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Implantable bulb for inflation of surgical implements

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US3831583A
US3831583A US32964373A US3831583A US 3831583 A US3831583 A US 3831583A US 32964373 A US32964373 A US 32964373A US 3831583 A US3831583 A US 3831583A
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Prior art keywords
bulb
annulus
chamber
tube
wall
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L Edmunds
S Braley
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University of California
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University of California
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02Access sites
    • A61M39/0208Subcutaneous access sites for injecting or removing fluids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/122Clamps or clips, e.g. for the umbilical cord
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0004Closure means for urethra or rectum, i.e. anti-incontinence devices or support slings against pelvic prolapse
    • A61F2/0031Closure means for urethra or rectum, i.e. anti-incontinence devices or support slings against pelvic prolapse for constricting the lumen; Support slings for the urethra
    • A61F2/0036Closure means for urethra or rectum, i.e. anti-incontinence devices or support slings against pelvic prolapse for constricting the lumen; Support slings for the urethra implantable
    • A61F2/004Closure means for urethra or rectum, i.e. anti-incontinence devices or support slings against pelvic prolapse for constricting the lumen; Support slings for the urethra implantable inflatable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00535Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated
    • A61B2017/00557Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated inflatable

Abstract

A device, completely implantable within the human body, for restricting the flow of blood through a major blood vessel, such as an artery, especially the pulmonary artery. An inflatable, flexible annulus, generally circular in shape but not a closed circle, has a non-distensible outer wall so that upon inflation all distension or expansion is inward. The device is placed around an artery or other blood vessel, and the ring may then be closed, as by suturing together preformed tabs attached to the annulus, or by suturing together the ends of an overlapping tape, for instance, to firmly hold the vessel. Upon inflation, inward distension of the inflatable annulus constricts the vessel, and flow of blood therethrough is accordingly restricted. Inflation and deflation are effected through a self-sealing hollow bulb and a non-distensible tube connecting the bulb to the interior of the inflatable annulus, pressure fluid being introduced into the bulb by a fine hypodermic needle. The device may be wholly contained within the patient''s body, and all surfaces thereof are of a substance, such as a medical elastomer, that is compatible with and resistant to the action of body fluids.

Description

United States Patent Edmnnds, Jr. et a1.

[11] 3,831,583 1*Aug. 27, 1974 1 IWLANTABLE BULB FOR INFLATION OF SURGICAL IMPLEMENTS [73] Assignee: The Regents of the University of California, Berkeley, Calif.

[ Notice: The portion of the term of this patent subsequent to May 1, 1990, has been disclaimed.

[22] Filed: Feb. 5, 1973 211 Appl. No.: 329,643

Related US. Application Data [63] Continuation of Ser. No. 121,406, March 5, 1971.

[52] US. Cl 128/1 R, 3/1, 128/346 [51] lint. C1 A611) 19/00 [58] Field of Search. 128/325, 326, 327', 344,

128/346, DIG. 25, 1 R; 3/1

[56] References Cited UNITED STATES PATENTS 3,310,051 3/1967 Schulte 128/216 3,527,220 9/1970 Summers 128/260 3,538,917 11/1970 Selker 128/326 3,600,718 8/1971 Boone 3/36 OTHER PUBLICATIONS In Vivo Metric Systems Bulletin, March 1968, 2 shts. of Bulletin.

Primary ExaminerDalton L. Tfruluck Attorney, Agent, or Firm--Owenl, Wickersham & Erickson [57] ABSTRACT A device, completely implantable within the human body, for restricting the flow of blood through a major blood vessel, such as an artery, especially the pulmonary artery. An inflatable, flexible annulus, generally circular in shape but not a closed circle, has a nondistensible outer wall so that upon inflation all distension or expansion is inward. The device is placed around an artery or other blood vessel, and the ring may then be closed, as by suturing together preformed tabs attached to the annulus, or by suturing together the ends of an overlapping tape, for instance, to firmly hold the vessel. Upon inflation, inward distension of the inflatable annulus constricts the vessel, and flow of blood therethrough is accordingly restricted. Inflation and deflation are effected through a self-sealing hollow bulb and a non-distensible tube connecting the bulb to the interior of the inflatable annulus, pressure fluid being introduced into the bulb by a fine hypodermic needle. The device may be wholly contained within the patients body, and all surfaces thereof are of a substance, such as a medical elastomer, that is compatible with and resistant to the action of body fluids.

9 Claims, 5 Drawing Figures IMPLANTABLE BULB FOR INFLATION OF SURGICAL IMPLEMENTS This is a continuation, of application Ser. No. 121,406, tiled Mar. 5, 1971.

BACKGROUND OF THE INVENTION This invention concerns a means for restricting the rate of flow of bloodthrough an animal blood vessel and particularly through an artery. More especially, it relates to an internal pulmonary arterial band, i.e., a device implantable within a human body for restricting blood flow through the pulmonary artery. The device is suitable for prolonged use within the human body, i.e., for months or even years of such use.

The invention described herein was made in the performance of work under a research grant from the United States Public Health Service.

It has been recognized that approximately eight babies per thousand have congenital heart disease, and, of these, four have greater than normal pulmonary arterial blood flow. Such mechanical defects have led to attempts to develop a safe, reliable, adjustable device to effect arterial banding. Attempts previously have required that mechanical control be applied from outside the body, as by a screw device to manipulate a tape encircling a blood vessel, and heretofore no such device has been capable of being implanted in the body for permanent or at least long-term use.

The present invention provides a device for arterial banding and mechanical restriction of blood flow through an artery, or other major blood vessel. It is safe, is compatible with body fluids, and is controllable externally while being totally contained within the patients body. An advantage of the present invention is that the device is adjustable to conform to the size of the artery being banded and can be permanently emplaced, while yet periodic adjustments continue to be possible, desired. Furthermore, the device is wholly implanted in the body and yet is later controllable with out surgery. Further advantages are that adjustments can easily be made in the amount of inflation to accommodate for somatic growth, pulmonary pressure can be determined with the aid of this device, the band or annulus can be easily reached in order to close it upon emplacement and the connecting tube is short and nontwisting thus preventing interference in any desired flow of liquid.

SUMMARY OF THE INVENTION The present invention provides, in combination, (1) an unclosed annulus or doughnut ring, capable of inward distention only, (2) a non-distensible bulb, (3) a non distensible tube connecting the bulb to the annulus, and (4) means to control penetration by a laterinserted needle or the like and to protect the bulb from undesired punctures.

The annulus is shaped to form an unclosed circle, the circle being left open to enable insertion around an artery. The annulus is closed at both ends and has a distensible inner wall and a non-distensible or substantially non-distensible outer wall. The small nondistensible tube is affixed to the outer wall of the annulus at any convenient point and provides a conduit in open communication with the interior of the annulus through a suitable aperture in the outer wall of the latter. At the end of the tube distant from the annulus is the bulb, which is used to pump fluid through the con duit and into the banding annulus, thereby inflating the annulus and distending the inner wall. The distending of the inner wall exerts pressure on the enclosed portion of the artery or other blood vessel and completely or partially restricts the flow of blood therethrough.

The purposes of having a non-distensible outer wall of the annulus are I) that the effect of inflation of the annulus be directed substantially entirely inwardly toward the enclosed artery, and t 2) that any pressure on the surrounding body structure be avoided or minimized. The desired restraint on the outer wall can be effected in any desired manner, one advantageous means being to affix thereto a reinforcing layer of Teflon (tetrafluoroethylene) tape.

The banding annulus can be made in several sizes to accommodate different situations or needs. For instance, annuli can be supplied in various internal diameters of from about 1.0 cm. to 3.0 cm., e.g., in steps of 0.5 cm. of intervals, the diameters being measured when the annuli are uninflated.

The tube that connects the interior of the annulus to the interior of the bulb is not distensible and is suitably made of Dacron or possibly of hard, non-distensible medical elastomer, such as silicone rubber. The hollow bulb is also not distensible and can be made from the same or similar material. The volume of this bulb is suitably about from 3 to 6 ml. A sink or pan of suitable body-compatible metal, e.g., titanium, and having a base and a side wall conforming to the interior shape of the bulb is disposed within the base of the bulb and facilitates location of the injection chamber with a needle and prevents perforation of the floor or lower wall of the bulb itself. This will be further explained in the more detailed description below. In the insertion or emplacement of the device, the bulb is preferably disposed on the sternum just underneath the patients skin, where it can be readily located by palpation and inflated by means of a needle inserted through the skin.

The interior of the ring, tube and bulb are in open communication with each other and are self-sealing, and they must not'leak. All surfaces of such a device to be wholly implanted in the body are made of a substance compatible with and resistant to the action of body fluids. Such a substance is suitably a medical elastomer such as silicone rubber, of varying degrees of hardness or cure to accommodate the need for distensible or non-distensible portions.

BRIEF DESCRIPTION OF THE DRAWINGS The invention and an advantageous mode of carrying it out are illustrated by the following description and by the annexed drawings, wherein:

FIG. 1 is a view in front elevation of an embodiment of an implantable pulmonary arterial band with the annulus partially inflated; the inner periphery is shown deflated in a broken line.

FIG. 2 is a view in side elevation of the band of FIG. 1.

FIG. 3 is a view in section taken on the line 3-3 of FIG. 1 of an inserted inflated annulus and its relationship to an enclosed artery.

FIG. 4 is a somewhat schematic view in side elevation of the device in place around the pulmonary artery of a patient.

FIG. 5 is a cross-sectional view of an embodiment of a non-distensible bulb of a device according to this invention showing the interior elements.

DETAILED DESCRIPTION OF THE INVENTION For purposes of illustration only, the invention is illustrated by the device shown in the accompanying drawings.

This device is a pulmonary arterial band or extravascular occluder and comprises an inflatable non-closed ring or annulus of flexible material to enable its introduction around an artery to enclose it, a connecting tube 11 and a bulb 12. Each of these components is made of or covered by material which is non-toxic and resistant to attack by body fluids, i.e., does not deteriorate within the body, because the entire device is to be implanted.

The annulus 10 includes an inflatable or balloon inner portion 13 which is formed from a medical elasto- I mer and is flexible and distensible. An advantageous type of such elastomer is the silicone rubber widely available in commerce in medical grades. Preferably, it is made from or includes a self-sealing latex or elastomer. The annulus 10 is in the form of an incomplete or non-closed ring or circle, having two closed, sealed ends 14 and 15 forming an opening 16 therebetween. The outer wall 17 of the annulus 10 is reinforced so that it is not distensible when internal fluid pressure is applied although it, too, remains flexible. This rein forcement can be accomplished in one embodiment as shown by incorporating or embedding a fabric 18, such as nylon or Dacron mesh or cloth, within the outer portion 17 of the silicone rubber annulus 10. The curvature of the casing or annulus 10 helps to direct the nonreinforced inflatable or balloon portion 13 inwardly as it is inflated and to prevent rolling or distortion of such portion 13. An advantageous method of incorporating the fabric 18 in the annulus 10 is to form a coating piece or wire, of the required size and curvature, of such fabric molded into silicone rubber and to weld such tire to the outer surface of an inflatable tube of medical rubber.

The connecting tube 11 can be made from a harder, nondistensible silicone rubber, or of Dacron-reinforced silicone rubber, so that it remains of constant dimensions under the pressures to be applied. It is relatively short and relatively thickwalled so as to be twistresistant and non-kinking. That is, the wall thereof may be from 0.062 to 0.065 inch thick and the tube is of such length as to extend in a substantially straight path, i.e., without curling upon itself, from adjacent the inner surface of the skin-to the blood vessel to be treated. For example, the tube so extends from the sternum to the pulmonary artery area, in one embodiment, and is about 4 inches long. The tube 11 connects with a suitable aperture in the reinforced casing portion 17 and debouches into the interior of the annulus 10, being sealed thereto to prevent leakage. At the end remote from the annulus 10, the tube connects with a suitable aperture in the bulb 12 similarly and is also sealed thereto. Advantageously, the tube 11 connects tangentially to the outer surface of annulus 10, which provides for smoother flow of liquid therethrough and makes easier the placement of the annulus 10 relative to the artery.

The bulb 12 can be formed of a flexible, nondistensible and self-sealing elastomer, such as a suitable reinforced or nonreinforced silicone rubber. It is adapted to being punctured and filled or emptied of a pressure-providing fluid, such as 0.9 percent aqueous saline solution, by using a very fine hypodermic needle, e.g., a No. 22 or 25 needle. Upon withdrawal of the needle the bulb l2 seals itself. This result may be advantageously obtained by providing a bulb 21 of a selfsealing elastomer. In one advantageous embodiment, the bulb 21 contains an upper chamber 26 and a lower chamber 27 separated by an impervious diaphragm 28. Upper chamber 26 contains silicone gel 29, which acts to seal any puncture in bulb 21 caused by insertion of the liquid-injecting needle.

Disposed in lower chamber 27, fitting snugly therein and substantially covering the base and side walls thereof, is a metal sink or pan 30 having a base 31, a side wall 32, and an aperture 33 in the base 31 registering with the central passage 34 in the tube 11. A baffle 35 is spaced from the base 31 by a plurality of legs 36 to provide free flow of liquid into and from the passage 34. In this manner, location of the receptacle for injected liquid is faciliated during such operation and the bottom and side walls of the bulb are protected by the metal from punctures due to insertion of the needle. The diaphragm 28 is suitably extended beyond the exterior wall of the bulb 12 to provide a sewing flange 37. Advantageously aperture 33 can be in the form of a plurality of small holes arranged to form a pattern to register with the interior of tube 11 and to be protected by baffle 35. The elastomer bulb 21 is then provided with a protective coating 22 of silicone rubber which is reinforced with Dacron mesh or the like. Suitably, diaphragm 28 with its flange portion 37 is also of such reinforced rubber. There are also sometimes provided a pair of diametrically disposed anchor or sewing tabs 38, 39, preferably disposed transversely or at right angles to the direction of curvature of the annulus 1'0 and affixed to its outer surface to enable suturing to adventitia of the artery so that the device remains in stable position on the artery being treated.

In using the device of this invention, the pulmonary artery 40 is made accessible by suitable, known surgical procedures, and the artery 40 is inserted within the annulus 10 by way of the opening 16, which may be pulled apart or enlarged as necessary, the ring 10 being quite flexible. After placement of the artery 40 in the annulus l0, ends 24 and 25 of annulus 10 which extend beyond closed ends 14 and 15 thereof may be trimmed if necessary by the surgeon and are then sewn together, suitably using heavy ligatures. The bulb 12 is placed on top of the sternum (not shown) just below the skin where it can be located later by palpation and easily reached by a hypodermic needle to fill or empty the bulb 12 and, through it and connecting tube 1 l, the annulus 10 and the inflatable annulus 10, to inflate and force inwardly distensible portion 13 to constrict the artery 40 as desired, as shown in FIG. 3. The incision in the patient is then closed by the surgeon in the usual manner, the implanted device remaining entirely subcutaneously disposed.

In use of the device after it is emplaced and any incision closed, the hollow bulb 12 is located by palpation and is filled by means of a hypodermic needle, as noted above, introducing a fluid such as 0.9 percent aqueous saline, which flows through the connecting tube 11 into the hollow interior of the annulus 10 causing the inner wall 27 to distend and constrict the artery 26, reducing flow of blood therethrough. The flow of pressure fluid can be aided by manual pressure on the bulb l2. Fluid can be withdrawn, when desired, also by means of a needle. in each case the interior layer of the bulb l2 seals itself, as described.

It will be understood that the above specific description and the drawings have been given for purposes of illustration only and that variations and modifications can be made therein without departing from the spirit and scope of the appended claims. For instance, instead of a permanently fluid pressure substance, the bulb l2 can be filled with a fluid plastic mixed with a catalyst which will cause it to harden in a predetermined time after it fills the inflatable element.

Having described the invention, what is claimed is:

l. A bulb, adapted to be implanted in a human body,

said bulb being non-distensible and self-sealing, and

comprising an upper chamber,

a lower,chamber,

an impervious diaphragm separating said chambers,

a shield means in said lower chamber to protect said lower chamber from puncture by a needle, said shield means being a metal sink having a bottom and a side wall, said sink fitting snugly within said lower chamber substantially covering said side wall and bottom of said chamber, and having an aperture in said bottom, a flexible tube having a central passage registering with said aperture, and

means to anchor said bulb within said body.

2. A totally implantable, flexible, non-distensible self sealable bulb having a hollow interior and being adapted to penetration by a hypodermic needle, and comprising an upper chamber,

a lower chamber, an impervious diaphragm separating said chambers,

silicone rubber gel disposed in said upper chamber,

shield means in said lower chamber to protect said lower chamber from penetration by a needle, said shield means being a metal sink having a bottom and a side wall,

said sink fitting snugly within said lower chamber substantially covering the side wall and base of said chamber, and having an aperture in said bottom registering with the central passage of a flexible connecting tube, and

a nondistensible flexible, twist-resistant tube having a central passage providing a conduit leading from the interior of said bulb.

3. The bulb of claim 2 wherein. said non-distensible tube is formed of silicone rubber.

4. The bulb of claim 2 wherein said tube is relatively thin-walled whereby to resist twisting and kinking so as to enable free and rapid flow of liquid therethrough.

5. The bulb of claim 2 wherein said shield means is a metal sink having a bottom and a side wall, said sink fitting snugly within said lower chamber substantially covering the side wall and base of said chamber, and having an aperture in said bottom.

-6. The bulb of claim 2 wherein. said diaphragm extends to form an annular flange around said bulb.

7. The bulb of claim 5 wherein said metal is titanium.

8. The bulb of claim 5 having a baffle in said sink spaced from and protecting said aperture.

9. The bulb of claim 5 wherein said sink has an aperture of a plurality of small holes arranged in a pattern to register with said central passage.

Claims (9)

1. A bulb, adapted to be implanted in a human body, said bulb being non-distensible and self-sealing, and comprising an upper chamber, a lower chamber, an impervious diaphragm separating said chambers, a shield means in said lower chamber to protect said lower chamber from puncture by a needle, said shield means being a metal sink having a bottom and a side wall, said sink fitting snugly within said lower chamber substantially covering said side wall and bottom of said chamber, and having an aperture in said bottom, a flexible tube having a central passage registering with said aperture, and means to anchor said bulb within said body.
2. A totally implantable, flexible, non-distensible self-sealable bulb having a hollow interior and being adapted to penetration by a hypodermic needle, and comprising an upper chamber, a lower chamber, an impervious diaphragm separating said chambers, silicone rubber gel disposed in said upper chamber, shield means in said lower chamber to protect said lower chamber from penetration by a needle, said shield means being a metal sink having a bottom and a side wall, said sink fitting snugly within said lower chamber substantially covering the side wall and base of said chamber, and having an aperture in said bottom registering with the central passage of a flexible connecting tube, and a non-distensible flexible, twist-resistant tube having a central passage providing a conduit leading from the interior of said bulb.
3. The bulb of claim 2 wherein said non-distensible tube is formed of silicone rubber.
4. The bulb of claim 2 wherein said tube is relatively thin-walled whereby to resist twisting and kinking so as to enable free and rapid flow of liquid therethrough.
5. The bulb of claim 2 wherein said shield means is a metal sink having a bottom and a side wall, said sink fitting snugly within said lower chamber substantially covering the side wall and base of said chamber, and having an aperture in said bottom.
6. The bulb of claim 2 wherein said diaphragm extends to form an annular flange around said bulb.
7. The bulb of claim 5 wherein said metal is titanium.
8. The bulb of claim 5 having a baffle in said sink spaced from and protecting said aperture.
9. The bulb of claim 5 wherein said sink has an aperture of a plurality of small holes arranged in a pattern to register with said central passage.
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Cited By (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3919724A (en) * 1974-06-07 1975-11-18 Medical Eng Corp Implantable prosthesis having a self-sealing valve
DE2604113A1 (en) * 1975-04-07 1976-10-28 Metal Bellows Co infusion pump
US4095295A (en) * 1977-03-28 1978-06-20 Douglas Lake Adjustable, fluid-filled breast implant
US4190040A (en) * 1978-07-03 1980-02-26 American Hospital Supply Corporation Resealable puncture housing for surgical implantation
US4217889A (en) * 1976-09-15 1980-08-19 Heyer-Schulte Corporation Flap development device and method of progressively increasing skin area
DE3012224A1 (en) * 1979-04-11 1980-10-16 Dow Corning Self-sealing injection button and process for its manufacture
US4246893A (en) * 1978-07-05 1981-01-27 Daniel Berson Inflatable gastric device for treating obesity
EP0141625A2 (en) * 1983-11-07 1985-05-15 BAXTER INTERNATIONAL INC. (a Delaware corporation) Self-sealing subcutaneous injection site
US4549529A (en) * 1985-10-11 1985-10-29 White Thomas C Myopia alleviation prosthesis
EP0196837A2 (en) * 1985-03-22 1986-10-08 C.R. Bard, Inc. Urethral sphincter cuff
US4643733A (en) * 1983-04-04 1987-02-17 Hilton Becker Permanent reconstruction implant and method of performing human tissue expansion
US4685447A (en) * 1985-03-25 1987-08-11 Pmt Corporation Tissue expander system
US4708140A (en) * 1986-05-08 1987-11-24 Baron Howard C Atraumatic vascular balloon clamp
US4800879A (en) * 1987-07-09 1989-01-31 Vladimir Golyakhovsky Disposable vascular occluder
US4841992A (en) * 1987-12-17 1989-06-27 Dow Corning Wright Corporation Tissue expander and method of making and using
US5006106A (en) * 1990-10-09 1991-04-09 Angelchik Jean P Apparatus and method for laparoscopic implantation of anti-reflux prosthesis
US5035249A (en) * 1987-12-17 1991-07-30 Dow Corning Wright Corporation Method of making envelope for tissue expander
US5074869A (en) * 1988-09-26 1991-12-24 Daicoff George R Vascular occlusion device
US5593443A (en) * 1991-03-13 1997-01-14 Nph Ltd. Prosthetic anal sphincter
US5797879A (en) * 1996-08-26 1998-08-25 Decampli; William M. Apparatus and methods for providing selectively adjustable blood flow through a vascular graft
US20050240155A1 (en) * 2004-04-27 2005-10-27 Conlon Sean P Surgically implantable injection port having a centered catheter connection tube
US20050240156A1 (en) * 2004-04-27 2005-10-27 Conlon Sean P Method of implanting a fluid injection port
US20050241647A1 (en) * 2002-06-05 2005-11-03 Applied Medical Resources Corporation Wound retractor
WO2006034396A2 (en) * 2004-09-21 2006-03-30 Stout Medical Group, L.P. Balloon and methods of making and using
US20060271088A1 (en) * 2005-05-02 2006-11-30 Almuhannad Alfrhan Percutaneous intragastric balloon device and method
US20080097494A1 (en) * 2006-08-31 2008-04-24 Quebbemann Brian B Fluid port for an adjustable gastric banding system
US20080108949A1 (en) * 2006-11-08 2008-05-08 C. R. Bard, Inc. Resource information key for an insertable medical device
US20080140025A1 (en) * 2005-03-04 2008-06-12 C. R. Bard, Inc. Access port identification systems and methods
US7473221B2 (en) 2000-10-19 2009-01-06 Applied Medical Resources Corporation Surgical access apparatus and method
US20090156928A1 (en) * 2007-11-07 2009-06-18 C. R. Bard, Inc. Radiopaque and septum-based indicators for a multi-lumen implantable port
US20100010530A1 (en) * 2006-07-14 2010-01-14 Ams Research Corporation Balloon Dilation for Implantable Prosthesis
US7704207B2 (en) 2005-10-14 2010-04-27 Applied Medical Resources Corporation Circular surgical retractor
US20100268165A1 (en) * 2005-03-04 2010-10-21 C. R. Bard, Inc. Systems and methods for radiographically identifying an access port
US20110009828A1 (en) * 2009-07-07 2011-01-13 C.R.Bard, Inc. Extensible internal bolster for a medical device
US20110098686A1 (en) * 2001-06-12 2011-04-28 Johns Hopkins University Reservoir Device for Intraocular Drug Delivery
US20110118677A1 (en) * 2009-11-17 2011-05-19 C. R. Bard, Inc. Overmolded access port including anchoring and identification features
US7947022B2 (en) 2005-03-04 2011-05-24 C. R. Bard, Inc. Access port identification systems and methods
US7951076B2 (en) 2003-02-25 2011-05-31 Applied Medical Resources Corporation Surgical access system
US8021324B2 (en) 2007-07-19 2011-09-20 Medical Components, Inc. Venous access port assembly with X-ray discernable indicia
US8025639B2 (en) 2005-04-27 2011-09-27 C. R. Bard, Inc. Methods of power injecting a fluid through an access port
US8109873B2 (en) 2007-05-11 2012-02-07 Applied Medical Resources Corporation Surgical retractor with gel pad
US8157835B2 (en) 2001-08-14 2012-04-17 Applied Medical Resouces Corporation Access sealing apparatus and method
US8177762B2 (en) 1998-12-07 2012-05-15 C. R. Bard, Inc. Septum including at least one identifiable feature, access ports including same, and related methods
US8187177B2 (en) 2003-09-17 2012-05-29 Applied Medical Resources Corporation Surgical instrument access device
US8202259B2 (en) 2005-03-04 2012-06-19 C. R. Bard, Inc. Systems and methods for identifying an access port
US8226552B2 (en) 2007-05-11 2012-07-24 Applied Medical Resources Corporation Surgical retractor
US8257325B2 (en) 2007-06-20 2012-09-04 Medical Components, Inc. Venous access port with molded and/or radiopaque indicia
US8262568B2 (en) 2008-10-13 2012-09-11 Applied Medical Resources Corporation Single port access system
US8343047B2 (en) 2008-01-22 2013-01-01 Applied Medical Resources Corporation Surgical instrument access device
USD676955S1 (en) 2010-12-30 2013-02-26 C. R. Bard, Inc. Implantable access port
US8388526B2 (en) 2001-10-20 2013-03-05 Applied Medical Resources Corporation Wound retraction apparatus and method
USD682416S1 (en) 2010-12-30 2013-05-14 C. R. Bard, Inc. Implantable access port
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
US8641676B2 (en) 2005-04-27 2014-02-04 C. R. Bard, Inc. Infusion apparatuses and methods of use
US20140081311A1 (en) * 2011-05-05 2014-03-20 Relief Therapies, Inc. Device for protecting hemorrhoids
US8703034B2 (en) 2001-08-14 2014-04-22 Applied Medical Resources Corporation Method of making a tack-free gel
US8740766B2 (en) 2010-03-16 2014-06-03 Pelvalon, Inc. Intra-vaginal devices and methods for treating fecal incontinence
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US8905963B2 (en) 2010-08-05 2014-12-09 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US8932271B2 (en) 2008-11-13 2015-01-13 C. R. Bard, Inc. Implantable medical devices including septum-based indicators
US9072578B2 (en) 2010-03-16 2015-07-07 Pelvalon, Inc. Intra-vaginal device for fecal incontinence
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US9289115B2 (en) 2010-10-01 2016-03-22 Applied Medical Resources Corporation Natural orifice surgery system
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US9474756B2 (en) 2014-08-08 2016-10-25 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
US9474888B2 (en) 2005-03-04 2016-10-25 C. R. Bard, Inc. Implantable access port including a sandwiched radiopaque insert
US9492315B2 (en) 2010-08-05 2016-11-15 Forsight Vision4, Inc. Implantable therapeutic device
US9526654B2 (en) 2013-03-28 2016-12-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
US9610432B2 (en) 2007-07-19 2017-04-04 Innovative Medical Devices, Llc Venous access port assembly with X-ray discernable indicia
US9642608B2 (en) 2014-07-18 2017-05-09 Applied Medical Resources Corporation Gels having permanent tack free coatings and method of manufacture
US9717522B2 (en) 2009-08-31 2017-08-01 Applied Medical Resources Corporation Multi-functional surgical access system
US9872702B2 (en) 2016-02-04 2018-01-23 Applied Medical Resources Corporation Natural orifice surgery system

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3310051A (en) * 1963-12-10 1967-03-21 Rudolf R Schulte Surgical reservoir for implantation beneath the skin
US3527220A (en) * 1968-06-28 1970-09-08 Fairchild Hiller Corp Implantable drug administrator
US3538917A (en) * 1968-04-12 1970-11-10 Robert G Selker Balloon occlusion clip
US3600718A (en) * 1969-12-29 1971-08-24 Dow Corning Inflatable prosthesis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3310051A (en) * 1963-12-10 1967-03-21 Rudolf R Schulte Surgical reservoir for implantation beneath the skin
US3538917A (en) * 1968-04-12 1970-11-10 Robert G Selker Balloon occlusion clip
US3527220A (en) * 1968-06-28 1970-09-08 Fairchild Hiller Corp Implantable drug administrator
US3600718A (en) * 1969-12-29 1971-08-24 Dow Corning Inflatable prosthesis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
In Vivo Metric Systems Bulletin, March 1968, 2 shts. of Bulletin. *

Cited By (162)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3919724A (en) * 1974-06-07 1975-11-18 Medical Eng Corp Implantable prosthesis having a self-sealing valve
DE2604113A1 (en) * 1975-04-07 1976-10-28 Metal Bellows Co infusion pump
US4217889A (en) * 1976-09-15 1980-08-19 Heyer-Schulte Corporation Flap development device and method of progressively increasing skin area
US4095295A (en) * 1977-03-28 1978-06-20 Douglas Lake Adjustable, fluid-filled breast implant
US4190040A (en) * 1978-07-03 1980-02-26 American Hospital Supply Corporation Resealable puncture housing for surgical implantation
US4246893A (en) * 1978-07-05 1981-01-27 Daniel Berson Inflatable gastric device for treating obesity
DE3012224A1 (en) * 1979-04-11 1980-10-16 Dow Corning Self-sealing injection button and process for its manufacture
US4643733A (en) * 1983-04-04 1987-02-17 Hilton Becker Permanent reconstruction implant and method of performing human tissue expansion
EP0141625A2 (en) * 1983-11-07 1985-05-15 BAXTER INTERNATIONAL INC. (a Delaware corporation) Self-sealing subcutaneous injection site
US4543088A (en) * 1983-11-07 1985-09-24 American Hospital Supply Corporation Self-sealing subcutaneous injection site
EP0141625A3 (en) * 1983-11-07 1986-04-30 American Hospital Supply Corporation Self-sealing subcutaneous injection site
EP0196837A3 (en) * 1985-03-22 1988-10-05 C.R. Bard, Inc. Urethral sphincter cuff
EP0196837A2 (en) * 1985-03-22 1986-10-08 C.R. Bard, Inc. Urethral sphincter cuff
US4685447A (en) * 1985-03-25 1987-08-11 Pmt Corporation Tissue expander system
US4549529A (en) * 1985-10-11 1985-10-29 White Thomas C Myopia alleviation prosthesis
US4708140A (en) * 1986-05-08 1987-11-24 Baron Howard C Atraumatic vascular balloon clamp
US4800879A (en) * 1987-07-09 1989-01-31 Vladimir Golyakhovsky Disposable vascular occluder
US4841992A (en) * 1987-12-17 1989-06-27 Dow Corning Wright Corporation Tissue expander and method of making and using
US5035249A (en) * 1987-12-17 1991-07-30 Dow Corning Wright Corporation Method of making envelope for tissue expander
US5074869A (en) * 1988-09-26 1991-12-24 Daicoff George R Vascular occlusion device
US5006106A (en) * 1990-10-09 1991-04-09 Angelchik Jean P Apparatus and method for laparoscopic implantation of anti-reflux prosthesis
US5593443A (en) * 1991-03-13 1997-01-14 Nph Ltd. Prosthetic anal sphincter
US5797879A (en) * 1996-08-26 1998-08-25 Decampli; William M. Apparatus and methods for providing selectively adjustable blood flow through a vascular graft
US6053891A (en) * 1996-08-26 2000-04-25 Decampli; William M. Apparatus and methods for providing selectively adjustable blood flow through a vascular graft
US8177762B2 (en) 1998-12-07 2012-05-15 C. R. Bard, Inc. Septum including at least one identifiable feature, access ports including same, and related methods
US8608713B2 (en) 1998-12-07 2013-12-17 C. R. Bard, Inc. Septum feature for identification of an access port
US8911366B2 (en) 2000-10-19 2014-12-16 Applied Medical Resources Corporation Surgical access apparatus and method
US8672839B2 (en) 2000-10-19 2014-03-18 Applied Medical Resource Corporation Surgical access apparatus and method
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US9180046B2 (en) 2001-06-12 2015-11-10 The Johns Hopkins University School Of Medicine Reservoir device for intraocular drug delivery
US9522082B2 (en) 2001-06-12 2016-12-20 The Johns Hopkins University Reservoir device for intraocular drug delivery
US20110098686A1 (en) * 2001-06-12 2011-04-28 Johns Hopkins University Reservoir Device for Intraocular Drug Delivery
US8486052B2 (en) * 2001-06-12 2013-07-16 The Johns Hopkins University School Of Medicine Reservoir device for intraocular drug delivery
US8870904B2 (en) 2001-08-14 2014-10-28 Applied Medical Resources Corporation Access sealing apparatus and method
US8157835B2 (en) 2001-08-14 2012-04-17 Applied Medical Resouces Corporation Access sealing apparatus and method
US8703034B2 (en) 2001-08-14 2014-04-22 Applied Medical Resources Corporation Method of making a tack-free gel
US9669153B2 (en) 2001-08-14 2017-06-06 Applied Medical Resources Corporation Method of manufacturing a tack-free gel for a surgical device
US8388526B2 (en) 2001-10-20 2013-03-05 Applied Medical Resources Corporation Wound retraction apparatus and method
US8973583B2 (en) 2002-06-05 2015-03-10 Applied Medical Resources Corporation Wound retractor
US8235054B2 (en) 2002-06-05 2012-08-07 Applied Medical Resources Corporation Wound retractor
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US7913697B2 (en) 2002-06-05 2011-03-29 Applied Medical Resources Corporation Wound retractor
US20050241647A1 (en) * 2002-06-05 2005-11-03 Applied Medical Resources Corporation Wound retractor
US7650887B2 (en) 2002-06-05 2010-01-26 Applied Medical Resources Corporation Wound retractor
US8932214B2 (en) 2003-02-25 2015-01-13 Applied Medical Resources Corporation Surgical access system
US9295459B2 (en) 2003-02-25 2016-03-29 Applied Medical Resources Corporation Surgical access system
US7951076B2 (en) 2003-02-25 2011-05-31 Applied Medical Resources Corporation Surgical access system
US8357086B2 (en) 2003-09-17 2013-01-22 Applied Medical Resources Corporation Surgical instrument access device
US8187177B2 (en) 2003-09-17 2012-05-29 Applied Medical Resources Corporation Surgical instrument access device
US20050240156A1 (en) * 2004-04-27 2005-10-27 Conlon Sean P Method of implanting a fluid injection port
US20050240155A1 (en) * 2004-04-27 2005-10-27 Conlon Sean P Surgically implantable injection port having a centered catheter connection tube
WO2006034396A2 (en) * 2004-09-21 2006-03-30 Stout Medical Group, L.P. Balloon and methods of making and using
WO2006034396A3 (en) * 2004-09-21 2006-05-11 E Skott Greenhalgh Balloon and methods of making and using
US20110311337A1 (en) * 2005-03-04 2011-12-22 C.R. Bard, Inc. Access port identification systems and methods
US8029482B2 (en) 2005-03-04 2011-10-04 C. R. Bard, Inc. Systems and methods for radiographically identifying an access port
US9603993B2 (en) 2005-03-04 2017-03-28 C. R. Bard, Inc. Access port identification systems and methods
US7785302B2 (en) 2005-03-04 2010-08-31 C. R. Bard, Inc. Access port identification systems and methods
US8939947B2 (en) 2005-03-04 2015-01-27 C. R. Bard, Inc. Systems and methods for radiographically identifying an access port
US20080140025A1 (en) * 2005-03-04 2008-06-12 C. R. Bard, Inc. Access port identification systems and methods
US9682186B2 (en) 2005-03-04 2017-06-20 C. R. Bard, Inc. Access port identification systems and methods
US8998860B2 (en) 2005-03-04 2015-04-07 C. R. Bard, Inc. Systems and methods for identifying an access port
US20100268165A1 (en) * 2005-03-04 2010-10-21 C. R. Bard, Inc. Systems and methods for radiographically identifying an access port
US8202259B2 (en) 2005-03-04 2012-06-19 C. R. Bard, Inc. Systems and methods for identifying an access port
US7959615B2 (en) 2005-03-04 2011-06-14 C. R. Bard, Inc. Access port identification systems and methods
US7947022B2 (en) 2005-03-04 2011-05-24 C. R. Bard, Inc. Access port identification systems and methods
US8382723B2 (en) 2005-03-04 2013-02-26 C. R. Bard, Inc. Access port identification systems and methods
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US8382724B2 (en) 2005-03-04 2013-02-26 C. R. Bard, Inc. Systems and methods for radiographically identifying an access port
US8585663B2 (en) 2005-03-04 2013-11-19 C. R. Bard, Inc. Access port identification systems and methods
US9474888B2 (en) 2005-03-04 2016-10-25 C. R. Bard, Inc. Implantable access port including a sandwiched radiopaque insert
US8603052B2 (en) 2005-03-04 2013-12-10 C. R. Bard, Inc. Access port identification systems and methods
US8025639B2 (en) 2005-04-27 2011-09-27 C. R. Bard, Inc. Methods of power injecting a fluid through an access port
US8475417B2 (en) 2005-04-27 2013-07-02 C. R. Bard, Inc. Assemblies for identifying a power injectable access port
US8545460B2 (en) 2005-04-27 2013-10-01 C. R. Bard, Inc. Infusion apparatuses and related methods
US9421352B2 (en) 2005-04-27 2016-08-23 C. R. Bard, Inc. Infusion apparatuses and methods of use
US8641688B2 (en) 2005-04-27 2014-02-04 C. R. Bard, Inc. Assemblies for identifying a power injectable access port
US8641676B2 (en) 2005-04-27 2014-02-04 C. R. Bard, Inc. Infusion apparatuses and methods of use
US8805478B2 (en) 2005-04-27 2014-08-12 C. R. Bard, Inc. Methods of performing a power injection procedure including identifying features of a subcutaneously implanted access port for delivery of contrast media
US20060271088A1 (en) * 2005-05-02 2006-11-30 Almuhannad Alfrhan Percutaneous intragastric balloon device and method
US9345604B2 (en) * 2005-05-02 2016-05-24 Almuhannad Alfrhan Percutaneous intragastric balloon device and method
US7892172B2 (en) 2005-10-14 2011-02-22 Applied Medical Resources Corporation Circular surgical retractor
US7909760B2 (en) 2005-10-14 2011-03-22 Applied Medical Resources Corporation Split hoop wound retractor with gel pad
US9017254B2 (en) 2005-10-14 2015-04-28 Applied Medical Resources Corporation Hand access laparoscopic device
US9101354B2 (en) 2005-10-14 2015-08-11 Applied Medical Resources Corporation Wound retractor with gel cap
US7883461B2 (en) 2005-10-14 2011-02-08 Applied Medical Resources Wound retractor with gel cap
US7878974B2 (en) 2005-10-14 2011-02-01 Applied Medical Resources Corporation Hand access laparoscopic device
US7815567B2 (en) 2005-10-14 2010-10-19 Applied Medical Resources, Corporation Split hoop wound retractor
US7727146B2 (en) 2005-10-14 2010-06-01 Applied Medical Resources Wound retractor with gel cap
US9474519B2 (en) 2005-10-14 2016-10-25 Applied Medical Resources Corporation Hand access laparoscopic device
US8647265B2 (en) 2005-10-14 2014-02-11 Applied Medical Resources Corporation Hand access laparoscopic device
US7749415B2 (en) 2005-10-14 2010-07-06 Applied Medical Resources Corporation Method of making a hand access laparoscopic device
US7736306B2 (en) 2005-10-14 2010-06-15 Applied Medical Resources Corporation Hand access laparoscopic device
US7704207B2 (en) 2005-10-14 2010-04-27 Applied Medical Resources Corporation Circular surgical retractor
US9649102B2 (en) 2005-10-14 2017-05-16 Applied Medical Resources Corporation Wound retractor with split hoops
US8267858B2 (en) 2005-10-14 2012-09-18 Applied Medical Resources Corporation Wound retractor with gel cap
US8308639B2 (en) 2005-10-14 2012-11-13 Applied Medical Resources Corporation Split hoop wound retractor with gel pad
US8313431B2 (en) 2005-10-14 2012-11-20 Applied Medical Resources Corporation Split hoop wound retractor
US8414487B2 (en) 2005-10-14 2013-04-09 Applied Medical Resources Corporation Circular surgical retractor
US20100010530A1 (en) * 2006-07-14 2010-01-14 Ams Research Corporation Balloon Dilation for Implantable Prosthesis
US20080097494A1 (en) * 2006-08-31 2008-04-24 Quebbemann Brian B Fluid port for an adjustable gastric banding system
US9265912B2 (en) 2006-11-08 2016-02-23 C. R. Bard, Inc. Indicia informative of characteristics of insertable medical devices
US9642986B2 (en) 2006-11-08 2017-05-09 C. R. Bard, Inc. Resource information key for an insertable medical device
US20080108949A1 (en) * 2006-11-08 2008-05-08 C. R. Bard, Inc. Resource information key for an insertable medical device
US8226552B2 (en) 2007-05-11 2012-07-24 Applied Medical Resources Corporation Surgical retractor
US8961410B2 (en) 2007-05-11 2015-02-24 Applied Medical Resources Corporation Surgical retractor with gel pad
US8109873B2 (en) 2007-05-11 2012-02-07 Applied Medical Resources Corporation Surgical retractor with gel pad
US8852160B2 (en) 2007-06-20 2014-10-07 Medical Components, Inc. Venous access port with molded and/or radiopaque indicia
US8257325B2 (en) 2007-06-20 2012-09-04 Medical Components, Inc. Venous access port with molded and/or radiopaque indicia
US9533133B2 (en) 2007-06-20 2017-01-03 Medical Components, Inc. Venous access port with molded and/or radiopaque indicia
US9517329B2 (en) 2007-07-19 2016-12-13 Medical Components, Inc. Venous access port assembly with X-ray discernable indicia
US8021324B2 (en) 2007-07-19 2011-09-20 Medical Components, Inc. Venous access port assembly with X-ray discernable indicia
US9610432B2 (en) 2007-07-19 2017-04-04 Innovative Medical Devices, Llc Venous access port assembly with X-ray discernable indicia
US9579496B2 (en) 2007-11-07 2017-02-28 C. R. Bard, Inc. Radiopaque and septum-based indicators for a multi-lumen implantable port
US20090156928A1 (en) * 2007-11-07 2009-06-18 C. R. Bard, Inc. Radiopaque and septum-based indicators for a multi-lumen implantable port
US8343047B2 (en) 2008-01-22 2013-01-01 Applied Medical Resources Corporation Surgical instrument access device
US8480575B2 (en) 2008-10-13 2013-07-09 Applied Medical Resources Corporation Single port access system
US8894571B2 (en) 2008-10-13 2014-11-25 Applied Medical Resources Corporation Single port access system
US8262568B2 (en) 2008-10-13 2012-09-11 Applied Medical Resources Corporation Single port access system
US8721537B2 (en) 2008-10-13 2014-05-13 Applied Medical Resources Corporation Single port access system
US8932271B2 (en) 2008-11-13 2015-01-13 C. R. Bard, Inc. Implantable medical devices including septum-based indicators
US8808727B2 (en) 2009-01-29 2014-08-19 Forsight Vision4, Inc. Posterior segment drug delivery
US9417238B2 (en) 2009-01-29 2016-08-16 Forsight Vision4, Inc. Posterior segment drug delivery
US8795712B2 (en) 2009-01-29 2014-08-05 Forsight Vision4, Inc. Posterior segment drug delivery
US9851351B2 (en) 2009-01-29 2017-12-26 Forsight Vision4, Inc. Posterior segment drug delivery
US9066779B2 (en) 2009-01-29 2015-06-30 Forsight Vision4, Inc. Implantable therapeutic device
US8715244B2 (en) 2009-07-07 2014-05-06 C. R. Bard, Inc. Extensible internal bolster for a medical device
US20110009828A1 (en) * 2009-07-07 2011-01-13 C.R.Bard, Inc. Extensible internal bolster for a medical device
US9743954B2 (en) 2009-08-31 2017-08-29 Applied Medical Resources Corporation Multifunctional surgical access system
US9717522B2 (en) 2009-08-31 2017-08-01 Applied Medical Resources Corporation Multi-functional surgical access system
US9248268B2 (en) 2009-11-17 2016-02-02 C. R. Bard, Inc. Overmolded access port including anchoring and identification features
US20110118677A1 (en) * 2009-11-17 2011-05-19 C. R. Bard, Inc. Overmolded access port including anchoring and identification features
US9717895B2 (en) 2009-11-17 2017-08-01 C. R. Bard, Inc. Overmolded access port including anchoring and identification features
US9079004B2 (en) 2009-11-17 2015-07-14 C. R. Bard, Inc. Overmolded access port including anchoring and identification features
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
US9707067B2 (en) 2010-03-16 2017-07-18 Pelvalon, Inc. Intra-vaginal devices and methods for treating fecal incontinence
US8740766B2 (en) 2010-03-16 2014-06-03 Pelvalon, Inc. Intra-vaginal devices and methods for treating fecal incontinence
US9289278B2 (en) 2010-03-16 2016-03-22 Pelvalon, Inc. Intra-vaginal devices and methods for treating fecal incontinence
US9072578B2 (en) 2010-03-16 2015-07-07 Pelvalon, Inc. Intra-vaginal device for fecal incontinence
US8740767B2 (en) 2010-03-16 2014-06-03 Pelvalon, Inc. Intra-vaginal devices and methods for treating fecal incontinence
US9492315B2 (en) 2010-08-05 2016-11-15 Forsight Vision4, Inc. Implantable therapeutic device
US9033911B2 (en) 2010-08-05 2015-05-19 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US9861521B2 (en) 2010-08-05 2018-01-09 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US8905963B2 (en) 2010-08-05 2014-12-09 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
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US9289200B2 (en) 2010-10-01 2016-03-22 Applied Medical Resources Corporation Natural orifice surgery system
USD682416S1 (en) 2010-12-30 2013-05-14 C. R. Bard, Inc. Implantable access port
USD676955S1 (en) 2010-12-30 2013-02-26 C. R. Bard, Inc. Implantable access port
US20140081311A1 (en) * 2011-05-05 2014-03-20 Relief Therapies, Inc. Device for protecting hemorrhoids
US9192366B2 (en) 2011-05-10 2015-11-24 Applied Medical Resources Corporation Wound retractor
US9307975B2 (en) 2011-05-10 2016-04-12 Applied Medical Resources Corporation Wound retractor
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US9241697B2 (en) 2011-05-10 2016-01-26 Applied Medical Resources Corporation Wound retractor
US9872788B2 (en) * 2012-04-30 2018-01-23 Relief Therapies, Inc. Device for protecting hemorrhoids
US9526654B2 (en) 2013-03-28 2016-12-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
US9642608B2 (en) 2014-07-18 2017-05-09 Applied Medical Resources Corporation Gels having permanent tack free coatings and method of manufacture
US9474756B2 (en) 2014-08-08 2016-10-25 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
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