Connect public, paid and private patent data with Google Patents Public Datasets

Method for filling a syringe

Download PDF

Info

Publication number
US3578037A
US3578037A US3578037DA US3578037A US 3578037 A US3578037 A US 3578037A US 3578037D A US3578037D A US 3578037DA US 3578037 A US3578037 A US 3578037A
Authority
US
Grant status
Grant
Patent type
Prior art keywords
container
syringe
material
stopper
needle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
Thomas J Flynn
Original Assignee
Thomas J Flynn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096Combination of a vial and a syringe for transferring or mixing their contents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/201Piercing means having one piercing end
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079Filtering means
    • A61J1/2086Filtering means for fluid filtration

Abstract

An apparatus and method for preventing foreign material from entering syringes during the filling of the syringes from containers and thus preventing foreign material from being injected into a patient. The apparatus provides a liquid container, such as a vial, having a pierceable self-sealing stopper for inserting the syringe needle for filling the syringe. A filter material is attached to the top of the container so that the needle can be extended therethrough and adapted to filter out foreign material such as coring that breaks loose as the needle pierces the top of the container. A method is provided including drawing air into a syringe prior to inserting the syringe cannula through a pierceable self-sealing stopper of a container. The air in the syringe is then injected into the container freeing any coring material that has broken from the container stopper either into the filtering material or into the liquid in the container. The cannula tip is then withdrawn or extended to place the tip either in the liquid or the filter material where the coring material has not been deposited and drawing the required amount of liquid from the container into the syringe.

Description

United States Patent [72] lnventor Thomas J. Flynn 112 White Cap Ave.. Daytona Beach, Fla. 32018 [21 1 Appl. No. 857,089

[22] Filed Sept. 11,1969

[45] Patented May 11, 1971 [54] METHOD FOR FILLING A SYRINGE l28/(lnquired), 218 (M), 272; 141/1, 2, 3, 18-29, 286, 329, 330; 220/(lnquired);

222/(lnquired) [56] ReferencesCited UNITED STATES PATENTS 1,178,512 4/1916 Garlock 141/23 Pn'mary Examiner-Houston S. Bell, Jr. Attorney-Duckworth & Hobby ABSTRACT: An apparatus and method for preventing foreign material from entering syringes during the filling of the syringes from containers and thus preventing foreign material from being injected into a patient. The apparatus provides a liquid container, such as a vial, having a pierceable self-sealing stopper for inserting the syringe needle for filling the syringe. A filter material is attached to the top of the container so that the needle can be extended therethrough and adapted to filter out foreign material such as coring that breaks loose as the needle pierces the top of the container. A method is provided including drawing air into a syringe prior to inserting the syringe cannula through a pierceable self-sealing stopper of a container. The air in'the syringe is then injected into the container freeing any coring material that has broken from the container stopper either into the filtering material or into the liquid in the container. The cannula tip is then withdrawn or extended to place the tip either in the liquid or the filter material where the coring material has not been deposited and drawing the required amount of liquid from the container into the syringe.

PATENTEU'HAYHIHYI H 3,578,037

INV NTOR.

METHOD FOR FILLING A SYRINGE BACKGROUND OF THE INVENTION I. Field of the Invention The present invention relates to containers, vials and other bottles, and the like, having pierceable self-sealing-type stoppers or tops adapted for easy filling of syringes by inserting the needles through the stoppers into the containers and more particularly to the method and apparatus utilized in filling syringes in a manner to prevent coring material or fine pieces of the stopper for the containers from entering the syringes and being injected into the patients. Coring" is a term used in the medical profession to indicate small pieces of rubber that are cut or broken loose when the needle or cannula of a syringe is pushed through the rubber stopper on the top of a container. This piece of rubber or core is usually forced into the liquid in the container or vial and then may enter the syringe along with the liquid when the syringe is filled. Thus a small core can be pulled into the syringe and injected into the patient, especially in the case of multiple-dose vials or containers where many penetrations of the rubber stopper are expected. The problem of coring has plagued the industry for many years and has resulted in many suggestions to remedy the problem.

2. Description of the Prior Art In the past, a number of suggestions have been made for remedying the coring problem and also for filtering liquids. These prior art approaches include primarily studies of the type of material used for the stopper to find a material that is less likely to provide a coring action, aswell as a study of the thickness and shape of the stopper in order to provide a combination of ingredients in the stopper to reduce the amount of coring and the amount of foreign materials that can get into a vial. It has also been suggested in the pastto use various types of pressure to force the stopper into the vial to reduce the coring as well as to change the shape of the needle tip cutting edge of the needle to reduce the coring action. While these various approaches have improved and reduced the coring problem, they have not to date been successful in eliminating it and there apparently has been only one successful way that a core-free injection can be obtained prior to my invention. This is performed by using a very costly filtered needle for injection into the patient but the increased cost of this'needle makes it uneconomical, especially in view of the trend toward using disposable syringes and needles, which disposable syringes are not only convenient but provide a solution to the sterilization problem, especially as relates to viruses such as hepatitis that may be transmitted by reusable needles.

It has also been suggested in the past to provide various types of combinations or syringes and vials which are either disposable or may be reloaded and maintained as a combination vial, syringe and needle. Thus a physician who has to carry a hypodermic syringe along with the injection material, antiseptic and absorbent material with him for a specific injection, can have the syringe and injection liquid and container combination put together in a manner as not to damage the needle in transit and sometimes even to incorporate absorbent material and antiseptic in a combination unit.

It has also been suggested to have stoppered tops with absorbent material in a chamber therein, which chamber is adapted to allow sterilized air to enter into the container to replace the space from the removal of part of the liquid into the syringe.

Finally, one prior art US. Pat. No. 2,585,938, has suggested a bottle seal having a filter in the bottle or container in which sterile blood is kept for use in blood transfusions. This prior art filter is in the form of a hollow tube inside of a container with an open mouth sealed against the inner surface of a stopper, with indicia on the outer surface of the stopper to indicate the location for inserting the needle so'that it will enter into the hollow space in the filter. While this prior art filter is desirable for use with transfusions of blood to remove clotting material, and the like, it would of course not be satisfactory for filtering coring material since the liquid is withdrawn from the same hollow chamber in which it had been inserted leaving the coring material in a position to be even more likely to be transferred to the patient.

Accordingly, it is an object of my invention to provide an economical, anticoring device and method from which foreign matter and coring material may be prevented from being injected into a patient in a very inexpensive manner even when used with the multiple-dose vials while allowing disposable syringes and needles to be utilized in giving injections.

SUMMARY OF THE INVENTION An apparatus and method are provided for preventing foreign particles such as coring material from being accidentally injected into a patient. A liquid container or vial is provided having a pierceable self-sealing stopper adapted for piercing with a needle or cannula of a syringe during filling of the syringe prior to giving an injection to a patient. The selfsealing stopper has a filter fixedly attached to the stopper and inside the liquid container and extending into the container whereby a syringe needle when inserted through the self'sealing stopper may be extended through the filter into a liquid for filling, or ,may be retracted into the filter for filling with the liquid in a container. A method for filling a syringe is provided which includes the steps of drawing air into the syringe in the approximate amount of the liquid to be withdrawn into the syringe then inserting the cannula of the syringe through a pierceable, self-sealing stopper or top of a liquid-containing container, injecting the air from the syringe into the container thereby expelling any coring material or foreign matter that may have gotten into the syringe needle either into the mass of a filter material or,directly into one or the other side of the filter material thereby isolating the foreign material either in the filter or to one side or the other of the filter. The needle tip is positioned into the filter material or to either side thereof but otherwise than where the foreign matter has been expelled from the syringe needle or broken off from the rubber stopper and finally drawing liquid in the container into the syringe in a position isolated from the foreign matter expelled or broken off.

BRIEF DESCRIPTION OF THE DRAWING Other objects, features and advantages of this invention will be apparent from a study of the written description and the drawings in which:

FIG. 1 shows a sectional view of one embodiment of the present invention;

FIG. 2 shows a view taken along line 2-2 of FIG. 1; and

FIG. 3 shows an exploded view of the top portion of the container of FIGS. 1 and 2.

DESCRIPTION OF THE PREFERRED EMBODIMENTS Referring now to FIG. 1, there can be seen a liquid container or vial 10 held in a mans hand 11 and having a stopper cover or seal 12 for holding the stopper 13 within the container I0. Stopper 13 maintains a liquid 14 within the container 10 in a manner to prevent the liquid from leaking out and also to prevent ingress into the container of contaminations. Container 10 would typically be a glass container while stopper 13 would be a special rubber or synthetic resilient material especially adapted for use as stoppers for vials that hold medicine and sealing member 12 could typically be a metallic seal such as aluminum. A hypodermic syringe I5can be seen having a needle or cannula 16 extending therefrom and through the rubber stopper 13 into the liquid container I0. The needle 10 has a portion 17 which typically has a cutting edge so that it may easily pierce the stopper 13 in container I0 and also easily pierce the skin and flesh of a patient .being injected with the syringe l5. Syringe I5 is shown being held by hand 9 pushing a finger plate or handle 18 which is adapted to operate a piston or plunger 19 for filling the syringe or injecting the liquid in the syringe into a patient. Container 10 stopper 13 can be seen to have a filter 20, such as may be a foamed plastic material, which is especially adapted for filtering out small particles of foreign matter that may enter into the container 10. Filter 20 can be seen to be connected to stopper 13 and extending into container 10 a short distance relative to the larger tubular length of container 10. in a typical operation for injecting a patient, the syringe 15 might be filled with air in approximately the same volume as the liquid injection medicine 14 that is to be injected into the patient. The syringe is inserted through rubber stopper 13 which is a self-sealing pierceable stopper and into container 10. The air in syringe 15 is injected into the container 10 and the desired amount of liquid 14 withdrawn into syringe 15 for injection into a patient. The syringe needle would then be withdrawn from the container and injected into the patient. However, one of the problems experienced in this operation is that small pieces of stopper 13 break off inside the container when the needle 16 is inserted therethrough, resulting in small bits of foreign matter entering the liquid 14 which may then be drawn into the syringe l and injected into a patient accidentally. In addition to coring material other foreign matter may also accidentally get into the container 10. This problem is especially troublesome in multiple injection vials in which small pieces of coring material may accumulate and increase the probability of accidentally getting a piece of material in the needle 16 or syringe 15 and injecting the material into the patient. It is ac cordingly desirable to have a stopper 13 made of a material that is both inert to the medicine 14 while having desirable anticoring characteristics.

Turning now to FIG. 2, there can be seen a view taken along line 2-2 of FIG. 1 showing a portion of container having a liquid 14 therein maintained in the container 10 by stopper 13 which has a sealing member 12 for assuring that the stopper 13 is not removed and is held tightly in place in the container 10. A portion 21 of stopper 13 can be seen to be not covered by the winding 12 so that needle 16 can be easily pierced through stopper 13 for withdrawing liquid 14 into the syringe. An arcuate portion 26 of the stopper 13 provides the stopper with desirable anticoring characteristics while leaving a space 22 located within the general confines of the stopper 13. Filter material 20 is illustrated as an inorganic flexible cellular material such as a foamed resilient polyurethane plastic which must be desirably inert to the liquid 14 while acting as a filter to filter out or hold foreign particles such as coring material. Filter 20 is held to stopper 13 by a heat seal at surface 23 connecting the rim 24 of stopper 13 to filter 20 thus leaving the space 22 totally enclosed on one side of the filter 20.

With reference to FIGS. 1 and 2, the following embodi' ments of my method for filling a syringe are provided. The syringe may be filled with air or other gas as desired in approximately the same volume as liquid 14 that is to be withdrawn from container 10 for injection into a patient. The needle portion 16 of the syringe 15 is then inserted through stopper 13 into container 10 where it could pick up a piece of coring material in the cutting end 17 of the needle 16 or the coring material could break off directly into space 22. Needle 16 could be extended past filter and the air injected into the container 10 which would inject any foreign material therein into the liquid 14. The tip 17 of needle 16 could then be withdrawn into filter 20 prior to the step of withdrawing the desired amount of the medicine 14 froma zone isolated from that of where the coring material was injected or broke off in container 10 whereby the syringe 15 is filled substantially free of foreign matter or coring material. Alternatively, the needle tip 17 could originally be inserted into the area 22 or into filter 20 and in these zones inject the air from syringe 15 into container 10 thus trapping any foreign particles or coring material either in the isolated portion 22 or within the filter material 20 then pushing the tip 17 of needle 16 further into container 10 into the open area of liquid 14 and filling any desired amount whereby foreign matter is again isolated from the needle tip 17 and from entering into the syringe 15 thus protecting patients from havin foreign materials injected into them.

FIG. 3 s ows an exploded view with the top or lip of bottle 25 or bottle 10 being visible with the stopper 13 being removed therefrom along with the sealing member 12 which desirably is wrapped around stopper 13 top and around lip 25 of container 10 when the container is filled. The filtering material 20 can be seen heat sealed to stopper 13 at 23. It will of course be clear that material 20 can be varied as well as can be the means for connecting material 20 to the stopper 13 without departing from the spirit and scope of the invention. The filter 20 by preventing coring materials from entering the bottle may allow top 13 arcuate portion 26 to be changed.

It will of course be clear that an anticoring method and apparatus have been provided for the inexpensive prevention of foreign materials from being injected into patients but this invention is not to be construed as limited to the particular forms disclosed herein since these are to be regarded as illustrative rather than restrictive.

lclaim:

1. A method for filling a syringe from a container of liquid comprising in combination the steps of:

a. drawing gas into said syringe;

b. inserting the needle of said syringe through a pierceable self-sealing stopper located in an opening to said container;

c. injecting gas in said syringe into said container thereby expelling any foreign material from said needle in one area of said container;

d. locating the tip of said needle in a second area of said container separated from said one area by a filtering material; and

e. drawing liquid from said container into said syringe.

2. The method according to claim 1 in which said locating said needle tip in one area includes locating said needle tip within a filter material.

3. The method according to claim 1 in which said locating said needle tip in one area includes locating said needle tip to one side of a filter material.

4. The method according to claim 1 in which said gas drawn into said syringe is air having a volume in approximately the same volume of liquid that is to be drawn from said container into said syringe.

Claims (4)

1. A method for filling a syringe from a container of liquid comprising in combination the steps of: a. drawing gas into said syringe; b. inserting the needle of said syringe through a pierceable self-sealing stopper located in an opening to said container; c. injecting gas in said syringe into said container thereby expelling any foreign material from said needle in one area of said container; d. locating the tip of said needle in a second area of said container separated from said one area by a filtering material; and e. drawing liquid from said containEr into said syringe.
2. The method according to claim 1 in which said locating said needle tip in one area includes locating said needle tip within a filter material.
3. The method according to claim 1 in which said locating said needle tip in one area includes locating said needle tip to one side of a filter material.
4. The method according to claim 1 in which said gas drawn into said syringe is air having a volume in approximately the same volume of liquid that is to be drawn from said container into said syringe.
US3578037A 1969-09-11 1969-09-11 Method for filling a syringe Expired - Lifetime US3578037A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US85708969 true 1969-09-11 1969-09-11

Publications (1)

Publication Number Publication Date
US3578037A true US3578037A (en) 1971-05-11

Family

ID=25325156

Family Applications (1)

Application Number Title Priority Date Filing Date
US3578037A Expired - Lifetime US3578037A (en) 1969-09-11 1969-09-11 Method for filling a syringe

Country Status (1)

Country Link
US (1) US3578037A (en)

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3770026A (en) * 1971-09-17 1973-11-06 J Isenberg Apparatus and method for accurately loading syringes
US3788369A (en) * 1971-06-02 1974-01-29 Upjohn Co Apparatus for transferring liquid between a container and a flexible bag
US4046145A (en) * 1976-06-29 1977-09-06 American Hospital Supply Corporation Syringe connector
US4121735A (en) * 1974-09-19 1978-10-24 Goldwell Gmbh, Chemische Fabrik H.E.Dotter System for quantity-controlled spraying of a liquid active ingredient
US4316941A (en) * 1979-10-02 1982-02-23 Asahi Glass Company Ltd. Rubber stopper for sealing
US4321306A (en) * 1978-11-17 1982-03-23 Tsukasa Eguchi Rubber stopper for tight sealing
US4410321A (en) * 1982-04-06 1983-10-18 Baxter Travenol Laboratories, Inc. Closed drug delivery system
US4411662A (en) * 1982-04-06 1983-10-25 Baxter Travenol Laboratories, Inc. Sterile coupling
US4484920A (en) * 1982-04-06 1984-11-27 Baxter Travenol Laboratories, Inc. Container for mixing a liquid and a solid
US4489766A (en) * 1982-09-13 1984-12-25 Montada Benjamin V Syringe filling device
US4493348A (en) * 1981-06-29 1985-01-15 Pur/Acc Corporation Method and apparatus for orally dispensing liquid medication
US4573994A (en) * 1979-04-27 1986-03-04 The Johns Hopkins University Refillable medication infusion apparatus
US4582207A (en) * 1985-04-02 1986-04-15 Bristol-Myers Company Safety reservoir snap on overcap for parenteral drug container
US4666427A (en) * 1984-12-27 1987-05-19 Viggo Ab Fluid and particle absorbing body for apertures in injection instruments
US4756974A (en) * 1986-11-10 1988-07-12 The West Company Incorporated Elastomeric component for pharmaceutical devices
US4850137A (en) * 1984-06-25 1989-07-25 Foster Charles W Device for watering and removing water from cut plant containers
US5035689A (en) * 1989-03-13 1991-07-30 Schroeder Thomas J Luer-loc-tipped vial--syringe combination
US5088996A (en) * 1984-04-16 1992-02-18 Kopfer Rudolph J Anti-aerosoling drug reconstitution device
US5409125A (en) * 1989-12-11 1995-04-25 Aktiebolaget Astra Unit dose container
US20010039058A1 (en) * 1999-05-14 2001-11-08 Iheme Mordi I. Fluid transfer device
US20020127147A1 (en) * 2001-03-09 2002-09-12 Kacian Daniel L. Penetrable cap
US20040221905A1 (en) * 2003-05-05 2004-11-11 Chin-Kuang Luo Heat pipe having an elastic sealing member
US20060289668A1 (en) * 2005-06-03 2006-12-28 Joseph Szymczak Scent dispersing and storage apparatus and mehtod
US20080138376A1 (en) * 2005-05-13 2008-06-12 Anthony David Harman Preparation of Therapeutic Foam
US20110168292A1 (en) * 2010-01-12 2011-07-14 Medela Holding Ag Container with Sealed Cap and Venting System
US20140060696A1 (en) * 2011-10-26 2014-03-06 Panasonic Corporation Drug solution transfer method and drug solution transfer apparatus
US20140128832A1 (en) * 2012-11-08 2014-05-08 Fenwal, Inc. Rfid tag and blood container/system with integrated rfid tag

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1178512A (en) * 1914-05-15 1916-04-11 Thomas V Garlock Liquid-extractor.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1178512A (en) * 1914-05-15 1916-04-11 Thomas V Garlock Liquid-extractor.

Cited By (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3788369A (en) * 1971-06-02 1974-01-29 Upjohn Co Apparatus for transferring liquid between a container and a flexible bag
US3770026A (en) * 1971-09-17 1973-11-06 J Isenberg Apparatus and method for accurately loading syringes
US4121735A (en) * 1974-09-19 1978-10-24 Goldwell Gmbh, Chemische Fabrik H.E.Dotter System for quantity-controlled spraying of a liquid active ingredient
US4046145A (en) * 1976-06-29 1977-09-06 American Hospital Supply Corporation Syringe connector
US4321306A (en) * 1978-11-17 1982-03-23 Tsukasa Eguchi Rubber stopper for tight sealing
US4573994A (en) * 1979-04-27 1986-03-04 The Johns Hopkins University Refillable medication infusion apparatus
US4316941A (en) * 1979-10-02 1982-02-23 Asahi Glass Company Ltd. Rubber stopper for sealing
US4493348A (en) * 1981-06-29 1985-01-15 Pur/Acc Corporation Method and apparatus for orally dispensing liquid medication
US4410321A (en) * 1982-04-06 1983-10-18 Baxter Travenol Laboratories, Inc. Closed drug delivery system
US4411662A (en) * 1982-04-06 1983-10-25 Baxter Travenol Laboratories, Inc. Sterile coupling
US4458733A (en) * 1982-04-06 1984-07-10 Baxter Travenol Laboratories, Inc. Mixing apparatus
US4432755A (en) * 1982-04-06 1984-02-21 Baxter Travenol Laboratories, Inc. Sterile coupling
US4484920A (en) * 1982-04-06 1984-11-27 Baxter Travenol Laboratories, Inc. Container for mixing a liquid and a solid
US4489766A (en) * 1982-09-13 1984-12-25 Montada Benjamin V Syringe filling device
US5088996A (en) * 1984-04-16 1992-02-18 Kopfer Rudolph J Anti-aerosoling drug reconstitution device
US4850137A (en) * 1984-06-25 1989-07-25 Foster Charles W Device for watering and removing water from cut plant containers
US4666427A (en) * 1984-12-27 1987-05-19 Viggo Ab Fluid and particle absorbing body for apertures in injection instruments
US4582207A (en) * 1985-04-02 1986-04-15 Bristol-Myers Company Safety reservoir snap on overcap for parenteral drug container
US4756974A (en) * 1986-11-10 1988-07-12 The West Company Incorporated Elastomeric component for pharmaceutical devices
US5035689A (en) * 1989-03-13 1991-07-30 Schroeder Thomas J Luer-loc-tipped vial--syringe combination
US5409125A (en) * 1989-12-11 1995-04-25 Aktiebolaget Astra Unit dose container
US8573072B2 (en) 1999-05-14 2013-11-05 Gen-Probe Incorporated Method for removing a fluid substance from a sealed collection device
US20010039058A1 (en) * 1999-05-14 2001-11-08 Iheme Mordi I. Fluid transfer device
US20030207463A1 (en) * 1999-05-14 2003-11-06 Iheme Mordi I. Method for obtaining the contents of a fluid-holding vessel
US6716396B1 (en) 1999-05-14 2004-04-06 Gen-Probe Incorporated Penetrable cap
US6723289B2 (en) 1999-05-14 2004-04-20 Gen-Probe Incorporated Fluid transfer device
US20040105786A1 (en) * 1999-05-14 2004-06-03 Anderson Bruce W. Collection device
US20040152205A1 (en) * 1999-05-14 2004-08-05 Anderson Bruce W. Method for removing a fluid substance from a collection device
US6806094B2 (en) 1999-05-14 2004-10-19 Gen-Probe Incorporated Method for removing a fluid substance from a collection device
US8535621B2 (en) 1999-05-14 2013-09-17 Gen-Probe Incorporated Penetrable cap having rib structures
US20050059161A1 (en) * 1999-05-14 2005-03-17 Gen-Probe Incorporated Method for obtaining a fluid sample
US8334145B2 (en) 1999-05-14 2012-12-18 Gen-Probe Incorporated Pierceable cap having spaced-apart grooves
US8211710B2 (en) 1999-05-14 2012-07-03 Dickey Kathleen A Method for accessing the contents of a closed collection device
US8206662B2 (en) 1999-05-14 2012-06-26 Gen-Probe Incorporated Collection device including a penetrable cap having an absorbent pile fabric
US7435389B2 (en) 1999-05-14 2008-10-14 Gen-Probe Incorporated Sealed collection device having striated cap
US7276383B2 (en) 1999-05-14 2007-10-02 Gen-Probe Incorporated Method for obtaining the contents of a fluid-holding vessel
US8038967B2 (en) 1999-05-14 2011-10-18 Gen-Probe Incorporated Method for accessing the contents of a closed vessel containing a specimen retrieval device
US7309469B2 (en) 1999-05-14 2007-12-18 Gen-Probe Incorporated Collection device
US20080047371A1 (en) * 1999-05-14 2008-02-28 Gen-Probe Incorporated Penetrable cap having an absorbent material and method of using the same
US7648680B2 (en) 1999-05-14 2010-01-19 Gen-Probe Incorporated Method for accessing the contents of a closed vessel containing a specimen retrieval device
US20080134808A1 (en) * 1999-05-14 2008-06-12 Gen-Probe Incorporated Method for accessing the contents of a closed collection device with a modified pipette
US7927549B2 (en) 1999-05-14 2011-04-19 Gen-Probe Incorporated Method for accessing the contents of a closed collection device with a modified pipette tip
US7795036B2 (en) 1999-05-14 2010-09-14 Gen-Probe Incorporated Method for accessing the contents of a closed collection device
US20080245163A1 (en) * 1999-05-14 2008-10-09 Gen-Probe Incorporated Penetrable cap having rib structures
US20080118988A1 (en) * 1999-05-14 2008-05-22 Gen-Probe Incorporated Method for accessing the contents of a closed collection device
US20080152545A1 (en) * 1999-05-14 2008-06-26 Gen-Probe Incorporated Assembly containing a specimen retrieval device
US8052944B2 (en) 2001-03-09 2011-11-08 Gen-Probe Incorporated Penetrable cap
USRE45194E1 (en) 2001-03-09 2014-10-14 Gen-Probe Incorporated Penetrable cap
US7691332B2 (en) 2001-03-09 2010-04-06 Gen-Probe Incorporated Penetrable cap
US20100190215A1 (en) * 2001-03-09 2010-07-29 Gen-Probe Incorporated Penetrable cap
US8685347B2 (en) 2001-03-09 2014-04-01 Gen-Probe Incorporated Penetrable cap
US20020127147A1 (en) * 2001-03-09 2002-09-12 Kacian Daniel L. Penetrable cap
US20050079633A1 (en) * 2001-03-09 2005-04-14 Gen-Probe Incorporated Method for transferring a substance to or from a closed system
US6893612B2 (en) 2001-03-09 2005-05-17 Gen-Probe Incorporated Penetrable cap
US8057762B2 (en) 2001-03-09 2011-11-15 Gen-Probe Incorporated Penetrable cap
US7294308B2 (en) 2001-03-09 2007-11-13 Gen-Probe Incorporated Penetrable cap
US20090208966A1 (en) * 2001-03-09 2009-08-20 Gen-Probe Incorporated Method for removing a fluid substance from a closed system
US7824922B2 (en) 2001-03-09 2010-11-02 Gen-Probe Incorporated Method for removing a fluid substance from a closed system
US6880580B2 (en) * 2003-05-05 2005-04-19 Chin-Kuang Luo Heat pipe having an elastic sealing member
US20040221905A1 (en) * 2003-05-05 2004-11-11 Chin-Kuang Luo Heat pipe having an elastic sealing member
US20080138376A1 (en) * 2005-05-13 2008-06-12 Anthony David Harman Preparation of Therapeutic Foam
US20090148490A9 (en) * 2005-05-13 2009-06-11 Anthony David Harman Preparation of Therapeutic Foam
US20100260007A1 (en) * 2005-05-13 2010-10-14 Btg International Limited Preparation of therapeutic foam
US20060289668A1 (en) * 2005-06-03 2006-12-28 Joseph Szymczak Scent dispersing and storage apparatus and mehtod
US20110168292A1 (en) * 2010-01-12 2011-07-14 Medela Holding Ag Container with Sealed Cap and Venting System
US9296531B2 (en) 2010-01-12 2016-03-29 Medela Holding Ag Container with sealed cap and venting system
US20140060696A1 (en) * 2011-10-26 2014-03-06 Panasonic Corporation Drug solution transfer method and drug solution transfer apparatus
US20140128832A1 (en) * 2012-11-08 2014-05-08 Fenwal, Inc. Rfid tag and blood container/system with integrated rfid tag
US9579253B2 (en) * 2012-11-08 2017-02-28 Grifols Worldwide Operations Limited RFID tag and blood container/system with integrated RFID tag

Similar Documents

Publication Publication Date Title
US3509879A (en) Parenteral liquid container having frangible part structure
US3330281A (en) Combination syringe and vial mixing container
US3592245A (en) Universal dispensing device for intravenous medications
US3342180A (en) Disposable liquid-powder package and hypodermic syringe
US3459183A (en) Catheter placement unit with anesthetic
US3336924A (en) Two compartment syringe package
US3089490A (en) Disposable cartridge type hypodermic syringes
US3380450A (en) Sterile disposable plastic prefilled syringe
US6494865B1 (en) Intradermal delivery device including a needle assembly
US2561071A (en) Holder for subcutaneous administration of medicaments
US4636201A (en) Hypodermic syringe having a protective sheath cover
US4518385A (en) Disposable syringe for needleless injector
US3030955A (en) Plastic container
US3630199A (en) Unitized injection system
US5080654A (en) Fluid injection device for intravenous delivery system
US5893842A (en) Syringe needle isolation device
US5924584A (en) Container closure with a frangible seal and a connector for a fluid transfer device
US5195985A (en) Syringe having a retractable needle
US3923058A (en) Multi-chamber syringe
US3376866A (en) Medicament injector with attached vial
US4687467A (en) One-time use medical syringe invention
US4133314A (en) Extension transfer set
US4259956A (en) Certi-seal
US6537257B1 (en) Syringe with reciprocating, leak-proof needle guard
US20060184103A1 (en) Syringe safety device