US3903888A - Time-delay metering dispenser - Google Patents

Time-delay metering dispenser Download PDF

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Publication number
US3903888A
US3903888A US45000874A US3903888A US 3903888 A US3903888 A US 3903888A US 45000874 A US45000874 A US 45000874A US 3903888 A US3903888 A US 3903888A
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Prior art keywords
medicament
reservoir
device
time
means
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Expired - Lifetime
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Joseph S Buelow
Thomas S Reid
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3M Co
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3M Co
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015Devices specially adapted for taking medicines
    • A61J7/0053Syringes, pipettes or oral dispensers
    • AHUMAN NECESSITIES
    • A46BRUSHWARE
    • A46BBRUSHES
    • A46B11/00Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water
    • A46B11/001Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water with integral reservoirs
    • A46B11/002Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water with integral reservoirs pressurised at moment of use manually or by powered means
    • A46B11/0041Flexible or deformable reservoirs, e.g. resilient bulbs, compressible tubes
    • AHUMAN NECESSITIES
    • A46BRUSHWARE
    • A46BBRUSHES
    • A46B11/00Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water
    • A46B11/001Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water with integral reservoirs
    • A46B11/002Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water with integral reservoirs pressurised at moment of use manually or by powered means
    • A46B11/0058Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water with integral reservoirs pressurised at moment of use manually or by powered means with a metered dosage

Abstract

A device suitable for dispensing medicament fluids in repeated dosage amounts on a time-delay basis comprises an applicator head and a handle having a primary first reservoir containing a quantity of medicament fluid to be dispensed within the handle. A single dosage containing second reservoir is contained within the applicator head and has dispensing means in communication with the head. A filling means positively fills the dosage reservoir from the primary first reservoir over a predetermined delay time generally not less than 30 minutes.

Description

United States Patent 1191 Buelow et a1. 1 1 Sept. 9, 1975 [54] TlNlE-DELAY METERING DISPENSER 1741042 4/1956 Burgin 4. 401/185 2.971.518 2/1961 ONeal 1 1 401/150 175] lnvgmorsl Joseph 3.469578 9/1909 Bicrman 128/232 x g a'f Reld Lmle CamdlL bolh 3 659 600 5/1972 Merrill 128/260 inn.

FOREIGN PATENTS OR APPLICATIONS [73] Assignee: Minnesota Mining and Manufacturing Com any st Paul 523340 4/1956 Canada 401/150 p 806.424 12/1936 France 401/146 Minn.

1 1 Filedi 1974 Primary ExaminerRicharCl A. Gaudet [2] 1 App!) No: 450 008 Assistant Examiner]. C. McGowan Attorney, Agent, or FirmAlexander, Sell, Steldt &

DeLziHunt [52] US. Cl. 128/222; 401/150; 401/187; 401/270; 128/260; 222/187 lnt. c121... A61J 7/00; 843K 5/18; B67D 3/00 1571 ABSTRACT [58] Field of Search 128/222, 260. 261 269, A device suitable for dispensing medicament fluids in 128/62 A; 222/92 106, 187, 205, 325, repeated dosage amounts on a time-delay basis c0m- 326; 132/84; 401/119. 133-135 151, prises an applicator head and a handle having a pri- 156 171, 176, 178 183. 186 198. 270, 278, mary first reservoir containing a quantity of medica 150. 146 ment fluid to be dispensed within the handle. A single dosage containing second reservoir is contained within [56] References Cited the applicator head and has dispensing means in c0m- UNITED STATES PATENTS munication with the head. A filling means positively HEM)! MW]: Fcrcnczy am/Isl X fills the dosage reservo r from the primary first reser- 554 5,1916 (mum I 222M voir over a predetermined delay time generally not mnwm 11/1920 Winn .1 401/148 than 30 minutes- 1 hl5.1l14 1/1927 Walker... 401/ 1200.277 5/1933 Dennis 401/143 21 Drawmg figures TIME-DELAY METERING DISPENSER BACKGROUND OF THE INVENTION 1. Field of the Invention In one aspect this invention relates to tooth brushing. In another aspect this invention relates to dispensing brushes suitable for dispensing medicinal fluids.

2. Prior Art Fountain or dispensing tooth brushes are known in the art; examples are disclosed in US. Pat. Nos. l,l68,965 issued to Rosenblum; 1,676,60] issued to Cavanaugh; 2,814,8I6 issued to Pepping et al.', 2,987,743 issued to Capps; and 3,256,894 issued to Sherman. These tooth brushes disclose various mechanisms for storing and dispensing quantities of a fluid or semi-solid material to the bristles of a tooth brush.

Many materials are known to be of value in the prevention and/or treatment of oral disease. Examples include fluorides such as sodium fluoride, antibiotics, e.g. tetracycline, and bactericides, e.g. chlorhexidine. In general. these materials share the problem of toxicity when administered in large doses. Therefore, the dosage of these materials applied by a dispensing brush containing such materials is important and must be regulated. Prior art brushes do not provide means for applying a measured dose and preventing multiple doses which might prove harmful.

BRIEF SUMMARY OF THE INVENTION Briefly. the applicator of this invention overcomes the problems inherent in the prior art. The applicator formed is suitable for dispensing repeated dosage amounts but on a time-delayed basis so that an overdose of the medicament is prevented and a therapeutic dose assured. The applicator of this invention comprises generally an applicating head having attached thereto suitable medicament spreading means and a handle means attached to the applicating head. A primary reservoir containing a quantity of medicament fluid to be dispensed, said quantity constituting a plurality of single doses. is contained within the handle attached to the head and a single dosage reservoir is contained within said head. The dosage reservoir is emptied by gravity or alternately has a dispensing means which positively delivers the contents of the dosage reservoir to the spreading means. A time-delayed filling means connects the primary reservoir to the dosage reservoir. the filling means being adapted to positively fill the dosage reservoir over a predetermined time. but in not less than about 30 minutes. There may be activating means mounted on the handle to positively empty the dosage reservoir on the spreading means. When the activating means are used. a single dose of medicament. in a predetermined amount is delivered to the spreading means. Following delivery of the medicamerit to the spreading means. a second dose cannot be dispensed immediately. thereby insuring against an overdose. After the passage of a period of time, generally at least 30 minutes. the dosage reservoir will be refilled and a repeat application is possible.

BRIEF DESCRIPTION OF THE DRAWING A further understanding can be had by referring to the accompanying drawing in which:

I"I(i I is a top view of one embodiment of the dis pensing tooth brush of this invention;

FIG. 2 is a cross-sectional view taken along the line 22 of FIG. I; and

FIG. 3 is an exploded perspective view of the brush of FIG. 1.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Referring to the accompanying drawing in which like reference numerals refer to like parts in the several views, a tooth brush 10 has a handle 12 and brush head 14. The handle 12 has a collapsible storage reservoir 16 disposed therein communicating with a dosage reservoir 18 which has a duct 20 connecting the dosage reservoir with bristles 22.

In greater detail, as shown the handle 12 and brush head 14 can be formed of one piece of solid material such as injection molded plastic. The collapsible storage reservoir 16 is mounted within a hollow portion of handle 12 and has an aperture 24 which is closed by a semi-permeable membrane 26. The membrane is held in place over aperture 24 by a coupling 28. The coupling also serves, in conjunction with shaped portion 30 of the brush handle 14, to hold the collapsible primary reservoir 16 in fluid communication with the dosage reservoir 18. The semi-permeable membrane 26 insures that the release of medicinal fluid into dosage reservoir 18 will take place over a substantial period of time and that multiple doses of medicament are not fed into and out of the dosage reservoir over a short period of time. The dosage reservoir 18 contains a sponge 32 which is capable of absorbing and holding a single dose of medicament within the dosage reservoir 18. The sponge insures that the entire dose of medicament will be held within the dosage reservoir until activation of the brush so that a full dose is delivered upon activation, also, after filling of the dosage reservoir 18 the medicament will not continuously drain through duct 20 onto the bristles.

When it is desired to dispense a dose of medicament, a plunger assembly comprising plunger 34, spring 36 and O-ring 38 is pushed downward, the bottom surface of plunger 34 squeezing sponge 38 to a compressed state and releasing the medicament imbibed therein into duct 20. The imbibed medicament flows through duct 20 and onto the bristles 22 of brush 14. After activation spring 36 returns the plunger 34 to the upper open position allowing sponge 32 to expand to its uncompressed state and imbibe additional medicament as it permeates through the semi-permeable membrane 26.

The applicator of this invention is useful, e.g. for safely dispensing measured amounts of medicinal agents into the buccal cavity for the prevention or treatment of oral disease. An effective medicament is a solution of sodium fluoride of about 5 percent concentration by weight. It is also useful in dispensing other medicaments operational in the buccal cavity including soluble inorganic fluorides, antibiotics such as tetracycline, and bactericides such as chlorhexidine. The time delay metered dosage form brush may also be used for application of medicaments to external portions of a body where one wants the combination of medicament delivery and cleansing action achievable with a brush sponge or the like.

The handle and applicating head of this invention can be made as a unit such as shown in FIG. I or may be made separately and only a portion of the device replaced when necessary. Suitable materials for forming the handle and applicating head are low creep plastics e.g. cellulose propionate. The materials can be selected on the basis of cost, ease of manufacture, nonreactivity with the medicament to be dispensed as well as other processing variables.

The spreading means can comprise bristles such as those commonly used in tooth brushes, sponges, fiberous or non-woven pads and similar porous applicating and spreading means well known in the art.

What is claimed is:

l. A device suitable for dispensing medicinal fluids in repeated measured dosage amounts with predetermined minimum time delay between consecutive doses comprising:

an applicator head embodying a medicament spreading means;

a handle means attached to said head;

a first reservoir containing a quantity of medicament fluid constituting a plurality of single doses contained within said handle means",

a second reservoir for containing and storing a single dose amount of said fluid medicament within said handle means;

dispensing means adapted to deliver the medicament fluid contained in said second reservoir to said medicament spreading means; and time-delayed filling means connecting said first reservoir and said second reservoir, said means being adapted to positively refill said second reservoir over a predetermined period of time not less than about minutes;

whereby after each dose of medicament of predetermined amount has been delivered to the applicator head for application of said medicament to a desired area for treatment said device will dispense a following dose of medicament only after said predetermined period of time.

2. The device of claim 1 where said time-delayed filling means is a capillary tube.

3. The device of claim I where said time-delayed filling means is a semi-permeable membrane.

4. The device of claim 1 where said second reservoir has a sponge contained therein to retain the medicament.

5. The device of claim 1 where said medicament is an aqueous solution of stannous fluoride.

6. The device of claim 1 where said medicament is an aqueous solution of sodium fluoride.

7. The device of claim 1 where said medicament is an aqueous solution of fluoride ion producing compound.

8. The device of claim 1 where said medicament is a solution of antibiotic.

9. The device of claim 8 where said medicament is a solution of tetracycline.

10. The device of claim I where said medicament is a solution of antibacterial agent.

I]. The device of claim 10 wherein the medicament is a solution of chlorhexidine.

12. The device of claim 1 having means associated with said second reservoir to positively empty said res ervoir when it is desired to dispense the medicament.

13. The article of claim 6 where said means connecting said second reservoir and said first reservoir comprises a permeable membrane.

14. The article of claim 6 where said second reservoir is refilled with a single dose of fluid medicament over a period of about 30 minutes to 4 hours.

15. A tooth brush suitable for dispensing repeated dosage amounts of a fluid medicament on a time-delay basis comprising:

a brush head having attached thereto a plurality of bristles suitable for cleaning teeth;

a handle attached to said head;

a first reservoir containing multiple dose amounts of fluid medicament contained within said handle;

a second reservoir for containing a single dose amount of said medicament within said handle and containing a spongelike fluid-holding material; a fluid duct connecting said second reservoir with said brush head; a time-delayed filling means connecting said first reservoir and said second reservoir adapted to fill said second reservoir over a pre' determined period of time not less than about 30 minutes; and

means adapted to compress said fluid-holding material in said second reservoir thereby delivering a single dose of medicament to said brush and allowing the application of a following dose of medicament only after said predetermined period of time.

16. The tooth brush of claim 15 where said medicament is one which is normally unstable when mixed with toothpaste.

T7. The article of claim 15 where said medicament is a solution of sodium fluoride.

18. The article of claim 15 where said medicament is a solution of stannous fluoride.

19. The article of claim 15 where said medicament is a solution of fluoride ion producing compound.

20. The article of claim 15 where said medicament is a solution of tetracycline.

2]. The article of claim 15 where said medicament is a solution of chlorhexidine.

UNITED STATES PATENT AND TRADEMARK OFFICE CERTIFICATE OF CORRECTIGN PATENT NO. 3,903,888

DATED September 9, 1975 I W) I Buelow and Reid It is certified that error appears in the above-identified patent and that said Letters Patent are hereby corrected as shown below:

In the abstract, lines 3 & t, delete "primary".

In the abstract, line 7, for "applicator head" insert hand1e- In the abstract, line 9, delete "primary".

Signal and Scaled this second Day of December 1975 {SEAL} Arrest:

RUTH C. MASON C. MARSHALL DAMN Arresting ()fl'icer Commissioner of Parents and Trldtmlris

Claims (21)

1. A device suitable for dispensing medicinal fluids in repeated measured dosage amounts with predetermined minimum time delay between consecutive doses comprising: an applicator head embodying a medicament spreading means; a handle means attached to said head; a first reservoir containing a quantity of medicament fluid constituting a plurality of single doses contained within said handle means; a second reservoir for containing and storing a single dose amount of said fluid medicament within said handle means; dispensing means adapted to deliver the medicament fluid contained in said second reservoir to said medicament spreading means; and time-delayed filling means connecting said first reservoir and said second reservoir, said means being adapted to positively refill said second reservoir over a predetermined period of time not less than about 30 minutes; whereby after each dose of medicament of predetermined amount has been delivered to the applicator head for application of said medicament to a desired area for treatment said device will dispense a following dose of medicament only after said predetermined period of time.
2. The device of claim 1 where said time-delayed filling means is a capillary tube.
3. The device of claim 1 where said time-delayed filling means is a semi-permeable membrane.
4. The device of claim 1 where said second reservoir has a sponge contained therein to retain the medicament.
5. The device of claim 1 where said medicament is an aqueous solution of stannous fluoride.
6. The device of claim 1 where said medicament is an aqueous solution of sodium fluoride.
7. The device of claim 1 where said medicament is an aqueous solution of fluoride ion producing compound.
8. The device of claim 1 where said medicament is a solution of antibiotic.
9. The device of claim 8 where said medicament is a solution of tetracycline.
10. The device of claim 1 where said medicament is a solution of antibacterial agent.
11. The device of claim 10 wherein the medicament is a solution of chlorhexidine.
12. The device of claim 1 having means associated with said second reservoir to positively empty said reservoir when it is desired to dispense the medicament.
13. The article of claim 6 where said means connecting said second reservoir and said first reservoir comprises a permeable membrane.
14. The article of claim 6 where said second reservoir is refilled with a single dose of fluid medicament over a period of about 30 minutes to 4 hours.
15. A tooth brush suitable for dispensing repeated dosage amounts of a fluid medicament on a time-delay basis comprising: a brush head having attached thereto a plurality of bristles suitable for cleaning teeth; a handle attached to said head; a first reservoir containing multiple dose amounts of fluid medicament contained within said handle; a second reservoir for containing a single dose amount of said medicament within said handle and containing a spongelike fluid-holding material; a fluid duct connecting said second reservoir with said brush head; a time-delayed filling means connecting said first reservoir and said second reservoir adapted to fill said second reservoir over a predetermined period of time not less than about 30 minutes; and means adapted to compress said fluid-holding material in said second reservoir thereby delivering a single dose of medicaMent to said brush and allowing the application of a following dose of medicament only after said predetermined period of time.
16. The tooth brush of claim 15 where said medicament is one which is normally unstable when mixed with toothpaste.
17. The article of claim 15 where said medicament is a solution of sodium fluoride.
18. The article of claim 15 where said medicament is a solution of stannous fluoride.
19. The article of claim 15 where said medicament is a solution of fluoride ion producing compound.
20. The article of claim 15 where said medicament is a solution of tetracycline.
21. The article of claim 15 where said medicament is a solution of chlorhexidine.
US3903888A 1974-03-11 1974-03-11 Time-delay metering dispenser Expired - Lifetime US3903888A (en)

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Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4175879A (en) * 1976-05-31 1979-11-27 Pietro Molinari Toothbrush
US4291685A (en) * 1979-06-15 1981-09-29 Taelman Dennis L Therapeutic heat and cosmetic applicator
US4464171A (en) * 1982-03-29 1984-08-07 Garwin Mark J Intravascular insertion apparatus and method
EP0290873A2 (en) * 1987-05-13 1988-11-17 Kao Corporation Toothbrush
US4840510A (en) * 1986-10-29 1989-06-20 Kabushiki Kaisha Yaita Seisakusho Container with brush and fluid metering unit for fluid type cosmetics
US5017036A (en) * 1987-10-13 1991-05-21 Gerda Vidovic Toothbrush with absorbent pad
US5208933A (en) * 1990-11-09 1993-05-11 L. Paul Lustig Dental tool with liquid dispensing, and cartridge
US5338124A (en) * 1993-06-17 1994-08-16 Spicer Zorroz W Water squirt toothbrush
US5918995A (en) * 1995-12-15 1999-07-06 Puurunen; Juha-Pekka Toothbrush with pump
US20050129453A1 (en) * 2003-12-15 2005-06-16 Michael Bravo-Loubriel Toothbrush for prevention treatment of tooth sensitivity and method therefor
US20060163282A1 (en) * 2003-10-03 2006-07-27 Kao Corporation Dispensing device
US20100114071A1 (en) * 2008-11-06 2010-05-06 Carl Braunagel Apparatus for cleaning a nasal cavity
US20100284726A1 (en) * 2009-05-05 2010-11-11 Frank Ottaviani Liquid Dentifrice Dispensing Toothbrush
US20110211901A1 (en) * 2010-02-26 2011-09-01 Colgate-Palmolive Company Fluid delivery system for an oral care implement
US20110250008A1 (en) * 2008-12-29 2011-10-13 Toly Korea, Inc. Roller-type dual cosmetic case having airless pump
US20120016319A1 (en) * 2010-07-16 2012-01-19 Christian Javier Zino Gutierrez Substance dispenser, especially for medical or cosmetic treatment
US20120271242A1 (en) * 2009-05-20 2012-10-25 Sanofi-Aventis Deutschland Gmbh Assembly for use in a drug delivery device
US8360668B1 (en) 2008-10-07 2013-01-29 Hinnant Wayne M Scrub brush
US8398326B2 (en) 2010-03-04 2013-03-19 Colgate-Palmolive Company Fluid dispensing oral care implement
US8444416B2 (en) 2005-04-26 2013-05-21 Braun Gmbh Valves for personal care devices
US8458841B2 (en) 2007-06-20 2013-06-11 Braun Gmbh Brush head for a toothbrush
US20140050515A1 (en) * 2011-04-14 2014-02-20 Thomas Bruder Cosmetic dispenser
US9144298B2 (en) 2010-01-29 2015-09-29 Colgate-Palmolive Company Oral care fluid delivery system
US9554641B2 (en) 2012-10-26 2017-01-31 Colgate-Palmolive Company Oral care implement

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1028011A (en) * 1911-09-06 1912-05-28 Lajos Ferenczy Envelop-moistener.
US1182554A (en) * 1916-01-31 1916-05-09 Christopher A Garvey Fountain-brush.
US1606860A (en) * 1926-06-21 1926-11-16 William F Winn Weed eliminator
US1615104A (en) * 1925-08-29 1927-01-18 Joseph D Walker Fountain brush
US1860277A (en) * 1931-10-21 1932-05-24 Dennis William Brush
US2743042A (en) * 1953-06-16 1956-04-24 Luther B Burgin Fountain toothbrush
US2971518A (en) * 1958-09-08 1961-02-14 James C O'neal Toothbrush with toothpaste dispenser
US3469578A (en) * 1965-10-12 1969-09-30 Howard R Bierman Infusion device for ambulatory patients with flow control means
US3659600A (en) * 1970-02-24 1972-05-02 Estin Hans H Magnetically operated capsule for administering drugs

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1028011A (en) * 1911-09-06 1912-05-28 Lajos Ferenczy Envelop-moistener.
US1182554A (en) * 1916-01-31 1916-05-09 Christopher A Garvey Fountain-brush.
US1615104A (en) * 1925-08-29 1927-01-18 Joseph D Walker Fountain brush
US1606860A (en) * 1926-06-21 1926-11-16 William F Winn Weed eliminator
US1860277A (en) * 1931-10-21 1932-05-24 Dennis William Brush
US2743042A (en) * 1953-06-16 1956-04-24 Luther B Burgin Fountain toothbrush
US2971518A (en) * 1958-09-08 1961-02-14 James C O'neal Toothbrush with toothpaste dispenser
US3469578A (en) * 1965-10-12 1969-09-30 Howard R Bierman Infusion device for ambulatory patients with flow control means
US3659600A (en) * 1970-02-24 1972-05-02 Estin Hans H Magnetically operated capsule for administering drugs

Cited By (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4175879A (en) * 1976-05-31 1979-11-27 Pietro Molinari Toothbrush
US4291685A (en) * 1979-06-15 1981-09-29 Taelman Dennis L Therapeutic heat and cosmetic applicator
US4464171A (en) * 1982-03-29 1984-08-07 Garwin Mark J Intravascular insertion apparatus and method
US4840510A (en) * 1986-10-29 1989-06-20 Kabushiki Kaisha Yaita Seisakusho Container with brush and fluid metering unit for fluid type cosmetics
EP0290873A2 (en) * 1987-05-13 1988-11-17 Kao Corporation Toothbrush
EP0290873A3 (en) * 1987-05-13 1989-10-04 Kao Corporation Toothbrush
US4963046A (en) * 1987-05-13 1990-10-16 Kao Corporation Toothbrush
US5017036A (en) * 1987-10-13 1991-05-21 Gerda Vidovic Toothbrush with absorbent pad
US5208933A (en) * 1990-11-09 1993-05-11 L. Paul Lustig Dental tool with liquid dispensing, and cartridge
US5338124A (en) * 1993-06-17 1994-08-16 Spicer Zorroz W Water squirt toothbrush
US5918995A (en) * 1995-12-15 1999-07-06 Puurunen; Juha-Pekka Toothbrush with pump
US20060163282A1 (en) * 2003-10-03 2006-07-27 Kao Corporation Dispensing device
US20050129453A1 (en) * 2003-12-15 2005-06-16 Michael Bravo-Loubriel Toothbrush for prevention treatment of tooth sensitivity and method therefor
US7213995B2 (en) * 2003-12-15 2007-05-08 Michael Bravo-Loubriel Toothbrush for prevention treatment of tooth sensitivity and method therefor
US8444416B2 (en) 2005-04-26 2013-05-21 Braun Gmbh Valves for personal care devices
US8458841B2 (en) 2007-06-20 2013-06-11 Braun Gmbh Brush head for a toothbrush
US8360668B1 (en) 2008-10-07 2013-01-29 Hinnant Wayne M Scrub brush
US8888395B1 (en) 2008-10-07 2014-11-18 Wayne M. Hinnant Scrub brush
US20100114071A1 (en) * 2008-11-06 2010-05-06 Carl Braunagel Apparatus for cleaning a nasal cavity
US8808317B2 (en) * 2008-11-06 2014-08-19 Carl Braunagel Apparatus for cleaning a nasal cavity
US20110250008A1 (en) * 2008-12-29 2011-10-13 Toly Korea, Inc. Roller-type dual cosmetic case having airless pump
US20100284726A1 (en) * 2009-05-05 2010-11-11 Frank Ottaviani Liquid Dentifrice Dispensing Toothbrush
US8087843B2 (en) * 2009-05-05 2012-01-03 Frank Ottaviani Liquid dentifrice dispensing toothbrush
US20120271242A1 (en) * 2009-05-20 2012-10-25 Sanofi-Aventis Deutschland Gmbh Assembly for use in a drug delivery device
US9220839B2 (en) * 2009-05-20 2015-12-29 Sanofi-Aventis Deutschland Gmbh Assembly for use in a drug delivery device
US9144298B2 (en) 2010-01-29 2015-09-29 Colgate-Palmolive Company Oral care fluid delivery system
US20110211901A1 (en) * 2010-02-26 2011-09-01 Colgate-Palmolive Company Fluid delivery system for an oral care implement
CN102762125A (en) * 2010-02-26 2012-10-31 高露洁-棕榄公司 Fluid delivery system for an oral care implement
US8506196B2 (en) * 2010-02-26 2013-08-13 Colgate-Palmolive Company Fluid delivery system for an oral care implement
CN102762125B (en) * 2010-02-26 2015-06-03 高露洁-棕榄公司 Fluid delivery system for an oral care implement
US8398326B2 (en) 2010-03-04 2013-03-19 Colgate-Palmolive Company Fluid dispensing oral care implement
US9648943B2 (en) 2010-03-04 2017-05-16 Colgate-Palmolive Company Fluid dispensing oral care implement
US20120016319A1 (en) * 2010-07-16 2012-01-19 Christian Javier Zino Gutierrez Substance dispenser, especially for medical or cosmetic treatment
US8337473B2 (en) * 2010-07-16 2012-12-25 Christian Javier Zino Gutierrez Substance dispenser, especially for medical or cosmetic treatment
US20140050515A1 (en) * 2011-04-14 2014-02-20 Thomas Bruder Cosmetic dispenser
US9629438B2 (en) * 2011-04-14 2017-04-25 Aptar Radolfzell Gmbh Cosmetic dispenser
US9554641B2 (en) 2012-10-26 2017-01-31 Colgate-Palmolive Company Oral care implement

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