US4708867A - Minipellets - Google Patents
Minipellets Download PDFInfo
- Publication number
- US4708867A US4708867A US06/587,536 US58753684A US4708867A US 4708867 A US4708867 A US 4708867A US 58753684 A US58753684 A US 58753684A US 4708867 A US4708867 A US 4708867A
- Authority
- US
- United States
- Prior art keywords
- prednisone
- prednisolone
- minipellets
- dosage form
- minipellet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
Definitions
- the present invention relates to an improved dosage form for prednisone or prednisolone. More particularly, it relates to minipellets coated to mask the unpleasant taste of those compounds.
- Prednisone, 17 ⁇ , 21-dihydroxypregna-1,4-diene-3,11,20-trione, also named 1,4-pregnadiene-17 ⁇ , 21-diol-3,11,20-trione, and prednisolone, also named of 11 ⁇ ,17,21-trihydroxypregna-1,4-diene-3,20-dione, are well known adrenocortical steroids. They are available as 1 to 50 mg tablets; and the usual oral dose is from 5 to 50 mg per day. Both are described as having a very bitter taste, unpleasant to adults and particularly unpleasant to children.
- prednisone or prednisolone While it is possible to administer prednisone or prednisolone in a conventional gelatin capsule, children are often unwilling to swallow capsules and older adults may be unable to swallow them. Accordingly, it would be desirable to provide these medicaments in minipellet form coated to mask their unpleasant taste.
- the United States Pharmacopeia requires that dosage forms containing prednisone or prednisolone be almost completely dissolved within 30 minutes after administration; prednisone or prednisolone coated with the usual tablet coatings would not meet that test.
- the present invention provides a prednisone or prednisolone minipellet which, when ingested, does not exhibit a bitter taste in the mouth but is rapidly dissolved in the stomach.
- the present invention is a minipellet comprising prednisone or prednisolone admixed with polyvinylpyrrolidone coated on a nonpareil seed, and further coated with a copolymer of dimethylaminoethyl and methyl methacrylate.
- the present invention is a minipellet dosage form of prednisone or prednisolene resistant to attack by saliva but readily dissolvable in gastric juice which comprises a mixture of prednisone or prednisolone and polyvinylpyrrolidone coated onto a nonpareil seed, and further coated with a copolymer of dimethylaminoethyl and methyl methacrylate.
- the invention contemplates a unit dosage of said minipellets in a readily opened container such as an unsealed capsule.
- the copolymer utilized in practicing the present invention is a cationic copolymer available under the trade name Eudragit E 100. That copolymer forms a coating resistant to saliva and effectively masks any unpleasant taste in the mouth, but becomes water soluble in the stomach very quickly by forming a salt with the hydrochloric acid present in the gastric juice.
- micronized prednisone or prednisolone is suspended in a solution of polyvinylpyrrolidone dissolved in a suitable organic solvent, preferably isopropyl alcohol.
- a suitable organic solvent preferably isopropyl alcohol.
- the suspension and/or solution is coated onto nonpareil sugar seeds, preferably 30-60 mesh in size, using conventional equipment.
- the minipellets coated with prednisone or prednisolone and polyvinylpyrrolidone are further coated with an organic solvent solution of dimethylaminoethyl and methyl methacrylate.
- the addition of separation substances decreases the tendency of the polymer to agglutinate and produces a more uniform surface on the resultant minipellet.
- an appropriate number of minipellets are placed in a capsule to provide the desired dosage.
- the capsule should be readily openable by an elderly person to avoid unintentional spilling and loss of minipellets. Typically, the capsule is opened just before use and the minipellets sprinkled onto a food which is then eaten as part of a meal or snack.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
TABLE __________________________________________________________________________ Time in Beef Chicken Pudding Vegetable Apple Pear Minutes 5 10 5 10 5 10 26 5 10 2 4 5 2 4 5 __________________________________________________________________________ I O T O O O O O O O O O T O O T II O O O O O O O O O O O T O O T III O O O O O O O O O O O T O O T IV O O O O O O O O O O O T O O T __________________________________________________________________________ O indicates no taste detected T indicates taste detected
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/587,536 US4708867A (en) | 1983-12-19 | 1984-03-08 | Minipellets |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56485283A | 1983-12-19 | 1983-12-19 | |
US06/587,536 US4708867A (en) | 1983-12-19 | 1984-03-08 | Minipellets |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US56485283A Continuation-In-Part | 1983-12-19 | 1983-12-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
US4708867A true US4708867A (en) | 1987-11-24 |
Family
ID=27073677
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US06/587,536 Expired - Fee Related US4708867A (en) | 1983-12-19 | 1984-03-08 | Minipellets |
Country Status (1)
Country | Link |
---|---|
US (1) | US4708867A (en) |
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4971791A (en) * | 1985-08-26 | 1990-11-20 | The Procter & Gamble Company | Taste masking compositions |
WO1991001734A1 (en) * | 1989-07-26 | 1991-02-21 | Himedics, Inc. | Prednisone microencapsulated granules |
US5213811A (en) * | 1991-09-13 | 1993-05-25 | Sterling Drug Inc. | Oral sustained-release drug compositions |
US5328697A (en) * | 1992-02-10 | 1994-07-12 | Mallinckrodt Veterinary, Inc. | Compositions and processes for the sustained release of drugs |
US5643602A (en) * | 1989-11-22 | 1997-07-01 | Astra Aktiebolag | Oral composition for the treatment of inflammatory bowel disease |
US6153220A (en) * | 1997-10-03 | 2000-11-28 | Elan Corporation, Plc | Taste-masked formulations |
US6423340B1 (en) | 1989-11-22 | 2002-07-23 | Aktiebolaget Draco | Method for the treatment of inflammatory bowel diseases |
WO2003075895A1 (en) * | 2002-03-11 | 2003-09-18 | Novartis Ag | Tasted masked veterinary solid compositions |
US20030215500A1 (en) * | 1996-06-14 | 2003-11-20 | Motohiro Ohta | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
WO2004022037A1 (en) * | 2002-09-04 | 2004-03-18 | Ranbaxy Laboratories Limited | Taste masked dosage forms and processes for their preparation |
US20040191918A1 (en) * | 2003-03-28 | 2004-09-30 | Sandrine Isz | Evaluation of bitterness of active drugs |
US20060105039A1 (en) * | 2004-10-21 | 2006-05-18 | Jin-Wang Lai | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
US20060105038A1 (en) * | 2004-11-12 | 2006-05-18 | Eurand Pharmaceuticals Limited | Taste-masked pharmaceutical compositions prepared by coacervation |
US20060127479A1 (en) * | 2004-10-08 | 2006-06-15 | Natrajan Kumaraperumal | Solvent free taste masked pharmaceutical compositions |
EP1759692A2 (en) * | 2003-03-10 | 2007-03-07 | Novartis AG | Taste-masked solid veterinary compositions |
WO2007126136A2 (en) * | 2006-04-27 | 2007-11-08 | Takeda Pharmaceutical Company Limited | Mask- tasting solid preparation of pioglitazone |
EP2398470A1 (en) * | 2009-02-23 | 2011-12-28 | Eurand, Inc. | Controlled-release compositions comprising a proton pump inhibitor |
US8367111B2 (en) | 2002-12-31 | 2013-02-05 | Aptalis Pharmatech, Inc. | Extended release dosage forms of propranolol hydrochloride |
US8580313B2 (en) | 2009-12-02 | 2013-11-12 | Aptalis Pharma Limited | Fexofenadine microcapsules and compositions containing them |
US8747895B2 (en) | 2004-09-13 | 2014-06-10 | Aptalis Pharmatech, Inc. | Orally disintegrating tablets of atomoxetine |
US9040086B2 (en) | 2001-10-04 | 2015-05-26 | Aptalis Pharmatech, Inc. | Timed, sustained release systems for propranolol |
US9161919B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
US9884014B2 (en) | 2004-10-12 | 2018-02-06 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
US9974752B2 (en) | 2014-10-31 | 2018-05-22 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3775537A (en) * | 1970-06-27 | 1973-11-27 | Roehm Gmbh | Copolymer coatings for pharmaceuticals |
US3959540A (en) * | 1973-08-08 | 1976-05-25 | R.P. Scherer Gmbh | Gastric juice resistant gelatin capsules and a process for the production thereof |
US4101651A (en) * | 1975-09-29 | 1978-07-18 | Meiji Seika Kaisha, Ltd. | Process for preparing preparations for oral administration |
US4150110A (en) * | 1976-05-14 | 1979-04-17 | Nippon Kayaku Kabushiki Kaisha | Coated granules of polyacrylic alkali metal salts and method of producing same |
US4341759A (en) * | 1975-11-17 | 1982-07-27 | Aktiebolaget Hassle | Granule having controlled release properties |
-
1984
- 1984-03-08 US US06/587,536 patent/US4708867A/en not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3775537A (en) * | 1970-06-27 | 1973-11-27 | Roehm Gmbh | Copolymer coatings for pharmaceuticals |
US3959540A (en) * | 1973-08-08 | 1976-05-25 | R.P. Scherer Gmbh | Gastric juice resistant gelatin capsules and a process for the production thereof |
US4101651A (en) * | 1975-09-29 | 1978-07-18 | Meiji Seika Kaisha, Ltd. | Process for preparing preparations for oral administration |
US4341759A (en) * | 1975-11-17 | 1982-07-27 | Aktiebolaget Hassle | Granule having controlled release properties |
US4150110A (en) * | 1976-05-14 | 1979-04-17 | Nippon Kayaku Kabushiki Kaisha | Coated granules of polyacrylic alkali metal salts and method of producing same |
Non-Patent Citations (2)
Title |
---|
Eudragit E Data Sheet (Info E 3/e), Eudragit E Application in the Production of Pharmaceutical Preparations. * |
Eudragit E Data Sheet (Info E-3/e), Eudragit E Application in the Production of Pharmaceutical Preparations. |
Cited By (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4971791A (en) * | 1985-08-26 | 1990-11-20 | The Procter & Gamble Company | Taste masking compositions |
WO1991001734A1 (en) * | 1989-07-26 | 1991-02-21 | Himedics, Inc. | Prednisone microencapsulated granules |
US6423340B1 (en) | 1989-11-22 | 2002-07-23 | Aktiebolaget Draco | Method for the treatment of inflammatory bowel diseases |
US5643602A (en) * | 1989-11-22 | 1997-07-01 | Astra Aktiebolag | Oral composition for the treatment of inflammatory bowel disease |
US5213811A (en) * | 1991-09-13 | 1993-05-25 | Sterling Drug Inc. | Oral sustained-release drug compositions |
US5328697A (en) * | 1992-02-10 | 1994-07-12 | Mallinckrodt Veterinary, Inc. | Compositions and processes for the sustained release of drugs |
US8357396B2 (en) | 1996-06-14 | 2013-01-22 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
US20030215500A1 (en) * | 1996-06-14 | 2003-11-20 | Motohiro Ohta | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
US8945618B2 (en) | 1996-06-14 | 2015-02-03 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
US8956650B2 (en) | 1996-06-14 | 2015-02-17 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
US6153220A (en) * | 1997-10-03 | 2000-11-28 | Elan Corporation, Plc | Taste-masked formulations |
US9040086B2 (en) | 2001-10-04 | 2015-05-26 | Aptalis Pharmatech, Inc. | Timed, sustained release systems for propranolol |
US9358214B2 (en) | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
EP1803448A3 (en) * | 2002-03-11 | 2007-09-12 | Novartis AG | Tasted masked veterinary solid compositions |
EP1803448A2 (en) * | 2002-03-11 | 2007-07-04 | Novartis AG | Tasted masked veterinary solid compositions |
US20050169971A1 (en) * | 2002-03-11 | 2005-08-04 | Hubert Thoma | Tasted masked veterinary solid compositions |
US8617587B2 (en) | 2002-03-11 | 2013-12-31 | Novartis Ag | Tasted masked veterinary solid compositions |
US20100074952A1 (en) * | 2002-03-11 | 2010-03-25 | Novartis Animal Health U.S., Inc. | Tasted masked veterinary solid compositions |
CN1652754B (en) * | 2002-03-11 | 2013-05-22 | 诺瓦提斯公司 | Tasted masked veterinary solid compositions |
WO2003075895A1 (en) * | 2002-03-11 | 2003-09-18 | Novartis Ag | Tasted masked veterinary solid compositions |
US20060039981A1 (en) * | 2002-09-04 | 2006-02-23 | Deepak Murpani | Taste masked dosage forms and processes for their preparation |
WO2004022037A1 (en) * | 2002-09-04 | 2004-03-18 | Ranbaxy Laboratories Limited | Taste masked dosage forms and processes for their preparation |
US8367111B2 (en) | 2002-12-31 | 2013-02-05 | Aptalis Pharmatech, Inc. | Extended release dosage forms of propranolol hydrochloride |
EP1759692A2 (en) * | 2003-03-10 | 2007-03-07 | Novartis AG | Taste-masked solid veterinary compositions |
EP1759692A3 (en) * | 2003-03-10 | 2007-09-12 | Novartis AG | Taste-masked solid veterinary compositions |
US20040191918A1 (en) * | 2003-03-28 | 2004-09-30 | Sandrine Isz | Evaluation of bitterness of active drugs |
US8747895B2 (en) | 2004-09-13 | 2014-06-10 | Aptalis Pharmatech, Inc. | Orally disintegrating tablets of atomoxetine |
US20060127479A1 (en) * | 2004-10-08 | 2006-06-15 | Natrajan Kumaraperumal | Solvent free taste masked pharmaceutical compositions |
US11452689B2 (en) | 2004-10-12 | 2022-09-27 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
US9884014B2 (en) | 2004-10-12 | 2018-02-06 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
US10130580B2 (en) | 2004-10-12 | 2018-11-20 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
US10568832B2 (en) | 2004-10-12 | 2020-02-25 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
US10471017B2 (en) | 2004-10-21 | 2019-11-12 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
US10952971B2 (en) | 2004-10-21 | 2021-03-23 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
US20060105039A1 (en) * | 2004-10-21 | 2006-05-18 | Jin-Wang Lai | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
US20060105038A1 (en) * | 2004-11-12 | 2006-05-18 | Eurand Pharmaceuticals Limited | Taste-masked pharmaceutical compositions prepared by coacervation |
US9161919B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
US9161918B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
US10045946B2 (en) | 2005-05-02 | 2018-08-14 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
US11147772B2 (en) | 2005-05-02 | 2021-10-19 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
US9566249B2 (en) | 2005-05-02 | 2017-02-14 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
US9579293B2 (en) | 2005-05-02 | 2017-02-28 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
US10500161B2 (en) | 2005-05-02 | 2019-12-10 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
WO2007126136A2 (en) * | 2006-04-27 | 2007-11-08 | Takeda Pharmaceutical Company Limited | Mask- tasting solid preparation of pioglitazone |
WO2007126136A3 (en) * | 2006-04-27 | 2008-10-30 | Takeda Pharmaceutical | Mask- tasting solid preparation of pioglitazone |
US8632808B2 (en) | 2006-04-27 | 2014-01-21 | Takeda Pharmaceutical Company Limited | Taste-masking solid preparation of pioglitazone |
US20100034891A1 (en) * | 2006-04-27 | 2010-02-11 | Takeda Pharmaceutical Company Limited | Taste-masking solid preparation of pioglitazone |
EP2398470A4 (en) * | 2009-02-23 | 2013-03-06 | Aptalis Pharmatech Inc | Controlled-release compositions comprising a proton pump inhibitor |
EP2398470A1 (en) * | 2009-02-23 | 2011-12-28 | Eurand, Inc. | Controlled-release compositions comprising a proton pump inhibitor |
US9233105B2 (en) | 2009-12-02 | 2016-01-12 | Adare Pharmaceuticals S.R.L. | Fexofenadine microcapsules and compositions containing them |
US10166220B2 (en) | 2009-12-02 | 2019-01-01 | Adare Pharmaceuticals S.R.L. | Fexofenadine microcapsules and compositions containing them |
US10729682B2 (en) | 2009-12-02 | 2020-08-04 | Adare Pharmaceuticals S.R.L. | Fexofenadine microcapsules and compositions containing them |
US8580313B2 (en) | 2009-12-02 | 2013-11-12 | Aptalis Pharma Limited | Fexofenadine microcapsules and compositions containing them |
US10111839B2 (en) | 2014-10-31 | 2018-10-30 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
US10507186B2 (en) | 2014-10-31 | 2019-12-17 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
US10512612B2 (en) | 2014-10-31 | 2019-12-24 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
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US10688060B2 (en) | 2014-10-31 | 2020-06-23 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
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US10292938B2 (en) | 2014-10-31 | 2019-05-21 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
US10292939B2 (en) | 2014-10-31 | 2019-05-21 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
US9974752B2 (en) | 2014-10-31 | 2018-05-22 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
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US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
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Legal Events
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Owner name: KEY PHARMACEUTICALS, INC. 18425 N.W. 2ND AVENUE MI Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:HSIAO, CHARLES H.;REEL/FRAME:004238/0539 Effective date: 19840301 |
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Effective date: 19991124 |
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Free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362 |