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Expandable drug delivery device

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Publication number
US3865108A
US3865108A US37735073A US3865108A US 3865108 A US3865108 A US 3865108A US 37735073 A US37735073 A US 37735073A US 3865108 A US3865108 A US 3865108A
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Prior art keywords
device
base
medicament
containing
fig
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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William L Hartop
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Ortho Pharmaceutical Corp
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Ortho Pharmaceutical Corp
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0039Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time

Abstract

A drug delivery device having a drug containing zone associated with and partially defined by a material which swells on contact with body fluids. When swelling occurs, the pressure on the drug containing zone expels the drug from the device.

Description

111111661 @tates Fatent 1 1 [111 gamma Marion 1 Feb. 11, 1975 1 1 EXPANDABLE DRUG DIEUVERY DEVICE 2.6431027 6/1953 2.687.729 8/1965 [75] Inventor: William L. Hartop, Bernardsvtlle, 2959250 H960 NJ. 3,102.540 9/1963 3.202.324 8/1965 [73] Assignee. ggliitgrlllhrjrjnaceutical Corporation, 3'490454 H1970 3.559.646 2/1971 [22] Filed: July 9, 1973 3,760,805 973 3.760.984 9/1973 Theeuwes 128/260 X [21] Appl. No.: 377,350

Related Application Data Primary Examiner-Richard A. Gaudet [63] Continuation-impart of Ser. No. 144,174, May 17. Assistant Examiner-J. C. McGowan 1971. flbandoned- Attorney, Agent, or Firm-Benjamin F. Lambert 152] 11.5. C1 128/260, 128/270, 222/95 [51] int. CI A6111 31/00 [57 ABSTRACT [511] Field of Search 128/260, 127, 130. 268,

128/215, 216, 253, 213, 2 W, 2 R, 1 R, 329, A drug delivery device having a drug containing zone 330, 333, 314, 315, 270, 271, 285; 222/92, associated with and partially defined by a material 95, 206, 103, 105 which swells on contact with body fluids. When swelling occurs, the pressure on the drug containing zone (56] References Cited expels the drug from the device.

UNlTED STATES PATENTS 10 Cl 14 D F 706,778 8/1902 Pond 128/270 rawmg gums PATENIED FEB] 1 I975 SHEET 10F 2 INVENTOR Maw/n4. hM/QTOP BY mm, (1 Mg ATTORNEY I EXPANDABILE DRUG DELIVERY DEVICE This is a continuation-in-part of co-pending application Ser. No. 144,174 filed May 17,-1971, now abandoned.

Current methods of introducing medicaments such as prostaglandins, for example, into the uterine cavity for the purpose of abortion and the like require the use of in-dwelling catheters and the continual attention of medical personnel to deliver the drug by use of a syringe or by hydrostatic pressure from an outside reservoir. The device of this invention obviates the need for an indwelling catheter and, more. importantly, eliminates the need for an operator to monitor the administration of the drug.

The device of this invention comprises a generally cylindrical or prismatic base incorporating a substance which swells upon contact with natural body fluids. The base of the device either defines a hollow core containing a medicament or has disposed in a relatively restrained position around or adjacent its outer surface a medicament containing tube or sheath. In other words, the base at least partially defines a medicament containing zone of restricted dimensions. In either case, the medicament is dispensed into the body cavity due to the pressure generated on the medicament containing zone by virtue of the swelling of the base.

The invention may be better understood by reference to the attached drawings, wherein FIG. 1 is a longitudinal cross-section of a device of this invention;

FIG. 2 is a vertical cross-section of the device of FIG. 1 taken along lines 22;

FIG. 3 is a longitudinal cross-section of the device of FIGS. 1 and 2 after use;

FIG. 4 is a vertical cross-section of the used device of FIG. 3 taken along lines 4--4;

FIG. 5 is a longitudinal cross-section of another de vice of this invention;

FIG. 6 is a vertical cross-section of the device of FIG. 5 taken along lines 6-6;

FIG. 7 is a vertical cross-section of still another device of this invention illustrating the same both before and after exposure;

FIG. 8 also is a vertical cross-section of another device of this invention illustrating the same both before and after exposure;

FIG. 9 is a vertical cross-section of yet another device of this invention illustrating the same both before and after exposure;

FIG. 10 is a view in perspective of still another device of this invention;

FIG. 11 is a cross-section of the device of FIG. 10 taken along lines Ill-I1;

FIG. 12 is a vertical cross-section of another device of this invention;

FIG. 13 is a top view of another device of this invention;

FIG. 14 is a top view of yet another device of this invention.

FIGS. 1 through 11 illustrate embodiments of the invention wherein the base of the device defines a hollow medicament filled core. The device of FIGS. 1 and 2 consists ofa base, 1, formed of a material which will expand multi-directionally upon contact with body fluids, the base defining a hollow core, 2. The hollow core, 2, contains a medicament. 3, which is encased in a col- 2 lapsible tube, 4, having a closed end, 5,,projecting outward from the end, 6, of the base, I. When in use, the end of the collapsible tube is severed and the device inserted into a body cavity such as the cervix. The base, 1, will expand multi-directionally upon contact with body fluid and the resistance to expansion offered by the cervix causes the tube to collapse andthe medicament to be dispensed into the body cavity. The cervical canal is gradually enlarged to accommodate thev increased dimensions. Thus, when used to dispense a medicament for the termination of pregnancy, for example, the dilation of the cervix will facilitate the abortion.

FIGS. 3 and 4 illustrate the device of FIGS. I and 2 after use. In FIGS. 3 and 4, the capillary tube, 4, has been compressed and its contents have been expelled into the uterine cavity.

While the device may be of any shape, it is preferred that it be prismatic or cylindrical for enhancing comfort and facilitating insertion. The device also preferably has a tail, 7, to assist in its removal after use. It may also be advantageous to mold the base of the device with an enlarged end portion, 8, to prevent the device from accidentally being inserted completely into the uterus. It is not practical to give a particular dimension for the device since the size employed will depend upon whether the device is used in the nostrils, vagina, for treating rectal disorders, etc.

The base of the device is made either primarily of a material which will itself expand upon contact with body fluids, or is made of an expandable material having incorporated therein a substance which will expand upon contact with body fluids. By expandable material is meant a material which will swell or expand beyond its original or normal limits. Examples of such expandable materials include brown algae, in particular species of the genus Laminaria; polysaccharides derived from brown and red seaweeds, such as alkali metal and ammonium salts of alginic acids and carrageenan; biosynthetic polysaccharides such as xanthan gum; natural gums, such as guar gum, karaya, tragacanth, psyllium seed, and locust bean; cellulose derivatives such as microcrystallinecellulose; synthetic resins derived from cellulose, such as carboxymethylcellulose, and nonionic cellulose gums such as methylcellulose and hydroxypropyl cellulose; synthetic water-absorbing polymers such as polyvinyl alcohol, polyacrylamide, polyvinylpyrrolidone, and ethylene oxide polymers; and modified starches such as pre-gelatinized corn starch. Preferred among the expandable materials are those derived from brown algae and in particular those derived from species of the genus Laminaria.

In practice, the capillary tube may be constructed of any thin, easily collapsible metal or plastic material such as aluminum or Teflon. The material must have sufficient strength to protect the medicament during storage prior to use, but at the time of use must be eas- -ily severable and collapsible. The collapsible tube, and

the hollow core, preferably have an oval cross-section to facilitate collapse under pressure; however, any convenient shape may be utilized.

In some cases, it may be desirable to encase the base in an outer skin of highly flexible water-permeable material, 9a, such as is illustrated in FIGS. 5 and 6. Such a skin assures that the device will not break apart upon softening and swelling when in contact with body fluids. It may be advantageous to form such a skin ofa material having a high modulus of elasticity so as to exert added pressure on the medicament containing zone as the base attempts to expand.

It is possible to further improve the operation of the device by modifying the collapsible tube to prevent entrapment of the drug-due to irregular collapse of segments of the tube. Irregular collapse can be avoided by molding a longitudinal 'rib, b, inside the tube as shown in FIG. 7. Thus, the rib will allow passage of a medicament on either side of it after the tube has collapsed. This may also be accomplished by disposing ribs, 100, at each side of the tube as shown in FIG. 8. Irregular collapse may also be overcome by providing a tube with a rectangular cross-section of appropriate stiffness so that the short side walls, 11d, tend to resist collapse and thus permit passage of the drug through the spaces adjacent them as illustrated in FIG. 9.

While it was indicated at the outset that the device is preferably cylindrical or prismatic, this does not mean that the base must be formed of only one such solid. As illustrated in FIG. 10, the base may be of any shape as long as it has smooth sides and corners, and defines a hollow core into which the medicament or a capillary containing the medicament may be inserted. The device of FIG. 10 consists of a series of four rods, 101, of a material which swells when in contact with body fluids, arranged in a bundle so as to leave an open core, 102, sufficient to hold a small capillary, 104, containing the active drug, 103. The rods may be kept in their illustrated configuration by an outer water-permeable covering, 109, such as the type previously described. The expansion of the rods will fill the void occupied by the capillary and thus extrude the contents into the body cavity.

A particularly adaptable substance for a device of this design is the stalk of the seaweed of the Laminaria family which, when dried, becomes rigid and bone-like. When exposed to water, the stalk will increase in diameter nearly three-fold and become soft and flexible.

As an example of the device illustrated in FIGS. 10 and ll, and the manner in which it functions, four rods of Laminaria, each about 2V2 inches long and about A; of an inch in diameter are bound firmly together by means of fine copper wire. A catheter having an inside diameter of 0.025 inches and an outside diameter of 0.047 inches is inserted longitudinally through the space between the rods, is filled with a vegetable dye solution and one end is clamped off. When the device is immersed in water, within 12 minutes the dye solution can be observed issuing from the open end of the catheter. The dye continues to be expelled very slowly at what appears to be a uniform rate for a total of one hour and minutes. Calculations indicate that the rate of expulsion of the dye cannot have exceeded 1 X l0 ml. per minute. This rate conforms to the concept of the delivery of very small doses of highly active medicaments in a continuous fashion.

FIGS. 12 through 14 illustrate embodiments of the invention wherein the base of the device has a medicament containing tube or sheath disposed in a relatively restrained position around or adjacent its outer surface. Referring specifically to FIG. 12, the base, 201, of the device illustrated constitutes a solid core surrounded by medicament, 203, encased in a sheath,.209. The sheath is not permeable to fluids but the base absorbs body fluids through its ends thus causing the desired effect.

Referring to FIG. 13, the medicament containing tube, 304, of the device illustrated therein is helically wound around the base, 301, and anchored by passing it through the base at either end, 310. As the base expands, medicament is delivered through one of the ends, 310.

Finally, referring to FIG. 14, the medicament containing tube, 404, of the device illustrated therein is secured adjacent to the surface of the base, 401, by pass ing the same through the base at either end, 410. As the base expands, medicament is delivered through one of the ends, 410.

What is claimed is:

l. A device for the delivery of a medicament to a body cavity comprising a base, said base at least partially defining a medicament containing zone of restricted dimensions, said base being expandable and incorporating a material which expands sufficiently upon contact with body fluids to expand said base, said material being selected from the group consisting of brown algae, polysaccharides derived from brown and red seaweeds, biosynthetic polysaccharides, natural gums, cellulose derivatives, synthetic resins derived from cellulose, polyacrylamide, polyvinylpyrrolidone, ethylene oxide polymers, and modified starches, and said medicament containing zone being disposed in pressure responsive relation to said expandable base such that upon insertion of the device into a body cavity pressure is exerted on the medicament containing zone as a result of resistance to expansion by the base within the body cavity which causes the base to compress the medicament containing zone resulting in the medicament contained therein being dispensed into the body cavity.

2. The device of claim 1 wherein said base is comprised of a polymeric material and defines a hollow core which constitutes said medicament containing zone. I,

3. The device of claim 1 wherein said expandable material is Laminaria.

4. The device of claim 2 wherein said core contains a collapsible capillary tube containing said medicament.

5. The device of claim 4 in which said capillary is of oval cross-section.

6. The device of claim 1 in which a collapsible capillary tube containing said medicament is disposed in fixed position adjacent the surface of said base and the peripheral surface of said tube defining an annular medicament containing zone.

7. The device of claim 4 in which said capillary contains an inner rib along substantially its entire length.

8. The device of claim 4 in which the capillary contains a plurality of inner ribs along substantially its entire length.

9. The device of claim 4 in which the capillary tube is of rectangular cross-section.

10. The device of claim 6 in which said capillary contains an inner rib along substantially its entire length.

Claims (10)

1. A device for the delivery of a medicament to a body cavity comprising a base, said base at least paRtially defining a medicament containing zone of restricted dimensions, said base being expandable and incorporating a material which expands sufficiently upon contact with body fluids to expand said base, said material being selected from the group consisting of brown algae, polysaccharides derived from brown and red seaweeds, biosynthetic polysaccharides, natural gums, cellulose derivatives, synthetic resins derived from cellulose, polyacrylamide, polyvinylpyrrolidone, ethylene oxide polymers, and modified starches, and said medicament containing zone being disposed in pressure responsive relation to said expandable base such that upon insertion of the device into a body cavity pressure is exerted on the medicament containing zone as a result of resistance to expansion by the base within the body cavity which causes the base to compress the medicament containing zone resulting in the medicament contained therein being dispensed into the body cavity.
2. The device of claim 1 wherein said base is comprised of a polymeric material and defines a hollow core which constitutes said medicament containing zone.
3. The device of claim 1 wherein said expandable material is Laminaria.
4. The device of claim 2 wherein said core contains a collapsible capillary tube containing said medicament.
5. The device of claim 4 in which said capillary is of oval cross-section.
6. The device of claim 1 in which a collapsible capillary tube containing said medicament is disposed in fixed position adjacent the surface of said base and the peripheral surface of said tube defining an annular medicament containing zone.
7. The device of claim 4 in which said capillary contains an inner rib along substantially its entire length.
8. The device of claim 4 in which the capillary contains a plurality of inner ribs along substantially its entire length.
9. The device of claim 4 in which the capillary tube is of rectangular cross-section.
10. The device of claim 6 in which said capillary contains an inner rib along substantially its entire length.
US3865108A 1971-05-17 1973-07-09 Expandable drug delivery device Expired - Lifetime US3865108A (en)

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Cited By (200)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3946734A (en) * 1975-02-19 1976-03-30 The United States Of America As Represented By The Secretary Of State Apparatus for controlling the release of a drug
US4005699A (en) * 1974-10-09 1977-02-01 Louis Bucalo Methods and apparatus for use in magnetic treatment of the body
US4041948A (en) * 1976-07-26 1977-08-16 Johnson & Johnson Digital tampon
US4185618A (en) * 1976-01-05 1980-01-29 Population Research, Inc. Promotion of fibrous tissue growth in fallopian tubes for female sterilization
US4192308A (en) * 1977-10-25 1980-03-11 Alza Corporation Device using prestretched polymer for dispensing medication
US4203440A (en) * 1978-10-23 1980-05-20 Alza Corporation Device having variable volume chamber for dispensing useful agent
US4207893A (en) * 1977-08-29 1980-06-17 Alza Corporation Device using hydrophilic polymer for delivering drug to biological environment
US4237893A (en) * 1979-11-28 1980-12-09 Alza Corporation Cervical dilator
US4299222A (en) * 1980-01-08 1981-11-10 Alza Corporation Self-contained suction pump
US4304232A (en) * 1979-03-14 1981-12-08 Alza Corporation Unit system having multiplicity of means for dispensing useful agent
US4350271A (en) * 1980-08-22 1982-09-21 Alza Corporation Water absorbing fluid dispenser
US4360013A (en) * 1980-04-21 1982-11-23 Minnesota Mining And Manufacturing Company Polymeric acid contraceptive devices
US4367741A (en) * 1980-12-22 1983-01-11 Alza Corporation Dispenser powered by cross-linked hydrophilic polymer grafted to hydrophilic polymer
WO1984000494A1 (en) * 1982-07-26 1984-02-16 Health Prod Res Dilatation device for the cervix
US4455144A (en) * 1980-12-04 1984-06-19 Alza Corporation Dispenser constructed with semipermeable polymer-hydrophilic polymer wall
FR2561628A1 (en) * 1984-03-21 1985-09-27 Alza Corp An intake of substances multicomponent operating in unitary integrated system
EP0168507A1 (en) * 1981-04-27 1986-01-22 Repromed, Inc. Osmotic cervical dilator
US4663149A (en) * 1984-03-21 1987-05-05 Alza Corporation Dispenser comprising inner and outer walls functioning as cooperative unit
US4663148A (en) * 1984-03-21 1987-05-05 Alza Corporation Dispenser comprising telescopically engaging members
US4692326A (en) * 1984-03-21 1987-09-08 Alza Corporation Dispenser comprising inner positioned soft or hard capsule
US4716031A (en) * 1984-03-21 1987-12-29 Alza Corporation Drug dispenser comprising a multiplicity of members acting together for successfully dispensing drug
DE3634864A1 (en) * 1983-11-02 1988-04-14 Alza Corp Delivery device for release of a temperature-responsive mass
US4764380A (en) * 1982-03-22 1988-08-16 Alza Corporation Drug delivery system comprising a volume increasing matrix containing a plurality of tiny pills
US4778607A (en) * 1984-04-30 1988-10-18 Marathon Oil Company Method of diluting a concentrated polymer solution for use in a hydrocarbon recovery process
US4800056A (en) * 1984-03-21 1989-01-24 Alza Corporation Process for making dispenser with cooperating elements
US4814180A (en) * 1984-03-21 1989-03-21 Alza Corporation Agent dispenser comprising a semipermeable wall surrounding single-piece or two-piece container
US4846279A (en) * 1988-01-13 1989-07-11 Marathon Oil Company Method and means for introducing treatment fluid into a well bore
US4851232A (en) * 1987-02-13 1989-07-25 Alza Corporation Drug delivery system with means for obtaining desirable in vivo release rate pattern
US4855141A (en) * 1988-03-25 1989-08-08 Alza Corporation Device comprising means for protecting and dispensing fluid sensitive medicament
US4871542A (en) * 1987-04-30 1989-10-03 Ferring Service Center, N.V. Method and apparatus useful for delivering medicinal compositions into the bladder and urinary tract
US4931285A (en) * 1988-04-28 1990-06-05 Alza Corporation Aqueous based pharmaceutical coating composition for dosage forms
US4959218A (en) * 1988-03-25 1990-09-25 Alza Corporation Method for delivering somatotropin to an animal
US4976966A (en) * 1988-12-29 1990-12-11 Alza Corporation Delayed release osmotically driven fluid dispenser
US4996060A (en) * 1988-03-25 1991-02-26 Alza Corporation Device comprising liner for protecting fluid sensitive medicament
US5006346A (en) * 1988-04-28 1991-04-09 Alza Corporation Delivery system
US5019397A (en) * 1988-04-21 1991-05-28 Alza Corporation Aqueous emulsion for pharmaceutical dosage form
US5024842A (en) * 1988-04-28 1991-06-18 Alza Corporation Annealed coats
US5024663A (en) * 1990-02-21 1991-06-18 Alza Corporation Self-contained suction pump
US5034229A (en) * 1988-12-13 1991-07-23 Alza Corporation Dispenser for increasing feed conversion of hog
US5035897A (en) * 1989-09-05 1991-07-30 Alza Corporation Dosage form for delivering soluble or insoluble drugs
US5037420A (en) * 1988-12-13 1991-08-06 Alza Corporation Delivery system comprising two sections for delivering somatotropin
US5057318A (en) * 1988-12-13 1991-10-15 Alza Corporation Delivery system for beneficial agent over a broad range of rates
US5059423A (en) * 1988-12-13 1991-10-22 Alza Corporation Delivery system comprising biocompatible beneficial agent formulation
US5110596A (en) * 1988-12-13 1992-05-05 Alza Corporation Delivery system comprising means for delivering agent to livestock
US5126142A (en) * 1989-07-18 1992-06-30 Alza Corporation Dispenser comprising ionophore
US5135523A (en) * 1988-12-13 1992-08-04 Alza Corporation Delivery system for administering agent to ruminants and swine
US5137727A (en) * 1991-06-12 1992-08-11 Alza Corporation Delivery device providing beneficial agent stability
US5160743A (en) * 1988-04-28 1992-11-03 Alza Corporation Annealed composition for pharmaceutically acceptable drug
US5174999A (en) * 1988-12-13 1992-12-29 Alza Corporation Delivery system comprising fluid ingress and drug egress
US5180591A (en) * 1990-07-11 1993-01-19 Alza Corporation Delivery device with a protective sleeve
US5198229A (en) * 1991-06-05 1993-03-30 Alza Corporation Self-retaining gastrointestinal delivery device
US5223265A (en) * 1992-01-10 1993-06-29 Alza Corporation Osmotic device with delayed activation of drug delivery
US5234692A (en) * 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5234694A (en) * 1990-07-11 1993-08-10 Alza Corporation Method for increasing feed efficiency in animals
US5234693A (en) * 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5236689A (en) * 1987-06-25 1993-08-17 Alza Corporation Multi-unit delivery system
US5238687A (en) * 1990-07-11 1993-08-24 Alza Corporation Delivery device with a protective sleeve
US5240713A (en) * 1991-09-27 1993-08-31 Alza Corporation Dual rate agent delivery device
US5273752A (en) * 1989-07-18 1993-12-28 Alza Corporation Controlled release dispenser comprising beneficial agent
US5282785A (en) * 1990-06-15 1994-02-01 Cortrak Medical, Inc. Drug delivery apparatus and method
US5340590A (en) * 1987-06-25 1994-08-23 Alza Corporation Delivery system with bilayer osmotic engine
US5391381A (en) * 1987-06-25 1995-02-21 Alza Corporation Dispenser capable of delivering plurality of drug units
US5443459A (en) * 1991-01-30 1995-08-22 Alza Corporation Osmotic device for delayed delivery of agent
US5458568A (en) * 1991-05-24 1995-10-17 Cortrak Medical, Inc. Porous balloon for selective dilatation and drug delivery
US5474785A (en) * 1990-01-24 1995-12-12 Alza Corporation Delivery system comprising means for controlling internal pressure
US5498255A (en) * 1993-08-17 1996-03-12 Alza Corporation Osmotic device for protracted pulsatile delivery of agent
US5498238A (en) * 1990-06-15 1996-03-12 Cortrak Medical, Inc. Simultaneous angioplasty and phoretic drug delivery
US5536243A (en) * 1994-12-13 1996-07-16 Jeyendran; Rajasingam S. Time-release insemination device
US5690952A (en) * 1995-06-07 1997-11-25 Judy A. Magruder et al. Implantable system for delivery of fluid-sensitive agents to animals
US5707663A (en) * 1993-05-28 1998-01-13 Alza Corporation Sustained antiepileptic therapy
US5728088A (en) * 1988-12-13 1998-03-17 Alza Corporation Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals
US5773020A (en) * 1990-04-25 1998-06-30 Vivus, Inc. Treatment of erectile dysfunction
US5800422A (en) * 1995-06-02 1998-09-01 Alza Corporation Osmotic device with delayed activation of drug delivery and complete drug release
US5807306A (en) * 1992-11-09 1998-09-15 Cortrak Medical, Inc. Polymer matrix drug delivery apparatus
US5817335A (en) * 1995-05-26 1998-10-06 Alza Corporation Osmotic device with high drug loading and delayed activation of drug delivery
US5861166A (en) * 1991-03-12 1999-01-19 Alza Corporation Delivery device providing beneficial agent stability
US5902605A (en) * 1996-04-18 1999-05-11 Alza Corporation Drug delivery device with minimal residual drug retention
US5922353A (en) * 1995-06-07 1999-07-13 Alza Corporation Interlocking couplings for osmotic delivery devices
US5938654A (en) * 1987-06-25 1999-08-17 Alza Corporation Osmotic device for delayed delivery of agent
US5988169A (en) * 1996-03-29 1999-11-23 Iotek, Inc. Vaginal insert and method for treating urogenital disorders
US6030375A (en) * 1996-03-29 2000-02-29 Iotek, Inc. Compressible vaginal insert and method for treating urogenital disorders
WO2000023663A1 (en) 1998-10-21 2000-04-27 Reckitt Benckiser (Uk) Limited Dispensing device
US6120484A (en) * 1999-02-17 2000-09-19 Silverstein; Herbert Otological implant for delivery of medicament and method of using same
US6152943A (en) * 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6153678A (en) * 1997-10-06 2000-11-28 Alza Corporation Injection-moldable composition and article of manufacture comprising same
US6159491A (en) * 1999-02-12 2000-12-12 Biovector Technologies, Inc. Prolonged release bioadhesive vaginal gel dosage form
US6165201A (en) * 1998-08-14 2000-12-26 Incept Llc Method and apparatus for in situ formation of hydrogels
US6179862B1 (en) 1998-08-14 2001-01-30 Incept Llc Methods and apparatus for in situ formation of hydrogels
US6270799B1 (en) 1997-09-25 2001-08-07 Bayer Aktiengesellscahft Medicament formulation with a controlled release of an active agent
US20010041900A1 (en) * 1999-12-21 2001-11-15 Ovion, Inc. Occluding device and method of use
US6342249B1 (en) 1998-12-23 2002-01-29 Alza Corporation Controlled release liquid active agent formulation dosage forms
US20020048600A1 (en) * 1998-11-02 2002-04-25 Padmanabh Bhatt Controlled delivery of active agents
US20020071863A1 (en) * 1999-12-09 2002-06-13 Dong Liang C. Antiviral medication
US20030029457A1 (en) * 1996-12-18 2003-02-13 Callister Jeffrey P. Contraceptive system and method of use
US6558362B1 (en) 1999-02-03 2003-05-06 Bernard Chaffringeon Disposable device for transferring an active liquid into a body cavity
US20030125714A1 (en) * 2001-12-18 2003-07-03 Edgren David Emil Dosage form for time-varying patterns of drug delivery
US6605294B2 (en) 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US20030153864A1 (en) * 2001-10-16 2003-08-14 Bernard Chaffringeon Disposable device and method for transferring an active liquid into a body cavity
US6632457B1 (en) 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US20030198619A1 (en) * 2001-12-19 2003-10-23 Dong Liang C. Formulation and dosage form for increasing oral bioavailability of hydrophilic macromolecules
US20030224051A1 (en) * 2002-05-31 2003-12-04 Fink Tracy A. Dosage forms and compositions for osmotic delivery of variable dosages of oxycodone
US20030232078A1 (en) * 2001-12-19 2003-12-18 Dong Liang C. Formulation & dosage form for the controlled delivery of therapeutic agents
US20040010000A1 (en) * 2002-04-29 2004-01-15 Ayer Atul D. Methods and dosage forms for controlled delivery of oxycodone
US6706282B1 (en) 1998-11-02 2004-03-16 Evangeline Cruz Controlled delivery of phenoxyethyl-substituted 1,2,4-triazolones
US20040091529A1 (en) * 2002-06-26 2004-05-13 David Edgren Methods and dosage forms for increasing solubility of drug compositions for controlled delivery
WO2004043501A1 (en) 2002-11-09 2004-05-27 Reckitt Benckiser (Uk) Limited Improvements in or relating to articles
WO2004048451A2 (en) 2002-11-26 2004-06-10 Genencor International, Inc. Optical information carrier comprising immobilized proteorhodopsin
US20040115262A1 (en) * 2002-07-29 2004-06-17 Frank Jao Formulations and dosage forms for controlled delivery of topiramate
US20040166160A1 (en) * 2003-01-14 2004-08-26 Ramkumar Subramanian Methods and dosage forms with modified viscosity layers
US20040197407A1 (en) * 2003-02-11 2004-10-07 Ramkumar Subramanian Methods and dosage forms with modified layer geometry
US20040219186A1 (en) * 2001-08-16 2004-11-04 Ayres James W. Expandable gastric retention device
WO2004112711A2 (en) 2003-06-16 2004-12-29 Andrx Pharmaceuticals, Llc Oral extended-release composition
US20050031546A1 (en) * 2003-08-06 2005-02-10 Johannes Bartholomaus Abuse-proffed dosage form
US20050045183A1 (en) * 1996-12-18 2005-03-03 Ovion, Inc. Methods and devices for occluding body lumens and/or for delivering therapeutic agents
US20050058707A1 (en) * 2003-08-06 2005-03-17 Iran Reyes Uniform delivery of topiramate over prolonged period of time with enhanced dispersion formulation
US20050069587A1 (en) * 2003-09-02 2005-03-31 Modi Nishit Bachulal Novel drug compositions and dosage forms of topiramate
US20050089570A1 (en) * 2003-09-26 2005-04-28 Evangeline Cruz Oros push-stick for controlled delivery of active agents
US20050106249A1 (en) * 2002-04-29 2005-05-19 Stephen Hwang Once-a-day, oral, controlled-release, oxycodone dosage forms
US20050112195A1 (en) * 2003-09-26 2005-05-26 Evangeline Cruz Drug coating providing high drug loading and methods for providing same
US20050129765A1 (en) * 2003-11-14 2005-06-16 Shaoling Li Controlled release of topiramate in liquid dosage forms
US20050136108A1 (en) * 2003-08-22 2005-06-23 Yam Noymi V. Stepwise delivery of topiramate over prolonged period of time
US20050152843A1 (en) * 2002-06-17 2005-07-14 Johannes Bartholomaus Abuse-proofed dosage form
US20050158382A1 (en) * 2003-09-26 2005-07-21 Evangeline Cruz Controlled release formulations of opioid and nonopioid analgesics
US20050169992A1 (en) * 2003-12-23 2005-08-04 Frank Jao Methods and dosage forms for increasing solubility of drug compositions for controlled delivery
US20050175696A1 (en) * 2003-12-29 2005-08-11 David Edgren Drug granule coatings that impart smear resistance during mechanical compression
US20050175697A1 (en) * 2003-12-29 2005-08-11 David Edgren Novel drug compositions and dosage forms of topiramate
US20050175690A1 (en) * 2003-12-29 2005-08-11 David Edgren Novel drug compositions and dosage forms
US20050192616A1 (en) * 2004-02-02 2005-09-01 Callister Jeffrey P. Contraceptive with permeable and impermeable components
US20050232972A1 (en) * 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
US20050234336A1 (en) * 2004-03-26 2005-10-20 Beckman Andrew T Apparatus and method for marking tissue
US20050232995A1 (en) * 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
US20050236741A1 (en) * 2004-04-22 2005-10-27 Elisabeth Arkenau Process for the production of an abuse-proofed solid dosage form
US20050276848A1 (en) * 2004-06-15 2005-12-15 Nilobon Podhipleux Sustained release neutralized divalproex sodium
US20050276850A1 (en) * 2004-06-15 2005-12-15 Nilobon Podhipleux Controlled release sodium valproate formulation
US20050288551A1 (en) * 2004-04-28 2005-12-29 Ams Research Corporation Endoscopic delivery of medical devices
US20050287213A1 (en) * 2004-06-28 2005-12-29 Wong Patrick S Dosage forms for low solubility and or low dissolution rate free acid pharmaceutical agents
US20050287212A1 (en) * 2004-06-28 2005-12-29 Liang-Chang Dong Oral delivery system comprising a drug/polymer complex
US20050287185A1 (en) * 2004-06-23 2005-12-29 David Wong Extended release oxybutynin formulation
US20060002860A1 (en) * 2004-07-01 2006-01-05 Johannes Bartholomaus Abuse-proofed oral dosage form
US20060002859A1 (en) * 2004-07-01 2006-01-05 Elisabeth Arkenau Process for production of an abuse-proofed solid dosage form
US20060009798A1 (en) * 2004-02-02 2006-01-12 Ams Research Corporation Methods and devices for occluding body lumens and/or enhancing tissue ingrowth
US20060039864A1 (en) * 2004-07-01 2006-02-23 Johannes Bartholomaus Abuse-proofed oral dosage form
US20060057206A1 (en) * 2004-08-19 2006-03-16 Wong Patrick S Controlled release nanoparticle active agent formulation dosage forms and methods
EP1652516A2 (en) 1998-11-02 2006-05-03 ALZA Corporation Osmotic controlled delivery of active agents
US20060189944A1 (en) * 2005-02-08 2006-08-24 Campbell Patrick K Spray for fluent materials
US20060188447A1 (en) * 2005-02-04 2006-08-24 Elisabeth Arkenau-Maric Process for the production of an abuse-proofed dosage form
US20060193914A1 (en) * 2005-02-04 2006-08-31 Judy Ashworth Crush resistant delayed-release dosage forms
US20060233882A1 (en) * 2005-04-15 2006-10-19 Sowden Harry S Osmotic dosage form
US20060257484A1 (en) * 2005-04-19 2006-11-16 Hwang Stephen S Combination of tramadol and substances that comprise gabapentin
US20070003616A1 (en) * 2003-12-24 2007-01-04 Elisabeth Arkenau-Maric Process for the production of an abuse-proofed dosage form
US20070003624A1 (en) * 2005-06-29 2007-01-04 Shanbhag Anant R Semi-permeable compositions providing reduced drying time for osmotic dosage forms
US20070009600A1 (en) * 1993-05-27 2007-01-11 Edgren David E Antidepressant dosage form
US20070031496A1 (en) * 2005-08-04 2007-02-08 Edgren David E Osmotic dosage forms comprising semipermeable membranes with polymer blends providing improved properties
US20070048228A1 (en) * 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
WO2007053698A2 (en) 2005-10-31 2007-05-10 Alza Corporation Methods of reducing alcohol-induced dose dumping for opioid sustained release oral dosage forms
US20070183979A1 (en) * 2003-08-06 2007-08-09 Elisabeth Arkenau-Maric Abuse-proofed dosage form
US20070183980A1 (en) * 2003-08-06 2007-08-09 Elisabeth Arkenau-Maric Dosage form that is safeguarded from abuse
US20070227544A1 (en) * 2006-03-30 2007-10-04 Betsy Swann Methods and devices for deployment into a lumen
US20070243230A1 (en) * 2006-03-31 2007-10-18 Forsight Labs, Llc Nasolacrimal Drainage System Implants for Drug Therapy
US20070281018A1 (en) * 2004-09-24 2007-12-06 Abbott Laboratories Sustained release formulations of opioid and nonopioid analgesics
US20080114092A1 (en) * 1998-12-04 2008-05-15 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
WO2008084698A1 (en) 2006-12-28 2008-07-17 Astellas Pharma Inc. Tacrolimus sustained release pharmaceutical composition
US20080214629A1 (en) * 2007-02-09 2008-09-04 Scott Bull Controlled release compositions of tizanidine
US20090004267A1 (en) * 2007-03-07 2009-01-01 Gruenenthal Gmbh Dosage Form with Impeded Abuse
US20090022798A1 (en) * 2007-07-20 2009-01-22 Abbott Gmbh & Co. Kg Formulations of nonopioid and confined opioid analgesics
US20090088723A1 (en) * 2007-09-28 2009-04-02 Accessclosure, Inc. Apparatus and methods for treating pseudoaneurysms
US20090087484A1 (en) * 2007-09-28 2009-04-02 Alza Corporation Formulation and dosage form for increasing oral bioavailability of hydrophilic macromolecules
US20090098584A1 (en) * 2005-09-01 2009-04-16 Bristol-Myers Squibb Company Biomarkers and Methods for Determining Sensitivity to Vascular Endothelial growth factor Receptor-2 Modulators
US20090104243A1 (en) * 2007-09-07 2009-04-23 Qlt Plug Delivery, Inc. - Qpdi Drug cores for sustained release of therapeutic agents
US20090104248A1 (en) * 2007-09-07 2009-04-23 Qlt Plug Delivery, Inc. -Qpdi Lacrimal implants and related methods
US20090105749A1 (en) * 2007-09-07 2009-04-23 Qlt Plug Delivery, Inc. - Qpdi Insertion and extraction tools for lacrimal implants
US20090118702A1 (en) * 2004-07-02 2009-05-07 Forsight Labs, Llc Treatment Medium Delivery Device and Methods for Delivery of Such Treatment Mediums to the Eye Using such a Delivery Device
US20090123297A1 (en) * 2007-11-08 2009-05-14 Honeywell International Microfluidic osmotic pump
US20090202634A1 (en) * 2008-01-25 2009-08-13 Grunenthal Gmbh Pharmaceutical dosage form
US20090264861A1 (en) * 2008-02-18 2009-10-22 Qlt Plug Delivery, Inc. Lacrimal implants and related methods
US20090280158A1 (en) * 2008-05-09 2009-11-12 Qlt Plug Delivery, Inc. Sustained release delivery of active agents to treat glaucoma and ocular hypertension
US20090317355A1 (en) * 2006-01-21 2009-12-24 Abbott Gmbh & Co. Kg, Abuse resistant melt extruded formulation having reduced alcohol interaction
EP2154241A2 (en) 2008-08-12 2010-02-17 The Regents of the University of Michigan Cell culture well-plates having inverted colloidal crystal scaffolds
US20100040672A1 (en) * 2008-06-09 2010-02-18 Northwestern University Delivery of therapeutics
US20100172989A1 (en) * 2006-01-21 2010-07-08 Abbott Laboratories Abuse resistant melt extruded formulation having reduced alcohol interaction
US20100209478A1 (en) * 2009-02-12 2010-08-19 Sawhney Amarpreet S Drug delivery through hydrogel plugs
US20100274204A1 (en) * 2009-02-23 2010-10-28 Qlt Plug Delivery, Inc. Lacrimal implants and related methods
US20110082214A1 (en) * 2008-05-09 2011-04-07 Gruenthal Gmbh Process for the preparation of a solid dosage form, in particular a tablet, for pharmaceutical use and process for the preparation of a precursor for a solid dosage form, in particular a tablet
WO2011049694A1 (en) 2009-10-23 2011-04-28 Conceptus, Inc. Contraceptive devices
US20110142936A1 (en) * 2009-12-15 2011-06-16 Patrick Campbell Implants and biodegradable fiducial markers
EP2335691A1 (en) 2004-05-11 2011-06-22 Bayer Schering Pharma AG Formulations comprising vardenafil with controlled release of active ingredient
US20110187017A1 (en) * 2010-02-03 2011-08-04 Grunenthal Gmbh Preparation of a powdery pharmaceutical composition by means of an extruder
WO2011122524A1 (en) 2010-03-29 2011-10-06 アステラス製薬株式会社 Controlled release pharmaceutical composition
WO2012025930A3 (en) * 2010-08-25 2012-04-19 Ocure Ltd. Medical instruments of treating and/or diagnosing of anorectal disorders, and devices and methods for insertion of such
US9132088B2 (en) 2008-04-30 2015-09-15 Mati Therapeutics Inc. Composite lacrimal insert and related methods
US9138337B2 (en) 2004-06-30 2015-09-22 Abbott Cardiovascular Systems Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
US9226907B2 (en) 2008-02-01 2016-01-05 Abbvie Inc. Extended release hydrocodone acetaminophen and related methods and uses thereof
WO2016094646A1 (en) 2014-12-10 2016-06-16 Incept, Llc Hydrogel drug delivery implants
US9610271B2 (en) 2011-08-29 2017-04-04 Mati Therapeutics Inc. Sustained release delivery of active agents to treat glaucoma and ocular hypertension
US9636303B2 (en) 2010-09-02 2017-05-02 Gruenenthal Gmbh Tamper resistant dosage form comprising an anionic polymer
US9655853B2 (en) 2012-02-28 2017-05-23 Grünenthal GmbH Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
WO2017091749A1 (en) 2015-11-25 2017-06-01 Incept, Llc Shape changing drug delivery devices and methods
US9737490B2 (en) 2013-05-29 2017-08-22 Grünenthal GmbH Tamper resistant dosage form with bimodal release profile
US9855263B2 (en) 2015-04-24 2018-01-02 Grünenthal GmbH Tamper-resistant dosage form with immediate release and resistance against solvent extraction
US9872835B2 (en) 2014-05-26 2018-01-23 Grünenthal GmbH Multiparticles safeguarded against ethanolic dose-dumping

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US706778A (en) * 1901-12-03 1902-08-12 Edmund Morse Pond Medicated tampon.
US2643027A (en) * 1947-07-26 1953-06-23 Mearl M Fink Uniformly collapsible tube
US2687729A (en) * 1951-03-07 1954-08-31 William V Slavin Medical appliance
US2959250A (en) * 1958-09-15 1960-11-08 Salvador A Minera Lubricant dispenser
US3102540A (en) * 1962-06-19 1963-09-03 Itzhak E Bentov Means for administering medicine
US3202324A (en) * 1961-10-06 1965-08-24 Fr Des Lab Labaz Sa Soc Plastic bags for injectable solutions
US3490454A (en) * 1966-10-21 1970-01-20 United Merchants & Mfg Catamenial products having a coating of rupturable microcapsules containing medicants
US3559646A (en) * 1968-08-16 1971-02-02 Joseph Mullan Tampon
US3760984A (en) * 1971-09-29 1973-09-25 Alza Corp Osmotically powered agent dispensing device with filling means
US3760805A (en) * 1971-01-13 1973-09-25 Alza Corp Osmotic dispenser with collapsible supply container

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US706778A (en) * 1901-12-03 1902-08-12 Edmund Morse Pond Medicated tampon.
US2643027A (en) * 1947-07-26 1953-06-23 Mearl M Fink Uniformly collapsible tube
US2687729A (en) * 1951-03-07 1954-08-31 William V Slavin Medical appliance
US2959250A (en) * 1958-09-15 1960-11-08 Salvador A Minera Lubricant dispenser
US3202324A (en) * 1961-10-06 1965-08-24 Fr Des Lab Labaz Sa Soc Plastic bags for injectable solutions
US3102540A (en) * 1962-06-19 1963-09-03 Itzhak E Bentov Means for administering medicine
US3490454A (en) * 1966-10-21 1970-01-20 United Merchants & Mfg Catamenial products having a coating of rupturable microcapsules containing medicants
US3559646A (en) * 1968-08-16 1971-02-02 Joseph Mullan Tampon
US3760805A (en) * 1971-01-13 1973-09-25 Alza Corp Osmotic dispenser with collapsible supply container
US3760984A (en) * 1971-09-29 1973-09-25 Alza Corp Osmotically powered agent dispensing device with filling means

Cited By (325)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4005699A (en) * 1974-10-09 1977-02-01 Louis Bucalo Methods and apparatus for use in magnetic treatment of the body
US3946734A (en) * 1975-02-19 1976-03-30 The United States Of America As Represented By The Secretary Of State Apparatus for controlling the release of a drug
US4185618A (en) * 1976-01-05 1980-01-29 Population Research, Inc. Promotion of fibrous tissue growth in fallopian tubes for female sterilization
US4041948A (en) * 1976-07-26 1977-08-16 Johnson & Johnson Digital tampon
US4207893A (en) * 1977-08-29 1980-06-17 Alza Corporation Device using hydrophilic polymer for delivering drug to biological environment
US4192308A (en) * 1977-10-25 1980-03-11 Alza Corporation Device using prestretched polymer for dispensing medication
US4203440A (en) * 1978-10-23 1980-05-20 Alza Corporation Device having variable volume chamber for dispensing useful agent
US4304232A (en) * 1979-03-14 1981-12-08 Alza Corporation Unit system having multiplicity of means for dispensing useful agent
US4237893A (en) * 1979-11-28 1980-12-09 Alza Corporation Cervical dilator
US4299222A (en) * 1980-01-08 1981-11-10 Alza Corporation Self-contained suction pump
US4360013A (en) * 1980-04-21 1982-11-23 Minnesota Mining And Manufacturing Company Polymeric acid contraceptive devices
US4350271A (en) * 1980-08-22 1982-09-21 Alza Corporation Water absorbing fluid dispenser
US4455144A (en) * 1980-12-04 1984-06-19 Alza Corporation Dispenser constructed with semipermeable polymer-hydrophilic polymer wall
US4367741A (en) * 1980-12-22 1983-01-11 Alza Corporation Dispenser powered by cross-linked hydrophilic polymer grafted to hydrophilic polymer
EP0168507A1 (en) * 1981-04-27 1986-01-22 Repromed, Inc. Osmotic cervical dilator
US4764380A (en) * 1982-03-22 1988-08-16 Alza Corporation Drug delivery system comprising a volume increasing matrix containing a plurality of tiny pills
WO1984000494A1 (en) * 1982-07-26 1984-02-16 Health Prod Res Dilatation device for the cervix
DE3634864A1 (en) * 1983-11-02 1988-04-14 Alza Corp Delivery device for release of a temperature-responsive mass
US4800056A (en) * 1984-03-21 1989-01-24 Alza Corporation Process for making dispenser with cooperating elements
US4663148A (en) * 1984-03-21 1987-05-05 Alza Corporation Dispenser comprising telescopically engaging members
US4663149A (en) * 1984-03-21 1987-05-05 Alza Corporation Dispenser comprising inner and outer walls functioning as cooperative unit
US4716031A (en) * 1984-03-21 1987-12-29 Alza Corporation Drug dispenser comprising a multiplicity of members acting together for successfully dispensing drug
GB2155889A (en) * 1984-03-21 1985-10-02 Alza Corp Dispenser-capsule
FR2561628A1 (en) * 1984-03-21 1985-09-27 Alza Corp An intake of substances multicomponent operating in unitary integrated system
US4814180A (en) * 1984-03-21 1989-03-21 Alza Corporation Agent dispenser comprising a semipermeable wall surrounding single-piece or two-piece container
US4692326A (en) * 1984-03-21 1987-09-08 Alza Corporation Dispenser comprising inner positioned soft or hard capsule
US4778607A (en) * 1984-04-30 1988-10-18 Marathon Oil Company Method of diluting a concentrated polymer solution for use in a hydrocarbon recovery process
US4851232A (en) * 1987-02-13 1989-07-25 Alza Corporation Drug delivery system with means for obtaining desirable in vivo release rate pattern
US4871542A (en) * 1987-04-30 1989-10-03 Ferring Service Center, N.V. Method and apparatus useful for delivering medicinal compositions into the bladder and urinary tract
US5340590A (en) * 1987-06-25 1994-08-23 Alza Corporation Delivery system with bilayer osmotic engine
US5938654A (en) * 1987-06-25 1999-08-17 Alza Corporation Osmotic device for delayed delivery of agent
US5236689A (en) * 1987-06-25 1993-08-17 Alza Corporation Multi-unit delivery system
US5391381A (en) * 1987-06-25 1995-02-21 Alza Corporation Dispenser capable of delivering plurality of drug units
US4846279A (en) * 1988-01-13 1989-07-11 Marathon Oil Company Method and means for introducing treatment fluid into a well bore
US4855141A (en) * 1988-03-25 1989-08-08 Alza Corporation Device comprising means for protecting and dispensing fluid sensitive medicament
US4959218A (en) * 1988-03-25 1990-09-25 Alza Corporation Method for delivering somatotropin to an animal
US4996060A (en) * 1988-03-25 1991-02-26 Alza Corporation Device comprising liner for protecting fluid sensitive medicament
US5019397A (en) * 1988-04-21 1991-05-28 Alza Corporation Aqueous emulsion for pharmaceutical dosage form
US4931285A (en) * 1988-04-28 1990-06-05 Alza Corporation Aqueous based pharmaceutical coating composition for dosage forms
US5006346A (en) * 1988-04-28 1991-04-09 Alza Corporation Delivery system
US5024842A (en) * 1988-04-28 1991-06-18 Alza Corporation Annealed coats
US5160743A (en) * 1988-04-28 1992-11-03 Alza Corporation Annealed composition for pharmaceutically acceptable drug
US6180129B1 (en) 1988-12-13 2001-01-30 Alza Corporation Polyurethane-containing delivery systems
US5059423A (en) * 1988-12-13 1991-10-22 Alza Corporation Delivery system comprising biocompatible beneficial agent formulation
US5110596A (en) * 1988-12-13 1992-05-05 Alza Corporation Delivery system comprising means for delivering agent to livestock
US5034229A (en) * 1988-12-13 1991-07-23 Alza Corporation Dispenser for increasing feed conversion of hog
US5135523A (en) * 1988-12-13 1992-08-04 Alza Corporation Delivery system for administering agent to ruminants and swine
US5057318A (en) * 1988-12-13 1991-10-15 Alza Corporation Delivery system for beneficial agent over a broad range of rates
US5037420A (en) * 1988-12-13 1991-08-06 Alza Corporation Delivery system comprising two sections for delivering somatotropin
US5174999A (en) * 1988-12-13 1992-12-29 Alza Corporation Delivery system comprising fluid ingress and drug egress
US5980509A (en) * 1988-12-13 1999-11-09 Alza Corporation Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals
US5728088A (en) * 1988-12-13 1998-03-17 Alza Corporation Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals
US5714160A (en) * 1988-12-13 1998-02-03 Alza Corporation Delivery system comprising means for governing fluid ingress into the system
US5630808A (en) * 1988-12-13 1997-05-20 Alza Corporation Delivery system comprising means for governing fluid into the system and for restricting fluid into the system
US5320616A (en) * 1988-12-13 1994-06-14 Alza Corporation Delivery system comprising first walled section and second walled section united by fusion, adhesion or telescopic engagement
US4976966A (en) * 1988-12-29 1990-12-11 Alza Corporation Delayed release osmotically driven fluid dispenser
US5273752A (en) * 1989-07-18 1993-12-28 Alza Corporation Controlled release dispenser comprising beneficial agent
US5126142A (en) * 1989-07-18 1992-06-30 Alza Corporation Dispenser comprising ionophore
US5035897A (en) * 1989-09-05 1991-07-30 Alza Corporation Dosage form for delivering soluble or insoluble drugs
US5474785A (en) * 1990-01-24 1995-12-12 Alza Corporation Delivery system comprising means for controlling internal pressure
US5024663A (en) * 1990-02-21 1991-06-18 Alza Corporation Self-contained suction pump
US5773020A (en) * 1990-04-25 1998-06-30 Vivus, Inc. Treatment of erectile dysfunction
US5282785A (en) * 1990-06-15 1994-02-01 Cortrak Medical, Inc. Drug delivery apparatus and method
US5286254A (en) * 1990-06-15 1994-02-15 Cortrak Medical, Inc. Drug delivery apparatus and method
US5498238A (en) * 1990-06-15 1996-03-12 Cortrak Medical, Inc. Simultaneous angioplasty and phoretic drug delivery
US5628730A (en) * 1990-06-15 1997-05-13 Cortrak Medical, Inc. Phoretic balloon catheter with hydrogel coating
US5234692A (en) * 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5234694A (en) * 1990-07-11 1993-08-10 Alza Corporation Method for increasing feed efficiency in animals
US5234693A (en) * 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5238687A (en) * 1990-07-11 1993-08-24 Alza Corporation Delivery device with a protective sleeve
US5180591A (en) * 1990-07-11 1993-01-19 Alza Corporation Delivery device with a protective sleeve
US5443459A (en) * 1991-01-30 1995-08-22 Alza Corporation Osmotic device for delayed delivery of agent
US5861166A (en) * 1991-03-12 1999-01-19 Alza Corporation Delivery device providing beneficial agent stability
US5458568A (en) * 1991-05-24 1995-10-17 Cortrak Medical, Inc. Porous balloon for selective dilatation and drug delivery
US5198229A (en) * 1991-06-05 1993-03-30 Alza Corporation Self-retaining gastrointestinal delivery device
USRE35601E (en) * 1991-06-12 1997-09-02 Alza Corporation Delivery device providing beneficial agent stability
US5137727A (en) * 1991-06-12 1992-08-11 Alza Corporation Delivery device providing beneficial agent stability
US5240713A (en) * 1991-09-27 1993-08-31 Alza Corporation Dual rate agent delivery device
US5312390A (en) * 1992-01-10 1994-05-17 Alza Corporation Osmotic device with delayed activation of drug delivery
US5223265A (en) * 1992-01-10 1993-06-29 Alza Corporation Osmotic device with delayed activation of drug delivery
US5807306A (en) * 1992-11-09 1998-09-15 Cortrak Medical, Inc. Polymer matrix drug delivery apparatus
JP2008069177A (en) * 1993-05-27 2008-03-27 Alza Corp Antidepressant dosage forms
US8084059B2 (en) 1993-05-27 2011-12-27 Alza Corporation Antidepressant dosage form
US20070009600A1 (en) * 1993-05-27 2007-01-11 Edgren David E Antidepressant dosage form
US6287598B1 (en) 1993-05-28 2001-09-11 Alza Corporation Method for providing sustained antiepileptic therapy
US5707663A (en) * 1993-05-28 1998-01-13 Alza Corporation Sustained antiepileptic therapy
US5980943A (en) * 1993-05-28 1999-11-09 Alza Corporation Sustained antiepileptic therapy
US5498255A (en) * 1993-08-17 1996-03-12 Alza Corporation Osmotic device for protracted pulsatile delivery of agent
US5536243A (en) * 1994-12-13 1996-07-16 Jeyendran; Rajasingam S. Time-release insemination device
US5817335A (en) * 1995-05-26 1998-10-06 Alza Corporation Osmotic device with high drug loading and delayed activation of drug delivery
US5800422A (en) * 1995-06-02 1998-09-01 Alza Corporation Osmotic device with delayed activation of drug delivery and complete drug release
US5922353A (en) * 1995-06-07 1999-07-13 Alza Corporation Interlocking couplings for osmotic delivery devices
US5690952A (en) * 1995-06-07 1997-11-25 Judy A. Magruder et al. Implantable system for delivery of fluid-sensitive agents to animals
US5871770A (en) * 1995-06-07 1999-02-16 Alza Corporation Implantable system for delivery of fluid-sensitive agents to animals
US5988169A (en) * 1996-03-29 1999-11-23 Iotek, Inc. Vaginal insert and method for treating urogenital disorders
US6030375A (en) * 1996-03-29 2000-02-29 Iotek, Inc. Compressible vaginal insert and method for treating urogenital disorders
US5902605A (en) * 1996-04-18 1999-05-11 Alza Corporation Drug delivery device with minimal residual drug retention
US7694683B2 (en) * 1996-12-18 2010-04-13 Conceptus, Inc. Methods and devices for occluding body lumens and/or for delivering therapeutic agents
US20050045183A1 (en) * 1996-12-18 2005-03-03 Ovion, Inc. Methods and devices for occluding body lumens and/or for delivering therapeutic agents
US8707957B2 (en) 1996-12-18 2014-04-29 Bayer Essure Inc. Contraceptive system and method of use
US20080135054A1 (en) * 1996-12-18 2008-06-12 Jeffrey P. Callister Contraceptive system and method of use
US7398780B2 (en) 1996-12-18 2008-07-15 Ams Research Corporation Contraceptive system and method of use
US20030029457A1 (en) * 1996-12-18 2003-02-13 Callister Jeffrey P. Contraceptive system and method of use
US8113205B2 (en) 1996-12-18 2012-02-14 Conceptus, Inc. Contraceptive system and method of use
US6270799B1 (en) 1997-09-25 2001-08-07 Bayer Aktiengesellscahft Medicament formulation with a controlled release of an active agent
US6153678A (en) * 1997-10-06 2000-11-28 Alza Corporation Injection-moldable composition and article of manufacture comprising same
US7413752B2 (en) 1998-08-14 2008-08-19 Incept Llc Composite hydrogel drug delivery systems
US7776063B2 (en) 1998-08-14 2010-08-17 Incept Llc In situ materials formation
US6605294B2 (en) 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US20100119451A1 (en) * 1998-08-14 2010-05-13 Incept, Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US7780980B2 (en) 1998-08-14 2010-08-24 Incept, Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US7648713B2 (en) 1998-08-14 2010-01-19 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US6379373B1 (en) 1998-08-14 2002-04-30 Confluent Surgical, Inc. Methods and apparatus for intraluminal deposition of hydrogels
US7914541B2 (en) 1998-08-14 2011-03-29 Incept, Llc In situ materials formation
US6152943A (en) * 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6632457B1 (en) 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US8105622B2 (en) 1998-08-14 2012-01-31 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US20080132936A1 (en) * 1998-08-14 2008-06-05 Incept Llc In situ materials formation
US20050080445A1 (en) * 1998-08-14 2005-04-14 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6673093B1 (en) 1998-08-14 2004-01-06 Incept Llc Methods and apparatus for in situ formation of hydrogels
US20040009205A1 (en) * 1998-08-14 2004-01-15 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US20080017201A1 (en) * 1998-08-14 2008-01-24 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US20040033264A1 (en) * 1998-08-14 2004-02-19 Incept Llc Composite hydrogel drug delivery systems
US20070288052A1 (en) * 1998-08-14 2007-12-13 Incept Llc In situ materials formation
US7220270B2 (en) 1998-08-14 2007-05-22 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US9254267B2 (en) 1998-08-14 2016-02-09 Incept, Llc Composite hydrogel drug delivery systems
US20060193899A1 (en) * 1998-08-14 2006-08-31 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US6179862B1 (en) 1998-08-14 2001-01-30 Incept Llc Methods and apparatus for in situ formation of hydrogels
US6165201A (en) * 1998-08-14 2000-12-26 Incept Llc Method and apparatus for in situ formation of hydrogels
US20080279944A1 (en) * 1998-08-14 2008-11-13 Incept Llc Composite hydrogel drug delivery systems
US6510561B1 (en) 1998-10-21 2003-01-28 Reckitt Benckiser (Uk) Limited Dispensing device
WO2000023663A1 (en) 1998-10-21 2000-04-27 Reckitt Benckiser (Uk) Limited Dispensing device
US20020048600A1 (en) * 1998-11-02 2002-04-25 Padmanabh Bhatt Controlled delivery of active agents
US6706282B1 (en) 1998-11-02 2004-03-16 Evangeline Cruz Controlled delivery of phenoxyethyl-substituted 1,2,4-triazolones
US6855334B2 (en) 1998-11-02 2005-02-15 Alta Corporation Controlled delivery of active agents
EP1652516A2 (en) 1998-11-02 2006-05-03 ALZA Corporation Osmotic controlled delivery of active agents
US20080114092A1 (en) * 1998-12-04 2008-05-15 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
US6596314B2 (en) 1998-12-23 2003-07-22 Alza Corporation Controlled release liquid active agent formulation dosage forms
US6342249B1 (en) 1998-12-23 2002-01-29 Alza Corporation Controlled release liquid active agent formulation dosage forms
US20030191439A1 (en) * 1999-02-03 2003-10-09 Bernard Chaffringeon Disposable device for transferring an active liquid into a body cavity
US6558362B1 (en) 1999-02-03 2003-05-06 Bernard Chaffringeon Disposable device for transferring an active liquid into a body cavity
US6159491A (en) * 1999-02-12 2000-12-12 Biovector Technologies, Inc. Prolonged release bioadhesive vaginal gel dosage form
US6120484A (en) * 1999-02-17 2000-09-19 Silverstein; Herbert Otological implant for delivery of medicament and method of using same
US20020071863A1 (en) * 1999-12-09 2002-06-13 Dong Liang C. Antiviral medication
US20010041900A1 (en) * 1999-12-21 2001-11-15 Ovion, Inc. Occluding device and method of use
US20040219186A1 (en) * 2001-08-16 2004-11-04 Ayres James W. Expandable gastric retention device
US20070255232A1 (en) * 2001-10-16 2007-11-01 Bernard Chaffringeon Disposable device and method for transferring an active liquid into a body cavity
US20030153864A1 (en) * 2001-10-16 2003-08-14 Bernard Chaffringeon Disposable device and method for transferring an active liquid into a body cavity
US20070207204A1 (en) * 2001-12-18 2007-09-06 Alza Corporation Dosage Form for Time-Varying Patterns of Drug Delivery
US20030125714A1 (en) * 2001-12-18 2003-07-03 Edgren David Emil Dosage form for time-varying patterns of drug delivery
US20030198619A1 (en) * 2001-12-19 2003-10-23 Dong Liang C. Formulation and dosage form for increasing oral bioavailability of hydrophilic macromolecules
US20030232078A1 (en) * 2001-12-19 2003-12-18 Dong Liang C. Formulation & dosage form for the controlled delivery of therapeutic agents
US20040010000A1 (en) * 2002-04-29 2004-01-15 Ayer Atul D. Methods and dosage forms for controlled delivery of oxycodone
US20050106249A1 (en) * 2002-04-29 2005-05-19 Stephen Hwang Once-a-day, oral, controlled-release, oxycodone dosage forms
US20030224051A1 (en) * 2002-05-31 2003-12-04 Fink Tracy A. Dosage forms and compositions for osmotic delivery of variable dosages of oxycodone
US9675610B2 (en) 2002-06-17 2017-06-13 Grünenthal GmbH Abuse-proofed dosage form
US20050152843A1 (en) * 2002-06-17 2005-07-14 Johannes Bartholomaus Abuse-proofed dosage form
US20100260833A1 (en) * 2002-06-17 2010-10-14 Grunenthal Gmbh Abuse-proofed dosage form
US20040091529A1 (en) * 2002-06-26 2004-05-13 David Edgren Methods and dosage forms for increasing solubility of drug compositions for controlled delivery
US9393192B2 (en) 2002-07-29 2016-07-19 Alza Corporation Methods and dosage forms for controlled delivery of paliperidone and risperidone
US20090202631A1 (en) * 2002-07-29 2009-08-13 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
US20050232995A1 (en) * 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
US20040115262A1 (en) * 2002-07-29 2004-06-17 Frank Jao Formulations and dosage forms for controlled delivery of topiramate
US8535653B2 (en) 2002-11-09 2013-09-17 Reckitt Benckiser (Uk) Limited Articles for the release or emanation of vapors
US20060140901A1 (en) * 2002-11-09 2006-06-29 Reckitt Benckiser (Uk) Limited Articles
WO2004043501A1 (en) 2002-11-09 2004-05-27 Reckitt Benckiser (Uk) Limited Improvements in or relating to articles
WO2004048451A2 (en) 2002-11-26 2004-06-10 Genencor International, Inc. Optical information carrier comprising immobilized proteorhodopsin
US20040166160A1 (en) * 2003-01-14 2004-08-26 Ramkumar Subramanian Methods and dosage forms with modified viscosity layers
US20040197407A1 (en) * 2003-02-11 2004-10-07 Ramkumar Subramanian Methods and dosage forms with modified layer geometry
US8628797B2 (en) 2003-06-16 2014-01-14 Andrx Pharmaceuticals, Llc Oral extended-release composition
EP2535042A1 (en) 2003-06-16 2012-12-19 ANDRX Pharmaceuticals LLC. Oral sustained-release composition comprising a macrolide
EP2529730A1 (en) 2003-06-16 2012-12-05 ANDRX Pharmaceuticals LLC. Oral sustained-release composition
US20090124563A1 (en) * 2003-06-16 2009-05-14 Boying Li Oral extended-release composition
WO2004112711A2 (en) 2003-06-16 2004-12-29 Andrx Pharmaceuticals, Llc Oral extended-release composition
KR101200642B1 (en) 2003-06-27 2012-11-12 콘셉투스 인코포레이티드 Methods and devices for occluding body lumens and/or for delivering therapeutic agents
JP2007521081A (en) * 2003-06-27 2007-08-02 エイエムエス・リサーチ・コーポレーション Method and apparatus for making the delivery of occlusion and / or therapeutic agent in the body lumen
US8420056B2 (en) 2003-08-06 2013-04-16 Grunenthal Gmbh Abuse-proofed dosage form
US8192722B2 (en) 2003-08-06 2012-06-05 Grunenthal Gmbh Abuse-proof dosage form
US20080311049A1 (en) * 2003-08-06 2008-12-18 Grunenthal Gmbh Abuse-proof dosage form
US20070048228A1 (en) * 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
US20080247959A1 (en) * 2003-08-06 2008-10-09 Grunenthal Gmbh Form of administration secured against misuse
US9629807B2 (en) 2003-08-06 2017-04-25 Grünenthal GmbH Abuse-proofed dosage form
US20050031546A1 (en) * 2003-08-06 2005-02-10 Johannes Bartholomaus Abuse-proffed dosage form
US20070183979A1 (en) * 2003-08-06 2007-08-09 Elisabeth Arkenau-Maric Abuse-proofed dosage form
US20070183980A1 (en) * 2003-08-06 2007-08-09 Elisabeth Arkenau-Maric Dosage form that is safeguarded from abuse
US8309060B2 (en) 2003-08-06 2012-11-13 Grunenthal Gmbh Abuse-proofed dosage form
US20060193782A1 (en) * 2003-08-06 2006-08-31 Johannes Bartholomaus Abuse-proofed dosage form
US20050058707A1 (en) * 2003-08-06 2005-03-17 Iran Reyes Uniform delivery of topiramate over prolonged period of time with enhanced dispersion formulation
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
US8114383B2 (en) 2003-08-06 2012-02-14 Gruenenthal Gmbh Abuse-proofed dosage form
US20050136108A1 (en) * 2003-08-22 2005-06-23 Yam Noymi V. Stepwise delivery of topiramate over prolonged period of time
US20050069587A1 (en) * 2003-09-02 2005-03-31 Modi Nishit Bachulal Novel drug compositions and dosage forms of topiramate
US20050112195A1 (en) * 2003-09-26 2005-05-26 Evangeline Cruz Drug coating providing high drug loading and methods for providing same
US8246986B2 (en) 2003-09-26 2012-08-21 Alza Corporation Drug coating providing high drug loading
US8226979B2 (en) 2003-09-26 2012-07-24 Alza Corporation Drug coating providing high drug loading and methods for providing the same
US20050089570A1 (en) * 2003-09-26 2005-04-28 Evangeline Cruz Oros push-stick for controlled delivery of active agents
US20060251721A1 (en) * 2003-09-26 2006-11-09 Evangeline Cruz Controlled release formulations of opioid and nonopioid analgesics
US20050158382A1 (en) * 2003-09-26 2005-07-21 Evangeline Cruz Controlled release formulations of opioid and nonopioid analgesics
US20050129765A1 (en) * 2003-11-14 2005-06-16 Shaoling Li Controlled release of topiramate in liquid dosage forms
US20050169992A1 (en) * 2003-12-23 2005-08-04 Frank Jao Methods and dosage forms for increasing solubility of drug compositions for controlled delivery
US20070003616A1 (en) * 2003-12-24 2007-01-04 Elisabeth Arkenau-Maric Process for the production of an abuse-proofed dosage form
US20050175696A1 (en) * 2003-12-29 2005-08-11 David Edgren Drug granule coatings that impart smear resistance during mechanical compression
US20050175690A1 (en) * 2003-12-29 2005-08-11 David Edgren Novel drug compositions and dosage forms
US20050175697A1 (en) * 2003-12-29 2005-08-11 David Edgren Novel drug compositions and dosage forms of topiramate
US20060009798A1 (en) * 2004-02-02 2006-01-12 Ams Research Corporation Methods and devices for occluding body lumens and/or enhancing tissue ingrowth
US9713549B2 (en) 2004-02-02 2017-07-25 Bayer Healthcare Llc Contraceptive with permeable and impermeable components
US20050192616A1 (en) * 2004-02-02 2005-09-01 Callister Jeffrey P. Contraceptive with permeable and impermeable components
US20050234336A1 (en) * 2004-03-26 2005-10-20 Beckman Andrew T Apparatus and method for marking tissue
US20100040670A1 (en) * 2004-04-15 2010-02-18 Qlt Plug Delivery, Inc. Drug delivery via ocular implant
US20050232972A1 (en) * 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
US9463114B2 (en) 2004-04-15 2016-10-11 Mati Therapeutics Inc. Punctal plug with active agent
US20050236741A1 (en) * 2004-04-22 2005-10-27 Elisabeth Arkenau Process for the production of an abuse-proofed solid dosage form
US20080317854A1 (en) * 2004-04-22 2008-12-25 Grunenthal Gmbh Process for the production of an abuse-proofed solid dosage form
US20050288551A1 (en) * 2004-04-28 2005-12-29 Ams Research Corporation Endoscopic delivery of medical devices
US20100168514A1 (en) * 2004-04-28 2010-07-01 Callister Jeffrey P Endoscopic delivery of medical devices
EP2335691A1 (en) 2004-05-11 2011-06-22 Bayer Schering Pharma AG Formulations comprising vardenafil with controlled release of active ingredient
US7713550B2 (en) 2004-06-15 2010-05-11 Andrx Corporation Controlled release sodium valproate formulation
US20050276850A1 (en) * 2004-06-15 2005-12-15 Nilobon Podhipleux Controlled release sodium valproate formulation
US20050276848A1 (en) * 2004-06-15 2005-12-15 Nilobon Podhipleux Sustained release neutralized divalproex sodium
US20050287185A1 (en) * 2004-06-23 2005-12-29 David Wong Extended release oxybutynin formulation
US20050287212A1 (en) * 2004-06-28 2005-12-29 Liang-Chang Dong Oral delivery system comprising a drug/polymer complex
US20050287213A1 (en) * 2004-06-28 2005-12-29 Wong Patrick S Dosage forms for low solubility and or low dissolution rate free acid pharmaceutical agents
US9138337B2 (en) 2004-06-30 2015-09-22 Abbott Cardiovascular Systems Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
US9566373B2 (en) 2004-06-30 2017-02-14 Abbott Cardiovascular Systems Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
US20060002860A1 (en) * 2004-07-01 2006-01-05 Johannes Bartholomaus Abuse-proofed oral dosage form
US8323889B2 (en) 2004-07-01 2012-12-04 Gruenenthal Gmbh Process for the production of an abuse-proofed solid dosage form
US20060002859A1 (en) * 2004-07-01 2006-01-05 Elisabeth Arkenau Process for production of an abuse-proofed solid dosage form
US20060039864A1 (en) * 2004-07-01 2006-02-23 Johannes Bartholomaus Abuse-proofed oral dosage form
US20080312264A1 (en) * 2004-07-01 2008-12-18 Grunenthal Gmbh Process for the production of an abuse-proofed solid dosage form
US20080248113A1 (en) * 2004-07-01 2008-10-09 Grunenthal Gmbh Abuse-proofed oral dosage form
US8114384B2 (en) 2004-07-01 2012-02-14 Gruenenthal Gmbh Process for the production of an abuse-proofed solid dosage form
US20090118702A1 (en) * 2004-07-02 2009-05-07 Forsight Labs, Llc Treatment Medium Delivery Device and Methods for Delivery of Such Treatment Mediums to the Eye Using such a Delivery Device
US9180045B2 (en) 2004-07-02 2015-11-10 Mati Therapeutics Inc. Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such a delivery device
US7922702B2 (en) 2004-07-02 2011-04-12 Qlt Inc. Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such a delivery device
US9820884B2 (en) 2004-07-02 2017-11-21 Mati Therapeutics Inc. Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such delivery device
US20060057206A1 (en) * 2004-08-19 2006-03-16 Wong Patrick S Controlled release nanoparticle active agent formulation dosage forms and methods
US20070281018A1 (en) * 2004-09-24 2007-12-06 Abbott Laboratories Sustained release formulations of opioid and nonopioid analgesics
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US20100151028A1 (en) * 2005-02-04 2010-06-17 Grunenthal Gmbh Crush resistant delayed-release dosage forms
US20080311187A1 (en) * 2005-02-04 2008-12-18 Grunenthal Gmbh Crush resistan delayed-release dosage form
US20060193914A1 (en) * 2005-02-04 2006-08-31 Judy Ashworth Crush resistant delayed-release dosage forms
US20060188447A1 (en) * 2005-02-04 2006-08-24 Elisabeth Arkenau-Maric Process for the production of an abuse-proofed dosage form
US20080311197A1 (en) * 2005-02-04 2008-12-18 Grunenthal Gmbh Process for the production of an abuse-proofed dosage form
US8152777B2 (en) 2005-02-08 2012-04-10 Confluent Surgical, Inc. Spray for fluent materials
US20100057122A1 (en) * 2005-02-08 2010-03-04 Confluent Surgical, Inc Spray for fluent materials
US20060189944A1 (en) * 2005-02-08 2006-08-24 Campbell Patrick K Spray for fluent materials
US8888749B2 (en) 2005-02-08 2014-11-18 Confluent Surgical, Inc. Spray for fluent materials
US7611494B2 (en) 2005-02-08 2009-11-03 Confluent Surgical, Inc. Spray for fluent materials
US20060233882A1 (en) * 2005-04-15 2006-10-19 Sowden Harry S Osmotic dosage form
US20060257484A1 (en) * 2005-04-19 2006-11-16 Hwang Stephen S Combination of tramadol and substances that comprise gabapentin
US20070003624A1 (en) * 2005-06-29 2007-01-04 Shanbhag Anant R Semi-permeable compositions providing reduced drying time for osmotic dosage forms
US20070031496A1 (en) * 2005-08-04 2007-02-08 Edgren David E Osmotic dosage forms comprising semipermeable membranes with polymer blends providing improved properties
US20090098584A1 (en) * 2005-09-01 2009-04-16 Bristol-Myers Squibb Company Biomarkers and Methods for Determining Sensitivity to Vascular Endothelial growth factor Receptor-2 Modulators
WO2007053698A2 (en) 2005-10-31 2007-05-10 Alza Corporation Methods of reducing alcohol-induced dose dumping for opioid sustained release oral dosage forms
US20090221621A1 (en) * 2005-10-31 2009-09-03 Alza Corporation Methods of Reducing Alcohol-Induced Dose Dumping for Opioid Sustained Release Oral Dosage Forms
US20100172989A1 (en) * 2006-01-21 2010-07-08 Abbott Laboratories Abuse resistant melt extruded formulation having reduced alcohol interaction
US20090317355A1 (en) * 2006-01-21 2009-12-24 Abbott Gmbh & Co. Kg, Abuse resistant melt extruded formulation having reduced alcohol interaction
US20070227544A1 (en) * 2006-03-30 2007-10-04 Betsy Swann Methods and devices for deployment into a lumen
US8235047B2 (en) 2006-03-30 2012-08-07 Conceptus, Inc. Methods and devices for deployment into a lumen
US8707958B2 (en) 2006-03-30 2014-04-29 Bayer Essure Inc. Methods and devices for deployment into a lumen
US8747884B2 (en) 2006-03-31 2014-06-10 Mati Therapeutics Inc. Nasolacrimal drainage system implants for drug therapy
US8691265B2 (en) 2006-03-31 2014-04-08 Mati Therapeutics, Inc. Drug delivery methods, structures, and compositions for nasolacrimal system
US7998497B2 (en) 2006-03-31 2011-08-16 Qlt Inc. Nasolacrimal drainage system implants for drug therapy
US8795711B2 (en) 2006-03-31 2014-08-05 Mati Therapeutics Inc. Drug delivery methods, structures, and compositions for nasolacrimal system
US20070243230A1 (en) * 2006-03-31 2007-10-18 Forsight Labs, Llc Nasolacrimal Drainage System Implants for Drug Therapy
US9849082B2 (en) 2006-03-31 2017-12-26 Mati Therapeutics Inc. Nasolacrimal drainage system implants for drug therapy
US9610194B2 (en) 2006-03-31 2017-04-04 Mati Therapeutics Inc. Drug delivery methods, structures, and compositions for nasolacrimal system
US9168222B2 (en) 2006-03-31 2015-10-27 Mati Therapeutics Inc. Nasolacrimal drainage system implants for drug therapy
US20090011018A1 (en) * 2006-12-28 2009-01-08 Astellas Pharma Inc., Sustained release formulation for tacrolimus
WO2008084698A1 (en) 2006-12-28 2008-07-17 Astellas Pharma Inc. Tacrolimus sustained release pharmaceutical composition
US20080214629A1 (en) * 2007-02-09 2008-09-04 Scott Bull Controlled release compositions of tizanidine
US8524749B2 (en) 2007-02-09 2013-09-03 Alza Corporation Controlled release compositions of tizanidine
US20090004267A1 (en) * 2007-03-07 2009-01-01 Gruenenthal Gmbh Dosage Form with Impeded Abuse
US8722086B2 (en) 2007-03-07 2014-05-13 Gruenenthal Gmbh Dosage form with impeded abuse
US20090022798A1 (en) * 2007-07-20 2009-01-22 Abbott Gmbh & Co. Kg Formulations of nonopioid and confined opioid analgesics
US9445944B2 (en) 2007-09-07 2016-09-20 Mati Therapeutics Inc. Lacrimal implants and related methods
US8702643B2 (en) 2007-09-07 2014-04-22 Mati Therapeutics, Inc. Lacrimal implants and related methods
US20090104248A1 (en) * 2007-09-07 2009-04-23 Qlt Plug Delivery, Inc. -Qpdi Lacrimal implants and related methods
US20090105749A1 (en) * 2007-09-07 2009-04-23 Qlt Plug Delivery, Inc. - Qpdi Insertion and extraction tools for lacrimal implants
US8628792B2 (en) 2007-09-07 2014-01-14 Mati Therapeutics, Inc. Drug cores for sustained release of therapeutic agents
US20090104243A1 (en) * 2007-09-07 2009-04-23 Qlt Plug Delivery, Inc. - Qpdi Drug cores for sustained release of therapeutic agents
US8333726B2 (en) 2007-09-07 2012-12-18 Qlt Inc. Lacrimal implants and related methods
US20090087484A1 (en) * 2007-09-28 2009-04-02 Alza Corporation Formulation and dosage form for increasing oral bioavailability of hydrophilic macromolecules
US20090088723A1 (en) * 2007-09-28 2009-04-02 Accessclosure, Inc. Apparatus and methods for treating pseudoaneurysms
US8394644B2 (en) * 2007-11-08 2013-03-12 Honeywell International Inc. Microfluidic osmotic pump
US20090123297A1 (en) * 2007-11-08 2009-05-14 Honeywell International Microfluidic osmotic pump
US8383152B2 (en) 2008-01-25 2013-02-26 Gruenenthal Gmbh Pharmaceutical dosage form
US9750701B2 (en) 2008-01-25 2017-09-05 Grünenthal GmbH Pharmaceutical dosage form
US20090202634A1 (en) * 2008-01-25 2009-08-13 Grunenthal Gmbh Pharmaceutical dosage form
US9226907B2 (en) 2008-02-01 2016-01-05 Abbvie Inc. Extended release hydrocodone acetaminophen and related methods and uses thereof
US20090264861A1 (en) * 2008-02-18 2009-10-22 Qlt Plug Delivery, Inc. Lacrimal implants and related methods
US9216108B2 (en) 2008-02-18 2015-12-22 Mati Therapeutics Inc. Lacrimal implants and related methods
US9132088B2 (en) 2008-04-30 2015-09-15 Mati Therapeutics Inc. Composite lacrimal insert and related methods
US9764066B2 (en) 2008-04-30 2017-09-19 Mati Therapeutics Inc. Composite lacrimal insert and related methods
US20110082214A1 (en) * 2008-05-09 2011-04-07 Gruenthal Gmbh Process for the preparation of a solid dosage form, in particular a tablet, for pharmaceutical use and process for the preparation of a precursor for a solid dosage form, in particular a tablet
US20090280158A1 (en) * 2008-05-09 2009-11-12 Qlt Plug Delivery, Inc. Sustained release delivery of active agents to treat glaucoma and ocular hypertension
US9161917B2 (en) 2008-05-09 2015-10-20 Grünenthal GmbH Process for the preparation of a solid dosage form, in particular a tablet, for pharmaceutical use and process for the preparation of a precursor for a solid dosage form, in particular a tablet
US20100040672A1 (en) * 2008-06-09 2010-02-18 Northwestern University Delivery of therapeutics
EP2154241A2 (en) 2008-08-12 2010-02-17 The Regents of the University of Michigan Cell culture well-plates having inverted colloidal crystal scaffolds
US20100209478A1 (en) * 2009-02-12 2010-08-19 Sawhney Amarpreet S Drug delivery through hydrogel plugs
US8563027B2 (en) 2009-02-12 2013-10-22 Incept, Llc Drug delivery through hydrogel plugs
US8409606B2 (en) 2009-02-12 2013-04-02 Incept, Llc Drug delivery through hydrogel plugs
US20100274204A1 (en) * 2009-02-23 2010-10-28 Qlt Plug Delivery, Inc. Lacrimal implants and related methods
US9421121B2 (en) 2009-10-23 2016-08-23 Bayer Healthcare Llc Contraceptive devices and methods
US8434489B2 (en) 2009-10-23 2013-05-07 Conceptus, Inc. Contraceptive devices and methods
WO2011049694A1 (en) 2009-10-23 2011-04-28 Conceptus, Inc. Contraceptive devices
US20110094519A1 (en) * 2009-10-23 2011-04-28 Vidya Gopal Contraceptive devices and methods
US9308283B2 (en) 2009-12-15 2016-04-12 Incept, Llc Implants and biodegradable fiducial markers
US20110142936A1 (en) * 2009-12-15 2011-06-16 Patrick Campbell Implants and biodegradable fiducial markers
US9669117B2 (en) 2009-12-15 2017-06-06 Incept, Llc Implants and biodegradable tissue markers
US8852646B2 (en) 2009-12-15 2014-10-07 Incept, Llc Particulate implants and biodegradable fiducial markers
US8383161B2 (en) 2009-12-15 2013-02-26 Incept, Llc Radioopaque covalently crosslinked hydrogel particle implants
US20110187017A1 (en) * 2010-02-03 2011-08-04 Grunenthal Gmbh Preparation of a powdery pharmaceutical composition by means of an extruder
US9579285B2 (en) 2010-02-03 2017-02-28 Gruenenthal Gmbh Preparation of a powdery pharmaceutical composition by means of an extruder
WO2011122524A1 (en) 2010-03-29 2011-10-06 アステラス製薬株式会社 Controlled release pharmaceutical composition
US9566420B2 (en) 2010-08-25 2017-02-14 Ocure Ltd. Medical instruments of treating and/or diagnosing of anorectal disorders, and devices and methods for insertion of such
WO2012025930A3 (en) * 2010-08-25 2012-04-19 Ocure Ltd. Medical instruments of treating and/or diagnosing of anorectal disorders, and devices and methods for insertion of such
US9636303B2 (en) 2010-09-02 2017-05-02 Gruenenthal Gmbh Tamper resistant dosage form comprising an anionic polymer
US9610271B2 (en) 2011-08-29 2017-04-04 Mati Therapeutics Inc. Sustained release delivery of active agents to treat glaucoma and ocular hypertension
US9655853B2 (en) 2012-02-28 2017-05-23 Grünenthal GmbH Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
US9737490B2 (en) 2013-05-29 2017-08-22 Grünenthal GmbH Tamper resistant dosage form with bimodal release profile
US9872835B2 (en) 2014-05-26 2018-01-23 Grünenthal GmbH Multiparticles safeguarded against ethanolic dose-dumping
WO2016094646A1 (en) 2014-12-10 2016-06-16 Incept, Llc Hydrogel drug delivery implants
US9855263B2 (en) 2015-04-24 2018-01-02 Grünenthal GmbH Tamper-resistant dosage form with immediate release and resistance against solvent extraction
WO2017091749A1 (en) 2015-11-25 2017-06-01 Incept, Llc Shape changing drug delivery devices and methods

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