US531889A

US531889A - Preparing germ matter for medicinal use

Info

Publication number: US531889A
Authority: US
Publication date: 1895-01-01
Anticipated expiration: 1912-01-01

Description

(No Model.)

- .J. R. WITZEL. M

PREPARING GERM MATTER FOR MEDICINAL USE-- Patented Jan. 1, 1895.

M. Z a

UNITED STATES PATENT FFIGE.

JosnPn n. .WI'rzEL, OF PHILADELPHIA, PENNSYLVANIA,

PREPARING (iiERM MATTER FOR MEDICINAL USE.

srscuuon'rron forming sea of Letters Patent no. senses, dated-January 1, 1895.

Appliostion filed November 27,1891. Serial No. 413.221. (No model.)

To all whom it may concern:

Be it known that I, JOSEPH R. WITZEL, a citizen of the United States, residing in the city and county of Philadelphia, State of Pennsylvania, have invented a new and useful Improvement in Methods of Preparing Germ Matter for Medicinal Use, which immentary constituents of the said germ or germ material, and rendering it better lit for therapeutic purposes, and for this purpose it consists of the method hereinafter set forth, whereby the germ matter as taken from the corpse, saidmatter being in either a solid or a liquid condition, or partly solidand partly liquid, is placed in'z'acuo and subjected to a series of succussions and dilutions for the purpose described.

In the figure inthe drawing, which represents a side view of a device or apparatus suitable for carrying out my process, A designates a box or other vessel suitably supported in or on one end of the lever B, the-other end of said lever being pivoted to a standardror frame 0.

, Projecting from one side ot the lever'B is a pin D, which fits in a cam grooveE in the side of the wheel F secured to the .shhft G. The said shaft is mounted in the frame 0, and is provided with a handle II for rotating it.

' The vessel A is adapted to inclose a vial or other suitable vessel J, containing t e germ matter in vacuo, and is provided with soap K, which, when screwed on the body of the vessel A,bears against the cork'L of the vial J, so as to keep the same'ln place. The vial J is provided with a valve M for opening or- .closing the mouth-thereof.

Incan'ying out. my process of preparing the germ matter for medicinal use, the said matter is placed in the vial J, which may be of any shape, so as to occupy about one-third of the space within the same. withdrawn from the vial by means of an air; exhaust pump,

of the vial closed. The vial J is now placed.

The air is now and the valve M in the mouth in the box A, and the cap K screwed thereon,

so as to bear against the cork L, which had been inserted in the mouth of the vial J, and thereby hold the latter in position within the box A, while the shaft G is rotated by means of the handle H, so as to rotate the wheel F, and thereby raise and lower the lever 13, thus imparting a. series of succussions to the germ matter held in oacub in the vial J. After the era: matter has been suh ected to the sucb cussions for about five minutes heat is applied to the same, and the germ matter kept at boiling point until all vitality therein is destroyed. cool room. If, after cooling, it is discovered by microscopic examination or otherwise, that the germs still have vitality, the material is again placed in 'vacuo, and a quantity of nitrogen gas is introduced in any suitable manner, so as to fill the germ material. After It is then set aside in a dark and being kept inlthis condition for about nine hours and being subjected to a number of successions so as to bring the germ Q'nass in contact with the nitrogen, the latter is removed from the germs which dccup'y about one-third of the vial, and the air withdrawn from the same, and the germs again subjected to a series of successions. Air is now allowed to enter the vial and the germ material is diluted with distilled water, alcohol or any other suitable fluid, to any desired-proportion, preferably one part of germ matter to nine parts oi alcohol, when it is poured into asuitable vessel or jar provided with a valve for attachment of an air pump thereto. The said vessel being about one-third full of germ matter, 1 has the air withdrawn from it, and the material therein issubjected to a number of succussions. Air is now allowed to enter the vessel and fill the vacuum. The germ material.

is again diluted with alcohol or any other suitable fluids, andis treated inlike'manner, asz vat the preceding dilution. ,By thns succussion in 'vacuo depriving the germ material of air and separating the molecules so as to aid capillary absorption by the blood vessels. 'lhe germ or germ material prepared as described, may be used internally or exterrlally, by vaccination, injection, or as a spray.

By having the germ matter placed in vacuo before succussion, the air cells'are dilated,

and are more easily broken or severed. The air and its impurities are removed, thus affording the best condition for succussing or agitating as the liquid strikes the vessel with out a cushion. Particles held in solution or suspension are more finely divided and subdivided, and therebyincrease and aid capillary absorpti nby the blood vessels. It makes a more unifo m mixture and improves the keeping qualities of articles in vacuo. In many cases it requires less material or medicine to producethe desired therapeutic efiects, as the absorption is more readily accomplished by the capillary vessels when cells or particles are finely divided and sub-divided. Having thus described my invention, what I claim as new, and desire to secure by Letters Patent, is--" I 1. The process of preparing medicinal substances, consisting'in first placing the said substance in vacuo, and then subjecting it when in the same to a number of succu-ssions, substantially as described.

2. The process of preparing germ matter for medicinal use, consisting in first placing the same in vacuo, and while therein subjecting the same to succussions, then removing and diluting it, and again subjecting it in vacuo to succussion, substantially as described.

3. Theprocess of preparing germ matter for medicinal use, consisting in first placing the same in vacuo, and while therein subjecting it to succussions, then admitting air and diluting the said matter, heatingit and subjecting it to further succussions, substantially as described.

4. The process of preparing'germ matter for medicinal use, consisting in first placing the same in vacuo, then subjecting it to a se-' ries of succussions, then repeatedly diluting it in air and subjecting itto succussions in vacuo, next introducing a vitality-destroying gas or substance into the mass so treated, and then subjecting it to successions as before, substantially as described.

. JOSEPH R. 'WI'lZEl. l itnesses:

JOHN A. WIEDERSi-IEIM, A. P. JENNINGS.