US3623475A - Blood collector device - Google Patents

Blood collector device Download PDF

Info

Publication number
US3623475A
US3623475A US843096A US3623475DA US3623475A US 3623475 A US3623475 A US 3623475A US 843096 A US843096 A US 843096A US 3623475D A US3623475D A US 3623475DA US 3623475 A US3623475 A US 3623475A
Authority
US
United States
Prior art keywords
funnel
end
portion
device according
integral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US843096A
Inventor
Manuel Sanz
Georges Revillet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ICN MICROMEDIC SYSTEMS Inc 3300 HYLAND AVENUE COSTA MESA CALIFORNIA 92626 A CORP OF CALIFORNIA
Rohm and Haas Co
Original Assignee
Micromedic Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CH1127268A priority Critical patent/CH500707A/en
Priority to CH875869A priority patent/CH522395A/en
Application filed by Micromedic Systems Inc filed Critical Micromedic Systems Inc
Priority to US84309669A priority
Application granted granted Critical
Publication of US3623475A publication Critical patent/US3623475A/en
Assigned to ROHM & HAAS COMPANY reassignment ROHM & HAAS COMPANY MERGER (SEE DOCUMENT FOR DETAILS). Assignors: MICROMEDIC SYSTEMS, INC.
Assigned to ROHM & HAAS COMPANY (MERGED WITH AND INTO) reassignment ROHM & HAAS COMPANY (MERGED WITH AND INTO) RE-RECORD OF AN INSTRUMENT RECORDED OCT. 6, 1980, REEL 3804, FRAMES 837-840, TO SHOW NEW OWNER OF SAID PATENTS Assignors: MICROMEDIC SYSTEMS, INC.
Assigned to ICN MICROMEDIC SYSTEMS, INC., 3300 HYLAND AVENUE, COSTA MESA, CALIFORNIA, 92626, A CORP OF CALIFORNIA reassignment ICN MICROMEDIC SYSTEMS, INC., 3300 HYLAND AVENUE, COSTA MESA, CALIFORNIA, 92626, A CORP OF CALIFORNIA ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: MICROMEDIC SYSTEMS, INC., A CORP OF DE.
Anticipated expiration legal-status Critical
Application status is Expired - Lifetime legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150977Arrays of piercing elements for simultaneous piercing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150015Source of blood
    • A61B5/150022Source of blood for capillary blood or interstitial fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150053Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061Means for enhancing collection
    • A61B5/150068Means for enhancing collection by tissue compression, e.g. with specially designed surface of device contacting the skin area to be pierced
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150343Collection vessels for collecting blood samples from the skin surface, e.g. test tubes, cuvettes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381Design of piercing elements
    • A61B5/150412Pointed piercing elements, e.g. needles, lancets for piercing the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150748Having means for aiding positioning of the piercing device at a location where the body is to be pierced
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/151Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101Details
    • A61B5/15103Piercing procedure
    • A61B5/15107Piercing being assisted by a triggering mechanism
    • A61B5/15113Manually triggered, i.e. the triggering requires a deliberate action by the user such as pressing a drive button
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/151Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101Details
    • A61B5/15115Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
    • A61B5/15117Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising biased elements, resilient elements or a spring, e.g. a helical spring, leaf spring, or elastic strap
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150175Adjustment of penetration depth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381Design of piercing elements
    • A61B5/150442Blade-like piercing elements, e.g. blades, cutters, knives, for cutting the skin

Abstract

A tube for use in the automatic collection of a digital blood sample has its mouth fitted with a resilient detachable funnel member which can carry a capillary cannula and in which is held an absorbent annular plug through which pass and project two incisor lancets.

Description

United States Patent [72] Inventors Manuel Sanz Grand-Lancy, Geneva; Georges Revillet, Petit-Lancy, Geneva, both of Switzerland [21] Appl. No. 843,096 [22] Filed July 18, 1969 [45] Patented Nov. 30, 1971 [73] Assignee Micromedlcsystems, Inc.

Philadelphia, Pa.

[ 54] BLOOD COLLECTOR DEVICE 8 Claims, 13 Drawing Figs.

[52] US. Cl 128/2 R, l28/D1G. 5, 128/276, 128/253 [51] Int.Cl A6lb5/l4 [50] Field of Search a 128/2, 275, 253, 314, 315, 333, 276, D16. 5

[56] References Cited UNITED STATES PATENTS 3,063,451 11/1962 Kowalk 128/221 3,134,380 5/1964 Armao 128/253 UX 3,322,121 5/1967 Banker 128/253 3,369,708 2/1968 Hein 128/253 UX 3,433,216 3/1969 Mattson 128/2 FOREIGN PATENTS 84,897 7/1921 Austria 128/D1G. 5 771,890 8/1934 France 128/276 412,124 6/1934 Great Britain 128/333 1,080,986 8/1967 Great Britain 128/253 Primary Examiner-Richard A. Gaudet Assistant Examinerl(yle L. Howell AnorneysGeorge W. F. Simmons, Arthur R. Eglington and Gerry J. Elman ABSTRACT: A tube for use in the automatic collection of a digital blood sample has its mouth fitted with a resilient detachable funnel member which can carry a capillary cannula and in which is held an absorbent annular plug through which pass and project two incisor lancets.

3\ s 4 IO 4 7 4a 7 f z z I I I I 6 I j a 9 C E a 2 u PATENTEBuuv 30 I971 SHEET 1 OF 3 mhufdlffflfiff/f & h

FIG.

F IG.

PATENTED NOV 3 0 I971 SHEET 2 BF 3 in a test tube, in a capillary tube, or by suction into a tube.

These different stages in the taking of a blood sample are usually carried out by qualified personnel who are now becoming more and more scarce.

It is therefore evident that considerable advantages would ensue from the provision of apparatus permitting a blood sample to be taken automatically by the subject and without the necessity of any intervention by a specialist personnel.

An object of the invention is to contribute to the creation of such apparatus and with this object in mid, the invention provides a device for collecting a percutaneous digital blood sam- In the accompanying diagrammatic drawings:

FIG. I is a sectional elevation of a first form of embodiment;

FIG. 2 is a similar view showing the method of making an incision;

FIG. 3 is a perspective view ofa detail ofFIG. 1;

FIG. 4 is a sectional elevation of a second embodiment; FIG. Sis a sectional elevation ofa second embodiment;

FIG. 6 is a part view of the tube used in FIG. filled with blood;

FIGS. 7 and 8 show the tube used in FIG. 5;

FIG. 9 is a sectional elevation ofa fourth embodiment; and

FIGS. 10 to 13 are diagrammatic sectional views, in different operating positions, of various parts of an automatic blood sampling apparatus making use ofa device of the kind shown in FIGS. 1 to 9.

The device shown in FIG. I of the drawing comprises a tubular body 1 of a transparent or translucent material, for extwo different constructional forms for groove 5 forming a passage which allows air to escape as the tubular body 1 is being filled with blood.

At the lower end of plug 2 there projects a capillary cannula 6 extending nearly to the bottom of the body 1, coaxial with said body and forming an extension of an axial passage in the plug 2.

posite sides of a slot 9 in said plate.

Above the plate 7 in the cup 4 is arranged an annular pad 10 of absorbent material, for example, blotting paper, and held in The part of the lancets 8a and 8b that projects above the pad 10 has a length of at least 2 to 3 mm.; these lancets may extend further but not beyond the level of the upper rim of cup 4.

The lancets 8a and 8b are intended to form the cutaneous incisions that have to be made for taking a blood sample (FIG. 2) and it is clearly necessary that these incisions should be sufficiently deep to reach blood vessels of some importance. The actual procedure for obtaining a blood sample will be described below with reference to FIGS. 10 to 13.

The device shown in FIG. 5 differs from that shown in FIG.

carry a cannula 6, and secondly in that the air in the tubular body 1 is discharged through a passage 1] formed in and coaxially with the base of the body 1. This passage 11 passes through a tubular element 12 which is integral with the body 1 its wall is crushed by means which can be tightened as by crimping (FIG. 6).

By way of modification, when the body 1 or at least part of the tubular element 12 is of thermoplastic material, the passage 11 can be closed off by partial fusion of the element 12 (FIG. 7).

point and low elasticity, the by the insertion of a simple stopper 13A (FIG. 8), preferably of compressible material.

The FIG. 9 embodiment differs from that shown in FIG. 1 or FIG. 4, in that the lancets, here identified 14a and 14b, that are provided in the cup 4 are integral with the upper end of the axial passage of plug 2, the lancets and the cannula 15 forming a single metallic body, for example of stainless steel.

FIGS. 10 to 13 illustrate one form of automatic blood sampling apparatus making use of the kind of device shown in FIGS. 1 to 9.

This apparatus comprises a casing 16 of rectangular section in the upper left hand part of which, as seen in FIG. 10, is pivotably mounted at 17 a lever 18 having two parallel arms 18a of which only one can be seen, connected together by a common part 18b covered on its internal surface with a pad of synthetic sponge 19, each arm 18a extending through a slot 16a provided in the left hand face and the upper face of casing 16.

The free end of each arm and the positions of their pivotal points are such that the paths of the tip of beak 18c and the tip of lever 25 intersect one another over a defined length.

Levers 25 bears on the head 29 of a to the action of a spring 31 and slidably mounted in a hole Between the tubular member 32 and the slot 16a, the apparatus casing 16 carries a fixed block 33 of trapezoidal section and acting as an aid for correctly positioning on the apparatus a finger from which a blood sample is to be taken.

On the same face of the apparatus casing 16, on the side of member 32 opposite block 33, there projects, through a slot I611, a massaging block 34 mounted at the end of a lever 35 pivoted at 36 on a link 37 rigid with a shaft 38 which by means of a motor (not shown) can be rotatably driven in an anticlockwise direction as seen in the drawing. As shown in FIG. 1 l, the position of the block 34 on the casing issuch that when the subject from whom a blood sample is to be taken places one of his fingers on the block 33 and lever 18 has been swung down, the pad 19 of lever 18 comes to bear on the part of the finger opposite block 34.

When a blood sample is about to be taken, the various parts of the apparatus described occupy the positions shown in FIG. 10.

A blood collector device E is then placed within the tubular member 32 and pushed until its funnel member is flush with the upper opening of said member.

The subject then lays his hand on the upper face of easing I6 and places the finger to be bled on the massage block 34 with the tip of the finger against the locating block 33 in such a way that the distal part of the finger underlying the nail rests on the rim of the funnel member, as shown in FIG. 11. The area of the finger where the incisions are to be made will, of course, have been previously cleaned and disinfected in an appropriate manner.

All that is then required is to swing lever 18 downwards to bring it into the locked position shown in FIGS. 12. and 13 in order for the necessary incisions to be made in the epidermis of the finger from which a blood sample has to be taken, since this movement of lever 18 causes the beak 180 to bear on lever 25, thereby depressing the latter to compress spring 31, this cooperation between beak 18c and lever continuing as long as the curvilinear paths of their tips intersect one another FIG. 1 l

When these two paths cease to intersect, lever 25 is freed from engagement with beak 18c and then suddenly finds itself subjected to the sole action of the compressed spring 31 which pushes it abruptly against the base of the tubular body of the blood collector device E (FIG. 12).

This body is then correspondingly pushed in the direction of the finger, causing it to slide within the tubular member 32 and to deform the cup 4 of the funnel member 3 (FIG. 2) on which the finger tip bears, and hence to drive the lancets 8a and 8b into the latter to produce the required incisions of the epidermis and dermis.

As soon as the kinetic energy communicated to the tubular body of the blood collector device by percussionhas been dissipated, partly by deformation of cup 4 and partly by the formation of the incision, the tubular body of the blood collector device is urged back to the lowered position shown in FIG. 13 under the action of the cup 4 which acts as a resilient return member upon resuming its original shape. As the tips of the lancets extend at most to the level of the rim of cup 4 when the latter is not deformed, the lancets will clearly be completely withdrawn from the incisions they have made when the cup resumes its position of rest so that it is then possible to proceed to collect a blood sample without the subject feeling any impediment or pain.

To obtain a blood sample, shaft 38 is set in rotation and this rotation imparts an eccentric movement to lever 35 and consequently an undulatory movement to the massage block 34, alternately towards the stationary block 33 during an ascending phase and in the opposite direction during a descending phase (FIG. 13).

As the finger of the subject is gripped between the pad 19 and the block 34, this undulatory movement of the block 34 can only take place by cyclically compressing the underside of the finger from the rear towards the front thereby performing a massage of the digital tissue and hence a periodic flow of blood towards the percutaneous incisions.

The blood issuing from these incisions flows first into cup 4 (FIG. 1) and then through cannula 6 into the tubular body I, the air in this body escaping through groove 5 as filling proceeds.

It is to be noted that the first few drops of blood entering the cup are not collected in the tubular body 1 but are absorbed by the absorbent paper pad 10, as these drops of blood contain a very high proportion of physiological liquid which originates from the subcutaneous cells and which is clearly undesirable in a blood sample.

Thus it is only when the pad 10 ha been sufiiciently impregnated with a mixture of physiological liquid and blood, that the blood issuing from the finger will be more suitable for sampling and it is this blood that will flow into the tubular body 1. In this connection it is to be noted that the lancets considerably facilitate this flow because, although removed from the epidermis they lie directly opposite the incisions and are at a very short distance from them so that the drops of blood issuing from the incisions fall on and are ruptured by the tips of the lancets and then flow rapidly over the surface of the latter into the cannula 6. The lancets thus play the part of effective collectors preventing the formation of a thick blood dispersion in the cup 4.

The massage performed by the movement of the block 4 is, of course, interrupted when the blood in the tubular body 1 reaches a desired level.

At that point the relay 23 is energized to release lever 18 which then frees the finger. The filled blood collector device E is then manually removed from the tubular member 32, whereupon the funnel member 3 and associated cannula 6 are removed from the tubular body 1. The latter is then closed by a suitable stopper in order to prevent coagulation of the blood collected, in particular when it is not to be subjected to an immediate examination.

We claim:

I. A device for collecting a percutaneous digital blood sample comprising a tubular body fixedly closed at one end and open at the other end and adapted to collect the blood, a funnel member having a resilient funnel portion and a discharge end comprising an annular portion with a passage therethrough and engaged at its discharge end in the open end of said body and supported by an annular zone of its lateral surface on the rim of said open end, a mass of absorbent material located within said funnel portion, and at least one incisor lancet in said funnel portion projecting through and beyond said mass and located wholly within said funnel member and means associated with said funnel member to allow air entrapped within said body to vent.

2. A device according to claim I, and including a capillary tube forming an extension of said annular portion and extending to a location adjacent the closed end of the tubular body.

3. A device according to claim 2, wherein one end of the capillary tube is located within the passage in said annular portion, and is integral with said lancet 4. A device according to claim 2, wherein the capillary tube is integral with the funnel portion.

5. A device according to claim 1 and including a base plate supported in a lower part of said funnel portion, the lancet being integral with said base plate.

6. A device according to claim 1, wherein the means for allowing entrapped air to vent comprises a passage located in a lower part of the body and communicating with a tubular element integral with said lower part and projecting beyond said part, said device further comprising a closure means for closing said element.

7. A device according to claim 1, wherein the funnel member is secured in a fluidtight manner within the open end of the tubular body and said means for allowing air to vent comprising a passage located in the periphery of said annular portion and the base of said funnel portion.

8. A device as in claim 1 wherein said annular portion is constructed of resilient material and is integral with said funnel portion.

Claims (8)

1. A device for collecting a percutaneous digital blood sample comprising a tubular body fixedly closed at one end and open at the other end and adapted to collect the blood, a funnel member having a resilient funnel portion and a discharge end comprising an annular portion with a passage therethrough and engaged at its discharge end in the open end oF said body and supported by an annular zone of its lateral surface on the rim of said open end, a mass of absorbent material located within said funnel portion, and at least one incisor lancet in said funnel portion projecting through and beyond said mass and located wholly within said funnel member and means associated with said funnel member to allow air entrapped within said body to vent.
2. A device according to claim 1, and including a capillary tube forming an extension of said annular portion and extending to a location adjacent the closed end of the tubular body.
3. A device according to claim 2, wherein one end of the capillary tube is located within the passage in said annular portion, and is integral with said lancet.
4. A device according to claim 2, wherein the capillary tube is integral with the funnel portion.
5. A device according to claim 1 and including a base plate supported in a lower part of said funnel portion, the lancet being integral with said base plate.
6. A device according to claim 1, wherein the means for allowing entrapped air to vent comprises a passage located in a lower part of the body and communicating with a tubular element integral with said lower part and projecting beyond said part, said device further comprising a closure means for closing said element.
7. A device according to claim 1, wherein the funnel member is secured in a fluidtight manner within the open end of the tubular body and said means for allowing air to vent comprising a passage located in the periphery of said annular portion and the base of said funnel portion.
8. A device as in claim 1 wherein said annular portion is constructed of resilient material and is integral with said funnel portion.
US843096A 1968-07-26 1969-07-18 Blood collector device Expired - Lifetime US3623475A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CH1127268A CH500707A (en) 1968-07-26 1968-07-26 Device for performing percutaneous and taking digital blood
CH875869A CH522395A (en) 1968-07-26 1968-07-26 Test tube for taking blood percutaneous and digital
US84309669A true 1969-07-18 1969-07-18

Publications (1)

Publication Number Publication Date
US3623475A true US3623475A (en) 1971-11-30

Family

ID=46705089

Family Applications (1)

Application Number Title Priority Date Filing Date
US843096A Expired - Lifetime US3623475A (en) 1968-07-26 1969-07-18 Blood collector device

Country Status (2)

Country Link
US (1) US3623475A (en)
CH (1) CH522395A (en)

Cited By (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3943917A (en) * 1972-11-06 1976-03-16 Radiometer A/S Method for collecting blood samples
DE2558311A1 (en) * 1974-12-23 1976-07-01 Becton Dickinson Co Micro blood collection device
US4091802A (en) * 1976-02-17 1978-05-30 Eastman Kodak Company Vented liquid collection device
US4136036A (en) * 1976-04-07 1979-01-23 Eastman Kodak Company Collection and dispensing device for non-pressurized liquids
US4215700A (en) * 1978-08-25 1980-08-05 Sherwood Medical Industries Inc. Blood collection device
US4314570A (en) * 1977-11-18 1982-02-09 Sarstedt W Capillary receptacle
US4576185A (en) * 1983-12-05 1986-03-18 Terumo Medical Corporation Collection device for capillary blood
EP0189118A2 (en) * 1985-01-25 1986-07-30 Becton, Dickinson and Company Blood collection assembly
US4615341A (en) * 1981-06-18 1986-10-07 Syringe Industries, Inc. Syringe device for physiological fluid sampling
US4669486A (en) * 1984-01-20 1987-06-02 Anders Trell Device for taking and dispensing blood samples for the purpose of determining blood sedimentation
US5026388A (en) * 1989-09-26 1991-06-25 Ingalz Thomas J Single-use skin puncture device
US5387203A (en) * 1993-06-28 1995-02-07 Goodrich; Hubert J. Subcutaneous extractor
US5891053A (en) * 1995-05-25 1999-04-06 Kabushiki Kaisya Advance Blood-collecting device
US6193675B1 (en) 1996-05-30 2001-02-27 Teva Medical Ltd Fluid sampling apparatus
US6219574B1 (en) * 1996-06-18 2001-04-17 Alza Corporation Device and method for enchancing transdermal sampling
US6261270B1 (en) * 1998-09-23 2001-07-17 Abbott Laboratories Sleeve stopper
US6468229B1 (en) 1998-10-20 2002-10-22 Abbott Laboratories Apparatus and method for the collection of interstitial fluids
US6706000B2 (en) 1997-11-21 2004-03-16 Amira Medical Methods and apparatus for expressing body fluid from an incision
US20040122339A1 (en) * 2002-12-24 2004-06-24 Roe Steven N. Sampling devices and methods utilizing biased capillary action
US20040171968A1 (en) * 2001-07-13 2004-09-02 Koji Katsuki Analyzing apparatus, piercing element integrally installed body for temperature measuring device with analyzing apparatus, and body fluid sampling apparatus
US20050215925A1 (en) * 2004-03-25 2005-09-29 Chan Frank A Pulsating expression cap
US20050277972A1 (en) * 2004-06-10 2005-12-15 Daniel Wong Expression pad
US20060052723A1 (en) * 2004-09-09 2006-03-09 Roe Steven N Device for sampling bodily fluids
US20060052724A1 (en) * 2004-09-09 2006-03-09 Roe Steven N Device for sampling bodily fluids
US7235056B2 (en) 1996-05-17 2007-06-26 Amira Medical Body fluid sampling device and methods of use
US7247144B2 (en) 1996-05-17 2007-07-24 Roche Diagnostics Operations, Inc. Methods and apparatus for sampling and analyzing body fluid
WO2007041062A3 (en) * 2005-09-30 2007-12-13 Rosedale Medical Inc Devices and methods for facilitating fluid transport
US20090204086A1 (en) * 2006-09-15 2009-08-13 Robert Kizer Cerebrospinal fluid collection tubes and methods
US7758516B2 (en) 2001-09-26 2010-07-20 Roche Diagnostics Operations, Inc. Method and apparatus for sampling bodily fluid
US7758518B2 (en) 2001-06-08 2010-07-20 Roche Diagnostics Operations, Inc. Devices and methods for expression of bodily fluids from an incision
US7828749B2 (en) 1996-05-17 2010-11-09 Roche Diagnostics Operations, Inc. Blood and interstitial fluid sampling device
US7841991B2 (en) 1996-05-17 2010-11-30 Roche Diagnostics Operations, Inc. Methods and apparatus for expressing body fluid from an incision
US8231832B2 (en) 2003-03-24 2012-07-31 Intuity Medical, Inc. Analyte concentration detection devices and methods
US8360994B2 (en) 2005-09-30 2013-01-29 Intuity Medical, Inc. Arrangement for body fluid sample extraction
CN104127190A (en) * 2013-05-03 2014-11-05 品强科技精密有限公司 Blood sampling device allowing controllable puncturing depth
US8919605B2 (en) 2009-11-30 2014-12-30 Intuity Medical, Inc. Calibration material delivery devices and methods
US8969097B2 (en) 2005-06-13 2015-03-03 Intuity Medical, Inc. Analyte detection devices and methods with hematocrit-volume correction and feedback control
US20150351676A1 (en) * 2014-06-10 2015-12-10 Labatm, Inc. Automatic Blood Collection
WO2016010817A1 (en) * 2014-07-18 2016-01-21 Becton, Dickinson And Company Lancet device with first-drop removal
US9636051B2 (en) 2008-06-06 2017-05-02 Intuity Medical, Inc. Detection meter and mode of operation
CN106999120A (en) * 2014-08-01 2017-08-01 塔索公司 Devices, systems and methods for gravity-enhanced microfluidic collection, handling and transferring of fluids
US9782114B2 (en) 2011-08-03 2017-10-10 Intuity Medical, Inc. Devices and methods for body fluid sampling and analysis
US9833183B2 (en) 2008-05-30 2017-12-05 Intuity Medical, Inc. Body fluid sampling device—sampling site interface
US9956555B2 (en) 2012-11-30 2018-05-01 Rarecyte, Inc. Apparatus, system, and method for collecting a target material

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT84897B (en) * 1920-01-21 1921-07-25 Elemer Lukacs Device for administration of fluids.
GB412124A (en) * 1932-12-23 1934-06-21 Yasujiro Okumura Improvements in devices for puncturing the skin
FR771890A (en) * 1933-04-24 1934-10-18 Improvements to devices for taking blood to the hollow with a needle biased by a spring
US3063451A (en) * 1959-09-28 1962-11-13 Arthur J Kowalk Self-venting type needle
US3134380A (en) * 1962-02-08 1964-05-26 Thomas A Armao Shielded hypodermic needle
US3322121A (en) * 1965-11-26 1967-05-30 Oscar H Banker Skin-puncturing unit with a collapsible protective cover
GB1080986A (en) * 1964-09-02 1967-08-31 Allen And Hanburys Surgical En Multiple puncture apparatus
US3369708A (en) * 1965-09-07 1968-02-20 Lincoln Lab Inc Means for reconstituting a dry biological and for controlled dispensing thereof
US3433216A (en) * 1966-12-22 1969-03-18 Roger P Mattson Self-evacuating fluid sampling device

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT84897B (en) * 1920-01-21 1921-07-25 Elemer Lukacs Device for administration of fluids.
GB412124A (en) * 1932-12-23 1934-06-21 Yasujiro Okumura Improvements in devices for puncturing the skin
FR771890A (en) * 1933-04-24 1934-10-18 Improvements to devices for taking blood to the hollow with a needle biased by a spring
US3063451A (en) * 1959-09-28 1962-11-13 Arthur J Kowalk Self-venting type needle
US3134380A (en) * 1962-02-08 1964-05-26 Thomas A Armao Shielded hypodermic needle
GB1080986A (en) * 1964-09-02 1967-08-31 Allen And Hanburys Surgical En Multiple puncture apparatus
US3369708A (en) * 1965-09-07 1968-02-20 Lincoln Lab Inc Means for reconstituting a dry biological and for controlled dispensing thereof
US3322121A (en) * 1965-11-26 1967-05-30 Oscar H Banker Skin-puncturing unit with a collapsible protective cover
US3433216A (en) * 1966-12-22 1969-03-18 Roger P Mattson Self-evacuating fluid sampling device

Cited By (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3943917A (en) * 1972-11-06 1976-03-16 Radiometer A/S Method for collecting blood samples
DE2558311A1 (en) * 1974-12-23 1976-07-01 Becton Dickinson Co Micro blood collection device
US4024857A (en) * 1974-12-23 1977-05-24 Becton, Dickinson And Company Micro blood collection device
US4091802A (en) * 1976-02-17 1978-05-30 Eastman Kodak Company Vented liquid collection device
US4136036A (en) * 1976-04-07 1979-01-23 Eastman Kodak Company Collection and dispensing device for non-pressurized liquids
US4314570A (en) * 1977-11-18 1982-02-09 Sarstedt W Capillary receptacle
US4215700A (en) * 1978-08-25 1980-08-05 Sherwood Medical Industries Inc. Blood collection device
US4615341A (en) * 1981-06-18 1986-10-07 Syringe Industries, Inc. Syringe device for physiological fluid sampling
US4576185A (en) * 1983-12-05 1986-03-18 Terumo Medical Corporation Collection device for capillary blood
US4669486A (en) * 1984-01-20 1987-06-02 Anders Trell Device for taking and dispensing blood samples for the purpose of determining blood sedimentation
EP0189118A2 (en) * 1985-01-25 1986-07-30 Becton, Dickinson and Company Blood collection assembly
EP0189118A3 (en) * 1985-01-25 1989-05-10 Becton, Dickinson And Company Blood collection assembly
US5026388A (en) * 1989-09-26 1991-06-25 Ingalz Thomas J Single-use skin puncture device
US5387203A (en) * 1993-06-28 1995-02-07 Goodrich; Hubert J. Subcutaneous extractor
US5891053A (en) * 1995-05-25 1999-04-06 Kabushiki Kaisya Advance Blood-collecting device
US8690798B2 (en) 1996-05-17 2014-04-08 Roche Diagnostics Operations, Inc. Methods and apparatus for sampling and analyzing body fluid
US7828749B2 (en) 1996-05-17 2010-11-09 Roche Diagnostics Operations, Inc. Blood and interstitial fluid sampling device
US7727168B2 (en) 1996-05-17 2010-06-01 Roche Diagnostics Operations, Inc. Methods and apparatus for sampling and analyzing body fluid
US20110046515A1 (en) * 1996-05-17 2011-02-24 Douglas Joel S Methods and apparatus for expressing body fluid from an incision
US7901363B2 (en) 1996-05-17 2011-03-08 Roche Diagnostics Operations, Inc. Body fluid sampling device and methods of use
US7247144B2 (en) 1996-05-17 2007-07-24 Roche Diagnostics Operations, Inc. Methods and apparatus for sampling and analyzing body fluid
US8123701B2 (en) 1996-05-17 2012-02-28 Roche Diagnostics Operations, Inc. Methods and apparatus for sampling and analyzing body fluid
US7731668B2 (en) 1996-05-17 2010-06-08 Roche Diagnostics Operations, Inc. Methods and apparatus for sampling and analyzing body fluid
US7235056B2 (en) 1996-05-17 2007-06-26 Amira Medical Body fluid sampling device and methods of use
US8231549B2 (en) 1996-05-17 2012-07-31 Roche Diagnostics Operations, Inc. Methods and apparatus for sampling and analyzing body fluid
US8740813B2 (en) 1996-05-17 2014-06-03 Roche Diagnostics Operations, Inc. Methods and apparatus for expressing body fluid from an incision
US7841991B2 (en) 1996-05-17 2010-11-30 Roche Diagnostics Operations, Inc. Methods and apparatus for expressing body fluid from an incision
US6193675B1 (en) 1996-05-30 2001-02-27 Teva Medical Ltd Fluid sampling apparatus
US20070118070A1 (en) * 1996-06-18 2007-05-24 Cormier Michel J Device with anchoring elements for transdermal delivery or sampling of agents
US6219574B1 (en) * 1996-06-18 2001-04-17 Alza Corporation Device and method for enchancing transdermal sampling
US6706000B2 (en) 1997-11-21 2004-03-16 Amira Medical Methods and apparatus for expressing body fluid from an incision
US20060155316A1 (en) * 1997-11-21 2006-07-13 Roche Diagnostics Operations, Inc. Methods and apparatus for expressing body fluid from an incision
US6261270B1 (en) * 1998-09-23 2001-07-17 Abbott Laboratories Sleeve stopper
US6468229B1 (en) 1998-10-20 2002-10-22 Abbott Laboratories Apparatus and method for the collection of interstitial fluids
US6786874B2 (en) 2001-01-26 2004-09-07 Abbott Laboratories Apparatus and method for the collection of interstitial fluids
US9538941B2 (en) 2001-06-08 2017-01-10 Roche Diabetes Care, Inc. Devices and methods for expression of bodily fluids from an incision
US7758518B2 (en) 2001-06-08 2010-07-20 Roche Diagnostics Operations, Inc. Devices and methods for expression of bodily fluids from an incision
US20040171968A1 (en) * 2001-07-13 2004-09-02 Koji Katsuki Analyzing apparatus, piercing element integrally installed body for temperature measuring device with analyzing apparatus, and body fluid sampling apparatus
US7879211B2 (en) * 2001-07-13 2011-02-01 Arkray, Inc. Analyzing instrument, lancet-integrated attachment for concentration measuring device provided with analyzing instrument, and body fluid sampling tool
US7758516B2 (en) 2001-09-26 2010-07-20 Roche Diagnostics Operations, Inc. Method and apparatus for sampling bodily fluid
US8083688B2 (en) 2002-12-24 2011-12-27 Roche Diagnostics Operations, Inc. Sampling devices and methods utilizing biased capillary action
US20040122339A1 (en) * 2002-12-24 2004-06-24 Roe Steven N. Sampling devices and methods utilizing biased capillary action
US20100145228A1 (en) * 2002-12-24 2010-06-10 Roe Steven N Sampling devices and methods utilizing biased capillary action
US9095292B2 (en) 2003-03-24 2015-08-04 Intuity Medical, Inc. Analyte concentration detection devices and methods
US8231832B2 (en) 2003-03-24 2012-07-31 Intuity Medical, Inc. Analyte concentration detection devices and methods
US20070156065A1 (en) * 2004-03-25 2007-07-05 Chan Frank A Pulsating expression cap
US20050215925A1 (en) * 2004-03-25 2005-09-29 Chan Frank A Pulsating expression cap
US20090124930A1 (en) * 2004-03-25 2009-05-14 Chan Frank A Pulsating expression cap
US7201723B2 (en) 2004-03-25 2007-04-10 Roche Diagnostics Operations, Inc. Pulsating expression cap
US9332931B2 (en) 2004-03-25 2016-05-10 Roche Diabetes Care, Inc. Pulsating expression cap
US20050277972A1 (en) * 2004-06-10 2005-12-15 Daniel Wong Expression pad
US7384402B2 (en) 2004-06-10 2008-06-10 Roche Diagnostics Operations, Inc. Expression pad
US7604604B2 (en) 2004-09-09 2009-10-20 Roche Diagnostics Operations, Inc. Device for sampling bodily fluids
US8419657B2 (en) 2004-09-09 2013-04-16 Roche Diagnostics Operations, Inc. Device for sampling bodily fluids
US7645241B2 (en) 2004-09-09 2010-01-12 Roche Diagnostics Operations, Inc. Device for sampling bodily fluids
US20060052723A1 (en) * 2004-09-09 2006-03-09 Roe Steven N Device for sampling bodily fluids
US20060052724A1 (en) * 2004-09-09 2006-03-09 Roe Steven N Device for sampling bodily fluids
US20100069793A1 (en) * 2004-09-09 2010-03-18 Roe Steven N Device for sampling bodily fluids
US9366636B2 (en) 2005-06-13 2016-06-14 Intuity Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
US10226208B2 (en) 2005-06-13 2019-03-12 Intuity Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
US8969097B2 (en) 2005-06-13 2015-03-03 Intuity Medical, Inc. Analyte detection devices and methods with hematocrit-volume correction and feedback control
US8360993B2 (en) 2005-09-30 2013-01-29 Intuity Medical, Inc. Method for body fluid sample extraction
US8360994B2 (en) 2005-09-30 2013-01-29 Intuity Medical, Inc. Arrangement for body fluid sample extraction
US8801631B2 (en) * 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
US9839384B2 (en) 2005-09-30 2017-12-12 Intuity Medical, Inc. Body fluid sampling arrangements
WO2007041062A3 (en) * 2005-09-30 2007-12-13 Rosedale Medical Inc Devices and methods for facilitating fluid transport
US9060723B2 (en) 2005-09-30 2015-06-23 Intuity Medical, Inc. Body fluid sampling arrangements
US8795201B2 (en) 2005-09-30 2014-08-05 Intuity Medical, Inc. Catalysts for body fluid sample extraction
US9380974B2 (en) 2005-09-30 2016-07-05 Intuity Medical, Inc. Multi-site body fluid sampling and analysis cartridge
US8382681B2 (en) 2005-09-30 2013-02-26 Intuity Medical, Inc. Fully integrated wearable or handheld monitor
US8231586B2 (en) * 2006-09-15 2012-07-31 Creighton University Cerebrospinal fluid collection tubes and methods
US20090204086A1 (en) * 2006-09-15 2009-08-13 Robert Kizer Cerebrospinal fluid collection tubes and methods
US9833183B2 (en) 2008-05-30 2017-12-05 Intuity Medical, Inc. Body fluid sampling device—sampling site interface
US9636051B2 (en) 2008-06-06 2017-05-02 Intuity Medical, Inc. Detection meter and mode of operation
US8919605B2 (en) 2009-11-30 2014-12-30 Intuity Medical, Inc. Calibration material delivery devices and methods
US9897610B2 (en) 2009-11-30 2018-02-20 Intuity Medical, Inc. Calibration material delivery devices and methods
US9782114B2 (en) 2011-08-03 2017-10-10 Intuity Medical, Inc. Devices and methods for body fluid sampling and analysis
US9956555B2 (en) 2012-11-30 2018-05-01 Rarecyte, Inc. Apparatus, system, and method for collecting a target material
CN104127190A (en) * 2013-05-03 2014-11-05 品强科技精密有限公司 Blood sampling device allowing controllable puncturing depth
US20150351676A1 (en) * 2014-06-10 2015-12-10 Labatm, Inc. Automatic Blood Collection
US9743876B2 (en) 2014-07-18 2017-08-29 Becton, Dickinson And Company Lancet device with first-drop removal
AU2015290049B2 (en) * 2014-07-18 2018-09-06 Becton, Dickinson And Company Lancet device with first-drop removal
CN106687040A (en) * 2014-07-18 2017-05-17 贝克顿·迪金森公司 Lancet device with first-drop removal
WO2016010817A1 (en) * 2014-07-18 2016-01-21 Becton, Dickinson And Company Lancet device with first-drop removal
EP3174463A4 (en) * 2014-08-01 2018-01-24 Tasso, Inc. Devices, systems and methods for gravity-enhanced microfluidic collection, handling and transferring of fluids
CN106999120A (en) * 2014-08-01 2017-08-01 塔索公司 Devices, systems and methods for gravity-enhanced microfluidic collection, handling and transferring of fluids

Also Published As

Publication number Publication date
CH522395A (en) 1972-05-15

Similar Documents

Publication Publication Date Title
US6093156A (en) Method and apparatus for obtaining blood for diagnostic tests
US7476202B2 (en) Sampling devices and methods utilizing a horizontal capillary test strip
RU2343833C2 (en) Integral sample gauge
US8986222B2 (en) Biopsy apparatus
AU2006235249B2 (en) Finger activated lancet device
US6099484A (en) Methods and apparatus for sampling and analyzing body fluid
US6660018B2 (en) Multiple lancet device
ES2359492T3 (en) System for withdrawing a body fluid, in particular blood.
RU2114559C1 (en) One-time puncturing device
US5964718A (en) Body fluid sampling device
US6352514B1 (en) Methods and apparatus for sampling and analyzing body fluid
US4776346A (en) Biopsy instrument
JP3993529B2 (en) Blood collection system
US4442836A (en) Blood lancet device
US5190556A (en) Cord cutter sampler
EP0544837B1 (en) Disposable skin perforator and blood testing device
ES2329675T5 (en) Cap device for dermal tissue lancing
EP0931507B1 (en) Body-fluid inspection device
US5776058A (en) Pressure-attached presenting part fetal pulse oximetry sensor
US3889657A (en) Uterine aspirating curette
EP1586269A1 (en) A cap for a dermal tissue lancing device
US6071294A (en) Lancet cartridge for sampling blood
ES2272588T3 (en) Split pressure ring for a lancing device and blood collection system.
JP3393920B2 (en) Small amount of constant volume blood collection point garment
US6866675B2 (en) Lancet device having capillary action

Legal Events

Date Code Title Description
AS Assignment

Owner name: ROHM & HAAS COMPANY (MERGED WITH AND INTO)

Free format text: RE-RECORD OF AN INSTRUMENT RECORDED OCT. 6, 1980, REEL 3804, FRAMES 837-840, TO SHOW NEW OWNER OF SAID PATENTS;ASSIGNOR:MICROMEDIC SYSTEMS, INC.;REEL/FRAME:003848/0449

Effective date: 19800903

Owner name: ROHM & HAAS COMPANY (MERGED WITH AND INTO),PENNSYL

Free format text: RE-RECORD OF AN INSTRUMENT RECORDED OCT. 6, 1980, REEL 3804, FRAMES 837-840, TO SHOW NEW OWNER OF SAID PATENTS;ASSIGNOR:MICROMEDIC SYSTEMS, INC.;REEL/FRAME:3848/449

Owner name: ROHM & HAAS COMPANY (MERGED WITH AND INTO), PENNSY

AS Assignment

Owner name: ICN MICROMEDIC SYSTEMS, INC., 3300 HYLAND AVENUE,

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:MICROMEDIC SYSTEMS, INC., A CORP OF DE.;REEL/FRAME:004488/0488

Effective date: 19851121