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US3626950A - Catheter with augmented drainage means - Google Patents

Catheter with augmented drainage means Download PDF

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Publication number
US3626950A
US3626950A US3626950DA US3626950A US 3626950 A US3626950 A US 3626950A US 3626950D A US3626950D A US 3626950DA US 3626950 A US3626950 A US 3626950A
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Prior art keywords
catheter
fins
means
tube
region
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Expired - Lifetime
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Rudolf R Schulte
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Baxter International Inc
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Heyer-Schulte Corp
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0067Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A61M25/007Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/008Drainage tubes; Aspiration tips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/02Holding devices, e.g. on the body
    • A61M25/04Holding devices, e.g. on the body in the body, e.g. expansible
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00Drainage appliances for wounds or the like, i.e. wound drains, implanted drains
    • A61M27/002Implant devices for drainage of body fluids from one part of the body to another
    • A61M2027/004Implant devices for drainage of body fluids from one part of the body to another with at least a part of the circuit outside the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00Drainage appliances for wounds or the like, i.e. wound drains, implanted drains
    • A61M27/002Implant devices for drainage of body fluids from one part of the body to another
    • A61M27/006Cerebrospinal drainage; Accessories therefor, e.g. valves

Abstract

A catheter for the drainage of a region of the human body into which region one end of the catheter is inserted, usually by means of an axial force. Means is provided for augmenting the drainage area of the catheter whereby to minimize clogging by such particulate matter as may be present in the region to be drained. In addition, means may be provided to shroud at least some of the drainage means while the catheter is being thrust into the region. The catheter comprises a pair of flexible fins which surround a catheter tube on each side of a passage through its wall. The passage is an inlet means to the lumen of the tube. These fins are joined to each other at a peripheral junction so as to form a chamber in communication with the passage. A plurality of perforations through at least one of the fins augments the inlet means in the sense of providing an increased total flow channel to the lumen of the tube without requiring enlargement of the passage, which could risk the passage of particulate matter of excessive size.

Description

United States Patent [72] Inventor Rudolf R. Schulte Santa Barbara, Calif. 21 Appl. No. 47,657 [22] Filed June 19, 1970 [45] Patented Dec. 14, 1971 [73] Assignee l-leyer-Schulte Corporation Santa Barbara, Calif. Continuation-impart of application Ser. No. 844,559, July 24, 1969. This application. June 19, 1970, Ser. No. 47,657

[54] CATHETER WITH AUGMENTED DRAINAGE MEANS 5 Claims, 5 Drawing Figs.

[52] US. Cl 128/350 R, 128/245 [51] lnt.Cl A6lm 27/00 [50] Field of Search 128/348, 349 R, 349 B, 350 R, 350 V, 351, 245

[56] References Cited UNITED STATES PATENTS 1,383,502 7/1921 Vultee 128/245 2,470,665 5/1949 Stiehl 128/348 X 2,667,875 2/1954 Wallace 128/349 B 3,173,418 3/1965 Baran Primary Examiner-Dalton L. Truluck AttorneyAngus and Mon ABSTRACT: A catheter for the drainage of a region of the human body into which region one end of the catheter is inserted, usually by means of an axial force. Means is provided for augmenting the drainage area of the catheter whereby to minimize clogging by such particulate matter as may be present in the region to be drained. 1n addition, means may be provided to shroud at least some of the drainage means while the catheter is being thrust into the region. The catheter comprises a pair of flexible fins which surround a catheter tube on each side of a passage through its wall. The passage is an inlet means to the lumen of the tube. These fins are joined to each other at a peripheral junction so as to form a chamber in communication with the passage. A plurality of perforations through at least one of the fins augments the inlet means in the sense of providing an increased total flow channel to the lumen of the tube without requiring enlargement of the passage, which could risk the passage of particulate matter of excessive size.

mzmtnmmm 31626350 INVENTOR. RUDOLF 1Q. SCHULTE BY W i MW A TTOQ/VE Y5.

CATHETER WITH AUGMENTED DRAINAGE MEANS CROSS-REFERENCE TO OTHER PATENT APPLICATION This is a continuation-in-part of applicant's copending U.S. Pat. application, Ser. No. 844,559, filed July 24, 1969, entitled Non-Clogging Catheter."

This invention relates to a catheter for the drainage of fluids from within the human body.

A conventional catheter is a tube with an axially extending lumen which, near one end thereof has a passage in the nature of an inlet port extending between the lumen and the outer wall. After the catheter is thrust in to a region holding unwanted fluids, the fluid may enter the inlet port and flow through the lumen to be disposed of either outside the body or in some region within the body where a further disposal process takes place.

A well-known application for such a catheter is in the alleviation of the symptoms of hydrocephalus. ln such cases, a catheter is thrust into the ventricles of the brain in order to drain unwanted fluid therefrom, and is then led through the jugular vein into the heart so that the fluid from the ventricles enters the blood stream and is disposed of in the process of purification of the blood.

A problem encountered with conventional catheters is that the debris created by its insertion may clog the inlet port during the insertion process. Furthermore, in applications such as in drainage of the brain, the matter of the brain is thrust aside upon insertion and when the brain is decompressed by drainage of the fluid, it tends to bear against the wall of the catheter, thereby potentially clogging the inlet port. Also, the fluids to be drained are frequently burdened with particulate matter which can clog up single openings as so often are provided in conventional catheters. It is an object of this invention to provide means whereby the catheter may be rendered substantially nonclogging and nonoccludable both during the process of insertion and during the time that it remains inside the region to be drained, and also having augmented means whereby to increase the number of drainage ports without weakening the tube and without requiring enlargement of the port itself.

A catheter according to this invention comprises a tube having an internal longitudinal lumen with an inlet port or passage passing through its wall to the lumen. A pair of circumferential flexible fins are attached to the outer wall of the tube on each side of the opening and are connected to each others peripheries so as to form a chamber between them in fluid communication with the inlet port. A plurality of perforations is provided in at least one of the fins and may be provided in both. Advantages are obtained when only that one of the fins of each pair which is the farther from the tip is perforated.

The above and other features of this invention will be fully understood from the following detailed description and the accompanying drawings in which:

FIG. 1 is a perspective drawing showing the presently preferred embodiment of this invention together with a tool for its insertion;

F l6. 2 is a perspective drawing partly in cutaway cross section showing the catheter of the invention in the process of being inserted into the brain;

FIG. 3 shows the device of F I68. 1 and 2 in the brain;

FIG. 4 is a cross section taken at 4-4 ofFIG. l; and

FIG. 5 is a axial cross section taken at line 5-5 of FIG. 2.

The presently preferred embodiment of the invention is shown in F lG. 1 wherein a catheter is shown which includes an elongated tube 11 having a central lumen 12 comprising a cylindrical interior bore ending at a closed tip 13.

Drainage means 14 comprising a laterally extending hole extending between the lumen 12 and outer wall 15 of the tube is provided to permit fluid from outside the tube to be drained to the internal lumen and thus to be removed from the body. In the prior art, such drainage means (hereinafter frequently referred to as drain ports) have been all the openings which exist, and these have been subject to clogging by particulate matter contained in the fluid to be drained and also by contact with the surrounding tissue which has been pushed aside upon insertion of the catheter itself.

It is an object of this invention to increase the drainage cross section of the drainage means without, however, permitting passage of very large particulate matter which downstream in the heart or in the jugular vein might cause distress or damage to the person. For example, were ports 14 to be made quite large and large particulate matter to be discharged into the heart, then damage to the heart valves, or occlusion of various ones of the veins and arteries might occur which could cause a stroke. in the instant device, an augmented drainage cross section is provided without increasing the risk of passage of particulate solid material.

Furthermore, this is accomplished while still providing, if desired, means for shrouding the ports 14 during the time when the catheter is forced into the region which it is to drain.

According to this invention, a pair of circumferential fins 20, 21 are bonded to, or otherwise formed integrally with, outer wall 15. These include annular disclike surfaces which are joined at their outer peripheral edges 22, 23 respectively by cementing or fusion so as to form inside chambers 24, which chambers are in fluid communication with respective ones of ports 14.

Either one or both of each pair of fins is provided with perforations 25 to provide for admission of fluids from the surrounding region into the chamber. According to a preferred but optional feature of the invention, and as best shown in FIG. 5, these perforations are provided only in the fins which are on the opposite side of the tip from the other member of the respective pair of fins.

Accordingly, with reference to FIGS. 2 and 5, when the catheter is thrust into brain 30 through a hole 31 formed in the skull 32 by axial force exerted on the end of a thrust rod 33, the fins will be deflected rearwardly, and those which are exposed to the material of the brain will shroud the perforations. Thereafter when pressure is relieved, and as best shown in FIG. 3 the material of the catheter will spring back and the fins will restore themselves to their generally annular shape, thereby exposing their perforations to fluid in the brain.

It will thereby be understood that this device provides a means optionally for shrouding the perforations of the catheter upon insertion into the brain or the region to be drained, and thereafter when the means for insertion is removed, to provide an augmented inlet means such that a particle of material might clog up one perforation, but not the inlet passage, so that the device is not disabled. The perforations in the fins would preferably be smaller than the diameter of port 14. The entire structure is preferably made of medical grade silicone rubber, and joined as appropriate by a similar type of cement. I

This invention is not to be limited by the embodiment shown in the drawings and described in this description which is given by way of example and not of limitation but only in accordance with the appended claims.

lclaim:

1. A catheter for the drainage of fluid such as hydrocephalus fluid from the region of the human body into which the catheter is inserted by an axial force exerted at its tip end, which region contains substances likely to close or to clog the catheter such as by dislodged debris or by occlusion occasioned by abutment of matter in said region, said catheter comprising: a tube having an internal longitudinal lumen, an outer peripheral wall, a closed tip end, an inlet port space from the tip end and passing through said outer wall to said lumen, a first and a second flexible fin each making a full peripheral sealing contact with the outer peripheral wall and extending entirely around the tube, the first fin being disposed on the side of the inlet port closer to the tip end, and the second fin being disposed on the opposite side thereof, the fins being joined peripherally to form a chamber between them and the said outer wall, said chamber structure formed by the fins being springly flexible so as to exert springback force against a surrounding environment, thereby to maintain the fins in their general shape of a double ended frustoconical member, said chamber being in fluid communication with the said inlet port, one of the fins having a plurality of perforations therethrough to admit fluid into said chamber, said tube being further provided with a plurality of such chambers and inlet ports, identical to that defined above, spaced-apart axially along said tube.

2. A catheter according to claim 1 in which the said perfrations are formed in the said second fin, whereby when the

Claims (5)

1. A catheter for the drainage of fluid such as hydrocephalus fluid from the region of the human body into which the catheter is inserted by an axial force exerted at its tip end, which region contains substances likely to close or to clog the catheter such as by dislodged debris or by occlusion occasioned by abutment of matter in said region, said catheter comprising: a tube having an internal longitudinal lumen, an outer peripheral wall, a closed tip end, an inlet port space from the tip end and passing through said outer wall to said lumen, a first and a second flexible fin each making a full peripheral sealing contact with the outer peripheral wall and extending entirely around the tube, the first fin being disposed on the side of the inlet port closer to the tip end, and the second fin being disposed on the opposite side thereof, the fins being joined peripherally to form a chamber between them and the said outer wall, said chamber structure formed by the fins being springly flexible so as to exert springback force against a surrounding environment, thereby to maintain the fins in their general shape of a double ended frustoconical member, said chamber being in fluid communication with the said inlet port, one of the fins having a plurality of perforations therethrough to admit fluid into said chamber, said tube being further provided with a plurality of such chambers and inlet ports, identical to that defined above, spaced-apart axially along said tube.
2. A catheter according to claim 1 in which the said perforations are formed in the said second fin, whereby when the catheter is thrust into said region by an endwise force, the fin folds and shrouds the perforations in the said second fin.
3. A catheter according to claim 1 in which said perforations are formed in both the said fins.
4. A catheter according to claim 1 in which the fins and the tube are made of silicone rubber.
5. A catheter according to claim 4 in which the fins and the tube are connected together with the silicone adhesive so as to form a substantially continuous body.
US3626950A 1970-06-19 1970-06-19 Catheter with augmented drainage means Expired - Lifetime US3626950A (en)

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Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2232334A1 (en) * 1973-06-07 1975-01-03 Rhone Poulenc Sa Medical probe for body cavity drainage - location assisted by outwardly projecting sloping fingers
US4182343A (en) * 1976-10-05 1980-01-08 President of Tokyo Medical and Dental University Double coeliac drainage tube made of silicone
US4349029A (en) * 1980-06-16 1982-09-14 Mott Patricia A Drainage balloon catheter system
US4378797A (en) * 1980-04-14 1983-04-05 Thomas Jefferson University Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4445887A (en) * 1982-03-03 1984-05-01 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4445500A (en) * 1982-03-03 1984-05-01 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4446155A (en) * 1982-03-03 1984-05-01 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4445514A (en) * 1980-04-14 1984-05-01 Thomas Jefferson University Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4445888A (en) * 1982-03-03 1984-05-01 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4445886A (en) * 1980-04-14 1984-05-01 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4446154A (en) * 1982-03-03 1984-05-01 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4451251A (en) * 1982-03-03 1984-05-29 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4450841A (en) * 1982-03-03 1984-05-29 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
EP0113489A1 (en) * 1983-01-07 1984-07-18 N.U.S. S.r.l. Catheter for medical-surgical application
US4637388A (en) * 1984-10-15 1987-01-20 Portex, Inc. Tracheal tube obturator with reversible tip
US4655745A (en) * 1985-07-29 1987-04-07 Corbett Joseph E Ventricular catheter
US4657532A (en) * 1985-07-19 1987-04-14 Thomas Jefferson University Intra-peritoneal perfusion of oxygenated fluorocarbon
US4686085A (en) * 1980-04-14 1987-08-11 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4758431A (en) * 1980-04-14 1988-07-19 Thomas Jefferson University Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4795423A (en) * 1980-04-14 1989-01-03 Thomas Jefferson University Oxygenated perfluorinated perfusion of the ocular globe to treat ischemic retinopathy
US4830849A (en) * 1980-04-14 1989-05-16 Thomas Jefferson University Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4840617A (en) * 1980-04-14 1989-06-20 Thomas Jefferson University Cerebral and lumbar perfusion catheterization apparatus for use in treating hypoxic/ischemic neurologic tissue
EP0335238A1 (en) * 1988-03-31 1989-10-04 Fresenius AG Catheter for organ perfusion
US4950232A (en) * 1987-08-11 1990-08-21 Surelab Superior Research Laboratories Cerebrospinal fluid shunt system
US5163924A (en) * 1986-08-26 1992-11-17 Michael Beverly Implantable bone drain
EP0522008A1 (en) * 1990-03-29 1993-01-13 Robert S Herrick Canalicular implant having collapsible section.
US6585689B1 (en) * 1997-12-08 2003-07-01 Cardeon Corporation Aortic catheter and methods for inducing cardioplegic arrest and for selective aortic perfusion
US20040082861A1 (en) * 2001-10-17 2004-04-29 Terumo Cardiovascular Systems Corporation Steerable infrared imaging catheter having steering fins
US6936222B2 (en) 2002-09-13 2005-08-30 Kenneth L. Franco Methods, apparatuses, and applications for compliant membrane blood gas exchangers
US20080142005A1 (en) * 2005-05-10 2008-06-19 Ralf Schnell Insertion Aid for Percutaneous Tracheostomy
US20080154173A1 (en) * 2002-02-25 2008-06-26 Novashunt Ag Vesicular shunt for the drainage of excess fluid
US20080287910A1 (en) * 2007-05-14 2008-11-20 Picha George J Intramedullary access or infusion devices
US20080306467A1 (en) * 2005-02-03 2008-12-11 Boris Reydel Method and Devices for Selective Endoscopic Retrograde Cholangiopancreatography
US20090187083A1 (en) * 2008-01-18 2009-07-23 Plaquetec Ltd. Catheter
US20090318844A1 (en) * 2003-11-03 2009-12-24 Novashunt Ag Implantable fluid management device for the removal of excess fluid
US7651529B2 (en) * 2003-05-09 2010-01-26 Boston Scientific Scimed, Inc. Stricture retractor
US7909790B2 (en) 2002-02-25 2011-03-22 Novashunt Ag Implantable fluid management system for the removal of excess fluid
CN104383616A (en) * 2014-12-10 2015-03-04 中国人民解放军第四军医大学 Drainage device used for subdural hematoma
US9694166B2 (en) 2002-03-26 2017-07-04 Medtronics Ps Medical, Inc. Method of draining cerebrospinal fluid

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US1383502A (en) * 1920-09-03 1921-07-05 Charles F L Vultee Vaginal syringe
US2470665A (en) * 1947-07-08 1949-05-17 Stiehl Charles William Suction apparatus
US2667875A (en) * 1951-03-30 1954-02-02 American Cystoscope Makers Inc Inflatable retention catheter
US3173418A (en) * 1961-01-10 1965-03-16 Ostap E Baran Double-wall endotracheal cuff
US3421510A (en) * 1966-01-10 1969-01-14 Edward L Kettenbach Drain having shielded suction tube
US3516410A (en) * 1968-01-03 1970-06-23 Salomon Hakim Cerebro-ventricular catheter

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1383502A (en) * 1920-09-03 1921-07-05 Charles F L Vultee Vaginal syringe
US2470665A (en) * 1947-07-08 1949-05-17 Stiehl Charles William Suction apparatus
US2667875A (en) * 1951-03-30 1954-02-02 American Cystoscope Makers Inc Inflatable retention catheter
US3173418A (en) * 1961-01-10 1965-03-16 Ostap E Baran Double-wall endotracheal cuff
US3421510A (en) * 1966-01-10 1969-01-14 Edward L Kettenbach Drain having shielded suction tube
US3516410A (en) * 1968-01-03 1970-06-23 Salomon Hakim Cerebro-ventricular catheter

Cited By (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2232334A1 (en) * 1973-06-07 1975-01-03 Rhone Poulenc Sa Medical probe for body cavity drainage - location assisted by outwardly projecting sloping fingers
US4182343A (en) * 1976-10-05 1980-01-08 President of Tokyo Medical and Dental University Double coeliac drainage tube made of silicone
US4445886A (en) * 1980-04-14 1984-05-01 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4758431A (en) * 1980-04-14 1988-07-19 Thomas Jefferson University Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4378797A (en) * 1980-04-14 1983-04-05 Thomas Jefferson University Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4686085A (en) * 1980-04-14 1987-08-11 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4840617A (en) * 1980-04-14 1989-06-20 Thomas Jefferson University Cerebral and lumbar perfusion catheterization apparatus for use in treating hypoxic/ischemic neurologic tissue
US4445514A (en) * 1980-04-14 1984-05-01 Thomas Jefferson University Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4830849A (en) * 1980-04-14 1989-05-16 Thomas Jefferson University Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4795423A (en) * 1980-04-14 1989-01-03 Thomas Jefferson University Oxygenated perfluorinated perfusion of the ocular globe to treat ischemic retinopathy
US4349029A (en) * 1980-06-16 1982-09-14 Mott Patricia A Drainage balloon catheter system
US4446154A (en) * 1982-03-03 1984-05-01 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4445888A (en) * 1982-03-03 1984-05-01 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4450841A (en) * 1982-03-03 1984-05-29 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4445887A (en) * 1982-03-03 1984-05-01 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4446155A (en) * 1982-03-03 1984-05-01 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4445500A (en) * 1982-03-03 1984-05-01 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4451251A (en) * 1982-03-03 1984-05-29 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4645493A (en) * 1983-01-07 1987-02-24 N.U.S. S.R.L. Catheter for medical-surgical application
JPH0354729Y2 (en) * 1983-01-07 1991-12-04
EP0113489A1 (en) * 1983-01-07 1984-07-18 N.U.S. S.r.l. Catheter for medical-surgical application
JPS59169840U (en) * 1983-01-07 1984-11-13
US4637388A (en) * 1984-10-15 1987-01-20 Portex, Inc. Tracheal tube obturator with reversible tip
US4657532A (en) * 1985-07-19 1987-04-14 Thomas Jefferson University Intra-peritoneal perfusion of oxygenated fluorocarbon
US4655745A (en) * 1985-07-29 1987-04-07 Corbett Joseph E Ventricular catheter
US5163924A (en) * 1986-08-26 1992-11-17 Michael Beverly Implantable bone drain
US4950232A (en) * 1987-08-11 1990-08-21 Surelab Superior Research Laboratories Cerebrospinal fluid shunt system
EP0335238A1 (en) * 1988-03-31 1989-10-04 Fresenius AG Catheter for organ perfusion
EP0522008A1 (en) * 1990-03-29 1993-01-13 Robert S Herrick Canalicular implant having collapsible section.
EP0522008A4 (en) * 1990-03-29 1993-07-28 Robert S. Herrick Canalicular implant having collapsible section and method
US6585689B1 (en) * 1997-12-08 2003-07-01 Cardeon Corporation Aortic catheter and methods for inducing cardioplegic arrest and for selective aortic perfusion
US20040082861A1 (en) * 2001-10-17 2004-04-29 Terumo Cardiovascular Systems Corporation Steerable infrared imaging catheter having steering fins
US6925320B2 (en) * 2001-10-17 2005-08-02 Terumo Corporation Steerable catheter having steering fins
US9421347B2 (en) 2002-02-25 2016-08-23 Sequana Medical Ag Implantable fluid management system for the removal of excess fluid
US8394048B2 (en) 2002-02-25 2013-03-12 Sequana Medical Ag Vesicular shunt for the drainage of excess fluid
US9913968B2 (en) 2002-02-25 2018-03-13 Sequana Medical Ag Implantable fluid management system for the removal of excess fluid
US20080154173A1 (en) * 2002-02-25 2008-06-26 Novashunt Ag Vesicular shunt for the drainage of excess fluid
US20110178455A1 (en) * 2002-02-25 2011-07-21 Burnett Daniel R Implantable fluid management system for the removal of excess fluid
US8882699B2 (en) 2002-02-25 2014-11-11 Sequana Medical Ag Implantable fluid management system for the removal of excess fluid
US8517973B2 (en) 2002-02-25 2013-08-27 Sequana Medical Ag Implantable fluid management system for the removal of excess fluid
US7909790B2 (en) 2002-02-25 2011-03-22 Novashunt Ag Implantable fluid management system for the removal of excess fluid
US9694166B2 (en) 2002-03-26 2017-07-04 Medtronics Ps Medical, Inc. Method of draining cerebrospinal fluid
US20050281705A1 (en) * 2002-09-13 2005-12-22 Kenneth Franco Methods, apparatuses, and applications for compliant membrane blood gas exchangers
US6936222B2 (en) 2002-09-13 2005-08-30 Kenneth L. Franco Methods, apparatuses, and applications for compliant membrane blood gas exchangers
US8409502B2 (en) 2002-09-13 2013-04-02 Kenneth L. Franco Methods, apparatuses, and applications for compliant membrane blood gas exchangers
US7651529B2 (en) * 2003-05-09 2010-01-26 Boston Scientific Scimed, Inc. Stricture retractor
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