US4146719A - Piperazinyl derivatives of quinoline carboxylic acids - Google Patents

Piperazinyl derivatives of quinoline carboxylic acids Download PDF

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US4146719A
US4146719A US05878600 US87860078A US4146719A US 4146719 A US4146719 A US 4146719A US 05878600 US05878600 US 05878600 US 87860078 A US87860078 A US 87860078A US 4146719 A US4146719 A US 4146719A
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Tsutomu Irikura
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Kyorin Pharmaceutical Co Ltd
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Abstract

This invention relates to new compounds of value as antibacterial agent. More particularly, it relates to piperazinyl derivatives of quinoline carboxylic acids, the hydrates, and the acid addition salts thereof.

Description

DETAILED DESCRIPTION OF THE INVENTION

Antibacterial agent such as nalidixic acid has been proved highly effective in the therapy of infections due to gram-negative bacteria, but such agent suffers from the serious drawback of being ineffective against numerous strains of bacteria, e.g., most gram-positive bacteria and Pseudomonas aeruginosa, of which infection has progressively increased for the last two decades and is one of the infections which are extremely refractory to chemotherapy. The compounds of the present invention are particularly useful in that they possess potent antibacterial activity against both gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa.

The new compounds of the present invention are quinoline carboxylic acid derivative having the formula; ##STR1## the hydrates and the acid addition salts thereof, such as the hydrochloride.

The products of the present invention are prepared by heating piperazine with an acid having the formula; ##STR2## in a non-reactive solvent such as, for example, water, alcohol, pyridine, picoline, N,N-dimethylformamide, dimethylsulfoxide, hexamethylphosphoric triamide, or the like, or in the absence of a solvent, at a temperature between about room temperature and about 200° C., preferably between about 100° and 180° C.

The following examples serve to illustrate the invention.

EXAMPLE 1 Preparation of 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid pentahydrate (I)

A mixture of 1-ethyl-6-fluoro-7-chloro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (1.9g), piperazine hexahydrate (15g) and water (15 ml) was heated at 170° C. in a sealed tube for 16 hr. After evaporation of the solvent, the residue was acidified with diluted hydrochloric acid, heated at 100° C., and the hot solution was filtered. The filtrate was evaporated to dryness. The residue was dissolved in 10% sodium hydroxide and neutralized with acetic acid. The precipitate was collected, washed with water, dried, and recrystallized from ethanol to give 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid pentahydrate (I) as colorless powder, m.p.: 226°-227° C. Mass spectrum m/e: 319 (M+).

EXAMPLE 2 Preparation of 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid (II)

The compound (I) was dried at 100°-200° C. in vacuo to give 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid (II) as colorless powder, m.p.: 215°-220° C. Mass spectrum m/e: 319 (M+), 275 (M+ -CO2).

EXAMPLE 3 Preparation of 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride (III)

The compound (I) or (II) was dissolved in ethanol and acidified with concentrated hydrochloric acid. The resulting precipitate was collected, washed with ethanol, and dried to give 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride (III) as colorless needles, m.p. above 300° C.

______________________________________             C      H      N______________________________________Anal. Calcd. for C.sub.16 H.sub.19 O.sub.3 N.sub.3 C1F               54.01    5.38   11.81Found:              53.85    5.43   11.62______________________________________
EXAMPLE 4 Preparation of 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid (II) and the hydrate (I)

A mixture of 1-ethyl-6-fluoro-7-chloro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (22g) and piperazine hexahydrate (160g) was heated at 135°-145° C. in an autoclave for 18.5 hr. The mixture was evaporated to dryness and dissolved in 10% sodium hydroxide. The solution was neutralized with acetic acid. The precipitate was collected, washed with water, dissolved in 30% acetic acid, and filtered. The filtrate was neutralized with 10% sodium hydroxide. The resulting precipitate was collected, washed with water and ethanol, and dried at 140°-145° C. in vacuo for 1.5 hr. to give 14g (54%) of 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid (II) as colorless powder, m.p. 227°-228° C.

______________________________________             C      H      N______________________________________Anal. Calcd. for C.sub.16 H.sub.18 O.sub.3 N.sub.3 F:               60.18    5.68   13.16Found:              60.31    5.70   13.24______________________________________

The compound (II) was dissolved in 10% sodium hydroxide and neutralized with acetic acid. The precipitate was washed with water and dried at room temperature to afford 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrate (I) as colorless powder, m.p.: 226°-227° C.

______________________________________             C      H      N______________________________________Anal. Calcd. for C.sub.16 H.sub.18 O.sub.3 N.sub.3 F . 5H.sub.2 O:               46.94    6.89   10.26Found:              47.34    6.68   10.30______________________________________
EXAMPLE 5 Preparation of 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid (II)

A mixture of 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid (0.45g), piperazine (0.73g), and β-picoline (4 ml) was heated at 140°-145° C. for 8 hr. The reaction mixture was treated in the same way as described in EXAMPLE 4 to give 0.34g (64%) of 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid (II) as colorless powder, m.p.: 224°-226° C.

It is known that most of drugs such as Quinoform and Ethambutol which form chelates with metal ions in vivo produce undesirable side effects. It was reported that nalidixic acid afforded chelate compound when treated with ferric ion (Chem. Abstr., 62, 15600h (1965)). When nalidixic acid was mixed with one third molar equivalent of ferric chloride hexahydrate in the presence of a molar equivalent of sodium hydroxide in water, the absorption maxima at 256 and 326 nm of nalidixic acid shifted to shorter wave length at 248 and 311 nm, respectively, and 3:1 chelate compound of nalidixic acid and ferric ion was obtained.

On the other hand, the compound (II) of the present invention did not give any chelate compound when treated with ferric ion under the above condition.

Usefulness of the compounds of the present invention as antibacterial agent has been demonstrated by the following experiments.

Experiment 1 Antibacterial activity (in vitro)

The minimum inhibitory conceptration (M.I.C.) of the compound (II) was assayed by the agar dilution streak method against four strains of Pseudomonas aeruginosa and other pathogenic bacteria. As shown in Table 1, nalidixic acid and pipemidic acid exerted antibacterial activity mainly on gram-negative bacteria and were inactive on many strains of gram-positive bacteria and many Pseudomonas aeruginosa strains, those are gram-negative. On the other hand, the compound (II) was more active than nalidixic acid and pipemidic acid against both of gram-positive and gram-negative bacteria, and it was proved to be more active than gentamicin and carbenicillin against gram-negative bacteria including Pseudomonas aeruginosa.

The compound (II) showed a broad spectrum of activity against gram-positive and gram-negative bacteria, and it inhibited even such bacteria those were not susceptible to nalidixic acid, pipemidic acid and carbenicillin.

Thus, the compound (II) is promising antibacterial agent being more potent and broader antibacterial activity against pathogenic bacteria including Pseudomonas aeruginosa than other synthetic chemotherapeutic agents.

                                  Table 1__________________________________________________________________________Antibacterial Spectrum                M.I.C. (μg/ml)                CompoundOrganisms        Grams                (II)  PPA NA  GM CBPC__________________________________________________________________________Bacillus subtilis PCI 219            +   0.39  6.25                          6.25                              0.10                                 0.39Staphylococcus aureus 209P            +   0.78  25  100 0.10                                 0.39Sta. aureus ATCC 14775            +   1.56  100 >100                              0.10                                 6.25Streptococcus pyogenes IID 692            +   3.13  >100                          >100                              6.25                                 0.10Str. pyogenes S-8            +   1.56  >100                          >100                              6.25                                 0.10Str. faecalis IID 682            +   3.13  --  --  50 100Diplococcus pneumoniae IID 552            +   12.5  >100                          >100                              12.5                                 0.39Corynebacterium pyogenes IID 548            +   3.13  100 --  0.78                                 0.20Mycobacterium phlei IFO 3142            +   0.39  12.5                          100 6.25                                 >200My. smegmatis IFO 3083            +   1.56  50  >100                              0.20                                 6.25Escherichia coli NIHJ            -   0.10  1.56                          3.13                              0.39                                 1.56E. coli ATCC 10536            -   0.05  1.56                          3.13                              0.39                                 1.56 Proteus vulgaris IFO 3167            -   0.05  3.13                          3.13                              0.20                                 6.25Pr. vulgaris XK Denken            -   0.20  6.25                          3.13                              0.10                                 0.39Klebsiella pneumoniae IFO 3512            -   0.05  1.56                          1.56                              0.20                                 >200Salmonella enteritidis IID 604            -   0.20  12.5                          12.5                              1.56                                 12.5Shigella sonnei IID 969            -   0.10  1.56                          1.56                              0.78                                 1.56Haemophilus influenzae IID 986            -   0.05  3.13                          1.56                              1.56                                 0.39Neisseria perflava IID 856            -   0.05  1.56                          1.56                              0.78                                 1.56Pseudomonas aeruginosa V-1            -   0.39  12.5                          100 0.78                                 12.5Ps. aeruginosa IFO 12689            -   1.56  25  >200                              12.5                                 100Ps. aeruginosa IID 1210            -   1.56  50  >200                              12.5                                 100Ps. aeruginosa IID 1130            -   0.78  25  >200                              3.13                                 200__________________________________________________________________________ PPA : Pipemidic acid; NA : Nalidixic acid; GM : Gentamicin; CBPC : Carbenicillin
Experiment 2 Preventive effect of the compound (II) against systemic infection with Pseudomonas aeruginosa in mice

Systemic infection was produced by inoculating male mice (strain: ddY, 6 weeks old, body weight: 28-33g) in intraperitoneally with Pseudomonas aeruginosa IID 1210 suspended in 0.5 ml of Brain heart infusion broth (Eiken) containing 5% mucin. The compound (II) and pipemidic acid were suspended in 0.5% carboxymethyl cellulose solution, respectively, and carbenicillin was dissolved in water. Each of these test materials was administered to the mice twice, immediately after and then 6 hours after the inoculation, and the therapeutic effect of each compounds was judged from the survival rate. A comparison of compound efficacy was made by 50% effective dose (ED50) calculated by probit analysis (1) and a 95% confidence limit that was calculated by the method of Litchfield and Wilcoxon (2). As shown in Table 2, the compound of EXAMPLE 2 effectively protected the mice from Pseudomonas aeruginosa infection, and it was confirmed that it was more potent than pipemidic acid and carbenicillin. LD10 of the compound (II) is over 4g/kg in mice and so the compound (II) is excellent in safety zone (LD10 /ED90 = over 21.6).

(1) Miller L. C. and M. L. Tainter: Estimation of the ED50 and its error by means of logarithmic-probit graph paper Proc. Soc. Exp. Biol. Med. 57 261-264 (1944)

(2) Litchfield J. T. and F. Wilcoxon: A simplified method of evaluating dose - effect J. Pharmacol. 92 99-113 (1948)

              Table 2______________________________________Preventive effect of the compound (II) againstsystemic infection with Pseudomonas aeruginosain mice                  ED.sub.50 (mg/kg)      Challenge dose                  (95% confidence                               ED.sub.90Compounds  (cells/mouse)                  limit)       ED.sub.90 (mg/kg)______________________________________Compound (II)      3.5 × 10.sup.4                  98.0(79.7-120.5)                                185Pipemidic acid      3.5 × 10.sup.4                  400(317-504) 1120Carbenicillin      3.5 × 10.sup.4                  800(630-1,016)                               1430______________________________________ Compound (II) and Pipemidic acid were administered orally, Carbenicillin was administered subcutaneously.
Experiment 3 Preventive effect of the compound (II) against ascending kidney infection in mice with Escherichia coli

Ascending kidney infection was induced in female mice (strain: ddY, 6 weeks old, body weight: 22-26g), by instilling Escherlichia coli NIHJ JC-2 suspended in 0.04 ml of Tryptosoya broth (Nissan) into the urinary tract of mice anesthetized with sodium pentobarbital and by holding for 6 hours the mice in plastic tubes (diameter 25 mm) and clamping the outlet of urinary tract.

The compound (II), nalidixic acid and pipemidic acid were suspended in 0.5% carboxy methyl cellulose solution, respectively. Each of these test material was orally administered 3 hours after inoculation. Mice were sacrificed 48 hours after inoculation. Kidneys were removed aseptically and bisected, and the two halves were pressed and streaked on agar plate containing Desoxycholate medium (Nissan). The therapeutic effect of each compound was evaluated from the absence of growth on the agar surface after 20 hours of incubation at 37° C. A comparison of compound efficacy was made by 50% effective dose (ED50) calculated by probit analysis and a 95% confidence limit that was calculated by the method of Litchfield and Wilcoxon.

As shown in Table 3, the compound of EXAMPLE 2 was effective against ascending kidney infection with Escherichia coli in mice and it was confirmed that the compound (II) was more potent than nalidixic acid and pipemidic acid.

LD10 of the compound (II) is over 4 g/kg in mice and the compound (II) is excellent in safety zone (LD10 /ED90 = over 65.6).

              Table 3______________________________________Preventive effect of the compound (II) againstascending kidney infection with Escherichia coli -in mice                  ED.sub.50 (mg/kg)      Challenge dose                  (95% confidence                               ED.sub.90Compounds  (cells/mouse)                  limit)       (mg/kg)______________________________________Compound (II)      3.2 × 10.sup.7                  15.0 (8.6 - 26.3)                                61Nalidixic acid      3.2 × 10.sup.7                  86.0 (45.3 - 163)                               345Pipemidic acid      3.2 × 10.sup.7                  74.0 (51.0 - 107)                               235______________________________________
Experiment 4 Concentrations of the compound (II) in serum after a single oral administration of 50 mg/kg in rats

Concentrations of the compound (II) in serum were determined by microbiological assay. Nutrient agar was heated and melted. Escherichia coli NIHJ JC-2 was added to melted agar, and well mixed, and 5 ml of the mixture was placed in Petri dish. Penicylinders were placed on the solidified agar, and the cylinder was filled with serum sample. The plate was placed in the incubator of 37° C. for 20 hours. The diameter of the inhibition zone was measured. The serum was sampled at 0.5, 1, 2, 4, and 6 hours after giving the compound (II) in rat.

The serum concentrations of compound (II) after a single oral administration of 50 mg/kg were shown in Table 4. Absorption of the compound (II) was rapid, and the concentration peak was at 30 min. after oral administration. The antibacterial activity of the compound (II) was not decreased by serum.

              Table 4______________________________________Serum concentration of compound (II) aftera single oral administration of 50 mg/kg in ratTime afteradministration       Concentration μg/ml______________________________________0.5         0.87 ± 0.111           0.77 ± 0.132           0.52 ± 0.104           0.23 ± 0.026           0.11 ± 0.01______________________________________
Experiment 5 Concentrations of compound (II) in serum at 30 min. after a single oral administration in rats

The concentrations of compound (II) in serum of rats at 30 minutes after a single oral administration were shown in Table 5. The concentrations of compound (II) in serum were assayed by the microbiological method described in the experiment 4.

The antibacterial activity of the compound (II) was not decreased by serum. Serum concentration of the compound depended on the dose from 25 mg/kg to 400 mg/kg.

              Table 5______________________________________Concentration of compound (II) in serum at 30 min.after a single oral administration in ratsDose       Concentration (μg/ml)(mg/kg)    mean ± S.E.______________________________________ 25        0.31 ± 0.04 50        0.87 ± 0.11100        1.42 ± 0.23200        2.23 ± 0.30400        3.37 ± 0.35______________________________________
Experiment 6 The concentration ratio of the compound (II) in serum to minimum inhibitory concentration (M.I.C.) on pathogenic bacteria after oral administration of 50 mg/kg in rats

The concentration ratios of compound (II), nalidixic acid and pipemidic acid in serum of rats to M.I.C. on pathogenic bacteria were shown in FIGS. 1-3, respectively.

As shown in FIGS. 1-3, the absorption of the compound (II) was rapid, and the serum concentrations were 18 times of M.I.C. on Escherichia coli at 30 minutes and 2 times at 6 hours after oral administration. On the other hand, the concentration ratios of halidixic acid and pipemidic acid were smaller than that of the compound (II) and serum levels of pipemidic acid were maintained till only 2 hours after oral administration.

The compound (II) could be expected to take more effect than nalidixic acid and pipemidic acid against infections of the preceding bacteria. In addition, the compound (II) could be expected to take more effect than those of nalidixic acid and pipemidic acid against infections of Pseudomonas aeruginosa and gram-positive bacteria.

Experiment 7 Concentrations of compound (II) in tissues after a single oral administration of 50 mg/kg in rats

Concentrations of compound (II) in tissues were assayed by the microbiological method described in the experiment 4 except using tissue homogenate instead of serum. The tissue homogenates were prepared with 1:4 homogenates in M/15 phosphate buffer (pH 7.5). Free concentration was calculated from standard curve of the compound (II) in M/15 phosphate buffer. Total concentration was calculated from standard curve of the compound (II) in tissue homogenate. The tissue concentrations of compound (II) after a single oral administration of 50 mg/kg were shown in Tables 6 and 7.

Antibacterial activity of the compound (II) was decreased by liver and kidney homogenate.

              Table 6______________________________________Concentration of compound (II) in tissues aftera single oral administration of 50 mg/kg in rats(Free concentration)           Tissue level (μg/g)0.5        1        2        4      6 (hrs.)______________________________________Liver 4.1±0.9          3.7±0.6                   2.5±0.5                          1.2±0.2                                 0.7±0.1Kidney 7.4±1.4          6.8±1.2                   4.4±0.6                          1.9±0.2                                 1.0±0.1______________________________________ mean ± S.E.

______________________________________(Total concentration)           Tissue level (μg/g)0.5        1        2        4      6 (hrs.)______________________________________Liver  9.0±1.9           7.9±1.2                   5.4±1.0                          2.6±0.4                                 1.5±0.2Kidney 11.1±2.1          10.3±2.0                   6.5±0.9                          3.5±0.9                                 1.4±0.1______________________________________ mean ± S.E.
Experiment 8 Tissue levels of 14 C-labeled compound (II) in rats after oral administration

Distribution of compound (II) was studied in rats orally given a single dose of 50 mg 14 C-compound (II)/kg. Tissue levels of compound (II) at 30 minutes after administration were shown in Table 8.

              Table 8______________________________________Tissue levels of .sup.14 C-compound (II) in ratsafter oral administration (50 mg .sup.14 C-compound/kgTissue          30 min. after administration______________________________________Blood            1.41±0.44                      μgEq/mlLung             1.91±0.48                      μgEq/gLiver           11.09±4.78                      "Kidney          11.42±2.40                      "Bladder         15.0±20.28                      "Bone             0.73±0.28                      "______________________________________
Experiment 9 Billiary excretion in rats after a single oral administration of 50 mg/kg of the compound (II)

The concentrations of compound (II) in bile of rats after a single oral administration of 50 mg/kg were shown in Table 9, and the cumulative recovery was shown in Table 10. The compound (II), nalidixic acid and pipemidic acid concentrations in bile were assayed by the microbiological method described in the experiment 4.

The biliary levels and cumulative excretion of compound (II) were more excellent than those of nalidixic acid and pipemidic acid. The antibacterial activity of the compound (II), nalidixic acid and pipemidic acid was not influenced by bile of rats.

              Table 9______________________________________The concentrations of compound (II) inbile after a single oral administrationof 50 mg/kg in ratsTime after   Biliary level (μg/ml) mean±S.E.administra-            Nalidixic                           Pipemidiction (hrs.)   Compound (II)  acid     acid______________________________________0-3     31.0±3.5    14.7±1.5                           27.4±2.63-6     26.4±3.2    16.6±2.4                           22.6±1.7 6-24   18.9±1.6     9.3±1.6                           10.2±1.224-27    6.7±0.9    --*      --*______________________________________ --* Not detected (<2 μg/ml)

              Table 10______________________________________The biliary excretion in rats aftera single oral administration of 50 mg/kgof the compound (II)Time after    Cumulative recovery (%) mean ±S.E.administration         Nalidixic Pipemidic(hours)  Compound (II) acid      acid______________________________________0-3      0.60±0.06  0.29±0.03                            0.60±0.070-6      1.02±0.11  0.56±0.05                            1.01±0.10 0-24    2.43±0.23  1.33±0.10                            1.97±0.09 0-27    2.50±0.23  1.33±0.10                            1.97±0.09______________________________________
Experiment 10 Concentrations of compound (II) in urine of rats and mice after a single oral administration

As shown in Table 11, the concentrations of compound (II) in urine were assayed by the microbiological method described in the Experiment 4. The compound transferred to urine rapidly and the concentrations peak was observed at 0-6 hours.

              Table 11______________________________________Concentrations of compound (II) in urine ofrats and mice after a single oral administration  Time afterDose   administration             Urinary level (μg/ml) mean ±S.E.(mg/kg)  (hours)    Rat          Mouse______________________________________1.56   0-3        1.36±0.14 0.53±0.06  3-6        0.93±0.14 0.22±0.04   6-24      0.17±0.05 0.04±0.03  24-27      0.04±0.01 0.03±0.023.13   0-3        3.39±0.55 1.76±0.19  3-6        3.78±0.44 1.46±0.23   6-24      0.58±0.09 0.27±0.04  24-27      0.03±0    0.14±0.016.25   0-3        9.69±2.30 3.70±0.26  3-6        8.08±1.50 2.04±0.13   6-24      1.36±0.20 3.01±0.17  24-27      0.04±0    0.38±0.0512.5   0-3        21.9±3.6  10.3±0.9  3-6        16.8±1.6  8.3±0.7   6-24      4.0±0.5   7.4±0.8  24-27      0.06±0.02 1.2±0.125.0   0-3        56.8±11.1 16.2±3.3  3-6        46.4±3.8  20.3±1.7   6-24      13.5±3.0  11.7±0.9  24-27      1.2±0.5   2.5±0.250.0   0-3        89.3±19.5 33.1±2.8  3-6        99.2±15.9 27.2±3.2   6-24      32.2±0.1  23.1±2.0  24-27      3.1±0.9   7.7 ±1.1______________________________________
Experiment 11 Acute toxicity

Acute toxicity of the compound (II) was examined in mice (ddY strain, 7 weeks old) and rats (Wistar strain, body weight 180-230 g). Observation period was 10 days, respectively, after a single oral, subcutaneous and intravenous administration. The LD50 value was determined by the Litchfield-Wilcoxon method. The results were shown in Table 12.

              Table 12______________________________________The LD.sub.50 values of the compound (II)   Route of             LD.sub.50 mg/kgAnimal  administration               Sex      (95% confidence limit)______________________________________Mice    oral        male     >4,000               female   >4,000   subcutaneous               male     >1,500               female   >1,500   intravenous male     210 (194-227)               female   (207-236)Rats    oral        male     >4,000               female   >4,000   subcutaneous               male     >1,500               female   >1,500   intravenous male     305 (288-323)______________________________________
Experiment 12 Subacute toxicity study

Subacute toxicity study of the compound (II) was carried out in rats by administering orally 250, 500 and 1000 mg/kg for 1 month. As the results, no effects of the test compound were observed in general symptom, food and water consumptions, body weight, hematological analysis, hematobiochemical analysis, the differential counts of myelocytes, biochemical analysis of liver and kidney, urinary analysis, organ weight, gross observation and histopathological findings.

Experiment 13 Effects on chromosome

The effects of the compound (II) on chromosome of myelocytes were tested by administering orally 250 and 500 mg/kg in Chinese hamster one time, and 1000 mg/kg in rats for 1 month. As the results, no effects of the test compound on chromosome of myelocytes were observed in both species.

Experiment 14 Teratogenicity study

Teratological study of the compound (II) was carried in mice by administering orally 500 and 1000 mg/kg during the period of organogenesis. As the results, teratogenic agent was not detected in the compound (II).

Claims (4)

What is claimed is:
1. A compound having the formula ##STR3## the hydrates, and the hydrochloride acid addition salts thereof.
2. 1-Ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid.
3. 1-Ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid pentahydrate.
4. 1-Ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride.
US05878600 1977-05-16 1978-02-16 Piperazinyl derivatives of quinoline carboxylic acids Expired - Lifetime US4146719A (en)

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FR (1) FR2391210B1 (en)
GB (1) GB1574285A (en)

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DE3031767A1 (en) * 1979-08-22 1981-03-26 Kyorin Seiyaku Kk Quinolinecarboxylic, process for their production and their use
US4292317A (en) * 1977-09-20 1981-09-29 Laboratorie Roger Bellon 1,4-Dihydro-quinoline-3-carboxylic acid derivatives, process for their preparation and compositions containing them
US4352803A (en) * 1978-08-25 1982-10-05 Dainippon Pharmaceutical Co., Ltd. Novel naphthyridine derivatives, intermediates thereof, processes for preparation thereof, and use thereof
US4398029A (en) * 1981-02-19 1983-08-09 Kyorin Seiyaku Kabushiki Kaisha Quinoline carboxylic acid derivatives and process for the preparation
US4404197A (en) * 1981-05-15 1983-09-13 Fox Jr Charles L Antimicrobial compositions containing 1-ethyl-6-fluoro-1,4-dihydro-4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid or metal salts thereof and silver sulfadiazine
EP0090424A1 (en) * 1982-03-31 1983-10-05 Sterling Drug Inc. New quinolone compounds and preparation thereof
US4416884A (en) * 1978-04-12 1983-11-22 Otsuka Pharmaceutical Co., Ltd. Piperazinylbenzoheterocyclic compounds
US4442101A (en) * 1981-02-13 1984-04-10 Dainippon Pharmaceutical Co., Ltd. Sesquihydrate of naphthyridine derivative, and process for the preparation thereof
US4448962A (en) * 1978-09-29 1984-05-15 Kyorin Seiyaku Kabushiki Kaisha Substituted quinoline carboxylic acid derivatives
US4455310A (en) * 1981-06-10 1984-06-19 Kanebo Ltd. Quinolinecarboxylic acid derivative, and antibacterial agent containing said compound as active ingredient
US4472579A (en) * 1980-09-05 1984-09-18 Kyorin Seiyaku Kabushiki Kaisha Process for the preparation of quinoline carboxylic acid derivatives
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WO1985001208A1 (en) * 1983-09-12 1985-03-28 Research Corporation Antimicrobial compositions containing 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid or metal salts thereof and silver sulfadiazine
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US4528287A (en) * 1983-09-19 1985-07-09 Hokuriku Pharmaceutical Co., Ltd. 6-Fluoro-1, 4-dihydro-4-oxo-7-substituted piperazinylquinoline-3-carboxylic acids and the method for preparing the same
US4544747A (en) * 1979-02-26 1985-10-01 Otsuka Pharmaceutical Company, Limited Quinoline carboxylic acid derivatives
US4551456A (en) * 1983-11-14 1985-11-05 Merck & Co., Inc. Ophthalmic use of norfloxacin and related antibiotics
US4563459A (en) * 1982-12-29 1986-01-07 Bayer Aktiengesellschaft Microbicidal agents based on quinolonecarboxylic acid
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
US4670444A (en) * 1980-09-03 1987-06-02 Bayer Aktiengesellschaft 7-amino-1-cyclopropyl-4-oxo-1, 4-dihydro-quinoline-and naphthyridine-3-carboxylic acids and antibacterial agents containing these compounds
US4687770A (en) * 1985-12-23 1987-08-18 Abbott Laboratories Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives
US4689325A (en) * 1985-12-23 1987-08-25 Abbott Laboratories Isoxazolo-pyrido-phenoxazine and isothiazolo-pyrido-phenoxazine derivatives
US4692454A (en) * 1986-02-03 1987-09-08 Warner-Lambert Company Opthalmic use of quinolone antibiotics
US4698350A (en) * 1984-09-17 1987-10-06 Sterling Drug Inc. 1-ethyl-6-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid and antibacterial use thereof
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
US4758567A (en) * 1985-11-19 1988-07-19 Rottapharm S.P.A. 7-(4-amino-piperazinyl)- or 7-(4-chloro-piperazinyl)quinolinone and azaquinolinone derivatives and pharmaceutical compositions containing them
US4775668A (en) * 1985-09-18 1988-10-04 Pfizer Inc. Substituted bridged-diazabicycloalkyl quinolone carboxylic acids and anti-bacterial use thereof
US4792552A (en) * 1986-10-30 1988-12-20 Abic Ltd. Water-soluble adduct of norfloxacin
US4851535A (en) * 1985-01-23 1989-07-25 Toyama Chemical Co., Ltd. Nicotinic acid derivatives
WO1989006649A2 (en) 1988-01-25 1989-07-27 Warner-Lambert Company Antibacterial agents
DE3917904A1 (en) * 1988-06-17 1990-05-03 Korea Advanced Inst Sci & Tech New 5-fluoro-4-halo-1-nitro-benzoyl-acetic acid cpds. - useful as intermediates for antibacterial quinolone derivs.
US5037834A (en) * 1987-12-18 1991-08-06 Pfizer Inc. Heterocycylic-substituted quinoline-carboxylic acids
EP0249620B1 (en) * 1985-12-09 1992-11-19 CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. Process for the preparation of quinoline carboxylic acids
US5180719A (en) * 1988-10-24 1993-01-19 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl lactam esters
US5214051A (en) * 1989-08-01 1993-05-25 Pfizer Inc. Thiazolyl and oxazolyl[5,4-c]piperidyl-substituted quinolone-carboxylic acid and related analogs thereof having antibacterial properties are disclosed
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
US5328908A (en) * 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
US5387748A (en) * 1988-10-24 1995-02-07 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial dithiocarbamoyl quinolones
US5434147A (en) * 1988-10-24 1995-07-18 Proctor & Gamble Pharmaceuticals, Inc. Antimicrobial quinolonyl lactam esters
US5491139A (en) * 1988-10-24 1996-02-13 The Procter & Gamble Company Antimicrobial quinolonyl lactams
US5496947A (en) * 1993-08-13 1996-03-05 Dong Wha Pharmaceutical Industrial Co., Ltd. Quinolone carboxylic acid derivatives
US5498615A (en) * 1993-04-24 1996-03-12 Korea Research Institute Of Chemical Technology Quinolone carboxylic acid derivatives and process for preparing the same
US5530116A (en) * 1990-04-18 1996-06-25 The Procter & Gamble Company Antimicrobial quinolonyl lactams
US5585491A (en) * 1988-01-25 1996-12-17 Otsuka Pharmaceutical Co., Ltd. Antibacterial agents
US5602254A (en) * 1995-05-26 1997-02-11 Warner-Lambert Company Method for making quinoline carboxylic acids or naphthyridine carboxylic acids in free base form
US5637580A (en) * 1988-10-24 1997-06-10 The Procter & Gamble Company Antimicrobial penem-quinolones
US5679336A (en) * 1991-09-17 1997-10-21 Alcon Laboratories, Inc. Antibacterial compositions
US5719157A (en) * 1993-06-29 1998-02-17 Takeda Chemical Industries, Ltd. Pharmaceutical composition containing quinoline or quinazoline derivatives
US5817820A (en) * 1993-12-09 1998-10-06 Korea Research Institute Of Chemical Technology Quinolone derivatives and processes for the preparation thereof
US5910498A (en) * 1994-10-20 1999-06-08 Wakunaga Seiyaku Kabushiki Kaisha Pyridonecarboxylic acid derivatives or salts thereof and antibacterial agents comprising the same as active ingredient
US6211375B1 (en) 1996-04-19 2001-04-03 Wakunaga Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivatives or salts thereof and antibacterial agents containing the same as the active ingredient
US6313299B1 (en) 1997-06-26 2001-11-06 Dong Wha Pharmaceutical Industrial Co., Ltd. Quinolone carboxylic acid derivatives
US20040073030A1 (en) * 2000-05-09 2004-04-15 Pulla Reddy Muddasani Process for the preparation of quinolone derivatives
EP2138490A1 (en) 2007-05-24 2009-12-30 Biocodex New method for synthesis of fluoroquinolones

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US4292317A (en) * 1977-09-20 1981-09-29 Laboratorie Roger Bellon 1,4-Dihydro-quinoline-3-carboxylic acid derivatives, process for their preparation and compositions containing them
US4416884A (en) * 1978-04-12 1983-11-22 Otsuka Pharmaceutical Co., Ltd. Piperazinylbenzoheterocyclic compounds
US4352803A (en) * 1978-08-25 1982-10-05 Dainippon Pharmaceutical Co., Ltd. Novel naphthyridine derivatives, intermediates thereof, processes for preparation thereof, and use thereof
US4359578A (en) * 1978-08-25 1982-11-16 Dainippon Pharmaceutical Co., Ltd. Naphthyridine derivatives and salts thereof useful as antibacterial agents
US4448962A (en) * 1978-09-29 1984-05-15 Kyorin Seiyaku Kabushiki Kaisha Substituted quinoline carboxylic acid derivatives
US4544747A (en) * 1979-02-26 1985-10-01 Otsuka Pharmaceutical Company, Limited Quinoline carboxylic acid derivatives
DE3031767A1 (en) * 1979-08-22 1981-03-26 Kyorin Seiyaku Kk Quinolinecarboxylic, process for their production and their use
US4670444A (en) * 1980-09-03 1987-06-02 Bayer Aktiengesellschaft 7-amino-1-cyclopropyl-4-oxo-1, 4-dihydro-quinoline-and naphthyridine-3-carboxylic acids and antibacterial agents containing these compounds
US4472579A (en) * 1980-09-05 1984-09-18 Kyorin Seiyaku Kabushiki Kaisha Process for the preparation of quinoline carboxylic acid derivatives
US4522819A (en) * 1980-10-02 1985-06-11 Norwich Eaton Pharmaceuticals, Inc. 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid and metal salts thereof useful in burn therapy
US4496566A (en) * 1980-12-24 1985-01-29 Dainippon Pharmaceutical Co., Ltd. Naphthyridine derivatives
US4442101A (en) * 1981-02-13 1984-04-10 Dainippon Pharmaceutical Co., Ltd. Sesquihydrate of naphthyridine derivative, and process for the preparation thereof
US4398029A (en) * 1981-02-19 1983-08-09 Kyorin Seiyaku Kabushiki Kaisha Quinoline carboxylic acid derivatives and process for the preparation
US4404197A (en) * 1981-05-15 1983-09-13 Fox Jr Charles L Antimicrobial compositions containing 1-ethyl-6-fluoro-1,4-dihydro-4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid or metal salts thereof and silver sulfadiazine
US4455310A (en) * 1981-06-10 1984-06-19 Kanebo Ltd. Quinolinecarboxylic acid derivative, and antibacterial agent containing said compound as active ingredient
US4499091A (en) * 1982-03-31 1985-02-12 Sterling Drug Inc. 1-Amino (or substituted amino)-1,4-dihydro-4-oxo-6-fluoro-7-heterylquinoline-3-carboxylic acids and their use as antibacterial agents
EP0090424A1 (en) * 1982-03-31 1983-10-05 Sterling Drug Inc. New quinolone compounds and preparation thereof
US4563459A (en) * 1982-12-29 1986-01-07 Bayer Aktiengesellschaft Microbicidal agents based on quinolonecarboxylic acid
WO1985001208A1 (en) * 1983-09-12 1985-03-28 Research Corporation Antimicrobial compositions containing 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid or metal salts thereof and silver sulfadiazine
US4528287A (en) * 1983-09-19 1985-07-09 Hokuriku Pharmaceutical Co., Ltd. 6-Fluoro-1, 4-dihydro-4-oxo-7-substituted piperazinylquinoline-3-carboxylic acids and the method for preparing the same
US4551456A (en) * 1983-11-14 1985-11-05 Merck & Co., Inc. Ophthalmic use of norfloxacin and related antibiotics
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
US4698350A (en) * 1984-09-17 1987-10-06 Sterling Drug Inc. 1-ethyl-6-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid and antibacterial use thereof
US4851535A (en) * 1985-01-23 1989-07-25 Toyama Chemical Co., Ltd. Nicotinic acid derivatives
US4775668A (en) * 1985-09-18 1988-10-04 Pfizer Inc. Substituted bridged-diazabicycloalkyl quinolone carboxylic acids and anti-bacterial use thereof
US4861779A (en) * 1985-09-18 1989-08-29 Pfizer Inc. Anti-bacterial substituted bridged-diazabicycloalkyl quinolone carboxylic acids
US4758567A (en) * 1985-11-19 1988-07-19 Rottapharm S.P.A. 7-(4-amino-piperazinyl)- or 7-(4-chloro-piperazinyl)quinolinone and azaquinolinone derivatives and pharmaceutical compositions containing them
EP0249620B1 (en) * 1985-12-09 1992-11-19 CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. Process for the preparation of quinoline carboxylic acids
US4689325A (en) * 1985-12-23 1987-08-25 Abbott Laboratories Isoxazolo-pyrido-phenoxazine and isothiazolo-pyrido-phenoxazine derivatives
US4687770A (en) * 1985-12-23 1987-08-18 Abbott Laboratories Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives
US4692454A (en) * 1986-02-03 1987-09-08 Warner-Lambert Company Opthalmic use of quinolone antibiotics
US4792552A (en) * 1986-10-30 1988-12-20 Abic Ltd. Water-soluble adduct of norfloxacin
US5037834A (en) * 1987-12-18 1991-08-06 Pfizer Inc. Heterocycylic-substituted quinoline-carboxylic acids
WO1989006649A3 (en) * 1988-01-25 1989-12-28 Warner Lambert Co Antibacterial agents
EP0326891A3 (en) * 1988-01-25 1990-04-25 Warner-Lambert Company Antibacterial agents
WO1989006649A2 (en) 1988-01-25 1989-07-27 Warner-Lambert Company Antibacterial agents
EP0326891A2 (en) * 1988-01-25 1989-08-09 Warner-Lambert Company Antibacterial agents
US5585491A (en) * 1988-01-25 1996-12-17 Otsuka Pharmaceutical Co., Ltd. Antibacterial agents
DE3917904A1 (en) * 1988-06-17 1990-05-03 Korea Advanced Inst Sci & Tech New 5-fluoro-4-halo-1-nitro-benzoyl-acetic acid cpds. - useful as intermediates for antibacterial quinolone derivs.
US5646139A (en) * 1988-10-24 1997-07-08 The Procter & Gamble Company Antimicrobial carbapenem quinolones
US5648346A (en) * 1988-10-24 1997-07-15 The Procter & Gamble Company Antimicrobial carbacephem-quinolones
US5328908A (en) * 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
US5631256A (en) * 1988-10-24 1997-05-20 The Procter & Gamble Company Antimicrobial quinolone thioureas
US5387748A (en) * 1988-10-24 1995-02-07 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial dithiocarbamoyl quinolones
US5434147A (en) * 1988-10-24 1995-07-18 Proctor & Gamble Pharmaceuticals, Inc. Antimicrobial quinolonyl lactam esters
US5491139A (en) * 1988-10-24 1996-02-13 The Procter & Gamble Company Antimicrobial quinolonyl lactams
US5637580A (en) * 1988-10-24 1997-06-10 The Procter & Gamble Company Antimicrobial penem-quinolones
US5180719A (en) * 1988-10-24 1993-01-19 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl lactam esters
US5656623A (en) * 1988-10-24 1997-08-12 The Procter & Gamble Company Antimicrobial lactam-quinolones
US5672600A (en) * 1988-10-24 1997-09-30 The Procter & Gamble Company Antimicrobial dithiocarbamoyl quinolones
US5385906A (en) * 1988-12-06 1995-01-31 The Upjohn Company Antibacterial quinolone compounds
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
US5214051A (en) * 1989-08-01 1993-05-25 Pfizer Inc. Thiazolyl and oxazolyl[5,4-c]piperidyl-substituted quinolone-carboxylic acid and related analogs thereof having antibacterial properties are disclosed
US5530116A (en) * 1990-04-18 1996-06-25 The Procter & Gamble Company Antimicrobial quinolonyl lactams
US5679336A (en) * 1991-09-17 1997-10-21 Alcon Laboratories, Inc. Antibacterial compositions
US5498615A (en) * 1993-04-24 1996-03-12 Korea Research Institute Of Chemical Technology Quinolone carboxylic acid derivatives and process for preparing the same
US5719157A (en) * 1993-06-29 1998-02-17 Takeda Chemical Industries, Ltd. Pharmaceutical composition containing quinoline or quinazoline derivatives
US5496947A (en) * 1993-08-13 1996-03-05 Dong Wha Pharmaceutical Industrial Co., Ltd. Quinolone carboxylic acid derivatives
US5817820A (en) * 1993-12-09 1998-10-06 Korea Research Institute Of Chemical Technology Quinolone derivatives and processes for the preparation thereof
US5910498A (en) * 1994-10-20 1999-06-08 Wakunaga Seiyaku Kabushiki Kaisha Pyridonecarboxylic acid derivatives or salts thereof and antibacterial agents comprising the same as active ingredient
US5602254A (en) * 1995-05-26 1997-02-11 Warner-Lambert Company Method for making quinoline carboxylic acids or naphthyridine carboxylic acids in free base form
US6211375B1 (en) 1996-04-19 2001-04-03 Wakunaga Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivatives or salts thereof and antibacterial agents containing the same as the active ingredient
US6313299B1 (en) 1997-06-26 2001-11-06 Dong Wha Pharmaceutical Industrial Co., Ltd. Quinolone carboxylic acid derivatives
US6552196B2 (en) 1997-06-26 2003-04-22 Dong Wha Pharmaceutical Industrial Co., Ltd. Quinolone carboxylic acid derivatives
US20040073030A1 (en) * 2000-05-09 2004-04-15 Pulla Reddy Muddasani Process for the preparation of quinolone derivatives
EP2138490A1 (en) 2007-05-24 2009-12-30 Biocodex New method for synthesis of fluoroquinolones

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