US3790507A - Plastic bone composition - Google Patents

Plastic bone composition Download PDF

Info

Publication number
US3790507A
US3790507A US3790507DA US3790507A US 3790507 A US3790507 A US 3790507A US 3790507D A US3790507D A US 3790507DA US 3790507 A US3790507 A US 3790507A
Authority
US
Grant status
Grant
Patent type
Prior art keywords
bone
composition
implant
coating
plastic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
M Hodosh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp
Original Assignee
Research Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02Polyalkylene oxides
    • C08L71/03Polyepihalohydrins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61CDENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61CDENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0018Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
    • A61C8/0028Pins, needles; Head structures therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/28Bones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S606/00Surgery
    • Y10S606/907Composed of particular material or coated

Abstract

A COMPOSITION COMPRISING AS ITS BASIC INGREDIENTS A MIXTURE OF GRATED ANORGANIC BONE AND AN ACRYLIC POLYMER, SUCH AS POLYMETHACRYLATE, FOR USE AS DENTAL IMPLANTS, AS WELL AS FOR IMPLANTS IN OTHER PARTS OF THE BODY, AND AS A COATING FOR METALS WHICH MAY BY IMPLANTED IN THE HUMAN BODY FOR DENTAL PURPOSES, ORTHOPEDIC PROTHESES, NEUROSURGERY AND OTHERS.

Description

Feb. 5, M HODQSH PLASTiC BONE COMPOSITiON Original Filed March 10. 1969 F l G. 3

F l G. l

F I G. 7

United States Patent 3,790,507 PLASTIC BONE CONIPOSITION Milton Hodosh, Providence, R.I., assignor to Research Corporation, New York, N.Y.

Original application Mar. 10, 1969, Ser. No. 805,400, now Patent No. 3,609,867, dated Oct. 5, 1971. Divided and this application July 6, 1970, Ser. No. 60,983

Int. Cl. C08f 45/04, 47/10 U.S. Cl. 260-2.5 R 4 Claims ABSTRACT OF THE DISCLOSURE A composition comprising as its basic ingredients a mixture of grated anorganic bone and an acrylic polymer, such as polymethacrylate, for use as dental implants, as well as for implants in other parts of the body, and as a coating for metals which may be implanted in the human body for dental purposes, orthopedic protheses, neurosurgery and others.

BACKGROUND OF THE INVENTION This is a division of application Ser. No. 805,400, filed Mar. 10, 1969, now U.S. Pat. No. 3,609,867.

It is well known in the dental art to utilize an acrylic polymer, such as polymethacrylate, for example, in the making of denture bases, and, also artificial implants have heretofore been made of this material. These acrylic polymers have many characteristics that make them highly desirable for use as an artificial implant, which characteristics include the fact that this plastic material ap proaches a natural tooth in hardness and rigidity, is not adversely affected by the temperature conditions normally encountered in the human mouth, can be worked with facility to any desired shape, retains its color and composition, etc. Perhaps of even greater importance is the fact that it has been found that when an acrylic polymer is used for an artificial tooth replica implant a periodontal membrane forms around the base of the artificial implant much like that which exists around a natural tooth. This periodontal membrane is the structure that acts as a shock absorber, infection limiting mechanism and as a cellular reservoir, and the presence of such a membrane in an artificial implant is extremely important and desirable. It has been found that the membrane which forms about the acrylic polymer artificial implant distributes the forces exerted to the supporting tissues of the tooth in a nearnatural manner.

One of the problems that has existed in connection with acrylic polymer dental implants is the fact that the fibrous interlock between the artificial implant and its periodontal membrane is not as deep and penetrating as that which exists with a natural tooth, nor is the pattern of interlock the same. The instant invention overcomes this deficiency and achieves a more effective interlock by more closely approaching the interlock which exists with a natural tooth, thus forming a more healthy periodontal membrane and a more firm and secure mounting of the artificial implant in the alveolar socket.

The instant invention also has utility in overcoming certain disadvantages that exist where metal implants are used in the human body. Metal implants have traditionally been used for dental purposes, as well as in the field of orthopedics and neurosourgery, and one of the problems that exist in such metal implants is the fact that metals have corrosive actions in the presence of living tissues resulting in electrolytic currents being emitted which in turn results in resorptive and destructive phenomena. It is, therefore, desirable to coat such metallic implants 'with the plastic bone composition of the instant invention since, once so coated, the implant is resistant to abrasion and corrosion and hence is non-conductive of the aforeice said electrolytic currents. In addition, the plastic bone coating results in a better fibrous interlock between the metallic implant and the surrounding bone in a biologically acceptable manner.

SUMMARY OF THE INVENTION It is therefore a primary object of the instant invention to provide a composition of matter for use as an implant in the human body wherein the implant is biologically accepted by the surrounding tissues and interlocks therewith in a firm and natural manner.

A further object is the provision of a composition which may be used in the formation of an artificial dental implant, said composition being such that When the artificial implant is mounted in an alveolar socket, a periodontal membrane will form about the roots of the implant much like the membrane which exists around the roots of a natural tooth.

Another object is the provision of a plastic bone composition that may be used as a coating for metal implants.

Still another object is the provision of a plastic bone composition that is structurally strong but yet has sulficient porosity to enable implants or inserts of said composition in the human body to effectively interlock with surrounding bone and other tissues.

DESCRIPTION OF THE DRAWINGS In the drawings which illustrate the best mode presently contemplated for carrying out the present invention:

FIG. 1 is an elevational view of an artificial tooth constructed and mounted in accordance with the instant invention;

FIG. 2 is a top plan view of the supporting struts;

FIG. 3 is a section taken on line 3-3 of FIG. 2;

FIG. 4 is a section taken on line 44 of FIG. 2;

FIG. 5 is a detailed perspective of one of the supporting struts prior to being coated;

FIG. 6 is a detiled perspective of the strut shown in FIG. 5 after coating; and

FIG. 7 is a section taken on line 77 of FIG. 6.

DESCRIPTION OF THE INVENTION In carrying out the aforestated objectives, a composition has been provided comprising as its basic ingredients a mixture of an acrylic polymer and anorganic bone. The bone is grated or ground to powder form and then mixed with the polymer, which may be either a heat process or quick-setting plastic. Any suitable bone may be used, although in practice it has been found that Boplant (registered trademark of Squibb) and Kiel Bone (trademark of Unilab Surgicals) have proven to be highly satisfactory. Boplant and Kiel Bone are sterile processed, bovine bone or cartrilage commonly used for grafting procedures in orthopedic and reconstructive surgery. The plastic may be polymethacrylate, polymethylmethacrylate, or any other acrylic polymer having substantially the same characteristics.

The acrylic polymer in the above mixture imparts rigidity and strength to the composition, wherein its architectural shape is maintained; and, as previously mentioned, acr'ylic polymer, such as polyrnethacrylate, has substantially the strength, color, stability, and temperature characteristics exhibited by natural teeth which, of course, are of extreme importance when the instant composition is used as an artificial dental implant. On the other hand, the anorganic bone in the mixture is degrading and resorptive, thus imparting additional porosity to the composition. Thus, the composition becomes more porous as resorption of the bone takes place.

Since the composition of the instant invention has been developed for use as a dental implant and for implanting in other parts of the body as well, it is obviously importaut that the proper proportion of bone and plastic be employed in the mixture. To this end it has been found that when the bone comprises more than 30 percent by weight of the mixture, immunological rejection phenomenom begins to appear. When, however, less than 30 percent by weight of bone is in the mixture, then the heterograft reaction that is found when bone from one animal is implanted into another animal is absent; and, accordingly, this composition of this invention comprises a maximum of 30 percent by weight of bone in the mixture. On the other hand, it is desirable that there be sufiicient bone in the mixture so that the desired porosity will exist in the composition, and, hence, it has been found that a mixture comprising 20 percent to 22. percent by Weight of bone and 78 percent to 80 percent by weight of acrylic polymer provides the best results.

Additional porosity may be obtained by the use of foaming agents in the mixture, not to exceed percent of the mixture by weight.

The compositions above described have the quality of enabling connective tissue fibers to penetrate and form an actual network within its structure, thus bonding or uniting to its host in a biologically acceptable manner. As previously stated, it is the resorption of the bone in the mixture that creates the porosity that permits the aforesaid fibrous interlock to take place.

When these compositions are used as an artificial dental implant, the teeth replica implant is placed in the existing alveolar socket as soon after extraction of the natural tooth as possible. As previously stated, an artificial dental implant constructed of my composition has the highly desirable feature of forming a periodental membrane much like that which exists with a natural tooth. It should be noted, however, that this composition is not limited to use as a dental implant but rather may be used as a substitute for human tissue wherever necessary and desirable, such as to fill defects or holes in the brain, skull or the like. Expressed ditferently, my composition. may be used as a replacement for depleted bone throughout the body, such as in cranioplastics and cysts. In addition, this composition is highly desirable for use as a. coating material for metals that are used throughout the body for orthopedic prothesis.

Referring to the drawings, there is shown in FIGS. 14 an artificial tooth crown 10 and mounted in the gum 12 by means of metallic pins or struts shown generally at 14. As will be seen most clearly in FIGS. 5-7, each pin 14 comprises an enlarged point at front end 16, an enlarged cylindrical rear end 18 and a reduced shaft portion 20 extending therebetween. The shaft portion 20 is provided with a plurality of notches 22 for promoting a stronger bond between the reduced shaft portion 20 and coating 24 which extends therearound. The coating 24 consists of the plastic bone composition of the instant invention, and it will be noted that the coating is substantially flush with enlarged portions 16 and 18. One of the desirable features of the plastic bone composition of the instant invention is the fact that it has the capacity and ability of bonding firmly to metals, although, as aforestated, the secureness of the bond is enhanced by the provision of the notches 22. The pin 14 may be of any desired metal,

although when used as a dental implant, it has been found that vitallium is desirable and satisfactory. Also, it is possible to completely coat a pin similar to pin 14,

in which event it would not be necessary to have reduced shaft portion 20.

As will be seen most clearly in FIGS. 24, three pins 14 are provided, said pins being inserted into specially provided bores in bone 26 so that the non-coated portion 18 of the pins 14 is above the upper surface of the gingiva 28 and is embedded within the crown 10. The struts 14 diverge from crown 10 in a tripod arrangement so as to provide a firm mounting for the crown, although other supporting arrangements could obviously be used.

The presence of coating 24 is advantageous for a num ber of reasons. As previously stated, the porosity of the plastic bone composition which makes up the coating 24 results in a better fibrous interlock between the coating and the surrounding periodental tissues. In addition, the presence of coating 24 prevents the usual corrosive action which takes place when metals are in the presence of living tissues. Thus, the presence of coating 24 prevents emission of microwaves of electrolytic current and the resorptive and destructive phenomenom which results therefrom. Also, the presence of coating results in minimal inflammation and excellent giugival health.

Although the use of the instant invention as a coating for a metallic pin used for dental purposes has been illustrated and described, it will be understood that other metallic implants and inserts in the human body will likewise benefit from the presence of a coating of this this plastic bone composition. Thus, digits and limbs may be made from a combination of metals having this plastic bone coating. These may surgically ha ve ligamentous attachments, and movements may be effected by bioengineering aids.

What is claimed is:

1. A plastic bone composition consisting essentially of grated anorganic bone and polymethylmethacrylate, there being sufficient bone in the mixture to substantially increase the porosity thereof, but the proportion of said bone in the mixture not exceeding 30% by Weight.

2. The composition of claim 1 containing 20 to 22 percent by weight of grated anorganic bone and 78 to 80 percent by weight of polymethylmethacrylate.

3. The composition of claim 1 additionally containing approximately 10 percent by weight of a foaming agent.

4. The composition of claim 1 in combination with a metal member, said composition being in the form of a coating cover said member.

References Cited UNITED STATES PATENTS 3,390,456 7/ 1968 Delava 106-35 3,469,317 9/1969 Jarby 10635 2,968,593 1/1961 Rapkin 128-1 R FOREIGN PATENTS 718,685 '1 l/'4 Great Britain 32-10 OTHER REFERENCES Experiments Suggest Man Might Grow a New Hearth, Washington Sunday Post, Sept. 22, 1968.

WILBERT J. BRIGGS, 8a., Primary Examiner US. Cl. X.R.

US3790507A 1969-03-10 1970-07-06 Plastic bone composition Expired - Lifetime US3790507A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US80540069 true 1969-03-10 1969-03-10
US6098370 true 1970-07-06 1970-07-06

Publications (1)

Publication Number Publication Date
US3790507A true US3790507A (en) 1974-02-05

Family

ID=26740605

Family Applications (1)

Application Number Title Priority Date Filing Date
US3790507A Expired - Lifetime US3790507A (en) 1969-03-10 1970-07-06 Plastic bone composition

Country Status (1)

Country Link
US (1) US3790507A (en)

Cited By (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3892648A (en) * 1974-04-16 1975-07-01 Us Navy Electrochemical deposition of bone
US3906550A (en) * 1973-12-27 1975-09-23 William Rostoker Prosthetic device having a porous fiber metal structure
US3918100A (en) * 1974-05-13 1975-11-11 Us Navy Sputtering of bone on prostheses
US3955280A (en) * 1972-10-18 1976-05-11 Meer Sneer Dental implants
US3986212A (en) * 1975-04-11 1976-10-19 Glasrock Products, Inc. Composite prosthetic device with porous polymeric coating
FR2350827A1 (en) * 1976-05-12 1977-12-09 Battelle Institut E V An subject of dental STENT anchor a major effort and process for its manufacture
US4146936A (en) * 1975-12-30 1979-04-03 Sumitomo Chemical Company Limited Implants for bones, joints and tooth roots
US4199864A (en) * 1975-12-22 1980-04-29 Arthur Ashman Endosseous plastic implant method
WO1981000670A1 (en) * 1979-09-10 1981-03-19 Massachusetts Inst Technology Pre-coated body implant
US4279598A (en) * 1976-07-06 1981-07-21 Scheicher Hans M F Dental half-implants
US4281420A (en) * 1979-02-15 1981-08-04 Raab S Bone connective prostheses adapted to maximize strength and durability of prostheses-bone cement interface; and methods of forming same
US4291013A (en) * 1978-10-09 1981-09-22 Merck Patent Gesellschaft Mit Beschrankter Haftung Medicinally useful, shaped mass of collagen resorbable in the body
US4314380A (en) * 1980-09-26 1982-02-09 Koken Co., Ltd. Artificial bone
US4322398A (en) * 1978-02-20 1982-03-30 Battelle Institut E.V. Implantable drug depot and process for the production thereof
US4365359A (en) * 1979-02-15 1982-12-28 Raab S PMMA Coated bone connective prostheses and method of forming same
US4501031A (en) * 1981-01-22 1985-02-26 Zimmer, Inc. Metal and plastic composite tibial component for knee joint
US4585458A (en) * 1981-06-10 1986-04-29 Kurland Kenneth Z Means and method of implanting bioprosthetics
US4778388A (en) * 1986-11-07 1988-10-18 Sankin Kogyo Kabushiki Kaisha Root canal posts
WO1989000410A1 (en) * 1987-07-15 1989-01-26 Team, Inc. Improved dental implant and method
US4888018A (en) * 1988-12-27 1989-12-19 Giampapa Vincent C Method of positioning and securing a chin implant
US4990090A (en) * 1988-11-18 1991-02-05 Roane James B Endodontic post construction
US5122132A (en) * 1991-08-01 1992-06-16 Bremer Medical, Inc. Skull pin with enhanced shear resistance
US5643268A (en) * 1994-09-27 1997-07-01 Brainlab Med. Computersysteme Gmbh Fixation pin for fixing a reference system to bony structures
US5816811A (en) * 1993-11-10 1998-10-06 Implant Innovations, Inc. Surgically implantable prosthetic devices
US5899939A (en) * 1998-01-21 1999-05-04 Osteotech, Inc. Bone-derived implant for load-supporting applications
US6123731A (en) * 1998-02-06 2000-09-26 Osteotech, Inc. Osteoimplant and method for its manufacture
US6258091B1 (en) 1996-02-14 2001-07-10 Walter Lorenz Surgical Inc. Bone fastener and instrument for insertion thereof
US6270500B1 (en) 1996-02-03 2001-08-07 Karl-Dieter Lerch Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation
US6334891B1 (en) 1992-10-16 2002-01-01 Norian Corporation Paste compositions capable of setting into carbonated apatite
US6379363B1 (en) 1999-09-24 2002-04-30 Walter Lorenz Surgical, Inc. Method and apparatus for reattachment of a cranial flap using a cranial clamp
US6491723B1 (en) 1996-02-27 2002-12-10 Implant Innovations, Inc. Implant surface preparation method
US20030009235A1 (en) * 2000-07-19 2003-01-09 Albert Manrique Osteoimplant and method of making same
US20030130736A1 (en) * 2001-10-24 2003-07-10 Simon Raab Bone connective prosthesis and method of forming same
US6652765B1 (en) 1994-11-30 2003-11-25 Implant Innovations, Inc. Implant surface preparation
US6685707B2 (en) 2001-09-25 2004-02-03 Walter Lorenz Surgical, Inc. Cranial clamp and method for fixating a bone plate
US20040265780A1 (en) * 2003-05-16 2004-12-30 Robb T. Tait Surface treatment process for implants made of titanium alloy
US20070000802A1 (en) * 2005-06-21 2007-01-04 Cervitech, Inc. Holder for intervertebral prostheses
US20070088437A1 (en) * 2003-06-11 2007-04-19 Betz Randal R Osteoimplants and methods for their manufacture
US20070108162A1 (en) * 1994-11-30 2007-05-17 Beaty Keith D Implant surface preparation
US20080063671A1 (en) * 2005-11-02 2008-03-13 Morris John W Hemostatic bone graft
US20080145392A1 (en) * 2001-10-12 2008-06-19 David Knaack Bone Graft
US20090062798A1 (en) * 2006-11-06 2009-03-05 Janet Conway Internal bone transport
US20100055646A1 (en) * 2007-04-12 2010-03-04 Daguo Zhao Bionic dental implant
US20100239634A1 (en) * 2008-10-24 2010-09-23 Shimp Lawrence A Compositions and methods for promoting bone formation
US7939108B2 (en) 2000-12-14 2011-05-10 Osteotech, Inc. Method of making demineralized bone particles
US8002813B2 (en) 1999-10-15 2011-08-23 Warsaw Orthopedic, Inc. Volume maintaining osteoinductive/osteoconductive compositions
US8221499B2 (en) 1994-11-30 2012-07-17 Biomet 3I, Llc Infection-blocking dental implant
US9289275B2 (en) 2010-10-21 2016-03-22 Daguo Zhao Bionic tooth implant, and base and sub-root thereof

Cited By (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3955280A (en) * 1972-10-18 1976-05-11 Meer Sneer Dental implants
US3906550A (en) * 1973-12-27 1975-09-23 William Rostoker Prosthetic device having a porous fiber metal structure
US3892648A (en) * 1974-04-16 1975-07-01 Us Navy Electrochemical deposition of bone
US3918100A (en) * 1974-05-13 1975-11-11 Us Navy Sputtering of bone on prostheses
US3986212A (en) * 1975-04-11 1976-10-19 Glasrock Products, Inc. Composite prosthetic device with porous polymeric coating
US4199864A (en) * 1975-12-22 1980-04-29 Arthur Ashman Endosseous plastic implant method
US4146936A (en) * 1975-12-30 1979-04-03 Sumitomo Chemical Company Limited Implants for bones, joints and tooth roots
FR2350827A1 (en) * 1976-05-12 1977-12-09 Battelle Institut E V An subject of dental STENT anchor a major effort and process for its manufacture
US4202055A (en) * 1976-05-12 1980-05-13 Battelle-Institut E.V. Anchorage for highly stressed endoprostheses
US4279598A (en) * 1976-07-06 1981-07-21 Scheicher Hans M F Dental half-implants
US4347234A (en) * 1978-01-09 1982-08-31 Merck Patent Gesellschaft Mit Beschrankter Haftung Medicinally useful, shaped mass of collagen resorbable in the body
US4322398A (en) * 1978-02-20 1982-03-30 Battelle Institut E.V. Implantable drug depot and process for the production thereof
US4291013A (en) * 1978-10-09 1981-09-22 Merck Patent Gesellschaft Mit Beschrankter Haftung Medicinally useful, shaped mass of collagen resorbable in the body
US4281420A (en) * 1979-02-15 1981-08-04 Raab S Bone connective prostheses adapted to maximize strength and durability of prostheses-bone cement interface; and methods of forming same
US4365359A (en) * 1979-02-15 1982-12-28 Raab S PMMA Coated bone connective prostheses and method of forming same
US4336618A (en) * 1979-02-15 1982-06-29 Raab S Bone connective prostheses adapted to maximize strength and durability of prostheses-bone cement interface; and methods of forming same
WO1981000670A1 (en) * 1979-09-10 1981-03-19 Massachusetts Inst Technology Pre-coated body implant
US4283799A (en) * 1979-09-10 1981-08-18 Massachusetts Institute Of Technology Pre-coated body implant
US4314380A (en) * 1980-09-26 1982-02-09 Koken Co., Ltd. Artificial bone
US4501031A (en) * 1981-01-22 1985-02-26 Zimmer, Inc. Metal and plastic composite tibial component for knee joint
US4585458A (en) * 1981-06-10 1986-04-29 Kurland Kenneth Z Means and method of implanting bioprosthetics
US4778388A (en) * 1986-11-07 1988-10-18 Sankin Kogyo Kabushiki Kaisha Root canal posts
WO1989000410A1 (en) * 1987-07-15 1989-01-26 Team, Inc. Improved dental implant and method
US4872840A (en) * 1987-07-15 1989-10-10 Team Incorporated Dental implant and method
US4990090A (en) * 1988-11-18 1991-02-05 Roane James B Endodontic post construction
US4888018A (en) * 1988-12-27 1989-12-19 Giampapa Vincent C Method of positioning and securing a chin implant
US5122132A (en) * 1991-08-01 1992-06-16 Bremer Medical, Inc. Skull pin with enhanced shear resistance
US6334891B1 (en) 1992-10-16 2002-01-01 Norian Corporation Paste compositions capable of setting into carbonated apatite
US5816811A (en) * 1993-11-10 1998-10-06 Implant Innovations, Inc. Surgically implantable prosthetic devices
US5643268A (en) * 1994-09-27 1997-07-01 Brainlab Med. Computersysteme Gmbh Fixation pin for fixing a reference system to bony structures
US7857987B2 (en) 1994-11-30 2010-12-28 Biomet 3I, Llc Implant surface preparation
US8221499B2 (en) 1994-11-30 2012-07-17 Biomet 3I, Llc Infection-blocking dental implant
US20040148031A1 (en) * 1994-11-30 2004-07-29 Beaty Keith D. Implant surface preparation
US20070108162A1 (en) * 1994-11-30 2007-05-17 Beaty Keith D Implant surface preparation
US20080135521A1 (en) * 1994-11-30 2008-06-12 Beaty Keith D Implant surface preparation
US7547399B2 (en) 1994-11-30 2009-06-16 Biomet 3I, Llc Implant surface preparation
US7550091B2 (en) 1994-11-30 2009-06-23 Biomet 3I, Llc Implant surface preparation
US20080160168A1 (en) * 1994-11-30 2008-07-03 Beaty Keith D Implant surface preparation
US7169317B2 (en) 1994-11-30 2007-01-30 Implant Innovations, Inc. Implant surface preparation
US6652765B1 (en) 1994-11-30 2003-11-25 Implant Innovations, Inc. Implant surface preparation
US6969474B2 (en) 1994-11-30 2005-11-29 Implant Innovations, Inc. Implant surface preparation
US6962591B2 (en) 1996-02-03 2005-11-08 Karl-Dieter Lerch Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation
US6726688B2 (en) 1996-02-03 2004-04-27 Karl-Dieter Lerch Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation
US6328743B2 (en) 1996-02-03 2001-12-11 Karl-Dieter Lerch Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation
US6270500B1 (en) 1996-02-03 2001-08-07 Karl-Dieter Lerch Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation
US20040172029A1 (en) * 1996-02-03 2004-09-02 Karl-Dieter Lerch Device for postoperative fixation back into the cranium of a plug of bone removed therefrom during a surgical operation
US6589244B1 (en) 1996-02-14 2003-07-08 Walter Lorenz Surgical, Inc. Bone fastener and instrument for insertion thereof
US6258091B1 (en) 1996-02-14 2001-07-10 Walter Lorenz Surgical Inc. Bone fastener and instrument for insertion thereof
US6491723B1 (en) 1996-02-27 2002-12-10 Implant Innovations, Inc. Implant surface preparation method
US5899939A (en) * 1998-01-21 1999-05-04 Osteotech, Inc. Bone-derived implant for load-supporting applications
US6843807B1 (en) 1998-02-06 2005-01-18 Osteotech Inc. Osteoimplant
US6123731A (en) * 1998-02-06 2000-09-26 Osteotech, Inc. Osteoimplant and method for its manufacture
US6294041B1 (en) 1998-02-06 2001-09-25 Osteotech, Inc. Method for an osteoimplant manufacture
US6379363B1 (en) 1999-09-24 2002-04-30 Walter Lorenz Surgical, Inc. Method and apparatus for reattachment of a cranial flap using a cranial clamp
US8002813B2 (en) 1999-10-15 2011-08-23 Warsaw Orthopedic, Inc. Volume maintaining osteoinductive/osteoconductive compositions
US8197474B2 (en) 1999-10-15 2012-06-12 Warsaw Orthopedic, Inc. Volume maintaining osteoinductive/osteoconductive compositions
US9387094B2 (en) 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
US20030009235A1 (en) * 2000-07-19 2003-01-09 Albert Manrique Osteoimplant and method of making same
US8663672B2 (en) 2000-07-19 2014-03-04 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
US20060030948A1 (en) * 2000-07-19 2006-02-09 Albert Manrique Osteoimplant and method of making same
US20110108644A1 (en) * 2000-12-14 2011-05-12 Morris John W Method of Making Demineralized Bone Particles
US7939108B2 (en) 2000-12-14 2011-05-10 Osteotech, Inc. Method of making demineralized bone particles
US8529962B2 (en) 2000-12-14 2013-09-10 Warsaw Orthopedic, Inc. Method of making demineralized bone particles
US20040127908A1 (en) * 2001-09-25 2004-07-01 Roman Shawn David Cranial clamp with torque-limiting feature
US6685707B2 (en) 2001-09-25 2004-02-03 Walter Lorenz Surgical, Inc. Cranial clamp and method for fixating a bone plate
US20080145392A1 (en) * 2001-10-12 2008-06-19 David Knaack Bone Graft
US7959941B2 (en) 2001-10-12 2011-06-14 Warsaw Orthopedic, Inc. Bone graft comprising a demineralized bone matrix and a stabilizing agent
US20030130736A1 (en) * 2001-10-24 2003-07-10 Simon Raab Bone connective prosthesis and method of forming same
US6984236B2 (en) 2001-10-24 2006-01-10 Faro Technologies, Inc. Bone connective prosthesis and method of forming same
US8753689B2 (en) 2001-12-14 2014-06-17 Warsaw Orthopedic, Inc. Method of making demineralized bone particles
US8251700B2 (en) 2003-05-16 2012-08-28 Biomet 3I, Llc Surface treatment process for implants made of titanium alloy
US20040265780A1 (en) * 2003-05-16 2004-12-30 Robb T. Tait Surface treatment process for implants made of titanium alloy
US20070088437A1 (en) * 2003-06-11 2007-04-19 Betz Randal R Osteoimplants and methods for their manufacture
US8268008B2 (en) 2003-06-11 2012-09-18 Warsaw Orthopedic, Inc. Osteoimplants and methods for their manufacture
US9393116B2 (en) 2003-06-11 2016-07-19 Warsaw Orthopedic, Inc. Osteoimplants and methods for their manufacture
US20070000802A1 (en) * 2005-06-21 2007-01-04 Cervitech, Inc. Holder for intervertebral prostheses
US20080063671A1 (en) * 2005-11-02 2008-03-13 Morris John W Hemostatic bone graft
US8545864B2 (en) 2005-11-02 2013-10-01 Warsaw Orthopedic, Inc. Hemostatic bone graft
US8043299B2 (en) * 2006-11-06 2011-10-25 Janet Conway Internal bone transport
US20090062798A1 (en) * 2006-11-06 2009-03-05 Janet Conway Internal bone transport
US20100055646A1 (en) * 2007-04-12 2010-03-04 Daguo Zhao Bionic dental implant
US8333591B2 (en) * 2007-04-12 2012-12-18 Daguo Zhao Bionic dental implant
US8722075B2 (en) 2008-10-24 2014-05-13 Warsaw Orthopedic, Inc. Compositions and methods for promoting bone formation
US20100239634A1 (en) * 2008-10-24 2010-09-23 Shimp Lawrence A Compositions and methods for promoting bone formation
US9289275B2 (en) 2010-10-21 2016-03-22 Daguo Zhao Bionic tooth implant, and base and sub-root thereof

Similar Documents

Publication Publication Date Title
Brunski Biomaterials and biomechanics in dental implant design.
de Groot Bioceramics consisting of calcium phosphate salts
Denissen et al. Immediate dental root implants from synthetic dense calcium hydroxylapatite
Kato et al. Bonding of alkali‐and heat‐treated tantalum implants to bone
Gould et al. Ultrastructural study of the attachment of human gingiva to titanium in vivo
US5769897A (en) Synthetic bone
US6143036A (en) Bone augmentation for prosthetic implants and the like
Simske et al. Porous materials for bone engineering
Masuda et al. Generalizations regarding the process and phenomenon of osseointegration. Part I. In vivo studies.
Bobyn et al. Characteristics of bone ingrowth and interface mechanics of a new porous tantalum biomaterial
Dubok Bioceramics―yesterday, today, tomorrow
US2347567A (en) Dental implant
US3808606A (en) Bone implant with porous exterior surface
US5522896A (en) Biocompatible composite material
US4693721A (en) Porous flexible metal fiber material for surgical implantation
Van Blitterswijk et al. Macropore tissue ingrowth: a quantitative and qualitative study on hydroxyapatite ceramic
Dorozhkin Bioceramics of calcium orthophosphates
Wnek et al. Encyclopedia of biomaterials and biomedical engineering
LeGeros Properties of osteoconductive biomaterials: calcium phosphates.
Dutton Coralline hydroxyapatite as an ocular implant
US3855638A (en) Surgical prosthetic device with porous metal coating
US3843975A (en) Prosthesis for femoral shaft
US6018095A (en) Method for preparing an implantable composite material, resulting material, implant including said material, and kit therefor
Piecuch et al. Experimental ridge augmentation with porous hydroxyapatite implants
US3919773A (en) Direct moldable implant material