New! View global litigation for patent families

US4605564A - Coating process for making antimicrobial medical implant device - Google Patents

Coating process for making antimicrobial medical implant device Download PDF

Info

Publication number
US4605564A
US4605564A US06572744 US57274484A US4605564A US 4605564 A US4605564 A US 4605564A US 06572744 US06572744 US 06572744 US 57274484 A US57274484 A US 57274484A US 4605564 A US4605564 A US 4605564A
Authority
US
Grant status
Grant
Patent type
Prior art keywords
invention
xylenol
meta
catheter
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
US06572744
Inventor
James P. Kulla
Norman J. Huff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biological and Environmental Control Laboratories Inc
Original Assignee
Biological and Environmental Control Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/08Oxygen or sulfur directly attached to an aromatic ring system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/202Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with halogen atoms, e.g. triclosan, povidone-iodine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404Biocides, antimicrobial agents, antiseptic agents

Abstract

The invention relates to an antimicrobial medical implant device having a chlorinated phenol impregnated therein, such as para-chloro-meta-xylenol.

Description

BACKGROUND OF THE INVENTION

This invention relates in general to antimicrobial techniques and, in particular, to an antimicrobial medical implant device.

More specifically, but without restriction to the particular use which is shown and described, the invention relates to an antimicrobial medical implant device having a chlorinated phenol impregnated therein, such as parachloro-meta-xylenol.

The use of catheters in humans and animals is widespread in the treatment of countless diseases and conditions. The presence of catheters, however, generally involves the risk of bacterial and mycotic contamination and sepsis. An example of one type of catheter in which the problem of bacterial or other infection is prevalent is the well-known Foley catheter.

It has been found that patients, in whom a Foley catheter is implanted for more than several days, encounter a substantial risk of bladder infection. When catherized, such patients undergo a steady urine drip. As the urine is collected in the conventional manner, bacteria travel along the channel of the catheter back into the patient. The possibility of migration of bacteria and the like along the exterior route of the catheter is also possible. In the past, catheters have been coated with various antimicrobial substances, but such known techniques are generally ineffective over extended periods of time.

SUMMARY OF THE INVENTION

It is an object of this invention to provide an improved antimicrobial material.

Another object of this invention is to provide an antimicrobial medical implant device.

A further object of the invention is to impregnate a catheter or other implant with antimicrobial chlorinated phenols.

Still another object of this invention is to impregnate a catheter or other implant with a chlorinated phenol from 0.1% to 10% (wt/wt).

A still further object of this invention is to provide an improved method of impregnating a medical grade polymer with an antimicrobial agent.

These and other objects are attained in accordance with the present invention wherein there is provided an improved antimicrobial medical implant device such as a catheter intended for use in humans and incorporating a means for preventing infection. The catheter is impregnated with a chlorinated phenol, such as a para-chloro-meta-xylenol sold under the trademark Ottasept®. The impregnated catheter or implant of the invention is capable of extended antimicrobial activity and is relatively non-toxic. The antimicrobial implant of the invention is capable of superior prevention of the risk of contamination arising by virtue of a catheter or similar implant polymer within a human patient. Para-chloro-meta-xylenol is only slightly soluble in water (1 part in 3,000 parts) and aqueous body fluids. Thus, the ingredient remains active in the treatment and prevents infection for a greater period of time than other more soluble infection fighting compounds. These beneficial properties, which heretofore have not been taken advantage of in the prior art, are incorporated in the polymer of the implant device to accomplish the improved results of the invention.

DESCRIPTION OF THE INVENTION

This invention comprises the impregnating of a chlorinated phenol from 0.1% to 10% (wt/wt) into a latex, polymer, or other material intended for use in humans as a means of preventing infection. The invention of the application reduces or eliminates the risk of contamination in the presence of a medical implant and particularly is effective in connection with a well-known latex Foley catheter. The technique of impregnation herein disclosed is also advantageous in connection with other devices including, but not limited to, peritoneal-dialysis catheters (silicone or other polymers), intravenous catheters (polyurethane), ventricular shunts, arterio-venous shunts, fistula sets and other implants of latex or polymers. In addition, accessories attached to catheters and implants can likewise be impregnated with chlorinated phenols to further reduce infection risk, e.g. urine drain bags.

Although other chlorinated phenols may be used in accordance with the invention, it is found that para-chloro-meta-xylenol sold under the trademark Ottasept is highly effective. Para-chloro-meta-xylenol is particularly suitable, because of its low solubility and can be effectively impregnated into a latex or polymer. Para-chloro-meta-xylenol further has very broad bactericidal-fungicidal properties in low concentrations through a wide range of pH. Thus, para-chloro-meta-xylenol acts as an active ingredient while impregnated in latex or a polymer for extended periods of time in comparison to more soluble compounds known for use in treating or preventing infections. In addition, the compound has a long history of safe applications, is stable at room temperature, and is not readily absorbed by proteins.

Para-chloro-meta-xylenol has several synonyms including 3,5-dimethyl-4-chlorophenol, 2-chloro-m-5-xylenol, and 2,6-dimethyl-4-hydroxchlorobenzene. Para-chloro-meta-xylenol is impregnated into the latex (or other polymers) of a device by using an appropriate solvent, such as a chlorinated solvent. Other materials may require an alcohol solvent. A latex Foley catheter containing para-chloro-meta-xylenol (at 0.1%-10%) would reduce or eliminate the risk of contamination via the routes of insertion, along the outside of the catheter (catheter/urethral interface) or through the lumen of a catheter.

To impregnate a latex Foley catheter, the implant is immersed in a solution of 1%-6% para-chloro-meta-xylenol in dichloromethane. The dichloromethane causes considerable swelling of the latex. After immersion of the latex for approximately ninety minutes, the catheter is removed from the solution and allowed to dry at room temperature, during which time the latex returns to its original size. After drying, the latex catheter is rinsed for approximately thirty seconds in ethanol (or other alcohol). The resulting catheter is thus impregnated with para-chloro-meta-xylenol.

The invention is directed in general to the treatment of any polymer or latex with an organic solvent, such as dichloromethane or chlorinated ethanes, in which the para-chloro-meta-xylenol is readily soluble and which will also cause swelling of the polymer of interest. The solvent should be readily removable by evaporation or by a series of solvent exchanges with one or more other solvents like alcohol (ethanol) or water, so that the microbial agent, para-chloro-meta-xylenol, is trapped or is precipitated into the polymer structure as the polymer returns to its original size.

In some applications, the antimicrobial agent could be impregnated into a latex, polymer, or a fabric material, e.g. dacron, which is then attached to a device into which a chlorinated phenol is not easily incorporated.

While the invention has been described with reference to the preferred embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof without departing from the scope of the invention.

In addition, many modifications may be made to adapt a particular situation or material to the teachings of the invention without departing from the essential scope thereof. Therefore, it is intended that the invention not be limited to the particular embodiments disclosed as the best mode contemplated for carrying out this invention, but that the invention will include all embodiments falling within the scope of the appended claims.

Claims (4)

What is claimed is:
1. A process for making an antimicrobial medical implant device comprising the steps of:
providing a medical implant device formed of a composition comprising a medical grade polymer or latex;
treating said polymer or latex with a solution of para-chloro-meta-xylenol having a very low solubility in water and aqueous body fluids, with the para-chloro-meta-xylenol dissolved in an organic solvent to cause swelling of the polymer or latex;
thereafter removing the solvent from the solution to trap or precipitate the para-chloro-meta-xylenol in the polymer or latex structure;
whereby the para-chloro-meta-xylenol is impregnated within the structure of the polymer or latex.
2. A process as described in claim 1, wherein the para-chloro-meta-xylenol is 0.1 percent to 10 percent by weight.
3. A process as described in claim 1, wherein said solvent is dichloromethane.
4. A process as described in claim 1, wherein said solvent is carbon tetrachloride.
US06572744 1984-01-23 1984-01-23 Coating process for making antimicrobial medical implant device Expired - Fee Related US4605564A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US06572744 US4605564A (en) 1984-01-23 1984-01-23 Coating process for making antimicrobial medical implant device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06572744 US4605564A (en) 1984-01-23 1984-01-23 Coating process for making antimicrobial medical implant device

Publications (1)

Publication Number Publication Date
US4605564A true US4605564A (en) 1986-08-12

Family

ID=24289173

Family Applications (1)

Application Number Title Priority Date Filing Date
US06572744 Expired - Fee Related US4605564A (en) 1984-01-23 1984-01-23 Coating process for making antimicrobial medical implant device

Country Status (1)

Country Link
US (1) US4605564A (en)

Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0252120A1 (en) * 1985-12-16 1988-01-13 Colorado Biomedical, Inc. Antimicrobial catheter and method
WO1989004682A1 (en) * 1987-11-23 1989-06-01 Colorado Biomedical Incorporated Antimicrobial device and method
US4945121A (en) * 1987-08-18 1990-07-31 Koh-I-Noor Radiograph, Inc. Thermosetting dyed latex colorant dispersions
EP0405284A2 (en) * 1989-06-29 1991-01-02 Hercules Incorporated Pharmaceutically impregnated catheters
US5004461A (en) * 1989-03-23 1991-04-02 Wilson Joseph E Methods for rendering plastics thromboresistant and product
EP0520160A1 (en) * 1991-06-28 1992-12-30 BOC HEALTH CARE, Inc. Process for antimicrobial treatment of polyurethane
DE4143239A1 (en) * 1991-12-31 1993-07-01 Joerg Dipl Chem Schierholz Pharmaceutical agents containing implantable device made of a polymeric material, as well as processes for their preparation
US5489286A (en) * 1992-07-28 1996-02-06 Cinberg; James Z. Antibiotic impregnated myringotomy ventilation tube
US5562922A (en) * 1993-03-18 1996-10-08 Cedars-Sinai Medical Center Drug incorporating and release polymeric coating for bioprosthesis
US5624704A (en) * 1995-04-24 1997-04-29 Baylor College Of Medicine Antimicrobial impregnated catheters and other medical implants and method for impregnating catheters and other medical implants with an antimicrobial agent
US5772640A (en) * 1996-01-05 1998-06-30 The Trustees Of Columbia University Of The City Of New York Triclosan-containing medical devices
US6146688A (en) * 1997-12-23 2000-11-14 Morgan; Harry C. Method of creating a biostatic agent using interpenetrating network polymers
US6162487A (en) * 1995-11-08 2000-12-19 Baylor College Of Medicine Method of coating medical devices with a combination of antiseptics and antiseptic coating therefor
US6224579B1 (en) 1999-03-31 2001-05-01 The Trustees Of Columbia University In The City Of New York Triclosan and silver compound containing medical devices
US20020122876A1 (en) * 2000-12-22 2002-09-05 Modak Shanta M. Antimicrobial medical devices
US20030032765A1 (en) * 2000-09-27 2003-02-13 Mcdonald William F. Antimicrobial polymer
US20030157193A1 (en) * 2002-02-05 2003-08-21 Mcdonald William F. Antimicrobial polymer
US20040033242A1 (en) * 2002-08-16 2004-02-19 Mcdonald William F. Two dimensional polymer that generates nitric oxide
US20040068294A1 (en) * 2002-10-04 2004-04-08 Howard Scalzo Braided antimicrobial suture
US20040106912A1 (en) * 2002-12-02 2004-06-03 Cecilia Rosinskaya Method and composition for producing catheters with antibacterial property
US20040215129A1 (en) * 1999-09-16 2004-10-28 Gambro Ab Method and cycler for the administration of a peritoneal dialysis fluid
US20040220614A1 (en) * 2002-10-04 2004-11-04 Howard Scalzo Packaged antimicrobial medical device and method of preparing same
US20050101993A1 (en) * 2002-10-04 2005-05-12 Howard Scalzo Antimicrobial packaged medical device and method of preparing same
US20060085064A1 (en) * 1993-04-26 2006-04-20 Medtronic, Inc. Medical devices for delivering a therapeutic agent and method of preparation
US20060091034A1 (en) * 2002-10-04 2006-05-04 Howard Scalzo Method of preparing an antimicrobial packaged medical device
US7087661B1 (en) 1998-09-23 2006-08-08 Cernofina, Llc Safe and effective biofilm inhibitory compounds and health-related uses thereof
US20060217515A1 (en) * 2005-03-22 2006-09-28 Biosafe Inc. Method of creating a sustained silicon-containing quaternary ammonium antimicrobial agent within a polymeric material
US7204940B2 (en) 2002-03-20 2007-04-17 Michigan Biotechnology Institute Conductive polymer-based material
US20070106294A1 (en) * 2002-12-12 2007-05-10 Orion Industries, Ltd. Anti-microbial electrosurgical electrode and method of manufacturing same
US20090081249A1 (en) * 2007-08-27 2009-03-26 Massachusetts Institute Of Technology Bi-Functional Polymer-Attached Inhibitors of Influenza Virus
US7513093B2 (en) 2002-10-04 2009-04-07 Ethicon, Inc. Method of preparing a packaged antimicrobial medical device
US20100136072A1 (en) * 2006-11-08 2010-06-03 Massachusetts Institute Of Technology Polymeric Coatings that Inactivate Viruses and Bacteria
US20100136143A1 (en) * 2007-04-03 2010-06-03 Shmuel Bukshpan New compositions and methods for cell killing
US8112973B2 (en) 2002-10-04 2012-02-14 Ethicon, Inc. Method of making a packaged antimicrobial suture
US8960422B2 (en) 2002-10-04 2015-02-24 Ethicon, Inc. Packaged antimicrobial medical device and method of preparing same
US9474524B2 (en) 2002-10-04 2016-10-25 Ethicon, Inc. Packaged antimicrobial medical device having improved shelf life and method of preparing same

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2880129A (en) * 1956-01-19 1959-03-31 Johnson & Johnson Imparting anti-microbial properties to formed articles
US3566874A (en) * 1968-08-13 1971-03-02 Nat Patent Dev Corp Catheter
US3604426A (en) * 1969-05-06 1971-09-14 Elliot Lab Inc Method of applying semisolid bacteriostatic pads to urinary catheters
US4081267A (en) * 1975-02-14 1978-03-28 Sumitomo Chemical Company, Limited Pyridyltriazinone herbicidal compositions
US4318907A (en) * 1978-04-04 1982-03-09 Westwood Pharmaceuticals, Inc. Method for treating acne vulgaris and compositions useful for that purpose
US4355028A (en) * 1978-04-04 1982-10-19 Westwood Pharmaceuticals, Inc. Composition for treating acne vulgaris
US4381380A (en) * 1980-11-03 1983-04-26 Leveen Harry H Thermoplastic polyurethane article treated with iodine for antibacterial use
US4500339A (en) * 1980-09-03 1985-02-19 Young Robert W Adherent controlled release microbiocides containing hydrolyzable silanes

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2880129A (en) * 1956-01-19 1959-03-31 Johnson & Johnson Imparting anti-microbial properties to formed articles
US3566874A (en) * 1968-08-13 1971-03-02 Nat Patent Dev Corp Catheter
US3604426A (en) * 1969-05-06 1971-09-14 Elliot Lab Inc Method of applying semisolid bacteriostatic pads to urinary catheters
US4081267A (en) * 1975-02-14 1978-03-28 Sumitomo Chemical Company, Limited Pyridyltriazinone herbicidal compositions
US4318907A (en) * 1978-04-04 1982-03-09 Westwood Pharmaceuticals, Inc. Method for treating acne vulgaris and compositions useful for that purpose
US4355028A (en) * 1978-04-04 1982-10-19 Westwood Pharmaceuticals, Inc. Composition for treating acne vulgaris
US4500339A (en) * 1980-09-03 1985-02-19 Young Robert W Adherent controlled release microbiocides containing hydrolyzable silanes
US4381380A (en) * 1980-11-03 1983-04-26 Leveen Harry H Thermoplastic polyurethane article treated with iodine for antibacterial use

Cited By (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4917686A (en) * 1985-12-16 1990-04-17 Colorado Biomedical, Inc. Antimicrobial device and method
EP0252120A4 (en) * 1985-12-16 1990-09-26 Denver Surgical Developments, Inc. Antimicrobial catheter and method
EP0252120A1 (en) * 1985-12-16 1988-01-13 Colorado Biomedical, Inc. Antimicrobial catheter and method
US4945121A (en) * 1987-08-18 1990-07-31 Koh-I-Noor Radiograph, Inc. Thermosetting dyed latex colorant dispersions
WO1989004682A1 (en) * 1987-11-23 1989-06-01 Colorado Biomedical Incorporated Antimicrobial device and method
US5004461A (en) * 1989-03-23 1991-04-02 Wilson Joseph E Methods for rendering plastics thromboresistant and product
EP0405284A2 (en) * 1989-06-29 1991-01-02 Hercules Incorporated Pharmaceutically impregnated catheters
EP0405284A3 (en) * 1989-06-29 1991-03-27 Hercules Incorporated Pharmaceutically impregnated catheters
EP0520160A1 (en) * 1991-06-28 1992-12-30 BOC HEALTH CARE, Inc. Process for antimicrobial treatment of polyurethane
DE4143239A1 (en) * 1991-12-31 1993-07-01 Joerg Dipl Chem Schierholz Pharmaceutical agents containing implantable device made of a polymeric material, as well as processes for their preparation
US5489286A (en) * 1992-07-28 1996-02-06 Cinberg; James Z. Antibiotic impregnated myringotomy ventilation tube
US5562922A (en) * 1993-03-18 1996-10-08 Cedars-Sinai Medical Center Drug incorporating and release polymeric coating for bioprosthesis
US7811317B2 (en) 1993-04-26 2010-10-12 Medtronic, Inc. Medical devices for delivering a therapeutic agent and method of preparation
US7419696B2 (en) 1993-04-26 2008-09-02 Medtronic, Inc. Medical devices for delivering a therapeutic agent and method of preparation
US20060085064A1 (en) * 1993-04-26 2006-04-20 Medtronic, Inc. Medical devices for delivering a therapeutic agent and method of preparation
US20080275544A1 (en) * 1993-04-26 2008-11-06 Medtronic, Inc. Medical devices for delivering a therapeutic agent and method of preparation
US5624704A (en) * 1995-04-24 1997-04-29 Baylor College Of Medicine Antimicrobial impregnated catheters and other medical implants and method for impregnating catheters and other medical implants with an antimicrobial agent
US6706024B2 (en) 1995-06-07 2004-03-16 The Trustees Of Columbia University In The City Of New York Triclosan-containing medical devices
US6162487A (en) * 1995-11-08 2000-12-19 Baylor College Of Medicine Method of coating medical devices with a combination of antiseptics and antiseptic coating therefor
US6872195B2 (en) 1996-01-05 2005-03-29 The Trustees Of Columbia University In The City Of New York Chlorhexidine-containing medical devices
US6626873B1 (en) 1996-01-05 2003-09-30 Trustees Of Columbia University Tricolosan-containing medical devices
US6083208A (en) * 1996-01-05 2000-07-04 The Trustees Of Columbia University Of The City Of New York Triclosan-containing medical devices
US5772640A (en) * 1996-01-05 1998-06-30 The Trustees Of Columbia University Of The City Of New York Triclosan-containing medical devices
US20040039349A1 (en) * 1996-01-05 2004-02-26 Shanta Modak Tricolosan-containing medical devices
US6106505A (en) * 1996-01-05 2000-08-22 The Trustees Of Columbia University Of The City Of New York Triclosan-containing medical devices
US6572926B1 (en) 1997-12-23 2003-06-03 Biosafe, Inc. Biostatic product using interpenetrating network polymers
US6146688A (en) * 1997-12-23 2000-11-14 Morgan; Harry C. Method of creating a biostatic agent using interpenetrating network polymers
US20070020309A1 (en) * 1998-09-23 2007-01-25 Alberte Randall S Safe and effective biofilm inhibitory compounds and health related uses thereof
US7087661B1 (en) 1998-09-23 2006-08-08 Cernofina, Llc Safe and effective biofilm inhibitory compounds and health-related uses thereof
US20050124725A1 (en) * 1999-03-31 2005-06-09 Shanta Modak Triclosan and silver compound containing medical devices
US6224579B1 (en) 1999-03-31 2001-05-01 The Trustees Of Columbia University In The City Of New York Triclosan and silver compound containing medical devices
US6843784B2 (en) 1999-03-31 2005-01-18 The Trustees Of Columbia University In The City Of New York Triclosan and silver compound containing medical devices
US20040215129A1 (en) * 1999-09-16 2004-10-28 Gambro Ab Method and cycler for the administration of a peritoneal dialysis fluid
US20030220467A9 (en) * 2000-09-27 2003-11-27 Mcdonald William F. Antimicrobial polymer
US6797743B2 (en) 2000-09-27 2004-09-28 Michigan Biotechnology Institute Antimicrobial polymer
US20030032765A1 (en) * 2000-09-27 2003-02-13 Mcdonald William F. Antimicrobial polymer
US7537779B2 (en) 2000-12-22 2009-05-26 The Trustees Of Columbia University In The City Of New York Antimicrobial medical devices
US7329412B2 (en) 2000-12-22 2008-02-12 The Trustees Of Columbia University In The City Of New York Antimicrobial medical devices containing chlorhexidine free base and salt
US8906401B2 (en) 2000-12-22 2014-12-09 The Trustees Of Columbia University In The City Of New York Antimicrobial medical devices containing chlorhexidine free base and salt
US8383143B2 (en) 2000-12-22 2013-02-26 The Trustees Of Columbia University In The City Of New York Antimicrobial medical devices containing chlorhexidine free base and salt
US20040052831A1 (en) * 2000-12-22 2004-03-18 Modak Shanta M. Antimicrobial medical devices
US20020122876A1 (en) * 2000-12-22 2002-09-05 Modak Shanta M. Antimicrobial medical devices
US6939554B2 (en) 2002-02-05 2005-09-06 Michigan Biotechnology Institute Antimicrobial polymer
US20030157193A1 (en) * 2002-02-05 2003-08-21 Mcdonald William F. Antimicrobial polymer
US7204940B2 (en) 2002-03-20 2007-04-17 Michigan Biotechnology Institute Conductive polymer-based material
US20040033242A1 (en) * 2002-08-16 2004-02-19 Mcdonald William F. Two dimensional polymer that generates nitric oxide
US6951902B2 (en) 2002-08-16 2005-10-04 Michigan Biotechnology Institute Two dimensional polymer that generates nitric oxide
US20090301033A1 (en) * 2002-10-04 2009-12-10 Ethicon, Inc. Method of preparing a packaged antimicrobial medical device
US8960422B2 (en) 2002-10-04 2015-02-24 Ethicon, Inc. Packaged antimicrobial medical device and method of preparing same
US9149273B2 (en) 2002-10-04 2015-10-06 Ethicon, Inc. Packaged antimicrobial medical device
US8668867B2 (en) 2002-10-04 2014-03-11 Ethicon, Inc. Method of preparing an antimicrobial packaged medical device
US9474524B2 (en) 2002-10-04 2016-10-25 Ethicon, Inc. Packaged antimicrobial medical device having improved shelf life and method of preparing same
US20060091034A1 (en) * 2002-10-04 2006-05-04 Howard Scalzo Method of preparing an antimicrobial packaged medical device
US20050101993A1 (en) * 2002-10-04 2005-05-12 Howard Scalzo Antimicrobial packaged medical device and method of preparing same
US20040220614A1 (en) * 2002-10-04 2004-11-04 Howard Scalzo Packaged antimicrobial medical device and method of preparing same
US9597067B2 (en) 2002-10-04 2017-03-21 Ethicon, Inc. Packaged antimicrobial medical device and method of preparing same
US8133437B2 (en) 2002-10-04 2012-03-13 Ethicon, Inc. Method of preparing an antimicrobial packaged medical device
US7513093B2 (en) 2002-10-04 2009-04-07 Ethicon, Inc. Method of preparing a packaged antimicrobial medical device
US20040068294A1 (en) * 2002-10-04 2004-04-08 Howard Scalzo Braided antimicrobial suture
US8112973B2 (en) 2002-10-04 2012-02-14 Ethicon, Inc. Method of making a packaged antimicrobial suture
US8156718B2 (en) 2002-10-04 2012-04-17 Ethicon, Inc. Method of preparing a packaged antimicrobial medical device
US20040068293A1 (en) * 2002-10-04 2004-04-08 Howard Scalzo Packaged antimicrobial medical device and method of preparing same
US9597072B2 (en) 2002-10-04 2017-03-21 Ethicon, Inc. Method of preparing a packaged antimicrobial medical device
US7597903B2 (en) * 2002-12-02 2009-10-06 Shenkar College Of Engineering And Design Method and composition for producing catheters with antibacterial property
US20040106912A1 (en) * 2002-12-02 2004-06-03 Cecilia Rosinskaya Method and composition for producing catheters with antibacterial property
US7718212B2 (en) 2002-12-12 2010-05-18 Innovatech, Llc Anti-microbial electrosurgical electrode and method of manufacturing same
US20070106294A1 (en) * 2002-12-12 2007-05-10 Orion Industries, Ltd. Anti-microbial electrosurgical electrode and method of manufacturing same
US20070123853A1 (en) * 2002-12-12 2007-05-31 Orion Industries, Ltd. Anti-microbial electrosurgical electrode and method of manufacturing same
US7955637B2 (en) * 2002-12-12 2011-06-07 Innovatech Llc Anti-microbial electrosurgical electrode and method of manufacturing same
US7288091B2 (en) 2002-12-12 2007-10-30 Orion Industries, Ltd. Anti-microbial electrosurgical electrode and method of manufacturing same
US20100215834A1 (en) * 2002-12-12 2010-08-26 Innovatech, Llc Anti-microbial electrosurgical electrode and method of manufacturing same
US7390326B2 (en) 2002-12-12 2008-06-24 Orion, Industries, Ltd. Anti-microbial electrosurgical electrode and method of manufacturing same
US20080050509A1 (en) * 2002-12-12 2008-02-28 Orion Industries, Ltd. Anti-microbial electrosurgical electrode and method of manufacturing same
US20060217515A1 (en) * 2005-03-22 2006-09-28 Biosafe Inc. Method of creating a sustained silicon-containing quaternary ammonium antimicrobial agent within a polymeric material
US7858141B2 (en) 2005-03-22 2010-12-28 Biosafe Inc. Method of creating a sustained silicon-containing quaternary ammonium antimicrobial agent within a polymeric material
US7851653B2 (en) 2005-03-22 2010-12-14 Biosafe, Inc. Method of creating a solvent-free polymeric silicon-containing quaternary ammonium antimicrobial agent having superior sustained antimicrobial properties
US20060223962A1 (en) * 2005-03-22 2006-10-05 Biosafe Inc. Method of creating a solvent-free polymeric silicon-containing quaternary ammonium antimicrobial agent having superior sustained antimicrobial properties
US20100136072A1 (en) * 2006-11-08 2010-06-03 Massachusetts Institute Of Technology Polymeric Coatings that Inactivate Viruses and Bacteria
US20100136143A1 (en) * 2007-04-03 2010-06-03 Shmuel Bukshpan New compositions and methods for cell killing
US20090081249A1 (en) * 2007-08-27 2009-03-26 Massachusetts Institute Of Technology Bi-Functional Polymer-Attached Inhibitors of Influenza Virus

Similar Documents

Publication Publication Date Title
US4999210A (en) Anti-infective and antithrombogenic medical articles and method for their preparation
US5834051A (en) Intramuscular stimulation lead with enhanced infection resistance
US6228354B1 (en) Water resistant film-forming antimicrobial skin-preparation
US5041100A (en) Catheter and hydrophilic, friction-reducing coating thereon
US4911691A (en) Assembly for adminstering IV solution
US5071648A (en) Polymeric broad-spectrum antimicrobial materials
US5165952A (en) Anti-infective and antithrombogenic medical articles and method for their preparation
US5019096A (en) Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same
US6273875B1 (en) Medical devices having improved antimicrobial/antithrombogenic properties
US4381380A (en) Thermoplastic polyurethane article treated with iodine for antibacterial use
US4364929A (en) Germicidal colloidal lubricating gels and method of producing the same
US6309660B1 (en) Universal biocompatible coating platform for medical devices
US6183764B1 (en) Microbicide treated polymeric materials
Sherertz et al. Efficacy of dicloxacillin-coated polyurethane catheters in preventing subcutaneous Staphylococcus aureus infection in mice.
Schierholz et al. Efficacy of silver-coated medical devices
US4950256A (en) Non-thrombogenic intravascular time release catheter
US5616119A (en) Medicated polymeric apparatus
US6921390B2 (en) Long-term indwelling medical devices containing slow-releasing antimicrobial agents and having a surfactant surface
US3896814A (en) Collagen based threads
Lansdown Silver in health care: antimicrobial effects and safety in use
US5328954A (en) Encrusting and bacterial resistant coatings for medical applications
US6416546B1 (en) Medical device and production method thereof
US20050124970A1 (en) Luer cap with antibacterial property
US20030091641A1 (en) Antimicrobial polymeric surfaces
US5470585A (en) Medicinal substance for topical application

Legal Events

Date Code Title Description
AS Assignment

Owner name: BIOLOGICAL & ENVIRONMENTAL CONTROL LABORATORIES, I

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNORS:KULLA, JAMES P.;HUFF, NORMAN J.;REEL/FRAME:004221/0487

Effective date: 19840110

FPAY Fee payment

Year of fee payment: 4

REMI Maintenance fee reminder mailed
LAPS Lapse for failure to pay maintenance fees
FP Expired due to failure to pay maintenance fee

Effective date: 19940817