US5041133A - Intraocular implant - Google Patents
Intraocular implant Download PDFInfo
- Publication number
- US5041133A US5041133A US07/054,216 US5421687A US5041133A US 5041133 A US5041133 A US 5041133A US 5421687 A US5421687 A US 5421687A US 5041133 A US5041133 A US 5041133A
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- US
- United States
- Prior art keywords
- implant
- lens
- thermoplastic polymer
- ocular implant
- intraocular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1602—Corrective lenses for use in addition to the natural lenses of the eyes or for pseudo-phakic eyes
- A61F2/1605—Anterior chamber lenses for use in addition to the natural lenses of the eyes, e.g. iris fixated, iris floating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
Definitions
- This invention relates to an improved intraocular implant which may be permanently placed within the human eye for the correction of conditions such as aphakia, myopia and corneal, retinal and other ocular impairment and re-establishment of binocularity in aphakia.
- Ocular implants such as corneal lamellar inlays and intraocular lenses can be used to correct certain degenerative ophthalmic conditions and to replace the natural lens of the eye.
- ocular implants such as corneal lamellar inlays and intraocular lenses can be used to correct certain degenerative ophthalmic conditions and to replace the natural lens of the eye.
- Intraocular lenses are exemplary of such implants and have a lens and a haptic for fixation of the lens, by a surgeon, in the anterior or posterior chamber of the human eye.
- the haptic may be of a variety of shapes depending, to some extent, on whether the lens is to be implanted in the anterior or posterior chamber of the eye.
- the Iridocapsular (Two-loop) Lens and Iris-Clip (Four-loop) Lens in Pseudophakia September-October, 1973, edition of Transactions of the American Academy of Ophthalmology and Otolaryngology.
- U.S. Pat. No. 4,198,714 discloses a method for implantation of an intraocular lens, preferably made from PMMA, into the posterior chamber of the human eye within the capsular membrane thereof. It is disclosed that the lens was implanted by removing a portion of the capsular membrane so that the intraocular lens could be inserted behind the iris. A first loop attached to the lens was placed in a pocket formed by the remaining portion of the capsular membrane. The iris is then pulled around the second supporting loop so that the entire lens together with its loops is placed into the posterior chamber of the human eye. It is disclosed that the anterior side of this pocket and the posterior side of the pocket eventually scar together, thereby securing the lens within the posterior chamber.
- an intraocular lens preferably made from PMMA
- the intraocular lens is said to be firmly, permanently and securely fixed to the capsular membrane and the iris is free to function normally. It is also taught that the use of an integral molded member eliminates edge reflections which occur in lenses implanted in the anterior chamber and internal reflections which are caused by posts for the supporting loops in other lenses implanted in the posterior chamber.
- intraocular lenses can have other haptics such as Hessburg or J-Loop designs as well as other diverse haptic means.
- PMMA polypropylene
- Polypropylene is not as brittle and has greater mechanical strength and toughness than PMMA.
- PMMA is the present plastic of choice as the lens material because it has good optical properties and has demonstrated excellent biocompatibility in the eye.
- PMMA has several disadvantages.
- PMMA is a relatively brittle, glassy polymer with a low glass transition temperature (Tg) of about 90° C., a low thermal stability, and relatively poor mechanical strength.
- Tg glass transition temperature
- PMMA also transmits a substantial portion of ultraviolet light which may be harmful to the aphakic eye.
- prior art workers have added UV absorbers.
- the mechanical and optical properties of PMMA also come to issue for ocular implants such as keratoprosthesis and other corneal implants; and implants emphasizing strength and biocompatibility such as retinal tacks and glaucoma shunts.
- PMMA intraocular implants made of PMMA cannot be sterilized by autoclaving with steam because of the high temperatures employed (about 120° C.-125° C.). At such temperatures PMMA becomes soft and distorted. Moreover, PMMA lenses are not sterilized using high energy radiation, e.g. Gamma sterilization at from 2 to 5 megarads, because of uncertainties regarding PMMA degradation and resulting problems of biocompatibility. Accordingly, PMMA intraocular implants are sterilized by techniques such as ethylene-oxide or other chemical or gas sterilization methods.
- sterilization procedures for implantation of ocular lenses and other ocular implants need to be very short so that a minimum amount of time is required.
- Chemical and gas sterilization methods are generally reserved for those incidences where steam and radiation sterilization cannot be employed.
- PMMA has heretofore been the plastic generally used for lenses it was not generally used as the haptic.
- PMMA was the material generally used to make the lens
- PMMA has been suggested and used as the haptic in integral implants.
- PMMA haptics cannot, of course, be sterilized using steam or radiation.
- PMMA has a notched Izod impact strength of one-eighth inch thickness of about 0.3-0.4 ft.
- an intraocular implant material which is strong, ductile, easily machined or molded into thin sections, having a specific gravity of less than 2, preferably less than 1.7, and especially preferably about 1.4 or lower, which is chemically inert and stable and capable of withstanding autoclave steam sterilization without softening or permanent distortion or high energy radiation sterilization without causing an adverse change in properties.
- an intraocular implant to be stable and withstand the energy when a laser beam is passed therethrough.
- the posterior capsule becomes opaque. This obscures the vision and therefore requires removal of a small portion of the capsule which is located horizontally to the intraocular lens.
- This removal of a portion of the posterior capsule is preferably done by passing a laser beam through the intraocular lens and burning a hole in the capsule.
- the lens must be stable to laser energy and therefore it is preferable if the lens has greater stability and strength than is possible using PMMA.
- an object of this invention to provide an intraocular lens and/or other ocular implants and/or haptic having superior mechanical thermal and sterilization properties to that of PMMA intraocular implants.
- Our invention provides an ocular said implant having thermal stability of at least 125° C. and also having the characteristic of stability when autoclaved sterilized or sterilized with high energy radiation such as Gamma radiation at from 2-5 megarads.
- the implant has good mechanical strength and ductility as measured by a notched Izod impact strength. This enables those skilled in the art to make thinner and more versatile lenses which are more resistant to handling and manufacturing processes than is possible with PMMA and stronger, safer, thinner integral haptic, including monofilament loop designs.
- the lens itself in addition to the properties set out above for the ocular implant, will have good optical properties and will have finished front and rear surfaces.
- intraocular implants in particular, such implants have an optic lens and haptics for fixation of said lens in the posterior or anterior chamber of the eye.
- the haptic need not have the optical properties set out above for the lens, but must possess the required mechanical strength. Haptics made of plastics, such as polypropylene, may be used in the present invention. However, it is preferred that the haptic be made of the same material as the lens in order to have an integral or one piece intraocular implant.
- thermoplastic polymers preferably linear thermoplastic polymers
- the haptic is also made from such thermoplastic polymers.
- thermoplastic polymer has repeating units of aromatic groups the thermoplastic will have the desired thermal and optical properties.
- the remaining desired properties of the lens are achieved by having the aromatic groups linked together by one or more of the following linkages; ether, ester, carbonyl and/or imide.
- ester as used herein, includes the carbonate linkage; aromatic polycarbonates are polymers coming within the scope of our invention.
- the aromatic groups useful in this invention as the repeating unit of the thermoplastic polymer include groups having an aromatic ring (including heterocyclic compounds).
- the aromatic groups include, but are not limited to, phenyl, biphenyl, naphthyl, anthracyl phenathryl, and alkylidenediphenyl. All of these groups may be substituted with substituents which do not adversely effect the thermal and high energy stability or biocompatability of the thermoplastic polymer, such as aliphatic (e.g. lower alkyl).
- substituents which do not adversely effect the thermal and high energy stability or biocompatability of the thermoplastic polymer, such as aliphatic (e.g. lower alkyl).
- Specific examples of various aromatic groups are phenyl, isopropylidenediphenyl, biphenyl, naphthyl, etc..
- linear aromatic polyester thermoplastic polymers is linear aromatic polycarbonate which, as is known in the art, is a thermoplastic polymer in which groups of dihydric phenols are linked through carbonate groups to form the following structure: ##STR1## where R is aromatic, preferably isopropylidenediphenyl or phenyl and n is greater than 20, e.g. 40 to 800 or more.
- Aromatic polycarbonates are tough, stiff and relatively hard plastics which maintain their properties over a wide temperature range and can have molecular weights of 200,000 or greater.
- polycarbonate derived from bis-phenol A has a glass transition (Tg) of about 140° C. and is tough, strong and characterized by a notched Izod impact strength greater than 10 ft. lbs./in..
- Tg glass transition
- bisphenol A as used herein it is meant para, para'-isopropylidenediphenol.
- Polycarbonates may be oriented and crystallized by drawing and thermal treatments. Bisphenol A polycarbonates yield transparent bodies on cooling of the melt after conventional molding or extrusion or on rapid evaporation of solvents.
- aromatic polycarbonates depend on their molecular weight. For example, molecular weights above about 18,000 produce excellent tensile and impact properties. The dimensional stability of polycarbonates is very good. Polycarbonates also can be formulated and produced to have extraordinarily high impact strength. As mentioned before, polycarbonates may be oriented and crystallized by drawing and the tensile strength will be significantly increased in the direction of the stress. Index of refraction for many aromatic polycarbonates ranges from about 1.56 to about 1.66 and consequently they are optically well-suited for intraocular lenses.
- aromatic polycarbonates having an average molecular weight between 15,000 and 50,000 can be injection molded and extruded between 220° C. and 350° C. using conventional procedures and equipment.
- tough, durable, intraocular lenses can be produced from polycarbonates which can be formed into lightweight thin cross-sections which can be autoclaved sterilized with essentially no permanent change in lens physical and chemical properties and lens dimensions.
- thermoplastic is General Electric Company's Lexan (trademark) polycarbonate. Lexan has repeating units of isopropylidenediphenyl groups connected by the carbonate ester linkage.
- polyarylates are aromatic polyesters of phthalic acids and diphenols and have thermal stability and high notched Izod impact strength at one-eighth inch; often greater than 4 ft.-lb./in..
- a preferred polyarylate is made from iso- and terephthalic acids and bisphenol A in a one to one weight ratio and has a Tg of about 170° C.
- Another useful polyester is that derived from Bisphenol-A, iso- and terephthalic acid and also containing carbonate linkages. This polyester has a Tg of about 160° C. and high impact strength.
- One example is a high temperature Lexan available from General Electric.
- thermoplastic high impact, high temperature, transparent polymers are polyetherimides which have both ether and imide linkages.
- a preferred polyetherimide also contains both phenyl and isopropylidene diphenyl groups.
- Such a polymer has the following repeating units: ##STR2## This polymer is available under the trademark Ultem from General Electric.
- Another class of aromatic polymers useful in the present invention are those having carbonyl (ketone) linkages.
- carbonyl (ketone) linkages are those having carbonyl (ketone) linkages.
- preferred carbonyl polymers are polyetherketones which are tough, strong, transparent thermoplastics having a high Tg. They are manufactured by ICI Americas Inc. and are polymers having aromatic groups which are alternately linked by an ether bridge and a carbonyl bridge.
- the intraocular lenses of this invention have optically finished front and rear surfaces, edge surfaces configurations and finishes which are compatible with the eye, and a configuration which is operative for implantation without extraction of the natural lens of the eye, or both.
- the intraocular lens cross section is thin enough, that when implanted in the human eye, it will not cause significant strain to the eye.
- the material not only affords greater strength, but its optical properties and biocompatibility also make possible such implants as corneal lamellar inlays, epikeratophakia implants, and keratoprosthes.
- the strength and biocompatibility also allow for other ophthalmic implant uses, e.g., retinal tacks (mechanical fasteners for treatment of detached retinae), glaucoma shunts (implants designed to relieve excessive intraocular pressure by allowing aqueous outflow) and orbital replacement (implanted replacement of bone and other tissues of the orbit).
- the superior thermal and chemical stability of the aromatic thermoplastics of the present invention are also of special importance in enabling sterilization by autoclave or irradiation methods, thus making them much more useful than conventional PMMA intraocular lenses.
- FIG. 1 is an illustration in plan view of an intraocular implant for implantation in the anterior chamber of the eye.
- FIG. 2 is a side view of the intraocular implant of FIG. 1.
- FIG. 3 is an illustration in plan view of a cornea inlay lens for implantation in the corneal stroma.
- FIG. 4 is a side view of the ocular implant of FIG. 3.
- the optic lens 10 of the intraocular implant is circular and of approximately the same size as the lens of the eye.
- the optic lens 10 is a solid thermoplastic aromatic polymer having one or more ether, ester, carbonyl or imide linkages, and which has thermal stability in the presence of steam at a temperature of 120° C. or higher and is transparent to visible light, is biocompatible, has a glass transition temperature of at least 120° C. and has a notched Izod impact strength at one-eighth inch thickness of at least about four foot pounds per inch.
- haptic 11 and lower haptic 12 Connected to the optic lens 10 are upper haptic 11 and lower haptic 12 which are, in the exemplary embodiment, for positioning and fixing the implant in the anterior chamber of the eye.
- the haptics 11 and 12 are made of a solid thermoplastic polymer having the same properties as that of optic lens 10 (except for the optical properties) and, in the preferred exemplary embodiment, are made of the same thermoplastic polymer as the optic lens 10.
- haptic 11 and haptic 12 are resilient so that they can be compressed when being placed in the eye but will spring out when the implant is in the correct position so that positioning element 13 of haptic 11 and positioning element 14 of haptic 12 will contact and be seated in the groove of the anterior chamber of the eye.
- Aperture 15 of positioning element 13 and aperture 16 of positioning element 14 are provided for grasping with forceps.
- the implant 110 is of the type generally used in corneal lamellar inlays and is preferably placed in the corneal stroma for correction of conditions such as aphakia, myopia, and hyperopia.
- the implant 110 is preferably a solid thermoplastic aromatic polymer having the same characteristics as discussed with respect to the exemplary embodiment of the present invention as shown in FIGS. 1 and 2.
- this embodiment of a corneal inlay lens disclosed is provided with a generally circular configuration to lens 110 and includes a number of holes or apertures 120 to allow nutrient flow from the inside of the eye to the epithelium. It is to be understood that holes 120 need not be utilized and that alternative patterns and hole sizes may be utilized as well.
- circumference points 122 and 124 define a lens diameter "X”.
- circumference point 124 and lens base point 126 define a lens thickness "Y".
- lens diameter "X" may be on the order of 5.0 mm.
- lens thickness "Y” may be on the order of 0.25 mm. in thickness.
- a range of sizes and thicknesses may be employed within the scope of the present invention.
- FIGS. 3 and 4 The embodiment of the present invention illustrated in FIGS. 3 and 4 is also contemplated for use in epikeratophakia implants which are placed on, in or under the corneal epithelium for certain conditions requiring optical correction.
- Ophthalmic uses of the material with respect to implants may also include keratoprosthesis.
- Keratoprosthesis is the implantation of an artificial, synthetic cornea in corneal or scleral tissue.
- Intraocular implants were made having a bisphenol A polycarbonate (Lexan) optic lens and polypropylene monofilament haptics.
- intraocular implants Five of the intraocular implants were autoclave sterilized and six intraocular implants were sterilized by ethylene oxide sterilization. No difference in implant behavior was noted for the autoclave sterilized intraocular lenses. The autoclave sterilized intraocular lenses performed satisfactorily.
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- Ophthalmology & Optometry (AREA)
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Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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US07/054,216 US5041133A (en) | 1984-04-11 | 1987-05-26 | Intraocular implant |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US59886184A | 1984-04-11 | 1984-04-11 | |
US88579586A | 1986-07-14 | 1986-07-14 | |
US07/054,216 US5041133A (en) | 1984-04-11 | 1987-05-26 | Intraocular implant |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US88579586A Continuation-In-Part | 1984-04-11 | 1986-07-14 |
Publications (1)
Publication Number | Publication Date |
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US5041133A true US5041133A (en) | 1991-08-20 |
Family
ID=27368593
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US07/054,216 Expired - Lifetime US5041133A (en) | 1984-04-11 | 1987-05-26 | Intraocular implant |
Country Status (1)
Country | Link |
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US (1) | US5041133A (en) |
Cited By (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5250257A (en) * | 1990-06-20 | 1993-10-05 | Adatomed Pharmazeutische Und Medizintechnische Gesellschaft Mbh | Process for the sterilization of implants |
US5342370A (en) * | 1993-03-19 | 1994-08-30 | University Of Miami | Method and apparatus for implanting an artifical meshwork in glaucoma surgery |
US5543442A (en) * | 1993-07-13 | 1996-08-06 | Menicon Co., Ltd. | Ocular lens material |
US5605942A (en) * | 1993-07-13 | 1997-02-25 | Menicon Co., Ltd. | Contact lens material |
US5688264A (en) * | 1992-10-19 | 1997-11-18 | The University Of Miami | Laser treatment for retinal detachment |
US5843186A (en) * | 1996-12-20 | 1998-12-01 | Implemed, Inc. | Intraocular lens with antimicrobial activity |
US6391230B1 (en) | 2000-02-18 | 2002-05-21 | Bausch & Lomb Incorporated | Intraocular lens manufacturing process |
US20030232066A1 (en) * | 1996-12-13 | 2003-12-18 | Ioltechnologie-Production | Intraocular lens containing releasable medication |
US6679605B2 (en) * | 2000-05-22 | 2004-01-20 | Medennium, Inc. | Crystalline polymeric compositions for ophthalmic devices |
US20040204712A1 (en) * | 2003-04-09 | 2004-10-14 | Eric Kolb | Bone fixation plates |
US20040230023A1 (en) * | 2001-11-02 | 2004-11-18 | Salamone Joseph C. | High refractive index aromatic-based silyl monomers |
US20040267274A1 (en) * | 2003-06-27 | 2004-12-30 | Tushar Patel | Tissue retractor and drill guide |
US20050059970A1 (en) * | 2003-09-17 | 2005-03-17 | Eric Kolb | Bone fixation systems |
US20060069434A1 (en) * | 2004-09-30 | 2006-03-30 | Durette Jean-Francois | Quasi-spherical orbital implant |
US20060178572A1 (en) * | 2001-04-27 | 2006-08-10 | March Wayne F | Apparatus for measuring blood glucose concentrations |
US20060184243A1 (en) * | 2004-10-22 | 2006-08-17 | Omer Yilmaz | System and method for aligning an optic with an axis of an eye |
EP1790316A1 (en) * | 2004-06-17 | 2007-05-30 | Zakrytoe Akcionernoe Obschestvo"Nauchno- Proizvodstvenny Complex "Ecoflon" | Cornea reinforcing implant and a keratoprosthesis provided with a plate made of porous polytetrafluorethylene |
US7416553B2 (en) | 2003-04-09 | 2008-08-26 | Depuy Acromed, Inc. | Drill guide and plate inserter |
US7776047B2 (en) | 2003-04-09 | 2010-08-17 | Depuy Spine, Inc. | Guide for spinal tools, implants, and devices |
US7909848B2 (en) | 2003-06-27 | 2011-03-22 | Depuy Spine, Inc. | Tissue retractor and guide device |
US7935123B2 (en) | 2003-04-09 | 2011-05-03 | Depuy Acromed, Inc. | Drill guide with alignment feature |
US7976577B2 (en) | 2005-04-14 | 2011-07-12 | Acufocus, Inc. | Corneal optic formed of degradation resistant polymer |
US8079706B2 (en) | 2003-06-17 | 2011-12-20 | Acufocus, Inc. | Method and apparatus for aligning a mask with the visual axis of an eye |
USD656526S1 (en) | 2009-11-10 | 2012-03-27 | Acufocus, Inc. | Ocular mask |
US8343215B2 (en) | 1999-03-01 | 2013-01-01 | Acufocus, Inc. | System and method for increasing the depth of focus of the human eye |
US8460374B2 (en) | 2003-05-28 | 2013-06-11 | Acufocus, Inc. | Mask configured to maintain nutrient transport without producing visible diffraction patterns |
US9005281B2 (en) | 2009-08-13 | 2015-04-14 | Acufocus, Inc. | Masked intraocular implants and lenses |
US9204962B2 (en) | 2013-03-13 | 2015-12-08 | Acufocus, Inc. | In situ adjustable optical mask |
US9427311B2 (en) | 2009-08-13 | 2016-08-30 | Acufocus, Inc. | Corneal inlay with nutrient transport structures |
US9427922B2 (en) | 2013-03-14 | 2016-08-30 | Acufocus, Inc. | Process for manufacturing an intraocular lens with an embedded mask |
US9545303B2 (en) | 2011-12-02 | 2017-01-17 | Acufocus, Inc. | Ocular mask having selective spectral transmission |
US9943403B2 (en) | 2014-11-19 | 2018-04-17 | Acufocus, Inc. | Fracturable mask for treating presbyopia |
US10004593B2 (en) | 2009-08-13 | 2018-06-26 | Acufocus, Inc. | Intraocular lens with elastic mask |
US10687935B2 (en) | 2015-10-05 | 2020-06-23 | Acufocus, Inc. | Methods of molding intraocular lenses |
US11364110B2 (en) | 2018-05-09 | 2022-06-21 | Acufocus, Inc. | Intraocular implant with removable optic |
US11464625B2 (en) | 2015-11-24 | 2022-10-11 | Acufocus, Inc. | Toric small aperture intraocular lens with extended depth of focus |
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US4681585A (en) * | 1984-04-11 | 1987-07-21 | Intermedics Intraocular, Inc. | Intraocular implant |
Non-Patent Citations (1)
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Cited By (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5250257A (en) * | 1990-06-20 | 1993-10-05 | Adatomed Pharmazeutische Und Medizintechnische Gesellschaft Mbh | Process for the sterilization of implants |
US5688264A (en) * | 1992-10-19 | 1997-11-18 | The University Of Miami | Laser treatment for retinal detachment |
US5651782A (en) * | 1993-03-19 | 1997-07-29 | University Of Miami | Method and apparatus for implanting an artificial meshwork in glaucoma surgery |
US5676679A (en) * | 1993-03-19 | 1997-10-14 | University Of Miami | Apparatus for implanting an artifical meshwork in glaucoma surgery |
US5342370A (en) * | 1993-03-19 | 1994-08-30 | University Of Miami | Method and apparatus for implanting an artifical meshwork in glaucoma surgery |
US5573544A (en) * | 1993-03-19 | 1996-11-12 | University Of Miami | Artificial meshwork filter for glaucoma surgery |
US5543442A (en) * | 1993-07-13 | 1996-08-06 | Menicon Co., Ltd. | Ocular lens material |
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