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Combination blood sampling vacuum syringe centrifuge container and specimen cup

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US3706306A
US3706306A US3706306DA US3706306A US 3706306 A US3706306 A US 3706306A US 3706306D A US3706306D A US 3706306DA US 3706306 A US3706306 A US 3706306A
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blood
specimen
end
cup
serum
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Harold J Berger
Jerry G Goldsmith
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HAROLD J BERGER
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HAROLD J BERGER
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150015Source of blood
    • A61B5/15003Source of blood for venous or arterial blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150213Venting means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150236Pistons, i.e. cylindrical bodies that sit inside the syringe barrel, typically with an air tight seal, and slide in the barrel to create a vacuum or to expel blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150244Rods for actuating or driving the piston, i.e. the cylindrical body that sits inside the syringe barrel, typically with an air tight seal, and slides in the barrel to create a vacuum or to expel blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150251Collection chamber divided into at least two compartments, e.g. for division of samples
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150267Modular design or construction, i.e. subunits are assembled separately before being joined together or the device comprises interchangeable or detachable modules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150351Caps, stoppers or lids for sealing or closing a blood collection vessel or container, e.g. a test-tube or syringe barrel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381Design of piercing elements
    • A61B5/150389Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381Design of piercing elements
    • A61B5/150473Double-ended needles, e.g. used with pre-evacuated sampling tubes
    • A61B5/150496Details of construction of hub, i.e. element used to attach the double-ended needle to a piercing device or sampling device
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150732Needle holders, for instance for holding the needle by the hub, used for example with double-ended needle and pre-evacuated tube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150755Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/153Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • A61B5/154Devices using pre-evacuated means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150221Valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150259Improved gripping, e.g. with high friction pattern or projections on the housing surface or an ergonometric shape

Abstract

An elongated, unitary, blood sampling vacuum syringe, centrifuge container and specimen cup, for use with an ordinary tubular needle holder is described. The device includes an evacuated blood sample centrifuge container having a piercable diaphragm cap and being supported in spaced relation within one end of a housing member, the opposite end of which housing member is in the form of a separable specimen cup. After obtaining a blood sample in the usual fashion with use of an ordinary tubular needle holder, the device is centrifuged as a unit to separate the blood serum into the upper end of the centrifuge container. Vertically spaced openings provided in an upper side wall portion the centrifuge container and normally sealed off by means of a pressure-sensitive tear strip, are thereafter sequentially opened by manual removal of the tear strip to permit gravitation of the centrifuged blood serum down into the specimen cup, after which said serum-filled specimen cup can be separated for use in analysis.

Description

United States Patent Berger et al.

[ 51 3,706,306 [451 Dec. 19, 1972 [54] COMBINATION BLOOD SAMPLING VACUUM SYRINGE CENTRIFUGE CONTAINER AND SPECIMEN CUP [72] Inventors: Harold J. Berger, Surfside; Jerry G. Goldsmith, Miami Beach, both of Fla.

[22] Filed: March 3, 1971 [21] Appl.No.: 120,475

Mattson 128/2 F Primary Examiner-Kyle L. Howell AttomeyEmest H. Schmidt [5 7] ABSTRACT An elongated, unitary, blood sampling vacuum syringe, centrifuge container and specimen cup, for use with an ordinary tubular needle holder is described. The device includes an evacuated blood sample centrifuge container having a piercable diaphragm cap and being supported in spaced relation within one end of a housing member, the opposite end of which housing member is in the form of a separable specimen cup. After obtaining a blood sample in the usual fashion with use of an ordinary tubular needle holder, the device is centrifuged as a unit to separate the blood serum into the upper end of the centrifuge con- -tainer. Vertically spaced openings provided in an upper side wall portion the centrifuge container and nonnally sealed off by means of a pressure-sensitive tear strip, are thereafter sequentially opened by manual removal of the tear strip to permit gravitation of the centrifuged blood serum down into the specimen cup, after which said serum-filled specimen cup can be separated for use in analysis.

7 Claims, 5 Drawing Figures P'A'TENTEDHEMQ 1912 I 3.706306 INVENTORS. HfiROLD vJ. BERGER BY JERRY 6. 60LD$MITH HTTORNE).

COMBINATION BLOOD SAMPLING VACUUM SYRINGE CENTRIFUGE CONTAINER AND SPECIMEN CUP This invention relates to medical syringes and is directed particularly to improved vacuum syringe devices combining a blood samplecentrifuge container and a serum receiving specimen cup in a unitary structure.

In blood analysis for medical diagnosis or research it is frequently necessary to separate the blood serum from the cellular blood matter for independent chemical analysis. This is usually done by centrifuging a blood sample or specimen taken from the patient or donor with the use of an ordinary pistoncontrolled or vacuum actuated medical syringe. Because freshly drawn blood has a tendency to change in character due to enzymatic action, it is essential that separation and removal of the blood serum be effected as soon as possible after collection to insure valid analysis. It is also important that the procedure undertaken in the centrifuging of the blood sample and removal of the serum specimen be such as to minimize any possibility of contamination. Since, in medical diagnosis, a substantial portion of the blood samples for analysis are taken in private clinics or physicians treatment facilities, and since such facilities vary over a wide range as to laboratory capability, availability and competence of technical personel, the preparation for analysis of blood sample serum is not infrequently of less than op timum quality. It should also be noted that samples obtained in this manner are frequently shipped over long distances before being subjected to chemical analysis. If the cellular blood mass is not properly and totally separated from the serum, a faulty result will be obtained by the receiving laboratory. In such cases the specimen collection agency, and not the receiving laboratory, is at fault. The medical literature as well as the publications in the field of clinical chemistry have, in the past, expressed great concern over these deficiencies and stated that the following determinations are particularly affected. Thus, it is well known that a number of changes ensue when whole blood is allowed to stand without removal of the cellular fraction. The glucose concentration diminishes rapidly, electrolytes migrate across cell membranes to establish new equilibria; phosphatases cleave intracellular organic phosphate esters, increasing the inorganic phosphorous level, and cellular enzymes may leak out causing false serum levels. When hemolysis occurs these effects become exaggerated and, in addition, complications develop with the technical aspects of certain test procedures.

The removal of the centrifuged blood serum from the blood sample for analysis was heretofore accomplished either by manually pouring the serum from the top of the container or tube into the serum specimen cup, or by vacuum withdrawal by mouth with the use of a pipette tube lowered into the blood serum for subsequent release into separate specimen cups. It can readily be understood that either of these two commonly used serum removal methods are subject to sources of contamination. These methods of separation, moreover, are readily subject to contamination of the serum by migrating blood cells unless great care is taken in the separating process. For this reason, several spinnings in a centrifuge are generally necessary in order to obtain a serum sample which lends itself to reliable and valid chemical analysis. This process of separation takes much of the technicians time and, in addition, necessitates the uneconomic use of glassware.

It is, accordingly, the principal object of this invention to providea new and improved blood sampling vacuum syringe, centrifuge container and specimen cup that obviates the above described deficiencies of blood serum specimen preparation devices and procedures heretofore devised.

A more particular object of the invention is to provide a combination blood sampling vacuum syringe, centrifuge container and specimen cup of the character above described that will be of unitary structure including an enclosed blood sample centrifuge container and specimen cup for use with an ordinary tubular needle holder for vacuum drawing a blood sample into the centrifuge container, and which includes means for gravitationally removing a predetermined quantity of subsequently centrifuged blood serum in said container into the specimen cup for analysis upon the manual manipulation of the device in a simple and non-critical manner.

Still another object of the invention is to provide a vacuum syringe device of the above nature wherein the specimen cup forms a separable lower end portion of a housing member in the upper end of which the centrifuge container is disposed in coaxially-spaced relation, the centrifuge container being provided, in an upper side wall portion thereof, with vertically-spaced openings normally sealed off by means of a pressure sensitive tear strip adapted to be removed for sequentially unsealing said openings to permit gravitation of centrifuge blood serum down into the specimen cup.

And yet another object of the invention is to provide a vacuum syringe device in the above nature including means for readily tranversely severing or breaking away the specimen cup end portion of the device housing to permit easy removal of the filled serum specimen cup for laboratory analysis. Quicker and more efficient separation of serum from cells is thus achieved with less labor and a higher degree of accuracy than heretofore possible. i

Yet another object of the invention is to provide a vacuum syringe device of the above nature which will be of such simple and inexpensive construction as to be readily disposable or expendable after use, while at the same time providing under a clean environment a capped blood serum containing specimen cup for interchangeable use in automatic multiple test laboratory analyzers.

Other objects, features and advantages of the invention will be apparent from the following description when read with reference to the accompanying drawings. In the drawings, wherein like reference numerals denote corresponding parts throughout the several views:

FIG. 1 is a longitudinal cross-sectional view of a vacuum syringe device embodying the invention shown partially inserted in a tubular holder preparatory to the taking of a blood sample;

FIG. 2 is a vertical cross-sectional view similar to that of FIG. 1, but showing the vacuum syringe device fully depressed within the needle holder after a blood sample has been taken, and further showing the blood sample which has been withdrawn into chamber of the device;

FIG. 3 is a vertical cross-sectional view of the vacuum syringe device of FIG. 2, shown separately after centrifuging of the blood sample;

FIG. 4 is a longitudinal cross-sectional fiew similar to that of FIG. 3, but showing removal of the associated vent opening tear strip for gravity feed of the centrifuged blood serum into the specimen cup; and

FIG. 5 is a vertical cross-sectional view similar to that of FIG. 4, but showing how the upper.portion of the cylindrical housing of the device can be broken away to separate the serum containing specimen cup.

Referring now in detail to the drawings, reference numeral designates, generally, a combination blood sampling vacuum syringe, centrifuge container and specimen cup embodying the invention, the same being shown, in FIGS. 1 and 2, being used in association with a hollow needle holder 11. The needle holder 11 is of standard known construction, and may be of the type commonly used with ordinary vacuum syringes. As such, it comprises a tubular body portion 12 the lower end of which, as illustrated, is open to receive an evacuated blood collection tube and provided with an outwardly-extending peripheral flange 13 for manual grip and control. The opposite end of the tubular body portion 12 is closed with a bottom wall portion 14 provided with an in internally-threaded axial opening 15 into which a disposable hollow needle assembly or cannibis 16 may be removably fitted in known fashion. The needle assembly 16 comprises an outwardly-extending end 17 for insertion into the patients vein upon the taking of a blood sample, and an inwardly-extending end 18 for piercing the centrifuge chamber of the vacuum syringe device, as is hereinbelow more particularly described.

The vacuum syringe device 10 embodying the invention comprises an elongated cylindrical housing member 19 coaxially jointed at its lower end with a reduced-diameter specimen cup 20 through a short, frusto-conical connector wall portion 21. The cylindrical housing member 19, connector wall portion 21 and specimen cup 20 are preferably integrally formed of a tough, transparent synthetic plastic material. The specimen cup 20 comprises a cylindrical outer wall 22 having an outwardly-extending, peripheral flange 23 near its upper or open end, and a substantially frustoconical bottom wall 24 at its closed or lower end, as i1- lustrated in the drawings. The specimen cup 20 is of a shape typical of those used in automatic blood chemistry analyzers, and therefore constitutes no part of the present invention in and of itself.

Coaxially disposed within the cylindrical housing member 19 is a cylindrical blood sample collecting tube 25 having a rounded bottom wall and being generally in the form of an ordinary test tube. The upper or open end of the collecting tube 25 is hermetically sealed with a diaphragm plug cap member 27 having a radially-extending peripheral upper end flange portion 28 an underside portion of which seats in abutting engagement against the upper edge or rim of the centrifuge said collecting tube. An outer marginal portion of the.

underside of the diaphragm plug cap flange portion 28 seats against the upper open edge of the cylindrical housing member 19 and is affixed thereto in any convenient manner, such as by the use of a suitable adhesive. Alternatively,.a.n annular groove could be formed in the underside of the flange portion 28 to frictionally retain the upper end of the collecting tube in place, The outer diameter of the blood sample collecting tube 25 is of somewhat lesser diameter than the internal diameter of the cylindrical housing member 19 within which it is coaxially disposed to provide spacing therebetween for the purpose hereinafter appearing.

. As is best illustrated in FIG. 5, the blood sample collecting tube'25 is provided in its side wall with a plurality of substantially equidistantly-spaced, verticallyaligned through openings 29, 30, 31, and 32. The uppermost opening 29 is located directly below the inner end of the diaphragm plug cap member 27, whereas the lowermost opening 32 is located a short distance below the longitudinal center of the collection tube 25. The upper through opening29 may be round, while the remaining opening 30, 31 and 32 are preferably triangular with upwardly directed apices, for the purpose hereinafter appearing. Prior to use of the vacuum syringe device, the openings 29 through 32 are sealed off from the outside by means of a separable elongated seal strip 33 the upper end of which terminates in loose pull-tab portion 34.'The seal strip 33 .is retained in place in sealing engagementagainst the outside of the blood sample collection tube 25 and in sealing engagement with respect to the openings 29 through 32 .by use, preferably, of a pressure-sensitive adhesive. To insure that the separable seal strip 33 be impervious to air leakage, it is preferably fabricated of aluminum foil, or the like dense, film-like material strong enough to permit pull away separation from the collecting tube 25 while at the same time being flexible or bendable enough to peal away for successive venting of the openings 29,30, 31 and 32 one at a time, in a controlled manner. An elongated access opening 35, (see FIG. 5), is provided in the side wall of the cylindrical housing member 19, in register with the separable seal strip-33 of the collecting tube 35, to permit manual pulling away of said seal strip in the manner and for the purpose hereinbelow more particularly described.

Considering now the operation of the vacuum syringe device 10, the same will first be fitted loosely in a typical needle holder 11 as described above preparatory to insertion of the outwardly-extending end portion 17 of the needle assembly 16 in the distendedvein of the patient giving the blood sample. As illustrated in FIG. 2, immediately upon insertion of the needle, the blood sample collecting tube 25 will become filled with blood, indicated at B in FIG. 2, drawn inwardly under the influence of the contained vacuum. The vacuum syringe device 10 will thereupon be withdrawn from the needle holder 11, and the diaphragm plug cap 37, being of a resilient material such as natural or synthetic rubber, will seal off the contained blood upon separation from the inwardly-extending needle portion 18.

The blood containing vacuum syringe device 10 is now ready for centrifuging to separate the blood cell mass from the serum, such. separation being illustrated in FIG. 3 by the cells C shown in the lower end portion of the collecting tube 25 and the blood serum, designated S, at the upper end portion of said collecting tube. As illustrated by reference character D in FIGS. 3, 4 and 5, after centrifuging there will be a rather sharp plane of demarcation between the dense blood cell mass C and the now separated blood serum S.

The method and means by which the separated blood serum S in the collecting tube 25 is transferred to the specimen cup 20 will now be described with reference to FIGS. 3 and 4. As illustrated in FIG. 3, the vacuum syringe device will be supported in an upright position and the loose pull-tab 34 at the upper end of the separable seal strip 33 will be grasped between thumb and forefinger and pulled upon gently so as first to open the top vent opening 29 of the collecting tube 25 and thereafter successively open the remaining serum drain openings 30, 31 and 32. As illustrated in FIG. 4, upon the above described openings 29, 30, 31 and 32, being opened, the centrifuged serum S will flow successively through the openings 30, 31 and 32 to trickle down into the specimen cup 20. In this connection, it is to be noted that the lowermost flow opening 32 will be well above the plane of separation D in any centrifuge blood sample to obviate any possibility of serum contamination by blood cells. It is also to be noted that if smaller quantities of centrifuged blood serum are required, the opening of only the first or the first two of the serum flow openings 30 and 31 will provide for such lesser amounts in the specimen cup 20.

As is best illustrated in FIG. 5, means is provided for quickly and easily separating the serum containing specimen cup 20 from the used vacuum syringe device.

To this end, the zone of juncture between the upper end of the specimen cup 20 and the frusto-conical connector wall portion 21 is provided with an annular groove 38 defining a weakened wall zone permitting lateral breakaway upon the imposition of a slightly manually applied twisting and/or bending force upon said specimen tube with respect to the elongated cylindrical housing member 19.

While we have illustrated and described herein only one form in which our invention can conveniently be embodied in practice, it is to be understood that this form is given by way of example only and not in a limiting sense. The invention, in brief, comprises all the embodiments and modifications coming within the scope and spirit of the following claims.

What we claim as new and desire to secure by Letters Patent is:

I. For use with a conventional tubular blood sampling needle holder, a combination holder, centrifuge container and specimen cup comprising, in combination, an elongated tubular housing member, and evacuated blood sample collecting tube, means supporting said collecting tube in spaced relation within one end of said housing member, the outer end of said collecting tube being fitted with a needle pierceable closure cap member, the other end of said housing member being closed, and normally-closed, manually-controlled aperture means in a side-wall portion of the outer end portion of said collecting tube for draining centrifuged blood serum from said collecting tube into the closed end of said housing member and means on said housing member allowing access to said manually-controlled aperture means.

2. The invention as defined in claim 1, wherein said other end of said housing member is in the form of a specimen cup having an open end facing the inner end of said collecting tube in lon 'tudinally-space elation, and means for separating sai specimen cup tom the remainder of said tubular housing member.

3. The invention as defined in claim 2, wherein said aperture means comprises a plurality of vertically aligned openings in said collecting tube, and a pressuresensitive tear strip normally adhered to said collecting tube in sealing relation with respect to said plurality of openings.

4. The invention as defined in claim 3, wherein said means allowing access comprises an elongated opening in said tubular housing member permitting access for manual tearing away of said tear strip.

5. The invention as defined in claim 4, wherein a lowermost sub-plurality of openings of said plurality of openings are of triangular shape.

6. The invention as defined in claim 5, wherein said tubular housing member is integrally formed of a transparent synthetic plastic material.

7. The invention as defined in claim 6, wherein said means for separating comprises a peripheral weakened wall zone at the upper end of said specimen cup to permit manual breakaway thereof after being supplied with a serum specimen.

Claims (7)

1. For use with a conventional tubular blood sampling needle holder, a combination holder, centrifuge container and specimen cup comprising, in combination, an elongated tubular housing member, and evacuated blood sample collecting tube, means supporting said collecting tube in spaced relation within one end of said housing member, the outer end of said collecting tube being fitted with a needle pierceable closure cap member, the other end of said housing member being closed, and normallyclosed, manually-controlled aperture means in a side-wall portion of the outer end portion of said collecting tube for draining centrifuged blood serum from said collecting tube into the closed end of said housing member and means on said housing member allowing access to said manually-controlled aperture means.
2. The invention as defined in claim 1, wherein said other end of said housing member is in the form of a specimen cup having an open end facing the inner end of said collecting tube in longitudinally-space relation, and means for separating said specimen cup from the remainder of said tubular housing member.
3. The invention as defined in claim 2, wherein said aperture means comprises a plurality of vertically aligned openings in said collecting tube, and a pressure-sensitive tear strip normally adhered to said collecting tube in sealing relation with respect to said plurality of openings.
4. The invention as defined in claim 3, wherein said means allowing access comprises an elongated opening in said tubular housing member permitting access for manual tearing away of said tear strip.
5. The invention as defined in claim 4, wherein a lowermost sub-plurality of openings of said plurality of openings are of triangular shape.
6. The invention as defined in claim 5, wherein said tubular housing member is integrally formed of a transparent synthetic plastic material.
7. The invention as defined in claim 6, wherein said means for separating comprises a peripheral weakened wall zone at the upper end of said specimen cup to permit manual breakaway thereof after being supplied with a serum specimen.
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Cited By (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3815579A (en) * 1972-06-05 1974-06-11 S Rose Blood withdrawing means
US3983037A (en) * 1973-11-05 1976-09-28 Jae Yoon Lee Apparatus for transfer, storage, and distribution of liquid
US4012325A (en) * 1975-01-08 1977-03-15 Eastman Kodak Company Biological fluid dispenser and separator
FR2325921A1 (en) * 1975-09-24 1977-04-22 Aesculapius Scient Ltd Bringest improvements to processes and plasma samples of preparation devices and blood serum
US4052320A (en) * 1975-08-29 1977-10-04 Eastman Kodak Company Telescoping serum separator and dispenser
US4091802A (en) * 1976-02-17 1978-05-30 Eastman Kodak Company Vented liquid collection device
EP0058440A1 (en) * 1981-02-10 1982-08-25 DEMATEX DEVELOPMENT & INVESTMENT ESTABLISHMENT Blood collection unit
EP0065187A2 (en) * 1981-05-13 1982-11-24 Olympus Optical Co., Ltd. Plug for closing the forceps inlet of an endoscope
WO1988006861A1 (en) * 1987-03-17 1988-09-22 Uwe Ballies Device for taking blood
WO1990000881A1 (en) * 1988-07-21 1990-02-08 Spencer Treesa A Blood collector cylinder with needle ejector
US5186898A (en) * 1984-03-23 1993-02-16 Applied Biosystems, Inc. Automated polypeptide synthesis apparatus
US5288466A (en) * 1991-06-06 1994-02-22 Becton, Dickinson And Company Blood microcollection tube assembly
US5384096A (en) * 1993-05-12 1995-01-24 Becton, Dickinson And Company Microcollection tube assembly
EP0643944A1 (en) * 1993-09-22 1995-03-22 B. Braun Melsungen Ag Blood sampling device
US5474687A (en) * 1994-08-31 1995-12-12 Activated Cell Therapy, Inc. Methods for enriching CD34+ human hematopoietic progenitor cells
US5556599A (en) * 1992-06-29 1996-09-17 Ahmed; Syed M. Blood sample/fluid system
US5577513A (en) * 1994-08-31 1996-11-26 Activated Cell Therapy, Inc. Centrifugation syringe, system and method
US5646004A (en) * 1994-08-31 1997-07-08 Activated Cell Therapy, Inc. Methods for enriching fetal cells from maternal body fluids
US5648223A (en) * 1994-08-31 1997-07-15 Activated Cell Therapy, Inc. Methods for enriching breast tumor cells
US5663051A (en) * 1994-08-31 1997-09-02 Activated Cell Therapy, Inc. Separation apparatus and method
US5755673A (en) * 1995-12-28 1998-05-26 Bio-Plexus, Inc. Needle holder for fluid collection and/or injection system
US5840502A (en) * 1994-08-31 1998-11-24 Activated Cell Therapy, Inc. Methods for enriching specific cell-types by density gradient centrifugation
US5916814A (en) * 1996-10-09 1999-06-29 Drummond Scientific Company Presealed integral hematocrit test assembly and method
US6247592B1 (en) 1996-06-21 2001-06-19 Bio-Plexus, Inc. System for disposal of contaminated medical products
US20020156439A1 (en) * 1997-09-12 2002-10-24 Michael J. Iskra Collection container assembly
US6805689B2 (en) 2001-10-23 2004-10-19 Wei Chen Safety blood collector device
US20060188942A1 (en) * 2001-02-05 2006-08-24 Micap Plc Detection of Micro-Organisms
US20070036684A1 (en) * 2005-08-10 2007-02-15 Roche Diagnostics Operations, Inc. Sample pick-up and metering device with integrated liquid compartments
US20090014391A1 (en) * 2002-05-03 2009-01-15 Biomet Biologics, Llc Buoy Suspension Fractionation System
US8048321B2 (en) 2002-05-24 2011-11-01 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US8062534B2 (en) 2002-05-24 2011-11-22 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US8119013B2 (en) 2007-04-12 2012-02-21 Hanuman, Llc Method of separating a selected component from a multiple component material
US8187477B2 (en) 2002-05-03 2012-05-29 Hanuman, Llc Methods and apparatus for isolating platelets from blood
US8313954B2 (en) 2009-04-03 2012-11-20 Biomet Biologics, Llc All-in-one means of separating blood components
US8328024B2 (en) 2007-04-12 2012-12-11 Hanuman, Llc Buoy suspension fractionation system
US8337711B2 (en) 2008-02-29 2012-12-25 Biomet Biologics, Llc System and process for separating a material
US8567609B2 (en) 2006-05-25 2013-10-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US8591391B2 (en) 2010-04-12 2013-11-26 Biomet Biologics, Llc Method and apparatus for separating a material
US20140193810A1 (en) * 2013-01-04 2014-07-10 Sony Corporation Liquid injection jig set
US8783470B2 (en) 2009-03-06 2014-07-22 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
US8808551B2 (en) 2002-05-24 2014-08-19 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
WO2014160781A1 (en) * 2013-03-26 2014-10-02 Alliance Partners Llc Biological fluids concentration assembly
US9011800B2 (en) 2009-07-16 2015-04-21 Biomet Biologics, Llc Method and apparatus for separating biological materials
US9556243B2 (en) 2013-03-15 2017-01-31 Biomet Biologies, LLC Methods for making cytokine compositions from tissues using non-centrifugal methods
US9642956B2 (en) 2012-08-27 2017-05-09 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US9701728B2 (en) 2008-02-27 2017-07-11 Biomet Biologics, Llc Methods and compositions for delivering interleukin-1 receptor antagonist

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2649245A (en) * 1947-04-24 1953-08-18 Rudolph Grave Aktiebolag Concentrating vessel and stopper therefor
US2655919A (en) * 1951-04-17 1953-10-20 Charles B Goodstein Hypodermic syringe and cartridge therefor
US2722257A (en) * 1953-02-12 1955-11-01 Compule Corp Sampling tube equipment
US3159159A (en) * 1960-06-01 1964-12-01 Milton J Cohen Fluid withdrawal device and container
US3190547A (en) * 1963-07-29 1965-06-22 Giovanni Raccuglia Method and apparatus for centrifugally fractionating liquid mixtures
US3433216A (en) * 1966-12-22 1969-03-18 Roger P Mattson Self-evacuating fluid sampling device

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2649245A (en) * 1947-04-24 1953-08-18 Rudolph Grave Aktiebolag Concentrating vessel and stopper therefor
US2655919A (en) * 1951-04-17 1953-10-20 Charles B Goodstein Hypodermic syringe and cartridge therefor
US2722257A (en) * 1953-02-12 1955-11-01 Compule Corp Sampling tube equipment
US3159159A (en) * 1960-06-01 1964-12-01 Milton J Cohen Fluid withdrawal device and container
US3190547A (en) * 1963-07-29 1965-06-22 Giovanni Raccuglia Method and apparatus for centrifugally fractionating liquid mixtures
US3433216A (en) * 1966-12-22 1969-03-18 Roger P Mattson Self-evacuating fluid sampling device

Cited By (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3815579A (en) * 1972-06-05 1974-06-11 S Rose Blood withdrawing means
US3983037A (en) * 1973-11-05 1976-09-28 Jae Yoon Lee Apparatus for transfer, storage, and distribution of liquid
US4012325A (en) * 1975-01-08 1977-03-15 Eastman Kodak Company Biological fluid dispenser and separator
US4052320A (en) * 1975-08-29 1977-10-04 Eastman Kodak Company Telescoping serum separator and dispenser
FR2325921A1 (en) * 1975-09-24 1977-04-22 Aesculapius Scient Ltd Bringest improvements to processes and plasma samples of preparation devices and blood serum
US4091802A (en) * 1976-02-17 1978-05-30 Eastman Kodak Company Vented liquid collection device
EP0058440A1 (en) * 1981-02-10 1982-08-25 DEMATEX DEVELOPMENT & INVESTMENT ESTABLISHMENT Blood collection unit
EP0065187A2 (en) * 1981-05-13 1982-11-24 Olympus Optical Co., Ltd. Plug for closing the forceps inlet of an endoscope
EP0065187A3 (en) * 1981-05-13 1983-01-26 Olympus Optical Co., Ltd. Plug for closing the forceps inlet of an endoscope
US5186898A (en) * 1984-03-23 1993-02-16 Applied Biosystems, Inc. Automated polypeptide synthesis apparatus
WO1988006861A1 (en) * 1987-03-17 1988-09-22 Uwe Ballies Device for taking blood
US4907600A (en) * 1987-04-29 1990-03-13 Spencer Treesa A Blood collector cylinder with needle ejector
WO1990000881A1 (en) * 1988-07-21 1990-02-08 Spencer Treesa A Blood collector cylinder with needle ejector
US4993426A (en) * 1988-07-21 1991-02-19 Spencer Teresa A Blood collector cylinder with needle ejector
US5288466A (en) * 1991-06-06 1994-02-22 Becton, Dickinson And Company Blood microcollection tube assembly
US5556599A (en) * 1992-06-29 1996-09-17 Ahmed; Syed M. Blood sample/fluid system
US5384096A (en) * 1993-05-12 1995-01-24 Becton, Dickinson And Company Microcollection tube assembly
US5458854A (en) * 1993-05-12 1995-10-17 Becton, Dickinson And Company Collection assembly
EP0643944A1 (en) * 1993-09-22 1995-03-22 B. Braun Melsungen Ag Blood sampling device
US5840502A (en) * 1994-08-31 1998-11-24 Activated Cell Therapy, Inc. Methods for enriching specific cell-types by density gradient centrifugation
US5577513A (en) * 1994-08-31 1996-11-26 Activated Cell Therapy, Inc. Centrifugation syringe, system and method
US5646004A (en) * 1994-08-31 1997-07-08 Activated Cell Therapy, Inc. Methods for enriching fetal cells from maternal body fluids
US5648223A (en) * 1994-08-31 1997-07-15 Activated Cell Therapy, Inc. Methods for enriching breast tumor cells
US5663051A (en) * 1994-08-31 1997-09-02 Activated Cell Therapy, Inc. Separation apparatus and method
US5474687A (en) * 1994-08-31 1995-12-12 Activated Cell Therapy, Inc. Methods for enriching CD34+ human hematopoietic progenitor cells
US5755673A (en) * 1995-12-28 1998-05-26 Bio-Plexus, Inc. Needle holder for fluid collection and/or injection system
USRE37908E1 (en) * 1995-12-28 2002-11-19 Bio-Plexus, Inc. Needle holder for fluid collection and/or injection system
US6247592B1 (en) 1996-06-21 2001-06-19 Bio-Plexus, Inc. System for disposal of contaminated medical products
US5916814A (en) * 1996-10-09 1999-06-29 Drummond Scientific Company Presealed integral hematocrit test assembly and method
US20020156439A1 (en) * 1997-09-12 2002-10-24 Michael J. Iskra Collection container assembly
US20060188942A1 (en) * 2001-02-05 2006-08-24 Micap Plc Detection of Micro-Organisms
US8956880B2 (en) * 2001-02-05 2015-02-17 Micap Plc Detection of micro-organisms
US6805689B2 (en) 2001-10-23 2004-10-19 Wei Chen Safety blood collector device
US8187477B2 (en) 2002-05-03 2012-05-29 Hanuman, Llc Methods and apparatus for isolating platelets from blood
US20090014391A1 (en) * 2002-05-03 2009-01-15 Biomet Biologics, Llc Buoy Suspension Fractionation System
US8950586B2 (en) 2002-05-03 2015-02-10 Hanuman Llc Methods and apparatus for isolating platelets from blood
US7992725B2 (en) 2002-05-03 2011-08-09 Biomet Biologics, Llc Buoy suspension fractionation system
US8808551B2 (en) 2002-05-24 2014-08-19 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US8163184B2 (en) 2002-05-24 2012-04-24 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
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US8048321B2 (en) 2002-05-24 2011-11-01 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US20070036684A1 (en) * 2005-08-10 2007-02-15 Roche Diagnostics Operations, Inc. Sample pick-up and metering device with integrated liquid compartments
US8303912B2 (en) * 2005-08-10 2012-11-06 Roche Diagnostics Operations, Inc. Sample pick-up and metering device with integrated liquid compartments
US8567609B2 (en) 2006-05-25 2013-10-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US8328024B2 (en) 2007-04-12 2012-12-11 Hanuman, Llc Buoy suspension fractionation system
US9649579B2 (en) 2007-04-12 2017-05-16 Hanuman Llc Buoy suspension fractionation system
US8596470B2 (en) 2007-04-12 2013-12-03 Hanuman, Llc Buoy fractionation system
US9138664B2 (en) 2007-04-12 2015-09-22 Biomet Biologics, Llc Buoy fractionation system
US8119013B2 (en) 2007-04-12 2012-02-21 Hanuman, Llc Method of separating a selected component from a multiple component material
US9701728B2 (en) 2008-02-27 2017-07-11 Biomet Biologics, Llc Methods and compositions for delivering interleukin-1 receptor antagonist
US20130196425A1 (en) * 2008-02-29 2013-08-01 Biomet Biologics, Llc System and Process for Separating a Material
US9719063B2 (en) 2008-02-29 2017-08-01 Biomet Biologics, Llc System and process for separating a material
US8337711B2 (en) 2008-02-29 2012-12-25 Biomet Biologics, Llc System and process for separating a material
US8801586B2 (en) * 2008-02-29 2014-08-12 Biomet Biologics, Llc System and process for separating a material
US8783470B2 (en) 2009-03-06 2014-07-22 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
US8992862B2 (en) 2009-04-03 2015-03-31 Biomet Biologics, Llc All-in-one means of separating blood components
US8313954B2 (en) 2009-04-03 2012-11-20 Biomet Biologics, Llc All-in-one means of separating blood components
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