants of the said kind, with the bone implants in the set having different, standardized outer dimensions and wall strengths. In this connection, the inner diameters of the respective cavities are matched to the outer diameters of commercial artificial sockets. The planning and operation times can be even further shortened with such a set of bone implants since the surgeon already has bone implants with standardized sizes available which consist of preserved natural spongiosa.

The present invention further relates to a method for producing a bone implant for the installation of an artificial socket into a damaged bone in which a computer tomogram is made from the damaged body bone of the patient with the aid of which an artificial model of the damaged body bone is produced.

The producing of a model of a body bone with the aid of a computer tomogram is generally known.

It is a further object of the present invention to provide a method for the producing of a bone implant with which the planning and operation of a bone defect can be simplified.

The manufacture of the bone implant directly from the data of a computer tomogram is possible. The object can be solved in another way in a method of the kind initially named in that in the region of the bone defect a hardenable moldable mass is filled in at the model, in that the molding composition is shaped such that it forms a reception for an artificial socket, and in that a copy of the molded piece is made on a milling machine by scanning the hardened molded piece, said copy being milled from a piece of preserved spongiosa.

A bone implant gained in this way fits accurately into the bone defect and thus satisfies the demands of a stable, large-area support at the healthy bone. At the same time, possible defects in the rear wall of the acetabulum can be closed in a stable and reliable manner with this bone implant.

When forming a reception for a socket, the planned replacement acetabulum of an endoprosthesis, or a model thereof, can be inserted or pressed into the molding composition to form the outer contour of the socket or of the model in the molding composition.

It is also advantageous to provide means for fixing, i.e. to reproduce these in the molding composition. For this purpose, the most favorable direction of extent of securing elements such as screws or pins can be fixed by pressing pins into the molding composition. The desired or required length of these elements can likewise be fixed in advance. The securing elements then automatically fit correctly by pre-drilling the passages.

The present invention will described in the following by way of example with reference to advantageous embodiments and to the enclosed drawings. There are shown:

FIG. 1 a perspective view of a first embodiment of a bone implant;

FIG. 2 a plan view of the bone implant of FIG. 1;

FIG. 3 a plan view of a further embodiment of a bone implant; and

FIG. 4 is a schematic of an inventive method for manufacturing a bone implant.

The bone implant shown in FIG. 1 is an approximately semi-spherical shell 10 made of preserved, natural spongiosa which has a semi-spherical cavity 12. The outer contour of the bone implant 10 and the inner contour of the cavity 12 is thus semi-spherical or at least approximately semi-spherical. The circular aperture of the cavity 12 is surrounded by a peripheral end surface 14 which, in the example shown, has a plurality of radially extending recesses 16 to apply a setting tool.

An outer structure 18 is provided at the semi-spherical outer surface of the bone implant and the bone implant can be anchored in the damaged body with this in that a tool is inserted into the recess 16. The outer structure 18 can be formed as a thread.

FIG. 2 shows a plan view of the bone implant of FIG. 1. As can be recognized, the center of the aperture of the cavity 12 is arranged concentrically to the center of the base body 10.

In the embodiment shown in plan view in FIG. 3, the center of the cavity 12 is, in contrast, arranged offset to the center of the base body 10, i.e. the cavity 12 is arranged eccentrically. In this way, the position of the cavity can be varied by rotation. With this embodiment, which is anchored in the damaged bone by press fit, no outer thread is provided either. The recesses 16 are likewise omitted.

The outer diameters of the bone implants shown can vary in a range from approximately 30 mm to 70 mm. The inner diameters are each matched to commercial outer diameters of artificial joint shells of endoprostheses.

The present invention allows the preparation of the implant support with commercial bone rasps by rasping out the tissue-like structures down to the healthy bone. An implant is possible by press fitting by choosing the matching bone shell, with defects in the rear wall of the acetabulum being closed in a stable manner at the same time. The replacement acetabulum can now be fitted in the bone shell inserted into the damaged bone by press fitting, by cementing in or by screwing. A screw connection can also simultaneously serve for the anchoring of the bone shell in accordance with the invention.

The starting material for the bone implant in accordance with the invention is animal bone from animals of a sufficient size, preferably cows, but also from other animals of a similar size which can be kept under controlled conditions.

To remove the antigenicity, the bone is subjected to an osmotic treatment. Furthermore, an oxidizing treatment is carried out for denaturation of soluble proteins. To optimize virus deactivation, a reduction of pH to pH 3, or a treatment with caustic soda or another substance which destroys DNA/RNA, can take place. The dehydration takes place through organic solvents, preferably acetone. The concluding sterilization takes place through high-energy radiation, preferably γ rays with a maximum dose of 25 kGy. The bone treated in this manner maintains its natural mineral collagen bond and thus its bio-mechanical properties properties, and it can be reworked.

In a method for the manufacture of a bone implant for the replacement of damaged sockets, in accordance with the invention is depicted in FIG. 4 where a computer tomogram is first made from the damaged body bone of the patient with the aid of which an artificial model of the damaged body bone is produced 42. Subsequently, a hardenable molding composition is filled in in the region of the bone defect at the model 44, with the molding composition then being shaped such that it forms a reception for an artificial socket 46. Optionally, the socket of an endoprosthesis or a model of the socket is inserted into the molding composition to form the outer contour of the socket or of the model in the molding composition 48. In this connection, the surgeon fills a preferably self-hardening molding composition into the bone defect at the model and subsequently shapes the mass according to his wants. The artificial socket which should be inserted can be pressed into the molding composition at the desired point and thus be shaped. The fixing of the socket can likewise already be pre-planned.

Optionally, means are provided before the molding composition is hardened into a molded piece for later fixing of the bone implant to the damaged bone body 50.

Subsequently, the molding composition is allowed to set and a bone implant, which corresponds to the hardened formed piece 52, is produced by milling from a sufficiently large piece of preserved spongiosa of natural origin 54 (for example by copy milling) with the aid of the hardened formed piece. The copy of the molded piece is made on a milling machine by scanning the hardened molded piece. The implant gained in this way fits accurately into the defect and meets the demands on a stable, large-area support at the healthy bone. At the same time, possible background defects to the acetabulum can be closed in a stable and reliable manner with this bone implant.

Claims (5)

1. A method for the manufacture of a bone implant for fitting an artificial socket into a damaged bone, in which a computer tomogram is made from the damaged body bone of the patient with the aid of which an artificial model of the damaged body bone is produced, wherein
a) a hardenable molding composition is filled into the region of the bone defect at the model;
b) the molding composition is shaped such that it forms a reception for an artificial socket;
c) the molding composition is hardened into a molded piece; and
d) a copy of the molded piece is made on a milling machine by scanning the hardenable molded piece, said copy being milled from a piece of preserved spongiosa.
2. A method in accordance with claim 1, characterized in that in step b) a socket of an endoprosthesis or a model of the socket is inserted into the molding composition to form the outer contour of the socket or of the model in the molding composition.
3. A method in accordance with claim 1, characterized in that, before step c), means are provided at the molding composition for the later fixing of the bone implant at the damaged body bone.
4. A bone implant comprising a piece of preserved spongiosa maintaining natural mineral collagen bond, the implant being formed by milling said piece of preserved spongiosa based on a molded piece derived from a computer tomogram.
5. The bone implant in accordance with claim 4 wherein the piece of spongiosa is formed to have a semicircular cavity.
US10129348 1999-11-02 2000-10-30 Bone implant Expired - Fee Related US6988015B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE1999152550 DE19952550A1 (en) 1999-11-02 1999-11-02 bone implant
PCT/EP2000/010673 WO2001032107A3 (en) 1999-11-02 2000-10-30 Bone implant

Publications (1)

Publication Number Publication Date
US6988015B1 true US6988015B1 (en) 2006-01-17

Family

ID=7927569

Family Applications (1)

Application Number Title Priority Date Filing Date
US10129348 Expired - Fee Related US6988015B1 (en) 1999-11-02 2000-10-30 Bone implant

Country Status (5)

Country Link
US (1) US6988015B1 (en)
EP (1) EP1225848B1 (en)
CA (1) CA2389628C (en)
DE (1) DE19952550A1 (en)
WO (1) WO2001032107A3 (en)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060100498A1 (en) * 2002-07-19 2006-05-11 Boyce Todd M Process for selecting bone for transplantation
US20080294270A1 (en) * 2007-05-24 2008-11-27 Zimmer Orthobiologics, Inc. Differentially processed tissue and processing methods thereof
US20090054906A1 (en) * 2007-08-24 2009-02-26 Zimmer Orthobiologics, Inc. Medical device and method for delivering an implant to an anatomical site
US20090228031A1 (en) * 2008-03-10 2009-09-10 Zimmer Orthobiologics, Inc. Instruments and methods used when repairing a defect on a tissue surface
USRE43714E1 (en) 1999-12-15 2012-10-02 Zimmer Orthobiologics, Inc. Preparation for repairing cartilage defects or cartilage/bone defects in human or animal joints
US20130091683A1 (en) * 2010-06-17 2013-04-18 Thomas Gradel Method for producing a ceramic acetabulum
US8435305B2 (en) 2010-08-31 2013-05-07 Zimmer, Inc. Osteochondral graft delivery device and uses thereof
US20140012391A1 (en) * 2011-03-21 2014-01-09 Jossi Holding Ag Joint Socket Implant
US9017334B2 (en) 2009-02-24 2015-04-28 Microport Orthopedics Holdings Inc. Patient specific surgical guide locator and mount
US9113916B2 (en) 2010-08-31 2015-08-25 Zimmer, Inc. Drill bit for osteochondral drilling with guiding element and uses thereof
US9375303B1 (en) 2010-04-15 2016-06-28 Zimmer, Inc. Methods of ordering and manufacturing orthopedic components
US9642632B2 (en) 2009-02-24 2017-05-09 Microport Orthopedics Holdings Inc. Orthopedic surgical guide
US9649117B2 (en) 2009-02-24 2017-05-16 Microport Orthopedics Holdings, Inc. Orthopedic surgical guide

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5362442A (en) 1993-07-22 1994-11-08 2920913 Canada Inc. Method for sterilizing products with gamma radiation
DE19952550A1 (en) 1999-11-02 2001-05-03 Tutogen Medical Gmbh bone implant
DE10126085A1 (en) * 2001-05-29 2002-12-05 Tutogen Medical Gmbh bone implant
US6696060B2 (en) 2001-06-14 2004-02-24 Clearant, Inc. Methods for sterilizing preparations of monoclonal immunoglobulins
FR2827503B1 (en) * 2001-07-23 2003-10-24 Macara Frederique Modular acetabular reconstruction
US6749851B2 (en) 2001-08-31 2004-06-15 Clearant, Inc. Methods for sterilizing preparations of digestive enzymes

Citations (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE7341222U (en) Beck H
GB2093701A (en) 1981-02-25 1982-09-08 Schuett & Grundei Gmbh Improvements in or relating to bonegraft material
US4436684A (en) 1982-06-03 1984-03-13 Contour Med Partners, Ltd. Method of forming implantable prostheses for reconstructive surgery
DE3522196A1 (en) 1985-06-21 1986-02-20 Martin Wilhelm Dr Dr Happel Method of producing joint endoprostheses and osteosynthesis material or other bone substitute adapted to the patient's bone dimensions
US4627853A (en) * 1985-05-29 1986-12-09 American Hospital Supply Corporation Method of producing prostheses for replacement of articular cartilage and prostheses so produced
DE3626549A1 (en) 1986-08-06 1988-02-11 Mecron Med Prod Gmbh A process for the preparation of an endoprosthesis with individual adaptation
DE3205526C2 (en) 1982-02-12 1989-01-26 Mecron Medizinische Produkte Gmbh, 1000 Berlin, De
EP0315283A2 (en) 1987-11-03 1989-05-10 Orthopaedic Technology B.V. A method of shaping an endoprosthesis
DE2906650C2 (en) 1979-02-21 1989-05-24 Pfrimmer-Viggo Gmbh & Co Kg, 8520 Erlangen, De
DE8808699U1 (en) 1988-07-04 1989-08-03 Mecron Medizinische Produkte Gmbh, 1000 Berlin, De
EP0328478A1 (en) 1988-02-09 1989-08-16 Mecron Medizinische Produkte Gmbh Acetabular cup
FR2633823A1 (en) 1988-07-07 1990-01-12 Osteal Medical Laboratoires Bone cotyle support ring for hip prosthesis
US4976737A (en) * 1988-01-19 1990-12-11 Research And Education Institute, Inc. Bone reconstruction
DE9109121U1 (en) 1990-08-08 1991-10-10 Howmedica International Inc., Shannon, Clare, Ie
US5139527A (en) * 1987-12-17 1992-08-18 Immuno Aktiengesellschaft Biologic absorbable implant material for filling and closing soft tissue cavities and method of its preparation
US5156777A (en) 1991-03-21 1992-10-20 Kaye Alan H Process for making a prosthetic implant
DE4130546C2 (en) 1990-01-12 1993-10-21 Baylink David J Use of a bone growth promoting composition
EP0574098A1 (en) 1992-06-10 1993-12-15 AMEI TECHNOLOGIES Inc. Method and apparatus for making customized fixation devices
DE9212420U1 (en) 1992-09-15 1994-01-27 Link Waldemar Gmbh Co Socket for a endoprosthetic acetabulum
EP0584484A1 (en) 1992-08-21 1994-03-02 Tulaszewski, Olaf Method and apparatus for disinfecting bone transplants, especially human spongiosa transplants
WO1994009722A1 (en) 1988-03-14 1994-05-11 Thm Biomedical, Inc. Method and device for reconstruction of articular cartilage
DE4341367C1 (en) 1993-12-04 1995-06-14 Harald Dr Med Dr Med Eufinger A process for the production of endoprostheses
WO1995032623A1 (en) 1994-05-27 1995-12-07 Regen Biologics, Inc. Meniscal augmentation device
DE19624118A1 (en) 1995-06-16 1996-12-19 Tornier Sa Hip joint acetabular implant
DE19543110A1 (en) 1995-11-18 1997-06-12 Guy Florian Draenert Sterile, diced, spongy bone material for use in transplantation is freed of fat, connective tissue and cartilage
US5735277A (en) * 1994-09-27 1998-04-07 Schuster; Luis Method of producing an endoprosthesis as a joint substitute for knee-joints
EP0834294A1 (en) 1996-10-07 1998-04-08 Sulzer Orthopädie AG Cemented modular prosthesis
WO1998014128A1 (en) 1996-09-30 1998-04-09 Integrated Surgical Systems, Inc. System and method for cavity generation for surgical planning and initial placement of a bone prosthesis
US5741215A (en) * 1993-09-10 1998-04-21 The University Of Queensland Stereolithographic anatomical modelling process
DE19701778A1 (en) 1996-11-21 1998-06-10 Plus Endoprothetik Ag Acetabular cup for hip joint
US5899939A (en) * 1998-01-21 1999-05-04 Osteotech, Inc. Bone-derived implant for load-supporting applications
DE19751284A1 (en) 1997-11-19 1999-05-27 Leo Prof Dr Gotzen fixation element
DE19815329A1 (en) 1998-04-06 1999-10-07 Peter Brehm Acetabular reconstruction ring for plastics hip joint cup hold
US6118043A (en) * 1991-06-26 2000-09-12 Merck Patent Gesellschaft Mit Beschrankter Haftung Bone replacement material with FGF
WO2000074741A2 (en) 1999-06-08 2000-12-14 Universitätsklinikum Freiburg Biological joint construct
DE19952550A1 (en) 1999-11-02 2001-05-03 Tutogen Medical Gmbh bone implant
US6254639B1 (en) * 1996-09-25 2001-07-03 Ninian Peckitt Prosthetic implants
US6413089B1 (en) * 1999-02-10 2002-07-02 Arthur Ashman Immediate post-extraction implant
US6506217B1 (en) * 1999-03-29 2003-01-14 Arnett Facial Reconstruction Courses, Inc. Moldable post-implantation bone filler and method
US6605117B2 (en) * 1990-05-29 2003-08-12 Stryker Corporation Synthetic bone matrix
US6719793B2 (en) * 1995-07-18 2004-04-13 Iowa State University Research Foundation, Inc. Method of restructuring bone

Patent Citations (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE7341222U (en) Beck H
DE2906650C2 (en) 1979-02-21 1989-05-24 Pfrimmer-Viggo Gmbh & Co Kg, 8520 Erlangen, De
GB2093701A (en) 1981-02-25 1982-09-08 Schuett & Grundei Gmbh Improvements in or relating to bonegraft material
DE3205526C2 (en) 1982-02-12 1989-01-26 Mecron Medizinische Produkte Gmbh, 1000 Berlin, De
US4436684B1 (en) 1982-06-03 1988-05-31
US4436684A (en) 1982-06-03 1984-03-13 Contour Med Partners, Ltd. Method of forming implantable prostheses for reconstructive surgery
US4627853A (en) * 1985-05-29 1986-12-09 American Hospital Supply Corporation Method of producing prostheses for replacement of articular cartilage and prostheses so produced
DE3522196A1 (en) 1985-06-21 1986-02-20 Martin Wilhelm Dr Dr Happel Method of producing joint endoprostheses and osteosynthesis material or other bone substitute adapted to the patient's bone dimensions
DE3626549A1 (en) 1986-08-06 1988-02-11 Mecron Med Prod Gmbh A process for the preparation of an endoprosthesis with individual adaptation
EP0315283A2 (en) 1987-11-03 1989-05-10 Orthopaedic Technology B.V. A method of shaping an endoprosthesis
US5139527A (en) * 1987-12-17 1992-08-18 Immuno Aktiengesellschaft Biologic absorbable implant material for filling and closing soft tissue cavities and method of its preparation
US4976737A (en) * 1988-01-19 1990-12-11 Research And Education Institute, Inc. Bone reconstruction
EP0328478A1 (en) 1988-02-09 1989-08-16 Mecron Medizinische Produkte Gmbh Acetabular cup
WO1994009722A1 (en) 1988-03-14 1994-05-11 Thm Biomedical, Inc. Method and device for reconstruction of articular cartilage
DE8808699U1 (en) 1988-07-04 1989-08-03 Mecron Medizinische Produkte Gmbh, 1000 Berlin, De
FR2633823A1 (en) 1988-07-07 1990-01-12 Osteal Medical Laboratoires Bone cotyle support ring for hip prosthesis
DE4130546C2 (en) 1990-01-12 1993-10-21 Baylink David J Use of a bone growth promoting composition
US6605117B2 (en) * 1990-05-29 2003-08-12 Stryker Corporation Synthetic bone matrix
EP0472315A1 (en) 1990-08-08 1992-02-26 Howmedica International Inc. Acetabular cup for use in a total hip prosthesis
DE9109121U1 (en) 1990-08-08 1991-10-10 Howmedica International Inc., Shannon, Clare, Ie
US5156777A (en) 1991-03-21 1992-10-20 Kaye Alan H Process for making a prosthetic implant
US6118043A (en) * 1991-06-26 2000-09-12 Merck Patent Gesellschaft Mit Beschrankter Haftung Bone replacement material with FGF
US5452407A (en) * 1992-06-10 1995-09-19 Amei Technologies Inc. Method for representing a patient's treatment site as data for use with a CAD or CAM device
EP0574098A1 (en) 1992-06-10 1993-12-15 AMEI TECHNOLOGIES Inc. Method and apparatus for making customized fixation devices
EP0584484A1 (en) 1992-08-21 1994-03-02 Tulaszewski, Olaf Method and apparatus for disinfecting bone transplants, especially human spongiosa transplants
DE9212420U1 (en) 1992-09-15 1994-01-27 Link Waldemar Gmbh Co Socket for a endoprosthetic acetabulum
US5741215A (en) * 1993-09-10 1998-04-21 The University Of Queensland Stereolithographic anatomical modelling process
US6112109A (en) * 1993-09-10 2000-08-29 The University Of Queensland Constructive modelling of articles
DE4341367C1 (en) 1993-12-04 1995-06-14 Harald Dr Med Dr Med Eufinger A process for the production of endoprostheses
WO1995032623A1 (en) 1994-05-27 1995-12-07 Regen Biologics, Inc. Meniscal augmentation device
US5735277A (en) * 1994-09-27 1998-04-07 Schuster; Luis Method of producing an endoprosthesis as a joint substitute for knee-joints
DE4434539C2 (en) 1994-09-27 1998-06-04 Luis Dr Med Schuster A process for producing an endoprosthesis as articular substitute for knee joints
DE19624118A1 (en) 1995-06-16 1996-12-19 Tornier Sa Hip joint acetabular implant
US6719793B2 (en) * 1995-07-18 2004-04-13 Iowa State University Research Foundation, Inc. Method of restructuring bone
DE19543110A1 (en) 1995-11-18 1997-06-12 Guy Florian Draenert Sterile, diced, spongy bone material for use in transplantation is freed of fat, connective tissue and cartilage
US6254639B1 (en) * 1996-09-25 2001-07-03 Ninian Peckitt Prosthetic implants
WO1998014128A1 (en) 1996-09-30 1998-04-09 Integrated Surgical Systems, Inc. System and method for cavity generation for surgical planning and initial placement of a bone prosthesis
EP0834294A1 (en) 1996-10-07 1998-04-08 Sulzer Orthopädie AG Cemented modular prosthesis
DE19701778A1 (en) 1996-11-21 1998-06-10 Plus Endoprothetik Ag Acetabular cup for hip joint
DE19751284A1 (en) 1997-11-19 1999-05-27 Leo Prof Dr Gotzen fixation element
US5899939A (en) * 1998-01-21 1999-05-04 Osteotech, Inc. Bone-derived implant for load-supporting applications
DE19815329A1 (en) 1998-04-06 1999-10-07 Peter Brehm Acetabular reconstruction ring for plastics hip joint cup hold
US6413089B1 (en) * 1999-02-10 2002-07-02 Arthur Ashman Immediate post-extraction implant
US6506217B1 (en) * 1999-03-29 2003-01-14 Arnett Facial Reconstruction Courses, Inc. Moldable post-implantation bone filler and method
WO2000074741A2 (en) 1999-06-08 2000-12-14 Universitätsklinikum Freiburg Biological joint construct
DE19952550A1 (en) 1999-11-02 2001-05-03 Tutogen Medical Gmbh bone implant

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Implantate zur Armierung der Huftpfanne" from Protek AG, Bern, 1971, no translation.
H.H. Lubinus et al. "Ein Pfannenring mit Pfeilerschrauben zur Uberbruckung von Knochendefekten im Acetabulum" Chirurg (1989) 60:819-820, no translation.

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE43714E1 (en) 1999-12-15 2012-10-02 Zimmer Orthobiologics, Inc. Preparation for repairing cartilage defects or cartilage/bone defects in human or animal joints
US8750960B2 (en) * 2002-07-19 2014-06-10 Warsaw Orthopedic, Inc. Process for selecting bone for transplantation
US20060100498A1 (en) * 2002-07-19 2006-05-11 Boyce Todd M Process for selecting bone for transplantation
US20080294270A1 (en) * 2007-05-24 2008-11-27 Zimmer Orthobiologics, Inc. Differentially processed tissue and processing methods thereof
US20090054906A1 (en) * 2007-08-24 2009-02-26 Zimmer Orthobiologics, Inc. Medical device and method for delivering an implant to an anatomical site
US20090228031A1 (en) * 2008-03-10 2009-09-10 Zimmer Orthobiologics, Inc. Instruments and methods used when repairing a defect on a tissue surface
US8801725B2 (en) 2008-03-10 2014-08-12 Zimmer Orthobiologics, Inc. Instruments and methods used when repairing a defect on a tissue surface
US9113914B2 (en) 2009-02-24 2015-08-25 Microport Orthopedics Holdings Inc. Method for forming a patient specific surgical guide mount
US9649117B2 (en) 2009-02-24 2017-05-16 Microport Orthopedics Holdings, Inc. Orthopedic surgical guide
US9642632B2 (en) 2009-02-24 2017-05-09 Microport Orthopedics Holdings Inc. Orthopedic surgical guide
US9883870B2 (en) 2009-02-24 2018-02-06 Microport Orthopedics Holdings Inc. Method for forming a patient specific surgical guide mount
US9901353B2 (en) 2009-02-24 2018-02-27 Microport Holdings Inc. Patient specific surgical guide locator and mount
US9566075B2 (en) 2009-02-24 2017-02-14 Microport Orthopedics Holdings Inc. Patient specific surgical guide locator and mount
US9017334B2 (en) 2009-02-24 2015-04-28 Microport Orthopedics Holdings Inc. Patient specific surgical guide locator and mount
US9949747B2 (en) 2009-02-24 2018-04-24 Microport Orthopedics Holdings, Inc. Systems and methods for installing an orthopedic implant
US9375303B1 (en) 2010-04-15 2016-06-28 Zimmer, Inc. Methods of ordering and manufacturing orthopedic components
US9173740B2 (en) * 2010-06-17 2015-11-03 Inventorio Sa Method for producing a ceramic acetabulum
US20130091683A1 (en) * 2010-06-17 2013-04-18 Thomas Gradel Method for producing a ceramic acetabulum
US9113916B2 (en) 2010-08-31 2015-08-25 Zimmer, Inc. Drill bit for osteochondral drilling with guiding element and uses thereof
US8753406B2 (en) 2010-08-31 2014-06-17 Zimmer Inc. Osteochondral graft delivery device and uses thereof
US8435305B2 (en) 2010-08-31 2013-05-07 Zimmer, Inc. Osteochondral graft delivery device and uses thereof
US20140012391A1 (en) * 2011-03-21 2014-01-09 Jossi Holding Ag Joint Socket Implant
US9198761B2 (en) * 2011-03-21 2015-12-01 Jossi Holding Ag Joint socket implant

Also Published As

Publication number Publication date Type
CA2389628A1 (en) 2001-05-10 application
EP1225848B1 (en) 2005-06-15 grant
WO2001032107A2 (en) 2001-05-10 application
EP1225848A2 (en) 2002-07-31 application
DE19952550A1 (en) 2001-05-03 application
CA2389628C (en) 2007-03-13 grant
WO2001032107A3 (en) 2002-04-04 application

Similar Documents

Publication Publication Date Title
US5002578A (en) Modular hip stem prosthesis apparatus and method
US5176711A (en) Acetabular revision system
US6375684B1 (en) Hip prosthesis and method for fitting such hip prosthesis
US5376125A (en) Hip joint endoprosthesis
US5053049A (en) Flexible prostheses of predetermined shapes and process for making same
US6143030A (en) Impaction allograft form and method of orthopaedic surgery using same
US5281226A (en) Missing portion of a tubular bone
US6102955A (en) Surgical method, surgical tool and artificial implants for repairing knee joints
US5549699A (en) Bony fixation and support of a prosthesis
US5116379A (en) Prosthesis
US4589883A (en) Femoral hip prosthesis
US4163292A (en) Hip prosthesis
US4704686A (en) Method of manufacturing of individually formed prothesis or implant
US6126694A (en) Universal distal broach and stem trial
US3874003A (en) Artificial hip joint
US6010535A (en) Joint replacement system
US6458161B1 (en) Method and apparatus for acetabular reconstruction
US5340362A (en) Method and apparatus for cementing intramedullary bone prosthesis
US4728335A (en) Hip prosthesis
US6306171B1 (en) Total elbow arthroplasty system
US5343877A (en) Orthopedic implant and method
US5951606A (en) Centering device for femoral implant and method and apparatus for implementation thereof
US20050244239A1 (en) Method and apparatus for machining a surgical implant
US20030060891A1 (en) Hip replacement system having fat lubricant
US5002579A (en) Prosthesis component and method for its manufacture

Legal Events

Date Code Title Description
AS Assignment

Owner name: TUTOGEN MEDICAL GMBH, GERMANY

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:SCHOPF, CHRISTOPH;KOSCHATZKY, KARL;KALAS, ROLF-DIETER;AND OTHERS;REEL/FRAME:013123/0039;SIGNING DATES FROM 20020603 TO 20020610

FPAY Fee payment

Year of fee payment: 4

SULP Surcharge for late payment

Year of fee payment: 7

FPAY Fee payment

Year of fee payment: 8

FEPP

Free format text: MAINTENANCE FEE REMINDER MAILED (ORIGINAL EVENT CODE: REM.)

LAPS Lapse for failure to pay maintenance fees

Free format text: PATENT EXPIRED FOR FAILURE TO PAY MAINTENANCE FEES (ORIGINAL EVENT CODE: EXP.)

FP Expired due to failure to pay maintenance fee

Effective date: 20180117