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US6231600B1 - Stents with hybrid coating for medical devices - Google Patents

Stents with hybrid coating for medical devices Download PDF

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US6231600B1
US6231600B1 US09320340 US32034099A US6231600B1 US 6231600 B1 US6231600 B1 US 6231600B1 US 09320340 US09320340 US 09320340 US 32034099 A US32034099 A US 32034099A US 6231600 B1 US6231600 B1 US 6231600B1
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coating
agent
stent
crosslinking
groups
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Sheng-Ping Zhong
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Boston Scientific Scimed Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08Materials for coatings
    • A61L31/10Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08Materials for coatings
    • A61L29/085Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/21Acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23Carbohydrates
    • A61L2300/236Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42Anti-thrombotic agents, anticoagulants, anti-platelet agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602Type of release, e.g. controlled, sustained, slow
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606Coatings
    • A61L2300/608Coatings having two or more layers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606Coatings
    • A61L2300/608Coatings having two or more layers
    • A61L2300/61Coatings having two or more layers containing two or more active agents in different layers

Abstract

A device such as a stent is provided with a hybrid coating including a time released, restenosis inhibiting coating and a non-thrombogenic coating to prevent clotting on the device. One first coat or layer includes a polymer, a crosslinking agent, and pacitaxel, analogues, or derivatives thereof. The first coat preferably includes a polymer having Taxol admixed therein so as to be releasable over time. The first coat preferably includes a polyfunctional aziridine as the crosslinking agent. The second coat preferably includes heparin to inhibit clot formation on the device. The crosslinking agent can covalently bond to both the first coat polymer and the second coat heparin. A stent can be provided with a first coat including an aqueous dispersion or emulsion of a polymer and an excess of crosslinking agent. The first coating can be dried, leaving a water insoluble polymer coating. A second aqueous coating including a solution or dispersion of heparin can be applied over the first coating, the heparin becoming covalently bound to the crosslinking agent on the first coating surface. The resulting stent can inhibit restenosis while preventing blood clot formation on the stent.

Description

CROSS REFERENCES TO CO-PENDING APPLICATIONS

The present application is a continuation-in-part of U.S. patent application Ser. No. 08/929,948, filed Sep. 15, 1997, now U.S. Pat. No. 6,048,620 entitled “A Hydrophilic Coating and Substrates, Particularly Medical Devices, Provided with Such A Coating”, which is a divisional of Ser. No. 08/392,141, filed Feb. 22, 1995, now U.S. Pat. No. 5,702,754, issued Dec. 30, 1997, the disclosure of which are incorporated herein by reference.

FIELD OF THE INVENTION

The present invention relates generally to implantable medical devices. More specifically, the present invention relates to vascular or cardiovascular stents having a time-release coating for inhibiting restenosis and a non-thrombogenic coating for inhibiting clot formation on the stent. In particular, the present invention includes stents having a first coating of Taxol admixed with a polymer and a second coating of heparin bonded to the first coating through a crosslinking agent.

BACKGROUND OF THE INVENTION

Vascular disease is a leading cause of death and disability in the developed world. In the United States, more than one half of all deaths are due to cardiovascular disease. Atherosclerosis is the most common form of vascular disease and leads to insufficient blood supply to body organs, which can result in hearts attacks, strokes, and kidney failure. Atherosclerosis is a form of vascular injury in which the vascular smooth muscle cells in the artery wall undergo hyperproliferation and invade and spread into the inner vessel lining, which can make the vessels susceptible to complete blockage when local blood clotting occurs. This can lead to death of the tissue served by that artery. In the case of a coronary artery, this blockage can lead to myocardial infarction and death.

Coronary artery blockage can be treated with coronary artery bypass surgery and/or angioplasty. Both procedures may initially appear to be successful, but are in effect undone by the effect of restenosis or the recurrence of stenosis after such a treatment. Restenosis is believed to include hyperproliferation of vascular smooth muscle cells. In particular, one third of patients treated using angioplasty have restenosis and blockage within 6 months after the procedure.

To prevent vessel blockage from restenosis, stents are used. Stents are nominally tubular structures and can have either solid walls or lattice like walls, and can be either expandable or self-expanding. After angioplasty balloon dilatation, the previously constricted vessel is at least temporarily widened. A stent can be delivered on a catheter and expanded in place or allowed to expand in place against the vessel walls. With the stent in place, restenosis may or may not be inhibited, but the probability and/or degree of blockage is reduced due to the structural strength of the stent opposing the inward force of any restenosis. Restenosis may occur over the length of the stent and be at least partially opposed by the stent. Restenosis may also occur past the ends of the stent, where the inward forces of the stenosis are unopposed.

Therapeutic agents to inhibit restenosis have been used with varying success. Taxol, an antimicrotubule agent isolated from the bark of the western Pacific Yew tree, is especially effective in inhibiting some cancers and is believed to be effective in combating restenosis. Systemic administration of Taxol can have undesirable side effects, making local administration a preferred mode of treatment. Local administration of Taxol may be more effective when carried out over a longer time period, such as a time period at least matching the normal reaction time of the body to the angioplasty. Local administration of Taxol over a period of days or even months may be most effective in inhibiting restenosis. Such a long time period may be provided by a time release delivery system from the stent itself.

Leaving a stent in place for long time periods in contact with the blood stream can subject the stent to thrombus formation, which can also narrow the vessel inside diameter. A stent surface used to release a therapeutic agent such as Taxol may also not inhibit thrombus formation. What would be desirable is a stent having restenosis inhibiting properties and be suitable for being left in place for long periods without acting as a site for thrombus formation.

SUMMARY OF THE INVENTION

The present invention includes a substrate such as a stent body, means for inhibiting restenosis, means for adhering the restenosis inhibiting means to the body, and means for releasing the restenosis inhibiting means over time. The present invention also includes means for rendering the body non-thrombogenic. In one stent, means for inhibiting restenosis includes paclitaxel (taxol), analogues, and/or derivatives thereof. In one stent, means for adhering the restenosis inhibiting means to the body and releasing the restenosis inhibiting means from the body over time includes admixing the restenosis inhibiting means in a polymeric material adhered to the stent body. In one stent, means for rendering the stent non-thrombogenic includes bonding a crosslinking agent to the polymeric material and then bonding a non-thrombogenic material, such as heparin, to the crosslinking agent. In one stent the polyfunctional crosslinking agent includes polyfunctional aziridine, and the polymeric material includes organic acid functional groups capable of forming covalent bonds with the polyfunctional aziridine.

The present invention includes methods for providing a substrate such as a stent with a biocompatible and restenosis inhibiting coating. One method includes coating the substrate with a first aqueous coating composition, the composition including an aqueous dispersion or emulsion of a polymer, a first therapeutic agent, and an excess of a polyfunctional crosslinking agent having functional groups capable of reacting with the polymer. The method can further include drying the first coating composition to obtain a substantially water insoluble coating or layer still including active functional groups. The method further includes forming a biocompatible surface over the first coating composition by contacting the first dried coating composition with a second aqueous coating composition including an aqueous solution or dispersion of a biocompatibility agent, and drying the combined coatings to bind the biocompatibility agent to the excess crosslinking agent. In one method the biocompatibility agent is a non-thrombogenic agent. In one method, the non-thrombogenic agent includes heparin.

In one method, the polymer includes organic acid functional groups such as carboxylic or sulfonic acid and includes a polyfunctional crosslinking agent capable of reacting with the organic acid groups. In one method, the polymer includes water borne polyurethane, the first therapeutic agent includes paclitaxel, analogues, and/or derivatives thereof, the polyfunctional crosslinking agent includes polyfunctional aziridine, and the second aqueous coating composition includes an aqueous solution or dispersion of heparin.

DETAILED DESCRIPTION OF THE INVENTION

The present invention includes a therapeutic, biocompatible coating over a substrate. One article suitable for incorporating the present invention is a stent suitable for implantation within a body vessel such as a coronary blood vessel. A preferred stent made according to the present invention includes a first, restenosis inhibiting therapeutic agent admixed in a polymeric layer which together coat the stent and a second, non-thrombogenic therapeutic agent coating the first coating.

Substrates suitable for incorporating the present invention include, for example, plastics, other polymeric materials, metals, metallic wires, glass and ceramics. A preferred apparatus incorporating the present invention is a stent, in particular a coronary artery stent formed of a metallic material such as Nitinol or stainless steel.

One stent made according to the present invention includes a polymeric layer coating the stent. Polymers having organic acid functional groups are preferred. In particular, organic acid groups such as carboxylic acid or sulfonic acid are preferred. In the present context the term “organic acid group” is meant to include any groupings which contain an organic acidic ionizable hydrogen, such as carboxylic and sulfonic acid groups. The expression “organic acid functional groups” is meant to include any groups which function in a similar manner to organic acid groups under the reaction conditions, for instance metal salts of such acid groups, particularly alkali metal salts like lithium, sodium and potassium salts, and alkaline earth metal salts like calcium or magnesium salts, and quaternary amine salts of such acid groups, particularly quaternary ammonium salts.

The polymer having organic acid functional groups, which is included in the first aqueous coating composition, is selected with due regard for the nature of the substrate to be coated. Typically the polymer in the first coating composition will be selected from homo- and co-polymers including vinylic monomer units, polyurethanes, epoxy resins, and combinations thereof. The polymer in the first coating composition is preferably selected from polyurethanes, polyacrylates, polymethacrylates, poly-isocrotonates, epoxy resins, acrylate-urethane co-polymers, and combinations thereof having organic acid functional groups. In a particularly preferred embodiment of the method according to the invention, the polymer in the first coating composition is selected from homo- and co-polymers having a substantial amount of organic acid functional groups in their structure, which may act as an internal emulsifier. A specific class of polyurethanes which may be used in the first coating composition are the so-called water-borne polyurethanes, among which are the so-called internally emulsified water-borne polyurethane containing carboxylic acid groups and/or sulfonic acid groups, optionally as salts of such groups, as internal emulsifiers are particularly preferred.

Examples of water-borne polyurethanes are those supplied under the tradename NeoRez by Zeneca Resins, for instance NeoRez-940, NeoRez-972, NeoRez-976, and NeoRez-981; under the tradename Sancure by Sanncor, for instance Sancure 2026, Sancure 2710, Sancure 1601, and Sancure 899; under the tradenames U21 and U21X by B.F. Goodrich; and under the tradenames Bayhydrol LS-2033, Bayhydrol LS-2100, Bayhydrol LS-2952, and Bayhydrol LS-2990 by Bayer AG.

Another specific class of polymers which have shown to be particularly useful in the first coating composition are acrylate-urethane co-polymers, for instance the acrylic urethane co-polymer dispersions supplied under the tradenames NeoPac E-106, NeoPac E-121, NeoPac E-130, and NeoRez R-973 by Zeneca Resins.

The concentration of the polymer in the first coating composition is usually from about 2 to about 60% by weight and preferably from about 5 to about 40% by weight calculated as solids of polymer compared to the total weight of the first coating composition.

In addition to one or more polymers having organic acid functional groups, the first aqueous coating composition can comprise one or more polyfunctional crosslinking agents having functional groups being capable of reacting with organic acid groups. Polyfunctional crosslinking agents having functional groups being capable of reacting with organic acid groups are known in the art. For instance such polyfunctional crosslinking agents have been used for external crosslinking of polyurethanes.

Particularly preferred polyfunctional crosslinking agents for use in the method according to the invention are polyfunctional aziridines and polyfunctional carbodimides. Polyfunctional aziridines and polyfunctional carbodimides and their use as crosslinking agents are known in the art.

The crosslinking agent supplied by Zeneca Resins under the tradename NeoCryl CX 100 and the crosslinking agent supplied by EIT Industries under the tradename XAMA-7 are specific examples of polyfunctional aziridine crosslinking agents which may be used in the method according to the invention, and the crosslinking agent supplied by Union Carbide under the tradename Ucarlink XL-29SE is a specific example of a polyfunctional carbodimide crosslinking agent which may be used in the method according to the invention.

Among the polyfunctional aziridines useful in the present invention is the trifunctional aziridine of the following formula:

Figure US06231600-20010515-C00001

The polyfunctional crosslinking agent is preferably a crosslinking agent having more than two functional groups per molecule. Furthermore, it should be noted that a combination of polyfunctional crosslinking agents may be used in the method according to the invention.

The functional groups on the crosslinking agent can serve two purposes. The first purpose is to crosslink the first polymeric coating. The second purpose is to participate in covalent bonding with the organic acid groups present in the second coating. As such, there is preferably sufficient functionality in the crosslinking agent to accomplish both purposes. That is, the amount of crosslinking agent used preferably provides sufficient functional groups to substantially crosslink the first polymeric coating so that enough unreacted functional groups remain to covalently bond to the second layer.

One indication that insufficient functional groups from the crosslinking agent are present is the inadequate bonding of the second layer. This can be evidenced by the lack of wear resistance as such coatings can be easily wiped off the substrate to which they are applied.

The concentration of the crosslinking agent in the first coating composition is usually in the range from about 0.2 to about 30% by weight and preferably in the range from about 0.5 to about 20% by weight.

As is known in the art, the first aqueous coating composition may include other conventional additives like leveling agents, various stabilizers, pH adjustment agents, defoaming agents, cosolvents, etc., if compatible with the intended use of the coated substrate.

The coating of the first aqueous coating composition is preferably dried so as to obtain a substantially water-insoluble coating layer still including functional groups being reactive with organic acid groups. Hereafter, the obtained dried coating is contacted with a second aqueous coating composition comprising an aqueous solution or dispersion of a non-thrombogenic agent, after which the second coating is dried, the non-thrombogenic agent thereby becoming bonded to the polymer of the first coating composition through the crosslinking agent.

A first therapeutic agent is included in the first coating or layer. The first therapeutic agent is preferably a restenosis inhibiting agent. A preferred restenosis inhibiting agent includes a microtubule stabilizing agent such as paclitaxel (taxol), analogues, derivatives, and mixtures thereof. For example, derivatives believed suitable for use in the present invention include 2′-succinyl-taxol, 2′-succinyl-taxol triethanolamine, 2′-glutaryl-taxol, 2′-glutaryl-taxol triethanolamine salt, 2′-O-ester with N-(dimethylaminoethyl) glutamine, and 2′-O-ester with N-(dimethylaminoethyl) glutamide hydrochloride salt.

The first therapeutic agent is preferably mixed with the polymer, water, and crosslinking agent to form an aqueous dispersion or emulsion. The polymeric emulsion or dispersion can be applied to the substrate to be coated and allowed to dry. A preferred method of drying is air drying.

The second coating can be prepared by dissolving heparin in water. In a preferred embodiment, the heparin concentration is between about 0.05 weight percent and about 20 weight percent. In a more preferred embodiment, the heparin concentration is between about 0.5 and about 10 weight percent. In a most preferred embodiment, the heparin concentration is about 2 percent. In one method, the stent or article having the first dried coating is dipped in the heparin solution, taken out and allowed to air dry. The finished coating is subject to ambient temperature or elevated temperature drying in order to allow the heparin to bond to the polymer layer of the first coating composition.

Some methods according to the present invention are effective at relatively low temperatures, and particularly at ambient or room temperature, to allow for use with heat sensitive substrates, pharmacentical agents and biomolecules. In one embodiment of the method according to the invention, the functional groups of the crosslinking agent are capable of reacting with the organic acid functional groups of the polymer in the first coating composition and the organic acid functional groups of the second coating at a temperature in the range of 10° C.-70° C., preferably at a temperature in the range of 15° C.-35° C. Such reactivity of the crosslinking agent makes it possible to coat the substrate at a temperature in the range of 10° C.-70° C., for example at a temperature in the range of 15° C.-35° C., such as at room temperature, although, of course, higher drying temperatures can be used if desired.

The drying time will depend on the drying temperature, higher drying temperatures requiring shorter drying time and vice versa. However, it will be within the ordinary skill of a person skilled in the art to determine a suitable combination of drying temperatures and drying time for a specific coating. In many cases drying at about room temperature for about 12 hours will be adequate.

The preferred result is a water insoluble polymeric layer having a first therapeutic agent admixed therein and able to be released under physiological temperature and pH. The preferred result also contains the crosslinking agent bonded to the polymeric material and having a substantial number of active functional groups remaining and capable of bonding additional material to the first layer. In one embodiment, the aqueous dispersion or emulsion includes polyurethane, taxol, and polyfunctional aziridine.

A second coating or layer can be added to the first layer by preparing an aqueous solution or emulsion of a second therapeutic agent capable of being bound by the crosslinking agent. The second therapeutic agent is preferably a non-thrombogenic agent. A preferred non-thrombogenic agent includes heparin. After the application of the second therapeutic agent, the second layer is allowed to dry.

The article or stent resulting from the above disclosed process includes a first therapeutic agent admixed in a polymeric material which can be released over time under physiological temperature and pH. The article or stent also includes a second therapeutic agent covalently bound to the first layer by a crosslinking agent. The second therapeutic agent preferably has non-thrombogenic properties.

The invention will be further illustrated in the following non-limiting examples representing presently preferred embodiments of the first coating and second coating of the invention.

EXAMPLE 1

A first coating composition is prepared by adding the following ingredients successively to a glass beaker under agitation until thoroughly mixed.

NeoRez R981 20 ml
N-methyl-pyrrolidone (NMP) 10 ml
50% Taxol solution in NMP (g Taxol/ml NMP) 15 ml
Neocryl CX 100  4 ml

NeoRez R981 (from Zeneca Resins) is a polyester-based, aliphatic water-borne polyurethane containing carboxylic acid groups as internal emulsifier, which is stabilized by triethylamine (TEA) and has a solids content of 32% and a pH of 7.5-9.0 at 25° C. It contains a 5.3% N-methyl-pyrrolidone as cosolvent. NeoCryl CX 100 (from Zeneca Resins) is a polyfunction aziridine crosslinking agent. Taxol (from Hauser) is 99.9% dissolved in NMP as stock solution

EXAMPLE 2

In the same manner as in Example 1, a first coating composition is prepared using the following ingredients:

Bayhydrol 121 20 ml
NMP 20 ml
50% Taxol solution in NMP (g Taxol/ml NMP) 25 ml
Neocryl CX 100  2 ml
Ethanol 10 ml

Bayhydrol 121 is an anionic dispersion of an aliphatic polycarbonate urethane polymer in water/n-methyl-2-pyrrolidone. It has a solid content of 35%, and a pH of 7.5-9.0. It contains 15% of n-methyl-2-pyrrolidone. Ethanol is used to adjust the viscosity of the fluid.

EXAMPLE 3

A first coating composition is prepared as described in Example 1, using the following ingredients:

Bayhydrol 121 20 ml
NMP 20 ml
50% Taxol solution in NMP (g Taxol/ml NMP) 25 ml
Ucarlink XL-29SE  2 ml
Ethanol 10 ml
Ucarlink XL-29SE is a polyfunctional carbodiimide, available from Union Carbide.

EXAMPLE 4

A second coating composition is prepared by adding the following ingredients successively to a glass beaker under agitation until thoroughly mixed.

Heparin (from Abbott)  2 g
De-ionized water 20 ml
34% ammonium hydroxide  0.1 ml

EXAMPLE 5

In the same manner as Example 4, a second coating composition is prepared using the following ingredients:

Hyaluronic acid (sodium salt)  2 g
De-ionized water 20 ml
34% ammonium hydroxide  0.1 ml

EXAMPLE 6

In the same manner as Example 4, a second coating is prepared using the following ingredients:

Heparin 2 g
Hyaluronic acid (sodium salt) 1 g
De-ionized water 20 ml
34% ammonium hydroxide 0.1 ml

EXAMPLE 7

A stainless steel stent is cleaned by immersion in isopropanol under ultrasound, then dried. The first coating composition from Example 1 is applied to the stent surface by spraying, and the coating air dried for 10 minutes at ambient temperature. The second coating composition from Example 3 is applied to the stent by spraying, and allowed to air dry at ambient temperature for 10 minutes. The coated stent is then placed in a 50° C. oven overnight.

EXAMPLE 8

A Nitinol self-expanded stent is cleaned in the same manner as in Example 7. The first coating composition from Example 2 is applied to the stent by dipping the stent into the coating solution. The coating is air dried for 5 minutes. The dipping process is repeated 10 times in order to build a thick coating layer on the stent. After the last dip of the first coating composition, the stent is allowed to air dry for 5 minutes, then the second coating composition is applied by dipping. The process is repeated once, then the stent is air dried for 10 minutes. The finish coating is cured under 37° C. for 48 hours.

Numerous advantages of the invention covered by this document have been set forth in the foregoing description. It will be understood, however, that this disclosure is, in many respects, only illustrative. Changes may be made in details, particularly in matters of shape, size, and arrangement of parts without exceeding the scope of the invention. The invention's scope is, of course, defined in the language in which the appended claims are expressed.

Claims (16)

What is claimed is:
1. A stent comprising:
a substantially tubular body;
a first coating disposed over said body, said first coating including a polymeric material, a first therapeutic agent admixed in said polymeric material, and a crosslinking agent; and
a second coating disposed over said first coating including a second therapeutic agent, wherein said crosslinking agent binds said second therapeutic agent to said polymeric material.
2. A stent as recited in claim 1, wherein said second therapeutic agent has non-thrombogenic properties.
3. A stent as recited in claim 1, wherein said second therapeutic agent is covalently bound to said crosslinking agent.
4. A stent as recited in claim 1, said first therapeutic is selected from the group consisting of paclitaxel, paclitaxel analogues, paclitaxel derivatives, and combinations thereof, and said second therapeutic agent includes heparin.
5. A stent as recited in claim 1, wherein said crosslinking agent includes polyfunctional aziridine.
6. A stent comprising:
a substantially tubular body;
means for inhibiting restenosis;
means for adhering said restenosis inhibiting means to said stent body and releasing said restenosis inhibiting means from said stent body over time; and
means for rendering said stent body non-thrombogenic.
7. A stent comprising:
a substantially tubular body;
a polymer having organic acid functional groups;
a first coating layer including a first therapeutic agent admixed with said polymer and a polyfunctional crosslinking agent covalently bonded to said polymer organic acid functional groups; and
a second coating layer disposed over said first coating layer including a second therapeutic agent covalently bonded to said polyfunctional crosslinking agent.
8. A stent as recited in claim 7, wherein said first therapeutic agent is capable of diffusing out of said first layer.
9. A stent as recited in claim 7, wherein said second therapeutic agent is biocompatible with a human blood stream.
10. A stent as recited in claim 7, wherein said first therapeutic agent includes taxol, analogues, or derivatives thereof and said second therapeutic agent has non-thrombogenic properties.
11. A stent as recited in claim 7, wherein said first therapeutic agent includes pacitaxel, analogues, or derivatives thereof, said polymer includes polyurethane, said crosslinking agent includes a polyfunctional aziridine, and said second therapeutic agent includes heparin, wherein said polyfunctional aziridine is covalently bonded to said polyurethane and to said heparin.
12. A method for providing a substrate with a biocompatible and restenosis inhibiting coating comprising the steps of:
coating said substrate with a first aqueous coating composition including a polymer having organic acid functional groups, a first therapeutic agent, an excess of a polyfunctional crosslinking agent having functional groups capable of reacting with organic acid groups;
drying said first coating composition to obtain a substantially water insoluble coating layer still including functional groups being reactive with organic acid groups;
forming a non-thrombogenic surface over said first coating composition by contacting said dried first coating composition with a second aqueous coating composition including heparin; and
drying said second coating, to bond said heparin to said excess crosslinking agent.
13. A method according to claim 12, wherein said organic acid functional groups are selected from the group consisting of free carboxylic and sulfonic acid groups, metal salts of said acid groups, alkali metal salts of said acid groups, and quaternary amine salts of said acid groups.
14. A method according to claim 12, wherein said polyfunctional crosslinking agent is selected from polyfunctional aziridines, polyfunctional carboimides, and combinations thereof.
15. A method according to claim 12, wherein said polymer in said first coating composition is selected from the group consisting of polyurethanes, polyacrylates, polymethacrylates, polyisocrotonates, epoxy resins, acrylate-urethane co-polymers, and combinations thereof.
16. A method according to claim 15, wherein said polymer in the first coating composition selected from the group consisting of acrylate-urethane co-polymers, polyurethane, and mixtures thereof.
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Cited By (326)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020032478A1 (en) * 2000-08-07 2002-03-14 Percardia, Inc. Myocardial stents and related methods of providing direct blood flow from a heart chamber to a coronary vessel
US20020107563A1 (en) * 2001-02-05 2002-08-08 Shanley John F. Expandable medical device with locking mechanism
US20020163504A1 (en) * 2001-03-13 2002-11-07 Pallakoff Matthew G. Hand-held device that supports fast text typing
US20030009214A1 (en) * 1998-03-30 2003-01-09 Shanley John F. Medical device with beneficial agent delivery mechanism
US6517889B1 (en) 2001-11-26 2003-02-11 Swaminathan Jayaraman Process for coating a surface of a stent
US20030031699A1 (en) * 2002-09-30 2003-02-13 Medtronic Minimed, Inc. Polymer compositions containing bioactive agents and methods for their use
US20030054036A1 (en) * 2001-03-13 2003-03-20 Richard Liggins Micellar drug delivery vehicles and precursors thereto and uses thereof
US20030060783A1 (en) * 1999-12-03 2003-03-27 Koole Levinus Hendrik Wire, tube or catheter with hydrophilic coating
US6544544B2 (en) 1993-07-19 2003-04-08 Angiotech Pharmaceuticals, Inc. Anti-angiogenic compositions and methods of use
US20030083740A1 (en) * 2001-10-22 2003-05-01 Chandrashekhar Pathak Liquid and low melting coatings for stents
US20030088307A1 (en) * 2001-11-05 2003-05-08 Shulze John E. Potent coatings for stents
US6569195B2 (en) * 1999-07-02 2003-05-27 Scimed Life Systems, Inc. Stent coating
US20030157170A1 (en) * 2001-03-13 2003-08-21 Richard Liggins Micellar drug delivery vehicles and precursors thereto and uses thereof
US20030163187A1 (en) * 2002-02-25 2003-08-28 Jan Weber Non-invasive heating of implanted vascular treatment device
WO2003077967A1 (en) * 2002-03-16 2003-09-25 Aachen Resonance Entwicklung- Sgesellschaft Für Magnetresonanz - Kompatible Medizinprodukte Mbh Deposition method for endoprostheses provided for constantly administering medicaments
WO2003082268A2 (en) 2002-03-22 2003-10-09 Eisai Co. Ltd Hemiasterlin derivatives and uses thereof in the treatment of cancer
DE10216971A1 (en) * 2002-04-16 2003-10-30 Lothar Sellin Medical implant, e.g. stent, has drug combined directly or by drug release system with biocompatible e.g. hemocompatible surface coating e.g. of carbon, silicon carbide or pyrolytic carbon
WO2003089026A1 (en) * 2002-04-17 2003-10-30 Genzyme Corporation Aziridine compounds and their use in medical devices
US20030203991A1 (en) * 2002-04-30 2003-10-30 Hydromer, Inc. Coating composition for multiple hydrophilic applications
US6641611B2 (en) 2001-11-26 2003-11-04 Swaminathan Jayaraman Therapeutic coating for an intravascular implant
US20030216352A1 (en) * 1998-03-11 2003-11-20 Surface Solutions Laboratories, Inc. Multicomponent complex for use with a substrate
US6656966B2 (en) 2000-06-22 2003-12-02 Nitromed, Inc. Nitrosated and nitrosylated taxanes, compositions and methods of use
WO2004002367A1 (en) * 2002-06-27 2004-01-08 Microport Medical (Shanghai) Co., Ltd. Drug eluting stent
US20040010304A1 (en) * 2002-07-10 2004-01-15 Jan Weber Medical devices and methods of making the same
US20040024450A1 (en) * 2002-04-24 2004-02-05 Sun Biomedical, Ltd. Drug-delivery endovascular stent and method for treating restenosis
US20040030380A1 (en) * 2002-04-24 2004-02-12 Sun Biomedical, Ltd. Drug-delivery endovascular stent and method for treating restenosis
US20040037886A1 (en) * 2002-08-26 2004-02-26 Li-Chien Hsu Drug eluting coatings for medical implants
US20040047978A1 (en) * 2000-08-04 2004-03-11 Hossainy Syed F.A. Composition for coating an implantable prosthesis
US20040047980A1 (en) * 2000-12-28 2004-03-11 Pacetti Stephen D. Method of forming a diffusion barrier layer for implantable devices
US20040052859A1 (en) * 2001-05-09 2004-03-18 Wu Steven Z. Microparticle coated medical device
US20040073294A1 (en) * 2002-09-20 2004-04-15 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
US20040073298A1 (en) * 2001-04-24 2004-04-15 Hossainy Syed Faiyaz Ahmed Coating for a stent and a method of forming the same
US20040072922A1 (en) * 2002-10-09 2004-04-15 Hossainy Syed F.A. Rate limiting barriers for implantable medical devices
US20040087505A1 (en) * 2002-08-20 2004-05-06 Pena Louis A. Synthetic heparin-binding factor analogs
US20040091605A1 (en) * 2002-05-24 2004-05-13 Biotronik Mess- Und Therapiegeraete Gmbh & Co Ingenieurbuero Berlin Method of coating a stent with a polysaccharide layer and associated stents
US20040096504A1 (en) * 2000-12-22 2004-05-20 Gene Michal Ethylene-carboxyl copolymers as drug delivery matrices
US20040127976A1 (en) * 2002-09-20 2004-07-01 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
US20040133268A1 (en) * 1998-01-14 2004-07-08 Advanced Stent Technologies, Inc. Extendible stent apparatus
US20040137066A1 (en) * 2001-11-26 2004-07-15 Swaminathan Jayaraman Rationally designed therapeutic intravascular implant coating
US6764507B2 (en) 2000-10-16 2004-07-20 Conor Medsystems, Inc. Expandable medical device with improved spatial distribution
US20040143321A1 (en) * 2002-11-08 2004-07-22 Conor Medsystems, Inc. Expandable medical device and method for treating chronic total occlusions with local delivery of an angiogenic factor
US20040148016A1 (en) * 2002-11-07 2004-07-29 Klein Dean A. Biocompatible medical device coatings
US20040170752A1 (en) * 2003-02-28 2004-09-02 Luthra Ajay K. Polymeric network system for medical devices and methods of use
US20040185081A1 (en) * 2002-11-07 2004-09-23 Donald Verlee Prosthesis with multiple drugs applied separately by fluid jet application in discrete unmixed droplets
US20040220665A1 (en) * 1999-09-03 2004-11-04 Hossainy Syed F.A. Thermal treatment of a drug eluting implantable medical device
US20040224001A1 (en) * 2003-05-08 2004-11-11 Pacetti Stephen D. Stent coatings comprising hydrophilic additives
US20040225346A1 (en) * 2003-02-05 2004-11-11 Mazumder Mark M. Encased stent
US20040224080A1 (en) * 2003-05-06 2004-11-11 Epstein Samuel J. Processes for producing polymer coatings for release of therapeutic agent
US20040236279A1 (en) * 2003-05-22 2004-11-25 Atrium Medical Corp. Gaseous therapeutic agent delivery
US20040236410A1 (en) * 2003-05-22 2004-11-25 Atrium Medical Corp. Polymeric body formation
US20040236278A1 (en) * 2003-05-22 2004-11-25 Atrium Medical Corp. Therapeutic agent delivery
US20040232587A1 (en) * 2000-10-03 2004-11-25 Atrium Medical Corp. Method for forming expandable polymers having drugs or agents included therewith
US20040249449A1 (en) * 2003-06-05 2004-12-09 Conor Medsystems, Inc. Drug delivery device and method for bi-directional drug delivery
US20040253281A1 (en) * 2003-06-12 2004-12-16 Atrium Medical Corp. Therapeutic markings applied to tissue
US20050004646A1 (en) * 2003-07-01 2005-01-06 Moriarty James W. Energy-activated adhesion layer for drug-polymer coated stent
US20050004651A1 (en) * 1998-09-05 2005-01-06 Abbott Laboratories Vascular Enterprises Limited Methods and apparatus for a stent having an expandable web structure and delivery system
US20050021127A1 (en) * 2003-07-21 2005-01-27 Kawula Paul John Porous glass fused onto stent for drug retention
US20050038505A1 (en) * 2001-11-05 2005-02-17 Sun Biomedical Ltd. Drug-delivery endovascular stent and method of forming the same
US20050070936A1 (en) * 2003-09-30 2005-03-31 Pacetti Stephen D. Coatings for drug delivery devices comprising hydrolitically stable adducts of poly(ethylene-co-vinyl alcohol) and methods for fabricating the same
US20050074544A1 (en) * 2003-10-07 2005-04-07 Pacetti Stephen D. System and method for coating a tubular implantable medical device
US20050100577A1 (en) * 2003-11-10 2005-05-12 Parker Theodore L. Expandable medical device with beneficial agent matrix formed by a multi solvent system
US20050106206A1 (en) * 2003-09-15 2005-05-19 Atrium Medical Corporation Application of a therapeutic substance to a tissue location using an expandable medical device
US20050112172A1 (en) * 2003-11-26 2005-05-26 Pacetti Stephen D. Biobeneficial coating compostions and methods of making and using thereof
US20050113687A1 (en) * 2003-09-15 2005-05-26 Atrium Medical Corporation Application of a therapeutic substance to a tissue location using a porous medical device
US20050143808A1 (en) * 2003-02-26 2005-06-30 Hossainy Syed F.A. Coating for implantable medical devices
US20050147647A1 (en) * 2003-12-24 2005-07-07 Thierry Glauser Coatings for implantable medical devices comprising hydrophilic substances and methods for fabricating the same
US20050169957A1 (en) * 2002-12-11 2005-08-04 Hossainy Syed F. Biocompatible polyacrylate compositions for medical applications
US20050186241A1 (en) * 2000-11-17 2005-08-25 Boyle Christopher T. Device for in vivo delivery of bioactive agents and method of manufacture thereof
US20050196422A1 (en) * 2003-02-26 2005-09-08 Hossainy Syed F. Methods for fabricating a coating for implantable medical devices
US20050208093A1 (en) * 2004-03-22 2005-09-22 Thierry Glauser Phosphoryl choline coating compositions
US20050234544A1 (en) * 2002-09-20 2005-10-20 Conor Medsystems, Inc. Expandable medical device with openings for delivery of multiple beneficial agents
US20050232970A1 (en) * 2004-03-26 2005-10-20 Stucke Sean M Process and systems for biocompatible surfaces
US20050238829A1 (en) * 2004-04-22 2005-10-27 John Motherwell Differentially coated medical devices, system for differentially coating medical devices, and coating method
US20050244453A1 (en) * 2004-03-26 2005-11-03 Stucke Sean M Composition and method for preparing biocompatible surfaces
US20050260557A1 (en) * 2004-05-21 2005-11-24 Mary Zacour Method of quantifying the cell-binding properties of a medical device
US20050261756A1 (en) * 2002-09-03 2005-11-24 Bioneris Ab Coated stent
US20050273161A1 (en) * 2002-11-26 2005-12-08 Advanced Cardiovascular Systems, Inc. Electrostatic loading of drugs on implantable medical devices
WO2005122959A2 (en) 2004-06-08 2005-12-29 Advanced Stent Technologies, Inc. Stent with protruding branch portion for bifurcated vessels
US20060019023A1 (en) * 2001-12-28 2006-01-26 Hossainy Syed F Method of coating implantable medical devices
US20060025726A1 (en) * 1996-06-04 2006-02-02 Vance Products Incorporated, D/B/A Cook Urological Incorporated Implantable medical device with pharmacologically active layer
US20060030826A1 (en) * 1996-06-04 2006-02-09 Vance Products Incorporated,d/b/a Cook Urological Incorporated Implantable medical device with anti-neoplastic drug
US7001421B2 (en) 2003-02-28 2006-02-21 Medtronic Vascular, Inc. Stent with phenoxy primer coating
US20060052757A1 (en) * 1996-06-04 2006-03-09 Vance Products Incorporated, D/B/A Cook Urological Incorporated Implantable medical device with analgesic or anesthetic
US20060064157A1 (en) * 2001-08-20 2006-03-23 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US20060069427A1 (en) * 2004-09-24 2006-03-30 Savage Douglas R Drug-delivery endovascular stent and method for treating restenosis
US20060067952A1 (en) * 2004-09-28 2006-03-30 Sd Pharmaceuticals, Inc. Low oil emulsion compositions for delivering taxoids and other insoluble drugs
US20060105019A1 (en) * 2002-12-16 2006-05-18 Gordon Stewart Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders
US20060112536A1 (en) * 2003-09-15 2006-06-01 Atrium Medical Corporation Method of coating a folded medical device
US7056591B1 (en) 2003-07-30 2006-06-06 Advanced Cardiovascular Systems, Inc. Hydrophobic biologically absorbable coatings for drug delivery devices and methods for fabricating the same
US20060121012A1 (en) * 2000-03-15 2006-06-08 Orbus Medical Technologies, Inc. Medical device with coating for capturing genetically-altered cells and methods of using same
US20060127443A1 (en) * 2004-12-09 2006-06-15 Helmus Michael N Medical devices having vapor deposited nanoporous coatings for controlled therapeutic agent delivery
US20060135476A1 (en) * 2000-03-15 2006-06-22 Orbus Medical Technologies, Inc. Medical device with coating that promotes endothelial cell adherence and differentiation
US20060142541A1 (en) * 2004-12-27 2006-06-29 Hossainy Syed F A Poly(ester amide) block copolymers
US20060149357A1 (en) * 2000-10-16 2006-07-06 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US20060199764A1 (en) * 2002-08-20 2006-09-07 Biosurface Engineering Technologies, Inc. FGF growth factor analogs
US20060239909A1 (en) * 2005-03-22 2006-10-26 President And Fellows Of Harvard College Treatment of protein degradation disorders
US20060257355A1 (en) * 2005-05-10 2006-11-16 Abiomed, Inc. Impregnated polymer compositions and devices using them
US20070031611A1 (en) * 2005-08-04 2007-02-08 Babaev Eilaz P Ultrasound medical stent coating method and device
US20070042017A1 (en) * 2000-03-15 2007-02-22 Orbus Medical Technologies, Inc. Medical device with coating that promotes endothelial cell adherence and differentiation
US20070048351A1 (en) * 2005-09-01 2007-03-01 Prescient Medical, Inc. Drugs coated on a device to treat vulnerable plaque
US20070051307A1 (en) * 2005-08-16 2007-03-08 Babaev Eilaz P Ultrasound apparatus and methods for mixing liquids and coating stents
US20070059530A1 (en) * 2005-09-14 2007-03-15 Ziegler Michael J Multi-component, waterborne coating compositions, related coatings and methods
US20070093413A1 (en) * 1996-03-26 2007-04-26 Harvard University Oti Histone deacetylases, and uses related thereto
WO2007056073A2 (en) * 2005-11-04 2007-05-18 Boston Scientific Limited (Barbados Home Office) Medical device with a coating comprising an active form and an inactive form of therapeutic agent(s)
US7223282B1 (en) 2001-09-27 2007-05-29 Advanced Cardiovascular Systems, Inc. Remote activation of an implantable device
US20070128723A1 (en) * 2000-03-15 2007-06-07 Orbusneich Medical, Inc. Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device
US20070141107A1 (en) * 2000-03-15 2007-06-21 Orbusneich Medical, Inc. Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device
US20070189915A1 (en) * 2002-11-07 2007-08-16 Sanjay Shrivastava Method of integrating therapeutic agent into a bioerodible medical device
WO2007095584A2 (en) 2006-02-14 2007-08-23 The President And Fellows Of Harvard College Histone Deacetylase Inhibitors
US20070207173A1 (en) * 2006-02-01 2007-09-06 Sd Pharmaceuticals, Inc. Vitamin E succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof
EP1832301A2 (en) * 2006-03-08 2007-09-12 Sahajanand Medical Technologies PVT. ltd Coatings for implantable medical devices
WO2007130429A2 (en) 2006-05-03 2007-11-15 The President And Fellows Of Harvard College Histone deacetylase and tubulin deacetylase inhibitors
US20080015500A1 (en) * 1999-01-25 2008-01-17 Atrium Medical Corporation Application of a therapeutic substance to a tissue location using an expandable medical device
US20080027531A1 (en) * 2004-02-12 2008-01-31 Reneker Darrell H Stent for Use in Cardiac, Cranial, and Other Arteries
US7329413B1 (en) 2003-11-06 2008-02-12 Advanced Cardiovascular Systems, Inc. Coatings for drug delivery devices having gradient of hydration and methods for fabricating thereof
US7335391B1 (en) 2001-05-31 2008-02-26 Advanced Cardiovascular Systems, Inc. Method for coating implantable devices
US20080054091A1 (en) * 2005-08-04 2008-03-06 Bacoustics Llc Ultrasonic atomization and/or seperation system
US20080063622A1 (en) * 2003-08-19 2008-03-13 Biosurface Engineering Technologies, Inc. Composition and Method for Delivery of BMP-2 Amplifier/Co-Activator for Enhancement of Osteogenesis
US20080097568A1 (en) * 2006-10-20 2008-04-24 Savage Douglas R Drug-delivery endovascular stent and method of use
US20080097591A1 (en) * 2006-10-20 2008-04-24 Biosensors International Group Drug-delivery endovascular stent and method of use
US20080103584A1 (en) * 2006-10-25 2008-05-01 Biosensors International Group Temporal Intraluminal Stent, Methods of Making and Using
US20080142616A1 (en) * 2006-12-15 2008-06-19 Bacoustics Llc Method of Producing a Directed Spray
US20080145516A1 (en) * 2002-04-04 2008-06-19 Boston Scientific Scimed, Inc. Processes for producing polymer coatings through surface polymerization
US20080160169A1 (en) * 2006-06-22 2008-07-03 Zamora Paul O Coating device and method for coating medical device with bioactive peptide
US20080167431A1 (en) * 2005-09-14 2008-07-10 Ppg Industries Ohio, Inc. Multi-component, waterborne coating compositions, related coatings and methods
WO2008091349A1 (en) 2006-02-14 2008-07-31 The President And Fellows Of Harvard College Bifunctional histone deacetylase inhibitors
CN100413540C (en) 2002-09-03 2008-08-27 微创医疗器械(上海)有限公司 Gene carrying rack and its producing method and use
EP1961401A2 (en) 2007-02-20 2008-08-27 Cardiatis Société Anonyme Hyperplasia plaque-preventing stent
US20080208313A1 (en) * 2007-02-26 2008-08-28 Medtronic Vascular, Inc. Drug Coated Stent With Magnesium Topcoat
US20080227696A1 (en) * 2005-02-22 2008-09-18 Biosurface Engineering Technologies, Inc. Single branch heparin-binding growth factor analogs
US7431959B1 (en) 2003-07-31 2008-10-07 Advanced Cardiovascular Systems Inc. Method and system for irradiation of a drug eluting implantable medical device
EP1977772A2 (en) 2007-03-28 2008-10-08 Cordis Corporation Short term sustained drug-delivery system for implantable medical devices and method of making the same
US7441513B1 (en) 2003-09-26 2008-10-28 Advanced Cardiovascular Systems, Inc. Plasma-generated coating apparatus for medical devices and a method of coating deposition
GB2448871A (en) * 2007-04-30 2008-11-05 Inion Ltd Modulation of inflammatory and immune responses in the treatment of inflammation using substituted heterocyclic compounds
US20080286278A1 (en) * 2001-03-07 2008-11-20 Biomed Solutions, Llc Process for in vivo treatment of specific biological targets in bodily fluids
US20080294240A1 (en) * 2007-05-23 2008-11-27 Abbott Laboratories Vascular Enterprises Limited Flexible stent with torque-absorbing connectors
US7468210B1 (en) 2002-12-10 2008-12-23 Biosurface Engineering Technologies, Inc. Cross-linked heparin coatings and methods
WO2008005284A3 (en) * 2006-06-30 2009-01-29 Cook Inc Methods of manufacturing and modifying taxane coatings for implantable medical devices
EP2019657A2 (en) * 2006-04-26 2009-02-04 Micell Technologies, Inc. Coatings containing multiple drugs
KR100888219B1 (en) 2007-06-01 2009-03-12 (주) 태웅메디칼 Coating agent for drug releasing stent, manufacturing method thereof and drug releasing stent coated with the coating agent
US20090073577A1 (en) * 2007-09-19 2009-03-19 Samsung Electro-Mechanics Co., Ltd. Super wide angle optical system
CN100471469C (en) 2002-06-27 2009-03-25 微创医疗器械(上海)有限公司 Drug-eluting stent (DES) with multicoating
US20090118820A1 (en) * 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US20090118818A1 (en) * 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis with coating
US20090163992A1 (en) * 2007-12-20 2009-06-25 Abbott Laboratories Vascular Enterprises Limited Endoprosthesis having flexible connectors
US7560492B1 (en) 2003-11-25 2009-07-14 Advanced Cardiovascular Systems, Inc. Polysulfone block copolymers as drug-eluting coating material
US7588642B1 (en) 2004-11-29 2009-09-15 Advanced Cardiovascular Systems, Inc. Abluminal stent coating apparatus and method using a brush assembly
US20090292347A1 (en) * 2008-05-21 2009-11-26 Boston Scientific Scimed, Inc. Systems and methods for heating and cooling during stent crimping
US20090305384A1 (en) * 2000-03-03 2009-12-10 President And Fellows Of Harvard College Class II Human Histone Deacetylases, and Uses Related Thereto
CN100569302C (en) 2006-08-25 2009-12-16 许川山 Photo-sensitive stent with restricture-proof function
US7645504B1 (en) * 2003-06-26 2010-01-12 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices comprising hydrophobic and hydrophilic polymers
US7645474B1 (en) 2003-07-31 2010-01-12 Advanced Cardiovascular Systems, Inc. Method and system of purifying polymers for use with implantable medical devices
US7648725B2 (en) 2002-12-12 2010-01-19 Advanced Cardiovascular Systems, Inc. Clamp mandrel fixture and a method of using the same to minimize coating defects
US7648727B2 (en) 2004-08-26 2010-01-19 Advanced Cardiovascular Systems, Inc. Methods for manufacturing a coated stent-balloon assembly
US20100016890A1 (en) * 2008-07-17 2010-01-21 Steve Tsai Spool Dip And Overcoat Process For Medical Devices
US7655030B2 (en) 2003-07-18 2010-02-02 Boston Scientific Scimed, Inc. Catheter balloon systems and methods
US20100063580A1 (en) * 2007-01-08 2010-03-11 Mcclain James B Stents having biodegradable layers
US7678142B2 (en) 1996-11-04 2010-03-16 Boston Scientific Scimed, Inc. Extendible stent apparatus
US7682669B1 (en) 2001-07-30 2010-03-23 Advanced Cardiovascular Systems, Inc. Methods for covalently immobilizing anti-thrombogenic material into a coating on a medical device
US7682648B1 (en) 2000-05-31 2010-03-23 Advanced Cardiovascular Systems, Inc. Methods for forming polymeric coatings on stents
US7691401B2 (en) 2000-09-28 2010-04-06 Advanced Cardiovascular Systems, Inc. Poly(butylmethacrylate) and rapamycin coated stent
US7713637B2 (en) 2006-03-03 2010-05-11 Advanced Cardiovascular Systems, Inc. Coating containing PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid polymer
US20100145251A1 (en) * 2003-02-03 2010-06-10 Hans-Dietrich Polaschegg Prevention of indwelling device related infection: compositions and methods
US7735449B1 (en) 2005-07-28 2010-06-15 Advanced Cardiovascular Systems, Inc. Stent fixture having rounded support structures and method for use thereof
US7749263B2 (en) 2004-10-29 2010-07-06 Abbott Cardiovascular Systems Inc. Poly(ester amide) filler blends for modulation of coating properties
US7753285B2 (en) 2007-07-13 2010-07-13 Bacoustics, Llc Echoing ultrasound atomization and/or mixing system
US7758881B2 (en) 2004-06-30 2010-07-20 Advanced Cardiovascular Systems, Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
US7766955B2 (en) 1996-11-04 2010-08-03 Boston Scientific Scimed, Inc. Extendible stent apparatus
US7766884B2 (en) 2004-08-31 2010-08-03 Advanced Cardiovascular Systems, Inc. Polymers of fluorinated monomers and hydrophilic monomers
US7772359B2 (en) 2003-12-19 2010-08-10 Advanced Cardiovascular Systems, Inc. Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents
US7771462B1 (en) 1999-06-04 2010-08-10 Boston Scientific Scimed, Inc. Catheter with side sheath and methods
US7776926B1 (en) 2002-12-11 2010-08-17 Advanced Cardiovascular Systems, Inc. Biocompatible coating for implantable medical devices
US7775178B2 (en) 2006-05-26 2010-08-17 Advanced Cardiovascular Systems, Inc. Stent coating apparatus and method
US7780095B2 (en) 2007-07-13 2010-08-24 Bacoustics, Llc Ultrasound pumping apparatus
US7785512B1 (en) 2003-07-31 2010-08-31 Advanced Cardiovascular Systems, Inc. Method and system of controlled temperature mixing and molding of polymers with active agents for implantable medical devices
US7785647B2 (en) 2005-07-25 2010-08-31 Advanced Cardiovascular Systems, Inc. Methods of providing antioxidants to a drug containing product
US7794743B2 (en) 2002-06-21 2010-09-14 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of making the same
US7795467B1 (en) 2005-04-26 2010-09-14 Advanced Cardiovascular Systems, Inc. Bioabsorbable, biobeneficial polyurethanes for use in medical devices
US7803394B2 (en) 2002-06-21 2010-09-28 Advanced Cardiovascular Systems, Inc. Polycationic peptide hydrogel coatings for cardiovascular therapy
US7803406B2 (en) 2002-06-21 2010-09-28 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of coating implantable medical devices
US7803183B2 (en) 2000-03-15 2010-09-28 Orbusneich Medical, Inc. Medical device with coating that promotes endothelial cell adherence
US7807211B2 (en) 1999-09-03 2010-10-05 Advanced Cardiovascular Systems, Inc. Thermal treatment of an implantable medical device
US7807210B1 (en) 2000-10-31 2010-10-05 Advanced Cardiovascular Systems, Inc. Hemocompatible polymers on hydrophobic porous polymers
US7811314B2 (en) 1998-09-05 2010-10-12 Abbott Laboratories Vascular Enterprises Limited Methods and apparatus for stenting comprising enhanced embolic protection coupled with improved protections against restenosis and thrombus formation
US7815763B2 (en) 2001-09-28 2010-10-19 Abbott Laboratories Vascular Enterprises Limited Porous membranes for medical implants and methods of manufacture
US7820172B1 (en) 2006-06-01 2010-10-26 Biosurface Engineering Technologies, Inc. Laminin-derived multi-domain peptides
US7820732B2 (en) 2004-04-30 2010-10-26 Advanced Cardiovascular Systems, Inc. Methods for modulating thermal and mechanical properties of coatings on implantable devices
US7820190B2 (en) 2000-12-28 2010-10-26 Advanced Cardiovascular Systems, Inc. Coating for implantable devices and a method of forming the same
US7823533B2 (en) 2005-06-30 2010-11-02 Advanced Cardiovascular Systems, Inc. Stent fixture and method for reducing coating defects
US7842083B2 (en) 2001-08-20 2010-11-30 Innovational Holdings, Llc. Expandable medical device with improved spatial distribution
WO2010140869A2 (en) * 2009-06-05 2010-12-09 Iljin Copper Foil Co., Ltd. Complex, multilayer using the same, and device coated with the multilayer
US7850726B2 (en) 2007-12-20 2010-12-14 Abbott Laboratories Vascular Enterprises Limited Endoprosthesis having struts linked by foot extensions
WO2011003095A1 (en) 2009-07-02 2011-01-06 Tryton Medical, Inc. Ostium support for treating vascular bifurcations
US7867547B2 (en) 2005-12-19 2011-01-11 Advanced Cardiovascular Systems, Inc. Selectively coating luminal surfaces of stents
US7875677B2 (en) 2001-04-20 2011-01-25 The University Of British Columbia Micellar drug delivery systems for hydrophobic drugs
US7887578B2 (en) * 1998-09-05 2011-02-15 Abbott Laboratories Vascular Enterprises Limited Stent having an expandable web structure
US7892592B1 (en) 2004-11-30 2011-02-22 Advanced Cardiovascular Systems, Inc. Coating abluminal surfaces of stents and other implantable medical devices
US7919075B1 (en) 2002-03-20 2011-04-05 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices
EP2308861A1 (en) 2002-03-08 2011-04-13 Eisai R&D Management Co., Ltd. Macrocyclic compounds useful as pharmaceuticals
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20110118703A1 (en) * 1999-01-25 2011-05-19 Herweck Steve A Expandable fluoropolymer device for delivery of therapeutic agents and method of making
WO2011061295A1 (en) 2009-11-19 2011-05-26 Blue Medical Devices Bv Narrow profile composition-releasing expandable medical balloon catheter
US7967998B2 (en) 2003-06-25 2011-06-28 Advanced Cardiocasvular Systems, Inc. Method of polishing implantable medical devices to lower thrombogenecity and increase mechanical stability
US7976915B2 (en) 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US7976891B1 (en) 2005-12-16 2011-07-12 Advanced Cardiovascular Systems, Inc. Abluminal stent coating apparatus and method of using focused acoustic energy
US20110172303A1 (en) * 2008-07-23 2011-07-14 Dana-Farber Cancer Institute, Inc. Deacetylase inhibitors and uses thereof
US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
US7985440B2 (en) 2001-06-27 2011-07-26 Advanced Cardiovascular Systems, Inc. Method of using a mandrel to coat a stent
US7985441B1 (en) 2006-05-04 2011-07-26 Yiwen Tang Purification of polymers for coating applications
US7989018B2 (en) 2001-09-17 2011-08-02 Advanced Cardiovascular Systems, Inc. Fluid treatment of a polymeric coating on an implantable medical device
US20110190864A1 (en) * 2010-02-02 2011-08-04 Micell Technologies, Inc. Stent and stent delivery system with improved deliverability
US8003156B2 (en) 2006-05-04 2011-08-23 Advanced Cardiovascular Systems, Inc. Rotatable support elements for stents
US8002823B2 (en) 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8007775B2 (en) 2004-12-30 2011-08-30 Advanced Cardiovascular Systems, Inc. Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same
US20110210121A1 (en) * 2007-02-13 2011-09-01 Gateway Plastics, Inc. Container system
US8017237B2 (en) 2006-06-23 2011-09-13 Abbott Cardiovascular Systems, Inc. Nanoshells on polymers
US8017140B2 (en) 2004-06-29 2011-09-13 Advanced Cardiovascular System, Inc. Drug-delivery stent formulations for restenosis and vulnerable plaque
US8016874B2 (en) 2007-05-23 2011-09-13 Abbott Laboratories Vascular Enterprises Limited Flexible stent with elevated scaffolding properties
US8021676B2 (en) 2005-07-08 2011-09-20 Advanced Cardiovascular Systems, Inc. Functionalized chemically inert polymers for coatings
WO2011119883A1 (en) 2010-03-24 2011-09-29 Advanced Bifurcation Systems, Inc. Stent alignment during treatment of a bifurcation
US8029816B2 (en) 2006-06-09 2011-10-04 Abbott Cardiovascular Systems Inc. Medical device coated with a coating containing elastin pentapeptide VGVPG
US8029554B2 (en) 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US8048448B2 (en) 2006-06-15 2011-11-01 Abbott Cardiovascular Systems Inc. Nanoshells for drug delivery
US8048441B2 (en) 2007-06-25 2011-11-01 Abbott Cardiovascular Systems, Inc. Nanobead releasing medical devices
US8052912B2 (en) 2003-12-01 2011-11-08 Advanced Cardiovascular Systems, Inc. Temperature controlled crimping
US8062350B2 (en) 2006-06-14 2011-11-22 Abbott Cardiovascular Systems Inc. RGD peptide attached to bioabsorbable stents
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US8067023B2 (en) 2002-06-21 2011-11-29 Advanced Cardiovascular Systems, Inc. Implantable medical devices incorporating plasma polymerized film layers and charged amino acids
US8067025B2 (en) 2006-02-17 2011-11-29 Advanced Cardiovascular Systems, Inc. Nitric oxide generating medical devices
US8066763B2 (en) 1998-04-11 2011-11-29 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US8109904B1 (en) 2007-06-25 2012-02-07 Abbott Cardiovascular Systems Inc. Drug delivery medical devices
US8110211B2 (en) 2004-09-22 2012-02-07 Advanced Cardiovascular Systems, Inc. Medicated coatings for implantable medical devices including polyacrylates
US8147769B1 (en) 2007-05-16 2012-04-03 Abbott Cardiovascular Systems Inc. Stent and delivery system with reduced chemical degradation
US8163717B2 (en) 2002-08-20 2012-04-24 Biosurface Engineering Technologies, Inc. Dual chain synthetic heparin-binding growth factor analogs
US8173199B2 (en) 2002-03-27 2012-05-08 Advanced Cardiovascular Systems, Inc. 40-O-(2-hydroxy)ethyl-rapamycin coated stent
US8178579B2 (en) 2001-05-09 2012-05-15 President And Fellows Of Harvard College Dioxanes and uses thereof
WO2012068109A2 (en) 2010-11-16 2012-05-24 Acetylon Pharmaceuticals Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US8192752B2 (en) 2003-11-21 2012-06-05 Advanced Cardiovascular Systems, Inc. Coatings for implantable devices including biologically erodable polyesters and methods for fabricating the same
US8197881B2 (en) 2003-09-22 2012-06-12 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
US8197879B2 (en) 2003-09-30 2012-06-12 Advanced Cardiovascular Systems, Inc. Method for selectively coating surfaces of a stent
EP2462903A1 (en) 2004-10-13 2012-06-13 Tryton Medical, Inc. Stepped balloon catheter and prosthesis for treating vascular bifurcations
US8211167B2 (en) 1999-12-06 2012-07-03 Boston Scientific Scimed, Inc. Method of using a catheter with attached flexible side sheath
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8221495B2 (en) 2002-11-07 2012-07-17 Abbott Laboratories Integration of therapeutic agent into a bioerodible medical device
US8221822B2 (en) 2007-07-31 2012-07-17 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
WO2012109365A1 (en) 2011-02-08 2012-08-16 Advanced Bifurcation Systems, Inc. System and methods for treating a bifurcation with a fully crimped stent
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
US8293890B2 (en) 2004-04-30 2012-10-23 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers
US8298280B2 (en) 2003-08-21 2012-10-30 Boston Scientific Scimed, Inc. Stent with protruding branch portion for bifurcated vessels
US8303651B1 (en) 2001-09-07 2012-11-06 Advanced Cardiovascular Systems, Inc. Polymeric coating for reducing the rate of release of a therapeutic substance from a stent
US8304012B2 (en) 2006-05-04 2012-11-06 Advanced Cardiovascular Systems, Inc. Method for drying a stent
US8353949B2 (en) 2006-09-14 2013-01-15 Boston Scientific Scimed, Inc. Medical devices with drug-eluting coating
US8357391B2 (en) 2004-07-30 2013-01-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages
US8377108B2 (en) 2008-06-02 2013-02-19 Boston Scientific Scimed, Inc. Staggered two balloon bifurcation catheter assembly and methods
US8389041B2 (en) 2010-06-17 2013-03-05 Abbott Cardiovascular Systems, Inc. Systems and methods for rotating and coating an implantable device
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8435550B2 (en) 2002-12-16 2013-05-07 Abbot Cardiovascular Systems Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
US8449901B2 (en) 2003-03-28 2013-05-28 Innovational Holdings, Llc Implantable medical device with beneficial agent concentration gradient
US8449603B2 (en) 2008-06-18 2013-05-28 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8506617B1 (en) 2002-06-21 2013-08-13 Advanced Cardiovascular Systems, Inc. Micronized peptide coated stent
US8551512B2 (en) 2004-03-22 2013-10-08 Advanced Cardiovascular Systems, Inc. Polyethylene glycol/poly(butylene terephthalate) copolymer coated devices including EVEROLIMUS
US8568764B2 (en) 2006-05-31 2013-10-29 Advanced Cardiovascular Systems, Inc. Methods of forming coating layers for medical devices utilizing flash vaporization
US8574615B2 (en) 2006-03-24 2013-11-05 Boston Scientific Scimed, Inc. Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8597673B2 (en) 2006-12-13 2013-12-03 Advanced Cardiovascular Systems, Inc. Coating of fast absorption or dissolution
US8603634B2 (en) 2004-10-27 2013-12-10 Abbott Cardiovascular Systems Inc. End-capped poly(ester amide) copolymers
US8603530B2 (en) 2006-06-14 2013-12-10 Abbott Cardiovascular Systems Inc. Nanoshell therapy
US8609123B2 (en) 2004-11-29 2013-12-17 Advanced Cardiovascular Systems, Inc. Derivatized poly(ester amide) as a biobeneficial coating
US8617231B2 (en) 2001-05-18 2013-12-31 Boston Scientific Scimed, Inc. Dual guidewire exchange catheter system
WO2014047328A2 (en) 2012-09-19 2014-03-27 Faller Douglas V Pkc delta inhibitors for use as therapeutics
US8685431B2 (en) 2004-03-16 2014-04-01 Advanced Cardiovascular Systems, Inc. Biologically absorbable coatings for implantable devices based on copolymers having ester bonds and methods for fabricating the same
US8685430B1 (en) 2006-07-14 2014-04-01 Abbott Cardiovascular Systems Inc. Tailored aliphatic polyesters for stent coatings
US8703167B2 (en) 2006-06-05 2014-04-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug
US8703169B1 (en) 2006-08-15 2014-04-22 Abbott Cardiovascular Systems Inc. Implantable device having a coating comprising carrageenan and a biostable polymer
US8702779B2 (en) 2003-11-12 2014-04-22 Boston Scientific Scimed, Inc. Catheter balloon systems and methods
US8716344B2 (en) 2009-08-11 2014-05-06 President And Fellows Of Harvard College Class- and isoform-specific HDAC inhibitors and uses thereof
US8741378B1 (en) 2001-06-27 2014-06-03 Advanced Cardiovascular Systems, Inc. Methods of coating an implantable device
US8747456B2 (en) 2007-12-31 2014-06-10 Boston Scientific Scimed, Inc. Bifurcation stent delivery system and methods
US8758429B2 (en) 2005-07-15 2014-06-24 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology
WO2013156871A3 (en) * 2012-04-17 2014-06-26 University College Dublin, National University Of Ireland, Dublin Thromboxane receptor antagonists
US8771343B2 (en) 2006-06-29 2014-07-08 Boston Scientific Scimed, Inc. Medical devices with selective titanium oxide coatings
US8771342B2 (en) 1996-11-04 2014-07-08 Boston Scientific Scimed, Inc. Methods for deploying stents in bifurcations
US8778014B1 (en) 2004-03-31 2014-07-15 Advanced Cardiovascular Systems, Inc. Coatings for preventing balloon damage to polymer coated stents
US8778375B2 (en) 2005-04-29 2014-07-15 Advanced Cardiovascular Systems, Inc. Amorphous poly(D,L-lactide) coating
US8795762B2 (en) 2010-03-26 2014-08-05 Battelle Memorial Institute System and method for enhanced electrostatic deposition and surface coatings
US8814820B2 (en) * 2000-04-14 2014-08-26 Glaukos Corporation Ocular implant with therapeutic agent and methods thereof
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
US8821561B2 (en) 2006-02-22 2014-09-02 Boston Scientific Scimed, Inc. Marker arrangement for bifurcation catheter
US8827954B2 (en) 2008-06-05 2014-09-09 Boston Scientific Scimed, Inc. Deflatable bifurcated device
US8834913B2 (en) 2008-12-26 2014-09-16 Battelle Memorial Institute Medical implants and methods of making medical implants
US8900292B2 (en) 2007-08-03 2014-12-02 Boston Scientific Scimed, Inc. Coating for medical device having increased surface area
US8900651B2 (en) 2007-05-25 2014-12-02 Micell Technologies, Inc. Polymer films for medical device coating
US8920491B2 (en) 2008-04-22 2014-12-30 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
US8920488B2 (en) 2007-12-20 2014-12-30 Abbott Laboratories Vascular Enterprises Limited Endoprosthesis having a stable architecture
US8932346B2 (en) 2008-04-24 2015-01-13 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
US8936567B2 (en) 2007-11-14 2015-01-20 Boston Scientific Scimed, Inc. Balloon bifurcated lumen treatment
US9028859B2 (en) 2006-07-07 2015-05-12 Advanced Cardiovascular Systems, Inc. Phase-separated block copolymer coatings for implantable medical devices
US9056155B1 (en) 2007-05-29 2015-06-16 Abbott Cardiovascular Systems Inc. Coatings having an elastic primer layer
US9066782B2 (en) 2000-04-14 2015-06-30 Dose Medical Corporation Ocular implant with therapeutic agents and methods thereof
US9114198B2 (en) 2003-11-19 2015-08-25 Advanced Cardiovascular Systems, Inc. Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same
USRE45744E1 (en) 2003-12-01 2015-10-13 Abbott Cardiovascular Systems Inc. Temperature controlled crimping
US9284409B2 (en) 2007-07-19 2016-03-15 Boston Scientific Scimed, Inc. Endoprosthesis having a non-fouling surface
US20160102051A1 (en) * 2012-04-17 2016-04-14 University College Dublin, National University Of Ireland, Dublin Methods and compounds for treating proliferative disorders and viral infections
US9339592B2 (en) 2004-12-22 2016-05-17 Abbott Cardiovascular Systems Inc. Polymers of fluorinated monomers and hydrocarbon monomers
US9364498B2 (en) 2004-06-18 2016-06-14 Abbott Cardiovascular Systems Inc. Heparin prodrugs and drug delivery stents formed therefrom
WO2016105518A1 (en) 2014-12-23 2016-06-30 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
US9433516B2 (en) 2007-04-17 2016-09-06 Micell Technologies, Inc. Stents having controlled elution
US9486431B2 (en) 2008-07-17 2016-11-08 Micell Technologies, Inc. Drug delivery medical device
EP3091004A1 (en) 2010-01-22 2016-11-09 Acetylon Pharmaceuticals, Inc. Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof
US9510856B2 (en) 2008-07-17 2016-12-06 Micell Technologies, Inc. Drug delivery medical device
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US9539593B2 (en) 2006-10-23 2017-01-10 Micell Technologies, Inc. Holder for electrically charging a substrate during coating
US9561309B2 (en) 2004-05-27 2017-02-07 Advanced Cardiovascular Systems, Inc. Antifouling heparin coatings
US9561351B2 (en) 2006-05-31 2017-02-07 Advanced Cardiovascular Systems, Inc. Drug delivery spiral coil construct
WO2017024317A2 (en) 2015-08-06 2017-02-09 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
US9580558B2 (en) 2004-07-30 2017-02-28 Abbott Cardiovascular Systems Inc. Polymers containing siloxane monomers
US9670258B2 (en) 2004-02-20 2017-06-06 Ferring B.V. Positive modulator of bone morphogenic protein-2
US9730638B2 (en) 2013-03-13 2017-08-15 Glaukos Corporation Intraocular physiological sensor
US9789233B2 (en) 2008-04-17 2017-10-17 Micell Technologies, Inc. Stents having bioabsorbable layers
US9932304B2 (en) 2016-06-13 2018-04-03 University College Dublin, National University Of Ireland, Dublin Thromboxane receptor antagonists

Citations (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3663288A (en) 1969-09-04 1972-05-16 American Cyanamid Co Physiologically acceptible elastomeric article
US3779792A (en) 1970-03-13 1973-12-18 Ceskoslovenska Akademie Ved Method of protecting glass against fogging
US4047957A (en) 1975-02-10 1977-09-13 Agfa-Gevaert N.V. Process of hardening protein-containing photographic layers with a mixture of a carboxyl group-activating, low molecular weight compound and a carboxyl group-activating polymer
US4100309A (en) 1977-08-08 1978-07-11 Biosearch Medical Products, Inc. Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same
US4119094A (en) 1977-08-08 1978-10-10 Biosearch Medical Products Inc. Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same
US4263188A (en) 1979-05-23 1981-04-21 Verbatim Corporation Aqueous coating composition and method
US4306998A (en) 1979-07-26 1981-12-22 Bayer Aktiengesellschaft Process for the preparation of stable aqueous dispersions of oligourethanes or polyurethanes and their use as coating compounds for flexible or rigid substrates
US4373009A (en) 1981-05-18 1983-02-08 International Silicone Corporation Method of forming a hydrophilic coating on a substrate
US4387024A (en) 1979-12-13 1983-06-07 Toray Industries, Inc. High performance semipermeable composite membrane and process for producing the same
US4391797A (en) 1977-01-05 1983-07-05 The Children's Hospital Medical Center Systems for the controlled release of macromolecules
US4459317A (en) 1982-04-22 1984-07-10 Astra Meditec Aktiebolag Process for the preparation of a hydrophilic coating
US4487808A (en) 1982-04-22 1984-12-11 Astra Meditec Aktiebolag Medical article having a hydrophilic coating
US4536179A (en) 1982-09-24 1985-08-20 University Of Minnesota Implantable catheters with non-adherent contacting polymer surfaces
US4548844A (en) 1982-09-03 1985-10-22 Howard I. Podell Flexible coated article and method of making same
US4642267A (en) 1985-05-06 1987-02-10 Hydromer, Inc. Hydrophilic polymer blend
US4666437A (en) 1982-04-22 1987-05-19 Astra Meditec Aktiebolag Hydrophilic coating
US4675361A (en) 1980-02-29 1987-06-23 Thoratec Laboratories Corp. Polymer systems suitable for blood-contacting surfaces of a biomedical device, and methods for forming
US4692352A (en) 1986-04-29 1987-09-08 The Kendall Company Method of making an adhesive tape
US4705709A (en) 1985-09-25 1987-11-10 Sherwood Medical Company Lubricant composition, method of coating and a coated intubation device
US4721117A (en) 1986-04-25 1988-01-26 Advanced Cardiovascular Systems, Inc. Torsionally stabilized guide wire with outer jacket
US4748986A (en) 1985-11-26 1988-06-07 Advanced Cardiovascular Systems, Inc. Floppy guide wire with opaque tip
US4768507A (en) 1986-02-24 1988-09-06 Medinnovations, Inc. Intravascular stent and percutaneous insertion catheter system for the dilation of an arterial stenosis and the prevention of arterial restenosis
US4770664A (en) 1984-02-03 1988-09-13 Mendinvent S.A. Multilayered prosthesis material and a method of producing same
US4833014A (en) 1986-04-21 1989-05-23 Aligena Ag Composite membranes useful for the separation of organic compounds of low molecular weight from aqueous inorganic salts containing solutions
US4841976A (en) 1987-12-17 1989-06-27 Schneider-Shiley (Usa) Inc. Steerable catheter guide
US4867173A (en) 1986-06-30 1989-09-19 Meadox Surgimed A/S Steerable guidewire
US4876126A (en) 1984-06-04 1989-10-24 Terumo Kabushiki Kaisha Medical instrument and method for making
US4884579A (en) 1988-04-18 1989-12-05 Target Therapeutics Catheter guide wire
US4923464A (en) 1985-09-03 1990-05-08 Becton, Dickinson And Company Percutaneously deliverable intravascular reconstruction prosthesis
US4925698A (en) 1988-02-23 1990-05-15 Tekmat Corporation Surface modification of polymeric materials
US4943460A (en) 1988-02-19 1990-07-24 Snyder Laboratories, Inc. Process for coating polymer surfaces and coated products produced using such process
US4959074A (en) 1984-08-23 1990-09-25 Gergory Halpern Method of hydrophilic coating of plastics
US4964409A (en) 1989-05-11 1990-10-23 Advanced Cardiovascular Systems, Inc. Flexible hollow guiding member with means for fluid communication therethrough
US4969890A (en) 1987-07-10 1990-11-13 Nippon Zeon Co., Ltd. Catheter
US4980231A (en) 1988-02-19 1990-12-25 Snyder Laboratories, Inc. Process for coating polymer surfaces and coated products produced using such process
US4994071A (en) 1989-05-22 1991-02-19 Cordis Corporation Bifurcating stent apparatus and method
US5002582A (en) 1982-09-29 1991-03-26 Bio-Metric Systems, Inc. Preparation of polymeric surfaces via covalently attaching polymers
US5007928A (en) 1988-05-31 1991-04-16 Canon Kabushiki Kaisha Intraocular implant having coating layer
US5008363A (en) 1990-03-23 1991-04-16 Union Carbide Chemicals And Plastics Technology Corporation Low temperature active aliphatic aromatic polycarbodiimides
US5019096A (en) 1988-02-11 1991-05-28 Trustees Of Columbia University In The City Of New York Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same
US5026607A (en) 1989-06-23 1991-06-25 C. R. Bard, Inc. Medical apparatus having protective, lubricious coating
US5037677A (en) 1984-08-23 1991-08-06 Gregory Halpern Method of interlaminar grafting of coatings
US5037656A (en) 1986-12-04 1991-08-06 Millipore Corporation Porous membrane having hydrophilic and cell growth promotions surface and process
US5040543A (en) 1990-07-25 1991-08-20 C. R. Bard, Inc. Movable core guidewire
US5049403A (en) 1989-10-12 1991-09-17 Horsk Hydro A.S. Process for the preparation of surface modified solid substrates
US5057371A (en) 1985-06-14 1991-10-15 Minnesota Mining And Manufacturing Company Aziridine-treated articles
US5066705A (en) 1990-01-17 1991-11-19 The Glidden Company Ambient cure protective coatings for plastic substrates
US5067489A (en) 1988-08-16 1991-11-26 Flexmedics Corporation Flexible guide with safety tip
US5069226A (en) 1989-04-28 1991-12-03 Tokin Corporation Catheter guidewire with pseudo elastic shape memory alloy
US5069217A (en) 1990-07-09 1991-12-03 Lake Region Manufacturing Co., Inc. Steerable guide wire
US5079093A (en) 1988-08-09 1992-01-07 Toray Industries, Inc. Easily-slippery medical materials and a method for preparation thereof
US5080683A (en) 1987-12-09 1992-01-14 Ceskoslovenska Akademie Ved Method for the formation of thin hydrophilic layers on the surface of objects made from non-hydrophilic methacrylate and acrylate polymers
US5080924A (en) 1989-04-24 1992-01-14 Drexel University Method of making biocompatible, surface modified materials
US5084315A (en) 1990-02-01 1992-01-28 Becton, Dickinson And Company Lubricious coatings, medical articles containing same and method for their preparation
US5091205A (en) 1989-01-17 1992-02-25 Union Carbide Chemicals & Plastics Technology Corporation Hydrophilic lubricious coatings
US5092885A (en) 1987-02-12 1992-03-03 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Peptides with laminin activity
US5102401A (en) 1990-08-22 1992-04-07 Becton, Dickinson And Company Expandable catheter having hydrophobic surface
US5102402A (en) 1991-01-04 1992-04-07 Medtronic, Inc. Releasable coatings on balloon catheters
US5102417A (en) 1985-11-07 1992-04-07 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US5105010A (en) 1991-06-13 1992-04-14 Ppg Industries, Inc. Carbodiimide compounds, polymers containing same and coating compositions containing said polymers
US5107852A (en) 1990-04-02 1992-04-28 W. L. Gore & Associates, Inc. Catheter guidewire device having a covering of fluoropolymer tape
US5128170A (en) 1989-05-11 1992-07-07 Kanegafunchi Kagaku Kogyo Kabushiki Kaisha Method for manufacturing medical device having a highly biocompatible surface
US5129890A (en) 1989-06-29 1992-07-14 Cook Incorporated Hydrophilically coated flexible wire guide
US5160790A (en) 1990-11-01 1992-11-03 C. R. Bard, Inc. Lubricious hydrogel coatings
US5211183A (en) 1987-05-13 1993-05-18 Wilson Bruce C Steerable memory alloy guide wires
US5213111A (en) 1991-07-10 1993-05-25 Cook Incorporated Composite wire guide construction
US5217026A (en) 1992-04-06 1993-06-08 Kingston Technologies, Inc. Guidewires with lubricious surface and method of their production
US5222971A (en) 1990-10-09 1993-06-29 Scimed Life Systems, Inc. Temporary stent and methods for use and manufacture
US5240994A (en) 1990-10-22 1993-08-31 Berol Nobel Ab Solid surface coated with a hydrophilic biopolymer-repellent outer layer and method of making such a surface
US5241970A (en) 1991-05-17 1993-09-07 Wilson-Cook Medical, Inc. Papillotome/sphincterotome procedures and a wire guide specially
US5243996A (en) 1992-01-03 1993-09-14 Cook, Incorporated Small-diameter superelastic wire guide
US5250613A (en) 1990-10-22 1993-10-05 Berol Nobel Ab Solid surface coated with a hydrophilic outer layer with covalently bonded biopolymers, a method of making such a surface, and a conjugate therefor
US5266359A (en) 1991-01-14 1993-11-30 Becton, Dickinson And Company Lubricative coating composition, article and assembly containing same and method thereof
US5272012A (en) * 1989-06-23 1993-12-21 C. R. Bard, Inc. Medical apparatus having protective, lubricious coating
US5275173A (en) 1991-08-26 1994-01-04 Target Therapeutics, Inc. Extendable guidewire assembly
US5282823A (en) 1992-03-19 1994-02-01 Medtronic, Inc. Intravascular radially expandable stent
US5304140A (en) 1987-08-28 1994-04-19 Terumo Kabushiki Kaisha Catheter for introduction into blood vessel
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5324261A (en) 1991-01-04 1994-06-28 Medtronic, Inc. Drug delivery balloon catheter with line of weakness
US5380299A (en) 1993-08-30 1995-01-10 Med Institute, Inc. Thrombolytic treated intravascular medical device
US5383928A (en) 1992-06-10 1995-01-24 Emory University Stent sheath for local drug delivery
US5419760A (en) 1993-01-08 1995-05-30 Pdt Systems, Inc. Medicament dispensing stent for prevention of restenosis of a blood vessel
US5423885A (en) 1992-01-31 1995-06-13 Advanced Cardiovascular Systems, Inc. Stent capable of attachment within a body lumen
US5443458A (en) 1992-12-22 1995-08-22 Advanced Cardiovascular Systems, Inc. Multilayered biodegradable stent and method of manufacture
US5447724A (en) 1990-05-17 1995-09-05 Harbor Medical Devices, Inc. Medical device polymer
US5449382A (en) 1992-11-04 1995-09-12 Dayton; Michael P. Minimally invasive bioactivated endoprosthesis for vessel repair
US5449372A (en) 1990-10-09 1995-09-12 Scimed Lifesystems, Inc. Temporary stent and methods for use and manufacture
US5464650A (en) 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
US5512055A (en) 1991-02-27 1996-04-30 Leonard Bloom Anti-infective and anti-inflammatory releasing systems for medical devices
US5514154A (en) 1991-10-28 1996-05-07 Advanced Cardiovascular Systems, Inc. Expandable stents
US5527337A (en) 1987-06-25 1996-06-18 Duke University Bioabsorbable stent and method of making the same
US5545208A (en) 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5562922A (en) 1993-03-18 1996-10-08 Cedars-Sinai Medical Center Drug incorporating and release polymeric coating for bioprosthesis
US5576072A (en) 1995-02-01 1996-11-19 Schneider (Usa), Inc. Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with at least one other, dissimilar polymer hydrogel
US5578075A (en) 1992-11-04 1996-11-26 Michael Peck Dayton Minimally invasive bioactivated endoprosthesis for vessel repair
US5591227A (en) 1992-03-19 1997-01-07 Medtronic, Inc. Drug eluting stent
US5605696A (en) 1995-03-30 1997-02-25 Advanced Cardiovascular Systems, Inc. Drug loaded polymeric material and method of manufacture
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
US5616608A (en) 1993-07-29 1997-04-01 The United States Of America As Represented By The Department Of Health And Human Services Method of treating atherosclerosis or restenosis using microtubule stabilizing agent
US5620738A (en) 1995-06-07 1997-04-15 Union Carbide Chemicals & Plastics Technology Corporation Non-reactive lubicious coating process
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5637113A (en) 1994-12-13 1997-06-10 Advanced Cardiovascular Systems, Inc. Polymer film for wrapping a stent structure
US5670507A (en) * 1995-01-27 1997-09-23 Cell Therapeutics, Inc. Method for reversing multiple drug resistant phenotype
US5674192A (en) 1990-12-28 1997-10-07 Boston Scientific Corporation Drug delivery
US5674241A (en) 1995-02-22 1997-10-07 Menlo Care, Inc. Covered expanding mesh stent
US5674242A (en) 1995-06-06 1997-10-07 Quanam Medical Corporation Endoprosthetic device with therapeutic compound
US5702754A (en) 1995-02-22 1997-12-30 Meadox Medicals, Inc. Method of providing a substrate with a hydrophilic coating and substrates, particularly medical devices, provided with such coatings
US5709874A (en) 1993-04-14 1998-01-20 Emory University Device for local drug delivery and methods for using the same
US5712326A (en) 1992-12-23 1998-01-27 Biocompatibles Limited Polymeric blends with zwitterionic groups
US5716981A (en) 1993-07-19 1998-02-10 Angiogenesis Technologies, Inc. Anti-angiogenic compositions and methods of use
US5733925A (en) 1993-01-28 1998-03-31 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
EP0832618A1 (en) * 1996-09-25 1998-04-01 Terumo Kabushiki Kaisha Stent for dilating a stenotic lesion of a blood vessel
US5739237A (en) 1994-01-28 1998-04-14 Biocompatibles Limited Materials and their use in the preparation of biocompatible surfaces
US5755769A (en) 1992-03-12 1998-05-26 Laboratoire Perouse Implant Expansible endoprosthesis for a human or animal tubular organ, and fitting tool for use thereof
US5779732A (en) 1997-03-31 1998-07-14 Medtronic, Inc. Method and apparatus for implanting a film with an exandable stent

Patent Citations (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3663288A (en) 1969-09-04 1972-05-16 American Cyanamid Co Physiologically acceptible elastomeric article
US3779792A (en) 1970-03-13 1973-12-18 Ceskoslovenska Akademie Ved Method of protecting glass against fogging
US4047957A (en) 1975-02-10 1977-09-13 Agfa-Gevaert N.V. Process of hardening protein-containing photographic layers with a mixture of a carboxyl group-activating, low molecular weight compound and a carboxyl group-activating polymer
US4391797A (en) 1977-01-05 1983-07-05 The Children's Hospital Medical Center Systems for the controlled release of macromolecules
US4100309A (en) 1977-08-08 1978-07-11 Biosearch Medical Products, Inc. Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same
US4119094A (en) 1977-08-08 1978-10-10 Biosearch Medical Products Inc. Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same
US4263188A (en) 1979-05-23 1981-04-21 Verbatim Corporation Aqueous coating composition and method
US4306998A (en) 1979-07-26 1981-12-22 Bayer Aktiengesellschaft Process for the preparation of stable aqueous dispersions of oligourethanes or polyurethanes and their use as coating compounds for flexible or rigid substrates
US4387024A (en) 1979-12-13 1983-06-07 Toray Industries, Inc. High performance semipermeable composite membrane and process for producing the same
US4675361A (en) 1980-02-29 1987-06-23 Thoratec Laboratories Corp. Polymer systems suitable for blood-contacting surfaces of a biomedical device, and methods for forming
US4373009A (en) 1981-05-18 1983-02-08 International Silicone Corporation Method of forming a hydrophilic coating on a substrate
US4459317A (en) 1982-04-22 1984-07-10 Astra Meditec Aktiebolag Process for the preparation of a hydrophilic coating
US4487808A (en) 1982-04-22 1984-12-11 Astra Meditec Aktiebolag Medical article having a hydrophilic coating
US4666437A (en) 1982-04-22 1987-05-19 Astra Meditec Aktiebolag Hydrophilic coating
US4548844A (en) 1982-09-03 1985-10-22 Howard I. Podell Flexible coated article and method of making same
US4536179A (en) 1982-09-24 1985-08-20 University Of Minnesota Implantable catheters with non-adherent contacting polymer surfaces
US5002582A (en) 1982-09-29 1991-03-26 Bio-Metric Systems, Inc. Preparation of polymeric surfaces via covalently attaching polymers
US4770664A (en) 1984-02-03 1988-09-13 Mendinvent S.A. Multilayered prosthesis material and a method of producing same
US4876126A (en) 1984-06-04 1989-10-24 Terumo Kabushiki Kaisha Medical instrument and method for making
US5037677A (en) 1984-08-23 1991-08-06 Gregory Halpern Method of interlaminar grafting of coatings
US4959074A (en) 1984-08-23 1990-09-25 Gergory Halpern Method of hydrophilic coating of plastics
US4642267A (en) 1985-05-06 1987-02-10 Hydromer, Inc. Hydrophilic polymer blend
US5057371A (en) 1985-06-14 1991-10-15 Minnesota Mining And Manufacturing Company Aziridine-treated articles
US4923464A (en) 1985-09-03 1990-05-08 Becton, Dickinson And Company Percutaneously deliverable intravascular reconstruction prosthesis
US4705709A (en) 1985-09-25 1987-11-10 Sherwood Medical Company Lubricant composition, method of coating and a coated intubation device
US5102417A (en) 1985-11-07 1992-04-07 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4748986A (en) 1985-11-26 1988-06-07 Advanced Cardiovascular Systems, Inc. Floppy guide wire with opaque tip
US4768507A (en) 1986-02-24 1988-09-06 Medinnovations, Inc. Intravascular stent and percutaneous insertion catheter system for the dilation of an arterial stenosis and the prevention of arterial restenosis
US4833014A (en) 1986-04-21 1989-05-23 Aligena Ag Composite membranes useful for the separation of organic compounds of low molecular weight from aqueous inorganic salts containing solutions
US4721117A (en) 1986-04-25 1988-01-26 Advanced Cardiovascular Systems, Inc. Torsionally stabilized guide wire with outer jacket
US4692352A (en) 1986-04-29 1987-09-08 The Kendall Company Method of making an adhesive tape
US4867173A (en) 1986-06-30 1989-09-19 Meadox Surgimed A/S Steerable guidewire
US5037656A (en) 1986-12-04 1991-08-06 Millipore Corporation Porous membrane having hydrophilic and cell growth promotions surface and process
US5092885A (en) 1987-02-12 1992-03-03 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Peptides with laminin activity
US5211183A (en) 1987-05-13 1993-05-18 Wilson Bruce C Steerable memory alloy guide wires
US5527337A (en) 1987-06-25 1996-06-18 Duke University Bioabsorbable stent and method of making the same
US4969890A (en) 1987-07-10 1990-11-13 Nippon Zeon Co., Ltd. Catheter
US5304140A (en) 1987-08-28 1994-04-19 Terumo Kabushiki Kaisha Catheter for introduction into blood vessel
US5080683A (en) 1987-12-09 1992-01-14 Ceskoslovenska Akademie Ved Method for the formation of thin hydrophilic layers on the surface of objects made from non-hydrophilic methacrylate and acrylate polymers
US4841976A (en) 1987-12-17 1989-06-27 Schneider-Shiley (Usa) Inc. Steerable catheter guide
US5019096A (en) 1988-02-11 1991-05-28 Trustees Of Columbia University In The City Of New York Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same
US4980231A (en) 1988-02-19 1990-12-25 Snyder Laboratories, Inc. Process for coating polymer surfaces and coated products produced using such process
US4943460A (en) 1988-02-19 1990-07-24 Snyder Laboratories, Inc. Process for coating polymer surfaces and coated products produced using such process
US4925698A (en) 1988-02-23 1990-05-15 Tekmat Corporation Surface modification of polymeric materials
US4884579A (en) 1988-04-18 1989-12-05 Target Therapeutics Catheter guide wire
US5007928A (en) 1988-05-31 1991-04-16 Canon Kabushiki Kaisha Intraocular implant having coating layer
US5079093A (en) 1988-08-09 1992-01-07 Toray Industries, Inc. Easily-slippery medical materials and a method for preparation thereof
US5067489A (en) 1988-08-16 1991-11-26 Flexmedics Corporation Flexible guide with safety tip
US5091205A (en) 1989-01-17 1992-02-25 Union Carbide Chemicals & Plastics Technology Corporation Hydrophilic lubricious coatings
US5080924A (en) 1989-04-24 1992-01-14 Drexel University Method of making biocompatible, surface modified materials
US5069226A (en) 1989-04-28 1991-12-03 Tokin Corporation Catheter guidewire with pseudo elastic shape memory alloy
US4964409A (en) 1989-05-11 1990-10-23 Advanced Cardiovascular Systems, Inc. Flexible hollow guiding member with means for fluid communication therethrough
US5128170A (en) 1989-05-11 1992-07-07 Kanegafunchi Kagaku Kogyo Kabushiki Kaisha Method for manufacturing medical device having a highly biocompatible surface
US4994071A (en) 1989-05-22 1991-02-19 Cordis Corporation Bifurcating stent apparatus and method
US5272012A (en) * 1989-06-23 1993-12-21 C. R. Bard, Inc. Medical apparatus having protective, lubricious coating
US5026607A (en) 1989-06-23 1991-06-25 C. R. Bard, Inc. Medical apparatus having protective, lubricious coating
US5129890A (en) 1989-06-29 1992-07-14 Cook Incorporated Hydrophilically coated flexible wire guide
US5049403A (en) 1989-10-12 1991-09-17 Horsk Hydro A.S. Process for the preparation of surface modified solid substrates
US5066705A (en) 1990-01-17 1991-11-19 The Glidden Company Ambient cure protective coatings for plastic substrates
US5084315A (en) 1990-02-01 1992-01-28 Becton, Dickinson And Company Lubricious coatings, medical articles containing same and method for their preparation
US5545208A (en) 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5008363A (en) 1990-03-23 1991-04-16 Union Carbide Chemicals And Plastics Technology Corporation Low temperature active aliphatic aromatic polycarbodiimides
US5107852A (en) 1990-04-02 1992-04-28 W. L. Gore & Associates, Inc. Catheter guidewire device having a covering of fluoropolymer tape
US5447724A (en) 1990-05-17 1995-09-05 Harbor Medical Devices, Inc. Medical device polymer
US5569463A (en) 1990-05-17 1996-10-29 Harbor Medical Devices, Inc. Medical device polymer
US5069217A (en) 1990-07-09 1991-12-03 Lake Region Manufacturing Co., Inc. Steerable guide wire
US5040543A (en) 1990-07-25 1991-08-20 C. R. Bard, Inc. Movable core guidewire
US5102401A (en) 1990-08-22 1992-04-07 Becton, Dickinson And Company Expandable catheter having hydrophobic surface
US5222971A (en) 1990-10-09 1993-06-29 Scimed Life Systems, Inc. Temporary stent and methods for use and manufacture
US5449372A (en) 1990-10-09 1995-09-12 Scimed Lifesystems, Inc. Temporary stent and methods for use and manufacture
US5240994A (en) 1990-10-22 1993-08-31 Berol Nobel Ab Solid surface coated with a hydrophilic biopolymer-repellent outer layer and method of making such a surface
US5250613A (en) 1990-10-22 1993-10-05 Berol Nobel Ab Solid surface coated with a hydrophilic outer layer with covalently bonded biopolymers, a method of making such a surface, and a conjugate therefor
US5290585A (en) 1990-11-01 1994-03-01 C. R. Bard, Inc. Lubricious hydrogel coatings
US5160790A (en) 1990-11-01 1992-11-03 C. R. Bard, Inc. Lubricious hydrogel coatings
US5674192A (en) 1990-12-28 1997-10-07 Boston Scientific Corporation Drug delivery
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5370614A (en) 1991-01-04 1994-12-06 Medtronic, Inc. Method for making a drug delivery balloon catheter
US5102402A (en) 1991-01-04 1992-04-07 Medtronic, Inc. Releasable coatings on balloon catheters
US5324261A (en) 1991-01-04 1994-06-28 Medtronic, Inc. Drug delivery balloon catheter with line of weakness
US5266359A (en) 1991-01-14 1993-11-30 Becton, Dickinson And Company Lubricative coating composition, article and assembly containing same and method thereof
US5512055A (en) 1991-02-27 1996-04-30 Leonard Bloom Anti-infective and anti-inflammatory releasing systems for medical devices
US5241970A (en) 1991-05-17 1993-09-07 Wilson-Cook Medical, Inc. Papillotome/sphincterotome procedures and a wire guide specially
US5105010A (en) 1991-06-13 1992-04-14 Ppg Industries, Inc. Carbodiimide compounds, polymers containing same and coating compositions containing said polymers
US5213111A (en) 1991-07-10 1993-05-25 Cook Incorporated Composite wire guide construction
US5275173A (en) 1991-08-26 1994-01-04 Target Therapeutics, Inc. Extendable guidewire assembly
US5514154A (en) 1991-10-28 1996-05-07 Advanced Cardiovascular Systems, Inc. Expandable stents
US5243996A (en) 1992-01-03 1993-09-14 Cook, Incorporated Small-diameter superelastic wire guide
US5423885A (en) 1992-01-31 1995-06-13 Advanced Cardiovascular Systems, Inc. Stent capable of attachment within a body lumen
US5755769A (en) 1992-03-12 1998-05-26 Laboratoire Perouse Implant Expansible endoprosthesis for a human or animal tubular organ, and fitting tool for use thereof
US5697967A (en) 1992-03-19 1997-12-16 Medtronic, Inc. Drug eluting stent
US5282823A (en) 1992-03-19 1994-02-01 Medtronic, Inc. Intravascular radially expandable stent
US5443496A (en) 1992-03-19 1995-08-22 Medtronic, Inc. Intravascular radially expandable stent
US5591227A (en) 1992-03-19 1997-01-07 Medtronic, Inc. Drug eluting stent
US5217026A (en) 1992-04-06 1993-06-08 Kingston Technologies, Inc. Guidewires with lubricious surface and method of their production
US5383928A (en) 1992-06-10 1995-01-24 Emory University Stent sheath for local drug delivery
US5578075A (en) 1992-11-04 1996-11-26 Michael Peck Dayton Minimally invasive bioactivated endoprosthesis for vessel repair
US5449382A (en) 1992-11-04 1995-09-12 Dayton; Michael P. Minimally invasive bioactivated endoprosthesis for vessel repair
US5578075B1 (en) 1992-11-04 2000-02-08 Daynke Res Inc Minimally invasive bioactivated endoprosthesis for vessel repair
US5443458A (en) 1992-12-22 1995-08-22 Advanced Cardiovascular Systems, Inc. Multilayered biodegradable stent and method of manufacture
US5712326A (en) 1992-12-23 1998-01-27 Biocompatibles Limited Polymeric blends with zwitterionic groups
US5419760A (en) 1993-01-08 1995-05-30 Pdt Systems, Inc. Medicament dispensing stent for prevention of restenosis of a blood vessel
US5733925A (en) 1993-01-28 1998-03-31 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5562922A (en) 1993-03-18 1996-10-08 Cedars-Sinai Medical Center Drug incorporating and release polymeric coating for bioprosthesis
US5709874A (en) 1993-04-14 1998-01-20 Emory University Device for local drug delivery and methods for using the same
US5679400A (en) 1993-04-26 1997-10-21 Medtronic, Inc. Intravascular stent and method
US5776184A (en) 1993-04-26 1998-07-07 Medtronic, Inc. Intravasoular stent and method
US5837008A (en) 1993-04-26 1998-11-17 Medtronic, Inc. Intravascular stent and method
US5624411A (en) 1993-04-26 1997-04-29 Medtronic, Inc. Intravascular stent and method
US5464650A (en) 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
US5716981A (en) 1993-07-19 1998-02-10 Angiogenesis Technologies, Inc. Anti-angiogenic compositions and methods of use
US5616608A (en) 1993-07-29 1997-04-01 The United States Of America As Represented By The Department Of Health And Human Services Method of treating atherosclerosis or restenosis using microtubule stabilizing agent
US5380299A (en) 1993-08-30 1995-01-10 Med Institute, Inc. Thrombolytic treated intravascular medical device
US5739237A (en) 1994-01-28 1998-04-14 Biocompatibles Limited Materials and their use in the preparation of biocompatible surfaces
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5651986A (en) 1994-08-02 1997-07-29 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5637113A (en) 1994-12-13 1997-06-10 Advanced Cardiovascular Systems, Inc. Polymer film for wrapping a stent structure
US5700286A (en) 1994-12-13 1997-12-23 Advanced Cardiovascular Systems, Inc. Polymer film for wrapping a stent structure
US5670507A (en) * 1995-01-27 1997-09-23 Cell Therapeutics, Inc. Method for reversing multiple drug resistant phenotype
US5576072A (en) 1995-02-01 1996-11-19 Schneider (Usa), Inc. Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with at least one other, dissimilar polymer hydrogel
US5674241A (en) 1995-02-22 1997-10-07 Menlo Care, Inc. Covered expanding mesh stent
US5702754A (en) 1995-02-22 1997-12-30 Meadox Medicals, Inc. Method of providing a substrate with a hydrophilic coating and substrates, particularly medical devices, provided with such coatings
US5605696A (en) 1995-03-30 1997-02-25 Advanced Cardiovascular Systems, Inc. Drug loaded polymeric material and method of manufacture
US5674242A (en) 1995-06-06 1997-10-07 Quanam Medical Corporation Endoprosthetic device with therapeutic compound
US5620738A (en) 1995-06-07 1997-04-15 Union Carbide Chemicals & Plastics Technology Corporation Non-reactive lubicious coating process
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
EP0832618A1 (en) * 1996-09-25 1998-04-01 Terumo Kabushiki Kaisha Stent for dilating a stenotic lesion of a blood vessel
US5779732A (en) 1997-03-31 1998-07-14 Medtronic, Inc. Method and apparatus for implanting a film with an exandable stent

Non-Patent Citations (23)

* Cited by examiner, † Cited by third party
Title
"A Powerful Case For LOPID", Parke-Davis, dated prior to Jan. 8, 1999.
Bartoli et al., "In Vitro and In Vivo Antitumoral Activity of Free, and Encapsulated Taxol", J. Microencapsulation, vol. 7, No. 2 (1990) pp. 191-197.
Bruck, Stephen D., "Interactions of Synthetic and natural surfaces with blood in the Physiological Environment," J. Biomed. Mater. Res. Symposium, No. 8 (1997) pp. 1-21.
Cox, D. A. et al., "Local Delivery of Heparin and Methotrexate Fails to Inhibit In Vivo Smooth Muscle Cell Proliferation", Supplement to Circulation Abstracts From the 64th Scientific Sessions, vol. 84, No. 4, Abstract No. 0284, 1991, p. II-71.
Cox, David A., M.D. et al., "Effect of Local Delivery of Heparin and Methotrexate on Neointimal Proliferation in Stented Porcine Coronary Arteries", Coronary Artery Disease, vol. 3, No. 3, Mar. 1992, pp. 237-248.
Dev, V. et al. "Kinetics of Drug Delivery to the Arterial Wall Via Polyurethane Coated Removable Nitinol Stent-Comparative Study of 2 Drugs", Circulation Abstracts From the 66th Scientific Sessions, vol. 88, No. 4, Part 2, Abstract No. 1657 (1993) p. I-3.
Esquivel, Carlos O., M.D. et al., "Reduced Thrombogenic Characteristics of Expanded Polytetrafluoroethylene and Polyurethane Arterial Grafts After Heparin Bonding", Surgery, Jan. 1984, pp. 102-107.
Guyton, John R. et al., "Inhibition of Rat arterial Smooth Muscle Cell Prolicferation by Heparin," Circulation Research, vol. 46, No. 5, May 1980, pp. 625-634.
Jampel, Henry D., M.D. et al., "In Vitro Release of Hydrophobic Drugs From Polyanhydride Disks", Ophthalmic Surgery, dated prior to Jan. 8, 1991.
Kawahito, Koji et al., "Heparin Coated Percutaneous Cardiopulmonary Support for the Treatment of Circulatory Collapse After Cardiac Surgery," ASAIO Journal vol. 40, No. 4, Oct-Dec 1994, pp. 972-976.
Kishida, Akio et al., "Immobilization of Human Thrombomodulin onto Biomaterials," ASAIO Journal , Slide Forum-Materials 4 (1994) pp. M840-M845.
Kishida, Akio et al., "Immobilization of Human Thrombomodulin onto Biomaterials," ASAIO Journal , Slide Forum—Materials 4 (1994) pp. M840-M845.
Lambert, T. et al., "A New Method For Arterial Drug Delivery Removable Stent", JACC, vol. 21, No. 2, Abstract No. 334-2 (1993) p. 483A.
Lambert, T. et al., "Localized Arterial Drug Delivery From a Polymer Coated Removable Metallic Stent: Kinetics and Bioactivity of Forskolin", Circulation Abstracts From the 66th Scientific Sessions, vol. 88, No. 4, Part 2, Abstract No. 1659 (1993) p. I-3.
Linhardt, Robert J. et al., "Differential Anticoagulant Activity of Heparin Fragments Prepared Using Microbial Heparinase," The Journal of Biological Chemistry, vol. 257, No. 13, Jul. 10, 19xx, pp. 7310-7313.
Miyama, Hajime et al., "A New Antithrombogenic Heparinized Polymer," J. Biomed Mater. Res., vol. 11 (1977) pp. 251-265.
Moses, Marsha A. et al., Inhibitors of Angiogenesis, Review, The Children's Hopsital Medical Center, Boston, MA, dated prior to Jan. 8, 1999.
Nichols, Allen B. et al., "Effect of Heparin Bonding on Catheter-induced Fibrin Formatioin and Platelet Activation," Circulation, vol. 70, No. 5, Nov. 1984, pp. 843-850.
Pitt, C.G. et al., "The Design of Controlled Drug Delivery Systems Based on Biodegredable Polymers", Progress in Contraceptive Delivery Systems, M T P Press, Lancaster, vol. 1 (1980) pp. 17-18.
Sheppeck, Richard A. et al., "Examination of the Roles of Glycoprotein Ib and Glycoprotein IIb/IIIa in Platelet Deposition on an Artifical Surface Using Clinical Antiplatelet Agents and Monoclonal Antibody Blockade," Blood, vol. 78, No. 3, Aug. 1, 1991, pp. 673-680.
Tang, Chris et al., "Regression of Collagen-Induced Arthritis with Taxol, A Microtubule Stabilizer", Arthritis Rheum., vol. 36, No. 9 (Suppl.) (1993) p. 42.
Whitborne, Richard, Ph.D., Presentation at the 2nd International Coronary Stenting Summit (Mar. 1-2, 1991).
Wilson, Dr. Joseph, "Thromboresistant Plastic Coating Treatment," Research Partners, Inc., Internet Article dated Jan. 21, 1991, 2 pages.

Cited By (586)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070003630A1 (en) * 1993-07-19 2007-01-04 Angiotech Pharmaceuticals, Inc. Anti-angiogenic compositions and methods of use
US20060127445A1 (en) * 1993-07-19 2006-06-15 Angiotech Pharmaceuticals, Inc. Anti-angiogenic compositions and methods of use
US20060240113A1 (en) * 1993-07-19 2006-10-26 Angiotech Pharmaceuticals, Inc. Anti-angiogenic compositions and methods of use
US20070003629A1 (en) * 1993-07-19 2007-01-04 Angiotech Pharmaceuticals, Inc. Anti-angiogenic compositions and methods of use
US20100240742A1 (en) * 1993-07-19 2010-09-23 Angiotech Pharmaceuticals, Inc. Anti-angiogenic compositions and methods of use
US20060121117A1 (en) * 1993-07-19 2006-06-08 Angiotech Pharmaceuticals, Inc. Anti-angiogenic compositions and methods of use
US7820193B2 (en) 1993-07-19 2010-10-26 Angiotech Pharmaceuticals, Inc. Anti-angiogenic compositions and methods of use
US20040076672A1 (en) * 1993-07-19 2004-04-22 Angiotech Pharmaceuticals, Inc. Anti-angiogenic compositions and methods of use
US6544544B2 (en) 1993-07-19 2003-04-08 Angiotech Pharmaceuticals, Inc. Anti-angiogenic compositions and methods of use
US8221794B2 (en) * 1993-07-19 2012-07-17 Angiotech Pharmaceuticals, Inc. Anti-angiogenic nanoparticle compositions
US8329945B2 (en) 1996-03-26 2012-12-11 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US20100137196A1 (en) * 1996-03-26 2010-06-03 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US8399233B2 (en) 1996-03-26 2013-03-19 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US8426592B2 (en) 1996-03-26 2013-04-23 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US8329946B2 (en) 1996-03-26 2012-12-11 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US20110218154A1 (en) * 1996-03-26 2011-09-08 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US20070093413A1 (en) * 1996-03-26 2007-04-26 Harvard University Oti Histone deacetylases, and uses related thereto
US8362084B2 (en) 1996-03-26 2013-01-29 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US20060025726A1 (en) * 1996-06-04 2006-02-02 Vance Products Incorporated, D/B/A Cook Urological Incorporated Implantable medical device with pharmacologically active layer
US20060030826A1 (en) * 1996-06-04 2006-02-09 Vance Products Incorporated,d/b/a Cook Urological Incorporated Implantable medical device with anti-neoplastic drug
US20060052757A1 (en) * 1996-06-04 2006-03-09 Vance Products Incorporated, D/B/A Cook Urological Incorporated Implantable medical device with analgesic or anesthetic
US7766955B2 (en) 1996-11-04 2010-08-03 Boston Scientific Scimed, Inc. Extendible stent apparatus
US9561126B2 (en) 1996-11-04 2017-02-07 Boston Scientific Scimed, Inc. Catheter with attached flexible side sheath
US8771342B2 (en) 1996-11-04 2014-07-08 Boston Scientific Scimed, Inc. Methods for deploying stents in bifurcations
US7678142B2 (en) 1996-11-04 2010-03-16 Boston Scientific Scimed, Inc. Extendible stent apparatus
US7850725B2 (en) 1996-11-04 2010-12-14 Boston Scientific Scimed, Inc. Extendible stent apparatus
US8241349B2 (en) 1998-01-14 2012-08-14 Boston Scientific Scimed, Inc. Extendible stent apparatus
US7892279B2 (en) 1998-01-14 2011-02-22 Boston Scientific Scimed, Inc. Extendible stent apparatus
US20040133268A1 (en) * 1998-01-14 2004-07-08 Advanced Stent Technologies, Inc. Extendible stent apparatus
US20030216352A1 (en) * 1998-03-11 2003-11-20 Surface Solutions Laboratories, Inc. Multicomponent complex for use with a substrate
US20090163995A1 (en) * 1998-03-30 2009-06-25 Shanley John F Expandable medical device for delivery of beneficial agent
US20080249609A1 (en) * 1998-03-30 2008-10-09 Shanley John F Expandable medical device with ductile hinges
US8439968B2 (en) 1998-03-30 2013-05-14 Innovational Holdings, Llc Expandable medical device for delivery of beneficial agent
US8052735B2 (en) 1998-03-30 2011-11-08 Innovational Holdings, Llc Expandable medical device with ductile hinges
US7909865B2 (en) 1998-03-30 2011-03-22 Conor Medsystems, LLC Expandable medical device for delivery of beneficial agent
US7896912B2 (en) 1998-03-30 2011-03-01 Innovational Holdings, Llc Expandable medical device with S-shaped bridging elements
US7819912B2 (en) 1998-03-30 2010-10-26 Innovational Holdings Llc Expandable medical device with beneficial agent delivery mechanism
US20030009214A1 (en) * 1998-03-30 2003-01-09 Shanley John F. Medical device with beneficial agent delivery mechanism
US8052734B2 (en) 1998-03-30 2011-11-08 Innovational Holdings, Llc Expandable medical device with beneficial agent delivery mechanism
US8206435B2 (en) 1998-03-30 2012-06-26 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US20080294242A1 (en) * 1998-03-30 2008-11-27 Shanley John F Expandable medical device with ductile hinges
US8066763B2 (en) 1998-04-11 2011-11-29 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
US7842078B2 (en) * 1998-09-05 2010-11-30 Abbott Laboratories Vascular Enterprises Limited Apparatus for a stent having an expandable web structure and delivery system
US7811314B2 (en) 1998-09-05 2010-10-12 Abbott Laboratories Vascular Enterprises Limited Methods and apparatus for stenting comprising enhanced embolic protection coupled with improved protections against restenosis and thrombus formation
US8343208B2 (en) 1998-09-05 2013-01-01 Abbott Laboratories Vascular Enterprises Limited Stent having an expandable web structure
US7815672B2 (en) * 1998-09-05 2010-10-19 Abbott Laboratories Vascular Enterprises Limited Apparatus for a stent having an expandable web structure
US7842079B2 (en) * 1998-09-05 2010-11-30 Abbott Laboratories Vascular Enterprises Limited Apparatus for a stent having an expandable web structure and delivery system
US7846196B2 (en) * 1998-09-05 2010-12-07 Abbott Laboratories Vascular Enterprises Limited Apparatus for a stent having an expandable web structure
US8303645B2 (en) 1998-09-05 2012-11-06 Abbott Laboratories Vascular Enterprises Limited Methods and apparatus for a stent having an expandable web structure
US9517146B2 (en) 1998-09-05 2016-12-13 Abbott Laboratories Vascular Enterprises Limited Methods and apparatus for stenting comprising enhanced embolic protection coupled with improved protections against restenosis and thrombus formation
US7794491B2 (en) * 1998-09-05 2010-09-14 Abbott Laboratories Vascular Enterprises Limited Apparatus for a stent having an expandable web structure and delivery system
US7887577B2 (en) * 1998-09-05 2011-02-15 Abbott Laboratories Vascular Enterprises Limited Apparatus for a stent having an expandable web structure
US7789904B2 (en) * 1998-09-05 2010-09-07 Abbott Laboratories Vascular Enterprises Limited Methods and apparatus for a stent having an expandable web structure
US7927364B2 (en) 1998-09-05 2011-04-19 Abbott Laboratories Vascular Enterprises Limited Methods and apparatus for stenting comprising enhanced embolic protection coupled with improved protections against restenosis and thrombus formation
US7927365B2 (en) 1998-09-05 2011-04-19 Abbott Laboratories Vascular Enterprises Limited Methods and apparatus for stenting comprising enhanced embolic protection coupled with improved protections against restenosis and thrombus formation
US7887578B2 (en) * 1998-09-05 2011-02-15 Abbott Laboratories Vascular Enterprises Limited Stent having an expandable web structure
US8814926B2 (en) 1998-09-05 2014-08-26 Abbott Laboratories Vascular Enterprises Limited Methods and apparatus for stenting comprising enhanced embolic protection coupled with improved protections against restenosis and thrombus formation
US20050004659A1 (en) * 1998-09-05 2005-01-06 Abbott Laboratories Vascular Enterprises Limited Methods and apparatus for stent having an expandable web structure
US20050004662A1 (en) * 1998-09-05 2005-01-06 Abbott Laboratories Vascular Enterprises Limited Methods and apparatus for a drug-coated stent having an expandable web structure
US8088157B2 (en) 1998-09-05 2012-01-03 Abbott Laboratories Vascular Enterprises Limited Methods and apparatus for stenting comprising enhanced embolic protection coupled with improved protections against restenosis and thrombus formation
US20050004651A1 (en) * 1998-09-05 2005-01-06 Abbott Laboratories Vascular Enterprises Limited Methods and apparatus for a stent having an expandable web structure and delivery system
US7789905B2 (en) * 1998-09-05 2010-09-07 Abbottt Laboratories Vascular Enterprises Limited Apparatus for a stent having an expandable web structure
US9050442B2 (en) 1999-01-25 2015-06-09 Atrium Medical Corporation Expandable fluoropolymer device for delivery of therapeutic agents and method of making
US20080015500A1 (en) * 1999-01-25 2008-01-17 Atrium Medical Corporation Application of a therapeutic substance to a tissue location using an expandable medical device
US20110118703A1 (en) * 1999-01-25 2011-05-19 Herweck Steve A Expandable fluoropolymer device for delivery of therapeutic agents and method of making
US7947015B2 (en) 1999-01-25 2011-05-24 Atrium Medical Corporation Application of a therapeutic substance to a tissue location using an expandable medical device
US7771462B1 (en) 1999-06-04 2010-08-10 Boston Scientific Scimed, Inc. Catheter with side sheath and methods
US6569195B2 (en) * 1999-07-02 2003-05-27 Scimed Life Systems, Inc. Stent coating
US7807211B2 (en) 1999-09-03 2010-10-05 Advanced Cardiovascular Systems, Inc. Thermal treatment of an implantable medical device
US7682647B2 (en) 1999-09-03 2010-03-23 Advanced Cardiovascular Systems, Inc. Thermal treatment of a drug eluting implantable medical device
US20040220665A1 (en) * 1999-09-03 2004-11-04 Hossainy Syed F.A. Thermal treatment of a drug eluting implantable medical device
US20030060783A1 (en) * 1999-12-03 2003-03-27 Koole Levinus Hendrik Wire, tube or catheter with hydrophilic coating
US20080033373A1 (en) * 1999-12-03 2008-02-07 Angiodevice International Gmbh Wire, tube or catheter with hydrophilic coating
US8211167B2 (en) 1999-12-06 2012-07-03 Boston Scientific Scimed, Inc. Method of using a catheter with attached flexible side sheath
US20090305384A1 (en) * 2000-03-03 2009-12-10 President And Fellows Of Harvard College Class II Human Histone Deacetylases, and Uses Related Thereto
US8895284B2 (en) 2000-03-03 2014-11-25 President And Fellows Of Harvard College Class II human histone deacetylases, and uses related thereto
US8076116B2 (en) 2000-03-03 2011-12-13 President And Fellows Of Harvard College Nucleic acids encoding class II human histone deacetylases, and uses related thereto
US8435780B2 (en) 2000-03-03 2013-05-07 President And Fellows Of Harvard College Class II human histone deacetylases, and uses related thereto
US20060135476A1 (en) * 2000-03-15 2006-06-22 Orbus Medical Technologies, Inc. Medical device with coating that promotes endothelial cell adherence and differentiation
US20070128723A1 (en) * 2000-03-15 2007-06-07 Orbusneich Medical, Inc. Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device
US20070042017A1 (en) * 2000-03-15 2007-02-22 Orbus Medical Technologies, Inc. Medical device with coating that promotes endothelial cell adherence and differentiation
US20070141107A1 (en) * 2000-03-15 2007-06-21 Orbusneich Medical, Inc. Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device
US20060121012A1 (en) * 2000-03-15 2006-06-08 Orbus Medical Technologies, Inc. Medical device with coating for capturing genetically-altered cells and methods of using same
US9364565B2 (en) 2000-03-15 2016-06-14 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods of using same
US8460367B2 (en) 2000-03-15 2013-06-11 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US7803183B2 (en) 2000-03-15 2010-09-28 Orbusneich Medical, Inc. Medical device with coating that promotes endothelial cell adherence
US9789001B2 (en) 2000-04-14 2017-10-17 Dose Medical Corporation Ocular implant with therapeutic agents and methods thereof
US9066782B2 (en) 2000-04-14 2015-06-30 Dose Medical Corporation Ocular implant with therapeutic agents and methods thereof
US8814820B2 (en) * 2000-04-14 2014-08-26 Glaukos Corporation Ocular implant with therapeutic agent and methods thereof
US7682648B1 (en) 2000-05-31 2010-03-23 Advanced Cardiovascular Systems, Inc. Methods for forming polymeric coatings on stents
US6869973B2 (en) 2000-06-22 2005-03-22 Nitromed, Inc. Nitrosated and nitrosylated taxanes, compositions and methods of use
US6656966B2 (en) 2000-06-22 2003-12-02 Nitromed, Inc. Nitrosated and nitrosylated taxanes, compositions and methods of use
US20040047978A1 (en) * 2000-08-04 2004-03-11 Hossainy Syed F.A. Composition for coating an implantable prosthesis
US6986899B2 (en) 2000-08-04 2006-01-17 Advanced Cardiovascular Systems, Inc. Composition for coating an implantable prosthesis
US20020032478A1 (en) * 2000-08-07 2002-03-14 Percardia, Inc. Myocardial stents and related methods of providing direct blood flow from a heart chamber to a coronary vessel
US7691401B2 (en) 2000-09-28 2010-04-06 Advanced Cardiovascular Systems, Inc. Poly(butylmethacrylate) and rapamycin coated stent
US20040232587A1 (en) * 2000-10-03 2004-11-25 Atrium Medical Corp. Method for forming expandable polymers having drugs or agents included therewith
US6923927B2 (en) 2000-10-03 2005-08-02 Atrium Medical Corporation Method for forming expandable polymers having drugs or agents included therewith
US6764507B2 (en) 2000-10-16 2004-07-20 Conor Medsystems, Inc. Expandable medical device with improved spatial distribution
US20060149357A1 (en) * 2000-10-16 2006-07-06 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US7850728B2 (en) 2000-10-16 2010-12-14 Innovational Holdings Llc Expandable medical device for delivery of beneficial agent
US8187321B2 (en) 2000-10-16 2012-05-29 Innovational Holdings, Llc Expandable medical device for delivery of beneficial agent
US7807210B1 (en) 2000-10-31 2010-10-05 Advanced Cardiovascular Systems, Inc. Hemocompatible polymers on hydrophobic porous polymers
US9107605B2 (en) 2000-11-17 2015-08-18 Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. Device for in vivo delivery of bioactive agents and method of manufacture thereof
US20050186241A1 (en) * 2000-11-17 2005-08-25 Boyle Christopher T. Device for in vivo delivery of bioactive agents and method of manufacture thereof
US7678143B2 (en) 2000-12-22 2010-03-16 Advanced Cardiovascular Systems, Inc. Ethylene-carboxyl copolymers as drug delivery matrices
US20040096504A1 (en) * 2000-12-22 2004-05-20 Gene Michal Ethylene-carboxyl copolymers as drug delivery matrices
US7820190B2 (en) 2000-12-28 2010-10-26 Advanced Cardiovascular Systems, Inc. Coating for implantable devices and a method of forming the same
US20040047980A1 (en) * 2000-12-28 2004-03-11 Pacetti Stephen D. Method of forming a diffusion barrier layer for implantable devices
US20020107563A1 (en) * 2001-02-05 2002-08-08 Shanley John F. Expandable medical device with locking mechanism
US20080286278A1 (en) * 2001-03-07 2008-11-20 Biomed Solutions, Llc Process for in vivo treatment of specific biological targets in bodily fluids
US8507212B2 (en) 2001-03-07 2013-08-13 Biomed Solutions Llc Process for in vivo treatment of specific biological targets in bodily fluids
US8105793B2 (en) 2001-03-07 2012-01-31 Biomed Solutions, Llc Process for in vivo treatment of specific biological targets in bodily fluids
US20020163504A1 (en) * 2001-03-13 2002-11-07 Pallakoff Matthew G. Hand-held device that supports fast text typing
US20030054036A1 (en) * 2001-03-13 2003-03-20 Richard Liggins Micellar drug delivery vehicles and precursors thereto and uses thereof
US20030157170A1 (en) * 2001-03-13 2003-08-21 Richard Liggins Micellar drug delivery vehicles and precursors thereto and uses thereof
US7875677B2 (en) 2001-04-20 2011-01-25 The University Of British Columbia Micellar drug delivery systems for hydrophobic drugs
US8110243B2 (en) 2001-04-24 2012-02-07 Advanced Cardiovascular Systems, Inc. Coating for a stent and a method of forming the same
US20080215141A1 (en) * 2001-04-24 2008-09-04 Syed Faiyaz Ahmed Hossainy Coating for a Stent and a Method of Forming the Same
US20040073298A1 (en) * 2001-04-24 2004-04-15 Hossainy Syed Faiyaz Ahmed Coating for a stent and a method of forming the same
US8178579B2 (en) 2001-05-09 2012-05-15 President And Fellows Of Harvard College Dioxanes and uses thereof
US8603536B2 (en) 2001-05-09 2013-12-10 Advanced Cardiovascular Systems, Inc. Microparticle coated medical device
US20040052858A1 (en) * 2001-05-09 2004-03-18 Wu Steven Z. Microparticle coated medical device
US20040052859A1 (en) * 2001-05-09 2004-03-18 Wu Steven Z. Microparticle coated medical device
US8361539B2 (en) 2001-05-09 2013-01-29 Advanced Cardiovascular Systems, Inc. Methods of forming microparticle coated medical device
US8617231B2 (en) 2001-05-18 2013-12-31 Boston Scientific Scimed, Inc. Dual guidewire exchange catheter system
US7335391B1 (en) 2001-05-31 2008-02-26 Advanced Cardiovascular Systems, Inc. Method for coating implantable devices
US20080102193A1 (en) * 2001-05-31 2008-05-01 Pacetti Stephen D Method For Coating Implantable Devices
US7985440B2 (en) 2001-06-27 2011-07-26 Advanced Cardiovascular Systems, Inc. Method of using a mandrel to coat a stent
US8741378B1 (en) 2001-06-27 2014-06-03 Advanced Cardiovascular Systems, Inc. Methods of coating an implantable device
US7682669B1 (en) 2001-07-30 2010-03-23 Advanced Cardiovascular Systems, Inc. Methods for covalently immobilizing anti-thrombogenic material into a coating on a medical device
US20060064157A1 (en) * 2001-08-20 2006-03-23 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US7850727B2 (en) 2001-08-20 2010-12-14 Innovational Holdings, Llc Expandable medical device for delivery of beneficial agent
US7842083B2 (en) 2001-08-20 2010-11-30 Innovational Holdings, Llc. Expandable medical device with improved spatial distribution
US8303651B1 (en) 2001-09-07 2012-11-06 Advanced Cardiovascular Systems, Inc. Polymeric coating for reducing the rate of release of a therapeutic substance from a stent
US7989018B2 (en) 2001-09-17 2011-08-02 Advanced Cardiovascular Systems, Inc. Fluid treatment of a polymeric coating on an implantable medical device
US8425590B2 (en) 2001-09-24 2013-04-23 Boston Scientific Scimed, Inc. Stent with protruding branch portion for bifurcated vessels
US20060036315A1 (en) * 2001-09-24 2006-02-16 Advanced Stent Technologies, Inc. Stent with protruding branch portion for bifurcated vessels
US7578841B2 (en) 2001-09-24 2009-08-25 Boston Scientific Scimed, Inc. Stent with protruding branch portion for bifurcated vessels
US20070191938A1 (en) * 2001-09-27 2007-08-16 Advanced Cardiovascular Systems, Inc. Remote activation of an implantable device
US20070191937A1 (en) * 2001-09-27 2007-08-16 Advanced Cardiovascular Systems, Inc. Remote activation of an implantable device
US7223282B1 (en) 2001-09-27 2007-05-29 Advanced Cardiovascular Systems, Inc. Remote activation of an implantable device
US7815763B2 (en) 2001-09-28 2010-10-19 Abbott Laboratories Vascular Enterprises Limited Porous membranes for medical implants and methods of manufacture
US9333279B2 (en) 2001-10-22 2016-05-10 Covidien Lp Coated stent comprising an HMG-CoA reductase inhibitor
US8449905B2 (en) 2001-10-22 2013-05-28 Covidien Lp Liquid and low melting coatings for stents
US20030083740A1 (en) * 2001-10-22 2003-05-01 Chandrashekhar Pathak Liquid and low melting coatings for stents
US8900618B2 (en) 2001-10-22 2014-12-02 Covidien Lp Liquid and low melting coatings for stents
US20060165752A1 (en) * 2001-10-22 2006-07-27 Ev3 Peripheral, Inc. Coated stent
US20110064868A1 (en) * 2001-10-22 2011-03-17 Ev3 Peripheral, Inc. Liquid and low melting coatings for stents
US20050038505A1 (en) * 2001-11-05 2005-02-17 Sun Biomedical Ltd. Drug-delivery endovascular stent and method of forming the same
US20030088307A1 (en) * 2001-11-05 2003-05-08 Shulze John E. Potent coatings for stents
US8308795B2 (en) 2001-11-05 2012-11-13 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method of forming the same
US20060229706A1 (en) * 2001-11-05 2006-10-12 Shulze John E Drug-Delivery Endovascular Stent and Method for Treating Restenosis
US7727275B2 (en) 2001-11-05 2010-06-01 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method of forming the same
US20100312328A1 (en) * 2001-11-05 2010-12-09 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method of forming the same
US20030099765A1 (en) * 2001-11-26 2003-05-29 Swaminathan Jayaraman Process for coating a surface of a stent
US6821549B2 (en) 2001-11-26 2004-11-23 Vascular Concept Holdings Limited Process for coating a surface of a stent
US6517889B1 (en) 2001-11-26 2003-02-11 Swaminathan Jayaraman Process for coating a surface of a stent
US6641611B2 (en) 2001-11-26 2003-11-04 Swaminathan Jayaraman Therapeutic coating for an intravascular implant
US20040137066A1 (en) * 2001-11-26 2004-07-15 Swaminathan Jayaraman Rationally designed therapeutic intravascular implant coating
US7115300B1 (en) 2001-12-28 2006-10-03 Advanced Cardiovascular Systems, Inc. Method of coating implantable medical devices
US20060019023A1 (en) * 2001-12-28 2006-01-26 Hossainy Syed F Method of coating implantable medical devices
US7601384B2 (en) 2001-12-28 2009-10-13 Advanced Cardiovascular Systems, Inc. Method of coating implantable medical devices
US20060286287A1 (en) * 2001-12-28 2006-12-21 Advanced Cardiovascular Systems, Inc. Method of coating implantable medical devices
US20030163187A1 (en) * 2002-02-25 2003-08-28 Jan Weber Non-invasive heating of implanted vascular treatment device
US7918883B2 (en) 2002-02-25 2011-04-05 Boston Scientific Scimed, Inc. Non-invasive heating of implanted vascular treatment device
EP2308861A1 (en) 2002-03-08 2011-04-13 Eisai R&D Management Co., Ltd. Macrocyclic compounds useful as pharmaceuticals
WO2003077967A1 (en) * 2002-03-16 2003-09-25 Aachen Resonance Entwicklung- Sgesellschaft Für Magnetresonanz - Kompatible Medizinprodukte Mbh Deposition method for endoprostheses provided for constantly administering medicaments
US20050163914A1 (en) * 2002-03-16 2005-07-28 Doris Klee Deposition method for endoprostheses provided for constantly administering medicaments
US7919075B1 (en) 2002-03-20 2011-04-05 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices
US8563025B2 (en) 2002-03-20 2013-10-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices
WO2003082268A2 (en) 2002-03-22 2003-10-09 Eisai Co. Ltd Hemiasterlin derivatives and uses thereof in the treatment of cancer
EP2374454A1 (en) 2002-03-22 2011-10-12 Eisai R&D Management Co., Ltd. Hemiasterlin derivatives and uses thereof in the treatment of cancer
US8961588B2 (en) 2002-03-27 2015-02-24 Advanced Cardiovascular Systems, Inc. Method of coating a stent with a release polymer for 40-O-(2-hydroxy)ethyl-rapamycin
US8173199B2 (en) 2002-03-27 2012-05-08 Advanced Cardiovascular Systems, Inc. 40-O-(2-hydroxy)ethyl-rapamycin coated stent
US7931932B2 (en) 2002-04-04 2011-04-26 Boston Scientific Scimed, Inc. Processes for producing polymer coatings through surface polymerization
US20080145516A1 (en) * 2002-04-04 2008-06-19 Boston Scientific Scimed, Inc. Processes for producing polymer coatings through surface polymerization
DE10216971A1 (en) * 2002-04-16 2003-10-30 Lothar Sellin Medical implant, e.g. stent, has drug combined directly or by drug release system with biocompatible e.g. hemocompatible surface coating e.g. of carbon, silicon carbide or pyrolytic carbon
US7387836B2 (en) 2002-04-17 2008-06-17 Genzyme Corporation Aziridine compounds and their use in medical devices
WO2003089026A1 (en) * 2002-04-17 2003-10-30 Genzyme Corporation Aziridine compounds and their use in medical devices
US20050249953A1 (en) * 2002-04-17 2005-11-10 Gianolio Diego A Aziridine compounds and their use in medical devices
EP2417943A1 (en) 2002-04-24 2012-02-15 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method for treating restenosis
US20040030380A1 (en) * 2002-04-24 2004-02-12 Sun Biomedical, Ltd. Drug-delivery endovascular stent and method for treating restenosis
US8545550B2 (en) 2002-04-24 2013-10-01 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method for treating restenosis
US20040024450A1 (en) * 2002-04-24 2004-02-05 Sun Biomedical, Ltd. Drug-delivery endovascular stent and method for treating restenosis
US8252046B2 (en) 2002-04-24 2012-08-28 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method for treating restenosis
US8715341B2 (en) 2002-04-24 2014-05-06 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method of forming the same
US7682387B2 (en) 2002-04-24 2010-03-23 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method for treating restenosis
EP2578186A2 (en) 2002-04-24 2013-04-10 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method for treating restenosis
EP2113230A2 (en) 2002-04-24 2009-11-04 Sun Biomedical, Ltd. Drug-Delivery Endovascular Stent and Method for Treating Restenosis
US20030203991A1 (en) * 2002-04-30 2003-10-30 Hydromer, Inc. Coating composition for multiple hydrophilic applications
US20040091605A1 (en) * 2002-05-24 2004-05-13 Biotronik Mess- Und Therapiegeraete Gmbh & Co Ingenieurbuero Berlin Method of coating a stent with a polysaccharide layer and associated stents
US7901703B2 (en) 2002-06-21 2011-03-08 Advanced Cardiovascular Systems, Inc. Polycationic peptides for cardiovascular therapy
US8506617B1 (en) 2002-06-21 2013-08-13 Advanced Cardiovascular Systems, Inc. Micronized peptide coated stent
US8067023B2 (en) 2002-06-21 2011-11-29 Advanced Cardiovascular Systems, Inc. Implantable medical devices incorporating plasma polymerized film layers and charged amino acids
US7803394B2 (en) 2002-06-21 2010-09-28 Advanced Cardiovascular Systems, Inc. Polycationic peptide hydrogel coatings for cardiovascular therapy
US7803406B2 (en) 2002-06-21 2010-09-28 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of coating implantable medical devices
US7875286B2 (en) 2002-06-21 2011-01-25 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of coating implantable medical devices
US7794743B2 (en) 2002-06-21 2010-09-14 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of making the same
US9084671B2 (en) 2002-06-21 2015-07-21 Advanced Cardiovascular Systems, Inc. Methods of forming a micronized peptide coated stent
USRE45500E1 (en) 2002-06-25 2015-04-28 Biointeractions Ltd. Polymeric network system for medical devices and methods of use
US20050043788A1 (en) * 2002-06-27 2005-02-24 Microport Medical Co., Ltd. Drug-eluting stent
CN100471469C (en) 2002-06-27 2009-03-25 微创医疗器械(上海)有限公司 Drug-eluting stent (DES) with multicoating
US20050033414A1 (en) * 2002-06-27 2005-02-10 Microport Medical Co. Ltd. Drug-eluting stent with multi-layer coatings
WO2004002367A1 (en) * 2002-06-27 2004-01-08 Microport Medical (Shanghai) Co., Ltd. Drug eluting stent
US7343659B2 (en) 2002-07-10 2008-03-18 Boston Scientific Scimed, Inc. Method of making a medical device
US20040010304A1 (en) * 2002-07-10 2004-01-15 Jan Weber Medical devices and methods of making the same
US8796212B2 (en) 2002-08-20 2014-08-05 Biosurface Engineering Technologies, Inc. Composition and method for delivery of BMP-2 amplifier/co-activator for enhancement of osteogenesis
US8227411B2 (en) 2002-08-20 2012-07-24 BioSurface Engineering Technologies, Incle FGF growth factor analogs
US8163717B2 (en) 2002-08-20 2012-04-24 Biosurface Engineering Technologies, Inc. Dual chain synthetic heparin-binding growth factor analogs
US20060199764A1 (en) * 2002-08-20 2006-09-07 Biosurface Engineering Technologies, Inc. FGF growth factor analogs
US7700563B2 (en) 2002-08-20 2010-04-20 Biosurface Engineering Technologies, Inc. Synthetic heparin-binding factor analogs
US20040087505A1 (en) * 2002-08-20 2004-05-06 Pena Louis A. Synthetic heparin-binding factor analogs
US20080166392A1 (en) * 2002-08-20 2008-07-10 Zamora Paul O Positive Modulator of Bone Morphogenic Protein-2
EP1549276A2 (en) * 2002-08-26 2005-07-06 HSU, Li-Chien Drug eluting coatings for medical implants
US20090043388A1 (en) * 2002-08-26 2009-02-12 Biovention Holdings Ltd. Drug eluting coatings for medical implants
US8753663B2 (en) 2002-08-26 2014-06-17 Biotegra, Inc. Drug eluting coatings for medical implants
US20050191333A1 (en) * 2002-08-26 2005-09-01 Biotegra, Inc. Drug eluting coatings for medical implants and methods of use
US8357386B2 (en) 2002-08-26 2013-01-22 Biotegra, Inc. Drug eluting coatings for medical implants and methods of use
US20040037886A1 (en) * 2002-08-26 2004-02-26 Li-Chien Hsu Drug eluting coatings for medical implants
US7438925B2 (en) * 2002-08-26 2008-10-21 Biovention Holdings Ltd. Drug eluting coatings for medical implants
EP1549276A4 (en) * 2002-08-26 2006-10-25 Li-Chien Hsu Drug eluting coatings for medical implants
CN100413540C (en) 2002-09-03 2008-08-27 微创医疗器械(上海)有限公司 Gene carrying rack and its producing method and use
US20050261756A1 (en) * 2002-09-03 2005-11-24 Bioneris Ab Coated stent
US20090175924A1 (en) * 2002-09-03 2009-07-09 Bioneris Ab Coated stent
US20040127976A1 (en) * 2002-09-20 2004-07-01 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
US9254202B2 (en) 2002-09-20 2016-02-09 Innovational Holdings Llc Method and apparatus for loading a beneficial agent into an expandable medical device
US20050234544A1 (en) * 2002-09-20 2005-10-20 Conor Medsystems, Inc. Expandable medical device with openings for delivery of multiple beneficial agents
US8349390B2 (en) 2002-09-20 2013-01-08 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
US20040073294A1 (en) * 2002-09-20 2004-04-15 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
US20030031699A1 (en) * 2002-09-30 2003-02-13 Medtronic Minimed, Inc. Polymer compositions containing bioactive agents and methods for their use
US6770729B2 (en) 2002-09-30 2004-08-03 Medtronic Minimed, Inc. Polymer compositions containing bioactive agents and methods for their use
US20040072922A1 (en) * 2002-10-09 2004-04-15 Hossainy Syed F.A. Rate limiting barriers for implantable medical devices
US7087263B2 (en) 2002-10-09 2006-08-08 Advanced Cardiovascular Systems, Inc. Rare limiting barriers for implantable medical devices
US20070053953A1 (en) * 2002-11-07 2007-03-08 Donald Verlee Method of loading beneficial agent to a prosthesis by fluid-jet application
US20040202773A1 (en) * 2002-11-07 2004-10-14 Donald Verlee Method of loading beneficial agent to a prosthesis by fluid-jet application
US8221495B2 (en) 2002-11-07 2012-07-17 Abbott Laboratories Integration of therapeutic agent into a bioerodible medical device
US9296011B2 (en) 2002-11-07 2016-03-29 Abbott Laboratories Prosthesis having varied concentration of beneficial agent
US20070189915A1 (en) * 2002-11-07 2007-08-16 Sanjay Shrivastava Method of integrating therapeutic agent into a bioerodible medical device
US20040254634A1 (en) * 2002-11-07 2004-12-16 Donald Verlee Prosthesis having varied concentration of beneficial agent
US7645476B2 (en) 2002-11-07 2010-01-12 Abbott Laboratories Method of loading beneficial agent to a prosthesis by fluid-jet application
US8524148B2 (en) 2002-11-07 2013-09-03 Abbott Laboratories Method of integrating therapeutic agent into a bioerodible medical device
US20100003396A1 (en) * 2002-11-07 2010-01-07 Abbott Laboratories System and Method of Loading and Detecting Beneficial Agent on a Prosthesis
US8001926B2 (en) 2002-11-07 2011-08-23 Abbott Laboratories System and method of loading and detecting beneficial agent on a prosthesis
US20080020129A1 (en) * 2002-11-07 2008-01-24 Abbott Laboratories Method of Loading Beneficial Agent to a Prosthesis by Fluid-Jet Application
US7208190B2 (en) 2002-11-07 2007-04-24 Abbott Laboratories Method of loading beneficial agent to a prosthesis by fluid-jet application
US7597764B2 (en) 2002-11-07 2009-10-06 Abbott Laboratories System of loading beneficial agent to a prosthesis by fluid-jet
US20040148016A1 (en) * 2002-11-07 2004-07-29 Klein Dean A. Biocompatible medical device coatings
US20040185081A1 (en) * 2002-11-07 2004-09-23 Donald Verlee Prosthesis with multiple drugs applied separately by fluid jet application in discrete unmixed droplets
US20040143321A1 (en) * 2002-11-08 2004-07-22 Conor Medsystems, Inc. Expandable medical device and method for treating chronic total occlusions with local delivery of an angiogenic factor
US20050273161A1 (en) * 2002-11-26 2005-12-08 Advanced Cardiovascular Systems, Inc. Electrostatic loading of drugs on implantable medical devices
US6982004B1 (en) 2002-11-26 2006-01-03 Advanced Cardiovascular Systems, Inc. Electrostatic loading of drugs on implantable medical devices
US7449210B2 (en) 2002-11-26 2008-11-11 Advanced Cardiovascular Systems, Inc. Electrostatic loading of drugs on implantable medical devices
US7468210B1 (en) 2002-12-10 2008-12-23 Biosurface Engineering Technologies, Inc. Cross-linked heparin coatings and methods
US7776926B1 (en) 2002-12-11 2010-08-17 Advanced Cardiovascular Systems, Inc. Biocompatible coating for implantable medical devices
US8986726B2 (en) 2002-12-11 2015-03-24 Abbott Cardiovascular Systems Inc. Biocompatible polyacrylate compositions for medical applications
US20050169957A1 (en) * 2002-12-11 2005-08-04 Hossainy Syed F. Biocompatible polyacrylate compositions for medical applications
US7758880B2 (en) 2002-12-11 2010-07-20 Advanced Cardiovascular Systems, Inc. Biocompatible polyacrylate compositions for medical applications
US8871236B2 (en) 2002-12-11 2014-10-28 Abbott Cardiovascular Systems Inc. Biocompatible polyacrylate compositions for medical applications
US8871883B2 (en) 2002-12-11 2014-10-28 Abbott Cardiovascular Systems Inc. Biocompatible coating for implantable medical devices
US8647655B2 (en) 2002-12-11 2014-02-11 Abbott Cardiovascular Systems Inc. Biocompatible polyacrylate compositions for medical applications
US7648725B2 (en) 2002-12-12 2010-01-19 Advanced Cardiovascular Systems, Inc. Clamp mandrel fixture and a method of using the same to minimize coating defects
US8435550B2 (en) 2002-12-16 2013-05-07 Abbot Cardiovascular Systems Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
US20060105019A1 (en) * 2002-12-16 2006-05-18 Gordon Stewart Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders
US8586069B2 (en) 2002-12-16 2013-11-19 Abbott Cardiovascular Systems Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders
US20100145251A1 (en) * 2003-02-03 2010-06-10 Hans-Dietrich Polaschegg Prevention of indwelling device related infection: compositions and methods
US20100145252A1 (en) * 2003-02-03 2010-06-10 Hans-Dietrich Polaschegg Prevention of indwelling device related infection: compositions and methods
US20040225346A1 (en) * 2003-02-05 2004-11-11 Mazumder Mark M. Encased stent
US7311727B2 (en) 2003-02-05 2007-12-25 Board Of Trustees Of The University Of Arkansas Encased stent
US20050143808A1 (en) * 2003-02-26 2005-06-30 Hossainy Syed F.A. Coating for implantable medical devices
US6926919B1 (en) 2003-02-26 2005-08-09 Advanced Cardiovascular Systems, Inc. Method for fabricating a coating for a medical device
US7247364B2 (en) 2003-02-26 2007-07-24 Advanced Cardiovascular Systems, Inc. Coating for implantable medical devices
US7563483B2 (en) 2003-02-26 2009-07-21 Advanced Cardiovascular Systems Inc. Methods for fabricating a coating for implantable medical devices
US20050196422A1 (en) * 2003-02-26 2005-09-08 Hossainy Syed F. Methods for fabricating a coating for implantable medical devices
US20040170752A1 (en) * 2003-02-28 2004-09-02 Luthra Ajay K. Polymeric network system for medical devices and methods of use
US7001421B2 (en) 2003-02-28 2006-02-21 Medtronic Vascular, Inc. Stent with phenoxy primer coating
US7655038B2 (en) 2003-02-28 2010-02-02 Biointeractions Ltd. Polymeric network system for medical devices and methods of use
US8449901B2 (en) 2003-03-28 2013-05-28 Innovational Holdings, Llc Implantable medical device with beneficial agent concentration gradient
US20040224080A1 (en) * 2003-05-06 2004-11-11 Epstein Samuel J. Processes for producing polymer coatings for release of therapeutic agent
US6923996B2 (en) 2003-05-06 2005-08-02 Scimed Life Systems, Inc. Processes for producing polymer coatings for release of therapeutic agent
US7390525B2 (en) 2003-05-06 2008-06-24 Boston Scientific Scimed, Inc. Processes for producing polymer coatings for release of therapeutic agent
US20050158359A1 (en) * 2003-05-06 2005-07-21 Epstein Samuel J. Processes for producing polymer coatings for release of therapeutic agent
US8673334B2 (en) 2003-05-08 2014-03-18 Abbott Cardiovascular Systems Inc. Stent coatings comprising hydrophilic additives
US20040224001A1 (en) * 2003-05-08 2004-11-11 Pacetti Stephen D. Stent coatings comprising hydrophilic additives
US9175162B2 (en) 2003-05-08 2015-11-03 Advanced Cardiovascular Systems, Inc. Methods for forming stent coatings comprising hydrophilic additives
US20040236279A1 (en) * 2003-05-22 2004-11-25 Atrium Medical Corp. Gaseous therapeutic agent delivery
US20040236410A1 (en) * 2003-05-22 2004-11-25 Atrium Medical Corp. Polymeric body formation
US20040236278A1 (en) * 2003-05-22 2004-11-25 Atrium Medical Corp. Therapeutic agent delivery
US20040249449A1 (en) * 2003-06-05 2004-12-09 Conor Medsystems, Inc. Drug delivery device and method for bi-directional drug delivery
WO2004108186A2 (en) 2003-06-05 2004-12-16 Conor Medsystems, Inc. Drug delivery device and method for bi-directional drug delivery
US20040253185A1 (en) * 2003-06-12 2004-12-16 Atrium Medical Corp. Medicated ink
US20040253281A1 (en) * 2003-06-12 2004-12-16 Atrium Medical Corp. Therapeutic markings applied to tissue
US7967998B2 (en) 2003-06-25 2011-06-28 Advanced Cardiocasvular Systems, Inc. Method of polishing implantable medical devices to lower thrombogenecity and increase mechanical stability
US7645504B1 (en) * 2003-06-26 2010-01-12 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices comprising hydrophobic and hydrophilic polymers
US20050004646A1 (en) * 2003-07-01 2005-01-06 Moriarty James W. Energy-activated adhesion layer for drug-polymer coated stent
US7655030B2 (en) 2003-07-18 2010-02-02 Boston Scientific Scimed, Inc. Catheter balloon systems and methods
US8771334B2 (en) 2003-07-18 2014-07-08 Boston Scientific Scimed, Inc. Catheter balloon systems and methods
US20050021127A1 (en) * 2003-07-21 2005-01-27 Kawula Paul John Porous glass fused onto stent for drug retention
US7455907B2 (en) 2003-07-30 2008-11-25 Advanced Cardiovascular Systems Inc. Hydrophobic biologically absorbable coatings for drug delivery devices and methods for fabricating the same
US20060182782A1 (en) * 2003-07-30 2006-08-17 Pacetti Stephen D Hydrophobic biologically absorbable coatings for drug delivery devices and methods for fabricating the same
US7056591B1 (en) 2003-07-30 2006-06-06 Advanced Cardiovascular Systems, Inc. Hydrophobic biologically absorbable coatings for drug delivery devices and methods for fabricating the same
US20080317939A1 (en) * 2003-07-31 2008-12-25 Advanced Cardiovascular Systems Inc. Method and System for Irradiation of a Drug Eluting Implantable Medical Device
US7431959B1 (en) 2003-07-31 2008-10-07 Advanced Cardiovascular Systems Inc. Method and system for irradiation of a drug eluting implantable medical device
US7785512B1 (en) 2003-07-31 2010-08-31 Advanced Cardiovascular Systems, Inc. Method and system of controlled temperature mixing and molding of polymers with active agents for implantable medical devices
US7645474B1 (en) 2003-07-31 2010-01-12 Advanced Cardiovascular Systems, Inc. Method and system of purifying polymers for use with implantable medical devices
US7887871B2 (en) 2003-07-31 2011-02-15 Advanced Cardiovascular Systems, Inc. Method and system for irradiation of a drug eluting implantable medical device
US7981862B2 (en) 2003-08-19 2011-07-19 Biosurface Engineering Technologies, Inc. Composition comprising BMP-2 amplifier/co-activator for enhancement of osteogenesis
US20080063622A1 (en) * 2003-08-19 2008-03-13 Biosurface Engineering Technologies, Inc. Composition and Method for Delivery of BMP-2 Amplifier/Co-Activator for Enhancement of Osteogenesis
US8298280B2 (en) 2003-08-21 2012-10-30 Boston Scientific Scimed, Inc. Stent with protruding branch portion for bifurcated vessels
US20050113687A1 (en) * 2003-09-15 2005-05-26 Atrium Medical Corporation Application of a therapeutic substance to a tissue location using a porous medical device
US20110213302A1 (en) * 2003-09-15 2011-09-01 Herweck Steve A Method of coating a folded medical device
US8021331B2 (en) 2003-09-15 2011-09-20 Atrium Medical Corporation Method of coating a folded medical device
US8308684B2 (en) 2003-09-15 2012-11-13 Atrium Medical Corporation Method of coating a folded medical device
US20060112536A1 (en) * 2003-09-15 2006-06-01 Atrium Medical Corporation Method of coating a folded medical device
US20050106206A1 (en) * 2003-09-15 2005-05-19 Atrium Medical Corporation Application of a therapeutic substance to a tissue location using an expandable medical device
US7572245B2 (en) 2003-09-15 2009-08-11 Atrium Medical Corporation Application of a therapeutic substance to a tissue location using an expandable medical device
US8197881B2 (en) 2003-09-22 2012-06-12 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
US7441513B1 (en) 2003-09-26 2008-10-28 Advanced Cardiovascular Systems, Inc. Plasma-generated coating apparatus for medical devices and a method of coating deposition
US20050070936A1 (en) * 2003-09-30 2005-03-31 Pacetti Stephen D. Coatings for drug delivery devices comprising hydrolitically stable adducts of poly(ethylene-co-vinyl alcohol) and methods for fabricating the same
US8197879B2 (en) 2003-09-30 2012-06-12 Advanced Cardiovascular Systems, Inc. Method for selectively coating surfaces of a stent
US7318932B2 (en) 2003-09-30 2008-01-15 Advanced Cardiovascular Systems, Inc. Coatings for drug delivery devices comprising hydrolitically stable adducts of poly(ethylene-co-vinyl alcohol) and methods for fabricating the same
US20050074544A1 (en) * 2003-10-07 2005-04-07 Pacetti Stephen D. System and method for coating a tubular implantable medical device
US7704544B2 (en) 2003-10-07 2010-04-27 Advanced Cardiovascular Systems, Inc. System and method for coating a tubular implantable medical device
US8052988B2 (en) 2003-11-06 2011-11-08 Advanced Cardiovascular Systems, Inc. Methods for fabricating coatings for drug delivery devices having gradient of hydration
US20080138497A1 (en) * 2003-11-06 2008-06-12 Pacetti Stephen D Methods For Fabricating Coatings For Drug Delivery Devices Having Gradient Of Hydration
US7329413B1 (en) 2003-11-06 2008-02-12 Advanced Cardiovascular Systems, Inc. Coatings for drug delivery devices having gradient of hydration and methods for fabricating thereof
US20080138498A1 (en) * 2003-11-06 2008-06-12 Pacetti Stephen D Methods For Fabricating Coatings For Drug Delivery Devices Having Gradient Of Hydration
US8277926B2 (en) 2003-11-06 2012-10-02 Advanced Cardiovascular Systems, Inc. Methods for fabricating coatings for drug delivery devices having gradient of hydration
US8231962B2 (en) 2003-11-06 2012-07-31 Advanced Cardiovascular Systems, Inc. Coatings for drug delivery devices having gradient of hydration
US20080113207A1 (en) * 2003-11-06 2008-05-15 Pacetti Stephen D Coatings For Drug Delivery Devices Having Gradient Of Hydration
US20050100577A1 (en) * 2003-11-10 2005-05-12 Parker Theodore L. Expandable medical device with beneficial agent matrix formed by a multi solvent system
US8702779B2 (en) 2003-11-12 2014-04-22 Boston Scientific Scimed, Inc. Catheter balloon systems and methods
US9114198B2 (en) 2003-11-19 2015-08-25 Advanced Cardiovascular Systems, Inc. Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same
US8192752B2 (en) 2003-11-21 2012-06-05 Advanced Cardiovascular Systems, Inc. Coatings for implantable devices including biologically erodable polyesters and methods for fabricating the same
US8017142B2 (en) 2003-11-25 2011-09-13 Advanced Cardiovascular Systems, Inc. Polysulfone block copolymers as drug-eluting coating material
US7560492B1 (en) 2003-11-25 2009-07-14 Advanced Cardiovascular Systems, Inc. Polysulfone block copolymers as drug-eluting coating material
US20090238856A1 (en) * 2003-11-25 2009-09-24 Advanced Cardiovascular Systems, Inc. Polysulfone block copolymers as drug-eluting coating material
US7807722B2 (en) 2003-11-26 2010-10-05 Advanced Cardiovascular Systems, Inc. Biobeneficial coating compositions and methods of making and using thereof
US20050112172A1 (en) * 2003-11-26 2005-05-26 Pacetti Stephen D. Biobeneficial coating compostions and methods of making and using thereof
USRE45744E1 (en) 2003-12-01 2015-10-13 Abbott Cardiovascular Systems Inc. Temperature controlled crimping
US8052912B2 (en) 2003-12-01 2011-11-08 Advanced Cardiovascular Systems, Inc. Temperature controlled crimping
US7786249B2 (en) 2003-12-19 2010-08-31 Advanced Cardiovascular Systems, Inc. Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents
US7772359B2 (en) 2003-12-19 2010-08-10 Advanced Cardiovascular Systems, Inc. Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents
US8309112B2 (en) 2003-12-24 2012-11-13 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices comprising hydrophilic substances and methods for fabricating the same
US20050147647A1 (en) * 2003-12-24 2005-07-07 Thierry Glauser Coatings for implantable medical devices comprising hydrophilic substances and methods for fabricating the same
US20080027531A1 (en) * 2004-02-12 2008-01-31 Reneker Darrell H Stent for Use in Cardiac, Cranial, and Other Arteries
US9670258B2 (en) 2004-02-20 2017-06-06 Ferring B.V. Positive modulator of bone morphogenic protein-2
US8685431B2 (en) 2004-03-16 2014-04-01 Advanced Cardiovascular Systems, Inc. Biologically absorbable coatings for implantable devices based on copolymers having ester bonds and methods for fabricating the same
US8551512B2 (en) 2004-03-22 2013-10-08 Advanced Cardiovascular Systems, Inc. Polyethylene glycol/poly(butylene terephthalate) copolymer coated devices including EVEROLIMUS
US20050208093A1 (en) * 2004-03-22 2005-09-22 Thierry Glauser Phosphoryl choline coating compositions
US20050232970A1 (en) * 2004-03-26 2005-10-20 Stucke Sean M Process and systems for biocompatible surfaces
US7550443B2 (en) 2004-03-26 2009-06-23 Surmodics, Inc. Process and systems for biocompatible surfaces
US20060216324A1 (en) * 2004-03-26 2006-09-28 Stucke Sean M Composition and method for preparing biocompatible surfaces
US7550444B2 (en) 2004-03-26 2009-06-23 Surmodics, Inc. Composition and method for preparing biocompatible surfaces
US20050244453A1 (en) * 2004-03-26 2005-11-03 Stucke Sean M Composition and method for preparing biocompatible surfaces
US8778014B1 (en) 2004-03-31 2014-07-15 Advanced Cardiovascular Systems, Inc. Coatings for preventing balloon damage to polymer coated stents
US7335264B2 (en) 2004-04-22 2008-02-26 Boston Scientific Scimed, Inc. Differentially coated medical devices, system for differentially coating medical devices, and coating method
US20050238829A1 (en) * 2004-04-22 2005-10-27 John Motherwell Differentially coated medical devices, system for differentially coating medical devices, and coating method
US9101697B2 (en) 2004-04-30 2015-08-11 Abbott Cardiovascular Systems Inc. Hyaluronic acid based copolymers
EP2946666A1 (en) 2004-04-30 2015-11-25 OrbusNeich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods of using same
US8293890B2 (en) 2004-04-30 2012-10-23 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers
US7820732B2 (en) 2004-04-30 2010-10-26 Advanced Cardiovascular Systems, Inc. Methods for modulating thermal and mechanical properties of coatings on implantable devices
US20050260557A1 (en) * 2004-05-21 2005-11-24 Mary Zacour Method of quantifying the cell-binding properties of a medical device
US9561309B2 (en) 2004-05-27 2017-02-07 Advanced Cardiovascular Systems, Inc. Antifouling heparin coatings
WO2005122959A2 (en) 2004-06-08 2005-12-29 Advanced Stent Technologies, Inc. Stent with protruding branch portion for bifurcated vessels
US9375445B2 (en) 2004-06-18 2016-06-28 Abbott Cardiovascular Systems Inc. Heparin prodrugs and drug delivery stents formed therefrom
US9364498B2 (en) 2004-06-18 2016-06-14 Abbott Cardiovascular Systems Inc. Heparin prodrugs and drug delivery stents formed therefrom
US8017140B2 (en) 2004-06-29 2011-09-13 Advanced Cardiovascular System, Inc. Drug-delivery stent formulations for restenosis and vulnerable plaque
US7758881B2 (en) 2004-06-30 2010-07-20 Advanced Cardiovascular Systems, Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
US8357391B2 (en) 2004-07-30 2013-01-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages
US8758801B2 (en) 2004-07-30 2014-06-24 Abbott Cardiocascular Systems Inc. Coatings for implantable devices comprising poly(hydroxy-alkanoates) and diacid linkages
US8586075B2 (en) 2004-07-30 2013-11-19 Abbott Cardiovascular Systems Inc. Coatings for implantable devices comprising poly(hydroxy-alkanoates) and diacid linkages
US9580558B2 (en) 2004-07-30 2017-02-28 Abbott Cardiovascular Systems Inc. Polymers containing siloxane monomers
US7648727B2 (en) 2004-08-26 2010-01-19 Advanced Cardiovascular Systems, Inc. Methods for manufacturing a coated stent-balloon assembly
US7766884B2 (en) 2004-08-31 2010-08-03 Advanced Cardiovascular Systems, Inc. Polymers of fluorinated monomers and hydrophilic monomers
US8110211B2 (en) 2004-09-22 2012-02-07 Advanced Cardiovascular Systems, Inc. Medicated coatings for implantable medical devices including polyacrylates
US8871292B2 (en) 2004-09-24 2014-10-28 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method for treating restenosis
US20060069427A1 (en) * 2004-09-24 2006-03-30 Savage Douglas R Drug-delivery endovascular stent and method for treating restenosis
US7901451B2 (en) 2004-09-24 2011-03-08 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method for treating restenosis
US8252047B2 (en) 2004-09-24 2012-08-28 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method for treating restenosis
US20060067952A1 (en) * 2004-09-28 2006-03-30 Sd Pharmaceuticals, Inc. Low oil emulsion compositions for delivering taxoids and other insoluble drugs
US8557861B2 (en) 2004-09-28 2013-10-15 Mast Therapeutics, Inc. Low oil emulsion compositions for delivering taxoids and other insoluble drugs
EP2462903A1 (en) 2004-10-13 2012-06-13 Tryton Medical, Inc. Stepped balloon catheter and prosthesis for treating vascular bifurcations
US9067000B2 (en) 2004-10-27 2015-06-30 Abbott Cardiovascular Systems Inc. End-capped poly(ester amide) copolymers
US8603634B2 (en) 2004-10-27 2013-12-10 Abbott Cardiovascular Systems Inc. End-capped poly(ester amide) copolymers
US7749263B2 (en) 2004-10-29 2010-07-06 Abbott Cardiovascular Systems Inc. Poly(ester amide) filler blends for modulation of coating properties
US8609123B2 (en) 2004-11-29 2013-12-17 Advanced Cardiovascular Systems, Inc. Derivatized poly(ester amide) as a biobeneficial coating
US7588642B1 (en) 2004-11-29 2009-09-15 Advanced Cardiovascular Systems, Inc. Abluminal stent coating apparatus and method using a brush assembly
US7892592B1 (en) 2004-11-30 2011-02-22 Advanced Cardiovascular Systems, Inc. Coating abluminal surfaces of stents and other implantable medical devices
US20060127443A1 (en) * 2004-12-09 2006-06-15 Helmus Michael N Medical devices having vapor deposited nanoporous coatings for controlled therapeutic agent delivery
US9339592B2 (en) 2004-12-22 2016-05-17 Abbott Cardiovascular Systems Inc. Polymers of fluorinated monomers and hydrocarbon monomers
US7699889B2 (en) 2004-12-27 2010-04-20 Advanced Cardiovascular Systems, Inc. Poly(ester amide) block copolymers
US20060142541A1 (en) * 2004-12-27 2006-06-29 Hossainy Syed F A Poly(ester amide) block copolymers
US8007775B2 (en) 2004-12-30 2011-08-30 Advanced Cardiovascular Systems, Inc. Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same
US20100298218A1 (en) * 2005-02-22 2010-11-25 Biosurface Engineering Technologies, Inc. Single Branch Heparin-Binding Growth Factor Analogs
US8101570B2 (en) 2005-02-22 2012-01-24 Biosurface Engineering Technologies, Inc. Single branch heparin-binding growth factor analogs
US20080227696A1 (en) * 2005-02-22 2008-09-18 Biosurface Engineering Technologies, Inc. Single branch heparin-binding growth factor analogs
US20060239909A1 (en) * 2005-03-22 2006-10-26 President And Fellows Of Harvard College Treatment of protein degradation disorders
US8999289B2 (en) 2005-03-22 2015-04-07 President And Fellows Of Harvard College Treatment of protein degradation disorders
US9572854B2 (en) 2005-03-22 2017-02-21 President And Fellows Of Harvard College Treatment of protein degradation disorders
US7795467B1 (en) 2005-04-26 2010-09-14 Advanced Cardiovascular Systems, Inc. Bioabsorbable, biobeneficial polyurethanes for use in medical devices
US8778375B2 (en) 2005-04-29 2014-07-15 Advanced Cardiovascular Systems, Inc. Amorphous poly(D,L-lactide) coating
US20060257355A1 (en) * 2005-05-10 2006-11-16 Abiomed, Inc. Impregnated polymer compositions and devices using them
US7823533B2 (en) 2005-06-30 2010-11-02 Advanced Cardiovascular Systems, Inc. Stent fixture and method for reducing coating defects
US8021676B2 (en) 2005-07-08 2011-09-20 Advanced Cardiovascular Systems, Inc. Functionalized chemically inert polymers for coatings
US9827117B2 (en) 2005-07-15 2017-11-28 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology
US8758429B2 (en) 2005-07-15 2014-06-24 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology
US7785647B2 (en) 2005-07-25 2010-08-31 Advanced Cardiovascular Systems, Inc. Methods of providing antioxidants to a drug containing product
US7735449B1 (en) 2005-07-28 2010-06-15 Advanced Cardiovascular Systems, Inc. Stent fixture having rounded support structures and method for use thereof
US9101949B2 (en) 2005-08-04 2015-08-11 Eilaz Babaev Ultrasonic atomization and/or seperation system
US20070031611A1 (en) * 2005-08-04 2007-02-08 Babaev Eilaz P Ultrasound medical stent coating method and device
US20080054091A1 (en) * 2005-08-04 2008-03-06 Bacoustics Llc Ultrasonic atomization and/or seperation system
US7896539B2 (en) 2005-08-16 2011-03-01 Bacoustics, Llc Ultrasound apparatus and methods for mixing liquids and coating stents
US20070051307A1 (en) * 2005-08-16 2007-03-08 Babaev Eilaz P Ultrasound apparatus and methods for mixing liquids and coating stents
US20070048351A1 (en) * 2005-09-01 2007-03-01 Prescient Medical, Inc. Drugs coated on a device to treat vulnerable plaque
US20070059530A1 (en) * 2005-09-14 2007-03-15 Ziegler Michael J Multi-component, waterborne coating compositions, related coatings and methods
US20080167431A1 (en) * 2005-09-14 2008-07-10 Ppg Industries Ohio, Inc. Multi-component, waterborne coating compositions, related coatings and methods
US7473442B2 (en) 2005-09-14 2009-01-06 Ppg Industries Ohio, Inc. Multi-component, waterborne coating compositions, related coatings and methods
WO2007056073A2 (en) * 2005-11-04 2007-05-18 Boston Scientific Limited (Barbados Home Office) Medical device with a coating comprising an active form and an inactive form of therapeutic agent(s)
WO2007056073A3 (en) * 2005-11-04 2007-08-30 Boston Scient Scimed Inc Medical device with a coating comprising an active form and an inactive form of therapeutic agent(s)
US7976891B1 (en) 2005-12-16 2011-07-12 Advanced Cardiovascular Systems, Inc. Abluminal stent coating apparatus and method of using focused acoustic energy
US7867547B2 (en) 2005-12-19 2011-01-11 Advanced Cardiovascular Systems, Inc. Selectively coating luminal surfaces of stents
US20070207173A1 (en) * 2006-02-01 2007-09-06 Sd Pharmaceuticals, Inc. Vitamin E succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof
US8470873B2 (en) 2006-02-01 2013-06-25 Mast Therapeutics, Inc. Vitamin E succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof
US8383855B2 (en) 2006-02-14 2013-02-26 President And Fellows Of Harvard College Histone deacetylase inhibitors
US8754237B2 (en) 2006-02-14 2014-06-17 President And Fellows Of Harvard College Bifunctional histone deacetylase inhibitors
US8222423B2 (en) 2006-02-14 2012-07-17 Dana-Farber Cancer Institute, Inc. Bifunctional histone deacetylase inhibitors
WO2008091349A1 (en) 2006-02-14 2008-07-31 The President And Fellows Of Harvard College Bifunctional histone deacetylase inhibitors
US20100056588A1 (en) * 2006-02-14 2010-03-04 Dana-Farber Cancer Institute, Inc. Histone deacetylase inhibitors
WO2007095584A2 (en) 2006-02-14 2007-08-23 The President And Fellows Of Harvard College Histone Deacetylase Inhibitors
US9724321B2 (en) 2006-02-14 2017-08-08 President & Fellows Of Harvard College Histone deacetylase inhibitors
US8067025B2 (en) 2006-02-17 2011-11-29 Advanced Cardiovascular Systems, Inc. Nitric oxide generating medical devices
US8821561B2 (en) 2006-02-22 2014-09-02 Boston Scientific Scimed, Inc. Marker arrangement for bifurcation catheter
US7713637B2 (en) 2006-03-03 2010-05-11 Advanced Cardiovascular Systems, Inc. Coating containing PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid polymer
EP1832301A3 (en) * 2006-03-08 2007-12-05 Sahajanand Medical Technologies PVT. ltd Coatings for implantable medical devices
EP1832301A2 (en) * 2006-03-08 2007-09-12 Sahajanand Medical Technologies PVT. ltd Coatings for implantable medical devices
US8574615B2 (en) 2006-03-24 2013-11-05 Boston Scientific Scimed, Inc. Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
EP2019657A4 (en) * 2006-04-26 2012-10-03 Micell Technologies Inc Coatings containing multiple drugs
EP2019657A2 (en) * 2006-04-26 2009-02-04 Micell Technologies, Inc. Coatings containing multiple drugs
US9415142B2 (en) 2006-04-26 2016-08-16 Micell Technologies, Inc. Coatings containing multiple drugs
US8852625B2 (en) 2006-04-26 2014-10-07 Micell Technologies, Inc. Coatings containing multiple drugs
US9737645B2 (en) 2006-04-26 2017-08-22 Micell Technologies, Inc. Coatings containing multiple drugs
WO2007130429A2 (en) 2006-05-03 2007-11-15 The President And Fellows Of Harvard College Histone deacetylase and tubulin deacetylase inhibitors
US8304451B2 (en) 2006-05-03 2012-11-06 President And Fellows Of Harvard College Histone deacetylase and tubulin deacetylase inhibitors
US20090209590A1 (en) * 2006-05-03 2009-08-20 Ralph Mazitschek Histone Deacetylase and Tubulin Deacetylase Inhibitors
US8741379B2 (en) 2006-05-04 2014-06-03 Advanced Cardiovascular Systems, Inc. Rotatable support elements for stents
US8637110B2 (en) 2006-05-04 2014-01-28 Advanced Cardiovascular Systems, Inc. Rotatable support elements for stents
US7985441B1 (en) 2006-05-04 2011-07-26 Yiwen Tang Purification of polymers for coating applications
US8465789B2 (en) 2006-05-04 2013-06-18 Advanced Cardiovascular Systems, Inc. Rotatable support elements for stents
US8069814B2 (en) 2006-05-04 2011-12-06 Advanced Cardiovascular Systems, Inc. Stent support devices
US8003156B2 (en) 2006-05-04 2011-08-23 Advanced Cardiovascular Systems, Inc. Rotatable support elements for stents
US8304012B2 (en) 2006-05-04 2012-11-06 Advanced Cardiovascular Systems, Inc. Method for drying a stent
US8596215B2 (en) 2006-05-04 2013-12-03 Advanced Cardiovascular Systems, Inc. Rotatable support elements for stents
US8616152B2 (en) * 2006-05-26 2013-12-31 Abbott Cardiovascular Systems Inc. Stent coating apparatus
US7775178B2 (en) 2006-05-26 2010-08-17 Advanced Cardiovascular Systems, Inc. Stent coating apparatus and method
US20120291703A1 (en) * 2006-05-26 2012-11-22 Advanced Cardiovascular Systems, Inc. Stent coating apparatus
US9561351B2 (en) 2006-05-31 2017-02-07 Advanced Cardiovascular Systems, Inc. Drug delivery spiral coil construct
US8568764B2 (en) 2006-05-31 2013-10-29 Advanced Cardiovascular Systems, Inc. Methods of forming coating layers for medical devices utilizing flash vaporization
US7820172B1 (en) 2006-06-01 2010-10-26 Biosurface Engineering Technologies, Inc. Laminin-derived multi-domain peptides
US8703167B2 (en) 2006-06-05 2014-04-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug
US8029816B2 (en) 2006-06-09 2011-10-04 Abbott Cardiovascular Systems Inc. Medical device coated with a coating containing elastin pentapeptide VGVPG
US8778376B2 (en) 2006-06-09 2014-07-15 Advanced Cardiovascular Systems, Inc. Copolymer comprising elastin pentapeptide block and hydrophilic block, and medical device and method of treating
US8118863B2 (en) 2006-06-14 2012-02-21 Abbott Cardiovascular Systems Inc. RGD peptide attached to bioabsorbable stents
US8062350B2 (en) 2006-06-14 2011-11-22 Abbott Cardiovascular Systems Inc. RGD peptide attached to bioabsorbable stents
US8808342B2 (en) 2006-06-14 2014-08-19 Abbott Cardiovascular Systems Inc. Nanoshell therapy
US8603530B2 (en) 2006-06-14 2013-12-10 Abbott Cardiovascular Systems Inc. Nanoshell therapy
US8114150B2 (en) 2006-06-14 2012-02-14 Advanced Cardiovascular Systems, Inc. RGD peptide attached to bioabsorbable stents
US8048448B2 (en) 2006-06-15 2011-11-01 Abbott Cardiovascular Systems Inc. Nanoshells for drug delivery
US20080160169A1 (en) * 2006-06-22 2008-07-03 Zamora Paul O Coating device and method for coating medical device with bioactive peptide
US8592036B2 (en) 2006-06-23 2013-11-26 Abbott Cardiovascular Systems Inc. Nanoshells on polymers
US8017237B2 (en) 2006-06-23 2011-09-13 Abbott Cardiovascular Systems, Inc. Nanoshells on polymers
US8293367B2 (en) 2006-06-23 2012-10-23 Advanced Cardiovascular Systems, Inc. Nanoshells on polymers
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
US8771343B2 (en) 2006-06-29 2014-07-08 Boston Scientific Scimed, Inc. Medical devices with selective titanium oxide coatings
WO2008005284A3 (en) * 2006-06-30 2009-01-29 Cook Inc Methods of manufacturing and modifying taxane coatings for implantable medical devices
US9028859B2 (en) 2006-07-07 2015-05-12 Advanced Cardiovascular Systems, Inc. Phase-separated block copolymer coatings for implantable medical devices
US8685430B1 (en) 2006-07-14 2014-04-01 Abbott Cardiovascular Systems Inc. Tailored aliphatic polyesters for stent coatings
US8703169B1 (en) 2006-08-15 2014-04-22 Abbott Cardiovascular Systems Inc. Implantable device having a coating comprising carrageenan and a biostable polymer
CN100569302C (en) 2006-08-25 2009-12-16 许川山 Photo-sensitive stent with restricture-proof function
US8353949B2 (en) 2006-09-14 2013-01-15 Boston Scientific Scimed, Inc. Medical devices with drug-eluting coating
US20080097568A1 (en) * 2006-10-20 2008-04-24 Savage Douglas R Drug-delivery endovascular stent and method of use
US20080097591A1 (en) * 2006-10-20 2008-04-24 Biosensors International Group Drug-delivery endovascular stent and method of use
US8067055B2 (en) 2006-10-20 2011-11-29 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method of use
US9579424B2 (en) 2006-10-20 2017-02-28 Biosensors International Group, Ltd. Drug delivery endovascular stent and method of use
US9539593B2 (en) 2006-10-23 2017-01-10 Micell Technologies, Inc. Holder for electrically charging a substrate during coating
EP2559408A2 (en) 2006-10-25 2013-02-20 Biosensors International Group, Ltd. Temporary intraluminal stent and methods of manufacture and use.
US20080103584A1 (en) * 2006-10-25 2008-05-01 Biosensors International Group Temporal Intraluminal Stent, Methods of Making and Using
US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
US8597673B2 (en) 2006-12-13 2013-12-03 Advanced Cardiovascular Systems, Inc. Coating of fast absorption or dissolution
US20080142616A1 (en) * 2006-12-15 2008-06-19 Bacoustics Llc Method of Producing a Directed Spray
US20100063580A1 (en) * 2007-01-08 2010-03-11 Mcclain James B Stents having biodegradable layers
US9737642B2 (en) 2007-01-08 2017-08-22 Micell Technologies, Inc. Stents having biodegradable layers
US20110210121A1 (en) * 2007-02-13 2011-09-01 Gateway Plastics, Inc. Container system
EP1961401A2 (en) 2007-02-20 2008-08-27 Cardiatis Société Anonyme Hyperplasia plaque-preventing stent
US20080208313A1 (en) * 2007-02-26 2008-08-28 Medtronic Vascular, Inc. Drug Coated Stent With Magnesium Topcoat
US8273402B2 (en) 2007-02-26 2012-09-25 Medtronic Vascular, Inc. Drug coated stent with magnesium topcoat
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
EP1977772A2 (en) 2007-03-28 2008-10-08 Cordis Corporation Short term sustained drug-delivery system for implantable medical devices and method of making the same
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US9433516B2 (en) 2007-04-17 2016-09-06 Micell Technologies, Inc. Stents having controlled elution
US9775729B2 (en) 2007-04-17 2017-10-03 Micell Technologies, Inc. Stents having controlled elution
US9486338B2 (en) 2007-04-17 2016-11-08 Micell Technologies, Inc. Stents having controlled elution
GB2448871A (en) * 2007-04-30 2008-11-05 Inion Ltd Modulation of inflammatory and immune responses in the treatment of inflammation using substituted heterocyclic compounds
US8147769B1 (en) 2007-05-16 2012-04-03 Abbott Cardiovascular Systems Inc. Stent and delivery system with reduced chemical degradation
US9320627B2 (en) 2007-05-23 2016-04-26 Abbott Laboratories Vascular Enterprises Limited Flexible stent with torque-absorbing connectors
US8016874B2 (en) 2007-05-23 2011-09-13 Abbott Laboratories Vascular Enterprises Limited Flexible stent with elevated scaffolding properties
US20080294240A1 (en) * 2007-05-23 2008-11-27 Abbott Laboratories Vascular Enterprises Limited Flexible stent with torque-absorbing connectors
US8128679B2 (en) 2007-05-23 2012-03-06 Abbott Laboratories Vascular Enterprises Limited Flexible stent with torque-absorbing connectors
US7976915B2 (en) 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US8900651B2 (en) 2007-05-25 2014-12-02 Micell Technologies, Inc. Polymer films for medical device coating
US9056155B1 (en) 2007-05-29 2015-06-16 Abbott Cardiovascular Systems Inc. Coatings having an elastic primer layer
KR100888219B1 (en) 2007-06-01 2009-03-12 (주) 태웅메디칼 Coating agent for drug releasing stent, manufacturing method thereof and drug releasing stent coated with the coating agent
US8109904B1 (en) 2007-06-25 2012-02-07 Abbott Cardiovascular Systems Inc. Drug delivery medical devices
US8048441B2 (en) 2007-06-25 2011-11-01 Abbott Cardiovascular Systems, Inc. Nanobead releasing medical devices
US8002823B2 (en) 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7753285B2 (en) 2007-07-13 2010-07-13 Bacoustics, Llc Echoing ultrasound atomization and/or mixing system
US7780095B2 (en) 2007-07-13 2010-08-24 Bacoustics, Llc Ultrasound pumping apparatus
US9284409B2 (en) 2007-07-19 2016-03-15 Boston Scientific Scimed, Inc. Endoprosthesis having a non-fouling surface
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US8221822B2 (en) 2007-07-31 2012-07-17 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
US8900292B2 (en) 2007-08-03 2014-12-02 Boston Scientific Scimed, Inc. Coating for medical device having increased surface area
US20090073577A1 (en) * 2007-09-19 2009-03-19 Samsung Electro-Mechanics Co., Ltd. Super wide angle optical system
US20090118820A1 (en) * 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20090118818A1 (en) * 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis with coating
US8029554B2 (en) 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US8936567B2 (en) 2007-11-14 2015-01-20 Boston Scientific Scimed, Inc. Balloon bifurcated lumen treatment
US8246674B2 (en) 2007-12-20 2012-08-21 Abbott Laboratories Vascular Enterprises Limited Endoprosthesis having struts linked by foot extensions
US20090163992A1 (en) * 2007-12-20 2009-06-25 Abbott Laboratories Vascular Enterprises Limited Endoprosthesis having flexible connectors
US20110144738A1 (en) * 2007-12-20 2011-06-16 Abbott Laboratories Vascular Enterprises, Ltd. Endoprosthesis having struts linked by foot extensions
US7850726B2 (en) 2007-12-20 2010-12-14 Abbott Laboratories Vascular Enterprises Limited Endoprosthesis having struts linked by foot extensions
US8337544B2 (en) 2007-12-20 2012-12-25 Abbott Laboratories Vascular Enterprises Limited Endoprosthesis having flexible connectors
US8920488B2 (en) 2007-12-20 2014-12-30 Abbott Laboratories Vascular Enterprises Limited Endoprosthesis having a stable architecture
US8747456B2 (en) 2007-12-31 2014-06-10 Boston Scientific Scimed, Inc. Bifurcation stent delivery system and methods
US9789233B2 (en) 2008-04-17 2017-10-17 Micell Technologies, Inc. Stents having bioabsorbable layers
US8920491B2 (en) 2008-04-22 2014-12-30 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
US8932346B2 (en) 2008-04-24 2015-01-13 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
US8042251B2 (en) 2008-05-21 2011-10-25 Boston Scientific Scimed, Inc. Systems and methods for heating and cooling during stent crimping
US20090292347A1 (en) * 2008-05-21 2009-11-26 Boston Scientific Scimed, Inc. Systems and methods for heating and cooling during stent crimping
US8377108B2 (en) 2008-06-02 2013-02-19 Boston Scientific Scimed, Inc. Staggered two balloon bifurcation catheter assembly and methods
US8827954B2 (en) 2008-06-05 2014-09-09 Boston Scientific Scimed, Inc. Deflatable bifurcated device
US8449603B2 (en) 2008-06-18 2013-05-28 Boston Scientific Scimed, Inc. Endoprosthesis coating
US9510856B2 (en) 2008-07-17 2016-12-06 Micell Technologies, Inc. Drug delivery medical device
US9486431B2 (en) 2008-07-17 2016-11-08 Micell Technologies, Inc. Drug delivery medical device
US20100016890A1 (en) * 2008-07-17 2010-01-21 Steve Tsai Spool Dip And Overcoat Process For Medical Devices
US9434686B2 (en) 2008-07-23 2016-09-06 President And Fellows Of Harvard College Deacetylase inhibitors and uses thereof
US8440716B2 (en) 2008-07-23 2013-05-14 President And Fellows Of Harvard College Deacetylase inhibitors and uses thereof
US20110172303A1 (en) * 2008-07-23 2011-07-14 Dana-Farber Cancer Institute, Inc. Deacetylase inhibitors and uses thereof
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
US8834913B2 (en) 2008-12-26 2014-09-16 Battelle Memorial Institute Medical implants and methods of making medical implants
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
WO2010140869A2 (en) * 2009-06-05 2010-12-09 Iljin Copper Foil Co., Ltd. Complex, multilayer using the same, and device coated with the multilayer
WO2010140869A3 (en) * 2009-06-05 2011-04-28 Iljin Copper Foil Co., Ltd. Complex, multilayer using the same, and device coated with the multilayer
WO2011003095A1 (en) 2009-07-02 2011-01-06 Tryton Medical, Inc. Ostium support for treating vascular bifurcations
US8716344B2 (en) 2009-08-11 2014-05-06 President And Fellows Of Harvard College Class- and isoform-specific HDAC inhibitors and uses thereof
US9540317B2 (en) 2009-08-11 2017-01-10 President And Fellows Of Harvard College Class- and isoform-specific HDAC inhibitors and uses thereof
WO2011061295A1 (en) 2009-11-19 2011-05-26 Blue Medical Devices Bv Narrow profile composition-releasing expandable medical balloon catheter
EP3091004A1 (en) 2010-01-22 2016-11-09 Acetylon Pharmaceuticals, Inc. Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof
US20110190864A1 (en) * 2010-02-02 2011-08-04 Micell Technologies, Inc. Stent and stent delivery system with improved deliverability
WO2011119883A1 (en) 2010-03-24 2011-09-29 Advanced Bifurcation Systems, Inc. Stent alignment during treatment of a bifurcation
US9687864B2 (en) 2010-03-26 2017-06-27 Battelle Memorial Institute System and method for enhanced electrostatic deposition and surface coatings
US8795762B2 (en) 2010-03-26 2014-08-05 Battelle Memorial Institute System and method for enhanced electrostatic deposition and surface coatings
US8389041B2 (en) 2010-06-17 2013-03-05 Abbott Cardiovascular Systems, Inc. Systems and methods for rotating and coating an implantable device
US8632841B2 (en) 2010-06-17 2014-01-21 Abbott Cardiovascular Systems, Inc. Systems and methods for rotating and coating an implantable device
EP3067346A1 (en) 2010-11-16 2016-09-14 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof
WO2012068109A2 (en) 2010-11-16 2012-05-24 Acetylon Pharmaceuticals Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof
WO2012109365A1 (en) 2011-02-08 2012-08-16 Advanced Bifurcation Systems, Inc. System and methods for treating a bifurcation with a fully crimped stent
US9388127B2 (en) 2012-04-17 2016-07-12 University College Dublin, National University Of Ireland, Dublin Thromboxane receptor antagonists
US20160102051A1 (en) * 2012-04-17 2016-04-14 University College Dublin, National University Of Ireland, Dublin Methods and compounds for treating proliferative disorders and viral infections
US9522877B2 (en) 2012-04-17 2016-12-20 University College Dublin, National University Of Ireland, Dublin Thromboxane receptor antagonists
WO2013156871A3 (en) * 2012-04-17 2014-06-26 University College Dublin, National University Of Ireland, Dublin Thromboxane receptor antagonists
US9738599B2 (en) 2012-04-17 2017-08-22 University College Dublin, National University Of Ireland, Dublin Thromboxane receptor antagonists
US9718781B2 (en) * 2012-04-17 2017-08-01 University College Dublin, National University Of Ireland, Dublin Methods and compounds for treating proliferative disorders and viral infections
WO2014047328A2 (en) 2012-09-19 2014-03-27 Faller Douglas V Pkc delta inhibitors for use as therapeutics
US9730638B2 (en) 2013-03-13 2017-08-15 Glaukos Corporation Intraocular physiological sensor
WO2016105518A1 (en) 2014-12-23 2016-06-30 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
WO2017024317A2 (en) 2015-08-06 2017-02-09 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
US9932304B2 (en) 2016-06-13 2018-04-03 University College Dublin, National University Of Ireland, Dublin Thromboxane receptor antagonists

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