US4266557A - Low friction syringe - Google Patents

Low friction syringe Download PDF

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Publication number
US4266557A
US4266557A US06053492 US5349279A US4266557A US 4266557 A US4266557 A US 4266557A US 06053492 US06053492 US 06053492 US 5349279 A US5349279 A US 5349279A US 4266557 A US4266557 A US 4266557A
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US
Grant status
Grant
Patent type
Prior art keywords
barrel
plug
chamber
flange
plunger
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US06053492
Inventor
Jack D. Merry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kendall Co
Original Assignee
Kendall Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31513Piston constructions to improve sealing or sliding
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150015Source of blood
    • A61B5/15003Source of blood for venous or arterial blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150236Pistons, i.e. cylindrical bodies that sit inside the syringe barrel, typically with an air tight seal, and slide in the barrel to create a vacuum or to expel blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150244Rods for actuating or driving the piston, i.e. the cylindrical body that sits inside the syringe barrel, typically with an air tight seal, and slides in the barrel to create a vacuum or to expel blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150732Needle holders, for instance for holding the needle by the hub, used for example with double-ended needle and pre-evacuated tube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/153Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31521Pistons with a forward extending skirt at their front end

Abstract

A low friction syringe comprising, a barrel defining a chamber, a plunger having a distal end received in the barrel chamber, and a plug of elastic material having a body portion secured to the distal end of the plunger. The plug has first and second annular flanges respectively extending forwardly and rearwardly from the body portion. The first and second flanges have an enlarged outer annular lip lightly contacting an inner surface of the barrel, and an annular hinge portion adjacent the body portion to permit flexation of the flanges responsive to differential pressures between a cavity intermediate the flanges and either the chamber or the atmosphere. The flanges also permit free movement of the plug in the chamber under relatively low friction between the plug and the syringe barrel.

Description

This is a continuation of application Ser. No. 869,729 filed Jan. 16, 1978, now abandoned.

BACKGROUND OF THE INVENTION

The present invention relates to syringes, and more particularly to syringes which are useful for certain medical procedures.

In recent years, gas analysis of arterial blood has become one of the most important laboratory tests in the management of patients with respiratory and metabolic disorders. However, the collection of a satisfactory arterial blood sample from a patient for analysis has posed a number of difficulties. Initially, in some patients it may be somewhat difficult to ascertain whether the collection device has received arterial or venous blood without measuring for the relatively high arterial pressures during collection. Second, the collection device should minimize contact of the blood sample with air since the air may affect the results of gas analysis. It is also desirable that the sample should not be collected in the presence of a vacuum, since it is believed that the vacuum may modify the gas characteristics of the sample. Finally, the device must prevent coagulation of the blood sample, and should be in a suitable form to permit closure of the sample to air and chilling during the period of time between collection and analysis.

In the past, plastic and ground glass syringes with a needle have been commonly used to collect the samples. However, prior syringes with rubber plugs of conventional design have proven deficient for such purposes due to the relatively high resistance between the syringe plunger and barrel. The plunger resistance in conventional plastic syringes prevents movement of the plunger responsive to arterial pressure alone, and requires that the plunger be manually withdrawn, thus creating an undesirable vacuum in the syringe chamber during collection. Further, since the plungers of such plastic syringes are not sufficiently mobile to move under arterial pressure, they do not provide an indication whether arterial or venous blood is being collected. Although the plungers of the ground glass syringes may be used to detect arterial pressure, the ground glass syringes are excessively expensive relative the plastic syringes.

During other medical procedures, such as an epidural anesthesia procedure, it is necessary to position the tip of a needle at a relatively precise position inside the patient's body. During this particular procedure, the needle tip should be located in the potential epidural space where the body pressure during insertion of the needle is normally slightly negative. If the needle tip has been advanced too far into the body, it projects through the dura mater into the subarachnoid space where the body pressure is positive. A ground glass syringe may be utilized in this procedure to determine the location of the needle tip through use of the relative body pressures, but conventional plastic syringes have not been sufficiently responsive to pressures for this purpose. Since syringes are normally considered a disposable item, it is desirable to reduce their cost to the hospital and patient below that of the relatively expensive ground glass syringes.

SUMMARY OF THE INVENTION

A principal feature of the present invention is the provision of an improved syringe of simplified construction and reduced cost.

The syringe of the present invention comprises, a barrel having an inner surface defining a chamber, a plunger having a distal end received in the barrel chamber, and a plug of elastic material received in the chamber and having a body portion secured to the distal end of the plunger. The plug has a first annular flange extending forwardly from the body portion, with the first flange having an enlarged outer annular lip lightly contacting the inner surface of the barrel, and an annular hinge portion adjacent the body portion of reduced thickness relative the thickness of the lip. The plug has a second annular flange extending rearwardly from the body portion, with the second flange having an enlarged outer annular lip lightly contacting the inner surface of the barrel, and an annular hinge portion adjacent the body portion of reduced thickness relative the thickness of the second flange lip, with the first and second flanges defining an annular cavity intermediate the body portion and the barrel.

A feature of the present invention is that the plug flanges have minimal resistance for the syringe barrel to permit relatively free movement of the plug and plunger in the barrel.

Another feature of the invention is that the first flange flexes against the inner surface of the barrel responsive to a slightly greater pressure in the chamber relative the cavity during forward movement of the plunger in the barrel.

Thus, a feature of the invention is that a seal is accomplished in the syringe while pumping fluid out of the chamber.

Yet another feature of the invention is that the first flange flexes about its hinge away from the inner surface of the barrel responsive to a slightly less pressure in the chamber relative the cavity, and the second flange flexes against the inner surface of the barrel responsive to a slightly less pressure in the communicating chamber and cavity relative atmospheric pressure during rearward movement of the plunger in the barrel.

Accordingly, still another feature of the invention is that a seal is accomplished through cooperation of the first and second flanges during aspiration by the syringe.

A further feature of the invention is that the syringe may be constructed at a reduced cost while providing minimal friction of plunger movement normally accomplished by relatively expensive precision ground glass syringes.

Further features will become more fully apparent in the following description of the embodiments of this invention and from the appended claims.

DESCRIPTION OF THE DRAWINGS

In the drawings:

FIG. 1 is an elevational view, partly broken away, of a low friction syringe of the present invention;

FIG. 2 is a fragmentary sectional view of the syringe of FIG. 1;

FIG. 3 is a fragmentary sectional view illustrating use of the syringe during forward movement of a syringe plunger and plug in a chamber of the syringe;

FIG. 4 is a fragmentary sectional view illustrating use of the syringe during rearward movement of the syringe plunger and plug in the chamber; and

FIG. 5 is an elevational view, taken partly in section, of another embodiment of the syringe of the present invention.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

Referring now to FIGS. 1 and 2, there is shown a syringe generally designated 10 having a barrel 12, an elongated plunger 14, and a plug 16 of elastic material secured to a distal end 18 of the plunger 14. The syringe barrel 12 has an inner surface 20 defining a chamber 22, a tip 24 at a distal end 26 of the barrel, and a conventional leur lock 28 for securement of the syringe barrel to a suitable instrument, such as a needle (not shown).

With reference to FIG. 2, the plug 16 is slidably received in the barrel chamber 22, and has a main body portion 34 defining a recess 30 which receives a boss 32 projecting forwardly from the distal end 18 of the plunger 14 in order to secure the plug 16 onto the distal end 18 of the plunger. The plug 16 has a first annular flange 36 extending forwardly or distally from the body portion 34 in the syringe chamber, with the first flange 36 having an enlarged outer annular lip 38 which lightly contacts the inner surface 20 of the syringe barrel 12, and an annular hinge portion 40 adjacent the body portion 34 and having a reduced thickness relative the thickness of the lip 38. The plug 16 also has a second annular flange 42 extending rearwardly or proximally from the body portion 34, with the second flange 42 having an enlarged outer annular lip 44 lightly contacting the inner surface 20 of the syringe barrel 12, and an annular hinge portion 46 of reduced thickness relative the thickness of the second flange lip 44. As shown, the first and second flanges 36 and 42 define an annular cavity 48 intermediate the body portion 34 and the inner surface 20 of the barrel 12.

The hinge portions 40 and 46 of the first and second flanges 36 and 42, respectively, permit ready flexation of the flanges relative the barrel 12, and under normal conditions cause slight contact of the respective flange lips 38 and 44 against the syringe barrel 12. As a result, the syringe plug has relatively low friction against movement in the barrel surface 20, permitting free movement of the plunger and plug in the syringe barrel. Thus, the syringe of the present invention may be utilized in special medical procedures, such as collecting arterial blood or an epidural anesthesia procedure, where free movement of the syringe plunger in the barrel is required, previously accomplished by precision ground glass syringes. The syringe barrel 12 and plunger 14 may be made from relatively inexpensive plastic materials, such as polypropylene, while the syringe plug 16 may be constructed from inexpensive elastomers, such as polyisoprene rubber. Thus, the syringe of the present invention may be constructed in a simplified manner from inexpensive parts, while accomplishing results of relatively expensive ground glass syringes.

In addition to accomplishing this objective, the syringe plug 16 provides an effective seal for pumping and aspirating fluids. With reference to FIG. 3, during forward pumping movement of the syringe plunger 14 in the barrel 12, the pressure in the syringe chamber 22 increases to an amount slightly greater than the pressure in the cavity 48, causing a differential pressure between the chamber 22 and cavity 48 and flexation of the first flange 36 into increased engagement against the inner surface 20 of the syringe barrel 12. As a result, the first flange 36 provides an effective seal for the plug 16 during pumping of fluids from the syringe chamber.

With reference to FIG. 4, when the syringe plunger is withdrawn slightly in a rearward direction in the chamber 22, during aspiration of fluids, the pressure in the chamber 22 decreases to an amount slightly less than the pressure in the cavity 48, causing inward flexation of the first flange 36 and lip 38 away from the inner surface 20 of the barrel 12 in order to establish communication between the chamber 22 and cavity 48. In this configuration, the pressures in both the communicating chamber 22 and cavity 48 become less than atmospheric pressure outside the plug 16, and the second flange 42 thus flexes against the inner surface 20 of the syringe barrel 12 into increased engagement to accomplish an effective seal during withdrawal of the syringe plunger 14. In this manner, the plug 16 permits aspiration of fluids into the syringe chamber 22.

Thus, in accordance with the present invention, the syringe provides relatively free movement of the plunger and plug along the syringe barrel under conditions of relatively low friction between the plug and barrel in order to permit use of the syringe in special medical procedures, as previously described. Further, the syringe of the invention permits pumping and aspiration of fluids through flexation and cooperation of the plug flanges.

Another embodiment of the present invention is illustrated in FIG. 5, in which like reference numerals designate like parts. In this embodiment, the syringe barrel 12 has an enlarged section 50 at a proximal end of the barrel which has an internal diameter greater than the outer diameter of the plug 16 including the flanges 36 and 42. The plug 16 may be positioned in the section 50 for extended storage prior to use in order to minimize contact of the plug 16 against the syringe barrel 12, and thus minimize the possibility that the plug flanges may otherwise assume a set due to prolonged contact against the syringe barrel.

The foregoing detailed description is given for clearness of understanding only, and no unnecessary limitations should be understood therefrom, as modifications will be obvious to those skilled in the art.

Claims (3)

I claim:
1. A low friction syringe, comprising:
a barrel having an inner surface defining a chamber;
a plunger having a distal end received in the barrel chamber; and
a plug of elastic material received in said chamber and having a body portion secured to said distal end of the plunger, said plug having a first annular flange extending forwardly from said body portion, said first flange having an enlarged outer annular lip lightly contacting the inner surface of said barrel, and an annular hinge portion adjacent said body portion of reduced thickness relative the thickness of said lip, said plug having a second annular flange extending rerwardly from the body portion, said second flange having an enlarged outer annular lip lightly contacting the inner surface of said barrel, and an annular hinge portion adjacent said body portion of reduced thickness relative the thickness of the second flange lip, said first and second flanges defining an annular cavity intermediate the body portion and the barrel, said first flange flexing against the inner surface of the barrel responsive to a slightly greater pressure in the chamber relative the cavity during forward movement of the plunger in the barrel, and said first flange flexing about its hinge away from the inner surface of the barrel responsive to a slightly less pressure in the chamber relative the cavity and said second flange flexing against the inner surface of the barrel responsive to a slightly less pressure in the communicating chamber and cavity relative the pressure rearward the plug during rearward movement of the plunger in the barrel, said plug having a width between inner ends of said hinge portions of the first and second flanges substantially greater than the thickness of the first and second flanges, such that said plug flexes substantially only in said flange portions and the second flange contacts the barrel during said forward and rearward movements of the plunger in the barrel.
2. The syringe of claim 1 wherein said barrel and plunger are constructed from a plastic material.
3. The syringe of claim 1 wherein said barrel includes an enlarged section adjacent a rearward end of the barrel having an internal diameter slightly larger than the outer diameter of the first and second flanges.
US06053492 1978-01-16 1979-06-29 Low friction syringe Expired - Lifetime US4266557A (en)

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US86972978 true 1978-01-16 1978-01-16
US06053492 US4266557A (en) 1978-01-16 1979-06-29 Low friction syringe

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US06053492 US4266557A (en) 1978-01-16 1979-06-29 Low friction syringe

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Cited By (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982004387A1 (en) * 1981-06-01 1982-12-23 David H Malcolm Hemoseal blood collection device
US4405249A (en) * 1980-03-28 1983-09-20 National Research Development Corporation Dispensing apparatus and method
US4448206A (en) * 1981-08-17 1984-05-15 Martell Michael D Vented, aspirating syringe
WO1987001929A1 (en) * 1985-10-07 1987-04-09 Muehlbauer Ernst Application syringe for a dental substance and process for making these
US4690154A (en) * 1985-06-03 1987-09-01 Timothy Woodford Vented syringe
US4774963A (en) * 1981-05-20 1988-10-04 Terumo Kabushiki Kaisha Blood collector
EP0302248A1 (en) * 1987-07-21 1989-02-08 WASSERBURGER ARZNEIMITTELWERK DR. MADAUS GMBH & CO. KG Injection syringe for medical purposes
US4852768A (en) * 1987-03-25 1989-08-01 Blendax-Werke R. Schneider Gmbh & Co. Dosing syringe
US5070885A (en) * 1990-06-11 1991-12-10 Care Medical Devices, Inc. Disposable blood collection device
EP0539348A1 (en) * 1991-10-22 1993-04-28 Erwin Wimmer Single-use syringe
US5236420A (en) * 1992-06-01 1993-08-17 Pfleger Frederick W Bypass, pressurizing piston for chambers
US5314416A (en) * 1992-06-22 1994-05-24 Sherwood Medical Company Low friction syring assembly
US5356393A (en) * 1990-05-10 1994-10-18 Habley Medical Technology Corporation Plural diameter syringe
US5397313A (en) * 1994-01-27 1995-03-14 The Kendall Company Low friction syringe
US5496285A (en) * 1993-11-19 1996-03-05 Firma Carl Freudenberg Disposable syringe
US5549573A (en) * 1992-05-21 1996-08-27 Wask+E,Uml O+Ee Nig; Wilhelm Syringe
US5620423A (en) * 1993-09-23 1997-04-15 Heraeus Kulzer Gmbh Syringe for the controlled discharge of viscous materials
US5735825A (en) * 1996-03-22 1998-04-07 Merit Medical Systems, Inc. Syringe plunger tip
US6544233B1 (en) * 1999-10-18 2003-04-08 Terumo Kabushiki Kaisha Pre-filled syringe
US20040138611A1 (en) * 2000-10-10 2004-07-15 Meridian Medical Technologies, Inc. Wet/dry automatic injector assembly
US20040254543A1 (en) * 2000-10-10 2004-12-16 Griffiths Steven M. Needle and hub assembly for automatic injector
US20050187532A1 (en) * 2004-02-24 2005-08-25 Medex, Inc. Diaphragm-based reservoir for a closed blood sampling system
US20070287965A1 (en) * 2006-06-13 2007-12-13 Nordson Corporation Liquid dispensing syringe
US20080188823A1 (en) * 2005-01-12 2008-08-07 Biogen Idec Ma Inc Method for Delivering Interferon-Beta
US20080287885A1 (en) * 2005-11-14 2008-11-20 Hans-Rainer Hoffmann Cylinder/Piston Unit Having a Non-Cylindrical Chamber
CN100435871C (en) 2005-09-09 2008-11-26 余利荣 Injection with low resistance
US20080300550A1 (en) * 2007-06-04 2008-12-04 Becton, Dickinson And Company Positive displacement stopper for a pre-filled syringe
US20090047622A1 (en) * 2007-07-20 2009-02-19 Voco Gmbh Syringe and Method for Dosed Dispensing of Materials
WO2010006499A1 (en) * 2008-07-14 2010-01-21 Luo Xingyu Sealed self-destructive one-off injector
US20110034882A1 (en) * 2007-06-04 2011-02-10 Becton, Dickinson And Company Stoppers Used in Pre-filled Syringes
KR20110110110A (en) * 2008-11-26 2011-10-06 어시스트 메디칼 시스템즈, 인크. Apparatus and methods for fluid pressurizing units of injection systems
CN103533977A (en) * 2011-03-28 2014-01-22 贝克顿·迪金森公司 Plastic stopper
USD750228S1 (en) 2007-06-12 2016-02-23 Nordson Corporation Piston for a liquid dispensing syringe
US20160243311A1 (en) * 2013-10-09 2016-08-25 Aptar Stelmi Sas Sliding plunger-plug and syringe device comprising such a plunger-plug
WO2016153912A1 (en) * 2015-03-24 2016-09-29 Bd Technologies Time-of-use activated syringe stopper
WO2017025253A1 (en) * 2015-08-13 2017-02-16 Carebay Europe Ltd A stopper for a medicament container
US9827376B2 (en) 2014-01-29 2017-11-28 Becton, Dickinson And Company Plunger assembly including a plunger rod for advancing a stopper through a syringe
US9999731B2 (en) 2015-06-16 2018-06-19 ZebraSci, Inc Self-lubricating medical syringes

Citations (4)

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FR1333235A (en) * 1962-06-16 1963-07-26 Piston joined in a single piece molded plastic syringe for use once
FR1500009A (en) * 1966-05-27 1967-11-03 Sodip Sa Development syringes
DE2025379A1 (en) * 1968-11-27 1971-12-09
DE2514412A1 (en) * 1975-04-02 1976-10-14 Wimmer Pharma Gummi Gmbh Separating piston for two chamber ampoule type injection syringe - with cup-type seal permitting transfer of injection liquid but sealing on injection

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1333235A (en) * 1962-06-16 1963-07-26 Piston joined in a single piece molded plastic syringe for use once
FR1500009A (en) * 1966-05-27 1967-11-03 Sodip Sa Development syringes
DE2025379A1 (en) * 1968-11-27 1971-12-09
DE2514412A1 (en) * 1975-04-02 1976-10-14 Wimmer Pharma Gummi Gmbh Separating piston for two chamber ampoule type injection syringe - with cup-type seal permitting transfer of injection liquid but sealing on injection

Cited By (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4405249A (en) * 1980-03-28 1983-09-20 National Research Development Corporation Dispensing apparatus and method
US4774963A (en) * 1981-05-20 1988-10-04 Terumo Kabushiki Kaisha Blood collector
WO1982004387A1 (en) * 1981-06-01 1982-12-23 David H Malcolm Hemoseal blood collection device
US4448206A (en) * 1981-08-17 1984-05-15 Martell Michael D Vented, aspirating syringe
US4690154A (en) * 1985-06-03 1987-09-01 Timothy Woodford Vented syringe
EP0220551A1 (en) * 1985-10-07 1987-05-06 Ernst Mühlbauer Dental mass application syringe and its production method
US4798596A (en) * 1985-10-07 1989-01-17 Muehlbauer Ernst Applicator syringe for a dental compound
WO1987001929A1 (en) * 1985-10-07 1987-04-09 Muehlbauer Ernst Application syringe for a dental substance and process for making these
US4904437A (en) * 1985-10-07 1990-02-27 Muehlbauer Ernst Method for producing a syringe body for a dental compound
US4852768A (en) * 1987-03-25 1989-08-01 Blendax-Werke R. Schneider Gmbh & Co. Dosing syringe
EP0302248A1 (en) * 1987-07-21 1989-02-08 WASSERBURGER ARZNEIMITTELWERK DR. MADAUS GMBH & CO. KG Injection syringe for medical purposes
US5356393A (en) * 1990-05-10 1994-10-18 Habley Medical Technology Corporation Plural diameter syringe
US5070885A (en) * 1990-06-11 1991-12-10 Care Medical Devices, Inc. Disposable blood collection device
USRE35539E (en) * 1990-06-11 1997-06-24 Care Medical Devices, Inc. Disposable blood collection device
EP0539348A1 (en) * 1991-10-22 1993-04-28 Erwin Wimmer Single-use syringe
US5549573A (en) * 1992-05-21 1996-08-27 Wask+E,Uml O+Ee Nig; Wilhelm Syringe
US5236420A (en) * 1992-06-01 1993-08-17 Pfleger Frederick W Bypass, pressurizing piston for chambers
WO1993024156A1 (en) * 1992-06-01 1993-12-09 Pfleger Frederick W Bypass, pressurizing piston for chambers
US5314416A (en) * 1992-06-22 1994-05-24 Sherwood Medical Company Low friction syring assembly
US5620423A (en) * 1993-09-23 1997-04-15 Heraeus Kulzer Gmbh Syringe for the controlled discharge of viscous materials
US5496285A (en) * 1993-11-19 1996-03-05 Firma Carl Freudenberg Disposable syringe
US5397313A (en) * 1994-01-27 1995-03-14 The Kendall Company Low friction syringe
US5735825A (en) * 1996-03-22 1998-04-07 Merit Medical Systems, Inc. Syringe plunger tip
US6544233B1 (en) * 1999-10-18 2003-04-08 Terumo Kabushiki Kaisha Pre-filled syringe
US20090205744A1 (en) * 2000-10-10 2009-08-20 Meridian Medical Technologies, Inc. Methods of forming a needle and hub assembly for automatic injectors
US20040254543A1 (en) * 2000-10-10 2004-12-16 Griffiths Steven M. Needle and hub assembly for automatic injector
US8568367B2 (en) 2000-10-10 2013-10-29 Meridian Medical Technologies, Inc. Needle assemblies for wet/dry automatic injectors
US20070123818A1 (en) * 2000-10-10 2007-05-31 Meridian Medical Technologies, Inc. Needle assemblies for wet/dry automatic injectors
US7608055B2 (en) 2000-10-10 2009-10-27 Meridian Medical Technologies, Inc. Flow-path inserts for wet/dry automatic injectors
US8506526B2 (en) 2000-10-10 2013-08-13 Meridian Medical Technologies, Inc. Seal structures for wet/dry automatic injectors
US20100228190A1 (en) * 2000-10-10 2010-09-09 Meridian Medical Technologies, Inc. Seal structures for wet/dry automatic injectors
US7757370B2 (en) 2000-10-10 2010-07-20 Meridian Medical Technologies, Inc. Methods of forming a needle and hub assembly for automatic injectors
US7749190B2 (en) 2000-10-10 2010-07-06 Meridan Medical Technologies, Inc. Seal structures for wet/dry automatic injectors
US7621887B2 (en) 2000-10-10 2009-11-24 Meridian Medical Technologies, Inc. Wet/dry automatic injector assembly
US20040138611A1 (en) * 2000-10-10 2004-07-15 Meridian Medical Technologies, Inc. Wet/dry automatic injector assembly
US7544189B2 (en) 2000-10-10 2009-06-09 Meridian Medical Technologies, Inc. Needle and hub assembly for automatic injector
US8187220B2 (en) 2000-10-10 2012-05-29 Meridian Medical Technologies, Inc. Seal structures for wet/dry automatic injectors
US20050187532A1 (en) * 2004-02-24 2005-08-25 Medex, Inc. Diaphragm-based reservoir for a closed blood sampling system
US8784399B2 (en) 2005-01-12 2014-07-22 Biogen Idec Ma Inc. Method for delivering interferon-β
US9452106B2 (en) 2005-01-12 2016-09-27 Biogen Ma Inc Method for delivering interferon-β
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