US4861887A - Herbicidal o-(substituted, aminomethylbenzoic, nicotinic and quinoline-3-carboxylic acids, esters, and salts - Google Patents

Herbicidal o-(substituted, aminomethylbenzoic, nicotinic and quinoline-3-carboxylic acids, esters, and salts Download PDF

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US4861887A
US4861887A US07/148,743 US14874388A US4861887A US 4861887 A US4861887 A US 4861887A US 14874388 A US14874388 A US 14874388A US 4861887 A US4861887 A US 4861887A
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methyl
amino
carbamoyl
sub
dimethylpropyl
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Robert F. Doehner, Jr.
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BASF SE
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American Cyanamid Co
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Priority to US07/148,743 priority Critical patent/US4861887A/en
Priority to EP88119865A priority patent/EP0325730B1/en
Priority to ES88119865T priority patent/ES2054777T3/en
Priority to IL88536A priority patent/IL88536A/en
Priority to AT88119865T priority patent/ATE107288T1/en
Priority to DE3850240T priority patent/DE3850240T2/en
Priority to IL10346188A priority patent/IL103461A/en
Priority to JP1013331A priority patent/JP2825517B2/en
Priority to CA000589101A priority patent/CA1338248C/en
Priority to HU89316A priority patent/HU205915B/en
Priority to AU28787/89A priority patent/AU618062B2/en
Priority to DK034089A priority patent/DK34089A/en
Priority to ZA89643A priority patent/ZA89643B/en
Priority to KR1019890000811A priority patent/KR0130975B1/en
Priority to IE23189A priority patent/IE64510B1/en
Priority to BR898900317A priority patent/BR8900317A/en
Priority to US07/373,438 priority patent/US4959476A/en
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Priority to US07/715,290 priority patent/US5103009A/en
Priority to IL103461A priority patent/IL103461A0/en
Priority to DK050693A priority patent/DK50693A/en
Priority to DK050793A priority patent/DK50793A/en
Priority to KR1019970047551A priority patent/KR0134906B1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Definitions

  • This invention pertains to imidazolinone compounds and particularly to methods and intermediates useful for the preparation of o-carboxyarylimidazolinone compounds which are useful as herbicides.
  • Novel herbicidal imidazolinyl benzoic acids, nicotinic acids and quinoline-3-carboxylic acids, esters, and salts, and their preparation and use are disclosed in U.S. Pat. Nos. 4,188,487, 4,297,128, and 4,638,068.
  • the present invention provides a method for the preparation of o-carboxyarylimidazolinone compounds by oxidizing the appropriate 2- ⁇ [(1-carbamoyl-1,2-dimethylpropyl)amino]methyl ⁇ benzoic acid, nicotinic acid or quinoline-3-carboxylic acid with a brominating agent.
  • the invention also provides a method for preparing the intermediate 2- ⁇ [(1-carbamoyl-1,2-dimethylpropyl)amino]methyl ⁇ compounds by alkylating 2-methylvalineamides with the appropriate o-halomethylarylcarboxylate.
  • a 2-chloro-4-halo acetoacetate ester is reacted with an ⁇ , ⁇ -unsaturated aldehyde or ketone to form a 2-(halomethyl)nicotinic ester.
  • the invention further provides certain 2- ⁇ [(1-carbamoyl-1,2-dimethylpropyl)amino]methyl ⁇ benzoic acid, nicotinic acid, or quinoline-3-carboxylic acid compounds and certain 2-(halomethyl)benzoic esters, nicotinic esters, a quinoline-3-carboxylic ester compound useful as intermediates in the above methods.
  • the invention also provides a method for the preparation of o-carboxypyridyl imidazoline compounds by a sequence proceeding from the 2-chloro-4-haloacetoacetates, through reactions as described above, to oxidation of 2- ⁇ [(1-carbamoyl-1,2-dimethylpropyl)amino]-methyl ⁇ nicotinic acid ester with a brominating agent.
  • the oxidation method of this invention based on use of a bromine source provides unexpected results.
  • Other oxidizing agents such as sulfur, chlorine, iodine and manganese oxide were ineffective for the result desired.
  • A is CH or N
  • R 1 is H or C 1 -C 12 alkyl
  • R 2 is H or C 1 -C 6 alkyl
  • R 3 is H, C 1 -C 6 alkyl, or when R 2 and R 3 are taken together they may form a ring represented by
  • the present invention includes novel compounds represented by formula II below ##STR5## wherein
  • A is CH or N
  • R 1 is H or C 1 -C 12 alkyl
  • R 2 is H or C 1 -C 6 alkyl
  • a preferred group of novel formula II and formula III compounds above are those wherein
  • R 1 is C 1 -C 3 alkyl
  • R 2 is H, or C 1 -C 3 alkyl
  • R 3 is H.
  • Formula III pyridine halomethyl compounds for use in the method of this invenion may be prepared by a method analogous to that described in pending application for U.S. Letters Patent of R. Doehner, Ser. No. 791,671 filed Oct.
  • the present invention also includes a method for the preparation of o-carboxypyridyl imidazolinone compounds represented by formula I ##STR10## wherein
  • R 1 is H, or C 1 -C 12 alkyl
  • R 2 is H, or C 1 -C 6 alkyl
  • R 3 is H
  • This material is purified by extraction into aqueous hydrochloric acid, washing with hexanes, making the aqueous phase basic with cold ammonium hydroxide, and extracting with hexanes to afford 30 g of the title product as an oil (43%), having elemental analysis calculated for C 11 H 14 ClNO 2 %C 58.03, H 6.20, N 6.15, Cl 15.57 found %C 58.29, H 6.30, N 6.02, Cl 15.49.
  • the organic layer is washed with aqueous sodium bisulfite, dried over MgSO 4 , diluted with an equal volume of hexanes, and filter-chromatographed through a pad of silica gel.
  • the silica gel is further eluted with additional 1:1 hexane-ethyl acetate, and the combined eluates are concentrated in vacuo to afford 0.6 g product having mp 84.5°-86.5° C.
  • the title product is also obtained using N-bromoacetamide or N-bromosuccinimide in place of bromine.

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

A method for the preparation of o-carboxyl imidazolinone compounds including oxidizing the appropriate 2-{[(1-carbamoyl-1,2-dimethylpropyl)amino]methyl}-benzoic acid intermediate with a brominating agent. Compounds useful as intermediates in the oxidation method and methods for preparing them are disclosed.

Description

BACKGROUND OF THE INVENTION
This invention pertains to imidazolinone compounds and particularly to methods and intermediates useful for the preparation of o-carboxyarylimidazolinone compounds which are useful as herbicides.
Novel herbicidal imidazolinyl benzoic acids, nicotinic acids and quinoline-3-carboxylic acids, esters, and salts, and their preparation and use are disclosed in U.S. Pat. Nos. 4,188,487, 4,297,128, and 4,638,068.
SUMMARY OF THE INVENTION
The present invention provides a method for the preparation of o-carboxyarylimidazolinone compounds by oxidizing the appropriate 2-{[(1-carbamoyl-1,2-dimethylpropyl)amino]methyl}benzoic acid, nicotinic acid or quinoline-3-carboxylic acid with a brominating agent.
The invention also provides a method for preparing the intermediate 2-{[(1-carbamoyl-1,2-dimethylpropyl)amino]methyl} compounds by alkylating 2-methylvalineamides with the appropriate o-halomethylarylcarboxylate. In the case of pyridine halomethyl compounds, a 2-chloro-4-halo acetoacetate ester is reacted with an α,β-unsaturated aldehyde or ketone to form a 2-(halomethyl)nicotinic ester.
The invention further provides certain 2-{[(1-carbamoyl-1,2-dimethylpropyl)amino]methyl}benzoic acid, nicotinic acid, or quinoline-3-carboxylic acid compounds and certain 2-(halomethyl)benzoic esters, nicotinic esters, a quinoline-3-carboxylic ester compound useful as intermediates in the above methods.
The invention also provides a method for the preparation of o-carboxypyridyl imidazoline compounds by a sequence proceeding from the 2-chloro-4-haloacetoacetates, through reactions as described above, to oxidation of 2-{[(1-carbamoyl-1,2-dimethylpropyl)amino]-methyl} nicotinic acid ester with a brominating agent.
The oxidation method of this invention based on use of a bromine source provides unexpected results. Other oxidizing agents such as sulfur, chlorine, iodine and manganese oxide were ineffective for the result desired.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
o-Carboxyaryl imidazolinone compounds represented by formula I ##STR1## wherein
A is CH or N;
R1 is H or C1 -C12 alkyl;
R2 is H or C1 -C6 alkyl;
R3 is H, C1 -C6 alkyl, or when R2 and R3 are taken together they may form a ring represented by
--CH═C--CH═CH--;
are prepared by reacting a 2-{[(1-carbamoyl-1,2-dimethylpropyl)amino]methyl} nicotinic acid, or quinoline-3-carboxylic acid of formula II ##STR2## wherein A, R1, R2, and R3 are as described for formula I above with a minimum of two molar equivalents of a brominating agent such as bromine, N-bromosuccinimide, N-bromoacetamide or the like in an inert organic solvent, such as acetic acid, in the presence of an acid acceptor such as sodium acetate, in a temperature range of about 20° C. to 100° C. for a sufficient period of time to essentially complete the reaction as illustrated in Flow Diagram I below. ##STR3## Formula II 2-{[(1-carbamoyl-1,2-dimethylpropyl)amino]-methyl} compounds suitable for use in the method of this invention may be prepared by reacting a 2-(halomethyl)-benzoic ester, nicotinic ester, or quinoline-3-carboxylic ester of formula III wherein R1 is C1 -C12 alkyl and A, R2, and R3 are as described for formula I above; and X is Cl or Br; with a minimum of one molar equivalent of racemic 2-amino-2,3-dimethylbutyramide or an individual optical isomer thereof, in an inert organic solvent such as dimethylsulfoxide, acetone or the like; in the presence of a base such as sodium bicarbonate; optionally in the presence of a catalytic amount of NaI; in a temperature range of about 25° C. to 100° C. as illustrated in flow diagram II below. ##STR4## Formula II compounds wherein R1 is hydrogen which are suitable for use in the method of this invention may readily be prepared from compounds of formula II wherein R1 is C1 -C12 alkyl by hydrolysis.
The present invention includes novel compounds represented by formula II below ##STR5## wherein
A is CH or N;
R1 is H or C1 -C12 alkyl;
R2 is H or C1 -C6 alkyl
R3 is H, C1 -C6 alkyl, or when R2 and R3 are taken together they may form a ring represented by --CH═CH--CH═CH--; and novel compounds by formula III below ##STR6## wherein R1 =C1 -C12 alkyl and R2 and R3 are described for formula II above, and X is Cl or Br, which are useful intermediates for the preparation of herbicidal imidazolinone compounds utilizing the methods of this invention. A preferred group of novel formula II and formula III compounds above are those wherein
R1 is C1 -C3 alkyl;
R2 is H, or C1 -C3 alkyl; and
R3 is H.
Formula III pyridine halomethyl compounds for use in the method of this invenion may be prepared by a method analogous to that described in pending application for U.S. Letters Patent of R. Doehner, Ser. No. 791,671 filed Oct. 28, 1985 by reacting a 2-chloro-4-haloacetoacetate ester of formula IV ##STR7## wherein R1 is C1 -C12 alkyl; and X is Cl or Br with an α, β-unsaturated aldehyde or ketone of formula V ##STR8## wherein R2 is H or C1 -C6 alkyl and R3 is H in the presence of a minimum of two molar equivalents of ammonium salt in an organic solvent, in a temperature range of ambient temperature to the boiling point of the solvent until the reaction is essentially complete, as illustrated in Flow Diagram III below. ##STR9## wherein R1, R2, R3 and X are as described for formula IV and Formula V above.
The present invention also includes a method for the preparation of o-carboxypyridyl imidazolinone compounds represented by formula I ##STR10## wherein
R1 is H, or C1 -C12 alkyl;
R2 is H, or C1 -C6 alkyl; and
R3 is H;
by reacting, in sequence, a 2-chloro-4-haloacetoacetate ester of formula IV ##STR11## with an α,β-unsaturated aldehyde or ketone of formula V ##STR12## in the presence of a minimum of two molar equivalents of ammonium salt in an organic solvent, in a temperature range of ambient temperature to the boiling point of the solvent until the reaction is essentially complete, and reacting the thus formed 2-(halomethyl)nicotinic ester, of formula III ##STR13## wherein R1, R2, R3 and X are as previously described for formula IV and V, with a minimum of one molar equivalent of racemic 2-amino-2,3-dimethylbutyramide or an individual optical isomer thereof in an inert organic solvent in the presence of a base, optionally in the presence of a catalytic amount of NaI, in a temperature range of about 25° C. to 100° C., and further reacting the thus-formed 2-{[(1-carbamoyl-1,2-dimethylpropyl)amino]methyl}nicotinic ester, or acid derived therefrom, of formula II ##STR14## wherein R1, R2 and R3, are as described for formula I above with a minimum of two molar equivalents of a brominating agent in an inert organic solvent in the presence of an acid acceptor in a temperature range of about 25° C. to 100° C. for a sufficient period of time to essentially complete the reaction.
The preparation of other intermediates of formula III closely follows literature procedures such as oxidation of a 2-methyl-3-pyridinecarboxylate or a 2-methyl-3-quinolinecarboxylate, followed by rearrangement of the resulting N-oxide with POCl3, to give compounds of formula III as illustrated below. ##STR15##
The invention is further illustrated by the following non-limiting examples.
EXAMPLE 1 Preparation of ethyl 2-chloromethyl-5-ethylnicotinate
A solution of 61 g of ethyl-2,4-dichloroacetoacetate (0.306 mol) and 30 g of 2-ethylacrolein (0.357 mol) in 500 mL of absolute ethanol is mixed with 85.5 g of ammonium sulfamate (0.75 mol), and the stirred mixture is heated at reflux for 90 minutes. The reaction is concentrated in vacuo and the residue is partitioned between ethyl acetate and water. The organic phase is concentrated in vacuo, and the residue is chromatographed on silica gel using hexane-ethyl acetate mixtures to give 50 g of crude product. This material is purified by extraction into aqueous hydrochloric acid, washing with hexanes, making the aqueous phase basic with cold ammonium hydroxide, and extracting with hexanes to afford 30 g of the title product as an oil (43%), having elemental analysis calculated for C11 H14 ClNO2 %C 58.03, H 6.20, N 6.15, Cl 15.57 found %C 58.29, H 6.30, N 6.02, Cl 15.49.
Utilizing the above procedure yields the formula III compounds listed in Table I below.
              TABLE I                                                     
______________________________________                                    
 ##STR16##                    (III)                                       
mp       R.sub.1 R.sub.2 R.sub.3                                          
                              X    analysis (calc)                        
______________________________________                                    
low-melting                                                               
         C.sub.2 H.sub.5                                                  
                 CH3     H    Cl   C,  56.13                              
                                            (56.22)                       
solid                              H,  5.65 (5.66)                        
                                   N,  6.57 (6.56)                        
                                   Cl, 16.40                              
                                            (16.59)                       
oil      CH.sub.3                                                         
                 C.sub.2 H.sub.5                                          
                         H    Cl   C,  55.68                              
                                            (56.22)                       
                                   H,  5.63 (5.66)                        
                                   N,  6.25 (6.56)                        
                                   Cl, 16.70                              
                                            (16.59)                       
low-melting                                                               
         CH.sub.3                                                         
                 CH3     H    Cl   C,  54.12                              
                                            (54.15)                       
                                   H,  5.07 (5.05)                        
                                   N,  6.98 (7.02)                        
                                   Cl, 17.79                              
                                            (17.76)                       
low-melting                                                               
         C.sub.2 H.sub.5                                                  
                 CH.sub.3                                                 
                         H    Br   C,  47.86                              
                                            (46.53)                       
                                   H,  4.75 (4.69)                        
                                   N,  5.51 (5.43)                        
                                   Br, 31.28                              
                                            (30.96)                       
______________________________________
EXAMPLE 2 Preparation of ethyl 2-chloromethylnicotinate
A solution of 9 g of ethyl 2-methylnicotinate in 250 mL methylene chloride is stirred at room temperature and 32 g of 80% metachloroperoxybenzoic acid is added in one portion. The resulting solution is stirred for three days. The precipitated solid is filtered off, and the filtrate is washed with cold, dilute aqueous sodium hydroxide, dried, and concentrated in vacuo to afford the crude N-oxide. This material is digested in 75 mL of 1,2-dichloroethane; 15 mL of phosphorous oxychloride is added, and the solution is heated at reflux overnight. The solution is concentrated in vacuo, and the residue is taken up in methylene chloride and neutralized with aqueous sodium acetate. The organic phase is dried, concentrated in vacuo, and the residue is chromatographed on silica gel using hexane-ethyl acetate mixtures to afford 1.2 g of the title product as an oil having
NMRδmCDCl(3): 1.4 (+, 3H), 4.5 (q, 2H), 5.1 (2H), 7.4 (1,H), 8.4 (dd, 1H), 8.8 (dd, 1H).
Also prepared by this method is ethyl 2-chloromethylquinoline-3-carboxylate; NMR(δCDCl3) 1.4 (+, 3H), 4.5 (q, 2H), 5.3 (5,2H), 7.5-8.3 (m, 4H), 9.0 (5, 1H).
EXAMPLE 3 Preparation of ethyl 2-{[(1-carbamoyl-1,2-dimethylpropyl)amino]methyl}-5-ethylnicotinate
A mixture of 77 g of ethyl 2-chloromethyl-5-ethylnicotinate (0.338 mol), 44 g of o-methylvalinamide (0.338 mol) and 33.5 g of sodium bicarbonate (0.4 mol) in 60 mL dimethylsulfoxide is stirred and heated at 80° for 16 hours. The reaction is partitioned between 1:1 ethylacetate-hexane and water. The organic layer is washed thoroughly with water, dried, and concentrated in vacuo to a gum. Chromatography of this gum on silica gel using hexane-ethyl acetate mixtures as eluant affords the title product, mp 68-72°.
The above reaction is conducted with acetone as solvent (with cat. NaI) and also yields the title product.
Utilizing the above procedure with analogous formula III halomethyl compounds yields the formula II compounds listed in Table II below.
              TABLE II                                                    
______________________________________                                    
 ##STR17##                    (II)                                        
mp °C.                                                             
         R1     R2           R.sub.3 A                                    
______________________________________                                    
106-107  CH.sub.3                                                         
                CH.sub.3     H       N                                    
solid    C.sub.2 H.sub.5                                                  
                H            H       N                                    
138-139  C.sub.2 H.sub.5                                                  
                CHCHCHCH           N                                      
81-83    C.sub.2 H.sub.5                                                  
                H            H       CH                                   
______________________________________
EXAMPLE 4 Preparation of ethyl 5-ethyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinate
A mixture of 1 g of ethyl 2-{[(1-carbamoyl-1,2-dimethylpropyl)amino]methyl}-5-ethylnicotinate (3.1 mmol) and 0.58 g anhydrous sodium acetate (7 mmol) in 10 mL acetic acid is warmed to 50° C., at which point the reaction is a homogeneous solution. A solution 1 g of bromine (6.2 mmol) in 2 mL acetic acid is added in two portions over two minutes, and the reaction is stirred at 50° C. for 16 hours. The reaction mixture is concentrated in vacuo, and the residue is partitioned between ethyl acetate and water. The organic layer is washed with aqueous sodium bisulfite, dried over MgSO4, diluted with an equal volume of hexanes, and filter-chromatographed through a pad of silica gel. The silica gel is further eluted with additional 1:1 hexane-ethyl acetate, and the combined eluates are concentrated in vacuo to afford 0.6 g product having mp 84.5°-86.5° C.
The title product is also obtained using N-bromoacetamide or N-bromosuccinimide in place of bromine.
Utilizing the above procedure with various formula II compounds yields the formula I compounds listed in Table III below.
              TABLE III                                                   
______________________________________                                    
 ##STR18##                     (I)                                        
R.sub.1                                                                   
       R.sub.2    R.sub.3   A      mp °C.                          
______________________________________                                    
CH.sub.3                                                                  
       CH.sub.3   H         N      129.0-130.5                            
C.sub.2 H.sub.5                                                           
       H          H         N      72.0-75.0                              
C.sub.2 H.sub.5                                                           
       CHCHCHCH         N        146.0-147.5                              
H      H          H         CH     163.0-165.0                            
______________________________________
EXAMPLE 5 Preparation of 2-{[(1-carbamoyl-1,2-dimethylpropyl)amino]methyl}-5-ethylnicotinic acid
A solution of 5.6 g of ethyl 2-{[(1-carbamoyl-1,2-dimethylpropyl)amino]methyl}-5-ethylnicotinate (0.0174 mol) in 30 mL of methanol containing 2 g of NaOH (0.05 mol) and 10 mL water is stirred at room temperature for two hours and 30 minutes. The reaction is concentrated in vacuo and redissolved in 30 mL water; adjustment of the pH to 4 with concentrated hydrochloric acid and concentration in vacuo gives a gum. This residue is dissolved in a mixture of ethyl acetate, tetrahydrofuran, and methanol, dried over MgSO4, and concentrated in vacuo to 6 g foam. Crystallization from methanol-ether affords 3.1 g product, mp 180°-181° C.
EXAMPLE 6 Preparation of 5-ethyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid
A mixture of 0.8 g of 2-{[(1-carbamoyl-1,2-dimethylpropyl)amino]methyl}-5-ethylnicotinic acid (2.7 mmol) and 0.56 g sodium acerate (6.8 mmol) in 10 mL acetic acid is warmed until homogeneous and cooled to room temperature. The solution is treated with 0.88 g bromine (5.45 mmol), and the reaction is stirred at 25° C. for 16 hours, then at 75° C. for three days. The reaction mixture is partitioned between CH2 Cl2 and water, and the organic phase is dried and concentrated in vacuo. The residue is recrystallized from ethyl acetate-hexanes to afford 0.4 g of the title product having mp 172°-175° C.

Claims (8)

What is claimed is:
1. A 2-{[(1-carbamoyl-1,2-dimethylpropyl)-amino]methyl}benzoic acid, nicotinic acid or quinoline-3-carboxylic acid compound represented by formula II ##STR19## wherein A is CH, or N;
R1 is H or C1 -C12 alkyl;
R2 is H or C1 -C6 alkyl;
R3 is H, C1 -C6 alkyl, or when R2 and R3 are
taken together they may form a ring represented by
--CH═CH--CH═CH--.
2. A compound according to claim 1 wherein
R1 is H or C1 -C3 alkyl;
R2 is H or C1 -C3 alkyl; and
R3 is H.
3. The compound according to claim 1 wherein the compound is ethyl 2-{[(1-carbamoyl-1,2-dimethylpropyl)amino]methyl}benzoate.
4. The compound according to claim 1 wherein the compound is ethyl 2-{[(1-carbamoyl-1,2-dimethylpropyl)amino]methyl}-5-ethylnicotinate.
5. The compound according to claim 1 wherein the compound is methyl 2-{[(1-carbamoyl-1,2-dimethylpropyl)amino]methyl}-5-methylnicotinate.
6. The compound according to claim 1 wherein the compound is ethyl 2-{[(1-carbamoyl-1,2-dimethylpropyl)amino]methyl}nicotinate.
7. The compound according to claim 1 wherein the compound is ethyl 2-{[(1-carbamoyl-1,2-dimethylpropyl)amino]methyl}-3-quinolinecarboxylate.
8. The compound according to claim 1 wherein the compound is 2-{[(1-carbamoyl-1,2-dimethypropyl)amino]methyl}-5-ethylnicotinic acid.
US07/148,743 1988-01-27 1988-01-27 Herbicidal o-(substituted, aminomethylbenzoic, nicotinic and quinoline-3-carboxylic acids, esters, and salts Expired - Lifetime US4861887A (en)

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US07/148,743 US4861887A (en) 1988-01-27 1988-01-27 Herbicidal o-(substituted, aminomethylbenzoic, nicotinic and quinoline-3-carboxylic acids, esters, and salts
EP88119865A EP0325730B1 (en) 1988-01-27 1988-11-29 Method for the preparation of O-carboxyarylimindazolinones
ES88119865T ES2054777T3 (en) 1988-01-27 1988-11-29 METHOD FOR THE PREPARATION OF O-CARBOXYARILIMIDAZOLINONES.
IL88536A IL88536A (en) 1988-01-27 1988-11-29 Process for the preparation of herbicidal o-carboxylaryl- imidazolinones, and novel intermediates thereof
AT88119865T ATE107288T1 (en) 1988-01-27 1988-11-29 PROCESS FOR THE PREPARATION OF O-CARBOXYARYLIMIDAZOLINONES.
DE3850240T DE3850240T2 (en) 1988-01-27 1988-11-29 Process for the preparation of O-carboxyarylimidazolinones.
IL10346188A IL103461A (en) 1988-01-27 1988-11-29 2-(Halomethyl.) nicotinic esters and 2-(halogethyl) benzoic esters useful as intermediates in the preparation of herbicidal compounds
JP1013331A JP2825517B2 (en) 1988-01-27 1989-01-24 Method for producing herbicidal O-carboxyali-loumidazolinones
CA000589101A CA1338248C (en) 1988-01-27 1989-01-25 Method for the preparation of o-carboxyarylimidazolinones
HU89316A HU205915B (en) 1988-01-27 1989-01-25 Process for producing herbicide ortho-carboxy-aryl-imidazolinone derivatives
AU28787/89A AU618062B2 (en) 1988-01-27 1989-01-25 Method for the preparation of o-carboxyarylimidazolinones
BR898900317A BR8900317A (en) 1988-01-27 1989-01-26 PROCESS FOR THE PREPARATION OF HERBICIDIC COMPOUNDS AND HERBICIDIC COMPOUNDS
DK034089A DK34089A (en) 1988-01-27 1989-01-26 METHODS AND INTERMEDIATES FOR THE PREPARATION OF HERBICIDE O-CARBOXYARYLIMIDAZOLINONES
ZA89643A ZA89643B (en) 1988-01-27 1989-01-26 Method for the preparation of o-carboxyarylimidazolinones
KR1019890000811A KR0130975B1 (en) 1988-01-27 1989-01-26 Method for the preparation of herbicidal o-carboxyarylimidazolinone compounds
IE23189A IE64510B1 (en) 1988-01-27 1989-01-26 Method for the preparation of herbicidal o-carboxyarylimidazolinones
US07/373,438 US4959476A (en) 1988-01-27 1989-06-30 Method for the preparation of herbicidal O-carboxyarylimidazolinones
US07/554,035 US5034532A (en) 1988-01-27 1990-07-16 Method for the preparation of quinolyl and pyridyl substituted imidazolinones
US07/715,290 US5103009A (en) 1988-01-27 1991-06-14 Method for the preparation of herbicidal intermediates
IL103461A IL103461A0 (en) 1988-01-27 1992-10-18 Process for the preparation of herbicidal o-carboxyarylimidazolinones,and novel intermediates thereof
DK050693A DK50693A (en) 1988-01-27 1993-05-04 METHOD AND EXITING PUBLIC FOR THE PREPARATION OF 2- (OE (1-CARBAMOYL-1,2-DIMETHYLPROPYL) -AMINOAA-METHYL) -BENZOIC ACID, -NICOTINIC ACID, AND QUINOLINE-3-CARBOXYL
DK050793A DK50793A (en) 1988-01-27 1993-05-04 METHOD OF PREPARING HERBICIDE O-CARBOXYPYRIDYLIMIDAZOLINONES
KR1019970047551A KR0134906B1 (en) 1988-01-27 1997-09-18 Intermediates of o-carboxyarylimidazolinone compounds useful as herbicides and methods for their preparation

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US07/148,743 US4861887A (en) 1988-01-27 1988-01-27 Herbicidal o-(substituted, aminomethylbenzoic, nicotinic and quinoline-3-carboxylic acids, esters, and salts

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CA (1) CA1338248C (en)
DE (1) DE3850240T2 (en)
DK (3) DK34089A (en)
ES (1) ES2054777T3 (en)
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CN102844302A (en) * 2010-04-06 2012-12-26 日本曹达株式会社 Nitrogen-containing heterocyclic compound and method for producing same

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ATE166350T1 (en) * 1989-12-27 1998-06-15 American Cyanamid Co ALKYL ESTERS OF 5-HETEROCYCLIC-PYRIDINE-2,3-DICARBONONIC ACIDS AND 5-HETEROCYCLIC-2-(2-IMIDAZOLINE-2-YL)PYRIDINES AND METHOD FOR THE PRODUCTION THEREOF
KR920003063B1 (en) * 1990-02-28 1992-04-13 재단법인 한국화학연구소 Novel-2(2-imidazolinc-2yl)-3-(amino oxoacetyl)-pyridine derivatives and its salt
EP0511446A3 (en) * 1991-04-29 1993-04-28 Hoechst Celanese Corporation Process for preparing pyridinecarboxylic acid derivatives
JP2001081080A (en) * 1999-09-14 2001-03-27 Nissan Chem Ind Ltd Production of 4(5)-chloromethyl-2-phenyl-1,2,3-triazole derivative
AU2014201038B2 (en) * 2010-04-06 2015-08-06 Nippon Soda Co., Ltd. Nitrogen-containing heterocyclic compound and method for producing same

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DE3850240T2 (en) 1995-02-02
AU2878789A (en) 1989-07-27
EP0325730A3 (en) 1991-02-13
EP0325730B1 (en) 1994-06-15
ATE107288T1 (en) 1994-07-15
ZA89643B (en) 1989-10-25
IL88536A (en) 1993-02-21
CA1338248C (en) 1996-04-16
DK50793D0 (en) 1993-05-04
AU618062B2 (en) 1991-12-12
KR0130975B1 (en) 1998-04-16
IL88536A0 (en) 1989-06-30
DE3850240D1 (en) 1994-07-21
JP2825517B2 (en) 1998-11-18
BR8900317A (en) 1989-09-19
DK34089A (en) 1989-07-28
DK50693D0 (en) 1993-05-04
DK50693A (en) 1993-05-04
DK34089D0 (en) 1989-01-26
ES2054777T3 (en) 1994-08-16
DK50793A (en) 1993-05-04
HU205915B (en) 1992-07-28
IE890231L (en) 1989-07-27
JPH01224364A (en) 1989-09-07
IL103461A (en) 1994-06-24
HUT50133A (en) 1989-12-28
KR890011873A (en) 1989-08-23
EP0325730A2 (en) 1989-08-02
IE64510B1 (en) 1995-08-09

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