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Selectively detachable apparatus

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Publication number
US3907505A
US3907505A US36515873A US3907505A US 3907505 A US3907505 A US 3907505A US 36515873 A US36515873 A US 36515873A US 3907505 A US3907505 A US 3907505A
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Prior art keywords
member
frangible
apparatus
rib
fig
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Glenn Lee Beall
Fred K White
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NUNC INCORPORATED A DE CORP
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Bayer Corp
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates

Abstract

Organoplastic apparatus which is capable of being frangibly separated into a plurality of individual segments. The separable segments are attached to one another by a relatively thin narrow frangible member which is integral with and extends longitudinally between the separable segments. This frangible member is reinforced by at least one integral rib member which extends transversely thereof between the separable segments.

Description

United States Patent Real] et al.

[4 1 Sept. 23, 1975 SELECTIVELY DETACHABLE APPARATUS lnventors: Glenn Lee Beall, Gurnee; Fred K.

White, Glen Ellyn, both of Ill.

Miles Laboratories, Inc., Elkhart, Ind.

Filed: May 30, 1973 Appl. No.: 365,158

Assignee:

US. Cl. 23/259; 23/292; 220/234 Int. Cl. BOIL 3/00 Field of Search 23/292, 259; 220/234,

References Cited UNITED STATES PATENTS 5/l965 Kuhlman 220/234 X Smith ct al 220/234 Pollack et al. 220/234 X Primary Examiner-Morris O. Wolk Assistant Exuminer-Michael S. Marcus Attorney, Agent, or Firm-Louis E. Davidson [57] ABSTRACT Organoplastic apparatus which is capable of being frangibly separated into a plurality of individual segments. The separable segments are attached to one another by a relatively thin narrow frangible member which is integral with and extends longitudinally be tween the separable segmentspThis frangible member is reinforced by at least one integral rib member which extends transversely thereof between the separable segments.

5 Claims, 6 Drawing Figures US Patent Sept. 23,1975 Sheet 1 of2 3,907,505

f2? 29 28 E T E 7/ ;f/// 3o 2? 30 F 28 FIG. 3 FIG. 4

44 4o 39 as 260 400 H FIG. 5

SELECTIVELY DETACHABLE APPARATUS BACKGROUND ANDFRIOR ART Organoplastic laboratory apparatus having a plurality of chambers or test wells is well-known. Usually such apparatus is used in the formin which produced, and the user selects an apparatus-having the desired final number of chambers or test wells. Thelmanufacturer can make available several forms of a particular type of apparatus each form having a different numberof chambers or test wells. This increases the unit manufacturing cost and still limits the user to the particular apparatus configurations supplied by the manufacturers. a

It has been suggested in the segments each having a lesser number ofchambers than in the initial overall apparatus. It was previously suggested that the spacing between adjacent chambers could be scored,as with a glass cutter, the chambersto be separated by breaking the apparatus along the scored line. This technique is expensive from a manu facturin g standpoint. Another prior art suggestion was to form the apparatus with a thin frangible member between adjacent chambers, such member to be broken by bending. This technique had the disadvantage of requiring severalbending movements in order to break the frangible member.

There is thus a need for organoplastic apparatus which can be inexpensively manufactured and which, with a minimum of effort, can be separated as desired into segments. i

SUMMARY OF THE INVENTION In accordance with the present invention unitary organoplastic apparatus is provided which is capable of being frangibly separated into a plurality of individual segments wherein the separable segments are attached to one another by a relatively thin narrow frangible member which is integral with and extends longitudinally between such separable segments, each thin frangible member being reinforced by at least one integral rib member which extends transversely thereof be tween the separable segments.

DESCRIPTION OF THE DRAWINGS FIG. 1 is a perspective view of one embodiment of the present invention;

FIG. 2 is an enlarged vertical cross-section view taken along Line 22 of FIG. 1;

FIG. 3 is an enlarged vertical cross-section view taken along Line 3-3 of FIG. 1;

FIG. 4 is a vertical cross-section view taken along Line 4-4 of FIG. 2;

FIG/ 5 is a plan view of the underside of another embodiment of the present invention; and

FIG. 6 is an enlarged partial lower perspective view of the underside shown in FIG. 5.

DESCRIPTION OF THE INVENTION Referring to FIGS. 1 and 2, the illustrated embodiment of the apparatus 10 of the present invention comprises an elongated rectangular base portion 12 having a planar top surface 14, a planar bottom surface 15 and a plurality of walls, such as 16 and 18, extending upward from said base portion to form a plurality of spaced rectangular chambers or test wells. Walls 16 prior art that a'multiplechamber apparatus be provided which is separable into form chamber 17 and walls 18 form adjacent chamber 19. In a similar fashion chambers 20, 21, 22, 23, 24 and 25 are formed on said base portion. Formed in the bottom surface 15 is alongitudinal groove 26 which separates the base portion 12 into two elongated segments 27 and 28 which are attached to each other by an elongated thin narrow member 29 which is integral with and extends longitudinally between such segments. This thin member 29 is reinforced near one end by an integral rib member 30 which extends transversely thereof between segments 27 and 28. The member 29 is reinforced near its other end with a similar integral rib member 31 which is shown in FIG. 2.

Apparatus 10 is easily and inexpensively formed as a unitary structure from frangible organoplastic materials, such as polystyrene, polyacrylate, polymethacryate, acrylonitrile-styrene copolymers, nitrile acrylonitrile-styrene copolymers, polyphenyleneoxide, phenoxy resins and the like. These materials are also desirably transparent.

The apparatus illustrated in FIG. 1 has eight chambers or test wells. If it is desired to employ only four chambers, segment27 which has the desired number of chambers can be detached from segment 28 by breaking the apparatus along thin narrow frangible member 29. when forces are applied to the apparatus, as shown by the arrows labeled F" in FIG. 4, which tend to bend the two segments 27 and 28 about a hinge formed member 29, the rib member 30 prevents such bending and, forces member 29 to conveniently break due to tensile stress. If rib member 30 were not present. member 29 wouldjust bend and would require several backand-forth bending movements before member 29 would break. The presence of rib member 30 thus enables the two segments to be separated easier than if it were not present. In view of the extended length of thin narrow frangible member 29, it is desirable to have additional rib members, such as rib member 31, disposed along its length to assist in preventing appreciable bending of member 29.

If it is desired to have the apparatus separable into still smaller segments, the structure of the embodiment shown in FIG. 5 can be employed. Elements in FIG. 5 corresponding to similar elements in FIGS. 1-4 have the same numbers with the suffix a. As shown in FIG.

5, the bottom surface 15a of base member 12a is formed with transverse grooves 32, 33, 34 and 47 as well as with longitudinal groove 26a. The transverse grooves enable the segments to be broken off along the corresponding thin narrow frangible members 35, 36, 37 and 46. Rib members 38 and 41 reinforce the frangible member 35, rib members 39 and 42 reinforce the frangible member 36, rib members and 43 reinforce the frangible member 37 and rib members 44 and 45 reinforce the frangible member 46 in the same way that rib members 3011 and 31a reinforce the frangible member 29a. Rib members 38, 39, 40, 41, 42, 43, 44 and 45 function as described above to prevent bending of the thin narrow frangible members reinforced thereby during breaking. There must be at least one rib member associated with each thin narrow frangible member that is to be broken.

Further details of the relationship between the grooves and the rib members of FIG. 5 are shown in FIG. 6. This is an enlarged partial lower perspective view of the underside shown in FIG. 5. The various elements corresponding to those of FIG. 5 are numbered identically.

The frangible member, such as element 29, should have a thickness of about twenty percent of the thickness of the adjacent members, such as element segments 27 and 28. The width of element 29, for example, between segments 27 and 28 should be about equal to its thickness. The rib member, such as rib 30, should have'a width about equal to that of the thickness of the frangible member 29 and a depth at least about equal to the width of. the rib member.

The;thin frangible member shown as element 29 in FIG. 4 has a thickness, measured in the dimension of from about 0.0l to about 0.015 in. and a width from segment 21 to segment 28 of from about 0.0] to about 0.015 in. when segments 27 and 28 have a thickness of about0.05 in. The rib members represented by element 30in FlG. 4 and element 301: in FIG. 5 have a width, measured in the dimension W", of about 0.015 in. and a depth distance, measured in the dimension Y, of from about 0.015 to about 0.045 in.

The above-described apparatus employed a total of eight chambers or test wells. It is understood that apparatus of the present invention can employ more or less than eight chambers or test wells.

The apparatus of the present invention is useful in a well-known manner in medical laboratory practice as well as in biological research to grow various cells or tissues in particular media.

What is claimed is:

1. An organoplastic device having a plurality of test wells for receiving material, thetest wells being formed on a generally planar base, the base having a top and a bottom surface, and having at least one straight groove extending edge to edge in the bottom surface and extending toward the upper surface, each said groove providing a locus for frangible separation of the formed test wells, the residue above each said groove constituting a frangible member for the said separation, each frangible member being reinforced by at least one solid rib member transverse to the respective groove within the groove and dependently contacting the upper portion of the groove, the total thickness of said rib member and said frangible member being lessthan the thickness of said generally planar base.

2. Apparatus according to claim 1 wherein the organoplastic material is selected from the class consisting of polystyrene, polyacrylate, polymethacrylate, acrylonitrile-styrene copolymers, nitrile-acrylonitrilestyrene copolymers,; polyphenyleneoxide and phenoxy resins. v

3. Apparatus according to claim 1 wherein the frangible member has a thickness of about 20 percent of the thickness of the generally planar base and a width about equal to its thickness and wherein the integral rib member has a width about equal to the thickness of the frangible member and a depth at least about equal to the width of said rib member.

4. Apparatus according to claim '1 wherein the frangible member has a thickness of from about 0.01 to about 0.015 in. and a width of from about 0.01 to about 0.015

5. Apparatus according to claim 1 wherein the reinforcing rib member has a width of about 0.015 in. and

a depth of from about 0.015 to about 0.045 in.

* l l =l

Claims (5)

1. AN ORGANOPLASTIC DEVICE HAVING A PLURALITY OF TEST WELLS FOR RECEIVING MATERIAL, THE TEST WELLS BEING FORMED ON A GENERALLY PLANNAR BASE, THE BASE HAVING A TOP AND A BOTTOM SURFACE, AND HAVING AT LEAST ONE STRAIGHT GROOVE EXTENDING EDGE TO EDGE IN THE BOTTOM SURFACE AND EXTENDING TOWARD THE UPPER SURFACE, EACH SAID GROOVE PROVIDING A LOCUS FOR FRANGIBLE SEPARATION OF THE FORMED TEST WELLS, THE RESIDUE ABOVE EACH SAID GROOVE CONSTITUTING A FRANGIBLE MEMBER FOR THE SAID SEPARATION EACH FRANGIBLE MEMBER BEING REINFORCED BY AT LEAST ONE SOLID RIB MEMBER TRANVERSE TO THE RESPECTIVE GROOVE WITHIN THE GROOVE AND DEPENDENTLY CONTACTING THE UPPER PORTION OF THE GROOVE, THE TOTAL THICKNESS OF SAID RIB MEMBER AND SAID FRANGIBLE MEMBER BEING LESS THAN THE THICKNESS OF SAID GENERALLY PLANAR BASE.
2. Apparatus according to claim 1 wherein the organoplastic material is selected from the class consisting of polystyrene, polyacrylate, polymethacrylate, acrylonitrile-styrene copolymers, nitrile-acrylonitrile-styrene copolymers, polyphenyleneoxide and phenoxy resins.
3. Apparatus according to claim 1 wherein the frangible member has a thickness of about 20 percent of the thickness of the generally planar base and a width about equal to its thickness and wherein the integral rib member has a width about equal to the thickness of the frangible member and a depth at least about equal to the width of said rib member.
4. Apparatus according to claim 1 wherein the frangible member has a thickness of from about 0.01 to about 0.015 in. and a width of from about 0.01 to about 0.015 in.
5. Apparatus according to claim 1 wherein the reinforcing rib member has a width of about 0.015 in. and a depth of from about 0.015 to about 0.045 in.
US3907505A 1973-05-30 1973-05-30 Selectively detachable apparatus Expired - Lifetime US3907505A (en)

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US3907505A US3907505A (en) 1973-05-30 1973-05-30 Selectively detachable apparatus
GB1844974A GB1432114A (en) 1973-05-30 1974-04-26 Selectively detachable apparatus
JP5890674A JPS5022694A (en) 1973-05-30 1974-05-27

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Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4038149A (en) * 1975-12-31 1977-07-26 Linbro Scientific, Inc. Laboratory trays with lockable covers
US4154795A (en) * 1976-07-23 1979-05-15 Dynatech Holdings Limited Microtest plates
US4215092A (en) * 1976-04-08 1980-07-29 Osmo A. Suovaniemi Apparatus for liquid portioning and liquid transferring
US4392389A (en) * 1980-10-07 1983-07-12 Dragerwerk Aktiengesellschaft Sampling tube having closing caps
US4472357A (en) * 1981-11-18 1984-09-18 Medical Laboratory Automation, Inc. Blood bank cuvette cassette and label therefor
US4495289A (en) * 1981-03-17 1985-01-22 Data Packaging Corporation Tissue culture cluster dish
US4829006A (en) * 1988-02-01 1989-05-09 Difco Laboratories Centrifugation vial and cluster tray
US4970053A (en) * 1986-07-11 1990-11-13 Beckman Instruments, Inc. Reagent cartridge
DE9015317U1 (en) * 1990-11-07 1991-03-14 Panitz, Norbert, Dr., 6500 Mainz, De
US5075082A (en) * 1986-07-11 1991-12-24 Beckman Instruments, Inc. Reagent cartridge
DE9203583U1 (en) * 1992-03-17 1992-05-07 Alcan Deutschland Gmbh, 3400 Goettingen, De
USRE34133E (en) * 1976-07-23 1992-11-24 Dynatech Holdings, Ltd. Microtest plates
US5208161A (en) * 1987-08-27 1993-05-04 Polyfiltronics N.A., Inc. Filter units
US5470536A (en) * 1992-11-11 1995-11-28 Labsystems Oy Cuvette matrix
US5514343A (en) * 1994-06-22 1996-05-07 Nunc, As Microtitration system
GB2288233B (en) * 1994-04-06 1998-10-28 Akzo Nobel Nv Microtitration plate
FR2780903A1 (en) * 1998-07-13 2000-01-14 Central Labo Europ destinee plate including microtiter having a plurality of wells for receiving samples of a biological fluid
WO2000029110A1 (en) * 1998-11-18 2000-05-25 Pepscan Systems B.V. Matrix plate, method and apparatus for sample analysis
US6096562A (en) * 1997-10-27 2000-08-01 Nalge Nunc International Corporation Multi-slide assembly including slide, frame and strip cap, and methods thereof
EP1053790A3 (en) * 1999-05-20 2001-01-31 Advanced Biotechnologies Limited Improved multi-well plates.
DE20101080U1 (en) * 2001-01-20 2002-06-06 Evotec Biosystems Ag inspection device
DE10203940A1 (en) * 2002-02-01 2003-08-21 Fraunhofer Ges Forschung Plate for use in cryogenic storage of biological specimens has wells, into which specimens are placed, fits into cover in same way as drawer of matchbox, and is held in position by e.g. studs and recesses
EP1348485A1 (en) * 2002-02-28 2003-10-01 The Automation Partnership (Cambridge) Limited Sample handling system and method
US20050061227A1 (en) * 2003-09-18 2005-03-24 Troy Ostreng Molded plastic gangway
EP1754538A2 (en) 2005-08-02 2007-02-21 Advanced Biotechnologies Limited Two-part microwell plates and methods of fabricating same
US20070184551A1 (en) * 1999-02-09 2007-08-09 Jean-Pascal Viola Crystallization Methods for laboratory cap and well
DE102010008036A1 (en) * 2010-02-05 2011-08-11 Eppendorf AG, 22339 microtiter plate
US20110286897A1 (en) * 2010-02-05 2011-11-24 Eppendorf Ag Microtiter plate
GB2494860A (en) * 2011-09-07 2013-03-27 Abgene Ltd An array of PCR wells and an array of caps for such a well array
US20130237443A1 (en) * 2012-03-06 2013-09-12 Scienion Ag Spotting plate and process for its production
US20150056562A1 (en) * 2013-08-22 2015-02-26 Lydia KLEFFMANN Candle magazine
DE19933458B4 (en) * 1999-07-15 2015-08-20 Eppendorf Ag Equipment and systems for handling liquid samples

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JPS52105475U (en) * 1976-02-06 1977-08-11
GB2023489B (en) * 1978-06-21 1982-05-06 Lkb Produkter Ab Ejecting from a mould
US4664993A (en) * 1981-08-24 1987-05-12 Polaroid Corporation Laminar batteries and methods of making the same
DE19807177A1 (en) * 1998-02-20 1999-09-16 Scil Animal Care Company Gmbh analysis system

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US3184054A (en) * 1962-07-13 1965-05-18 Rca Corp Package
US3520439A (en) * 1967-10-04 1970-07-14 Hindmarch Smith Plastics Ltd Container
US3660934A (en) * 1970-05-11 1972-05-09 Vaughns Of Arizona Molded expandable nursery tray

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US3520439A (en) * 1967-10-04 1970-07-14 Hindmarch Smith Plastics Ltd Container
US3660934A (en) * 1970-05-11 1972-05-09 Vaughns Of Arizona Molded expandable nursery tray

Cited By (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4038149A (en) * 1975-12-31 1977-07-26 Linbro Scientific, Inc. Laboratory trays with lockable covers
US4215092A (en) * 1976-04-08 1980-07-29 Osmo A. Suovaniemi Apparatus for liquid portioning and liquid transferring
USRE34133E (en) * 1976-07-23 1992-11-24 Dynatech Holdings, Ltd. Microtest plates
US4154795A (en) * 1976-07-23 1979-05-15 Dynatech Holdings Limited Microtest plates
US4392389A (en) * 1980-10-07 1983-07-12 Dragerwerk Aktiengesellschaft Sampling tube having closing caps
US4495289A (en) * 1981-03-17 1985-01-22 Data Packaging Corporation Tissue culture cluster dish
US4472357A (en) * 1981-11-18 1984-09-18 Medical Laboratory Automation, Inc. Blood bank cuvette cassette and label therefor
US4970053A (en) * 1986-07-11 1990-11-13 Beckman Instruments, Inc. Reagent cartridge
US5075082A (en) * 1986-07-11 1991-12-24 Beckman Instruments, Inc. Reagent cartridge
US5208161A (en) * 1987-08-27 1993-05-04 Polyfiltronics N.A., Inc. Filter units
US4829006A (en) * 1988-02-01 1989-05-09 Difco Laboratories Centrifugation vial and cluster tray
DE9015317U1 (en) * 1990-11-07 1991-03-14 Panitz, Norbert, Dr., 6500 Mainz, De
DE9203583U1 (en) * 1992-03-17 1992-05-07 Alcan Deutschland Gmbh, 3400 Goettingen, De
US5470536A (en) * 1992-11-11 1995-11-28 Labsystems Oy Cuvette matrix
GB2288233B (en) * 1994-04-06 1998-10-28 Akzo Nobel Nv Microtitration plate
US5514343A (en) * 1994-06-22 1996-05-07 Nunc, As Microtitration system
US6383820B1 (en) 1997-10-27 2002-05-07 Nalge Nunc International Corporation Multi-slide assembly including slide, frame and strip cap, and methods thereof
US6096562A (en) * 1997-10-27 2000-08-01 Nalge Nunc International Corporation Multi-slide assembly including slide, frame and strip cap, and methods thereof
US6803239B2 (en) 1997-10-27 2004-10-12 Nalge Nunc International Corporation Multi-slide assembly including slide, frame and strip cap, and methods thereof
US6540965B2 (en) 1998-07-13 2003-04-01 Central Labo Europe S.A.R.L. Biological analysis and apparatus for storage of biological samples
WO2000002661A1 (en) * 1998-07-13 2000-01-20 Central Labo Europe (S.A.R.L.) Plate for biological analysis and preservation of biological samples
FR2780903A1 (en) * 1998-07-13 2000-01-14 Central Labo Europ destinee plate including microtiter having a plurality of wells for receiving samples of a biological fluid
WO2000029110A1 (en) * 1998-11-18 2000-05-25 Pepscan Systems B.V. Matrix plate, method and apparatus for sample analysis
NL1010588C2 (en) * 1998-11-18 2000-05-31 Pepscan Systems Bv Matrix plate, method and apparatus for analysis of samples.
US20070184551A1 (en) * 1999-02-09 2007-08-09 Jean-Pascal Viola Crystallization Methods for laboratory cap and well
US7316805B1 (en) 1999-02-09 2008-01-08 Qiagen, Inc. Laboratory cap and well for hanging-drop crystallization methods
US6558631B1 (en) 1999-05-20 2003-05-06 Advanced Biotechnologies Ltd. Multi-well plates
EP1053790A3 (en) * 1999-05-20 2001-01-31 Advanced Biotechnologies Limited Improved multi-well plates.
GB2350189B (en) * 1999-05-20 2001-12-19 Advanced Biotech Ltd Improved multi-well plates
DE19933458B4 (en) * 1999-07-15 2015-08-20 Eppendorf Ag Equipment and systems for handling liquid samples
DE20101080U1 (en) * 2001-01-20 2002-06-06 Evotec Biosystems Ag inspection device
DE10203940B4 (en) * 2002-02-01 2006-06-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Kryoprobenträger modular cryo-storage
DE10203940A1 (en) * 2002-02-01 2003-08-21 Fraunhofer Ges Forschung Plate for use in cryogenic storage of biological specimens has wells, into which specimens are placed, fits into cover in same way as drawer of matchbox, and is held in position by e.g. studs and recesses
EP1348485A1 (en) * 2002-02-28 2003-10-01 The Automation Partnership (Cambridge) Limited Sample handling system and method
US6912966B2 (en) 2003-09-18 2005-07-05 E-Z Dock, Inc. Molded plastic gangway
US20050061227A1 (en) * 2003-09-18 2005-03-24 Troy Ostreng Molded plastic gangway
EP1754538A2 (en) 2005-08-02 2007-02-21 Advanced Biotechnologies Limited Two-part microwell plates and methods of fabricating same
US20110286897A1 (en) * 2010-02-05 2011-11-24 Eppendorf Ag Microtiter plate
DE102010008036A1 (en) * 2010-02-05 2011-08-11 Eppendorf AG, 22339 microtiter plate
GB2494860B (en) * 2011-09-07 2013-10-16 Abgene Ltd Improved plate
GB2494860A (en) * 2011-09-07 2013-03-27 Abgene Ltd An array of PCR wells and an array of caps for such a well array
US20130237443A1 (en) * 2012-03-06 2013-09-12 Scienion Ag Spotting plate and process for its production
US20150056562A1 (en) * 2013-08-22 2015-02-26 Lydia KLEFFMANN Candle magazine
US20160201899A1 (en) * 2013-08-22 2016-07-14 Cup Candle Gmbh Candle cartridge

Also Published As

Publication number Publication date Type
JPS5022694A (en) 1975-03-11 application
GB1432114A (en) 1976-04-14 application

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AS Assignment

Owner name: NUNC, INCORPORATED, 2373 TELLER ROAD, NEWBURY PARK

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:MILES LABORATORIES, INC., A DE CORP.;REEL/FRAME:004940/0607

Effective date: 19880616

Owner name: NUNC, INCORPORATED, A DE CORP.,CALIFORNIA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:MILES LABORATORIES, INC., A DE CORP.;REEL/FRAME:004940/0607

Effective date: 19880616