US3823718A - Portable cryosurgical apparatus - Google Patents

Portable cryosurgical apparatus Download PDF

Info

Publication number
US3823718A
US3823718A US28975372A US3823718A US 3823718 A US3823718 A US 3823718A US 28975372 A US28975372 A US 28975372A US 3823718 A US3823718 A US 3823718A
Authority
US
Grant status
Grant
Patent type
Prior art keywords
means
container
end
cryogenic liquid
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
T Tromovitch
Original Assignee
T Tromovitch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A61B18/0218Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques with open-end cryogenic probe, e.g. for spraying fluid directly on tissue or via a tissue-contacting porous tip

Abstract

This invention relates to cryosurgery, and more particularly to the delivery and application of liquified gas coolant to living tissue in order to necrotize the same.

Description

United States Patent 1191 Tromovitch July 16, 1974 PORTABLE CRYOSURGICAL APPARATUS 3,485,060 12/1969 Ziegler 128/303.1 x 3,630,203 I2 I97] S ll' t'l. I28 303.l I76] Inventor: Theldore Tromovltch 1667 3,651,813 311972 128/3031 Escalante Way, Burlmgame, Callf. 94010 FOREIGN PATENTS OR APPLICATIONS I FI'ZIIICC [211 Appl No: 289,753 OTHER PUBLICATIONS Marshall, Principles and Practice of Operative Den- 52 us. c1 128/303.1,222/382, 222/383, ph'ladelphia 8 222/397, 222538 and London, 1901. [51 Int. Cl A61b 17/36, 867d 5/40 [58 Field 01 Search ..'B67d/5/54; 128/303.1; Primary Emmmer(hanmng Pace 222 397 39 332 333 53 Attorney, Agent, or FzrmRobert Charles H1II [56] References Cited [57] ABSTRACT UNITED STATES PATENTS This invention relates to cryosurgery, and more partic- 367,474 8/1887 Truman 222/538 X ularly to the delivery and application of Iiquified gas Donathen X coolant to tissue in order to necrotize the ame I,009,980 ll/I9Il Leisure et al. 1,651,256 1 1/1927 Davis 222/39? 2 Claims, 3 Drawing Figures 1 PORTABLE CRYOSURGICAL APPARATUS BACKGROUND OF THE INVENTION DESCRIPTION OF THE PREFERRED EMBODIMENT Referring now to FIG. 1, there is illustrated a cryo- It has long been known in the prior art to use liquified 5 genie system including a supply container having a gas (such as helium, nitrogen, oxygen, air, freon, zenon, carbon dioxide, etc.) to freeze healthy or diseased tissue, and thereby necrotize the tissue. For instance, one well-known use of liquified gas in cryosurgery is the removal of lesions, both on the skin and internally. Usually, the object is to remove the lesion by destroying the tissue; in other cases, the object is the destruction of the tissue while maintaining adjacent portions of the tissue structure in place, such as in the walls of vital organs. As used herein, lesion means diseased tissue which is to be frozen; the destruction of lesions includes removal of tissue for cosmetic purposes, and killing of tissues as a complimentary modality to surgical procedures.

However, prior art devices have been very inefficient due to very poor or lack of insulation in the containers holding the cryogenic liquid with the result that ambient heat prematurely gasifies the cryogenic liquid and same is vented to atmosphere through safety exhaust means, etc. A further drawback of prior art devices resides in their awkward construction whereby the container holding the cryogenic liquid is oftentimes integrally associated with the discharge nozzle for the cryogenie fluid. In many cases such a construction leads to severe operator fatigue and also hampers the use of the apparatus since only one hand is free to operate the surgical device while the operators other hand is occupied with the holding of the container or the operation of levers, etc. A still further disadvantage of some prior art devices is that they include 17 liter or 30 liter tanks which contain the coolant, thus making thev structure heavy and cumbersome and almost'impossible to transport for house calls and/or visits to nursing homes and hospitals.

Accordingly, it is the primary object of the present invention to provide improved cryosurgical apparatus in which the cryogenic liquid iscontained in a completely. insulated container and which is normally not vented to atmosphere. 1

A further object. of the invention is to provide apparatus which does not require the use ofa finger or footsuitable cryogenic liquid 12 contained therein. The container 10 comprises a base member 14 into which is seated an insulated bottle 16 which is preferably a double walled vacuum bottle.

. The cryogenic liquid 12 may be any nonexplodable, nontoxic, low molecular weight substance. Of those substances meeting the aforementioned requirements,

' the choice of liquid will depend upon the temperature operated lever, etc.. during actual surgical use of the device.

A'further object of the invention is the provision of a simple manually operated fluid pressure producing device for selectively applying pressure to the cryogenic fluid in the container for delivery of same to the outlet nozzle. p

A still further object is to provide a small selfcontained hand carryable apparatus which is readily portable.

BRIEF DESCRIPTION OF THE DRAWINGS of the device shown in FIG. 1 when rotated 90 to illustrate additional features of the inventionyand-v FIG. 3 is a top plan view of the present invention.

at which the surgeon or dermatologist chooses to perform the operation. For most applications the preferred substance is liquid nitrogen.

The top of the insulated bottle 16 is provided with a removable closure 18 which engages the bottle in fluid tight relation as shown in the drawing. As best shown in FIG. 2, the closure 18 is provided with three tubular orifices 20, 22 and 24 extending therethrough for communication with a chamber 26 defined by the insulated bottle 16. g

Extending through the orifice 20 is a tubing 28, preferably of nylon, having a first end 30 submerged below the level of the cryogenic liquid 12. Near the second or remote end 32 of tubing 28 there is provided insulated handle means 34. A desirable material for the thermally insulative handle 34 comprises plastic layers,

such as polystyrene, superimposed upon one another and then heated and joined in a vacuum chamber. Such materials exhibit very poor thermal conductivity and also have great tensile strength. In addition, insulative materials as shown at 36 may be placed between the handle 34 and tube end 32 as desired.

At the remote end 32 of the tubing 28 there is provided a nozzle means 38 which is removably connected to a shank 40 formed in the outer end of handle 34 and into which the end 32 of tubing 28 terminates. The shank 40 may receive any one of several nozzles, such as by a threaded connection, and as shown in FIGS. 1

and 3 an auxiliary nozzle 42 may be stored on a shank formedon the top of closure 18. All such nozzles may be regulated in a known fashion, such as by rotating same, from a completely closed position to a fine mistlike spray or a small diameter highly localized stream.

considerable periods of time and it is obvious that excessive weight or awkwardness caused by having to move the liquid container during operation is not desirable.

Referring back to-FIG. 2, it may be observed that a second flexible tubing 46 communicates through closure orifice 22 with the space located in chamber 26 above the level of cryogenic liquid 12. The outer end 48of tube 46 is suitably attached to a conventional air bulb 50. Thefair bulb is used to selectively apply pressure to the space in chamber 26 located above the level of cryogenic liquid 12. A suitable valve means 52, such as a screw valve, may be employed to close off the air bulb 50 when same is not in use.

As also shown in FIG. 2, there is provided safety valve means 54 formed on the closure 18 and in communication with closure orifice 24 which orifice is in communication with the space in chamber 26 located above the level of cryogenic liquid 12. The safety valve 54 is set to open at any given pressure above the normal pressure maintained in chamber 26 of container 10. For example, the valve may be set to open at any time the pressure in chamber 26 rises three pounds above normal pressure in said chamber, such for example as when pressure is being applied to said chamber from the air bulb 50 and exceeds the desired level. FIG. 3 illustrates the relative positions on the enclosure 18 of tubing 28, tubing 46, auxiliary nozzle 42, and safety valve means 54.

During operation of the device of the present invention, the container is filled with liquified gas coolant, such as liquid nitrogen, to a suitable level. The operator then directs the nozzle 38 toward the tissue and, after opening valve 52, administers pressure to the chamber 26 above the level of cryogenic liquid 12 by squeezing air bulb 50. This pressure forces the liquid nitrogen 12 into delivery tube 28 and through nozzle 38. The length of delivery tube 28 can be selected such that by the time the cryogenic fluid reaches the outlet orifice of nozzle 38, it comprises a desired gas-liquid ratio, such as, for example, 90 percent gas and 10 percent liquid. It should also be understood that the duration of use also influences the gas-liquid ratio. Thus, the longer the continuous use, the greater the percentage of liquid flowing through nozzle 38. Typical usages vary from five seconds up to and including several minutes. If at any time during operation of the device the pressure in chamber 26 exceeds the desired level, the pressure safety valve 54 will open and vent the chamber to atmosphere until such time as conditions have stabilized.

It can therefore be seen that the new and improved cryosurgical apparatus of the present invention provides a portable self-contained unit which is easy to operate in a manner that maximizes the effective use of the coolant.

' What is claimed is:

l. A portable cryosurgical instrument comprising: insulated container means having an upper end and a lower end; a quantity of cryogenic liquid within said container means having an upper level;

removable closure means sealably engaging the upper end of said container means;

first tubular means extending through said closure means and having one end thereof communicating with said cryogenic liquid below the upper level thereof for selectively transferring said liquid from said container to a spray nozzle means located at the other end of said first tubular means;

means for selectively administering pressure through said closure means to the upper level of said cryogenic liquid to force said liquid through said first tubular means; direct response safety valve means on said closure means for venting said container to atmosphere when the pressure therein exceeds a predetermined level; and

insulated handle means on said other end of said first tubular means near said nozzle means;

whereby effective use is made of said cryogenic liquid so thatnumerous patients may be treated at different locations on one fill of cryogenic liquid.

2. The portable cryosurgical instrument of claim 1 additionally comprising spray nozzle storage means on said container closure means.

Claims (2)

1. A portable cryosurgical instrument comprising: insulated container means having an upper end and a lower end; ''a quantity of cryogenic liquid within said container means having an upper level; removable closure means sealably engaging the upper end of said container means; first tubular means extending through said closure means and having one end thereof communicating with said cryogenic liquid below the upper level thereof for selectively transferring said liquid from said container to a spray nozzle means located at the other end of said first tubular means; means for selectively administering pressure through said closure means to the upper level of said cryogenic liquid to force said liquid through said first tubular means; direct response safety valve means on said closure means for venting said container to atmosphere when the pressure therein exceeds a predetermined level; and insulated handle means on said other end of said first tubular means near said nozzle means; whereby effective use is made of said cryogenic liquid so that numerous patients may be treated at different locations on one fill of cryogenic liquid.
2. The portable cryosurgical instrument of claim 1 additionally comprising spray nozzle storage means on said container closure means.
US3823718A 1972-09-15 1972-09-15 Portable cryosurgical apparatus Expired - Lifetime US3823718A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US3823718A US3823718A (en) 1972-09-15 1972-09-15 Portable cryosurgical apparatus

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3823718A US3823718A (en) 1972-09-15 1972-09-15 Portable cryosurgical apparatus

Publications (1)

Publication Number Publication Date
US3823718A true US3823718A (en) 1974-07-16

Family

ID=23112930

Family Applications (1)

Application Number Title Priority Date Filing Date
US3823718A Expired - Lifetime US3823718A (en) 1972-09-15 1972-09-15 Portable cryosurgical apparatus

Country Status (1)

Country Link
US (1) US3823718A (en)

Cited By (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3889681A (en) * 1974-10-30 1975-06-17 Jack Douglas Waller Cryosurgical spraying apparatus
US3971383A (en) * 1974-05-07 1976-07-27 Erbe Elektromedizin Kg Cryogenic surgical instrument
US4043341A (en) * 1975-12-09 1977-08-23 Tromovitch Theodore A Portable cryosurgical instrument
US4072152A (en) * 1976-02-23 1978-02-07 Linehan John H Orthopedic cryosurgical apparatus
US4116199A (en) * 1976-12-06 1978-09-26 Brymill Corporation Cryosurgical instrument reservoir
US4220154A (en) * 1976-12-11 1980-09-02 Kurt Semm Device for coagulating biological tissue
EP0060480A1 (en) * 1981-03-18 1982-09-22 Messer Griesheim Gmbh Device for handling and dosing small volumes of super-cooled liquids
US5108390A (en) * 1988-11-14 1992-04-28 Frigitronics, Inc. Flexible cryoprobe
US5147355A (en) * 1988-09-23 1992-09-15 Brigham And Womens Hospital Cryoablation catheter and method of performing cryoablation
US5277642A (en) * 1991-12-23 1994-01-11 Dorta Juan F Combination toy and beverage dispensing device
US5281215A (en) * 1992-04-16 1994-01-25 Implemed, Inc. Cryogenic catheter
US5281213A (en) * 1992-04-16 1994-01-25 Implemed, Inc. Catheter for ice mapping and ablation
US5400923A (en) * 1988-06-20 1995-03-28 Helena Laboratories Corporation Apparatus for discharging contents of a sealed container
US5415329A (en) * 1993-06-22 1995-05-16 Tosca Limited Container including a pressure relief valve for use in holding and dispensing soft drink material
US5423807A (en) * 1992-04-16 1995-06-13 Implemed, Inc. Cryogenic mapping and ablation catheter
US5474210A (en) * 1992-02-27 1995-12-12 Pump Products, Inc. Fluid dispensing device
US5846235A (en) * 1997-04-14 1998-12-08 Johns Hopkins University Endoscopic cryospray device
US5960998A (en) * 1994-08-10 1999-10-05 Brown; Don W. Insulated spray bottle
US6035646A (en) * 1998-07-07 2000-03-14 Brymill Corporation Liquid cryogen withdrawal device with pump
US6161543A (en) * 1993-02-22 2000-12-19 Epicor, Inc. Methods of epicardial ablation for creating a lesion around the pulmonary veins
US6383181B1 (en) * 1997-05-23 2002-05-07 Frank Majerowicz Method and apparatus for cryogenic spray ablation of gastrointestinal mucosa
US6551309B1 (en) 2000-09-14 2003-04-22 Cryoflex, Inc. Dual action cryoprobe and methods of using the same
US7083620B2 (en) 2002-10-30 2006-08-01 Medtronic, Inc. Electrosurgical hemostat
US7094235B2 (en) 2001-04-26 2006-08-22 Medtronic, Inc. Method and apparatus for tissue ablation
US7118566B2 (en) 2002-05-16 2006-10-10 Medtronic, Inc. Device and method for needle-less interstitial injection of fluid for ablation of cardiac tissue
US7128740B2 (en) 1996-05-03 2006-10-31 Jacobs Clemens J Method for interrupting conduction paths within the heart
US7156845B2 (en) 1998-07-07 2007-01-02 Medtronic, Inc. Method and apparatus for creating a bi-polar virtual electrode used for the ablation of tissue
US7166105B2 (en) 1995-02-22 2007-01-23 Medtronic, Inc. Pen-type electrosurgical instrument
US7169144B2 (en) 1998-07-07 2007-01-30 Medtronic, Inc. Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue
US7250048B2 (en) 2001-04-26 2007-07-31 Medtronic, Inc. Ablation system and method of use
US7294143B2 (en) 2002-05-16 2007-11-13 Medtronic, Inc. Device and method for ablation of cardiac tissue
US20070276360A1 (en) * 1997-05-23 2007-11-29 Csa Medical, Inc. Heated catheter used in cryotherapy
US7309325B2 (en) 1998-07-07 2007-12-18 Medtronic, Inc. Helical needle apparatus for creating a virtual electrode used for the ablation of tissue
US20080015562A1 (en) * 2001-04-26 2008-01-17 Medtronic, Inc. Transmural ablation systems and methods
US7347858B2 (en) 2001-12-11 2008-03-25 Medtronic, Inc. Method and system for treatment of atrial tachyarrhythmias
US7364578B2 (en) 2002-01-25 2008-04-29 Medtronic, Inc. System and method of performing an electrosurgical procedure
US7367972B2 (en) 2001-04-26 2008-05-06 Medtronic, Inc. Ablation system
US7435250B2 (en) 2000-04-27 2008-10-14 Medtronic, Inc. Method and apparatus for tissue ablation
US7470272B2 (en) 1997-07-18 2008-12-30 Medtronic, Inc. Device and method for ablating tissue
US7497857B2 (en) 2003-04-29 2009-03-03 Medtronic, Inc. Endocardial dispersive electrode for use with a monopolar RF ablation pen
US7507235B2 (en) 2001-01-13 2009-03-24 Medtronic, Inc. Method and system for organ positioning and stabilization
US7566334B2 (en) 2004-06-02 2009-07-28 Medtronic, Inc. Ablation device with jaws
US20090192504A1 (en) * 2008-01-29 2009-07-30 Csa Medical, Inc. Cryosurgery system having unintegrated delivery and visualization apparatus
US7615015B2 (en) 2000-01-19 2009-11-10 Medtronic, Inc. Focused ultrasound ablation devices having selectively actuatable emitting elements and methods of using the same
US7628780B2 (en) 2001-01-13 2009-12-08 Medtronic, Inc. Devices and methods for interstitial injection of biologic agents into tissue
US7678108B2 (en) 2004-06-02 2010-03-16 Medtronic, Inc. Loop ablation apparatus and method
US7706882B2 (en) 2000-01-19 2010-04-27 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area
US7706894B2 (en) 2000-10-10 2010-04-27 Medtronic, Inc. Heart wall ablation/mapping catheter and method
US7740623B2 (en) 2001-01-13 2010-06-22 Medtronic, Inc. Devices and methods for interstitial injection of biologic agents into tissue
US7744562B2 (en) 2003-01-14 2010-06-29 Medtronics, Inc. Devices and methods for interstitial injection of biologic agents into tissue
US7758580B2 (en) 2004-06-02 2010-07-20 Medtronic, Inc. Compound bipolar ablation device and method
US7758576B2 (en) 2004-06-02 2010-07-20 Medtronic, Inc. Clamping ablation tool and method
US7818039B2 (en) 2000-04-27 2010-10-19 Medtronic, Inc. Suction stabilized epicardial ablation devices
US7824399B2 (en) 2001-04-26 2010-11-02 Medtronic, Inc. Ablation system and method of use
US7967816B2 (en) 2002-01-25 2011-06-28 Medtronic, Inc. Fluid-assisted electrosurgical instrument with shapeable electrode
US8162933B2 (en) 2000-04-27 2012-04-24 Medtronic, Inc. Vibration sensitive ablation device and method
US8221402B2 (en) 2000-01-19 2012-07-17 Medtronic, Inc. Method for guiding a medical device
US8333764B2 (en) 2004-05-12 2012-12-18 Medtronic, Inc. Device and method for determining tissue thickness and creating cardiac ablation lesions
US8409219B2 (en) 2004-06-18 2013-04-02 Medtronic, Inc. Method and system for placement of electrical lead inside heart
US8512337B2 (en) 2001-04-26 2013-08-20 Medtronic, Inc. Method and system for treatment of atrial tachyarrhythmias
US8568409B2 (en) 2000-03-06 2013-10-29 Medtronic Advanced Energy Llc Fluid-assisted medical devices, systems and methods
US8632533B2 (en) 2009-02-23 2014-01-21 Medtronic Advanced Energy Llc Fluid-assisted electrosurgical device
US8663245B2 (en) 2004-06-18 2014-03-04 Medtronic, Inc. Device for occlusion of a left atrial appendage
US8801707B2 (en) 2004-05-14 2014-08-12 Medtronic, Inc. Method and devices for treating atrial fibrillation by mass ablation
US8821488B2 (en) 2008-05-13 2014-09-02 Medtronic, Inc. Tissue lesion evaluation
US8906012B2 (en) 2010-06-30 2014-12-09 Medtronic Advanced Energy Llc Electrosurgical devices with wire electrode
US8926635B2 (en) 2004-06-18 2015-01-06 Medtronic, Inc. Methods and devices for occlusion of an atrial appendage
US9227088B2 (en) 2006-05-25 2016-01-05 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
US9381061B2 (en) 2000-03-06 2016-07-05 Medtronic Advanced Energy Llc Fluid-assisted medical devices, systems and methods
US20170071530A1 (en) * 2015-09-14 2017-03-16 Gerald KABAN Thermal tooth testing devices, methods and kits
US9974599B2 (en) 2014-08-15 2018-05-22 Medtronic Ps Medical, Inc. Multipurpose electrosurgical device

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US367474A (en) * 1887-08-02 Measure
US494467A (en) * 1893-03-28 Liquid measurer and extractor
FR372392A (en) * 1906-12-11 1907-04-04 Jacques De Boisse Plug gas pressure lubricator
US1009980A (en) * 1911-11-28 Joseph S Leisure Air-pressure cork.
US1651256A (en) * 1927-11-29 davis
US3485060A (en) * 1968-05-16 1969-12-23 Beech Aircraft Corp Livestock branding apparatus
US3630203A (en) * 1969-12-11 1971-12-28 Air Prod & Chem Cryogenic biological apparatus
US3651813A (en) * 1969-10-08 1972-03-28 Brymill Corp Cryosurgical delivery and application of liquefied gas coolant

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US367474A (en) * 1887-08-02 Measure
US494467A (en) * 1893-03-28 Liquid measurer and extractor
US1009980A (en) * 1911-11-28 Joseph S Leisure Air-pressure cork.
US1651256A (en) * 1927-11-29 davis
FR372392A (en) * 1906-12-11 1907-04-04 Jacques De Boisse Plug gas pressure lubricator
US3485060A (en) * 1968-05-16 1969-12-23 Beech Aircraft Corp Livestock branding apparatus
US3651813A (en) * 1969-10-08 1972-03-28 Brymill Corp Cryosurgical delivery and application of liquefied gas coolant
US3630203A (en) * 1969-12-11 1971-12-28 Air Prod & Chem Cryogenic biological apparatus

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Marshall, Principles and Practice of Operative Dentistry, pp. 578 580. J. B. Lippincott Co., Philadelphia and London, 1901. *

Cited By (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971383A (en) * 1974-05-07 1976-07-27 Erbe Elektromedizin Kg Cryogenic surgical instrument
US3889681A (en) * 1974-10-30 1975-06-17 Jack Douglas Waller Cryosurgical spraying apparatus
US4043341A (en) * 1975-12-09 1977-08-23 Tromovitch Theodore A Portable cryosurgical instrument
US4072152A (en) * 1976-02-23 1978-02-07 Linehan John H Orthopedic cryosurgical apparatus
US4116199A (en) * 1976-12-06 1978-09-26 Brymill Corporation Cryosurgical instrument reservoir
US4220154A (en) * 1976-12-11 1980-09-02 Kurt Semm Device for coagulating biological tissue
EP0060480A1 (en) * 1981-03-18 1982-09-22 Messer Griesheim Gmbh Device for handling and dosing small volumes of super-cooled liquids
US5400923A (en) * 1988-06-20 1995-03-28 Helena Laboratories Corporation Apparatus for discharging contents of a sealed container
US5147355A (en) * 1988-09-23 1992-09-15 Brigham And Womens Hospital Cryoablation catheter and method of performing cryoablation
US5108390A (en) * 1988-11-14 1992-04-28 Frigitronics, Inc. Flexible cryoprobe
US5277642A (en) * 1991-12-23 1994-01-11 Dorta Juan F Combination toy and beverage dispensing device
US5474210A (en) * 1992-02-27 1995-12-12 Pump Products, Inc. Fluid dispensing device
US5281215A (en) * 1992-04-16 1994-01-25 Implemed, Inc. Cryogenic catheter
US5423807A (en) * 1992-04-16 1995-06-13 Implemed, Inc. Cryogenic mapping and ablation catheter
US5281213A (en) * 1992-04-16 1994-01-25 Implemed, Inc. Catheter for ice mapping and ablation
US6161543A (en) * 1993-02-22 2000-12-19 Epicor, Inc. Methods of epicardial ablation for creating a lesion around the pulmonary veins
US5415329A (en) * 1993-06-22 1995-05-16 Tosca Limited Container including a pressure relief valve for use in holding and dispensing soft drink material
US5960998A (en) * 1994-08-10 1999-10-05 Brown; Don W. Insulated spray bottle
US7422588B2 (en) 1995-02-22 2008-09-09 Medtronic, Inc. Pen-type electrosurgical instrument
US7794460B2 (en) 1995-02-22 2010-09-14 Medtronic, Inc. Method of ablating tissue
US7247155B2 (en) 1995-02-22 2007-07-24 Medtronic, Inc. Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue
US7166105B2 (en) 1995-02-22 2007-01-23 Medtronic, Inc. Pen-type electrosurgical instrument
US9770282B2 (en) 1995-02-22 2017-09-26 Medtronic, Inc. Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue
US7128740B2 (en) 1996-05-03 2006-10-31 Jacobs Clemens J Method for interrupting conduction paths within the heart
US5846235A (en) * 1997-04-14 1998-12-08 Johns Hopkins University Endoscopic cryospray device
US6383181B1 (en) * 1997-05-23 2002-05-07 Frank Majerowicz Method and apparatus for cryogenic spray ablation of gastrointestinal mucosa
US20070276360A1 (en) * 1997-05-23 2007-11-29 Csa Medical, Inc. Heated catheter used in cryotherapy
US7470272B2 (en) 1997-07-18 2008-12-30 Medtronic, Inc. Device and method for ablating tissue
US7678111B2 (en) 1997-07-18 2010-03-16 Medtronic, Inc. Device and method for ablating tissue
US6035646A (en) * 1998-07-07 2000-03-14 Brymill Corporation Liquid cryogen withdrawal device with pump
US9113896B2 (en) 1998-07-07 2015-08-25 Medtronic, Inc. Method and apparatus for creating a bi-polar virtual electrode used for the ablation of tissue
US20080091194A1 (en) * 1998-07-07 2008-04-17 Mulier Peter M Helical coil apparatus for ablation of tissue
US7169144B2 (en) 1998-07-07 2007-01-30 Medtronic, Inc. Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue
US7699805B2 (en) 1998-07-07 2010-04-20 Medtronic, Inc. Helical coil apparatus for ablation of tissue
US7309325B2 (en) 1998-07-07 2007-12-18 Medtronic, Inc. Helical needle apparatus for creating a virtual electrode used for the ablation of tissue
US7156845B2 (en) 1998-07-07 2007-01-02 Medtronic, Inc. Method and apparatus for creating a bi-polar virtual electrode used for the ablation of tissue
US8221402B2 (en) 2000-01-19 2012-07-17 Medtronic, Inc. Method for guiding a medical device
US7706882B2 (en) 2000-01-19 2010-04-27 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area
US7615015B2 (en) 2000-01-19 2009-11-10 Medtronic, Inc. Focused ultrasound ablation devices having selectively actuatable emitting elements and methods of using the same
US8568409B2 (en) 2000-03-06 2013-10-29 Medtronic Advanced Energy Llc Fluid-assisted medical devices, systems and methods
US9381061B2 (en) 2000-03-06 2016-07-05 Medtronic Advanced Energy Llc Fluid-assisted medical devices, systems and methods
US7435250B2 (en) 2000-04-27 2008-10-14 Medtronic, Inc. Method and apparatus for tissue ablation
US7818039B2 (en) 2000-04-27 2010-10-19 Medtronic, Inc. Suction stabilized epicardial ablation devices
US8162933B2 (en) 2000-04-27 2012-04-24 Medtronic, Inc. Vibration sensitive ablation device and method
US9693819B2 (en) 2000-04-27 2017-07-04 Medtronic, Inc. Vibration sensitive ablation device and method
US6551309B1 (en) 2000-09-14 2003-04-22 Cryoflex, Inc. Dual action cryoprobe and methods of using the same
US7706894B2 (en) 2000-10-10 2010-04-27 Medtronic, Inc. Heart wall ablation/mapping catheter and method
US8706260B2 (en) 2000-10-10 2014-04-22 Medtronic, Inc. Heart wall ablation/mapping catheter and method
US7507235B2 (en) 2001-01-13 2009-03-24 Medtronic, Inc. Method and system for organ positioning and stabilization
US7740623B2 (en) 2001-01-13 2010-06-22 Medtronic, Inc. Devices and methods for interstitial injection of biologic agents into tissue
US7628780B2 (en) 2001-01-13 2009-12-08 Medtronic, Inc. Devices and methods for interstitial injection of biologic agents into tissue
US7824399B2 (en) 2001-04-26 2010-11-02 Medtronic, Inc. Ablation system and method of use
US7250051B2 (en) 2001-04-26 2007-07-31 Medtronic, Inc. Method and apparatus for tissue ablation
US8221415B2 (en) 2001-04-26 2012-07-17 Medtronic, Inc. Method and apparatus for tissue ablation
US7959626B2 (en) 2001-04-26 2011-06-14 Medtronic, Inc. Transmural ablation systems and methods
US20080015562A1 (en) * 2001-04-26 2008-01-17 Medtronic, Inc. Transmural ablation systems and methods
US8512337B2 (en) 2001-04-26 2013-08-20 Medtronic, Inc. Method and system for treatment of atrial tachyarrhythmias
US8262649B2 (en) 2001-04-26 2012-09-11 Medtronic, Inc. Method and apparatus for tissue ablation
US7094235B2 (en) 2001-04-26 2006-08-22 Medtronic, Inc. Method and apparatus for tissue ablation
US7367972B2 (en) 2001-04-26 2008-05-06 Medtronic, Inc. Ablation system
US7250048B2 (en) 2001-04-26 2007-07-31 Medtronic, Inc. Ablation system and method of use
US7347858B2 (en) 2001-12-11 2008-03-25 Medtronic, Inc. Method and system for treatment of atrial tachyarrhythmias
US8623010B2 (en) 2002-01-25 2014-01-07 Medtronic, Inc. Cardiac mapping instrument with shapeable electrode
US7967816B2 (en) 2002-01-25 2011-06-28 Medtronic, Inc. Fluid-assisted electrosurgical instrument with shapeable electrode
US7364578B2 (en) 2002-01-25 2008-04-29 Medtronic, Inc. System and method of performing an electrosurgical procedure
US8414573B2 (en) 2002-05-16 2013-04-09 Medtronic, Inc. Device and method for ablation of cardiac tissue
US7294143B2 (en) 2002-05-16 2007-11-13 Medtronic, Inc. Device and method for ablation of cardiac tissue
US7118566B2 (en) 2002-05-16 2006-10-10 Medtronic, Inc. Device and method for needle-less interstitial injection of fluid for ablation of cardiac tissue
US7975703B2 (en) 2002-05-16 2011-07-12 Medtronic, Inc. Device and method for needle-less interstitial injection of fluid for ablation of cardiac tissue
US7083620B2 (en) 2002-10-30 2006-08-01 Medtronic, Inc. Electrosurgical hemostat
US7963963B2 (en) 2002-10-30 2011-06-21 Medtronic, Inc. Electrosurgical hemostat
US8273072B2 (en) 2003-01-14 2012-09-25 Medtronic, Inc. Devices and methods for interstitial injection of biologic agents into tissue
US7744562B2 (en) 2003-01-14 2010-06-29 Medtronics, Inc. Devices and methods for interstitial injection of biologic agents into tissue
US7497857B2 (en) 2003-04-29 2009-03-03 Medtronic, Inc. Endocardial dispersive electrode for use with a monopolar RF ablation pen
US7871409B2 (en) 2003-04-29 2011-01-18 Medtronic, Inc. Endocardial dispersive electrode for use with a monopolar RF ablation pen
US8333764B2 (en) 2004-05-12 2012-12-18 Medtronic, Inc. Device and method for determining tissue thickness and creating cardiac ablation lesions
US8801707B2 (en) 2004-05-14 2014-08-12 Medtronic, Inc. Method and devices for treating atrial fibrillation by mass ablation
US7758580B2 (en) 2004-06-02 2010-07-20 Medtronic, Inc. Compound bipolar ablation device and method
US7758576B2 (en) 2004-06-02 2010-07-20 Medtronic, Inc. Clamping ablation tool and method
US7875028B2 (en) 2004-06-02 2011-01-25 Medtronic, Inc. Ablation device with jaws
US7566334B2 (en) 2004-06-02 2009-07-28 Medtronic, Inc. Ablation device with jaws
US8172837B2 (en) 2004-06-02 2012-05-08 Medtronic, Inc. Clamping ablation tool and method
US20090270857A1 (en) * 2004-06-02 2009-10-29 Christian Steven C Ablation Device with Jaws
US8162941B2 (en) 2004-06-02 2012-04-24 Medtronic, Inc. Ablation device with jaws
US7678108B2 (en) 2004-06-02 2010-03-16 Medtronic, Inc. Loop ablation apparatus and method
US9656063B2 (en) 2004-06-18 2017-05-23 Medtronic, Inc. Method and system for placement of electrical lead inside heart
US8409219B2 (en) 2004-06-18 2013-04-02 Medtronic, Inc. Method and system for placement of electrical lead inside heart
US8926635B2 (en) 2004-06-18 2015-01-06 Medtronic, Inc. Methods and devices for occlusion of an atrial appendage
US8663245B2 (en) 2004-06-18 2014-03-04 Medtronic, Inc. Device for occlusion of a left atrial appendage
US9227088B2 (en) 2006-05-25 2016-01-05 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
US9724119B2 (en) 2006-05-25 2017-08-08 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
US9931134B2 (en) 2006-05-25 2018-04-03 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
US20090192504A1 (en) * 2008-01-29 2009-07-30 Csa Medical, Inc. Cryosurgery system having unintegrated delivery and visualization apparatus
US8821488B2 (en) 2008-05-13 2014-09-02 Medtronic, Inc. Tissue lesion evaluation
US9486283B2 (en) 2009-02-23 2016-11-08 Medtronic Advanced Energy Llc Fluid-assisted electrosurgical device
US8632533B2 (en) 2009-02-23 2014-01-21 Medtronic Advanced Energy Llc Fluid-assisted electrosurgical device
US8906012B2 (en) 2010-06-30 2014-12-09 Medtronic Advanced Energy Llc Electrosurgical devices with wire electrode
US9974599B2 (en) 2014-08-15 2018-05-22 Medtronic Ps Medical, Inc. Multipurpose electrosurgical device
US20170071530A1 (en) * 2015-09-14 2017-03-16 Gerald KABAN Thermal tooth testing devices, methods and kits

Similar Documents

Publication Publication Date Title
US3532094A (en) Cryogenic-instrument with detachable probe
US3439680A (en) Surgical instrument for cataract removal
US3460538A (en) Hypothermia apparatus and method for treating the human body and the like
US5063753A (en) Apparatus for storing produce
US5117822A (en) Silicone heart spoon
US5899897A (en) Method and apparatus for heating during cryosurgery
US4207897A (en) Cryosurgical probe
US5976505A (en) Method for cryogenically treating psoriasis with liquid nitrogen or liquid nitrous oxide
US4844088A (en) Surgical cutting device with reciprocating cutting member
US5105808A (en) Intrauterine cauterizing method
US3272203A (en) Surgical probe
US5397000A (en) System for confining articles in a container
US5911520A (en) Portable shower apparatus
US20040034339A1 (en) Device for improved visualization of operative sites during surgery
US4766740A (en) Container for the preservation and transportation of severed limbs or other body parts
US3794039A (en) Apparatus for cryosurgery
US6786902B1 (en) Method and apparatus for cryosurgery
US6319248B1 (en) Spray catheter
US5460628A (en) Heated balloon medical apparatus with fluid agitating means
US4215476A (en) Health services combination irrigator and aspirator
US20040078033A1 (en) Cryosurgical instrument and its accessory system
US5254116A (en) Cryosurgical instrument with vent holes and method using same
US5419772A (en) Surgical irrigation apparatus for cleaning and sterilizing wounds and surgical areas during surgery
US5156009A (en) Method for storing produce
US4474016A (en) Sterile cooling system