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Process for treatment of ascites and device to accomplish same

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US3910283A
US3910283A US40434573A US3910283A US 3910283 A US3910283 A US 3910283A US 40434573 A US40434573 A US 40434573A US 3910283 A US3910283 A US 3910283A
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Prior art keywords
fluid
valve
pressure
diaphragm
device
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Harry H Leveen
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LEVEEN HARRY H
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LEVEEN HARRY H
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22Valves or arrangement of valves
    • A61M39/24Check- or non-return valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00Drainage appliances for wounds or the like, i.e. wound drains, implanted drains
    • A61M27/002Implant devices for drainage of body fluids from one part of the body to another
    • A61M27/006Cerebrospinal drainage; Accessories therefor, e.g. valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22Valves or arrangement of valves
    • A61M39/24Check- or non-return valves
    • A61M2039/242Check- or non-return valves designed to open when a predetermined pressure or flow rate has been reached, e.g. check valve actuated by fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22Valves or arrangement of valves
    • A61M39/24Check- or non-return valves
    • A61M2039/2433Valve comprising a resilient or deformable element, e.g. flap valve, deformable disc
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22Valves or arrangement of valves
    • A61M39/24Check- or non-return valves
    • A61M2039/2433Valve comprising a resilient or deformable element, e.g. flap valve, deformable disc
    • A61M2039/244Hinged closure member, e.g. flap valve
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/04Liquids
    • A61M2202/0401Ascitics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/04Liquids
    • A61M2202/0464Cerebrospinal fluid
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00Fluid handling
    • Y10T137/7722Line condition change responsive valves
    • Y10T137/7837Direct response valves [i.e., check valve type]
    • Y10T137/7879Resilient material valve
    • Y10T137/7888With valve member flexing about securement

Abstract

A method for the transfer of body fluid which accumulates in the peritoneal cavity into the vascular system is disclosed. This accumulation occurs most frequently with patients suffering from cirrhosis of the liver and constitutes a lethal complication. An implant device is disclosed which comprises a plastic chamber and connecting tubing, said chamber containing unique valve structure comprising a flexible diaphragm seated on a shoulder and attached to this diaphragm a connector bar which is attached at its other end to the center plate of a structure composed of several lateral silicone rubber struts which radiate out from the center plate to connect to a circular peripheral ring. The circular peripheral ring is anchored fixedly to the lateral wall of the valve housing by compression between two threaded connectors of plastic also. These rubber struts place pressure constantly on the diaphragm pulling it toward the shoulder which closes the valve. The diaphragm member is thus fixed to the side wall of the valve housing by the elastomeric strut members. The seat of the diaphragm valve is adjustable and hence it can control the fluid pressure required to open the valve.

Description

United States Patent [191 [111 Leveen Oct. 7, 1975 [5 PROCESS FOR TREATMENT OF ASCITES AND DEVICE TO ACCOMPLISH SAME [76] Inventor: Harry H. Leveen, 800 Poly Pl.,

Brooklyn, N.Y. 11209 [22] Filed: Oct. 9, 1973 [211 App]. No.: 404,345

[52] U.S. Cl.... 128/350 V; 137/5253 [51] A61M 27/00 [58] Field of Search 128/350 V, 247, 350 R, 128/232; 137/5155, 525.3; 251/331, 342

[56] References Cited UNITED STATES PATENTS 2,638,127 5/1953 Griswold 137/5253 X 2,758,609 8/1956 Dickert et al 137/515.5 X 2,988,103 6/1961 Canvasser 137/5253 X 3,037,522 6/1962 Millan 137/5253 X 3,122,156 2/1964 Kersh 137/5253 X 3,416,562 12/1968 Freeman... 137/5253 X 3,542,026 11/1970 Bledsoe 128/350 V 3,595,240 7/1971 Mishler 128/350 X 3,769,982 11/1973 Schulte 128/350 V OTHER PUBLICATIONS The Lancet, Vol. 1 (64) 7326, p. 202-Jan. 25, 1964. Journal of Neurosurgery, 1968, Vol. XXVIIl, No. 3, pp. 283-287 Initial Experience with Hakim Valve for Ventriculovenous Shunt Robt. Gojemann.

Primary Examiner-Aldrich F. Medbery A method for the transfer of body fluid which accumulates in the peritoneal cavity into the vascular system is disclosed. This accumulation occurs most frequently with patients suffering from cirrhosis of the liver and constitutes a lethal complication. An implant device is disclosed which comprises a plastic chamber and connecting tubing, said chamber containing unique valve structure comprising a flexible diaphragm seated on a shoulder and attached to this diaphragm a connector bar which is attached at its other end to the center plate of a structure composed of several lateral silicone rubber struts which radiate out from the center plate to connect to a circular peripheral ring. The circular peripheral ring is anchored fixedly to the lateral wall of the valve housing by compression between two threaded connectors of plastic also. These rubber struts place pressure constantly on the diaphragm pulling it toward the shoulder which closes the valve. The diaphragm member is thus fixed to the side wall of the valve housing by the elastomeric strut members. The seat of the diaphragm valve is adjustable and hence it can control the fluid pressure required to open the valve.

ABSTRACT 3 Claims, 2 Drawing Figures US. Patent Oct. 7,1975

PROCESS FOR TREATNIENT OF ASCITES AND DEVICE TO ACCONIPLISH SAME BACKGROUND OF THE INVENTION Ascites is a serious medical malady characterized by an accumulation of body fluid in the peritoneal cavity. Acitic fluid as it is called accumulates most frequently with patients who have cirrhosis and unless corrected can cause death. This fluid which accumulates is rich in body building protein and unless recovered the patient suffers from wasting malnutrition.

There is no known adequate therapy at present to induce readsorption or excretion of the ascitic fluid once it is generated. Diuretic therapy and restriction of the patients salt intake can slow the accumulation of fluid but can do nothing about recovery of the fluid or removal from the body once it is formed. Under current techniques the only means employed in such cases is repeated paraceutesis to empty the peritoneal cavity of its accumulated fluid. But abviously this induces a loss of the fluid and its valuable body proteins.

A second clinical situation in which an abnormal amount of fluid collects in the body cavity is hydrocephalus. In this condition fluid accumulation occurs in a ventricle of the brain and the excess of fluid tends to compress the brain tissue.

Ideally both of these fluids should be returned to the circulating blood stream or in the case of the hydrocephalic fluid to the peritoneal cavity where it is not so great in quantity that unlike the acitic fluid it can be absorbed by the tissue. The aforesaid device and method of its use makes both fluid transfer objectives attainable and comprise the subject matter of this invention as will be described in elaborate detail below.

BRIEF DESCRIPTION OF THE INVENTION A device is described which can be permanently implanted into the human body and employed as a one way valve so that accumulated acitic fluid can be drained through a silicone rubber tubing from the peritoneal cavity into the blood stream without danger of the blood leaking back in the tube from the circulation into the peritoneum.

The valve mechanism and structure of my device has been designed to meet certain requirements. First it must be positive in action and the closure of the valve cannot depend upon flow of fluid alone because low flow rates may not be sufficient to close the valve when required. Significantly the reverse flow of even a small amount of blood from the circulation into the silicone tubing would clog the tubing since the blood would undergo thrombosis.

Second therefore the valve must normally be in a closed position and differential pressure must be employed as the actuating means to cause the valve to open and close. In practice a pressure differential of at least one or two centimeters of H 0 must exist between the venous and peritoneal fluid pressures before the valve will open and permit the peritoneal fluid to flow into the venous system. When this pressure differential disappears the valve closes.

The aforesaid mode of operation acts as a safeguard against back flow of blood and consequent thrombosis of the conduit. In addition this also slows down the delivery of fluid as the venous pressure of the receiving system rises. This prevents a sudden overloading of the circulatory system with acitic fluid. Collaterally, a normally closed valve allows the fluid accumulation to be maintained at a pressure above the venous pressure. This latter attribute is particularly important in relief of hydrocephalis where the reduction of the ventricular pressure to very low levels causes sagging of the brain tissue.

The device of the invention has a valve structure constructed of inert plastic and silicone rubber both of which materials are compatible with tissue. The device will be further described by reference to the FIG. 1 of the attached drawing of a cross sectional view of the device and FIG. 2 which is an exploded view.

In the drawing FIG. 1 it can be seen that the device comprises a plastic housing 1 which contains an inlet tube 2 coming from the peritoneum and an outlet tube 3 going into the jugular or some other large vein. Inside the plastic housing a molded lip 16 extends out from the interior of the housing wall at the end proximate to the inlet 2 and its extension forms a circular valve seat 4. A silicone rubber inverted cup structure comprises the valve disphragm 5. The valve diaphragm has a central connecting bar 6 which attaches at its opposite end to a wheel like arrangement which acts as a support means for the valve. The central connecting bar 6 attaches to a center plate 7 which has several radiating struts 8 which extend out from the central plate to a peripheral support ring 9 which fits compressively into an attachment "groove or slot 10 in the wall of the housing 1. The support ring 9 is held compressively in the groove 10 by an interior threaded connector 11 which has also an attachment shoulder 12 in the wall of the housing to attach tubing which shoulder is located distal to the fluid inlet 13 which introduces the ascites fluid into the valve chamber.

After the fluid from the peritoneum enters the fluid inlet 13 which is usually a polyethylene tubing it passes into the inlet tube 2 which emptys it into an inlet reservoir 14. When the fluid pressure in the inlet reservoir 14 builds up to a significant level it forces the upward movement of the connecting bar 6 and diaphragm 5 because of the fluid pressure exerted on the center plate 7 by the fluid collected in the fluid actuating column 17. Since the circular peripheral ring 9 is fixed in its position the upward movement of the central valve bar 6 causes the diaphragm 5 to move upward and out of its valve seat 4 and permits the fluid to flow in column 17 under the diaphragm 5 and around the same into a central collecting cavity 18 from where the fluid passes through the opening 19 which appear between the radial struts 8 of the support wheel. From there the fluid passes into the outlet reservoir and into the outlet tube and into the fluid outlet 20 which is polyethylene tube which is inserted into a large jugular vein or other large artery for passage of the fluid into the vascular system.

Continuing with the description of the operation of the device and still refering to FIGS. 1 and 2 it should be noted that the passage of fluid through the valve halts when the pressure against the valve created by the inlet fluid drops below a certain level. This causes the diaphragm 5 to return to its abutment against the valve seat 4 and once again closes the valve.

While the aforesaid disclosure will certainly suggest to those reading the same many variations in structure of the same it is applicants intention to claim the concept which is essentially defined in the following claims.

l claim as my invention:

1. I claim a method for the transfer of body fluids which accumulates in the peritoneum cavity and into the vascular system which comprises passing fluid through a connecting tube into the inlet chamber of a hollow plastic implanted valve, causing that valve to open and passing the fluid under pressure into a second reservoir from where the fluid is conducted through a second section of tubing which tubing is connected to the jugular vein of the patient.

2. A device for use in the method of claim I which comprises a plastic housing having connected on opposing surfaces, thereof an inlet tube and an outlet tube respectively said inlet tube opening on one end into the fluid from the peritoneum through the valve housing and into the outlet tube and jugular vein.

3. A device according to claim 2 wherein said pressure movable wall comprises the shape of an inverted cup and said cup is connected to a permanently attached valve support member.

Claims (3)

1. I claim a method for the transfer of body fluids which accumulates in the peritoneum cavity and into the vascular system which comprises passing fluid through a connecting tube into the inlet chamber of a hollow plastic implanted valve, causing that valve to open and passing the fluid under pressure into a second reservoir from where the fluid is conducted through a second section of tubing which tubing is connected to the jugular vein of the patient.
2. A device for use in the method of claim 1 which comprises a plastic housing having connected on opposing surfaces, thereof an inlet tube and an outlet tube respectively said inlet tube opening on one end into the peritoneum and on the other end into an inlet reservoir located within said housing, said reservoir having a pressure movable wall which comprises a flexible diaphragm which rests against a valve seat and which diaphragm moves away from said valve seat in response to pressure exerted thereon to permit flow of the body fluid from the peritoneum through the valve housing and into the outlet tube and jugular vein.
3. A device according to claim 2 wherein said pressure movable wall comprises the shape of an inverted cup and said cup is connected to a permanently attached valve support member.
US3910283A 1973-10-09 1973-10-09 Process for treatment of ascites and device to accomplish same Expired - Lifetime US3910283A (en)

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US3910283A US3910283A (en) 1973-10-09 1973-10-09 Process for treatment of ascites and device to accomplish same
DE19742444452 DE2444452C2 (en) 1973-10-09 1974-09-17
GB4206074A GB1488816A (en) 1973-10-09 1974-09-27 Fluid transfer apparatus
JP11680974A JPS558175B2 (en) 1973-10-09 1974-10-09

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JP (1) JPS558175B2 (en)
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Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4240434A (en) * 1978-10-10 1980-12-23 Newkirk John B Peritoneo-venous shunt
FR2458287A1 (en) * 1979-06-08 1981-01-02 Hakim Carlos Equipment used to treat ascites
WO1983001387A1 (en) * 1981-10-26 1983-04-28 Leveen, Harry, H. Non-clogging valved drainage system for body fluids
US4475899A (en) * 1982-09-03 1984-10-09 Becton, Dickinson And Company Shunt valve and method of use
US4553956A (en) * 1982-09-03 1985-11-19 Becton, Dickinson And Co. Shunt valve and method of use
US4610658A (en) * 1985-02-21 1986-09-09 Henry Buchwald Automated peritoneovenous shunt
US4657530A (en) * 1984-04-09 1987-04-14 Henry Buchwald Compression pump-catheter
US4991594A (en) * 1989-11-20 1991-02-12 Angelchik Jean P Method and apparatus for removing ascitic fluid from abdominal cavity
US5378228A (en) * 1991-12-16 1995-01-03 Schmalzried; Thomas P. Method and apparatus for joint fluid decompression and filtration with particulate debris collection
WO1997020584A1 (en) 1995-12-04 1997-06-12 Harry Leveen Ascites valve
US5769093A (en) * 1994-12-09 1998-06-23 Xomed Surgical Products, Inc. Method of relieving synovial fluid pressure
US5785674A (en) * 1988-10-07 1998-07-28 Mateen; Ahmed Abdul Device and method for treating glaucoma
US5813410A (en) * 1996-02-01 1998-09-29 Levin; John M. Internal body pump and systems employing same
WO2003072166A1 (en) * 2002-02-25 2003-09-04 Burnett, Daniel, R Vesicular shunt for the drainage of excess fluid
US6629950B1 (en) 1998-02-04 2003-10-07 John M. Levin Fluid delivery system
US20050096582A1 (en) * 2002-02-25 2005-05-05 Burnett Daniel R. Implantable fluid management system for the removal of excess fluid
US20050203484A1 (en) * 2004-03-12 2005-09-15 Piotr Nowak Multi-functional port
US20050212292A1 (en) * 2002-04-18 2005-09-29 Andrea Parrino Connection element and connecting device for tubes
US20060058731A1 (en) * 2004-08-18 2006-03-16 Burnett Daniel R Dialysis implant and methods of use
US20060173398A1 (en) * 2005-01-19 2006-08-03 Angelchik Jean P Method and apparatus for laparoscopic treatment of ascites
US20080289696A1 (en) * 2007-05-22 2008-11-27 Richard Paul Bushman Check valve for fluid injector
US20090065067A1 (en) * 2007-05-22 2009-03-12 Rjc Products Llc Check valve flap for fluid injector
US20090318844A1 (en) * 2003-11-03 2009-12-24 Novashunt Ag Implantable fluid management device for the removal of excess fluid
CN103405816A (en) * 2013-08-21 2013-11-27 苏州市亚新医疗用品有限公司 Anti-countercurrent block piece of drainage pack
US20140345111A1 (en) * 2005-10-11 2014-11-27 Covidien Lp Iv catheter with in-line valve and methods related thereto

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US4046479A (en) * 1976-04-23 1977-09-06 Paley Hyman W Removable locking connector for luer fittings
CA1236749A (en) * 1983-12-08 1988-05-17 Christian Sainte-Rose Three stage valve
US4681132A (en) * 1986-05-23 1987-07-21 Halkey-Roberts Corporation Check valve with preset cracking pressure
US4867740A (en) * 1988-03-24 1989-09-19 Pudenz-Schulte Medical Research Corp. Multiple-membrane flow control valve and implantable shunt system
US4861331A (en) * 1988-03-24 1989-08-29 Pudenz-Schulte Medical Research Corp. Implantable shunt system and method of assembly
JP2710355B2 (en) * 1988-09-20 1998-02-10 日本ゼオン株式会社 The medical valve device
US7326187B2 (en) * 2002-08-13 2008-02-05 Jms Co., Ltd. Fluid control device
US20080142102A1 (en) * 2006-12-18 2008-06-19 Savard Raymond T Check Valve and Pump for High Purity Fluid Handling Systems

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US2638127A (en) * 1943-09-09 1953-05-12 Clayton Manufacturing Co Molded diaphragm structure
US2758609A (en) * 1953-05-06 1956-08-14 Henry Flow Control Company Check valve
US2988103A (en) * 1957-09-30 1961-06-13 Canvasser Darwin Device for preventing back syphoning in water pipes
US3037522A (en) * 1958-04-04 1962-06-05 Otto Items Inc Check valve construction
US3122156A (en) * 1959-10-21 1964-02-25 Ronald C Kersh Flexible check valve
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US3542026A (en) * 1968-07-23 1970-11-24 Billy M Bledsoe Thoracostomy device
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US2638127A (en) * 1943-09-09 1953-05-12 Clayton Manufacturing Co Molded diaphragm structure
US2758609A (en) * 1953-05-06 1956-08-14 Henry Flow Control Company Check valve
US2988103A (en) * 1957-09-30 1961-06-13 Canvasser Darwin Device for preventing back syphoning in water pipes
US3037522A (en) * 1958-04-04 1962-06-05 Otto Items Inc Check valve construction
US3122156A (en) * 1959-10-21 1964-02-25 Ronald C Kersh Flexible check valve
US3416562A (en) * 1965-10-15 1968-12-17 Lucas Industries Ltd Heart valve
US3542026A (en) * 1968-07-23 1970-11-24 Billy M Bledsoe Thoracostomy device
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Cited By (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4240434A (en) * 1978-10-10 1980-12-23 Newkirk John B Peritoneo-venous shunt
FR2458287A1 (en) * 1979-06-08 1981-01-02 Hakim Carlos Equipment used to treat ascites
US4261341A (en) * 1979-06-08 1981-04-14 Hakim Company Limited Method and apparatus for the treatment of ascites
WO1983001387A1 (en) * 1981-10-26 1983-04-28 Leveen, Harry, H. Non-clogging valved drainage system for body fluids
US4475899A (en) * 1982-09-03 1984-10-09 Becton, Dickinson And Company Shunt valve and method of use
US4553956A (en) * 1982-09-03 1985-11-19 Becton, Dickinson And Co. Shunt valve and method of use
US4657530A (en) * 1984-04-09 1987-04-14 Henry Buchwald Compression pump-catheter
US4610658A (en) * 1985-02-21 1986-09-09 Henry Buchwald Automated peritoneovenous shunt
US5785674A (en) * 1988-10-07 1998-07-28 Mateen; Ahmed Abdul Device and method for treating glaucoma
US4991594A (en) * 1989-11-20 1991-02-12 Angelchik Jean P Method and apparatus for removing ascitic fluid from abdominal cavity
US5830172A (en) * 1991-04-11 1998-11-03 Leveen; Harry H. Ascites valve
US5378228A (en) * 1991-12-16 1995-01-03 Schmalzried; Thomas P. Method and apparatus for joint fluid decompression and filtration with particulate debris collection
US5769093A (en) * 1994-12-09 1998-06-23 Xomed Surgical Products, Inc. Method of relieving synovial fluid pressure
US5807303A (en) * 1994-12-09 1998-09-15 Xomed Surgical Products, Inc. Valve assembly and device for relieving synovial fluid pressure
WO1997020584A1 (en) 1995-12-04 1997-06-12 Harry Leveen Ascites valve
US5813410A (en) * 1996-02-01 1998-09-29 Levin; John M. Internal body pump and systems employing same
US6629950B1 (en) 1998-02-04 2003-10-07 John M. Levin Fluid delivery system
US7621886B2 (en) 2002-02-25 2009-11-24 Novashunt Ag Implantable fluid management system for the removal of excess fluid
US20050096582A1 (en) * 2002-02-25 2005-05-05 Burnett Daniel R. Implantable fluid management system for the removal of excess fluid
US8882699B2 (en) 2002-02-25 2014-11-11 Sequana Medical Ag Implantable fluid management system for the removal of excess fluid
US9421347B2 (en) 2002-02-25 2016-08-23 Sequana Medical Ag Implantable fluid management system for the removal of excess fluid
US20050273034A1 (en) * 2002-02-25 2005-12-08 Burnett Daniel R Implantable fluid management system for the removal of excess fluid
US8517973B2 (en) 2002-02-25 2013-08-27 Sequana Medical Ag Implantable fluid management system for the removal of excess fluid
WO2003072166A1 (en) * 2002-02-25 2003-09-04 Burnett, Daniel, R Vesicular shunt for the drainage of excess fluid
US20110178455A1 (en) * 2002-02-25 2011-07-21 Burnett Daniel R Implantable fluid management system for the removal of excess fluid
US7311690B2 (en) 2002-02-25 2007-12-25 Novashunt Ag Implantable fluid management system for the removal of excess fluid
US20080154173A1 (en) * 2002-02-25 2008-06-26 Novashunt Ag Vesicular shunt for the drainage of excess fluid
US7909790B2 (en) 2002-02-25 2011-03-22 Novashunt Ag Implantable fluid management system for the removal of excess fluid
US8394048B2 (en) 2002-02-25 2013-03-12 Sequana Medical Ag Vesicular shunt for the drainage of excess fluid
US20050212292A1 (en) * 2002-04-18 2005-09-29 Andrea Parrino Connection element and connecting device for tubes
US7306197B2 (en) 2002-04-18 2007-12-11 Gambro Lundia Ab Connection element and connecting device for tubes
US20090318844A1 (en) * 2003-11-03 2009-12-24 Novashunt Ag Implantable fluid management device for the removal of excess fluid
US8398577B2 (en) 2003-11-03 2013-03-19 Sequana Medical Ag Implantable fluid management device for the removal of excess fluid
US8771221B2 (en) 2003-11-03 2014-07-08 Sequana Medical Ag Implantable fluid management device for the removal of excess fluid
US20050203484A1 (en) * 2004-03-12 2005-09-15 Piotr Nowak Multi-functional port
US7699821B2 (en) * 2004-03-12 2010-04-20 Covance Laboratories Gmbh Multi-functional port
US9138523B2 (en) 2004-08-18 2015-09-22 Sequana Medical Ag Dialysis implant and methods of use
US8202248B2 (en) 2004-08-18 2012-06-19 Sequana Medical Ag Dialysis implant and methods of use
US20060058731A1 (en) * 2004-08-18 2006-03-16 Burnett Daniel R Dialysis implant and methods of use
US20060173398A1 (en) * 2005-01-19 2006-08-03 Angelchik Jean P Method and apparatus for laparoscopic treatment of ascites
US20140345111A1 (en) * 2005-10-11 2014-11-27 Covidien Lp Iv catheter with in-line valve and methods related thereto
US8714200B2 (en) 2007-05-22 2014-05-06 Rjc Products, Llc Check valve flap for fluid injector
US8752579B2 (en) 2007-05-22 2014-06-17 Rjc Products Llc Check valve for fluid injector
US8256464B2 (en) * 2007-05-22 2012-09-04 Rjc Products Llc Check valve flap for fluid injector
US20080289696A1 (en) * 2007-05-22 2008-11-27 Richard Paul Bushman Check valve for fluid injector
US20090065067A1 (en) * 2007-05-22 2009-03-12 Rjc Products Llc Check valve flap for fluid injector
CN103405816A (en) * 2013-08-21 2013-11-27 苏州市亚新医疗用品有限公司 Anti-countercurrent block piece of drainage pack

Also Published As

Publication number Publication date Type
DE2444452A1 (en) 1975-05-28 application
GB1488816A (en) 1977-10-12 application
JP1017438C (en) grant
JPS50111892A (en) 1975-09-02 application
DE2444452C2 (en) 1985-07-04 grant
JPS558175B2 (en) 1980-03-03 grant

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