Connect public, paid and private patent data with Google Patents Public Datasets

Implantable spiral wound stimulation electrodes

Download PDF

Info

Publication number
US3760812A
US3760812A US3760812DA US3760812A US 3760812 A US3760812 A US 3760812A US 3760812D A US3760812D A US 3760812DA US 3760812 A US3760812 A US 3760812A
Authority
US
Grant status
Grant
Patent type
Prior art keywords
electrode
conductors
electrical
stimulation
wound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
G Timm
W Bradley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Minnesota
Original Assignee
University of Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode

Abstract

Electrical stimulation electrodes for implantation within a living body for transmission of stimuli to excitable neural or contractile cells. The electrodes are characterized by flexibility to permit following of contour variations and maintenance of electrical contact with the stimulation region. The electrodes include a pair of parallel spaced apart helically wound conductors maintained in this configuration. When the electrode is implanted, undesired excitation of nearby structures can be avoided.

Description

United States Patent 1 1 Timm et al.

[451 Sept. 25, 1973 1 1 IMPLANTABLE SPIRAL WOUND STIMULATION ELECTRODES [75] Inventors: Gerald W. Timm; William E.

Bradley, both of Minneapolis, Minn.

[73] Assignee: The Regents of the University of Minnesota, Minneapolis, Minn.

[22] Filed: Mar. 19, 1971 [21] Appl. No.: 126,145

[52] US. Cl. 128/418, 128/419 E, 174/113 C, 174/130 [51] Int. Cl A6111 1/04 [58] Field of Search 128/404, 416, 418, 128/419 E; 174/113 C, 130

{56] References Cited UNITED STATES PATENTS 3,474,791 10/1969 Bentov 128/418 3,453,374 7/1969 Natwick 174/113 C 3,035,583 5/1962 Hirsch et al. 128/418 3,572,344 3/1971 Bolduc .1 128/418 Primary Examiner-William E. Kamm Attorney-Burd, Braddock & Bartz [57] ABSTRACT Electrical stimulation electrodes for implantation within a living body for transmission of stimuli to excitable neural or contractile cells. The electrodes are characterized by flexibility to permit following of contour variations and maintenance of electrical contact with the stimulation region. The electrodes include a pair of parallel spaced apart helically wound conductors maintained in this configuration. When the electrode is implanted, undesired excitation of nearby structures can be avoided.

10 Claims, 5 Drawing lFigures IMPLANTABLE SPIRAL WOUND STIMULATION ELECTRODES The invention described herein was made in the course of work under a grant or award from the Department of Health, Education and Welfare.

This invention relates to implantable stimulation electrodes for the application in a living body of a current of sufficient magnitude in proximity of any desired excitable neural or contractile cells to activate those neural or contractile cells in the immediate vicinity of the electrode while avoiding excitation of nearby structures. Although not limited thereto, the electrodes are useful in bladder stimulation systems, of which those disclosed in the patents of co-inventor William E.

Bradley, US. Pat. No. 3,236,240 and No. 3,543,761,

are exemplary.

Previous stimulation electrodes have included single or concentric disc electrodes which are characterized by a lack of mechanical flexibility which often causes them to lose electrical contact with the stimulation region. Grid or mesh electrodes have electrical characteristics which require the use of a backing sheet of insulative material which cause the electrode to give unidirectional stimulation. Such electrodes have the further disadvantage that any large sheet covering a contractile organ in the body causes a massive fibrotic reaction that ultimately impairs the organs contractile ability. Prior art electrodes have had the further disadvantage of induction of wide current fields which stimulate contiguous structures in an undesirable manner.

The electrode according to the present invention is flexible such that it can follow contour variations in an organ without interfering with the organs normal contractile function. The electrode may be embedded in the wall of the organ so that'only neural and contractile cells located within this wall will be excited when electrical stimuli are appliedfThe electrode is characterized by two parallel conducting wires extending in a helical fashion and maintained in this configuration.

The invention is illustrated in the accompanying drawings in which:

FIG. 1 is a diagrammatic illustration of one form of spiral wound electrode with insulating core material;

FIG. 2 is a similardiagrammatic illustration showing the approximate volume of tissue which is stimulated by a stimulus applied in the use of the electrode;

FIGS. 3 and 4 are diagrammatic illustrations of the steps of an imbrication technique for embedding the electrode in tissue to be electrically stimulated; and

FIG. 5 is an illustration of an alternative form of electrode in whichconductor wires are interwoven with insulative spacing and supporting strands.

Referring to FIG. 1, the electrode, indicated generally at 10, is comprised of two parallel conducting wires 11 and 12 wrapped helically around a flexible cylindrical insulative core 13. Current flow between conductors l1 and 12 is provided through the tissue in which the electrodes are embedded. The lead-in conductors 15 and 16 are insulated by flexible insulative tubes 17 and 18, respectively, between the source of electrical stimuli and the body situs to be stimulated by the electrode. By using a small diameter core, between about 1 to 3 millimeters, and varying the spacing between the two wires, the field confining properties of the electrode can be varied.

' The spatial relationship between conductors 11 and 12 may be maintained by providing core 13 with shallow spiral channels or grooves in which the conductors are wound; or the conductors may be secured by means of adhesive material, such as medical grade Silastic adhesive; or the conductor may be produced by printed circuit techniques.

The flexibility of the electrode configuration is determined by the mechanical properties of the core and of the wires. The wire can be any implantable electrical current conductor, such as stainless steel, platinum or one of its alloys, such as platinum-irridium, carbon impregnated polyester (Dacron), or the like. The insulating core is typically made from implantable grade silicone rubber, nylon, silk, or other implantable insulating material. The insulating tubes 17 and 18 for the lead-in wires are typically implantable silastic or polytetrafluoroethylene (Teflon) tubing.

As seen in broken lines in FIG. 2, experimentation has shown that stimulus is effective within a volume described by a cylinder 20 concentric to the electrode 10, the diameter of the cylinder being equal to the diameter D of the electrode plus twice the spacing 5 between the helical wires (D 28) and with a height or length equal to the electrode length L plus the cylinder diameter (L D 25). As a general rule, the best confining properties of the electrode are achieved when the spacing S between parallel wires 11 and 12 approximately equals the diameter D of the electrode. For example, to stimulate the nerve net supplying the intestine or urinary bladder, the electrodes were made with the spacing between the conductors and diameter equal, and between about I and 3 millimeters. Stimuli were completely confined to the intestinal or bladder wall during chronic implants of two months duration. The tissue remained excitable during this time when stimulated at rates between 10 and 40 pulses per second at pulse amplitudes below 50 volts. Intravesical pressure rises in excess of centimeters H O were typically obtained and complete bladder evacuation was induced.

The electrode is so designed that it will follow contour variations in an organ stimulated by it without interfering with the organs normal contractile function. Thus, by embedding the electrode in the wall of an organ, only neural and contractile cells located within this wall will be excited when electrical stimuli are applied between the two wires in the electrode so that contraction of only the stimulated organ will be accomplished. The electrode can be surgically embedded by incision of the outer layers of the organ to be stimulated, placing the electrode entirely in the wound produced by the incision and suturing over it.

1 Alternatively, as shown in FIGS. 3 and 4, the electrode 10 may be positioned on the surface 21 of the organ by means of sutures 22. The sutures 22 are passed into and out of the tissue 23 of the organ on one side of the electrode, passed over the electrode and then into and out of the tissue on the opposite side, as

' shown in FIG. 3. Then, as shown in FIG. 4, the elecstrands such as braided nylon suture, silk, polyester, or the like. Conductors 11A and 12A are wrapped helically in parallel spaced relation, with the spacing between conductors approximately equaling the diameter of the electrode, as already described. In order to maintain the conductors spaced from one another, a pair of insulator spacer strands 25 and 26 are wrapped in the same helical fashion spaced between the adjacent winds of the conductors. These insulative strands 25 and 26 are shown as being stippled, for greater clarity.

The conductor wires 11A and 11B and alternating spacers 25 and 26 are maintained in the described relationship by means of four insulative strands 27-30 helically wound in the opposite direction from the conductor and spacer strands with substantially the same spacing and interwoven with the conductors and spacers. Thus it will be seen that one supporting strand is interwoven so as to pass under each conductor wire and over each spacer strand. The next adjacent supporting strand is interwoven to pass over each conductor wire and under each spacer strand and so on for the length of the electrode. The result is a symmetrical tubular configuration in which the helical spatial relationship of the conductor wires is maintained and separation of the wires is assured. A flexible insulative core may be within the electrode or not, as desired. For convenience the woven electrode is shown as formed on an elongated cylindrical core or mandrel which may be removed before the electrode is put into use. Conductors are provided with insulated lead-ins for connection to a source of electrical stimuli. This form of electrode may be imbricated in the manner already described.

It is apparent that many modifications and variations of this invention as hereinbefore set forth may be made without departing from the spirit and scope thereof. The specific embodiments described are given by way of example only and the invention is limited only by the terms of the appended claims.

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:

1. An electrical stimulation electrode for implantation in a living body, said electrode consisting essentially of:

A. a pair of elongated parallel spaced apart helically wound electrical conductors, said conductors being conductive filaments,

B. means for supporting and maintaining said conductors in parallel spaced apart helically wound configuration, said means comprising:

1. a pair of elongated parallel spaced apart helically wound insulative spacer strands, said spacer strands being alternated with said conductors and wound in the same direction, and

2. two pairs of elongated parallel spaced apart helically wound insulative supporting strands, said supporting strands being wound in the opposite direction from said conductors and spacer strands and interwoven therewith, and

C. insulated conductor means for connecting said helically wound conductors to a source of electrical stimuli.

2. An electrical stimulation electrode according to claim 1 further characterized in that said conductors are spaced apart a distance about equal to the diameter of the helical configuration.

3. An electrical stimulation electrode according to claim 2 further characterized in that the spacing between said conductors and the diameter of said helaical configuration are between about 1 and 3 mm.

4. An electrical stimulation electrode according to claim 1 further characterized in that said insulative strands are formed from nylon.

5. An electrical stimulation electrode according to claim 1 further characterized in that said insulative strands are formed from silk.

6. An electrical stimulation electrode according to claim 1 further characterized in that said insulative strands are formed from polyester.

7. An electrical stimulation electrode according to claim 1 further characterized in that said conductors are formed from stainless steel wire.

8. An electrical stimulation electrode according to claim 1 further characterized in that said conductors are formed from platinum wire.

9. An electrical stimulation electrode according to claim 1 further characterized in that said conductors are formed from platinum alloy wire.

10. An electrical stimulation electrode according to claim 1 further characterized in that said conductors are formed from carbon impregnated polyester filament.

Claims (11)

1. An electrical stimulation electrode for implantation in a living body, said electrode consisting essentially of: A. a pair of elongated parallel spaced apart helically wound electrical conductors, said conductors being conductive filaments, B. means for supporting and maintaining said conductors in parallel spaced apart helically wound configuration, said means comprising: 1. a pair of elongated parallel spaced apart helically wound insulative spacer strands, said spacer strands being alternated with said conductors and wound in the same direction, and 2. two pairs of elongated parallel spaced apart helically wound insulative supporting strands, said supporting strands being wound in the opposite direction from said conductors and spacer strands and interwoven therewith, and C. insulated conductor means for connecting said helically wound conductors to a source of electrical stimuli.
2. two pairs of elongated parallel spaced apart helically wound insulative supporting strands, said supporting strands being wound in the opposite direction from said conductors and spacer strands and interwoven therewith, and C. insulated conductor means for connecting said helically wound conductors to a source of electrical stimuli.
2. An electrical stimulation electrode according to claim 1 further characterized in that said conductors are spaced apart a distance about equal to the diameter of the helical configuration.
3. An electrical stimulation electrode according to claim 2 further characterized in that the spacing between said conductors and the diameter of said helaical configuration are between about 1 and 3 mm.
4. An electrical stimulation electrode according to claim 1 further characterized in that said insulative strands are formed from nylon.
5. An electrical stimulation electrode according to claim 1 further characterized in that said insulative strands are formed from silk.
6. An electrical stimulation electrode according to claim 1 further characterized in that said insulative strands are formed from polyester.
7. An electrical stimulation electrode according to claim 1 further characterized in that said conductors are formed from stainless steel wire.
8. An electrical stimulation electrode according to claim 1 further characterized in that said conductors are formed from platinum wire.
9. An electrical stimulation electrode according to claim 1 further characterized in that said conductors are formed from platinum alloy wire.
10. An electrical stimulation electrode according to claim 1 further characterized in that said conductors are formed from carbon impregnated polyester filament.
US3760812A 1971-03-19 1971-03-19 Implantable spiral wound stimulation electrodes Expired - Lifetime US3760812A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12614571 true 1971-03-19 1971-03-19

Publications (1)

Publication Number Publication Date
US3760812A true US3760812A (en) 1973-09-25

Family

ID=22423216

Family Applications (1)

Application Number Title Priority Date Filing Date
US3760812A Expired - Lifetime US3760812A (en) 1971-03-19 1971-03-19 Implantable spiral wound stimulation electrodes

Country Status (1)

Country Link
US (1) US3760812A (en)

Cited By (131)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3935864A (en) * 1973-07-04 1976-02-03 Hans Lagergren Endocardial electrode
US4131757A (en) * 1977-08-10 1978-12-26 United States Steel Corporation Helically wound retaining member for a double caged armored electromechanical cable
DE3043189A1 (en) * 1980-11-15 1982-06-03 Osypka Peter Compact heart pacemaker electrode - has coaxial windings for separate electrode pole conductors
DE3046667A1 (en) * 1980-12-11 1982-07-22 Osypka Peter Bipolar or multipolar electrode for cardiac stimulator - has electrode conductors are wound to form multiple helix with same exterior dia.
WO1983004182A1 (en) * 1982-05-27 1983-12-08 Berkley And Company, Inc. Hollow conductive medical tubing
US4573481A (en) * 1984-06-25 1986-03-04 Huntington Institute Of Applied Research Implantable electrode array
US4590946A (en) * 1984-06-14 1986-05-27 Biomed Concepts, Inc. Surgically implantable electrode for nerve bundles
US4640983A (en) * 1984-04-09 1987-02-03 Institut Straumann Ag Conductor device, particularly for at least partial insertion in a human or animal body, comprising a spiral formed from at least one conductor
US4706682A (en) * 1985-08-21 1987-11-17 Minnesota Mining And Manufacturing Company External ear canal electrode to be placed proximate the tympanic membrane
EP0369044A1 (en) * 1988-11-14 1990-05-23 Siemens Elema AB Electrode arrangement
US4945342A (en) * 1987-10-16 1990-07-31 Instit Straumann Electrical cable for performing stimulations and/or measurements inside a human or animal body and method of manufacturing the cable
US4986372A (en) * 1989-09-12 1991-01-22 Hubbell Incorporated Electrical cable with spirally wrapped wires
US5016646A (en) * 1988-11-29 1991-05-21 Telectronics, N.V. Thin electrode lead and connections
US5016808A (en) * 1989-09-14 1991-05-21 Cardiac Pacemakers, Inc. Implantable tapered spiral endocardial lead for use in internal defibrillation
US5203348A (en) * 1990-06-06 1993-04-20 Cardiac Pacemakers, Inc. Subcutaneous defibrillation electrodes
US5230337A (en) * 1990-06-06 1993-07-27 Cardiac Pacemakers, Inc. Process for implanting subcutaneous defibrillation electrodes
US5257634A (en) * 1992-07-16 1993-11-02 Angeion Corporation Low impedence defibrillation catheter electrode
US5366493A (en) * 1991-02-04 1994-11-22 Case Western Reserve University Double helix functional stimulation electrode
US5366496A (en) * 1993-04-01 1994-11-22 Cardiac Pacemakers, Inc. Subcutaneous shunted coil electrode
US5409467A (en) * 1992-10-02 1995-04-25 Board Of Regents, The University Of Texas System Antimicrobial catheter
US5549109A (en) * 1993-10-01 1996-08-27 Target Therapeutics, Inc. Sheathed multipolar catheter and multipolar guidewire for sensing cardiac electrical activity
WO1998053878A1 (en) * 1997-05-28 1998-12-03 Transneuronix, Inc. Implant device for electrostimulation and/or monitoring of endo-abdominal cavity tissue
US6112122A (en) * 1998-11-17 2000-08-29 Electro-Biology, Inc. Preformed extendable mesh cathode for implantable bone growth stimulator
US6146391A (en) * 1998-07-31 2000-11-14 Transneuronix, Inc. Laparoscopic forceps
US6205359B1 (en) 1998-10-26 2001-03-20 Birinder Bob Boveja Apparatus and method for adjunct (add-on) therapy of partial complex epilepsy, generalized epilepsy and involuntary movement disorders utilizing an external stimulator
US6208902B1 (en) 1998-10-26 2001-03-27 Birinder Bob Boveja Apparatus and method for adjunct (add-on) therapy for pain syndromes utilizing an implantable lead and an external stimulator
US6269270B1 (en) 1998-10-26 2001-07-31 Birinder Bob Boveja Apparatus and method for adjunct (add-on) therapy of Dementia and Alzheimer's disease utilizing an implantable lead and external stimulator
US6321124B1 (en) 1997-05-28 2001-11-20 Transneuronix, Inc. Implant device for electrostimulation and/or monitoring of endo-abdominal cavity tissue
US6381495B1 (en) 1997-05-28 2002-04-30 Transneuronix, Inc. Medical device for use in laparoscopic surgery
US20020143377A1 (en) * 2001-03-30 2002-10-03 Micronet Medical, Inc. Lead body and method of lead body construction
US6477423B1 (en) 1997-05-28 2002-11-05 Transneuronix, Inc. Medical device for use in laparoscopic surgery
US6501991B1 (en) * 2000-06-21 2002-12-31 Medtronic, Inc. Electrically-isolated multiple conductor lead body
US6510332B1 (en) 1999-08-30 2003-01-21 Transneuronix, Inc. Electrode leads for use in laparoscopic surgery
US6564102B1 (en) 1998-10-26 2003-05-13 Birinder R. Boveja Apparatus and method for adjunct (add-on) treatment of coma and traumatic brain injury with neuromodulation using an external stimulator
US6606518B1 (en) 1999-08-06 2003-08-12 Transneuronix, Inc. Apparatus and process for stimulation of a state of complete continence in the neospincter in the preparation of continent neostomies
US6611715B1 (en) 1998-10-26 2003-08-26 Birinder R. Boveja Apparatus and method for neuromodulation therapy for obesity and compulsive eating disorders using an implantable lead-receiver and an external stimulator
US6615084B1 (en) 2000-11-15 2003-09-02 Transneuronix, Inc. Process for electrostimulation treatment of morbid obesity
US6615081B1 (en) 1998-10-26 2003-09-02 Birinder R. Boveja Apparatus and method for adjunct (add-on) treatment of diabetes by neuromodulation with an external stimulator
US6668191B1 (en) 1998-10-26 2003-12-23 Birinder R. Boveja Apparatus and method for electrical stimulation adjunct (add-on) therapy of atrial fibrillation, inappropriate sinus tachycardia, and refractory hypertension with an external stimulator
US20040111139A1 (en) * 2002-12-10 2004-06-10 Mccreery Douglas B. Apparatus and methods for differential stimulation of nerve fibers
US20040147977A1 (en) * 2002-03-06 2004-07-29 Loma Linda University Wound healing with feedback control
US20040162595A1 (en) * 2000-09-26 2004-08-19 Transneuronix, Inc. Method and apparatus for intentional impairment of gastric motility and/or efficiency by triggered electrical stimulation of the gastrointestinal tract with respect to the intrinsic gastric electrical activity
US20040172095A1 (en) * 2001-12-21 2004-09-02 David Jenkins Medical implant device for electrostimulation using discrete micro-electrodes
US20050027340A1 (en) * 2003-07-29 2005-02-03 Micronet Medical, Inc. System and method for providing a medical lead body having dual conductor layers
US20050027341A1 (en) * 2003-07-29 2005-02-03 Micronet Medical, Inc. System and method for providing a medical lead body having conductors that are wound in opposite directions
US6879859B1 (en) 1998-10-26 2005-04-12 Birinder R. Boveja External pulse generator for adjunct (add-on) treatment of obesity, eating disorders, neurological, neuropsychiatric, and urological disorders
US20050131467A1 (en) * 2003-11-02 2005-06-16 Boveja Birinder R. Method and apparatus for electrical stimulation therapy for at least one of atrial fibrillation, congestive heart failure, inappropriate sinus tachycardia, and refractory hypertension
US20050138792A1 (en) * 1999-04-26 2005-06-30 Black Damon R. Method of forming a lead
US20050222638A1 (en) * 2004-03-30 2005-10-06 Steve Foley Sensor based gastrointestinal electrical stimulation for the treatment of obesity or motility disorders
US20050222637A1 (en) * 2004-03-30 2005-10-06 Transneuronix, Inc. Tachygastrial electrical stimulation
US20060004353A1 (en) * 2004-06-30 2006-01-05 Ilya Koyfman Flexible electrode device and surgical apparatus equipped with same
US20060111768A1 (en) * 2000-09-26 2006-05-25 Micronet Medical, Inc. Lead body and method of lead body construction
US7096070B1 (en) 2000-02-09 2006-08-22 Transneuronix, Inc. Medical implant device for electrostimulation using discrete micro-electrodes
US20060206160A1 (en) * 2000-11-15 2006-09-14 Transneuronix, Inc. Process and electrostimulation device for treating obesity and/or gastroesophageal reflux disease
US20060247718A1 (en) * 2005-04-28 2006-11-02 Medtronic, Inc. Dual mode electrical stimulation to treat obesity
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US20070027486A1 (en) * 2005-07-29 2007-02-01 Cyberonics, Inc. Medical devices for enhancing intrinsic neural activity
US20070092591A1 (en) * 2005-10-24 2007-04-26 Cyberonics, Inc. Vacuum mandrel for use in fabricating an implantable electrode
US20070100406A1 (en) * 2005-10-28 2007-05-03 Cyberonics, Inc. Insert for implantable electrode
US20070173910A1 (en) * 2006-01-24 2007-07-26 Cyberonics, Inc. Input response override for an implantable medical device
US20070173890A1 (en) * 2006-01-24 2007-07-26 Cyberonics, Inc. Stimulation mode adjustment for an implantable medical device
US20070179580A1 (en) * 2006-01-27 2007-08-02 Cyberonics, Inc. Multipolar stimulation electrode
US20070255374A1 (en) * 2006-04-28 2007-11-01 Cyberonics, Inc. Compensation reduction in tissue stimulation therapy
US20070282387A1 (en) * 2006-05-17 2007-12-06 Medtronic, Inc. Electrical stimulation therapy to promote gastric distention for obesity management
US20080071261A1 (en) * 2006-09-20 2008-03-20 Sherwood Services Ag Electrosurgical radio frequency energy transmission medium
US20080103532A1 (en) * 2006-10-27 2008-05-01 Cyberonics, Inc. Implantable neurostimulator with refractory stimulation
US20080147155A1 (en) * 2006-12-19 2008-06-19 Quan Emerteq Corp. Braided Electrical Lead
US20080183238A1 (en) * 2002-07-26 2008-07-31 Medtronic, Inc. Process for electrostimulation treatment of morbid obesity
US20080269833A1 (en) * 2007-04-26 2008-10-30 Cyberonics, Inc. Trans-esophageal vagus nerve stimulation
US20080269840A1 (en) * 2007-04-26 2008-10-30 Cyberonics, Inc. Non-surgical device and methods for trans-esophageal vagus nerve stimulation
US20080269834A1 (en) * 2007-04-26 2008-10-30 Cyberonics Inc. Non-Surgical Device and Methods for Trans-Esophageal Vagus Nerve Stimulation
US7454245B2 (en) 2005-01-28 2008-11-18 Cyberonics, Inc. Trained and adaptive response in a neurostimulator
US20090030493A1 (en) * 2007-07-27 2009-01-29 Colborn John C Ribbon Electrode
US20090112292A1 (en) * 2007-10-26 2009-04-30 Cyberonics Inc. Dynamic lead condition detection for an implantable medical device
US20090125079A1 (en) * 2007-10-26 2009-05-14 Cyberonics Inc. Alternative operation mode for an implantable medical device based upon lead condition
US7561918B2 (en) 2005-01-28 2009-07-14 Cyberonics, Inc. Autocapture in a neurostimulator
US20090192567A1 (en) * 2008-01-25 2009-07-30 Armstrong Randolph K Method, Apparatus and System for Bipolar Charge Utilization During Stimulation by an Implantable Medical Device
US20090270943A1 (en) * 2008-04-25 2009-10-29 Maschino Steven E Blocking Exogenous Action Potentials by an Implantable Medical Device
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US7620451B2 (en) 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US20100228313A1 (en) * 2009-03-03 2010-09-09 Medtronic, Inc. Electrical stimulation therapy to promote gastric distention for obesity management
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US7869885B2 (en) 2006-04-28 2011-01-11 Cyberonics, Inc Threshold optimization for tissue stimulation therapy
US20110071589A1 (en) * 2009-09-21 2011-03-24 Medtronic, Inc. Waveforms for electrical stimulation therapy
US7937143B2 (en) 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
US20110143648A1 (en) * 2005-01-06 2011-06-16 Oy Halton Group Ltd. Automatic displacement ventilation system with heating mode
US7974707B2 (en) 2007-01-26 2011-07-05 Cyberonics, Inc. Electrode assembly with fibers for a medical device
US7974701B2 (en) 2007-04-27 2011-07-05 Cyberonics, Inc. Dosing limitation for an implantable medical device
US8131371B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US8145317B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US8150520B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods for catheter-based renal denervation
US8150508B2 (en) 2006-03-29 2012-04-03 Catholic Healthcare West Vagus nerve stimulation method
US8180462B2 (en) 2006-04-18 2012-05-15 Cyberonics, Inc. Heat dissipation for a lead assembly
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
WO2013016203A1 (en) * 2011-07-22 2013-01-31 Boston Scientific Scimed, Inc. Nerve modulation system with a nerve modulation element positionable in a helical guide
US8428731B2 (en) 2005-10-27 2013-04-23 Cyberonics, Inc. Sequenced therapy protocols for an implantable medical device
US8457747B2 (en) 2008-10-20 2013-06-04 Cyberonics, Inc. Neurostimulation with signal duration determined by a cardiac cycle
US8478428B2 (en) 2010-04-23 2013-07-02 Cyberonics, Inc. Helical electrode for nerve stimulation
US8478420B2 (en) 2006-07-12 2013-07-02 Cyberonics, Inc. Implantable medical device charge balance assessment
US8483846B2 (en) 2006-07-26 2013-07-09 Cyberonics, Inc. Multi-electrode assembly for an implantable medical device
US20130192129A1 (en) * 2012-01-27 2013-08-01 Lifewave, Inc. Agricultural Applications of a Double Helix Conductor
US8565867B2 (en) 2005-01-28 2013-10-22 Cyberonics, Inc. Changeable electrode polarity stimulation by an implantable medical device
US8600521B2 (en) 2005-01-27 2013-12-03 Cyberonics, Inc. Implantable medical device having multiple electrode/sensor capability and stimulation based on sensed intrinsic activity
US8620423B2 (en) 2002-04-08 2013-12-31 Medtronic Ardian Luxembourg S.A.R.L. Methods for thermal modulation of nerves contributing to renal function
US8626300B2 (en) 2002-04-08 2014-01-07 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for thermally-induced renal neuromodulation
US8694118B2 (en) 2005-10-28 2014-04-08 Cyberonics, Inc. Variable output ramping for an implantable medical device
US8749333B2 (en) 2012-04-26 2014-06-10 Lifewave, Inc. System configuration using a double helix conductor
US8771252B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and devices for renal nerve blocking
US8774922B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US8818514B2 (en) 2002-04-08 2014-08-26 Medtronic Ardian Luxembourg S.A.R.L. Methods for intravascularly-induced neuromodulation
US8961384B2 (en) 2012-02-13 2015-02-24 Medical Energetics Ltd Health applications of a double helix conductor
US9030283B2 (en) 2011-03-03 2015-05-12 Medical Energetics Ltd Double helix conductor
US9192715B2 (en) 2002-04-08 2015-11-24 Medtronic Ardian Luxembourg S.A.R.L. Methods for renal nerve blocking
US9308044B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US9308043B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US9314633B2 (en) 2008-01-25 2016-04-19 Cyberonics, Inc. Contingent cardio-protection for epilepsy patients
US9327122B2 (en) 2002-04-08 2016-05-03 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US9370667B2 (en) 2014-04-07 2016-06-21 Medical Energetics Ltd Double helix conductor for medical applications using stem cell technology
US9439726B2 (en) 2002-04-08 2016-09-13 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US9463331B2 (en) 2014-04-07 2016-10-11 Medical Energetics Ltd Using a double helix conductor to treat neuropathic disorders
US9504844B2 (en) 2013-06-12 2016-11-29 Medical Energetics Ltd Health applications for using bio-feedback to control an electromagnetic field
US9636518B2 (en) 2013-10-28 2017-05-02 Medical Energetics Ltd. Nested double helix conductors
US9649146B2 (en) 2012-10-02 2017-05-16 Covidien Lp Electro-thermal device
US9717926B2 (en) 2014-03-05 2017-08-01 Medical Energetics Ltd. Double helix conductor with eight connectors and counter-rotating fields
US9724531B2 (en) 2013-10-28 2017-08-08 Medical Energetics Ltd. Double helix conductor with light emitting fluids for producing photobiomodulation effects in living organisms
US9827436B2 (en) 2015-03-02 2017-11-28 Medical Energetics Ltd. Systems and methods to improve the growth rate of livestock, fish, and other animals
US9861830B1 (en) 2013-12-13 2018-01-09 Medical Energetics Ltd. Double helix conductor with winding around core

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3035583A (en) * 1959-05-27 1962-05-22 Hirsch Winfred Conductive sutures
US3453374A (en) * 1968-05-03 1969-07-01 Us Navy Resilient electrical cable
US3474791A (en) * 1966-03-24 1969-10-28 Brunswick Corp Multiple conductor electrode
US3572344A (en) * 1968-12-31 1971-03-23 Medtronic Inc Electrode apparatus with lead construction

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3035583A (en) * 1959-05-27 1962-05-22 Hirsch Winfred Conductive sutures
US3474791A (en) * 1966-03-24 1969-10-28 Brunswick Corp Multiple conductor electrode
US3453374A (en) * 1968-05-03 1969-07-01 Us Navy Resilient electrical cable
US3572344A (en) * 1968-12-31 1971-03-23 Medtronic Inc Electrode apparatus with lead construction

Cited By (247)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3935864A (en) * 1973-07-04 1976-02-03 Hans Lagergren Endocardial electrode
US4131757A (en) * 1977-08-10 1978-12-26 United States Steel Corporation Helically wound retaining member for a double caged armored electromechanical cable
DE3043189A1 (en) * 1980-11-15 1982-06-03 Osypka Peter Compact heart pacemaker electrode - has coaxial windings for separate electrode pole conductors
DE3046667A1 (en) * 1980-12-11 1982-07-22 Osypka Peter Bipolar or multipolar electrode for cardiac stimulator - has electrode conductors are wound to form multiple helix with same exterior dia.
WO1983004182A1 (en) * 1982-05-27 1983-12-08 Berkley And Company, Inc. Hollow conductive medical tubing
US4484586A (en) * 1982-05-27 1984-11-27 Berkley & Company, Inc. Hollow conductive medical tubing
US4640983A (en) * 1984-04-09 1987-02-03 Institut Straumann Ag Conductor device, particularly for at least partial insertion in a human or animal body, comprising a spiral formed from at least one conductor
US4590946A (en) * 1984-06-14 1986-05-27 Biomed Concepts, Inc. Surgically implantable electrode for nerve bundles
US4573481A (en) * 1984-06-25 1986-03-04 Huntington Institute Of Applied Research Implantable electrode array
US4706682A (en) * 1985-08-21 1987-11-17 Minnesota Mining And Manufacturing Company External ear canal electrode to be placed proximate the tympanic membrane
US4945342A (en) * 1987-10-16 1990-07-31 Instit Straumann Electrical cable for performing stimulations and/or measurements inside a human or animal body and method of manufacturing the cable
EP0369044A1 (en) * 1988-11-14 1990-05-23 Siemens Elema AB Electrode arrangement
US5016646A (en) * 1988-11-29 1991-05-21 Telectronics, N.V. Thin electrode lead and connections
US4986372A (en) * 1989-09-12 1991-01-22 Hubbell Incorporated Electrical cable with spirally wrapped wires
US5016808A (en) * 1989-09-14 1991-05-21 Cardiac Pacemakers, Inc. Implantable tapered spiral endocardial lead for use in internal defibrillation
US5203348A (en) * 1990-06-06 1993-04-20 Cardiac Pacemakers, Inc. Subcutaneous defibrillation electrodes
US5230337A (en) * 1990-06-06 1993-07-27 Cardiac Pacemakers, Inc. Process for implanting subcutaneous defibrillation electrodes
US5342407A (en) * 1990-06-06 1994-08-30 Cardiac Pacemakers, Inc. Body implantable defibrillation system
US5603732A (en) * 1990-06-06 1997-02-18 Cardiac Pacemakers, Inc. Subcutaneous defibrillation electrodes
US5366493A (en) * 1991-02-04 1994-11-22 Case Western Reserve University Double helix functional stimulation electrode
US5257634A (en) * 1992-07-16 1993-11-02 Angeion Corporation Low impedence defibrillation catheter electrode
US5409467A (en) * 1992-10-02 1995-04-25 Board Of Regents, The University Of Texas System Antimicrobial catheter
US5366496A (en) * 1993-04-01 1994-11-22 Cardiac Pacemakers, Inc. Subcutaneous shunted coil electrode
US5549109A (en) * 1993-10-01 1996-08-27 Target Therapeutics, Inc. Sheathed multipolar catheter and multipolar guidewire for sensing cardiac electrical activity
WO1995017923A1 (en) * 1993-12-28 1995-07-06 Board Of Regents, The University Of Texas System Antimicrobial medical devices
WO1998053878A1 (en) * 1997-05-28 1998-12-03 Transneuronix, Inc. Implant device for electrostimulation and/or monitoring of endo-abdominal cavity tissue
US6041258A (en) * 1997-05-28 2000-03-21 Transneuronix, Inc. Medical stimulation
US6381495B1 (en) 1997-05-28 2002-04-30 Transneuronix, Inc. Medical device for use in laparoscopic surgery
US6321124B1 (en) 1997-05-28 2001-11-20 Transneuronix, Inc. Implant device for electrostimulation and/or monitoring of endo-abdominal cavity tissue
US6477423B1 (en) 1997-05-28 2002-11-05 Transneuronix, Inc. Medical device for use in laparoscopic surgery
US6146391A (en) * 1998-07-31 2000-11-14 Transneuronix, Inc. Laparoscopic forceps
US6611715B1 (en) 1998-10-26 2003-08-26 Birinder R. Boveja Apparatus and method for neuromodulation therapy for obesity and compulsive eating disorders using an implantable lead-receiver and an external stimulator
US6205359B1 (en) 1998-10-26 2001-03-20 Birinder Bob Boveja Apparatus and method for adjunct (add-on) therapy of partial complex epilepsy, generalized epilepsy and involuntary movement disorders utilizing an external stimulator
US6208902B1 (en) 1998-10-26 2001-03-27 Birinder Bob Boveja Apparatus and method for adjunct (add-on) therapy for pain syndromes utilizing an implantable lead and an external stimulator
US6668191B1 (en) 1998-10-26 2003-12-23 Birinder R. Boveja Apparatus and method for electrical stimulation adjunct (add-on) therapy of atrial fibrillation, inappropriate sinus tachycardia, and refractory hypertension with an external stimulator
US6879859B1 (en) 1998-10-26 2005-04-12 Birinder R. Boveja External pulse generator for adjunct (add-on) treatment of obesity, eating disorders, neurological, neuropsychiatric, and urological disorders
US6615081B1 (en) 1998-10-26 2003-09-02 Birinder R. Boveja Apparatus and method for adjunct (add-on) treatment of diabetes by neuromodulation with an external stimulator
US6615085B1 (en) 1998-10-26 2003-09-02 Birinder R. Boveja Apparatus for adjunct (add-on) therapy of Dementia and Alzheimer's disease utilizing an implantable lead and an external stimulator
US6564102B1 (en) 1998-10-26 2003-05-13 Birinder R. Boveja Apparatus and method for adjunct (add-on) treatment of coma and traumatic brain injury with neuromodulation using an external stimulator
US6269270B1 (en) 1998-10-26 2001-07-31 Birinder Bob Boveja Apparatus and method for adjunct (add-on) therapy of Dementia and Alzheimer's disease utilizing an implantable lead and external stimulator
US6112122A (en) * 1998-11-17 2000-08-29 Electro-Biology, Inc. Preformed extendable mesh cathode for implantable bone growth stimulator
US20100077606A1 (en) * 1999-04-26 2010-04-01 Damon Ray Black Method of forming a lead
US8671566B2 (en) 1999-04-26 2014-03-18 Advanced Neuromodulation Systems, Inc. Method of forming a lead
US20050138792A1 (en) * 1999-04-26 2005-06-30 Black Damon R. Method of forming a lead
US8316537B2 (en) 1999-04-26 2012-11-27 Advanced Neuromodulation Systems, Inc. Method of forming a lead
US6606518B1 (en) 1999-08-06 2003-08-12 Transneuronix, Inc. Apparatus and process for stimulation of a state of complete continence in the neospincter in the preparation of continent neostomies
US6510332B1 (en) 1999-08-30 2003-01-21 Transneuronix, Inc. Electrode leads for use in laparoscopic surgery
US7096070B1 (en) 2000-02-09 2006-08-22 Transneuronix, Inc. Medical implant device for electrostimulation using discrete micro-electrodes
US6501991B1 (en) * 2000-06-21 2002-12-31 Medtronic, Inc. Electrically-isolated multiple conductor lead body
US7941221B2 (en) 2000-09-26 2011-05-10 Medtronic, Inc. Method and apparatus for intentional impairment of gastric motility and/or efficiency by triggered electrical stimulation of the gastrointestinal tract with respect to the intrinsic gastric electrical activity
US20040162595A1 (en) * 2000-09-26 2004-08-19 Transneuronix, Inc. Method and apparatus for intentional impairment of gastric motility and/or efficiency by triggered electrical stimulation of the gastrointestinal tract with respect to the intrinsic gastric electrical activity
US20060111768A1 (en) * 2000-09-26 2006-05-25 Micronet Medical, Inc. Lead body and method of lead body construction
US7555349B2 (en) 2000-09-26 2009-06-30 Advanced Neuromodulation Systems, Inc. Lead body and method of lead body construction
US6615084B1 (en) 2000-11-15 2003-09-02 Transneuronix, Inc. Process for electrostimulation treatment of morbid obesity
US20060206160A1 (en) * 2000-11-15 2006-09-14 Transneuronix, Inc. Process and electrostimulation device for treating obesity and/or gastroesophageal reflux disease
US20020143377A1 (en) * 2001-03-30 2002-10-03 Micronet Medical, Inc. Lead body and method of lead body construction
US7149585B2 (en) * 2001-03-30 2006-12-12 Micronet Medical, Inc. Lead body and method of lead body construction
US20040172095A1 (en) * 2001-12-21 2004-09-02 David Jenkins Medical implant device for electrostimulation using discrete micro-electrodes
US7016737B2 (en) 2002-03-06 2006-03-21 Loma Linda University Method and device for wound healing
US20040147977A1 (en) * 2002-03-06 2004-07-29 Loma Linda University Wound healing with feedback control
US7079899B2 (en) 2002-03-06 2006-07-18 Loma Linda University Wound healing with feedback control
US20050119715A1 (en) * 2002-03-06 2005-06-02 Petrofsky Jerrold S. Method and device for wound healing
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US9827040B2 (en) 2002-04-08 2017-11-28 Medtronic Adrian Luxembourg S.a.r.l. Methods and apparatus for intravascularly-induced neuromodulation
US8684998B2 (en) 2002-04-08 2014-04-01 Medtronic Ardian Luxembourg S.A.R.L. Methods for inhibiting renal nerve activity
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US9827041B2 (en) 2002-04-08 2017-11-28 Medtronic Ardian Luxembourg S.A.R.L. Balloon catheter apparatuses for renal denervation
US9814873B2 (en) 2002-04-08 2017-11-14 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for bilateral renal neuromodulation
US9757192B2 (en) 2002-04-08 2017-09-12 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation for treatment of patients
US9757193B2 (en) 2002-04-08 2017-09-12 Medtronic Ardian Luxembourg S.A.R.L. Balloon catheter apparatus for renal neuromodulation
US9743983B2 (en) 2002-04-08 2017-08-29 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation for treatment of patients
US9731132B2 (en) 2002-04-08 2017-08-15 Medtronic Ardian Luxembourg S.A.R.L. Methods for renal neuromodulation
US9707035B2 (en) 2002-04-08 2017-07-18 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US9675413B2 (en) 2002-04-08 2017-06-13 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for renal neuromodulation
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US9486270B2 (en) 2002-04-08 2016-11-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for bilateral renal neuromodulation
US9474563B2 (en) 2002-04-08 2016-10-25 Medtronic Ardian Luxembourg S.A.R.L. Methods for renal neuromodulation
US9468497B2 (en) 2002-04-08 2016-10-18 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US8721637B2 (en) 2002-04-08 2014-05-13 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing renal neuromodulation via catheter apparatuses having inflatable balloons
US9463066B2 (en) 2002-04-08 2016-10-11 Medtronic Ardian Luxembourg S.A.R.L. Methods for renal neuromodulation
US9456869B2 (en) 2002-04-08 2016-10-04 Medtronic Ardian Luxembourg S.A.R.L. Methods for bilateral renal neuromodulation
US9445867B1 (en) 2002-04-08 2016-09-20 Medtronic Ardian Luxembourg S.A.R.L. Methods for renal neuromodulation via catheters having expandable treatment members
US9439726B2 (en) 2002-04-08 2016-09-13 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US8948865B2 (en) 2002-04-08 2015-02-03 Medtronic Ardian Luxembourg S.A.R.L. Methods for treating heart arrhythmia
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US9364280B2 (en) 2002-04-08 2016-06-14 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US9327122B2 (en) 2002-04-08 2016-05-03 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US9326817B2 (en) 2002-04-08 2016-05-03 Medtronic Ardian Luxembourg S.A.R.L. Methods for treating heart arrhythmia
US8444640B2 (en) 2002-04-08 2013-05-21 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US9320561B2 (en) 2002-04-08 2016-04-26 Medtronic Ardian Luxembourg S.A.R.L. Methods for bilateral renal neuromodulation
US9314630B2 (en) 2002-04-08 2016-04-19 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation for treatment of patients
US9308043B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US8626300B2 (en) 2002-04-08 2014-01-07 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for thermally-induced renal neuromodulation
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US7647115B2 (en) 2002-04-08 2010-01-12 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8454594B2 (en) 2002-04-08 2013-06-04 Medtronic Ardian Luxembourg S.A.R.L. Apparatus for performing a non-continuous circumferential treatment of a body lumen
US9308044B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US7717948B2 (en) 2002-04-08 2010-05-18 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US9289255B2 (en) 2002-04-08 2016-03-22 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for renal neuromodulation
US9265558B2 (en) 2002-04-08 2016-02-23 Medtronic Ardian Luxembourg S.A.R.L. Methods for bilateral renal neuromodulation
US9192715B2 (en) 2002-04-08 2015-11-24 Medtronic Ardian Luxembourg S.A.R.L. Methods for renal nerve blocking
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US9186213B2 (en) 2002-04-08 2015-11-17 Medtronic Ardian Luxembourg S.A.R.L. Methods for renal neuromodulation
US9186198B2 (en) 2002-04-08 2015-11-17 Medtronic Ardian Luxembourg S.A.R.L. Ultrasound apparatuses for thermally-induced renal neuromodulation and associated systems and methods
US9138281B2 (en) 2002-04-08 2015-09-22 Medtronic Ardian Luxembourg S.A.R.L. Methods for bilateral renal neuromodulation via catheter apparatuses having expandable baskets
US9131978B2 (en) 2002-04-08 2015-09-15 Medtronic Ardian Luxembourg S.A.R.L. Methods for bilateral renal neuromodulation
US9125661B2 (en) 2002-04-08 2015-09-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for renal neuromodulation
US8728138B2 (en) 2002-04-08 2014-05-20 Medtronic Ardian Luxembourg S.A.R.L. Methods for thermally-induced renal neuromodulation
US9072527B2 (en) 2002-04-08 2015-07-07 Medtronic Ardian Luxembourg S.A.R.L. Apparatuses and methods for renal neuromodulation
US9023037B2 (en) 2002-04-08 2015-05-05 Medtronic Ardian Luxembourg S.A.R.L. Balloon catheter apparatus for renal neuromodulation
US8551069B2 (en) 2002-04-08 2013-10-08 Medtronic Adrian Luxembourg S.a.r.l. Methods and apparatus for treating contrast nephropathy
US8986294B2 (en) 2002-04-08 2015-03-24 Medtronic Ardian Luxembourg S.a.rl. Apparatuses for thermally-induced renal neuromodulation
US8983595B2 (en) 2002-04-08 2015-03-17 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation for treatment of patients with chronic heart failure
US8958871B2 (en) 2002-04-08 2015-02-17 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US8934978B2 (en) 2002-04-08 2015-01-13 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for renal neuromodulation
US8880186B2 (en) 2002-04-08 2014-11-04 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation for treatment of patients with chronic heart failure
US8852163B2 (en) 2002-04-08 2014-10-07 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation via drugs and neuromodulatory agents and associated systems and methods
US8845629B2 (en) 2002-04-08 2014-09-30 Medtronic Ardian Luxembourg S.A.R.L. Ultrasound apparatuses for thermally-induced renal neuromodulation
US8131371B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US8131372B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Renal nerve stimulation method for treatment of patients
US8145317B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8620423B2 (en) 2002-04-08 2013-12-31 Medtronic Ardian Luxembourg S.A.R.L. Methods for thermal modulation of nerves contributing to renal function
US8150520B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods for catheter-based renal denervation
US8150518B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US8818514B2 (en) 2002-04-08 2014-08-26 Medtronic Ardian Luxembourg S.A.R.L. Methods for intravascularly-induced neuromodulation
US8728137B2 (en) 2002-04-08 2014-05-20 Medtronic Ardian Luxembourg S.A.R.L. Methods for thermally-induced renal neuromodulation
US8175711B2 (en) 2002-04-08 2012-05-08 Ardian, Inc. Methods for treating a condition or disease associated with cardio-renal function
US8548600B2 (en) 2002-04-08 2013-10-01 Medtronic Ardian Luxembourg S.A.R.L. Apparatuses for renal neuromodulation and associated systems and methods
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US8774922B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods
US8771252B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and devices for renal nerve blocking
US8768470B2 (en) 2002-04-08 2014-07-01 Medtronic Ardian Luxembourg S.A.R.L. Methods for monitoring renal neuromodulation
US8740896B2 (en) 2002-04-08 2014-06-03 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing renal neuromodulation via catheter apparatuses having inflatable balloons
US8784463B2 (en) 2002-04-08 2014-07-22 Medtronic Ardian Luxembourg S.A.R.L. Methods for thermally-induced renal neuromodulation
US20080183238A1 (en) * 2002-07-26 2008-07-31 Medtronic, Inc. Process for electrostimulation treatment of morbid obesity
US20040111139A1 (en) * 2002-12-10 2004-06-10 Mccreery Douglas B. Apparatus and methods for differential stimulation of nerve fibers
US20050027341A1 (en) * 2003-07-29 2005-02-03 Micronet Medical, Inc. System and method for providing a medical lead body having conductors that are wound in opposite directions
US20050027340A1 (en) * 2003-07-29 2005-02-03 Micronet Medical, Inc. System and method for providing a medical lead body having dual conductor layers
US20050131467A1 (en) * 2003-11-02 2005-06-16 Boveja Birinder R. Method and apparatus for electrical stimulation therapy for at least one of atrial fibrillation, congestive heart failure, inappropriate sinus tachycardia, and refractory hypertension
US20050222638A1 (en) * 2004-03-30 2005-10-06 Steve Foley Sensor based gastrointestinal electrical stimulation for the treatment of obesity or motility disorders
US20050222637A1 (en) * 2004-03-30 2005-10-06 Transneuronix, Inc. Tachygastrial electrical stimulation
US7481808B2 (en) 2004-06-30 2009-01-27 Ethicon, Inc. Flexible electrode device and surgical apparatus equipped with same
US20060004353A1 (en) * 2004-06-30 2006-01-05 Ilya Koyfman Flexible electrode device and surgical apparatus equipped with same
US9108040B2 (en) 2004-10-05 2015-08-18 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for multi-vessel renal neuromodulation
US8433423B2 (en) 2004-10-05 2013-04-30 Ardian, Inc. Methods for multi-vessel renal neuromodulation
US8805545B2 (en) 2004-10-05 2014-08-12 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for multi-vessel renal neuromodulation
US9402992B2 (en) 2004-10-05 2016-08-02 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for multi-vessel renal neuromodulation
US7937143B2 (en) 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
US20110143648A1 (en) * 2005-01-06 2011-06-16 Oy Halton Group Ltd. Automatic displacement ventilation system with heating mode
US8600521B2 (en) 2005-01-27 2013-12-03 Cyberonics, Inc. Implantable medical device having multiple electrode/sensor capability and stimulation based on sensed intrinsic activity
US8565867B2 (en) 2005-01-28 2013-10-22 Cyberonics, Inc. Changeable electrode polarity stimulation by an implantable medical device
US7454245B2 (en) 2005-01-28 2008-11-18 Cyberonics, Inc. Trained and adaptive response in a neurostimulator
US9586047B2 (en) 2005-01-28 2017-03-07 Cyberonics, Inc. Contingent cardio-protection for epilepsy patients
US7561918B2 (en) 2005-01-28 2009-07-14 Cyberonics, Inc. Autocapture in a neurostimulator
US20060247718A1 (en) * 2005-04-28 2006-11-02 Medtronic, Inc. Dual mode electrical stimulation to treat obesity
US20070027486A1 (en) * 2005-07-29 2007-02-01 Cyberonics, Inc. Medical devices for enhancing intrinsic neural activity
US20070092591A1 (en) * 2005-10-24 2007-04-26 Cyberonics, Inc. Vacuum mandrel for use in fabricating an implantable electrode
US7901613B2 (en) 2005-10-24 2011-03-08 Cyberonics, Inc. Vacuum mandrel for use in fabricating an implantable electrode
US20100101944A1 (en) * 2005-10-24 2010-04-29 Cyberonics, Inc. Vacuum mandrel for use in fabricating an implantable electrode
US8428731B2 (en) 2005-10-27 2013-04-23 Cyberonics, Inc. Sequenced therapy protocols for an implantable medical device
US9802048B2 (en) 2005-10-28 2017-10-31 Cyberonics, Inc. Variable output ramping for an implantable medical device
US8509914B2 (en) 2005-10-28 2013-08-13 Cyberonics, Inc. Insert for implantable electrode
US8694118B2 (en) 2005-10-28 2014-04-08 Cyberonics, Inc. Variable output ramping for an implantable medical device
US20070100406A1 (en) * 2005-10-28 2007-05-03 Cyberonics, Inc. Insert for implantable electrode
US7620451B2 (en) 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US7996079B2 (en) 2006-01-24 2011-08-09 Cyberonics, Inc. Input response override for an implantable medical device
US20070173890A1 (en) * 2006-01-24 2007-07-26 Cyberonics, Inc. Stimulation mode adjustment for an implantable medical device
US20070173910A1 (en) * 2006-01-24 2007-07-26 Cyberonics, Inc. Input response override for an implantable medical device
US7467016B2 (en) 2006-01-27 2008-12-16 Cyberonics, Inc. Multipolar stimulation electrode with mating structures for gripping targeted tissue
US20070179580A1 (en) * 2006-01-27 2007-08-02 Cyberonics, Inc. Multipolar stimulation electrode
US9108041B2 (en) 2006-03-29 2015-08-18 Dignity Health Microburst electrical stimulation of cranial nerves for the treatment of medical conditions
US8219188B2 (en) 2006-03-29 2012-07-10 Catholic Healthcare West Synchronization of vagus nerve stimulation with the cardiac cycle of a patient
US8615309B2 (en) 2006-03-29 2013-12-24 Catholic Healthcare West Microburst electrical stimulation of cranial nerves for the treatment of medical conditions
US8660666B2 (en) 2006-03-29 2014-02-25 Catholic Healthcare West Microburst electrical stimulation of cranial nerves for the treatment of medical conditions
US9533151B2 (en) 2006-03-29 2017-01-03 Dignity Health Microburst electrical stimulation of cranial nerves for the treatment of medical conditions
US8150508B2 (en) 2006-03-29 2012-04-03 Catholic Healthcare West Vagus nerve stimulation method
US8280505B2 (en) 2006-03-29 2012-10-02 Catholic Healthcare West Vagus nerve stimulation method
US9289599B2 (en) 2006-03-29 2016-03-22 Dignity Health Vagus nerve stimulation method
US8738126B2 (en) 2006-03-29 2014-05-27 Catholic Healthcare West Synchronization of vagus nerve stimulation with the cardiac cycle of a patient
US8180462B2 (en) 2006-04-18 2012-05-15 Cyberonics, Inc. Heat dissipation for a lead assembly
US20070255374A1 (en) * 2006-04-28 2007-11-01 Cyberonics, Inc. Compensation reduction in tissue stimulation therapy
US7869885B2 (en) 2006-04-28 2011-01-11 Cyberonics, Inc Threshold optimization for tissue stimulation therapy
US7962220B2 (en) 2006-04-28 2011-06-14 Cyberonics, Inc. Compensation reduction in tissue stimulation therapy
US8185206B2 (en) 2006-05-17 2012-05-22 Medtronic, Inc. Electrical stimulation therapy to promote gastric distention for obesity management
US20070282387A1 (en) * 2006-05-17 2007-12-06 Medtronic, Inc. Electrical stimulation therapy to promote gastric distention for obesity management
US8478420B2 (en) 2006-07-12 2013-07-02 Cyberonics, Inc. Implantable medical device charge balance assessment
US8483846B2 (en) 2006-07-26 2013-07-09 Cyberonics, Inc. Multi-electrode assembly for an implantable medical device
US20080071261A1 (en) * 2006-09-20 2008-03-20 Sherwood Services Ag Electrosurgical radio frequency energy transmission medium
US7819865B2 (en) * 2006-09-20 2010-10-26 Covidien Ag Electrosurgical radio frequency energy transmission medium
US9375244B2 (en) * 2006-09-20 2016-06-28 Covidien Ag Electrosurgical radio frequency energy transmission medium
US20110015629A1 (en) * 2006-09-20 2011-01-20 Orszulak James H Electrosurgical Radio Frequency Energy Transmission Medium
US8353904B2 (en) 2006-09-20 2013-01-15 Covidien Ag Electrosurgical radio frequency energy transmission medium
US20130138098A1 (en) * 2006-09-20 2013-05-30 Covidien Ag Electrosurgical radio frequency energy transmission medium
US7985220B2 (en) 2006-09-20 2011-07-26 Coviden Ag Electrosurgical radio frequency energy transmission medium
US20080103532A1 (en) * 2006-10-27 2008-05-01 Cyberonics, Inc. Implantable neurostimulator with refractory stimulation
US7869867B2 (en) 2006-10-27 2011-01-11 Cyberonics, Inc. Implantable neurostimulator with refractory stimulation
US8160719B2 (en) 2006-12-19 2012-04-17 Greatbatch Ltd. Braided electrical lead
US20080147155A1 (en) * 2006-12-19 2008-06-19 Quan Emerteq Corp. Braided Electrical Lead
EP1935449A1 (en) * 2006-12-19 2008-06-25 Quan Emerteq Corporation Braided electrical lead
US7974707B2 (en) 2007-01-26 2011-07-05 Cyberonics, Inc. Electrode assembly with fibers for a medical device
US8295946B2 (en) 2007-01-26 2012-10-23 Cyberonics, Inc. Electrode assembly with fibers for a medical device
US7962214B2 (en) 2007-04-26 2011-06-14 Cyberonics, Inc. Non-surgical device and methods for trans-esophageal vagus nerve stimulation
US20080269840A1 (en) * 2007-04-26 2008-10-30 Cyberonics, Inc. Non-surgical device and methods for trans-esophageal vagus nerve stimulation
US20080269834A1 (en) * 2007-04-26 2008-10-30 Cyberonics Inc. Non-Surgical Device and Methods for Trans-Esophageal Vagus Nerve Stimulation
US7904175B2 (en) 2007-04-26 2011-03-08 Cyberonics, Inc. Trans-esophageal vagus nerve stimulation
US7869884B2 (en) 2007-04-26 2011-01-11 Cyberonics, Inc. Non-surgical device and methods for trans-esophageal vagus nerve stimulation
US20080269833A1 (en) * 2007-04-26 2008-10-30 Cyberonics, Inc. Trans-esophageal vagus nerve stimulation
US7974701B2 (en) 2007-04-27 2011-07-05 Cyberonics, Inc. Dosing limitation for an implantable medical device
US8306627B2 (en) 2007-04-27 2012-11-06 Cyberonics, Inc. Dosing limitation for an implantable medical device
US20090030493A1 (en) * 2007-07-27 2009-01-29 Colborn John C Ribbon Electrode
US7818069B2 (en) 2007-07-27 2010-10-19 Cyberonics, Inc. Ribbon electrode
US8868203B2 (en) 2007-10-26 2014-10-21 Cyberonics, Inc. Dynamic lead condition detection for an implantable medical device
US20090125079A1 (en) * 2007-10-26 2009-05-14 Cyberonics Inc. Alternative operation mode for an implantable medical device based upon lead condition
US8942798B2 (en) 2007-10-26 2015-01-27 Cyberonics, Inc. Alternative operation mode for an implantable medical device based upon lead condition
US20090112292A1 (en) * 2007-10-26 2009-04-30 Cyberonics Inc. Dynamic lead condition detection for an implantable medical device
US9314633B2 (en) 2008-01-25 2016-04-19 Cyberonics, Inc. Contingent cardio-protection for epilepsy patients
US8260426B2 (en) 2008-01-25 2012-09-04 Cyberonics, Inc. Method, apparatus and system for bipolar charge utilization during stimulation by an implantable medical device
US20090192567A1 (en) * 2008-01-25 2009-07-30 Armstrong Randolph K Method, Apparatus and System for Bipolar Charge Utilization During Stimulation by an Implantable Medical Device
US20090270943A1 (en) * 2008-04-25 2009-10-29 Maschino Steven E Blocking Exogenous Action Potentials by an Implantable Medical Device
US8204603B2 (en) 2008-04-25 2012-06-19 Cyberonics, Inc. Blocking exogenous action potentials by an implantable medical device
US8874218B2 (en) 2008-10-20 2014-10-28 Cyberonics, Inc. Neurostimulation with signal duration determined by a cardiac cycle
US8457747B2 (en) 2008-10-20 2013-06-04 Cyberonics, Inc. Neurostimulation with signal duration determined by a cardiac cycle
US20100228313A1 (en) * 2009-03-03 2010-09-09 Medtronic, Inc. Electrical stimulation therapy to promote gastric distention for obesity management
US8538532B2 (en) 2009-03-03 2013-09-17 Medtronic, Inc. Electrical stimulation therapy to promote gastric distention for obesity management
US20110071589A1 (en) * 2009-09-21 2011-03-24 Medtronic, Inc. Waveforms for electrical stimulation therapy
US8478428B2 (en) 2010-04-23 2013-07-02 Cyberonics, Inc. Helical electrode for nerve stimulation
US9030283B2 (en) 2011-03-03 2015-05-12 Medical Energetics Ltd Double helix conductor
WO2013016203A1 (en) * 2011-07-22 2013-01-31 Boston Scientific Scimed, Inc. Nerve modulation system with a nerve modulation element positionable in a helical guide
US20130165920A1 (en) * 2011-07-22 2013-06-27 Boston Scientific Scimed, Inc. Nerve modulation system having helical guide
US9186209B2 (en) * 2011-07-22 2015-11-17 Boston Scientific Scimed, Inc. Nerve modulation system having helical guide
US20130192129A1 (en) * 2012-01-27 2013-08-01 Lifewave, Inc. Agricultural Applications of a Double Helix Conductor
US8919035B2 (en) * 2012-01-27 2014-12-30 Medical Energetics Ltd Agricultural applications of a double helix conductor
US9504845B2 (en) 2012-02-13 2016-11-29 Medical Energetics Ltd. Health applications of a double helix conductor
US8961384B2 (en) 2012-02-13 2015-02-24 Medical Energetics Ltd Health applications of a double helix conductor
US9406421B2 (en) 2012-04-26 2016-08-02 Medical Energetics Ltd System configuration using a double helix conductor
US8749333B2 (en) 2012-04-26 2014-06-10 Lifewave, Inc. System configuration using a double helix conductor
US9649146B2 (en) 2012-10-02 2017-05-16 Covidien Lp Electro-thermal device
US9504844B2 (en) 2013-06-12 2016-11-29 Medical Energetics Ltd Health applications for using bio-feedback to control an electromagnetic field
US9724531B2 (en) 2013-10-28 2017-08-08 Medical Energetics Ltd. Double helix conductor with light emitting fluids for producing photobiomodulation effects in living organisms
US9636518B2 (en) 2013-10-28 2017-05-02 Medical Energetics Ltd. Nested double helix conductors
US9861830B1 (en) 2013-12-13 2018-01-09 Medical Energetics Ltd. Double helix conductor with winding around core
US9717926B2 (en) 2014-03-05 2017-08-01 Medical Energetics Ltd. Double helix conductor with eight connectors and counter-rotating fields
US9370667B2 (en) 2014-04-07 2016-06-21 Medical Energetics Ltd Double helix conductor for medical applications using stem cell technology
US9463331B2 (en) 2014-04-07 2016-10-11 Medical Energetics Ltd Using a double helix conductor to treat neuropathic disorders
US9827436B2 (en) 2015-03-02 2017-11-28 Medical Energetics Ltd. Systems and methods to improve the growth rate of livestock, fish, and other animals

Similar Documents

Publication Publication Date Title
US3646940A (en) Implantable electronic stimulator electrode and method
US3474791A (en) Multiple conductor electrode
US3348548A (en) Implantable electrode with stiffening stylet
US3416534A (en) Body organ electrode
US6456888B1 (en) Geometry for coupling and electrode to a conductor
US4402330A (en) Body implantable lead
US4860769A (en) Implantable defibrillation electrode
US5702437A (en) Implantable lead with wires carried by body
US3724467A (en) Electrode implant for the neuro-stimulation of the spinal cord
US5133365A (en) Implantable tapered spiral endocardial lead for use in internal defibrillation
US5105826A (en) Implantable defibrillation electrode and method of manufacture
US6185463B1 (en) Implantable short resistant lead
US7324852B2 (en) System and method for neurological stimulation of peripheral nerves to treat low back pain
US5265623A (en) Optimized field defibrillation catheter
US4938231A (en) Defibrillator electrode
US6370434B1 (en) Cardiac lead and method for lead implantation
US5009229A (en) Steroid eluting intramuscular lead
US7174219B2 (en) Lead electrode for use in an MRI-safe implantable medical device
US4735205A (en) Method and apparatus including a sliding insulation lead for cardiac assistance
US5400784A (en) Slowly penetrating inter-fascicular nerve cuff electrode and method of using
US5417719A (en) Method of using a spinal cord stimulation lead
US20020147486A1 (en) System and method for promoting selective tissue in-growth for an implantable medical device
US20080195186A1 (en) Continuous conductive materials for electromagnetic shielding
US5314459A (en) Defibrillation electrode system having smooth current distribution with floating electrode
US5366496A (en) Subcutaneous shunted coil electrode