Connect public, paid and private patent data with Google Patents Public Datasets

Diaphragm dispenser

Download PDF

Info

Publication number
US3572552A
US3572552A US3572552DA US3572552A US 3572552 A US3572552 A US 3572552A US 3572552D A US3572552D A US 3572552DA US 3572552 A US3572552 A US 3572552A
Authority
US
Grant status
Grant
Patent type
Prior art keywords
means
diaphragm
fluid
chambers
plunger
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
Perry W Guinn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PERRY W GUINN
Original Assignee
PERRY W GUINN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Images

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02Burettes; Pipettes
    • B01L3/021Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01FMEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00Apparatus requiring external operation and adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container without regard to weight and to deliver it
    • G01F11/02Apparatus requiring external operation and adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container without regard to weight and to deliver it with measuring chambers which expand or contract during measurement
    • G01F11/08Apparatus requiring external operation and adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container without regard to weight and to deliver it with measuring chambers which expand or contract during measurement of the diaphragm or bellows type
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0829Multi-well plates; Microtitration plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers

Abstract

The present invention comprises a diaphragm dispenser for fluids and includes plural charge-receiving chambers having respective variable upper extremities. The latter are defined by a diaphragm means which is selectively deformable, and in desired degrees, within said chambers as fluid pressure is applied to the upper side of the diaphragm. This is accomplished in one form of the invention by a plunger and, preferably, the same actuates a given hydraulic fluid exposed between the diaphragm and the plunger. The plunger is preferably calibrated so that a given depression of the operating piston thereof effects predetermined incremental displacements of respective portions of the diaphragm within the charged chambers so that the latter may receive and discharge respective portions of a test liquid in a manner hereinafter described.

Description

United States Patent [72] Inventor Perry W. Guinn 128 E. 5460 S. Apt. 8, Murray, Utah 84107 [21 App]. No. 844,830

[22] Filed July 25, 1969 [45] Patented Mar.30, 1971 [54] DIAPHRAGM DISPENSER 10 Claims, 6 Drawing Figs.

386.5, 263; 73/4254, 425.6; 141/245; l28/(Digest) 5, 218, 218 (C); 23/253, 259

3,343,422 9/1967 McSmith Primary Examiner-M. Henson Wood, Jr. Assistant Examiner-Edwin D. Grant Attorney-M. Ralph Shaffer ABSTRACT: The present invention comprises a diaphragm dispenser for fluids and includes plural charge-receiving chambers having respective variable upper extremities. The latter are defined by a diaphragm means which is selectively deformable, and in desired degrees, within said chambers as fluid pressure is applied to the upper side of the diaphragm. This is accomplished in one form of the invention by a plunger and, preferably, the same actuates a given hydraulic fluid exposed between the diaphragm and the plunger. The plunger is (inquired) preferably calibrated so that a given depression of the operating piston thereof effects predetermined incremental displace- [56] References ments of respective portions of the diaphragm within the UNITED STATES PATENTS charged chambers so that the latter may receive and discharge 2,063,430 12/ 1936 Graser 222/3865 respective portions of a test liquid in a manner hereinafter 3,261,208 7/ 1966 Fisher 73/4256 described.

34 B 35 32 3 7 V a,

---J'L'* ll -r- Q is C A -=;re= i0 ll-F I I ,ac o. t 2 It I I w l l I J d, I Q 4 t 1J v I r 1 1 H l- -4 i- W 5 '3 I I 5 k [2 I4 L PATENTEUHARSOISYI FIG. 5

FIG. 2

, A V//\ VA IVA VA V/AWX FIG. 3

3a FIG.6

INVENTOR. PERRY W. GUINN HIS ATTORNEY device to be filled in the desired manner and, subsequently,

discharged as required.

In laboratory work it is frequently desirous to have accessible some type of dispenser for filling individual depressions in a tray, a plurality of test tubes, and so forth. Frequently it is desirous to test the effectiveness of drugs, and bacterial and antibiotic solutions of various types. It is convenient in such instances to provide a tray resembling a muffin tin used by housewives for baking purposes, which tray has a plurality of closely spaced depressions. Laboratory trays of such construction are well known in the art and are often used by laboratory technicians. In lieu of such a tray, of course, a series of tubes may be disposed in conventional test tube rack can be thus positioned proximate to each other.

Assume by way of example that it is desired for testing purposes that equal amounts of solution be si disposed in a plurality of test tubes or in a plurality of the depressions within the laboratory tray as above-described. r, assume the the reverse case wherein the equivalent amounts of different antibiotic solutions are disposed in the respective test tubes or the respective tray depressions arid that, for test purposed, one wishes to deposit an equivalent amount of a toxic bacterial solution in each of the test tubesor tray depressions to determine the relative effectiveness of these solutions.

By using the above procedure the relative effectiveness of either the same antibiotic agent, for example, upon different, toxic, bacterial solutions may be determined by conventional techniques including litmus papers,'preparation of cover slips and so forth. correspondingly, the relative effectiveness of a plural number of equivalent amounts of antibiotic solutions predisposed in test tubes or in the depressions of the laboratory tray and the effectiveness thereof upon given bacterial solution may be predetermined where in the dispenser is used for depositing equivalent amounts of a given bacterial solution in the individual test tubes or tray depressions.

The difficulty in the past has been one of conveniently depositing identical amounts of a given liquid into a plurality of receptacles. Frequently this is done laboriously by hand by use of conventional syringe filled repeatedly for successive discharges in respective ones of the chosen receptacles.

The present invention avoids these above difficulties in a manner as hereinafter described.

Accordingly, a principal object of the present invention is to provide a new and improved dispenser constructed to receive and discharge simultaneously a series of multiple charges of liquid.

A further object of the invention is to provide a dispenser device including plural charge chambers defined at an upper respective end thereof by deformable diaphragm means.

A further object of the invention is to provide a multiple charge dispenser incorporating diaphragm means wherein a syringe is usable in conjunction with an operative fluid, such as a hydraulic liquid, for alternatively depressing the diaphragm means within the individual charged chambers prior to charge takeup, then permitting the diaphragm means to assume its normal position and thereby reduce the pressure areas within the charged chambers so fluid is drawn upwardly therein; subsequently, to operate the syringe so that the operative fluid associated therewith depresses the diaphragm means so as to discharge liquid from the individual charge chambers of the device.

In accordance with the present invention the device incorporatcs a base having plural charge chambers. These preferably include mutually spaced bores and, in a preferred form of the invention, include depending tubular devices communicating with and mounted within the bores. The individual chambers of the device have an upper extremity defined by diaphragm means, preferably taking the form of a unitary diaphragm. Disposed above the diaphragm is fluid pressure cavity leading to a piston-cylinder combination preferably taking the form of a syringe. While the device can be operated by air, preferably a hydraulic fluid is disposed between the plunger of the syringe and the hollow cavity above the diaphragm. Depression of the plunger in the syringe forces the diaphragm downwardly into the individual charge chambers so as to express a portion of the 'air outwardly therefrom and permit the ends of the charge chamber structure to bc deposited in a given liquid. Release of pressure on the syringe either through spring pressure or drawing the plunger backwardly by hand creates a reduced pressure area above the diaphragm so as to allow the diaphragm portions to return upwardly, thereby permitting the charge chamber structures to draw fluid upwardly. Thereafter, the device is disposed over a suitable container such as a multiple depression laboratory tray or even a series of test tubes. Subsequent depression of the plunger again depresses the diaphragm means over the individual chambers so as to expel the fluid into the individual depressions of the tray or the individual test tubes used.

The features of the present invention which are believed to be novel are set forth with particularity in the appended claims. The present invention, both as to its organization and manner of operation, together with further objects and advantages thereof, may best be understood by reference to the following description, taken in connection with the accompanying drawings in which:

FIG. I is a perspective view of the device incorporating the features of the present invention.

FIG. 2 is a transverse vertical cross section of the device and is taken along the line 2-2 in FIG. 1.

FIG. 3 is a longitudinal vertical section taken along the line 3-3 in FIG. l and is shown in reduced scale.

FIGS. 4--6 are similar to FIG. 3, illustrating, as to FIG. 4, that the plunger of the syringe is depressed so as to deform downwardly the diaphragm within the several charged chamber cavities immediately prior to and at the insertion time of the cavity tubes within a test liquid; as to FIG. 5, the release or withdrawal of the syringe plunger so that tubes may fill; and, as to FIG. 6, an expulsion of the liquid previously drawn upwardly into the charge cavity tubes, this time by a forward depression of the plunger of the syringe.

In FIG. I the device I0 of the present invention is shown to include a pair of base 11 and 112 having upstanding posts l3- l6 which serve as mounts for lower member 17. Lower member 17 includes plural bores 18 which receive the hollow cylindrical stems l9 of charge tubes 20. These charge tubes 20 will each include a depending, hollow, needlelike cylinder 21, hub 22, and the stub cylinder l9. Shoulder 23 abuts against the lower surface 24, of member ll7.

Intermediate member 25 includes plural, enlarged bores 26 which communicate with bores I8 and the hollow interiors of stub cylinders 19 in the manner indicated in FIG. 3. A diaphragm 27 is fixedly secured between the adjacent surfaces of intermediate member 25 upper member 28 and in constitution may comprise a thin, latex rubber or neoprene sheet, by way of example, of the order of 0.0 l 0 inches thick.

Upper member 28 includes a milled area 29 forming a cavity contiguous with the upper surface of diaphragm 27 and also communicating with a bore 30. Bore 30 receives the forward end of a flexible hose 31 attached to syringe 32. Syringe 32, of course, includes the usual cylinder 33 and plunger 34 operating together in a well-known manner. Screws 34' may be used to secure the upper member 28 to lower member 17 in a manner indicated as by a threaded connection. Alternatively, other means can be used; however, the manner of attachment should be such that the diaphragm is rigidly clamped or otherwise secured as between the adjaeent surfaces of intermediate member and upper member 28. In a preferred form of the invention a spring 35 may be employed, if desired, as a returning device for the plunger 34. While the device may use an air or other gaseous medium, it is preferably from a point of view of accuracy that a hydraulic fluid 36 be employed in the manner indicated in FIG. 6.

FIGS. 3-6 illustrate the operation of the device. Initially, of course, the plunger 32 will be disposed in the manner shown in FIG. 3. When it is desired to insert the charge chamber tubular extensions 21 into a given liquid, then the plunger will be depressed in the manner shown in FIG. 4 and the tubes inserted in the given liquid as seen in the same FIG. While the tubes are contained within the test fluid 37 the pressure on the plunger is released in the manner illustrated in FIG. 5 such that fluid flows upwardly into these needlelike cylinders 21. Subsequently, the device is lifted upwardly and moved to a position at which a laboratory tray 37, having individual container like depressions 38, is disposed; It has heretofore been explained that these individual depressions may contain solutions of individual character, whether bacterial or antibacterial, by way of example. At this point the plunger is advanced forwardly in a manner shown in H0. 6 so as to expel the individual charges of liquid out of the needlelike cylinders 21 of charge chambers C of the device. Accordingly; amounts of liquid will be deposited in each of the container depressions 38 of laboratory tray 37.

It is noted that the device may be calibrated as indicated at B in FlG. 1 so that a given plunger depression of, say, 5 centimeters will produce a l centimeter depression of each of the membrane portions P of members 27. Thus, there will be rendered possible a l centimeter filling of each charge chamber C. This characteristic of the invention is feasible with a high degree of accuracy, and especially where a noncompressible hydraulic fluid as at 36 is utilized in the invention. The fluid, of course, will be of such an amount that when the plunger is at zero position the diaphragm portions above the individual chambers or bores 26 are nondepressed. This is made possible due to the surface tension of the membrane.

What is achieved, therefore, is an a new and improved device for dispensing simultaneously, multiple charges of liquid into a laboratory tray, a series of test tubes, or other series of chambers. This can be accomplished very accurately where a syringe 32 of the device is calibrated as indicated, and especially where a hydraulic medium such as a noncompressible hydraulic oil liquid is disposed within the tube 31 and cavity 29. The diaphragm is effective to isolate the charge cavities C from the hydraulic line and, in addition, to provide for a desired displacement of portions of the membrane above the various charged chambers to accomplish intake and discharge in the manner above-described.

If desired, member 17 with dispenser charge tubes may comprise a replacable, unitary, molded plastic part which is disposable after use with a given liquid that may be toxic.

While particular embodiments of the present invention have been shown and described, it will be obvious to those skilled in the art that changes and modifications may be made without departing from this invention in its broader aspects.

I claim:

1. A fluid dispenser including, in combination, structure defining plural, vertically disposed chambers, a cavity horizontally disposed over said chambers. flexible diaphragm means disposed between said chambers and said cavity and forming a lower boundary of said cavity, fluid means disposed in said cavity for depressing said diaphragm means within said chambers when said fluid means is under pressure, and means for releasably applying pressure to said fluid means connected to said structure and communicating with said cavity above said diaphragm means.

2. Structure according to claim 1 wherein said pressure applying means comprises a syringe.

3. Structure according to claim 1 wherein said pressure applying means comprises a syringe having a cylinder. 21 reciprocatingly translatable plunger opcratively disposed within said cylinder, and a tube afiixed to an and communicating with said cylinder and said cavity of said structure above said diaphragm means, said fluid means filling said cylinder beneath said plunger, said tube, and said cavity.

4. Structure according to claim I wherein said fluid means corn rises a hydraulic liquid. I I I I I 5. trueture according to claim I wherein said dispenser mcludes plural, needlelike cylinders communicating with said chambers and fixedly disposed with respect to and depending from said defining structure.

6. The dispenser of claim 1 wherein said diaphragm means comprises an elastomeric diaphragm sheet disposed over said chambers.

7. The dispenser of claim I wherein said fluid means comprises a gaseous medium.

8. The dispenser of claim 1 wherein said fluid means comprises a hydraulic liquid, said pressure means comprising a syrmge.

9. The dispenser of claim 3 wherein said syringe includes a plunger return spring.

10. The structure of claim 5 wherein said dispenser includes end support means disposed upon opposite sides of said cylinders and depending therebeneath.

Claims (10)

1. A fluid dispenser including, in combination, structure defining plural, vertically disposed chambers, a cavity horizontally disposed over said chambers, flexible diaphragm means disposed between said chambers and said cavity and forming a lower boundary of said cavity, fluid means disposed in said cavity for depressing said diaphragm means within said chambers when said fluid means is under pressure, and means for releasably applying pressure to said fluid means connected to said structure and communicating with said cavity above said diaphragm means.
2. Structure according to claim 1 wherein said pressure applying means comprises a syringe.
3. Structure according to claim 1 wherein said pressure applying means comprises a syringe having a cylinder, a reciprocatingly translatable plunger operatively disposed within said cylinder, and a tube affixed to an and communicating with said cylinder and said cavity of said structure above said diaphragm means, said fluid means filling said cylinder beneath said plunger, said tube, and said cavity.
4. Structure according to claim 1 wherein said fluid means comprises a hydraulic liquid.
5. Structure according to claim 1 wherein said dispenser includes plural, needlelike cylinders communicating with said chambers and fixedly disposed with respect to and depending from said defining structure.
6. The dispenser of claim 1 wherein said diaphragm means comprises an elastomeric diaphragm sheet disposed over said chambers.
7. The dispenser of claim 1 wherein said fluid means comprises a gaseous medium.
8. The dispenser of claim 1 wherein said fluid means comprises a hydraulic liquid, said pressure means comprising a syringe.
9. The dispenser of claim 3 wherein said syringe includes a plunger return spring.
10. The structure of claim 5 wherein said dispenser includes end support means disposed upon opposite sides of said cylinders and depending therebeneath.
US3572552A 1969-07-25 1969-07-25 Diaphragm dispenser Expired - Lifetime US3572552A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US84483069 true 1969-07-25 1969-07-25

Publications (1)

Publication Number Publication Date
US3572552A true US3572552A (en) 1971-03-30

Family

ID=25293741

Family Applications (1)

Application Number Title Priority Date Filing Date
US3572552A Expired - Lifetime US3572552A (en) 1969-07-25 1969-07-25 Diaphragm dispenser

Country Status (1)

Country Link
US (1) US3572552A (en)

Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3807959A (en) * 1972-10-16 1974-04-30 Biochemical Procedures Inc Thin layer chromatography spotting device
US3807235A (en) * 1971-10-13 1974-04-30 Hoffmann La Roche Micropipetting apparatus
US3827286A (en) * 1971-07-29 1974-08-06 Gelman Instr Co Device for blood sedimentation rate estimation
US3982438A (en) * 1975-06-23 1976-09-28 The Salk Institute For Biological Studies Multiple sample pipetting apparatus
US4158035A (en) * 1978-03-15 1979-06-12 Byrd William J Multiple sample micropipette
US4215092A (en) * 1976-04-08 1980-07-29 Osmo A. Suovaniemi Apparatus for liquid portioning and liquid transferring
USRE30562E (en) * 1979-02-22 1981-03-31 Immunological testing devices
US4511534A (en) * 1982-05-26 1985-04-16 John T. Bennett Liquid transfer device
US4532805A (en) * 1984-05-29 1985-08-06 Flesher Robert W Pipette system
US4537231A (en) * 1983-08-29 1985-08-27 Becton, Dickinson And Company Dispenser apparatus for simultaneously dispensing predetermined equal volumes of liquid including a disposable dispenser module
US4588554A (en) * 1982-02-25 1986-05-13 Fluilogic Systems Oy Reagent package
WO1986003008A1 (en) * 1984-11-13 1986-05-22 Cedars-Sinai Medical Center Portable blood typing apparatus and method
US4753775A (en) * 1985-04-12 1988-06-28 E. I. Du Pont De Nemours And Company Rapid assay processor
US4892710A (en) * 1987-07-07 1990-01-09 Bioprobe International, Inc. Cartridge assembly with multi-purpose closure tubing
US5085345A (en) * 1985-04-12 1992-02-04 Wells John R Hydraulic dispenser
US5193403A (en) * 1988-04-18 1993-03-16 Epr Labautomation Ag Pipetting device
US5334352A (en) * 1992-09-23 1994-08-02 Icn Biomedicals, Inc. Manifold construction
US5343909A (en) * 1992-12-17 1994-09-06 Jack Goodman Liquid transfer device
US5344397A (en) * 1992-06-26 1994-09-06 Advanced Surgical, Inc. Cholangiogram catheter
WO1998030254A3 (en) * 1997-01-10 1998-12-03 Univ Emory Sample collection and drug delivery apparatus for freely-moving tethered laboratory animals
WO2002092228A2 (en) * 2001-05-11 2002-11-21 Allegro Research Limited A method and device for dispensing of droplets
US6593146B1 (en) * 1999-02-16 2003-07-15 Brand Gmbh & Co. Kg Fabrik Fur Laborgerate Metering device and method for operating a metering device
US20030223910A1 (en) * 2002-02-12 2003-12-04 Molecular Devices Corp. Pipettor systems and components
US20040018119A1 (en) * 2002-07-23 2004-01-29 Peter Massaro Liquid handling tool having porous plunger
US20040033168A1 (en) * 2002-05-13 2004-02-19 Becton, Dickinson And Company Self aliquoting sample storage plate
US20040141885A1 (en) * 2002-02-12 2004-07-22 Molecular Devices Corp. Pipettor systems and components
US20060130928A1 (en) * 2004-12-20 2006-06-22 Palo Alto Research Center Incorporated Bio-ejector filling stops to facilitate efficient filling
DE102005014572A1 (en) * 2005-03-31 2006-10-12 Eppendorf Ag pipetting
DE102007005323A1 (en) * 2007-01-29 2008-07-31 Bioplan Consulting Gmbh Suction device has multiple suction needles and vacuum chamber, in which suction needles empty and connection is provided for vacuum source
US7427379B1 (en) * 1999-03-19 2008-09-23 Biotage Ab Liquid dispensing apparatus
US20080269680A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Systems and methods for reservoir filling
US20080269682A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
WO2009049842A1 (en) * 2007-10-11 2009-04-23 Brand Gmbh + Co Kg Dosing device for liquids
US20090198215A1 (en) * 2007-04-30 2009-08-06 Medtronic Minimed, Inc. Adhesive patch systems and methods
US20110190700A1 (en) * 2007-04-30 2011-08-04 Medtronic Minimed, Inc. Reservoir systems and methods
RU2456550C1 (en) * 2011-02-24 2012-07-20 Государственное научное учреждение Всероссийский научно-исследовательский институт агрохимии им. Д.Н. Прянишникова Multi-position batcher-collector device
US8597270B2 (en) 2007-04-30 2013-12-03 Medtronic Minimed, Inc. Automated filling systems and methods
US9199030B2 (en) 2005-05-06 2015-12-01 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
WO2017212469A1 (en) * 2016-06-09 2017-12-14 Spacepharma SA Multichannel liquid delivery system

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2063430A (en) * 1935-09-24 1936-12-08 Eugene D Lichtenberg Liquid dispenser
US3261208A (en) * 1964-05-13 1966-07-19 Timothy L Fisher Automatic pipette
US3343422A (en) * 1965-08-12 1967-09-26 Dwight G Mcsmith Pipette safety device

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2063430A (en) * 1935-09-24 1936-12-08 Eugene D Lichtenberg Liquid dispenser
US3261208A (en) * 1964-05-13 1966-07-19 Timothy L Fisher Automatic pipette
US3343422A (en) * 1965-08-12 1967-09-26 Dwight G Mcsmith Pipette safety device

Cited By (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3827286A (en) * 1971-07-29 1974-08-06 Gelman Instr Co Device for blood sedimentation rate estimation
US3807235A (en) * 1971-10-13 1974-04-30 Hoffmann La Roche Micropipetting apparatus
US3807959A (en) * 1972-10-16 1974-04-30 Biochemical Procedures Inc Thin layer chromatography spotting device
US3982438A (en) * 1975-06-23 1976-09-28 The Salk Institute For Biological Studies Multiple sample pipetting apparatus
US4215092A (en) * 1976-04-08 1980-07-29 Osmo A. Suovaniemi Apparatus for liquid portioning and liquid transferring
US4158035A (en) * 1978-03-15 1979-06-12 Byrd William J Multiple sample micropipette
USRE30562E (en) * 1979-02-22 1981-03-31 Immunological testing devices
US4588554A (en) * 1982-02-25 1986-05-13 Fluilogic Systems Oy Reagent package
US4511534A (en) * 1982-05-26 1985-04-16 John T. Bennett Liquid transfer device
US4537231A (en) * 1983-08-29 1985-08-27 Becton, Dickinson And Company Dispenser apparatus for simultaneously dispensing predetermined equal volumes of liquid including a disposable dispenser module
US4532805A (en) * 1984-05-29 1985-08-06 Flesher Robert W Pipette system
WO1986003008A1 (en) * 1984-11-13 1986-05-22 Cedars-Sinai Medical Center Portable blood typing apparatus and method
US4650662A (en) * 1984-11-13 1987-03-17 Cedars-Sinai Medical Center Portable blood typing apparatus and method
US4753775A (en) * 1985-04-12 1988-06-28 E. I. Du Pont De Nemours And Company Rapid assay processor
US5085345A (en) * 1985-04-12 1992-02-04 Wells John R Hydraulic dispenser
US4892710A (en) * 1987-07-07 1990-01-09 Bioprobe International, Inc. Cartridge assembly with multi-purpose closure tubing
US5193403A (en) * 1988-04-18 1993-03-16 Epr Labautomation Ag Pipetting device
US5344397A (en) * 1992-06-26 1994-09-06 Advanced Surgical, Inc. Cholangiogram catheter
US5334352A (en) * 1992-09-23 1994-08-02 Icn Biomedicals, Inc. Manifold construction
US5343909A (en) * 1992-12-17 1994-09-06 Jack Goodman Liquid transfer device
WO1995000392A1 (en) * 1993-06-25 1995-01-05 Jack Goodman Liquid transfer device
WO1998030254A3 (en) * 1997-01-10 1998-12-03 Univ Emory Sample collection and drug delivery apparatus for freely-moving tethered laboratory animals
US6593146B1 (en) * 1999-02-16 2003-07-15 Brand Gmbh & Co. Kg Fabrik Fur Laborgerate Metering device and method for operating a metering device
US7427379B1 (en) * 1999-03-19 2008-09-23 Biotage Ab Liquid dispensing apparatus
WO2002092228A2 (en) * 2001-05-11 2002-11-21 Allegro Research Limited A method and device for dispensing of droplets
WO2002092228A3 (en) * 2001-05-11 2003-03-13 Allegro Res Ltd A method and device for dispensing of droplets
US20030223910A1 (en) * 2002-02-12 2003-12-04 Molecular Devices Corp. Pipettor systems and components
US20040141885A1 (en) * 2002-02-12 2004-07-22 Molecular Devices Corp. Pipettor systems and components
US7354774B2 (en) * 2002-05-13 2008-04-08 Becton, Dickinson And Company Self aliquoting sample storage plate
US20040033168A1 (en) * 2002-05-13 2004-02-19 Becton, Dickinson And Company Self aliquoting sample storage plate
US20040018119A1 (en) * 2002-07-23 2004-01-29 Peter Massaro Liquid handling tool having porous plunger
WO2004009238A1 (en) * 2002-07-23 2004-01-29 Protedyne Corporation Liquid handling tool having hollow plunger
US7438857B2 (en) 2002-07-23 2008-10-21 Protedyne Corporation Liquid handling tool having porous plunger
US7757730B2 (en) 2004-12-20 2010-07-20 Palo Alto Research Center Incorporated Bio-ejector filling stops to facilitate efficient filling
US7775246B2 (en) 2004-12-20 2010-08-17 Palo Alto Research Center Incorporated Bio-ejector filling stops to facilitate efficient filling
US7387139B2 (en) * 2004-12-20 2008-06-17 Palo Alto Research Center Incorporated Bio-ejector filling stops to facilitate efficient filling
US20060130928A1 (en) * 2004-12-20 2006-06-22 Palo Alto Research Center Incorporated Bio-ejector filling stops to facilitate efficient filling
DE102005014572B4 (en) * 2005-03-31 2007-01-04 Eppendorf Ag pipetting
DE102005014572A1 (en) * 2005-03-31 2006-10-12 Eppendorf Ag pipetting
US9199030B2 (en) 2005-05-06 2015-12-01 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
DE102007005323A1 (en) * 2007-01-29 2008-07-31 Bioplan Consulting Gmbh Suction device has multiple suction needles and vacuum chamber, in which suction needles empty and connection is provided for vacuum source
US8613725B2 (en) 2007-04-30 2013-12-24 Medtronic Minimed, Inc. Reservoir systems and methods
US9205191B2 (en) 2007-04-30 2015-12-08 Medtronic Minimed, Inc. Automated filling systems and methods
US20090198215A1 (en) * 2007-04-30 2009-08-06 Medtronic Minimed, Inc. Adhesive patch systems and methods
US9522225B2 (en) 2007-04-30 2016-12-20 Medtronic Minimed, Inc. Adhesive patch systems and methods
US20110190700A1 (en) * 2007-04-30 2011-08-04 Medtronic Minimed, Inc. Reservoir systems and methods
US9089641B2 (en) 2007-04-30 2015-07-28 Medtronic Minimed, Inc. Automated filling systems and methods
US20080269682A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8434528B2 (en) * 2007-04-30 2013-05-07 Medtronic Minimed, Inc. Systems and methods for reservoir filling
US20080269680A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Systems and methods for reservoir filling
US8597270B2 (en) 2007-04-30 2013-12-03 Medtronic Minimed, Inc. Automated filling systems and methods
US8597243B2 (en) 2007-04-30 2013-12-03 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US20100243675A1 (en) * 2007-10-11 2010-09-30 Brand Gmbh + Co Kg Dosing device for liquids
WO2009049842A1 (en) * 2007-10-11 2009-04-23 Brand Gmbh + Co Kg Dosing device for liquids
US8420027B2 (en) 2007-10-11 2013-04-16 Brand Gmbh + Co Kg Dosing device for liquids
RU2456550C1 (en) * 2011-02-24 2012-07-20 Государственное научное учреждение Всероссийский научно-исследовательский институт агрохимии им. Д.Н. Прянишникова Multi-position batcher-collector device
WO2017212469A1 (en) * 2016-06-09 2017-12-14 Spacepharma SA Multichannel liquid delivery system

Similar Documents

Publication Publication Date Title
US3682174A (en) Syringe for injection of freshly mixed liquid-powder
US3563415A (en) Multidrop adapter
US3343422A (en) Pipette safety device
US3310002A (en) Pipette pump
US3319837A (en) Dispensing device
US4296071A (en) Pipette with elastic bellows
US4570829A (en) Toothpaste dispenser
US4859336A (en) Filtering device for dispensing and filtering from samples
US3646817A (en) Pipette
US3244328A (en) Dispensing from plural sources
US6843652B2 (en) Single dose dental impression material delivery system and method
US5908054A (en) Fluid dispersion and delivery assembly and method
US4168020A (en) Dispensing apparatus for discharging liquid or creamy products
US5454268A (en) Double-plunger liquid displacement syringe pipet
US5223225A (en) Scale-marked pipet tip for precision dispensing of fluids over a large range of volumes
US984037A (en) Syringe.
US4067499A (en) Non-aerosol continuous spray dispenser
US4027785A (en) Dual pump colorant dispenser
US2595493A (en) Liquid extracting apparatus
US2653604A (en) Injection device
US2515956A (en) Syringe
US5405056A (en) Stereo dispensing container and system
US3766785A (en) Automatic pipette
US3197285A (en) Sampling machine
US4921142A (en) Manually operable fluid dispenser