US3906959A - Liquid leak stop for an implantable heart pacer - Google Patents

Liquid leak stop for an implantable heart pacer Download PDF

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US3906959A
US3906959A US442536A US44253674A US3906959A US 3906959 A US3906959 A US 3906959A US 442536 A US442536 A US 442536A US 44253674 A US44253674 A US 44253674A US 3906959 A US3906959 A US 3906959A
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heart
pacer
pulse generator
shield
patient
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US442536A
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Robert L Cannon
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American Optical Corp
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American Optical Corp
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Priority to US442536A priority Critical patent/US3906959A/en
Priority to DE2505029A priority patent/DE2505029C2/en
Priority to JP50016996A priority patent/JPS50114892A/ja
Priority to GB6384/75A priority patent/GB1498529A/en
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Publication of US3906959A publication Critical patent/US3906959A/en
Assigned to COOK PACEMAKER CORPORATION reassignment COOK PACEMAKER CORPORATION LICENSE (SEE DOCUMENT FOR DETAILS). EFFECTIVE 03/27/81 Assignors: ATLANTIC RICHFIELD COMPANY
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372Arrangements in connection with the implantation of stimulators
    • A61N1/375Constructional arrangements, e.g. casings
    • A61N1/3752Details of casing-lead connections
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01BCABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
    • H01B17/00Insulators or insulating bodies characterised by their form
    • H01B17/26Lead-in insulators; Lead-through insulators
    • H01B17/30Sealing

Definitions

  • the present invention relates generally to implantable heart pacers, and more specifically relates to means for preventing bodily fluids from leaking into the paccrs electronic circuitry.
  • Heart stimulating devices have been known for some time. Several years ago, heart stimulating devices which provide stimulation at a fixed or constant rate were developed. They had disadvantages since they created competitive problems with a patients natural spontaneous heartbeat. More recently, heart stimulating devices which supply stimulation to the heart only when required have been developed, and these pacers solved the competition problem. And even more recently, heart pacers that supply stimulation only when required and in proper sequence to two chambers of the heart, the atrium and the ventricle, have been developed. The present invention is adaptable for use with all of these pacers and others.
  • An implanted pacer provides stimulation to the heart of a patient through electrical conductors contained within a catheter, the conductors connecting the pacer pulse generator output to electrodes in electrical contact with the heart. Because the size and shape of the human body varies from person to person, and for other medical and commercial reasons, catheters are not permanently sealed to the pacer. Thus, there exists a mechanical connection or fitting between the catheter assembly and the pacer itself and this connection is subject to hostile body environment. It is through this connection that fluid leakage may occur. These unwanted fluids can cause a pacers electronic circuitry to short-circuit, and can cause other metal parts within a pacer to corrode. This situation leads to reduced pacer performance, if not complete failure and is a severe problem.
  • a malfunctioning pacer is usually removed by surgical procedure and replaced. It is unfortunate that a pacer which would otherwise have additional years of operational life must be removed because of a liquid leak. The unfortunate patient is subjected to surgical procedures which he may otherwise not have to endure so frequently. This has been a shortcoming of prior art pacers over the years.
  • Applicants present invention provides a solution to this problem of bodily fluid pacer leakage.
  • the solution is commercially embodied in the Mark II pacer of the American Optical Corporation, which has proven to be capable of virtually completely eliminating this leakage problem.
  • an implantable heart pacer which is constructed in a manner to segregate the electronics portion from the remaining portions of the pacer, and where all pacer components and conductors are potted in an epoxy insulation, there are two extending conductors connecting this electronics portion or package to the electrode throat or connector.
  • the electrode throat is adapted to be connected to a catheter for conductive connection to the patients heart. Leakage from the body of the patient into the throat and along the extending conductors is halted by separate shields or partitions through which each conductor passes, to which each conductor is soldered, and with which the epoxy insulation is bonded.
  • advantages of the present invention include elimination of frequent surgical procedures to replace inoperative pacers due to leakage failure.
  • FIG. 1 depicts an illustrative embodiment of the present invention
  • FIG. 2 depicts certain details of the illustrative embodiment of FIG. 1;
  • FIG. 3 depicts an alternative embodiment of the detail of FIG. 2.
  • FIG. 4 depicts an interconnection of the functional blocks of the illustrative embodiment of FIG. 1 and their connection to the heart of a patient.
  • implantable pacer 10 contains batteries 12, 13, 14, 15, and 16 connected in a manner to provide appropriate supply voltage on conductors l7 and 18 to electronics 19.
  • the batteries are depicted as being connected in parallel, but a series connection is likewise suitable and generally used.
  • Reference numeral l9 depicts an enclosure for the electronics portion of pacer l0.
  • Semi-conductors and other components interconnected thereto are contained within enclosure 19 which is intended to act as an RF shield and as a protective device against other harmful physical effects.
  • US. Pat. Nos. 3,528,428 and 3,595,242 describe electronic circuitry which may be employed within enclosure 19.
  • Conductors 20 and 21 are connected between electronics 19 and catheter-throat or electrode-connector-reeeptacle 11. The catheter leading to the heart is not shown in FIG. 1. Conductors 20 and 21 extend input signals from the patients heart to the electronics and likewise provide output stimulation from the electronics to the patients heart. Connector aperture 11 is designed to receive electrodes for connection to the patients heart. Shields or partitions 22 and 23 encompass conductors 21 and 20 respectively. Epoxy insulation 122 is shown in proximity with shields 23 and 22 only, for purposes of clarity of illustration; but it is understood that the insulation extends throughout the interior of pacer 10.
  • shield 23 is shown in an elevational view in more detail.
  • Shield 23 contains hole 25 which is plated-through.
  • Reference numeral 24 represents metallic deposition on both sides of shield 23 as well as on the inside surface of hole 25.
  • Conductor is inserted through hole and is soldered to metallic deposition 24.
  • Composition of shield 23 is selected to have certain properties including high and substantial adhesion or bonding with insulation I22.
  • insulation 122 is constructed from epoxy, and material for shield 23 can be selected from the same generic class of synthetics. In a preferred embodiment it is constructed from materials from which ordinary printed circuit boards are constructed, e.g., glass epoxy laminate.
  • FIG. 1 and FIG. 2 shows that bodily fluids (not shown) which may tend to leak into aperture 11 and which are transported along conductors 20 and 21 are abruptly halted in their movement by shields 23 and 22.
  • the extremely tight bonding between surrounding epoxy insulation 122 and the shields prevents the bodily fluids from moving beyond the placement or location of the shields themselves.
  • FIG. 3 depicts an alternative embodiment of the present invention.
  • Reference numeral 26 depicts a shield having two apertures 28 and 29. These apertures are conductively connected together by metallic deposit 27 which likewise is plated through each of the apertures.
  • metallic deposit 27 which likewise is plated through each of the apertures.
  • two shields are needed as before.
  • One shield 26 is needed for conductor 20 and the other shield 26 is needed for conductor 21.
  • This alternative embodiment facilitates manufacturing assembly since each conductor need not be inserted through a hole and soldered thereto but merely has to be brought up to the hole and soldered to the metallic deposit. Other separate conductors are extended from the remaining apertures by soldering to the metallic deposits on the remaining apertures.
  • FIG. 4 depicts pacer l0 and functional blocks included therein.
  • Power supply or batteries 44 supplies power to heartbeat detector 43 and pulse generator 42.
  • Conductors 20 and 21 are extended to heart 41 as described earlier.
  • Pulse generator 42 supplies stimulation impulses on conductors 45 and 46 which are connected to conductors 20 and 21 respectively.
  • conductors 47 and 48 which are connected to conductors 45 and 46 respectively, are extended back to the input of heartbeat detector 43 thereby providing means for sensing beating action of heart 41.
  • Output of heartbeat detector 43 feeds input of pulse generator 42 and thus heartbeat detector 43 controls operation of pulse generator 42.
  • Shields 23 and 22 are shown in connection with conductors 20 and 21 as noted earlier.
  • An implantable heart pacer for providing stimulation to the heart of a patient.
  • said pacer comprising terminal means for connection to said patients heart, pulse generator means for providing stimulation impulses.
  • means comprising two conductor leads for extending said impulses to said terminal means, means for detecting the beating action of said patients heart.
  • said incompressible liquid leak stop means constructed from at least glass-epoxy laminate adheringly connected to said extending means and bonded with said insulation for preventing flow of liquid from said terminal means towards said pulse generator means along said extending means, and wherein said incompressible liquid leak stop means is formed as two separate shields with an aperture through each of said shields, the inside shield surface and adjacent shield periphery of each of said apertures having depos ited thereon a conductive metal, each of said apertures being adapted to receive one of said leads, and means for sealing said conductive metal around each of said leads in a manner to prevent said flow of liquid through each of said apertures, the remaining surface of each of said shields being bonded to said insulation whereby said flow of liquid is prevented from flowing around each of said shield
  • An implantable heart pacer for providing stimulation to the heart of a patient, said pacer comprising terminal means for connection to said patient's heart, pulse generator means for providing stimulation impulses.
  • means comprising at least one conductor lead for extending said impulses to said terminal means, means for detecting the beating action of said patients heart, means responsive to operation of said detecting means for controlling said pulse generator means, battery means for energizing said pulse generator means and said detecting means, epoxy insulation encapsulating said extending means, said battery ,means, said detecting means, said controlling means, and said pulse generator means, and incompressible liquid leak stop means comprising at least one incompressible shield with an aperture therethrough, conductive metal, the inside shield surface and adjacent shield periphery of said aperture having adheringly deposited thereon said conductive metal.
  • said aperture being adapted to receive said lead, and means for sealing said conductive metal around said lead in a manner to prevent flow of liquid from said terminal means towards said pulse generator means through said aperture, the remaining surface of said shield being bonded to said insulation whereby said flow of liquid is prevented from flowing around said shield.

Abstract

A liquid leak stop for an implantable heart pacer. There is disclosed an implantable heart pacer for providing stimulation to the heart of a patient. The pacer includes a heartbeat detector, a pulse generator, batteries for powering or energizing the electronics, and electrodes or terminals for connection to the heart. Human body fluids tend to leak into the electrode throat or connector receptacle of the implantable pacer. This leakage can cause pacer malfunction. There are disclosed means for halting this leakage along conductors connecting the pacerexternal electrodes and the pacer-internal electronics.

Description

UnitedStates Patent 11 1 Cannon Sept. 23, 1975 LIQUID LEAK STOP FOR AN IMPLANTABLE HEART PACER [75] Inventor: Robert L. Cannon, Waltham, Mass.
[73] Assignee: American Optical Corporation,
Southbridge, Mass.
22 Filed: Feb. 14, 1974 21 Appl. No.: 442,536
[52] US. Cl 128/419 P; 174/52 PE [51] Int. CI. A61N 1/36 [58] Field of Search 128/419 C, 419 E, 419 P,
128/419 R, l R; 174/22 R, 23 R, 52 PE, 65 R; 339/214 R; 3/1
[56] References Cited UNITED STATES PATENTS 3,478,746 11/1969 Greatbatch 128/419 P 3,735,766 5/1973 Bowers et a1 128/419 P FOREIGN PATENTS OR APPLICATIONS 730,606 5/1955 United Kingdom 174/52 PE Primary Examiner-William E. Kamm Attorney, Agent, or FirmJoel Wall; William C. Nealon; H. R. Berkenstock, Jr.
[57] ABSTRACT 3 Claims, 4 Drawing Figures ELECTRONICS US Patent Sept. 23,1975 3,906,959
WMQ 22 ELECTRON/CS K '\,la A y J l l2 l3 14 I5 /5 POWER SUPPLY 42 20 4| 43 l 23 f Q J/[45 HEARTBEAT PULSE If DETECTOR GENERATOR H L J i.- Z2. 4a 46 LIQUID LEAK STOP FOR AN IMPLANTABLE HEART PACER BACKGROUND OF THE INVENTION l. Field of the Invention The present invention relates generally to implantable heart pacers, and more specifically relates to means for preventing bodily fluids from leaking into the paccrs electronic circuitry.
2. Description of Prior Art Heart stimulating devices have been known for some time. Several years ago, heart stimulating devices which provide stimulation at a fixed or constant rate were developed. They had disadvantages since they created competitive problems with a patients natural spontaneous heartbeat. More recently, heart stimulating devices which supply stimulation to the heart only when required have been developed, and these pacers solved the competition problem. And even more recently, heart pacers that supply stimulation only when required and in proper sequence to two chambers of the heart, the atrium and the ventricle, have been developed. The present invention is adaptable for use with all of these pacers and others.
An implanted pacer provides stimulation to the heart of a patient through electrical conductors contained within a catheter, the conductors connecting the pacer pulse generator output to electrodes in electrical contact with the heart. Because the size and shape of the human body varies from person to person, and for other medical and commercial reasons, catheters are not permanently sealed to the pacer. Thus, there exists a mechanical connection or fitting between the catheter assembly and the pacer itself and this connection is subject to hostile body environment. It is through this connection that fluid leakage may occur. These unwanted fluids can cause a pacers electronic circuitry to short-circuit, and can cause other metal parts within a pacer to corrode. This situation leads to reduced pacer performance, if not complete failure and is a severe problem.
A malfunctioning pacer is usually removed by surgical procedure and replaced. It is unfortunate that a pacer which would otherwise have additional years of operational life must be removed because of a liquid leak. The unfortunate patient is subjected to surgical procedures which he may otherwise not have to endure so frequently. This has been a shortcoming of prior art pacers over the years.
Applicants present invention provides a solution to this problem of bodily fluid pacer leakage. The solution is commercially embodied in the Mark II pacer of the American Optical Corporation, which has proven to be capable of virtually completely eliminating this leakage problem.
SUMMARY OF THE INVENTION In an implantable heart pacer which is constructed in a manner to segregate the electronics portion from the remaining portions of the pacer, and where all pacer components and conductors are potted in an epoxy insulation, there are two extending conductors connecting this electronics portion or package to the electrode throat or connector. The electrode throat is adapted to be connected to a catheter for conductive connection to the patients heart. Leakage from the body of the patient into the throat and along the extending conductors is halted by separate shields or partitions through which each conductor passes, to which each conductor is soldered, and with which the epoxy insulation is bonded. It is the bonding of the epoxy insulation to the shields (which may likewise be constructed from materials related to the epoxy family of materials or from printed circuit board material) that creates the leak stop. Thus, any external bodily fluids leaking into the pacer on these extending conductors are blocked by the shields. Accordingly, advantages of the present invention include elimination of frequent surgical procedures to replace inoperative pacers due to leakage failure.
It is thus an object of the present invention to provide an improved heart stimulating device.
It is another object of the present invention to provide an improved implantable heart pacer.
It is yet another object of the present invention to extend usable life of an implanted pacer beyond that which it would have had if a fluid leak developed.
It is a still further object of the present invention to provide a liquid leak stop or shield to prevent external bodily fluids from causing premature implantable pacer failure.
Other objects and advantages will become apparent to those skilled in the art after referral to a detailed description of the appended drawings wherein:
BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 depicts an illustrative embodiment of the present invention;
FIG. 2 depicts certain details of the illustrative embodiment of FIG. 1; I
FIG. 3 depicts an alternative embodiment of the detail of FIG. 2; and
FIG. 4 depicts an interconnection of the functional blocks of the illustrative embodiment of FIG. 1 and their connection to the heart of a patient.
DESCRIPTION OF THE PREFERRED EMBODIMENTS Referring to FIG. 1, implantable pacer 10 contains batteries 12, 13, 14, 15, and 16 connected in a manner to provide appropriate supply voltage on conductors l7 and 18 to electronics 19. The batteries are depicted as being connected in parallel, but a series connection is likewise suitable and generally used. Reference numeral l9 depicts an enclosure for the electronics portion of pacer l0. Semi-conductors and other components interconnected thereto are contained within enclosure 19 which is intended to act as an RF shield and as a protective device against other harmful physical effects. (US. Pat. Nos. 3,528,428 and 3,595,242 describe electronic circuitry which may be employed within enclosure 19. This subject matter is incorporated herein by reference.) Conductors 20 and 21 are connected between electronics 19 and catheter-throat or electrode-connector-reeeptacle 11. The catheter leading to the heart is not shown in FIG. 1. Conductors 20 and 21 extend input signals from the patients heart to the electronics and likewise provide output stimulation from the electronics to the patients heart. Connector aperture 11 is designed to receive electrodes for connection to the patients heart. Shields or partitions 22 and 23 encompass conductors 21 and 20 respectively. Epoxy insulation 122 is shown in proximity with shields 23 and 22 only, for purposes of clarity of illustration; but it is understood that the insulation extends throughout the interior of pacer 10.
Referring to FIG. 2, shield 23 is shown in an elevational view in more detail. Shield 23 contains hole 25 which is plated-through. Reference numeral 24 represents metallic deposition on both sides of shield 23 as well as on the inside surface of hole 25. Conductor is inserted through hole and is soldered to metallic deposition 24. Composition of shield 23 is selected to have certain properties including high and substantial adhesion or bonding with insulation I22. Usually insulation 122 is constructed from epoxy, and material for shield 23 can be selected from the same generic class of synthetics. In a preferred embodiment it is constructed from materials from which ordinary printed circuit boards are constructed, e.g., glass epoxy laminate.
FIG. 1 and FIG. 2, shows that bodily fluids (not shown) which may tend to leak into aperture 11 and which are transported along conductors 20 and 21 are abruptly halted in their movement by shields 23 and 22. The extremely tight bonding between surrounding epoxy insulation 122 and the shields prevents the bodily fluids from moving beyond the placement or location of the shields themselves.
FIG. 3 depicts an alternative embodiment of the present invention. Reference numeral 26 depicts a shield having two apertures 28 and 29. These apertures are conductively connected together by metallic deposit 27 which likewise is plated through each of the apertures. In actual use, two shields are needed as before. One shield 26 is needed for conductor 20 and the other shield 26 is needed for conductor 21. This alternative embodiment facilitates manufacturing assembly since each conductor need not be inserted through a hole and soldered thereto but merely has to be brought up to the hole and soldered to the metallic deposit. Other separate conductors are extended from the remaining apertures by soldering to the metallic deposits on the remaining apertures.
Finally, FIG. 4 depicts pacer l0 and functional blocks included therein. Power supply or batteries 44 supplies power to heartbeat detector 43 and pulse generator 42. Conductors 20 and 21 are extended to heart 41 as described earlier. Pulse generator 42 supplies stimulation impulses on conductors 45 and 46 which are connected to conductors 20 and 21 respectively. Likewise, conductors 47 and 48, which are connected to conductors 45 and 46 respectively, are extended back to the input of heartbeat detector 43 thereby providing means for sensing beating action of heart 41. Output of heartbeat detector 43 feeds input of pulse generator 42 and thus heartbeat detector 43 controls operation of pulse generator 42. Shields 23 and 22 are shown in connection with conductors 20 and 21 as noted earlier.
The invention may be embodied in yet other specific forms without departing from the spirit or essential characteristics thereof. Thus, the present embodiments are to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
What is claimed is:
I. An implantable heart pacer for providing stimulation to the heart of a patient. said pacer comprising terminal means for connection to said patients heart, pulse generator means for providing stimulation impulses. means comprising two conductor leads for extending said impulses to said terminal means, means for detecting the beating action of said patients heart. means responsive to operation of said detecting means for controlling said pulse generator means, battery means for energizing said pulse generator means and said detecting means, epoxy insulation encapsulating said extending means, said battery means, said detecting means, said controlling means, and said pulse generator means, and incompressible liquid leak stop means constructed from at least glass-epoxy laminate adheringly connected to said extending means and bonded with said insulation for preventing flow of liquid from said terminal means towards said pulse generator means along said extending means, and wherein said incompressible liquid leak stop means is formed as two separate shields with an aperture through each of said shields, the inside shield surface and adjacent shield periphery of each of said apertures having depos ited thereon a conductive metal, each of said apertures being adapted to receive one of said leads, and means for sealing said conductive metal around each of said leads in a manner to prevent said flow of liquid through each of said apertures, the remaining surface of each of said shields being bonded to said insulation whereby said flow of liquid is prevented from flowing around each of said shields.
2. An implantable heart pacer for providing stimulation to the heart of a patient, said pacer comprising terminal means for connection to said patient's heart, pulse generator means for providing stimulation impulses. means comprising at least one conductor lead for extending said impulses to said terminal means, means for detecting the beating action of said patients heart, means responsive to operation of said detecting means for controlling said pulse generator means, battery means for energizing said pulse generator means and said detecting means, epoxy insulation encapsulating said extending means, said battery ,means, said detecting means, said controlling means, and said pulse generator means, and incompressible liquid leak stop means comprising at least one incompressible shield with an aperture therethrough, conductive metal, the inside shield surface and adjacent shield periphery of said aperture having adheringly deposited thereon said conductive metal. said aperture being adapted to receive said lead, and means for sealing said conductive metal around said lead in a manner to prevent flow of liquid from said terminal means towards said pulse generator means through said aperture, the remaining surface of said shield being bonded to said insulation whereby said flow of liquid is prevented from flowing around said shield.
3. A pacer as recited in claim 2 and wherein said incompressible shicld means is constructed from at least glass-cpoxy laminate.

Claims (3)

1. An implantable heart pacer for providing stimulation to the heart of a patient, said pacer comprising terminal means for connection to said patient''s heart, pulse generator means for providing stimulation impulses, means comprising two conductor leads for extending said impulses to said terminal means, means for detecting the beating action of said patient''s heart, means responsive to operation of said detecting means for controlling said pulse generator means, battery means for energizing said pulse generator means and said detecting means, epoxy insulation encapsulating said extending means, said battery means, said detecting means, said controlling means, and said pulse generator means, and incompressible liquid leak stop means constructed from at least glass-epoxy laminate adheringly connected to said extending means and bonded with said insulation for preventing flow of liquid from said terminal means towards said pulse generator means along said extending means, and wherein said incompressiblE liquid leak stop means is formed as two separate shields with an aperture through each of said shields, the inside shield surface and adjacent shield periphery of each of said apertures having deposited thereon a conductive metal, each of said apertures being adapted to receive one of said leads, and means for sealing said conductive metal around each of said leads in a manner to prevent said flow of liquid through each of said apertures, the remaining surface of each of said shields being bonded to said insulation whereby said flow of liquid is prevented from flowing around each of said shields.
2. An implantable heart pacer for providing stimulation to the heart of a patient, said pacer comprising terminal means for connection to said patient''s heart, pulse generator means for providing stimulation impulses, means comprising at least one conductor lead for extending said impulses to said terminal means, means for detecting the beating action of said patient''s heart, means responsive to operation of said detecting means for controlling said pulse generator means, battery means for energizing said pulse generator means and said detecting means, epoxy insulation encapsulating said extending means, said battery means, said detecting means, said controlling means, and said pulse generator means, and incompressible liquid leak stop means comprising at least one incompressible shield with an aperture therethrough, conductive metal, the inside shield surface and adjacent shield periphery of said aperture having adheringly deposited thereon said conductive metal, said aperture being adapted to receive said lead, and means for sealing said conductive metal around said lead in a manner to prevent flow of liquid from said terminal means towards said pulse generator means through said aperture, the remaining surface of said shield being bonded to said insulation whereby said flow of liquid is prevented from flowing around said shield.
3. A pacer as recited in claim 2 and wherein said incompressible shield means is constructed from at least glass-epoxy laminate.
US442536A 1974-02-14 1974-02-14 Liquid leak stop for an implantable heart pacer Expired - Lifetime US3906959A (en)

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US442536A US3906959A (en) 1974-02-14 1974-02-14 Liquid leak stop for an implantable heart pacer
DE2505029A DE2505029C2 (en) 1974-02-14 1975-02-06 Implantable pacemaker with liquid seal
JP50016996A JPS50114892A (en) 1974-02-14 1975-02-12
GB6384/75A GB1498529A (en) 1974-02-14 1975-02-14 Implantable heart pacer

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3986514A (en) * 1973-11-23 1976-10-19 American Optical Corporation Battery for use with implantable heart pacer
US4124029A (en) * 1976-10-20 1978-11-07 United Kingdom Atomic Energy Authority Heart pacemakers
US4164220A (en) * 1975-07-23 1979-08-14 Fisher & Paykel Limited Electronic temperature sensors
US20050267596A1 (en) * 2004-05-03 2005-12-01 Fulfillium, Inc. A Delaware Corporation Devices and systems for gastric volume control
US20060111777A1 (en) * 2004-11-19 2006-05-25 Fulfillium, Inc. Wireless breach detection
US9456915B2 (en) 2004-11-19 2016-10-04 Fulfilium, Inc. Methods, devices, and systems for obesity treatment

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US3478746A (en) * 1965-05-12 1969-11-18 Medtronic Inc Cardiac implantable demand pacemaker
US3735766A (en) * 1971-04-19 1973-05-29 Gen Electric Optional unipolar-bipolar body organ stimulator

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US3528428A (en) * 1968-04-11 1970-09-15 American Optical Corp Demand pacer
US3595242A (en) * 1969-03-26 1971-07-27 American Optical Corp Atrial and ventricular demand pacer
DE2053728C3 (en) * 1969-11-03 1980-03-06 Devices Ltd., Welwyn Garden City, Hertfordshire (Ver. Koenigreich) Implantable electrical device and method of making the same
US3822707A (en) * 1972-04-17 1974-07-09 Cardiac Pacemakers Inc Metal-enclosed cardiac pacer with solid-state power source

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US3478746A (en) * 1965-05-12 1969-11-18 Medtronic Inc Cardiac implantable demand pacemaker
US3735766A (en) * 1971-04-19 1973-05-29 Gen Electric Optional unipolar-bipolar body organ stimulator

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3986514A (en) * 1973-11-23 1976-10-19 American Optical Corporation Battery for use with implantable heart pacer
US4164220A (en) * 1975-07-23 1979-08-14 Fisher & Paykel Limited Electronic temperature sensors
US4124029A (en) * 1976-10-20 1978-11-07 United Kingdom Atomic Energy Authority Heart pacemakers
US20050267596A1 (en) * 2004-05-03 2005-12-01 Fulfillium, Inc. A Delaware Corporation Devices and systems for gastric volume control
US20050267595A1 (en) * 2004-05-03 2005-12-01 Fulfillium, Inc., A Delaware Corporation Methods for gastric volume control
US8066780B2 (en) 2004-05-03 2011-11-29 Fulfillium, Inc. Methods for gastric volume control
US20090275973A1 (en) * 2004-05-03 2009-11-05 Fulfillium, Inc. Devices and systems for gastric volume control
WO2006055839A3 (en) * 2004-11-19 2006-08-24 Fulfillium Inc Wireless breach detection
WO2006055839A2 (en) 2004-11-19 2006-05-26 Fulfillium, Inc. Wireless breach detection
US20060111632A1 (en) * 2004-11-19 2006-05-25 Fulfillium, Inc. Wireless breach detection
US20060111777A1 (en) * 2004-11-19 2006-05-25 Fulfillium, Inc. Wireless breach detection
US8070807B2 (en) 2004-11-19 2011-12-06 Fulfillium, Inc. Wireless breach detection
US9456915B2 (en) 2004-11-19 2016-10-04 Fulfilium, Inc. Methods, devices, and systems for obesity treatment
US9808367B2 (en) 2004-11-19 2017-11-07 Fulfillium, Inc. Methods, devices, and systems for obesity treatment
US10179060B2 (en) 2004-11-19 2019-01-15 Fulfillium, Inc. Methods, devices, and systems for obesity treatment
US10285835B2 (en) 2004-11-19 2019-05-14 Fulfillium, Inc. Methods, devices, and systems for obesity treatment
US10524946B2 (en) 2004-11-19 2020-01-07 Fulfillium, Inc. Methods, devices, and systems for obesity treatment
US11026825B2 (en) 2004-11-19 2021-06-08 Fulfillium, Inc. Methods, devices, and systems for obesity treatment

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GB1498529A (en) 1978-01-18

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