Connect public, paid and private patent data with Google Patents Public Datasets

Catheter with simultaneous brush cytology and scrape biopsy capability

Download PDF

Info

Publication number
US5535756A
US5535756A US08178112 US17811294A US5535756A US 5535756 A US5535756 A US 5535756A US 08178112 US08178112 US 08178112 US 17811294 A US17811294 A US 17811294A US 5535756 A US5535756 A US 5535756A
Authority
US
Grant status
Grant
Patent type
Prior art keywords
brush
duct
catheter
bristles
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
US08178112
Inventor
Vinod K. Parasher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cook Medical Technologies LLC
Original Assignee
Parasher; Vinod K.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • A61B2010/0216Sampling brushes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22038Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with a guide wire
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32Surgical cutting instruments
    • A61B2017/320004Surgical cutting instruments abrasive
    • A61B2017/320008Scrapers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32Surgical cutting instruments
    • A61B2017/320004Surgical cutting instruments abrasive
    • A61B2017/320012Brushes

Abstract

A medical device performs simultaneous brush cytology and scrape biopsy on structures within an organic duct by collecting cells and tissue on a brush having irregular semi-rigid bristles, preferably formed as the hook portion of a hook and pile fastener (e.g., the hook portion of a Velcro pad). A wire guided catheter has a brush strip located near a distal end for insertion into the duct. Once the distal end and brush are positioned at a selected location within the duct, the catheter is pushed and pulled back and forth to gather cells and scrapings from the selected location, which accumulate in the irregular bristles. The catheter can be enclosed in a retractable sleeve during insertion and/or withdrawal. An enlargement at the distal end of the catheter assists in opening the duct to admit the brush. A radio-opaque marker is externally detectable to assist in locating the brush at the selected location. The relatively stiff irregular bristles improve the extent to which cells and tissues can be collected and permit collection of enough tissue to provide a biopsy sample, without substantial risk of perforation of the duct.

Description

BACKGROUND OF THE INVENTION

1. Field of the Invention

This invention relates to devices for collecting cell samples from internal organs, and in particular to a catheter capable of simultaneously performing brush cytology and scrape biopsies of structures within biological ducts, employing a polymeric hook pad with relatively stiff irregularly shaped bristles for collecting cells from a sample site. More particularly, a wire guided catheter having a hook pad of a hook and pile fastener (e.g., Velcro) at its distal end is used for abrading against the duct walls to collect cells and tissue.

2. Description of the Prior Art

It is sometimes necessary to collect a sampling of cells from internal organs, typically using an endoscope or laparoscope to obtain access to the site to be sampled, for laboratory analysis in connection with a diagnosis. In connection with certain bodily ducts, a tumor in the tissue of the duct or in tissues adjacent the duct may present as a narrowing or stricture of the duct at a localized area. Cancer of the bile duct or the pancreatic ducts, for example, present as a narrowing or stricture. Similarly, strictures can be seen in the esophagus, the stomach, the colon, and other duct-like organs. It is useful in connection with diagnosis to examine the cells at a stricture to better assess its cause.

Known cytological techniques for collection of cell samples at duct strictures and other sites have a number of shortcomings. The diagnosis of pancreato-biliary malignancy is an example. Normally, an endoscope is used to obtain access to the collection site, for example the pancreatic duct leading from the pancreas to the duodenum. A cell collection tool that is basically an elongated brush usually having soft bristles set in twisted strands of wire is passed through the endoscope. Using the wire to pull the brush in opposite directions, the bristles are brushed over the inner wall of the duct at the stricture, in an effort to displace cells from the duct wall and capture the cells in the bristles. This technique is sometimes called "brush cytology" or just "cytology."

The brush can be placed in a sleeve to assist in guidance to the sample site, to avoid picking up cells from areas other than the stricture, and to protect the sample after it is collected. The sleeve can have one or more radio-opaque marks to help in placing the brush at the stricture. More particularly, fluoroscopy is used to visualize the location of the sleeve by the radio-opaque mark and therefore to assist in placing the brush in the stricture.

Unfortunately, brush cytology as described is only adequate to collect sufficient cells to effect diagnosis in about 18 to 70% of attempts. The technique offers no biopsy capability because it cannot effectively extract a gross tissue sample from the area of the stricture. Diagnosis of a potential malignancy, however, certainly requires dependable results in the collection of cells, and may require collection of a more extensive biopsy sample. To diagnose a malignancy associated with a stricture, for example, it may be appropriate to examine the mucous lining of the duct, the tissue of the duct wall and even adjacent tissues. The known brush cannot extract sufficient cells and tissue in a dependable manner. The known wire-carried brush can be reciprocated using the wire but it is not guided by the wire. Accordingly, the known brush is difficult to use effectively in difficult to reach, narrow areas of the ducts. Presently, a biopsy of the area of the stricture is obtained by passing a different instrument, typically a biopsy forceps, through the endoscope and then cutting away and removing a relatively large chunk of the tissue from the diseased area. However, use of biopsy forceps involves an inherent risk of perforating the duct, and for this reason their use is not preferred.

SUMMARY OF THE INVENTION

It is an object of the invention to provide a method and apparatus that can better collect a tissue sample from a stricture in a duct or from another anatomical structure, preferably that can obtain a sufficient sampling of cells to assist in diagnosis more dependably. More particularly, there is a need to enable collection of a sample sufficient to qualify as a biopsy, but in a manner that reduces the risk of perforating the duct as compared with known techniques.

It would be advantageous therefore to provide an instrument that is capable of obtaining a brush cytology sample that can also be used to obtain a larger tissue sample for a biopsy, preferably enabling selection of a brush sample more dependably, and enabling collection of a gross tissue sample or biopsy, using the same tool and substantially via the same procedure. Such an instrument would be particularly useful in the diagnosis of anomalies of the pancreato-biliary structures, such as a malignancy presented as a stricture of the ducts.

These and other objects are met according to the invention in a device capable of performing a brushing of tissue at a stricture in a duct for collecting cells (cytology) and also capable of obtaining a greater sample of the tissue (biopsy) at the stricture in a procedure that combines cytology and biopsy. The duct can be, for example, the common bile duct, the pancreatic duct, and any of a number of other duct-like organs and the like, such as, for example, the esophagus, the stomach, the large bowel, the lungs, the uterus, the ureter, the kidney, etc., all such organs being collectively referred to herein as ducts.

The device includes an elongated, flexible catheter and a brush made of semi-rigid bristles with irregular shapes for capturing cells and tissue in the bristles, preferably bristles on a pad or fabric of the type conventionally used as the hook side of hook and pile fasteners such as Velcro. The brush is located adjacent a distal end of the catheter. The catheter is inserted into the duct or duct-like organ, and can be passed over a guide wire for guiding the catheter into and through the duct.

According to another aspect of the invention, the bristles of the brush provide an inherent structure for capturing and then protecting the collected cells. Accordingly, the individual bristles can include hooks, ball-shaped, looped, mushroom-shaped or T-shaped structures at their ends, tending to collect cells and tissue and to retain the collected material during withdrawal of the device. The hooks can be separately formed or provided as cut loops, or formed in another manner known in connection with use of the bristles as fastener elements.

According to another aspect, the distal end of the catheter that is inserted into the duct can be ball-tipped with a radio-opaque ball, or structured for expanding the duct to allow the brush to pass through the duct as the bristles work on the inner wall of the duct.

The catheter can include a marking device located adjacent to the brush, such as a radio-opaque mark, to assist in guiding the catheter to a desired location in the duct, as viewed fluoroscopically. Additionally, a retractable sleeve can be provided to encompass the brush during passage of the catheter to a selected location in the duct, and/or to protect the collected sample when being removed on the brush.

The invention includes a method for performing combined cytology and biopsy in a duct using a wire-guided catheter as described. The brush near the distal end of the catheter that is to be inserted into the duct is fabricated of semi-rigid irregularly shaped bristles, e.g., hooked or blunt ended bristles or the like, for example the bristles of a hook pad material such as Velcro. The method includes the steps of first performing endoscopy to obtain access to an opening into the respective duct. For example, in a bile duct or a pancreatic procedure, an endoscopic retrograde cholangio pancreatography (ERCP) is performed. The endoscope can be brought near to the site of to be sampled, such as a stricture, if this is convenient. A blunt-ended guide wire is moved into the duct so as to pass a selected area of the duct at which the cytology is to be performed and/or a biopsy sample taken. The distal end of the catheter, including the brush, is then inserted over the guide wire into the duct, i.e., with the wire passing through the lumen of the catheter. The brush bearing end of the catheter is moved to the selected area of the duct and pushed and pulled, back and forth over the inner wall of the duct. The bristles of the brush collect sample scrapings of tissue and brushings of cells at the selected area. The end of the catheter with the brush is withdrawn from the duct through the endoscope or into a sleeve provided to protect the sample. The scrapings of tissue and cells that cling to the brush can then be removed and analyzed by standard methods.

According to a further aspect of the invention, the catheter can include markers, such as radio-opaque markers, located near the brush and for example straddling the brush along the longitudinal axis of the catheter, for assisting in guiding the brush to the selected area. According to another aspect of the invention, the first end of the catheter includes an expansion mechanism for expanding the duct. The method includes the further step of expanding a section of the duct with the expansion mechanism before passing the brush into the selected area. This can be especially useful in the case where the selected area has a very narrow stricture.

According to another aspect of the invention, a longitudinally retractable sheath, or sleeve made of nylon, polyethylene, polyurethane, polytetrafluoroethylene (Teflon) or the like, covers the brush as it is guided to the selected area. The sheath is retractable in a telescoping manner to expose the brush at the selected area before the brush is pushed and pulled over the tissues, and after brushing the sleeve can be moved back over the brush, or the brush can be withdrawn into the sleeve. Thus the brush can be deployed internally, used and then protected against loss or contamination of the sample, before removing the brush from the duct.

The catheter and the brush thereon can be withdrawn along the guide wire. After removing the catheter from the duct, a stent can be passed over the guide wire in place of the catheter, for keeping the duct open through the area of the stricture. The guide wire can then be withdrawn.

Cytology can be rendered more effective according to the invention because a more substantial sample can be taken than with the brush apparatus conventionally known. The brush can be operated more gently for collection of cells or more vigorously to obtain pieces of tissue for biopsy analysis. Nevertheless, the brushing procedure is safer than surgical extraction of tissue from the wall of the duct.

These and other objects of the invention will be more fully understood from the following description of the invention with reference to the accompanying drawings.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a partial elevation view of a first embodiment of the device of this invention.

FIG. 2 is a partial elevation view of a second embodiment of the device of this invention.

FIG. 3 is a partial elevation view of a third embodiment of the device of this invention, including a retractable sleeve that can be positioned over the bristles of the brush.

FIG. 4a-4c are elevational views of three preferred embodiments of bristle designs for the brush.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

A first embodiment of a device 1 according to the invention is illustrated in FIGURE. 1. Device 1 includes a flexible, hollow tube 3, or catheter, having a ball tip 5, for example of metal. Similar structures of the respective embodiments will be referenced by the same reference numbers throughout this specification for simplicity of exposition. For applications such as taking simultaneous brushings and biopsies of structures in the common bile duct and the pancreatic duct, tube 3 can be, for example, 2 m long and 0.2 cm in internal diameter, such as a No. 6 French nylon catheter, or larger or smaller, as required.

A blunt ended guide wire 7 is placed in the duct to be examined, such that the wire extends beyond the stricture or other site to be sampled. Guide wire 7 can be, for example, a 0.035 inch (0.09 cm) diameter, blunt-ended guide wire, preferably made of a resilient metal, such as steel or titanium coated with an outer layer of a material that is nonreactive, such as polytetrafluoroethylene (Teflon). A metal ball tip 5 on the catheter can be provided both to push aside duct tissues without puncturing them and to provide a radio-opaque structure that can be used to locate the end of the catheter, by fluoroscopy. Alternatively, the tip 5 can be a relatively wider loop end. The catheter is slid over the guide wire to the sampling site.

Catheter 3 comprises a brush 9, preferably arranged around the catheter adjacent the distal end, but also potentially along one lateral side only. Brush 9 comprises a plurality of radially extending, semi-rigid bristles 11 that protrude from a base strip that is attached adhesively to catheter 3 near the distal end. Individual bristles 11 have enlarged or hooked ends, which in a hook and pile fastener is a means by which the ends engage a pile. However, according to the invention, the relatively stiff bristles and their enlarged or hooked ends readily collect cell and tissue samples and provide a zone radially inwardly of the enlarged or hooked ends where the sampled cells and tissue tend to become trapped.

The brush 9 can be made using the hooked side of a Velcro or other hook and pile type fastener, for example with bristles extending radially about 1 to 3 mm. The length of the brush 9 along the longitudinal length of catheter 3 can vary depending upon the application, but preferably is at least 0.5 cm long. For most applications, it need not be more than about 1.5 cm in length, however, longer length brushes are also included within the scope of this invention, and can be used when it is desirable to collect and perhaps to distinguish among cells and tissue collected over a predetermined length of the duct.

Fastener pads as described generally comprise bristles formed on a base web of plastic or the like. The bristle ends can be formed in a number of ways, such as by melting the ends of standing thermoplastic bristles to provide a ball or mushroom shape or to cause the ends to bend rearwardly, forming hooks. Another technique is to form a loop pile and to cut the loops to provide a hooked bristle and a straight bristle. All such alternatives produce irregular bristles useful for collecting cells and tissue. Other forms of the grasping part of pad fastener materials can be used as well. Preferably, the brush or bristle pad is attached by the base of the pad to the catheter. The base can be attached by adhesive, heat welding or the like to provide a secure connection. The bristle bearing pad can extend part way around the circumference of the catheter, but preferably extends substantially around a full 360°.

Referring to FIG. 2, an alternative embodiment of the device includes markers 13, such as metal bands or clips, on one or both longitudinal sides of brush 9 for locating the distal end of the catheter and the brush while in the duct. Markers 13 are visible by fluoroscopy. The embodiment of FIG. 2 also includes a means for dilating the duct with longitudinal advance of catheter 3, for assisting passage through the duct of brush 9. Brush 9 is slightly wider than the portion of catheter 3 where brush 9 is mounted within the duct. The distal end of the catheter 3 as shown has an enlarged, preferably cone-shaped structure 15 in this embodiment to mechanically dilate the duct as the distal end is inserted. Other means, such as inflatable balloon catheter means, can be used as another way to dilate the duct.

Preferably, the device is used with a retractable sheath or sleeve 17, that can be moved longitudinally relative to catheter 3, in particular in both directions between a position covering the brush (as in FIG. 2) and a retracted position exposing the brush (as in FIG. 3). The sleeve 17 likewise can be fabricated of nylon, polyethylene, Teflon or the like. Sleeve 17 just fits over catheter 3, and is effective to prevent brush 9 from picking up cell or tissue samples before being deployed in place at the sample site, and to prevent contact between brush 9 and the duct after the sample is collected, which contact could cause captured cells and tissue to come free of brush 9 or additional cells or tissue to be picked up from other sites.

FIGS. 4a-4c illustrate different preferred embodiments for bristles 11 of brush 9. In FIG. 4a bristles 11 have a ball-tip or mushroom tip structure 19 located at the distal end of each bristle 11. Bristles 11 in FIG. 4b have hooks 21 at their ends. FIG. 4c illustrates bristles 11 forming closed loops 23. It is to be understood that although three specific embodiments of bristle designs are described herein, this is not meant to be limiting. Other bristle designs having similar characteristics, and in particular that have a structure effective for capturing and holding cells and tissue, are also encompassed within the scope of the invention.

The device of this invention is used in the following manner in performing a combination of cytology and biopsy of a stricture in a pancreatic duct, for example. An ERCP is performed to gain entry to the duct. The guide wire 7 is then passed into the duct sufficiently to approach or preferably pass a selected area of the duct at which the cytology/biopsy is to be performed. The distal end of catheter 3, including brush 9, is inserted over guide wire 7 into the duct. The position is monitored by viewing the ball-tip 5 or other radiographic marker, such as clips 13, with a fluoroscope. Brush 9 is moved to the selected area of the duct. If the duct stricture is very narrow, a catheter having a mechanism for expanding the duct, such as a cone-shaped end 15, can be used to dilate the duct before entry of the brush 9 into the stricture. The brush 9 on catheter 3 is exposed by retracting the sheath or sleeve 17. Catheter 3 then is pushed and pulled, back and forth, several times such that sample scrapings of tissue and brushings of cells from the stricture cling to bristles 11 of brush 9, more particularly being captured by the bristle structures. Catheter 3 is then retracted into sleeve 17 (or sleeve 17 is advanced) sufficiently to protect brush 9. The catheter is withdrawn from the duct together with sleeve 17, through the endoscope. Guide wire 7 can be withdrawn simultaneously or afterwards.

The scrapings of tissue and cells that cling to bristles 11 of brush 9 can be removed and analyzed for abnormalities according to methods known in the art. Prior to retracting guide wire 7, a stent or tube, also known in the art, can be passed over the guide wire 7 after removal of the catheter 3 and left in the stricture to keep the duct unblocked.

Whereas particular embodiments of the present invention have been described above for purposes of illustration, it will be appreciated by those skilled in the art that numerous variations of the details may be made without departing from the invention as described in the appended claims.

Claims (15)

I claim:
1. A device for collecting cells from a duct, comprising:
a catheter forming a hollow tube with a brush located close to a distal end of the catheter, for insertion into the duct, wherein the brush is fabricated of semi-rigid bristles protruding radially from the tube, the bristles having irregular shaped tips whereby the cells are collected in the bristles by scraping the brush over an inner wall of the duct;
an enlargement formed in the catheter adjoining the distal end of the catheter;
wherein the enlargement occupies a position separating the brush from the distal end, and is shaped and arranged for expanding the duct to permit passage of the brush during insertion through the duct and for expanding the duct during withdrawal to permit withdrawing from the duct scraped and collected cells; and,
a sleeve movably disposed on the catheter to cover and uncover the brush;
wherein the sleeve is formed to be abuttable against the enlargement of the catheter for protecting the scraped cells collected on the brush during withdrawal of the catheter and sleeve combination from the duct.
2. The device of claim 1, wherein the bristles have hooked distal ends.
3. The device of claim 2, wherein the bristles are provided on a pad of hook material of a hook and pile fastener.
4. The device of claim 1, wherein the brush is formed of a pad carrying the bristles and extends along the catheter longitudinally by about 0.5 to 1.5 cm.
5. The device of claim 4, wherein the pad extends substantially fully around a circumference of the catheter.
6. The device of claim 1, further comprising at least one marker means detectable externally of the duct, located adjacent the brush for guiding the brush to a selected location in the duct using an external means for detecting the marker.
7. The device of claim 6, wherein the marker means comprises a radio-opaque marker.
8. The device of claim 6, wherein the marker means comprises a pair of radio-opaque markers located adjacent the brush on opposite sides.
9. The device of claim 8, further comprising guide means for guiding the brush to a desired location by sliding the catheter over the guide means.
10. The device of claim 9, wherein the guide means comprises a guide wire longitudinally extending inside the catheter and having a blunt end extending beyond the distal end of the catheter.
11. The device of claim 1, further comprises a flexible material selected from the group consisting of nylon, polyethylene, polyurethane and polytetrafluoroethylene.
12. A device for performing simultaneous cytology and obtaining a scrape biopsy of tissue and cells at a stricture in a duct, comprising:
a flexible hollow catheter having a distal end for insertion into the duct and capable of being fed into the duct over a guide wire extending through the catheter to pass through the stricture, the catheter having an enlargement terminating at the distal end for expanding the duct;
a brush having semirigid bristles protruding substantially radially from the catheter and formed over a longitudinal distance adjacent the enlargement, the enlargement occupying an intermediate position between the brush and the distal end, the bristles being irregularly shaped bristles of a grasping portion of pad fastener material, disposed substantially around a full circumference of the catheter;
radio-opaque marker means near the brush for locating the brush by fluoroscopy;
a retractable sleeve movable between a covering position surrounding the brush and a retracted position exposing the brush;
wherein the sleeve is formed and arranged to be abuttable against the enlargement of the catheter for protecting the scraped cells collected on the brush during withdrawal of the catheter and sleeve combination from the duct.
13. A method for collecting cells and tissue from a selected area within a duct, comprising:
placing a guide wire in the duct such that the guide wire passes the selected area;
supplying a catheter, which catheter has a distal end, an enlargement terminating in the distal end, and a brush adjacent the enlargement, the enlargement occupying an intermediate position between the brush and the distal end;
inserting the catheter into the duct over the guide wire, the brush with semirigid bristles extending from the catheter, the bristles being irregularly shaped bristles of a hook portion of a hook and pile fastener, operable to capture the cells and tissue;
enlarging the duct to admit the brush by the enlargement of the catheter at the distal end of the catheter;
advancing the catheter to position the brush at the selected area;
alternately pushing and pulling the brush back and forth at the selected area, whereupon the cells and tissue accumulate in the bristles in the wake of the enlargement when the catheter is pushed; and,
withdrawing the catheter and the brush from the duct wherein cells and tissues collected by brush are partly pushed by the enlargement.
14. The method of claim 13, further comprising enclosing at least the brush of the catheter in a sleeve at least when withdrawing the catheter and the brush from the duct.
15. The method of claim 13, further comprising locating the catheter by externally detecting at least one radio-opaque marker on the catheter adjacent the brush during at least one of said inserting, pushing and pulling and said withdrawing steps.
US08178112 1994-01-06 1994-01-06 Catheter with simultaneous brush cytology and scrape biopsy capability Expired - Fee Related US5535756A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US08178112 US5535756A (en) 1994-01-06 1994-01-06 Catheter with simultaneous brush cytology and scrape biopsy capability

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08178112 US5535756A (en) 1994-01-06 1994-01-06 Catheter with simultaneous brush cytology and scrape biopsy capability
US08472122 US5738109A (en) 1994-01-06 1995-06-07 Catheter with simutaneous brush cytology and scrape biopsy capability

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US08472122 Division US5738109A (en) 1994-01-06 1995-06-07 Catheter with simutaneous brush cytology and scrape biopsy capability

Publications (1)

Publication Number Publication Date
US5535756A true US5535756A (en) 1996-07-16

Family

ID=22651250

Family Applications (2)

Application Number Title Priority Date Filing Date
US08178112 Expired - Fee Related US5535756A (en) 1994-01-06 1994-01-06 Catheter with simultaneous brush cytology and scrape biopsy capability
US08472122 Expired - Fee Related US5738109A (en) 1994-01-06 1995-06-07 Catheter with simutaneous brush cytology and scrape biopsy capability

Family Applications After (1)

Application Number Title Priority Date Filing Date
US08472122 Expired - Fee Related US5738109A (en) 1994-01-06 1995-06-07 Catheter with simutaneous brush cytology and scrape biopsy capability

Country Status (1)

Country Link
US (2) US5535756A (en)

Cited By (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5702413A (en) * 1996-01-11 1997-12-30 Scimed Life Systems, Inc. Curved bristle atherectomy device and method
WO1998034673A1 (en) 1997-02-12 1998-08-13 Prolifix Medical, Inc. Apparatus for removal of material from stents
US5865765A (en) * 1995-10-16 1999-02-02 Mohajer; Reza S. Dilator/sampler for sampling materials and fluid from a body cavity
WO1999009889A1 (en) * 1995-11-13 1999-03-04 Robert Arlin Goldenberg Apparatus for aspirating and collecting middle ear specimens
WO1999009888A1 (en) * 1996-01-26 1999-03-04 Robert Arlin Goldenberg Apparatus for collecting middle ear specimens
US5882332A (en) * 1997-06-06 1999-03-16 Wijay; Bandula Drug infusion catheter and method
US5882329A (en) * 1997-02-12 1999-03-16 Prolifix Medical, Inc. Apparatus and method for removing stenotic material from stents
WO1999030623A1 (en) * 1997-12-18 1999-06-24 Novare Surgical Systems, Inc. Surgical retractors and clamps with directional gripping filaments
US6099539A (en) * 1998-07-27 2000-08-08 Thomas J. Fogarty Surgical clamp pad with interdigitating teeth
WO2001015604A1 (en) * 1999-08-31 2001-03-08 The University Of Western Australia Methods and devices for obtaining samples from hollow viscera
US6228104B1 (en) 1999-06-18 2001-05-08 Novare Surgical Systems, Inc. Surgical clamp having replaceable pad
US6248081B1 (en) 1999-09-28 2001-06-19 Scimed Life Systems, Inc. Endoscopic submucosal core biopsy device
US6273902B1 (en) 1999-06-18 2001-08-14 Novare Surgical Systems, Inc. Surgical clamp having replaceable pad
US6277108B1 (en) 1999-06-04 2001-08-21 Medamicus, Inc. Introducer with location marker
US6299621B1 (en) 1999-06-18 2001-10-09 Novare Surgical Systems, Inc. Surgical clamp pads with elastomer impregnated mesh
WO2001039694A3 (en) * 1999-12-03 2001-12-20 Univ Leeds Repair of damaged tissue
US6352513B1 (en) 1999-06-25 2002-03-05 Ampersand Medical Corporation Personal cervical cell collector
US6387112B1 (en) 1999-06-18 2002-05-14 Novare Surgical Systems, Inc. Surgical clamp having replaceable pad
US20020082557A1 (en) * 1997-08-06 2002-06-27 Jackson Robert W. Irrigation system and tip with debrider
US6491692B1 (en) * 2000-08-21 2002-12-10 Robert Meislin Cartilage brush and method
US6500114B1 (en) 1993-11-23 2002-12-31 Dofi Technologies, Inc. Method of extracting biopsy cells from the breast
US6719766B1 (en) 2000-08-24 2004-04-13 Novare Surgical Systems, Inc. Surgical clamp pads having surface overlay
US6725492B2 (en) 1998-11-25 2004-04-27 Neosci Medical, Inc. Cleaning brush for medical devices
US20040236247A1 (en) * 2003-05-24 2004-11-25 Syed Rizvi Endocervical Curette
US20040260199A1 (en) * 2003-06-19 2004-12-23 Wilson-Cook Medical, Inc. Cytology collection device
US20050177068A1 (en) * 2000-12-20 2005-08-11 Fox Hollow Technologies, Inc. Debulking catheters and methods
US20050222518A1 (en) * 2004-04-06 2005-10-06 Genocell, Llc Biopsy and injection catheters
US20050256426A1 (en) * 2004-05-12 2005-11-17 William Brugge Apparatus and method for collecting tissue samples
US20060030786A1 (en) * 2004-08-06 2006-02-09 Li-Cheng Lu Personal cervical cell collector
US20060058800A1 (en) * 2002-12-03 2006-03-16 Trans1 Inc. Methods and apparatus for provision of therapy to adjacent motion segments
US20060074443A1 (en) * 1994-09-16 2006-04-06 Foerster Seth A Devices and methods for marking a biopsy site
US7214229B2 (en) 1999-03-18 2007-05-08 Fossa Medical, Inc. Radially expanding stents
US20070248946A1 (en) * 2006-03-02 2007-10-25 Crs Medical Diagnostics, Inc. Catheter testing system and uses thereof
US20070282223A1 (en) * 2006-06-01 2007-12-06 Daniel Larkin Method and apparatus for simultaneously collecting exocervical and endocervical samples
WO2009012392A1 (en) 2007-07-17 2009-01-22 Neal Marc Lonky Frictional trans-epithelial tissue disruption and collection apparatus and method of inducing and/or augmenting an immune response
US20090149880A1 (en) * 2006-04-12 2009-06-11 Bc & D Concepts Gmbh Occlusion System for Management of Rectal or Anal Incontinence
US7588574B2 (en) 2003-10-23 2009-09-15 Trans1 Inc. Kits for enabling axial access and procedures in the spine
US20090306702A1 (en) * 2004-08-23 2009-12-10 Elina Miloslavski Device for the Removal of Thrombi
US7674283B2 (en) 1999-03-18 2010-03-09 Fossa Medical, Inc. Radially expandable stents
US20100249649A1 (en) * 2006-06-01 2010-09-30 Daniel Larkin Method and apparatus for simultaneously collecting exocervical and endocervical samples
US20110060606A1 (en) * 2005-04-19 2011-03-10 Ev3 Inc. Libraries and data structures of materials removed by debulking catheters
US20110172557A1 (en) * 2007-07-17 2011-07-14 Histologics Llc Frictional trans-epithelial tissue disruption collection apparatus and method of inducing an immune response
US20110236902A1 (en) * 2004-12-13 2011-09-29 Tyco Healthcare Group Lp Testing a patient population having a cardiovascular condition for drug efficacy
WO2012103184A2 (en) * 2011-01-27 2012-08-02 Mayo Foundation For Medical Education And Research Cytological sample acquisition device and method
US8298244B2 (en) 2006-10-26 2012-10-30 Tyco Healtcare Group Lp Intracorporeal grasping device
US20140090642A1 (en) * 2012-09-28 2014-04-03 Kimberly-Clark Worldwide, Inc. Self Positioning Tracheal Tube Clearance Mechanism Using Skives
CN103860206A (en) * 2012-12-14 2014-06-18 崔晓华 Liquid sucking brush for bronchoscope and lungs
WO2015027009A1 (en) * 2013-08-21 2015-02-26 MKT Enterprises, LLC Apparatus and method for ovarian cancer screening
US8968213B2 (en) 2010-10-19 2015-03-03 United States Endoscopy Group, Inc. Cytology brush apparatus with improvements
US9039637B2 (en) 2013-03-13 2015-05-26 Cook Medical Technologies Llc Flexible cytology coil
US9044213B1 (en) 2010-03-26 2015-06-02 Histologics, LLC Frictional tissue sampling and collection method and device
US9095330B2 (en) 2013-03-13 2015-08-04 Cook Medical Technologies Llc Perforated tube for cell collection
US9119609B2 (en) 2013-03-13 2015-09-01 Cook Medical Technologies Llc Rotating cell collection device
US9320502B2 (en) 2013-03-12 2016-04-26 Cook Medical Technologies Llc Cytology balloon
US9814598B2 (en) 2013-03-14 2017-11-14 Quandary Medical, Llc Spinal implants and implantation system
US9820722B1 (en) 2008-12-16 2017-11-21 Zanetta Malanowska-Stega Simultaneous multiple method out-patient uterus biopsy device and method

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1010709C2 (en) 1998-12-02 2000-06-19 Mdz Beheer B V Brush suitable for taking a smear.
DE69928281D1 (en) * 1998-12-02 2005-12-15 Mdz Beheer B V Brush for removing a smear
CA2380714C (en) * 1999-08-13 2010-10-26 R. Lurie Pty. Ltd. Apparatus for obtaining biological samples
JP2003535622A (en) * 2000-05-09 2003-12-02 ユナイテッド ステーツ エンドスコピー グループ インコーポレイテッド Barrett's esophagus cytology device
US7108661B2 (en) * 2001-05-07 2006-09-19 United States Endoscopy Group, Inc. Method and collection device for Barrett's esophagus cells
EP1234543B1 (en) * 2000-08-04 2011-04-20 Olympus Optical Co., Ltd. Sampler
US7517323B2 (en) 2006-05-19 2009-04-14 Ng Raymond C Rotary device to gather mucous for testing
US20080097331A1 (en) * 2006-09-05 2008-04-24 Ethicon Endo-Surgery, Inc. Guidewire structure including a medical guidewire and method for using
DE102009011931A1 (en) * 2009-03-10 2010-09-16 Innora Gmbh A device for application of active ingredients on the wall of a body vessel
US8617144B2 (en) * 2010-04-07 2013-12-31 Sundaram Ravikumar Venous closure catheter and method for sclerotherapy
GB201012844D0 (en) * 2010-07-30 2010-09-15 Ferrett Colin G Body cavity sampling device
WO2013116529A1 (en) * 2012-01-31 2013-08-08 The Trustees Of Columbia University In The City Of New York Sampling catheter devices, methods, and systems
WO2013116560A1 (en) * 2012-01-31 2013-08-08 The Trustees Of Columbia University In The City Of New York Tissue sampling devices, methods, and systems
CA2899881A1 (en) * 2013-02-01 2014-08-07 Nvision Medical Corporation Methods and devices for fallopian tube diagnostics
WO2014149941A1 (en) 2013-03-15 2014-09-25 Cook Medical Technologies Llc Cell collector having an expandable mesh
US20150366545A1 (en) * 2014-06-18 2015-12-24 Cook Medical Technologies Llc Brush system for a cell collecting device

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3196876A (en) * 1961-05-10 1965-07-27 Maurice M Miller Dilator
GB1547328A (en) * 1978-01-19 1979-06-13 Celestin L R Apparatus for insertion into a body cavity
US4465072A (en) * 1983-02-22 1984-08-14 Taheri Syde A Needle catheter
US4726373A (en) * 1984-09-27 1988-02-23 Keymed (Medical & Industrial Equipment) Ltd Wire guided dilator device
US5201323A (en) * 1991-02-20 1993-04-13 Brigham & Women's Hospital Wire-guided cytology brush

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US513361A (en) * 1894-01-23 Churn

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3196876A (en) * 1961-05-10 1965-07-27 Maurice M Miller Dilator
GB1547328A (en) * 1978-01-19 1979-06-13 Celestin L R Apparatus for insertion into a body cavity
US4465072A (en) * 1983-02-22 1984-08-14 Taheri Syde A Needle catheter
US4726373A (en) * 1984-09-27 1988-02-23 Keymed (Medical & Industrial Equipment) Ltd Wire guided dilator device
US5201323A (en) * 1991-02-20 1993-04-13 Brigham & Women's Hospital Wire-guided cytology brush

Cited By (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6500114B1 (en) 1993-11-23 2002-12-31 Dofi Technologies, Inc. Method of extracting biopsy cells from the breast
US20060074443A1 (en) * 1994-09-16 2006-04-06 Foerster Seth A Devices and methods for marking a biopsy site
US5865765A (en) * 1995-10-16 1999-02-02 Mohajer; Reza S. Dilator/sampler for sampling materials and fluid from a body cavity
WO1999009889A1 (en) * 1995-11-13 1999-03-04 Robert Arlin Goldenberg Apparatus for aspirating and collecting middle ear specimens
US5702413A (en) * 1996-01-11 1997-12-30 Scimed Life Systems, Inc. Curved bristle atherectomy device and method
WO1999009888A1 (en) * 1996-01-26 1999-03-04 Robert Arlin Goldenberg Apparatus for collecting middle ear specimens
US6319242B1 (en) 1997-02-12 2001-11-20 Prolifix Medical, Inc. Apparatus and method for controlled removal of stenotic material from stents
WO1998034673A1 (en) 1997-02-12 1998-08-13 Prolifix Medical, Inc. Apparatus for removal of material from stents
US5882329A (en) * 1997-02-12 1999-03-16 Prolifix Medical, Inc. Apparatus and method for removing stenotic material from stents
US5902263A (en) * 1997-02-12 1999-05-11 Prolifix Medical, Inc. Apparatus and method for removing stenotic material from stents
US5941869A (en) * 1997-02-12 1999-08-24 Prolifix Medical, Inc. Apparatus and method for controlled removal of stenotic material from stents
US5882332A (en) * 1997-06-06 1999-03-16 Wijay; Bandula Drug infusion catheter and method
US7070574B2 (en) * 1997-08-06 2006-07-04 C.R. Bard, Inc. Irrigation system and tip with debrider
US20020082557A1 (en) * 1997-08-06 2002-06-27 Jackson Robert W. Irrigation system and tip with debrider
US6007552A (en) * 1997-12-18 1999-12-28 Minumys Vascular clamps and surgical retractors with directional filaments for tissue engagement
WO1999030623A1 (en) * 1997-12-18 1999-06-24 Novare Surgical Systems, Inc. Surgical retractors and clamps with directional gripping filaments
US6461368B2 (en) 1997-12-18 2002-10-08 Novare Surgical Systems, Inc. Vascular clamps and surgical retractors with directional filaments for tissue engagement
US6312445B1 (en) 1997-12-18 2001-11-06 Novare Surgical Systems, Inc. Vascular clamps and surgical retractors with directional filaments for tissue engagement
US6165186A (en) * 1997-12-18 2000-12-26 Novare Surgical Systems, Inc. Vascular clamps and surgical retractors with directional filaments for tissue engagement
US6206896B1 (en) 1998-07-27 2001-03-27 Thomas J. Fogarty Surgical clamp pad with interdigitating teeth
US6387106B1 (en) 1998-07-27 2002-05-14 Thomas J. Fogarty, M.D. Surgical clamp pad with interdigitating teeth
US6099539A (en) * 1998-07-27 2000-08-08 Thomas J. Fogarty Surgical clamp pad with interdigitating teeth
US6989017B2 (en) 1998-07-27 2006-01-24 Thomas J. Fogarty Surgical clamp pad with interdigitating teeth
US20020183785A1 (en) * 1998-07-27 2002-12-05 Howell Thomas A. Surgical clamp pad with interdigitatin teeth
US20040158945A1 (en) * 1998-11-25 2004-08-19 Moore P. Timothy Cleaning brush for medical devices
US6725492B2 (en) 1998-11-25 2004-04-27 Neosci Medical, Inc. Cleaning brush for medical devices
US6920662B2 (en) * 1998-11-25 2005-07-26 Neosci Medical, Inc. Cleaning brush for medical devices
US7214229B2 (en) 1999-03-18 2007-05-08 Fossa Medical, Inc. Radially expanding stents
US7674283B2 (en) 1999-03-18 2010-03-09 Fossa Medical, Inc. Radially expandable stents
US6277108B1 (en) 1999-06-04 2001-08-21 Medamicus, Inc. Introducer with location marker
US6273902B1 (en) 1999-06-18 2001-08-14 Novare Surgical Systems, Inc. Surgical clamp having replaceable pad
US6530942B2 (en) 1999-06-18 2003-03-11 Novare Surgical Systems, Inc. Surgical clamp having replaceable pad
US6228104B1 (en) 1999-06-18 2001-05-08 Novare Surgical Systems, Inc. Surgical clamp having replaceable pad
US6558408B1 (en) 1999-06-18 2003-05-06 Novare Surgical Systems, Inc. Surgical clamp having replaceable pad
US6692514B2 (en) 1999-06-18 2004-02-17 Novare Surgical Systems, Inc. Surgical clamp having replaceable pad
US6387112B1 (en) 1999-06-18 2002-05-14 Novare Surgical Systems, Inc. Surgical clamp having replaceable pad
US6299621B1 (en) 1999-06-18 2001-10-09 Novare Surgical Systems, Inc. Surgical clamp pads with elastomer impregnated mesh
US6352513B1 (en) 1999-06-25 2002-03-05 Ampersand Medical Corporation Personal cervical cell collector
WO2001015604A1 (en) * 1999-08-31 2001-03-08 The University Of Western Australia Methods and devices for obtaining samples from hollow viscera
US6248081B1 (en) 1999-09-28 2001-06-19 Scimed Life Systems, Inc. Endoscopic submucosal core biopsy device
US7137956B2 (en) 1999-09-28 2006-11-21 Boston Scientific Scimed, Inc. Endoscopic submucosal core biopsy device
US7981052B2 (en) 1999-09-28 2011-07-19 Boston Scientific Scimed, Inc. Endoscopic submucosal core biopsy device
US6551254B2 (en) 1999-09-28 2003-04-22 Scimed Life Systems Endoscopic submucosal core biopsy device
US20070123800A1 (en) * 1999-09-28 2007-05-31 Boston Scientific Scimed, Inc. Endoscopic submucosal core biopsy device
US20080147069A1 (en) * 1999-12-03 2008-06-19 University Of Leeds Fixation technology
WO2001039694A3 (en) * 1999-12-03 2001-12-20 Univ Leeds Repair of damaged tissue
US7427284B2 (en) 1999-12-03 2008-09-23 University Of Leeds Fixation technology
US7867232B2 (en) 1999-12-03 2011-01-11 University Of Leeds Fixation technology
US20080183300A1 (en) * 1999-12-03 2008-07-31 University Of Leeds Fixation technology
US6491692B1 (en) * 2000-08-21 2002-12-10 Robert Meislin Cartilage brush and method
US20040167552A1 (en) * 2000-08-24 2004-08-26 Novare Surgical Systems, Inc. Surgical clamp pads having surface overlay
US6719766B1 (en) 2000-08-24 2004-04-13 Novare Surgical Systems, Inc. Surgical clamp pads having surface overlay
US20050177068A1 (en) * 2000-12-20 2005-08-11 Fox Hollow Technologies, Inc. Debulking catheters and methods
US7699790B2 (en) * 2000-12-20 2010-04-20 Ev3, Inc. Debulking catheters and methods
US8523918B2 (en) 2002-12-03 2013-09-03 Baxano Surgical, Inc. Therapy to adjacent motion segments
US8328847B2 (en) 2002-12-03 2012-12-11 Trans1 Inc. Assemblies for provision of therapy to motion segments
US8167947B2 (en) 2002-12-03 2012-05-01 Trans1 Inc. Methods for push distraction and for provision of therapy to adjacent motion segments
US20060058800A1 (en) * 2002-12-03 2006-03-16 Trans1 Inc. Methods and apparatus for provision of therapy to adjacent motion segments
US7776042B2 (en) 2002-12-03 2010-08-17 Trans1 Inc. Methods and apparatus for provision of therapy to adjacent motion segments
US20040236247A1 (en) * 2003-05-24 2004-11-25 Syed Rizvi Endocervical Curette
US20040260199A1 (en) * 2003-06-19 2004-12-23 Wilson-Cook Medical, Inc. Cytology collection device
US8052613B2 (en) * 2003-10-23 2011-11-08 Trans1 Inc. Spinal nucleus extraction tool
US7588574B2 (en) 2003-10-23 2009-09-15 Trans1 Inc. Kits for enabling axial access and procedures in the spine
US7799033B2 (en) 2003-10-23 2010-09-21 Trans1 Inc. Access kits for enabling axial access and procedures in the spine
US20050222518A1 (en) * 2004-04-06 2005-10-06 Genocell, Llc Biopsy and injection catheters
US20050256426A1 (en) * 2004-05-12 2005-11-17 William Brugge Apparatus and method for collecting tissue samples
US20060030786A1 (en) * 2004-08-06 2006-02-09 Li-Cheng Lu Personal cervical cell collector
US7144377B2 (en) * 2004-08-06 2006-12-05 Li-Cheng Lu Personal cervical cell collector
US20090306702A1 (en) * 2004-08-23 2009-12-10 Elina Miloslavski Device for the Removal of Thrombi
US9707002B2 (en) 2004-08-23 2017-07-18 Phenox Gmbh Device for the removal of thrombi
US20110236902A1 (en) * 2004-12-13 2011-09-29 Tyco Healthcare Group Lp Testing a patient population having a cardiovascular condition for drug efficacy
US20110060606A1 (en) * 2005-04-19 2011-03-10 Ev3 Inc. Libraries and data structures of materials removed by debulking catheters
US20100305471A1 (en) * 2006-03-02 2010-12-02 Robert Brewer Catheter testing system and uses thereof
US8292825B2 (en) 2006-03-02 2012-10-23 Crs Medical Diagnostics, Inc. Catheter testing system and uses thereof
US7785270B2 (en) * 2006-03-02 2010-08-31 Crs Medical Diagnostics, Inc. Catheter testing system and uses thereof
US20070248946A1 (en) * 2006-03-02 2007-10-25 Crs Medical Diagnostics, Inc. Catheter testing system and uses thereof
US20090149880A1 (en) * 2006-04-12 2009-06-11 Bc & D Concepts Gmbh Occlusion System for Management of Rectal or Anal Incontinence
US20100305472A1 (en) * 2006-06-01 2010-12-02 Daniel Larkin Method and apparatus for simultaneously collecting exocervical and endocervical samples
US20100249649A1 (en) * 2006-06-01 2010-09-30 Daniel Larkin Method and apparatus for simultaneously collecting exocervical and endocervical samples
US8251918B2 (en) 2006-06-01 2012-08-28 Daniel Larkin Method and apparatus for simultaneously collecting exocervical and endocervical samples
US20070282223A1 (en) * 2006-06-01 2007-12-06 Daniel Larkin Method and apparatus for simultaneously collecting exocervical and endocervical samples
US8439847B2 (en) * 2006-06-01 2013-05-14 Daniel Larkin Method and apparatus for simultaneously collecting exocervical and endocervical samples
US7749173B2 (en) * 2006-06-01 2010-07-06 Daniel Larkin Apparatus for simultaneously collecting exocervical and endocervical samples
US8298244B2 (en) 2006-10-26 2012-10-30 Tyco Healtcare Group Lp Intracorporeal grasping device
US20140243705A1 (en) * 2007-07-17 2014-08-28 Histologics Llc Frictional trans-epithelial tissue disruption collection apparatus and method of inducing an immune response
US9393394B2 (en) 2007-07-17 2016-07-19 Histologics, LLC Frictional trans-epithelial tissue disruption and collection apparatus and method of inducing or augmenting an immune response
US9687642B2 (en) 2007-07-17 2017-06-27 Histologics, LLC Frictional trans-epithelial tissue disruption and collection apparatus and method of inducing or augmenting an immune response
WO2009012392A1 (en) 2007-07-17 2009-01-22 Neal Marc Lonky Frictional trans-epithelial tissue disruption and collection apparatus and method of inducing and/or augmenting an immune response
US8652067B2 (en) * 2007-07-17 2014-02-18 Histologics, LLC Frictional trans-epithelial tissue disruption and collection apparatus and method of inducing and/or augmenting an immune response
US9282951B2 (en) * 2007-07-17 2016-03-15 Histologics, LLC Frictional trans-epithelial tissue disruption collection apparatus and method of inducing an immune response
US20100210968A1 (en) * 2007-07-17 2010-08-19 Histologics Llc Frictional trans-epithelial tissue disruption and collection apparatus and method of inducing and/or augmenting an immune response
US8795197B2 (en) * 2007-07-17 2014-08-05 Histologics, LLC Frictional trans-epithelial tissue disruption collection apparatus and method of inducing an immune response
US20110172557A1 (en) * 2007-07-17 2011-07-14 Histologics Llc Frictional trans-epithelial tissue disruption collection apparatus and method of inducing an immune response
US9820722B1 (en) 2008-12-16 2017-11-21 Zanetta Malanowska-Stega Simultaneous multiple method out-patient uterus biopsy device and method
US9044213B1 (en) 2010-03-26 2015-06-02 Histologics, LLC Frictional tissue sampling and collection method and device
US8968213B2 (en) 2010-10-19 2015-03-03 United States Endoscopy Group, Inc. Cytology brush apparatus with improvements
WO2012103184A2 (en) * 2011-01-27 2012-08-02 Mayo Foundation For Medical Education And Research Cytological sample acquisition device and method
WO2012103184A3 (en) * 2011-01-27 2012-11-01 Mayo Foundation For Medical Education And Research Cytological sample acquisition device and method
US20140090642A1 (en) * 2012-09-28 2014-04-03 Kimberly-Clark Worldwide, Inc. Self Positioning Tracheal Tube Clearance Mechanism Using Skives
US9131988B2 (en) * 2012-09-28 2015-09-15 Avent, Inc. Self positioning tracheal tube clearance mechanism using skives
CN103860206A (en) * 2012-12-14 2014-06-18 崔晓华 Liquid sucking brush for bronchoscope and lungs
CN103860206B (en) * 2012-12-14 2016-03-02 崔晓华 Absorbent liquid for a bronchoscopic brush and lung
US9320502B2 (en) 2013-03-12 2016-04-26 Cook Medical Technologies Llc Cytology balloon
US9119609B2 (en) 2013-03-13 2015-09-01 Cook Medical Technologies Llc Rotating cell collection device
US9095330B2 (en) 2013-03-13 2015-08-04 Cook Medical Technologies Llc Perforated tube for cell collection
US9039637B2 (en) 2013-03-13 2015-05-26 Cook Medical Technologies Llc Flexible cytology coil
US9814598B2 (en) 2013-03-14 2017-11-14 Quandary Medical, Llc Spinal implants and implantation system
WO2015027009A1 (en) * 2013-08-21 2015-02-26 MKT Enterprises, LLC Apparatus and method for ovarian cancer screening

Also Published As

Publication number Publication date Type
US5738109A (en) 1998-04-14 grant

Similar Documents

Publication Publication Date Title
US5499989A (en) Breast biopsy apparatus and method of use
US5846248A (en) Method and apparatus for severing and capturing polyps
US6488636B2 (en) Biopsy apparatus
US7229417B2 (en) Methods for marking a biopsy site
US6261302B1 (en) Applier for implantable surgical marker
US5759187A (en) Surgical retrieval assembly and associated method
US6432064B1 (en) Biopsy instrument with tissue marking element
US6280450B1 (en) Breast surgery method and apparatus
US6540693B2 (en) Methods and apparatus for securing medical instruments to desired locations in a patients body
US6019733A (en) Biopsy apparatus and method
US6758848B2 (en) Apparatus and method for accessing a body site
US5823970A (en) Biopsy needle set
US5449001A (en) Biopsy needle
US5913857A (en) Methods and devices for collection of soft tissue
US6468227B2 (en) Device for performing a medical procedure
US20070021731A1 (en) Method of and apparatus for navigating medical devices in body lumens
US5059197A (en) Lesion location device
US6626903B2 (en) Surgical biopsy device
US5573008A (en) Multiple biopsy sampling coring device
US7424320B2 (en) Tissue localizing and marking device and method of using same
US20050085808A1 (en) Medical instrument with indented loop and associated method
US20080154090A1 (en) Endoscopic System for In-Vivo Procedures
US6136014A (en) Percutaneous tissue removal device
US5800389A (en) Biopsy device
US20060195118A1 (en) Distal release retrieval assembly and related methods of use

Legal Events

Date Code Title Description
REMI Maintenance fee reminder mailed
SULP Surcharge for late payment
FPAY Fee payment

Year of fee payment: 4

REMI Maintenance fee reminder mailed
LAPS Lapse for failure to pay maintenance fees
FP Expired due to failure to pay maintenance fee

Effective date: 20040716

AS Assignment

Owner name: COOK MEDICAL TECHNOLOGIES LLC, INDIANA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:COOK INCORPORATED;WILSON-COOK MEDICAL INCORPORATED;VANCEPRODUCTS INCORPORATED;AND OTHERS;SIGNING DATES FROM 20110315 TO 20110322;REEL/FRAME:026287/0923