US3885155A - Mass spectrometric determination of carbon 14 - Google Patents

Mass spectrometric determination of carbon 14 Download PDF

Info

Publication number
US3885155A
US3885155A US411801A US41180173A US3885155A US 3885155 A US3885155 A US 3885155A US 411801 A US411801 A US 411801A US 41180173 A US41180173 A US 41180173A US 3885155 A US3885155 A US 3885155A
Authority
US
United States
Prior art keywords
ions
mass
carbon
masses
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US411801A
Inventor
Michael Anbar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
Stanford Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanford Research Institute filed Critical Stanford Research Institute
Priority to US411801A priority Critical patent/US3885155A/en
Application granted granted Critical
Publication of US3885155A publication Critical patent/US3885155A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/28—Static spectrometers
    • H01J49/284—Static spectrometers using electrostatic and magnetic sectors with simple focusing, e.g. with parallel fields such as Aston spectrometer
    • H01J49/286—Static spectrometers using electrostatic and magnetic sectors with simple focusing, e.g. with parallel fields such as Aston spectrometer with energy analysis, e.g. Castaing filter
    • H01J49/288—Static spectrometers using electrostatic and magnetic sectors with simple focusing, e.g. with parallel fields such as Aston spectrometer with energy analysis, e.g. Castaing filter using crossed electric and magnetic fields perpendicular to the beam, e.g. Wien filter
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/12—Ion sources; Ion guns using an arc discharge, e.g. of the duoplasmatron type
    • H01J49/126—Other arc discharge ion sources using an applied magnetic field

Definitions

  • ABSTRACT A determination of the amount of carbon I4 in a substance is made simpler and more accurate by introducing the carbon 14 in the form of CO into a duoplasmatron negative ion source for a mass spectrometer together with "N producing CN, as the predominate ion. The spectrometer can then accurately detect the amount of carbon 14.
  • An object of this invention is to provide an analytical procedure that gives a more precise determination of C content than is available heretofore.
  • Another object of this invention is to provide an analytical procedure that enables a greater sensitivity in the determination of C content heretofore available.
  • Another object of this invention is to provide a radiocarbon assay technique which provides less exten sive pre-treatment and chemical processing than is re quired by present techniques.
  • Still another object of the invention is to provide a radiocarbon assay technique for C which requires smaller amounts of a sample and takes significantly less time than heretofore possible.
  • N predominant peaks which are formed have mass 27 and 28, with mass 29 uniquely representing the abundance of C.
  • the background of mass 29 in the negative ion spectrum is nill, unlike the positive ion spectrum counterpart where fragments of hydrocarbons and their oxidation products contribute to the mass 29 peak, making detection inaccurate. Therefore, the duoplasmatron negative ion spectrometer readily provides information whereby the amount of C present in the original sample can be determined.
  • the preparation of a sample for analysis utilizes standard and well known techniques.
  • the carbon sample which is desired to be analyzed is converted to CO by any well known technique such as by burning in the presence of oxygen or mixing with copper oxide and then burning.
  • the CO is then mixed with N and thereafter is introduced into a duoplasmatron negative ion source.
  • CO and N are atomized and the CN radicals formed are readily converted into CN, owing to the high electron affinity of CN.
  • the other ionization products which are formed are 0, NO, 0 and N0 Because N is energetically unstable, it is not formed.
  • the ionic peaks which are formed as a result of mixing the CO and N are C N (mass 26), C N and C 'N (mass 27), C N and C N (mass 28) and C N (mass 29).
  • the N which is mixed with the CO is highly enriched in N (greater than 98 percent N, is commen cially available at about 50 cents per milliliter).
  • the predominant peaks which will be formed have masses 27, 28 and 29 which latter mass uniquely represents the abundance of C.
  • the desired C/ C isotope ratio is measured by comparing mass 29 and 27.
  • the contribution of C N to mass 27 is less than 2 X 10 and its range of variation is only less than 1 X 10""; thus, it does not affect the precision desired. which is on the order of 0.1 percent, in the assessment of C present.
  • N lowers the overall detection sensitivity of C by a proportional amount (about 2%) without affecting the precision of the determination of the (f/ C isotope ratio. It should be noted that there is not background of mass 29 in the negative ion spectrum, unlike the positive ion spectrum counterpart where fragments of hydrocarbon C H; and their oxiditation products (CHOU contribute to the mass 29 peak,
  • the carbon sample which is to be analyzed, is oxidized to CO by conventional microanalytical techniques.
  • This is here represented as a source of CO 10. It is introduced into the negative ion duoplasmatron source 12, of the mass spectrometer 14, along with an appropriate amount of N from a source 16.
  • the CN ions are extracted and formed into 21 keV beam.
  • the relatively high energy of the beam (10 to 20 keV) is needed to obtain a high transmission with the required high resolution.
  • the ion beam is electrostatically deflected by deflector 18, into the mass separator chamber 20.
  • the mass separation is accomplished by means of a Wien velocity filter 22.
  • This commercially available device achieves mass resolution by applying uniform magnetic and electrostatic fields that are normal to each other and to the ion beam. Ions with a predetermined velocity have equal but opposite electric and magentic forces acting on them and consequently continue unde flected. Those ions with a lesser or greater velocity will be deflected in the plane of the electrostatic field. Since, for a given energy, the beam velocity is proportional to m/2, the Wein filter provides mass selection.
  • the Wien filter is adjusted to deflect mass 29 (C N) off axis to prevent neutrals from accompanying the beam and to increase the mass resolution
  • the off axis beam from mass 29 is represented by the line 30.
  • Mass 28 and 27 C N and C 'N) are deflected and detected simultaneously in two Faraday cup collectors, respectively 31 and 32.
  • the mass 27 and 28 beams are indicated by the lines, respectively 34,36.
  • the neutral beam component is represented by the line 38.
  • the magnetic deflector 22 separates ion species according to momentum and thus mass 27 or 28 ions that have scattered into the magnetic field are deflected by a greater angle than mass 29 ions.
  • An interceptor 40 blocks the neutral ion beam component from entering into the chamber of the mass spectrometer where the desired beam 30 enters through an opening in the interceptor 40.
  • the ion beam 30 which passes through the opening in the interceptor is then deflected again by a magnetic deflector 42 into an electron multiplier arrangement 44 which amplifies the ions, in the beam, converts them to electrical pulses and applies the pulses to a counter 46 to be counted.
  • the Faraday cup collectors respectfully 31 and 32, of mass 27 and 28 ion beams, are connected through the respective thermostatically compensated resistors 48 and 50, to ground.
  • the voltage developed at the top of these resistors, in response to the collection of ions, are applied to the respective voltage to frequency converters 52,54.
  • the output of the respective frequency converters is applied to frequency counters, respectively 56,58.
  • the system described produces a total of the C N ion counts, integrated by a sealer, 46, as well as the integrated secondary counts of masses 27 and 28. From this information, the isotope ratios C/C and C/"C can be calculated, after correction for any background from mass 28. From these ratios. using the appropriate half life value for C and any necessary corrections for C fractionation, the data of this sample can be determined.
  • a method of measuring carbon 14 content in a sample comprising converting carbon in said sample to CO mixing said CO with N converting said mixture of CO and N into CN ions having different masses including mass 29, separating said mass 29 CN ions from the ions having other masses, and
  • a method as recited in claim 1 wherein said step of converting said mixture of CO and "N into CN- ions comprises introducing said mixture into a duoplasmatron negative ion source.
  • said method further includes the steps of separating said ions having masses of 27 and 28 from each other, and
  • a method of determining the concentration of "C in a specimen comprising converting the carbon in said specimen to CO introducing said CO together with N into a plasma negative ion source, to form CN ions having different masses including masses 27, 28 and 29,

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

A determination of the amount of carbon 14 in a substance is made simpler and more accurate by introducing the carbon 14 in the form of CO2 into a duoplasmatron negative ion source for a mass spectrometer together with 15N2 producing CN , as the predominate ion. The spectrometer can then accurately detect the amount of carbon 14.

Description

United States Patent [191 Anbar MASS SPECTROMETRIC DETERMINATION OF CARBON I4 [75] Inventor: Michael Anbar, Palo Alto, Calif.
[73] Assignee: Stanford Research Institute, Menlo Park, Calif.
[22] Filed: Nov. 1,1973
[2]] App]. No: 411,801
52 115.0 250/283; 250/288 [51] rm. (:1. H0lj 39/28 [58] Field ofSearch 250/28l,282, 283,288
[56] References Cited UNITED STATES PATENTS 1/1974 Anbar et 250/288 OTHER PUBLICATIONS Characteristics of a Low Energy Duoplasmatron 5OURCE 5 OF CO2 N2 [451 May 20, 1975 Negative Ion Source," Aberth et al., Rev. of Sci. Inst., June 1967, pp. 745-748.
Primary ExaminerArchie R. Borchelt Assistant Examiner-B. C. Anderson Attorney, Agent, or Firm-Lindenberg. Freilich, Wasserman, Rosen & Fernandez [57] ABSTRACT A determination of the amount of carbon I4 in a substance is made simpler and more accurate by introducing the carbon 14 in the form of CO into a duoplasmatron negative ion source for a mass spectrometer together with "N producing CN, as the predominate ion. The spectrometer can then accurately detect the amount of carbon 14.
4 Claims, 1 Drawing Figure 52 J 56 VOIIETAGE FREQ TO REQ CONVERTER COUNTER VCLTAGE TO FREQ gg 'fi CONVERIER COUNTER MASS SPECTROMETRIC DETERMINATION OF CARBON 14 BACKGROUND OF THE INVENTION Radiobiological effects of radio isotopes make them undesirable as tracers in biological systems. The use of stable isotopes as tracers is therefore more desirable but, their use is limited by the background of their natural abundance, making detection extremely difficult if not impossible. Although, in many cases this limitation can be overcome by the use of multi-labeled molecular tracers, the latter cannot be used for a large number of small molecules, e.g., glycine, acetic or lactic acids, or for degradation studies where the products are small molecules, for example, CO formaldehyde, acetadehyde, or methylamine. C is the ideal and only practical tracer for such cases, only that the microcurie doses of such a long lived radioisotope make its use in routine clinical tests highly undersirable.
The same system as described above can also be used for radiocarbon dating if desired.
OBJECTS AND SUMMARY OF THE INVENTION An object of this invention is to provide an analytical procedure that gives a more precise determination of C content than is available heretofore.
Another object of this invention is to provide an analytical procedure that enables a greater sensitivity in the determination of C content heretofore available.
Yet, another object of this invention is to provide a radiocarbon assay technique which provides less exten sive pre-treatment and chemical processing than is re quired by present techniques.
Still another object of the invention is to provide a radiocarbon assay technique for C which requires smaller amounts of a sample and takes significantly less time than heretofore possible.
These and other objects of the invention are achieved by measuring the C content of a sample in the form of CN rather than in the form of CO ions. This is accomplished by introducing a mixture of CO derived from a sample desired to be analyzed, and into a plasma negative ion source such as duoplasmatron negative ion source, This produces CN as the predominate carbon containing ion. In the highly intense and hot plasma of the ion source, CO and N are atomized and the CN radicals formed are readily converted to CN, owing to the high electron affinity of CN. The other ionization products formed are of O, NO* and N Because N is energetically unstable, it is not formed. Included among the ionic peaks which are formed is C N (mass 29). Using N predominant peaks which are formed have mass 27 and 28, with mass 29 uniquely representing the abundance of C. The background of mass 29 in the negative ion spectrum is nill, unlike the positive ion spectrum counterpart where fragments of hydrocarbons and their oxidation products contribute to the mass 29 peak, making detection inaccurate. Therefore, the duoplasmatron negative ion spectrometer readily provides information whereby the amount of C present in the original sample can be determined.
The novel features of the invention are set forth with particularity in the appended claims. The invention will best be understood from the following description when read in conjunction with the accompanying drawing which illustrates the use of a negative ion mass spectrometer, in accordance with this invention, for determining the amount of carbon 14 in a sample.
DESCRIPTION OF THE PREFERRED EMBODIMENTS The preparation of a sample for analysis, in accordance with this invention, utilizes standard and well known techniques. The carbon sample which is desired to be analyzed is converted to CO by any well known technique such as by burning in the presence of oxygen or mixing with copper oxide and then burning. The CO is then mixed with N and thereafter is introduced into a duoplasmatron negative ion source. In the highly intense and hot plasma of this ion source, CO and N; are atomized and the CN radicals formed are readily converted into CN, owing to the high electron affinity of CN.
The other ionization products which are formed are 0, NO, 0 and N0 Because N is energetically unstable, it is not formed.
Now, the ionic peaks which are formed as a result of mixing the CO and N are C N (mass 26), C N and C 'N (mass 27), C N and C N (mass 28) and C N (mass 29).
The N which is mixed with the CO is highly enriched in N (greater than 98 percent N, is commen cially available at about 50 cents per milliliter). The predominant peaks which will be formed have masses 27, 28 and 29 which latter mass uniquely represents the abundance of C. Under these conditions, the desired C/ C isotope ratio is measured by comparing mass 29 and 27. The contribution of C N to mass 27 is less than 2 X 10 and its range of variation is only less than 1 X 10""; thus, it does not affect the precision desired. which is on the order of 0.1 percent, in the assessment of C present. The small amount of N accompanying N lowers the overall detection sensitivity of C by a proportional amount (about 2%) without affecting the precision of the determination of the (f/ C isotope ratio. It should be noted that there is not background of mass 29 in the negative ion spectrum, unlike the positive ion spectrum counterpart where fragments of hydrocarbon C H; and their oxiditation products (CHOU contribute to the mass 29 peak,
Referring now to the drawing, it is a schematic illustration of one type of mass spectrum showing how it may be used in accordance with this invention. The carbon sample, which is to be analyzed, is oxidized to CO by conventional microanalytical techniques. This is here represented as a source of CO 10. It is introduced into the negative ion duoplasmatron source 12, of the mass spectrometer 14, along with an appropriate amount of N from a source 16. The CN ions are extracted and formed into 21 keV beam. The relatively high energy of the beam (10 to 20 keV) is needed to obtain a high transmission with the required high resolution. By differential pumping and the use of high vac uum techniques, the background pressure and the mass deflection chamber can be reduced to 10 torr. The ion beam is electrostatically deflected by deflector 18, into the mass separator chamber 20.
Fast moving neutral atoms and molecules formed primarily in the high pressure region of the ionization source by charge exchange of the beam ions with background gas, continue undeflected and are thus prevented from entering into the mass separation chamber.
The mass separation is accomplished by means of a Wien velocity filter 22. This commercially available device achieves mass resolution by applying uniform magnetic and electrostatic fields that are normal to each other and to the ion beam. Ions with a predetermined velocity have equal but opposite electric and magentic forces acting on them and consequently continue unde flected. Those ions with a lesser or greater velocity will be deflected in the plane of the electrostatic field. Since, for a given energy, the beam velocity is proportional to m/2, the Wein filter provides mass selection.
The Wien filter is adjusted to deflect mass 29 (C N) off axis to prevent neutrals from accompanying the beam and to increase the mass resolution The off axis beam from mass 29 is represented by the line 30. Mass 28 and 27 C N and C 'N) are deflected and detected simultaneously in two Faraday cup collectors, respectively 31 and 32. The mass 27 and 28 beams are indicated by the lines, respectively 34,36. The neutral beam component is represented by the line 38. The magnetic deflector 22 separates ion species according to momentum and thus mass 27 or 28 ions that have scattered into the magnetic field are deflected by a greater angle than mass 29 ions.
An interceptor 40, blocks the neutral ion beam component from entering into the chamber of the mass spectrometer where the desired beam 30 enters through an opening in the interceptor 40. The ion beam 30 which passes through the opening in the interceptor is then deflected again by a magnetic deflector 42 into an electron multiplier arrangement 44 which amplifies the ions, in the beam, converts them to electrical pulses and applies the pulses to a counter 46 to be counted.
The Faraday cup collectors, respectfully 31 and 32, of mass 27 and 28 ion beams, are connected through the respective thermostatically compensated resistors 48 and 50, to ground. The voltage developed at the top of these resistors, in response to the collection of ions, are applied to the respective voltage to frequency converters 52,54. The output of the respective frequency converters is applied to frequency counters, respectively 56,58. Thus, the system described produces a total of the C N ion counts, integrated by a sealer, 46, as well as the integrated secondary counts of masses 27 and 28. From this information, the isotope ratios C/C and C/"C can be calculated, after correction for any background from mass 28. From these ratios. using the appropriate half life value for C and any necessary corrections for C fractionation, the data of this sample can be determined.
There has accordingly been described and shown here and above a novel and useful system for measuring the C content of carbon in the form of CN using a negative ion duoplasmatron mass spectrometer. This uniquely performs measurements using a biatomic ionic species thatcan be produced with a high yield and in which the second single atom is an enriched heavy isotope with no heavier isotopes in existance. Further, operation is conducted in a negative ion region where there is no other negatively charged species with a mass equivalent to that of C N.
What is claimed is:
l. A method of measuring carbon 14 content in a sample comprising converting carbon in said sample to CO mixing said CO with N converting said mixture of CO and N into CN ions having different masses including mass 29, separating said mass 29 CN ions from the ions having other masses, and
counting the number of mass 29 ions which have been separated from which count the concentration of carbon 14 in said sample can be determined.
2. A method as recited in claim 1 wherein said step of converting said mixture of CO and "N into CN- ions comprises introducing said mixture into a duoplasmatron negative ion source.
3. A method as recited in claim 1 wherein said CN ions having different masses including mass 29 include ions having masses 27 and 28,
said method further includes the steps of separating said ions having masses of 27 and 28 from each other, and
counting the number of ions having a mass of 27 and a mass of 28. 4. A method of determining the concentration of "C in a specimen comprising converting the carbon in said specimen to CO introducing said CO together with N into a plasma negative ion source, to form CN ions having different masses including masses 27, 28 and 29,
separating said CN ions having said different masses into separate ion beams respectively containing CN ions 27, 28 and 29, and
counting the number of ions in said separate ion beams with masses 27, 28 and 29, from which counts the concentration of C in said sample can be determined.

Claims (4)

1. A METHOD OF MEASURING CARBON 14 CONTENT IN A SAMPLE COMPRISING CONVERTING CARBON IN SAID SAMPLE TO CO2, MIXING SAID CO2 WITH 15N2, CONVERTING SAID MIXTURE OF CO2 AND 15N2 IN CN- IONS HAVING DIFFERENT MASSES INCLUDING MASS 29, SEPARATING SAID MASS 29 CN- IONS FROM THE IONS HAVING OTHER MASSES, AND CONUNTING THE NUMBER OF MASS 29 IONS WHICH HAVE BEEN SEPARATED FROM WHICH COUNT THE CONCENTRATION OF CARBON 14 IN SAID SAMPLE CAN BE DETERMINED.
2. A method as recited in claim 1 wherein said step of converting said mixture of CO2 and 15N2 into CN ions comprises introducing said mixture into a duoplasmatron negative ion source.
3. A method as recited in claim 1 wherein said CN ions having different masses including mass 29 include ions having masses 27 and 28, said method further includes the steps of separating said ions having masses of 27 and 28 from each other, and counting the number of ions having a mass of 27 and a mass of 28.
4. A method of determining the concentration of 14C in a specimen comprising converting the carbon in said specimen to CO2, introducing said CO2 together with 15N2 into a plasma negative ion source, to form CN ions having different masses including masses 27, 28 and 29, separating said CN ions having said different masses into separate ion beams respectively containing CN ions 27, 28 and 29, and counting the number of ions in said separate ion beams with masses 27, 28 and 29, from which counts the concentration of 14C in said sample can be determined.
US411801A 1973-11-01 1973-11-01 Mass spectrometric determination of carbon 14 Expired - Lifetime US3885155A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US411801A US3885155A (en) 1973-11-01 1973-11-01 Mass spectrometric determination of carbon 14

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US411801A US3885155A (en) 1973-11-01 1973-11-01 Mass spectrometric determination of carbon 14

Publications (1)

Publication Number Publication Date
US3885155A true US3885155A (en) 1975-05-20

Family

ID=23630394

Family Applications (1)

Application Number Title Priority Date Filing Date
US411801A Expired - Lifetime US3885155A (en) 1973-11-01 1973-11-01 Mass spectrometric determination of carbon 14

Country Status (1)

Country Link
US (1) US3885155A (en)

Cited By (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4866267A (en) * 1987-04-15 1989-09-12 Jeol Ltd. Double-focusing mass spectrometer having Wien filter and MS/MS instrument using such spectrometer
US5043575A (en) * 1989-02-23 1991-08-27 Finnigan Mat Gmbh Process for the mass-spectrometric investigation of isotopes, as well as isotope mass spectrometer
US5189302A (en) * 1991-10-28 1993-02-23 The United States Of America As Represented By The United States Department Of Energy Small system for tritium accelerator mass spectrometry
US20070219521A1 (en) * 2006-03-17 2007-09-20 The Procter & Gamble Company Absorbent article comprising a synthetic polymer derived from a renewable resource and methods of producing said article
WO2010090324A1 (en) 2009-02-06 2010-08-12 株式会社日本触媒 Polyacrylic acid (salt) type water-absorbent resin and process for production of same
US20110120902A1 (en) * 2011-01-25 2011-05-26 The Procter & Gamble Company Sustainable Packaging for Consumer Products
US20110166370A1 (en) * 2010-01-12 2011-07-07 Charles Winston Saunders Scattered Branched-Chain Fatty Acids And Biological Production Thereof
WO2011136237A1 (en) 2010-04-26 2011-11-03 株式会社日本触媒 Polyacrylic acid (salt), polyacrylic acid (salt)-based water-absorbing resin, and process for producing same
WO2011136238A1 (en) 2010-04-26 2011-11-03 株式会社日本触媒 Polyacrylate (salt), polyacrylate (salt) water-absorbent resin, and manufacturing method for same
WO2012058081A1 (en) 2010-10-27 2012-05-03 The Procter & Gamble Company Preparation of foam materials derived from renewable resources
WO2012112828A1 (en) 2011-02-17 2012-08-23 The Procter & Gamble Company Bio-based linear alkylphenyl sulfonates
WO2012138423A1 (en) 2011-02-17 2012-10-11 The Procter & Gamble Company Compositions comprising mixtures of c10-c13 alkylphenyl sulfonates
WO2012142271A1 (en) 2011-04-12 2012-10-18 The Procter & Gamble Company Flexible barrier packaging derived from renewable resources
WO2013023140A1 (en) 2011-08-10 2013-02-14 Metabolix, Inc. Post process purification for gamma-butyrolactone production
FR2981499A1 (en) * 2011-10-13 2013-04-19 Centre Nat Rech Scient Probe for detection of positive or negative ions for determining temperature of plasma, has section supplied with ions, where ions are deflected by electric field and directed according to charge towards respective detectors
WO2013155292A2 (en) 2012-04-11 2013-10-17 The Procter & Gamble Company Purification of bio-based acrylic acid to crude and glacial acrylic acid
WO2013155296A1 (en) 2012-04-11 2013-10-17 The Procter & Gamble Company Poly(acrylic acid) from bio-based acrylic acid and its derivatives
WO2013158477A1 (en) 2012-04-16 2013-10-24 The Procter & Gamble Company Plastic bottles for perfume compositions having improved crazing resistance
WO2013169683A1 (en) 2012-05-07 2013-11-14 The Procter & Gamble Company Flexible containers
WO2013185009A1 (en) 2012-06-08 2013-12-12 Metabolix, Inc. Renewable acrylic acid production and products made therefrom
WO2014159040A1 (en) 2013-03-12 2014-10-02 The Procter & Gamble Company Process for the conversion of methoxylated aromatic compounds to simple aromatic compounds
WO2016149091A1 (en) 2015-03-13 2016-09-22 The Procter & Gamble Company Production of terephthalic acid via reductive coupling of propiolic acid or propiolic acid derivatives
EP3178753A1 (en) 2012-08-06 2017-06-14 The Procter and Gamble Company Methods of making flexible containers
US9719037B2 (en) 2015-07-01 2017-08-01 Novomer, Inc. Methods for production of terephthalic acid from ethylene oxide
US9718755B2 (en) 2015-07-01 2017-08-01 Novomer, Inc. Methods for coproduction of terephthalic acid and styrene from ethylene oxide
WO2018170006A1 (en) 2017-03-17 2018-09-20 Novomer Inc. Polyamides, and methods of producing thereof
WO2019006366A1 (en) 2017-06-30 2019-01-03 Novomer, Inc. Process for the preparation of organic acids from beta lactones
WO2019006377A1 (en) 2017-06-30 2019-01-03 Novomer, Inc. Compositions for improved production of acrylic acid
CN109696337A (en) * 2017-10-24 2019-04-30 中国石油化工股份有限公司 A kind of solid oxidizer and its preparation method and application
WO2019195168A1 (en) 2018-04-06 2019-10-10 Novomer, Inc. Polypropiolactone films, and methods of producing thereof
WO2020005951A1 (en) 2018-06-29 2020-01-02 Novomer, Inc. Systems and processes for producing organic acids directly from beta-lactones
WO2020014466A1 (en) 2018-07-13 2020-01-16 Novomer, Inc. Polylactone foams and methods of making the same
WO2020028606A1 (en) 2018-08-02 2020-02-06 Saudi Aramco Technologies Company Sustainable polymer compositions and methods
US10590099B1 (en) 2017-08-10 2020-03-17 Novomer, Inc. Processes for producing beta-lactone with heterogenous catalysts
US10597294B2 (en) 2014-05-30 2020-03-24 Novomer, Inc. Integrated methods for chemical synthesis
US10662139B2 (en) 2016-03-21 2020-05-26 Novomer, Inc. Acrylic acid production process
US10676426B2 (en) 2017-06-30 2020-06-09 Novomer, Inc. Acrylonitrile derivatives from epoxide and carbon monoxide reagents
US10703702B2 (en) 2015-07-31 2020-07-07 Novomer, Inc. Production system/production process for acrylic acid and precursors thereof
WO2020185420A1 (en) 2019-03-08 2020-09-17 Novomer, Inc. Integrated methods and systems for producing amide and nitrile compounds
WO2021025918A2 (en) 2019-08-02 2021-02-11 Novomer, Inc. Heterogeneous catalysts, and uses thereof
US10961209B2 (en) 2017-08-10 2021-03-30 Novomer, Inc. Processes for producing beta-lactone and beta-lactone derivatives with heterogenous catalysts
US11078172B2 (en) 2015-02-13 2021-08-03 Novomer, Inc. Integrated methods for chemical synthesis
US11685809B2 (en) 2018-03-22 2023-06-27 Novomer, Inc. Phosphorus-containing polymers, and methods of producing thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3786249A (en) * 1971-12-20 1974-01-15 Stanford Research Inst Negative ion duoplasmatron mass spectrometer for isotope ratio analysis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3786249A (en) * 1971-12-20 1974-01-15 Stanford Research Inst Negative ion duoplasmatron mass spectrometer for isotope ratio analysis

Cited By (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4866267A (en) * 1987-04-15 1989-09-12 Jeol Ltd. Double-focusing mass spectrometer having Wien filter and MS/MS instrument using such spectrometer
US5043575A (en) * 1989-02-23 1991-08-27 Finnigan Mat Gmbh Process for the mass-spectrometric investigation of isotopes, as well as isotope mass spectrometer
US5189302A (en) * 1991-10-28 1993-02-23 The United States Of America As Represented By The United States Department Of Energy Small system for tritium accelerator mass spectrometry
US10920407B2 (en) 2006-03-17 2021-02-16 The Procter & Gamble Company Absorbent article comprising a synthetic polymer derived from a renewable resource and methods of producing said article
US10501920B2 (en) 2006-03-17 2019-12-10 The Procter & Gamble Company Absorbent article comprising a synthetic polymer derived from a renewable resource and methods of producing said article
US10166312B2 (en) 2006-03-17 2019-01-01 The Procter & Gamble Company Absorbent article comprising a synthetic polymer derived from a renewable resource and methods of producing said article
US20110139662A1 (en) * 2006-03-17 2011-06-16 Bryn Hird Absorbent Article Comprising A Synthetic Polymer Derived From A Renewable Resource And Methods Of Producing Said Article
US20110139658A1 (en) * 2006-03-17 2011-06-16 Bryn Hird Absorbent Article Comprising A Synthetic Polymer Derived From A Renewable Resource And Methods Of Producing Said Article
US20110152812A1 (en) * 2006-03-17 2011-06-23 Bryn Hird Absorbent Article Comprising A Synthetic Polymer Derived From A Renewable Resource And Methods Of Producing Said Article
US10815653B2 (en) 2006-03-17 2020-10-27 The Procter & Gamble Company Absorbent article comprising a synthetic polymer derived from a renewable resource and methods of producing said article
US12054928B2 (en) 2006-03-17 2024-08-06 The Procter & Gamble Company Absorbent article comprising a synthetic polymer derived from a renewable resource and methods of producing said article
US10822783B2 (en) 2006-03-17 2020-11-03 The Proctor & Gamble Company Absorbent article comprising a synthetic polymer derived from a renewable resource and methods of producing said article
US11186976B2 (en) 2006-03-17 2021-11-30 The Procter & Gamble Company Absorbent article comprising a synthetic polymer derived from a renewable resource and methods of producing said article
US20070219521A1 (en) * 2006-03-17 2007-09-20 The Procter & Gamble Company Absorbent article comprising a synthetic polymer derived from a renewable resource and methods of producing said article
US9518133B2 (en) 2009-02-06 2016-12-13 Nippon Shokubai Co., Ltd. Hydrophilic polyacrylic acid (salt) resin and manufacturing method thereof
US8648161B2 (en) 2009-02-06 2014-02-11 Nippon Shokubai Co., Ltd. Polyacrylic acid (salt) -based water-absorbent resin and a method for producing it
WO2010090324A1 (en) 2009-02-06 2010-08-12 株式会社日本触媒 Polyacrylic acid (salt) type water-absorbent resin and process for production of same
US20110171155A1 (en) * 2010-01-12 2011-07-14 Thomas Walter Federle Intermediates And Surfactants useful In Household Cleaning And Personal Care Compositions, And Methods Of Making The Same
US20110166370A1 (en) * 2010-01-12 2011-07-07 Charles Winston Saunders Scattered Branched-Chain Fatty Acids And Biological Production Thereof
WO2011088089A1 (en) 2010-01-12 2011-07-21 The Procter & Gamble Company Intermediates and surfactants useful in household cleaning and personal care compositions, and methods of making the same
US8933131B2 (en) 2010-01-12 2015-01-13 The Procter & Gamble Company Intermediates and surfactants useful in household cleaning and personal care compositions, and methods of making the same
WO2011136237A1 (en) 2010-04-26 2011-11-03 株式会社日本触媒 Polyacrylic acid (salt), polyacrylic acid (salt)-based water-absorbing resin, and process for producing same
WO2011136238A1 (en) 2010-04-26 2011-11-03 株式会社日本触媒 Polyacrylate (salt), polyacrylate (salt) water-absorbent resin, and manufacturing method for same
WO2012058081A1 (en) 2010-10-27 2012-05-03 The Procter & Gamble Company Preparation of foam materials derived from renewable resources
WO2012102778A1 (en) 2011-01-25 2012-08-02 The Procter & Gamble Company Sustainable packaging for consumer products
US20110120902A1 (en) * 2011-01-25 2011-05-26 The Procter & Gamble Company Sustainable Packaging for Consumer Products
US8083064B2 (en) 2011-01-25 2011-12-27 The Procter & Gamble Company Sustainable packaging for consumer products
WO2012112828A1 (en) 2011-02-17 2012-08-23 The Procter & Gamble Company Bio-based linear alkylphenyl sulfonates
WO2012138423A1 (en) 2011-02-17 2012-10-11 The Procter & Gamble Company Compositions comprising mixtures of c10-c13 alkylphenyl sulfonates
US9193937B2 (en) 2011-02-17 2015-11-24 The Procter & Gamble Company Mixtures of C10-C13 alkylphenyl sulfonates
WO2012142271A1 (en) 2011-04-12 2012-10-18 The Procter & Gamble Company Flexible barrier packaging derived from renewable resources
WO2013023140A1 (en) 2011-08-10 2013-02-14 Metabolix, Inc. Post process purification for gamma-butyrolactone production
FR2981499A1 (en) * 2011-10-13 2013-04-19 Centre Nat Rech Scient Probe for detection of positive or negative ions for determining temperature of plasma, has section supplied with ions, where ions are deflected by electric field and directed according to charge towards respective detectors
WO2013155292A2 (en) 2012-04-11 2013-10-17 The Procter & Gamble Company Purification of bio-based acrylic acid to crude and glacial acrylic acid
WO2013155296A1 (en) 2012-04-11 2013-10-17 The Procter & Gamble Company Poly(acrylic acid) from bio-based acrylic acid and its derivatives
US9622563B2 (en) 2012-04-16 2017-04-18 The Procter & Gamble Company Plastic packages for dispensing aerosol products having improved crazing resistance and sustainability
WO2013158477A1 (en) 2012-04-16 2013-10-24 The Procter & Gamble Company Plastic bottles for perfume compositions having improved crazing resistance
WO2013169682A1 (en) 2012-05-07 2013-11-14 The Procter & Gamble Company Flexible containers
WO2013169683A1 (en) 2012-05-07 2013-11-14 The Procter & Gamble Company Flexible containers
WO2013169684A1 (en) 2012-05-07 2013-11-14 The Procter & Gamble Company Flexible containers having a decoration panel
WO2013169681A1 (en) 2012-05-07 2013-11-14 The Procter & Gamble Company Flexible containers
WO2013185009A1 (en) 2012-06-08 2013-12-12 Metabolix, Inc. Renewable acrylic acid production and products made therefrom
EP3178753A1 (en) 2012-08-06 2017-06-14 The Procter and Gamble Company Methods of making flexible containers
US9452422B2 (en) 2013-03-12 2016-09-27 The Procter & Gamble Company Catalysts and processes for the production of aromatic compounds from lignin
WO2014159040A1 (en) 2013-03-12 2014-10-02 The Procter & Gamble Company Process for the conversion of methoxylated aromatic compounds to simple aromatic compounds
US10829372B2 (en) 2014-05-30 2020-11-10 Novomer, Inc. Integrated methods for chemical synthesis
US10597294B2 (en) 2014-05-30 2020-03-24 Novomer, Inc. Integrated methods for chemical synthesis
US11078172B2 (en) 2015-02-13 2021-08-03 Novomer, Inc. Integrated methods for chemical synthesis
US11807613B2 (en) 2015-02-13 2023-11-07 Novomer, Inc. Integrated methods for chemical synthesis
WO2016149091A1 (en) 2015-03-13 2016-09-22 The Procter & Gamble Company Production of terephthalic acid via reductive coupling of propiolic acid or propiolic acid derivatives
US9719037B2 (en) 2015-07-01 2017-08-01 Novomer, Inc. Methods for production of terephthalic acid from ethylene oxide
US9718755B2 (en) 2015-07-01 2017-08-01 Novomer, Inc. Methods for coproduction of terephthalic acid and styrene from ethylene oxide
US10703702B2 (en) 2015-07-31 2020-07-07 Novomer, Inc. Production system/production process for acrylic acid and precursors thereof
US10662139B2 (en) 2016-03-21 2020-05-26 Novomer, Inc. Acrylic acid production process
US11718714B2 (en) 2017-03-17 2023-08-08 Novomer, Inc. Polyamides, and methods of producing thereof
WO2018170006A1 (en) 2017-03-17 2018-09-20 Novomer Inc. Polyamides, and methods of producing thereof
US10676426B2 (en) 2017-06-30 2020-06-09 Novomer, Inc. Acrylonitrile derivatives from epoxide and carbon monoxide reagents
WO2019006377A1 (en) 2017-06-30 2019-01-03 Novomer, Inc. Compositions for improved production of acrylic acid
WO2019006366A1 (en) 2017-06-30 2019-01-03 Novomer, Inc. Process for the preparation of organic acids from beta lactones
US10590099B1 (en) 2017-08-10 2020-03-17 Novomer, Inc. Processes for producing beta-lactone with heterogenous catalysts
US10961209B2 (en) 2017-08-10 2021-03-30 Novomer, Inc. Processes for producing beta-lactone and beta-lactone derivatives with heterogenous catalysts
CN109696337B (en) * 2017-10-24 2022-03-29 中国石油化工股份有限公司 Solid oxidant and preparation method and application thereof
CN109696337A (en) * 2017-10-24 2019-04-30 中国石油化工股份有限公司 A kind of solid oxidizer and its preparation method and application
US11685809B2 (en) 2018-03-22 2023-06-27 Novomer, Inc. Phosphorus-containing polymers, and methods of producing thereof
WO2019195168A1 (en) 2018-04-06 2019-10-10 Novomer, Inc. Polypropiolactone films, and methods of producing thereof
WO2020005951A1 (en) 2018-06-29 2020-01-02 Novomer, Inc. Systems and processes for producing organic acids directly from beta-lactones
WO2020014466A1 (en) 2018-07-13 2020-01-16 Novomer, Inc. Polylactone foams and methods of making the same
WO2020028606A1 (en) 2018-08-02 2020-02-06 Saudi Aramco Technologies Company Sustainable polymer compositions and methods
US11498894B2 (en) 2019-03-08 2022-11-15 Novomer, Inc. Integrated methods and systems for producing amide and nitrile compounds
WO2020185420A1 (en) 2019-03-08 2020-09-17 Novomer, Inc. Integrated methods and systems for producing amide and nitrile compounds
WO2021025918A2 (en) 2019-08-02 2021-02-11 Novomer, Inc. Heterogeneous catalysts, and uses thereof

Similar Documents

Publication Publication Date Title
US3885155A (en) Mass spectrometric determination of carbon 14
Macfarlane et al. 252Cf-plasma desorption time-of-flight mass spectrometry
EP0721655B1 (en) An ultra-sensitive molecular identifier
US20090114809A1 (en) Isotope ratio mass spectrometer and methods for determining isotope ratios
Wiley Bendix time-of-flight mass spectrometer
US5545894A (en) Compact hydrogen/helium isotope mass spectrometer
Haddon et al. Metastable ion characteristics. Measurements with a modified time-of-flight mass spectrometer
Dong et al. The new AMS facility at Tianjin University
Moran et al. Charge neutralization of He+ ion beams
Tsong et al. Methods for a precision measurement of ionic masses and appearance energies using the pulsed‐laser time‐of‐flight atom probe
Inghram Modern mass spectroscopy
Woelfli et al. Radioisotope dating with the ETHZ-EN-tandem accelerator
McLafferty High-Resolution Mass Spectrometry: Elemental composition and structural parts of a molecule are indicated from a submicrogram sample.
Nier The development of a high resolution mass spectrometer: a reminiscence
Betti et al. Isotopic abundance measurements on solid nuclear-type samples by glow discharge mass spectrometry
US5569915A (en) Sensitive mass spectroscopy using molecular fragmentation
US2999157A (en) Method and apparatus for ionization investigation
Greenwood et al. State-selective one-electron capture from He, Ne and Ar by 4 keV state-prepared ions
Anbar Mass spectrometric determination carbon 14
Feser et al. The quadrupole mass filter for GC/MS applications
Litherland et al. Ultra-sensitive mass spectrometry with tandem accelerators
CN113156032A (en) Mass spectrum system and method for simultaneously measuring isotope abundance and impurity content
Beynon et al. Ion kinetic energy spectrometry
Huq et al. Measurements of absolute total cross sections for charge transfer and electron detachment of halide ions on chlorine
Dibeler et al. Mass-spectrometer study of the rare gases