US3572345A - Strap for a heart stimulator - Google Patents

Strap for a heart stimulator Download PDF

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Publication number
US3572345A
US3572345A US3572345DA US3572345A US 3572345 A US3572345 A US 3572345A US 3572345D A US3572345D A US 3572345DA US 3572345 A US3572345 A US 3572345A
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United States
Prior art keywords
stimulator
prolongations
strap
heart
organ
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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Michel Joseph Auphan
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US Philips Corp
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US Philips Corp
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Publication date
Priority to FR34749A priority Critical patent/FR1460772A/en
Priority to FR141591A priority patent/FR94491E/en
Application filed by US Philips Corp filed Critical US Philips Corp
Application granted granted Critical
Publication of US3572345A publication Critical patent/US3572345A/en
Assigned to HONEYWELL B.V. AMSTERDAM,A SUBSIDIARY OF THE NETHERLANDS OF HONEYWELL INC. A DE CORP. reassignment HONEYWELL B.V. AMSTERDAM,A SUBSIDIARY OF THE NETHERLANDS OF HONEYWELL INC. A DE CORP. ASSIGNOR ASSIGNS THE ENTIRE INTEREST, SUBJECT TO LICENSE RECITED. (SEE RECORDS FOR DETAILS). Assignors: U.S. PHILIPS CORPORATION
Anticipated expiration legal-status Critical
Application status is Expired - Lifetime legal-status Critical

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372Arrangements in connection with the implantation of stimulators
    • A61N1/375Constructional arrangements, e.g. casings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0587Epicardial electrode systems; Endocardial electrodes piercing the pericardium

Abstract

A SUPPORTING STRAP OF A SYNTHETIC RESIN FOR FASTENING AN OSCILLATING HEART STIMULATOR IN THE HUMAN BODY, SAID STRAP SURROUNDING THE STIMULATOR AND BEING PROVIDED WITH PROLONGATIONS, WHICH ARE DIVIDED AND EXTEND IN OPPOSITE DIRECTIONS, EACH PAIR OF PROLONGATIONS HAVING THEIR FREE ENDS INTERCONNECTED FOR BEING FASTENED TO A STATIONARY ORGAN AND AN ORGAN MOVING RHYTHMICALLY WITH THE HEART-BEAT RESPECTIVELY.

Description

March 23, 1971 M. J. AUPHAN 3,572,345

STRAP FOR A HEART STIMULA'TOR Filed Jan. 2'7, 1969 INVENTOR.

BY MCHE'L J. AUP'HAN M 265 N T United States Patent 3,572,345 STRAP FOR A HEART STIMULATOR Michel Joseph Anphan, Neuilly, France, assignor to U.S. Philips Corporation, New York, N.Y. Filed Jan. 27, 1969, Ser. No. 794,065 Claims priority, applicatilon France, Feb. 28, 1968,

14 ,59 Int. Cl. A61h 31/00; A6ln 1/36 US. Cl. 128-418 3 Claims ABSTRACT OF THE DISCLOSURE The invention relates to a supporting strap for an oscillating heart stimulator of the kind in which electrical pulses are produced by means of an electro-dynamic magnet system comprising an oscillating member as described in US. Pat. No. 3,486,506, and pending application 742,880, filed July 5, 1968.

Such a stimulator is arranged inside the human body in the proximity of the cardiac muscle and connected therewith. Provisions are made for the movements of the cardiac muscle to be transferred to the cabinet of the stimulator, which thus performs a rotational movement. Such a stimulator is operative as the result of a rotary movement during each heartbeat.

It is not a simple operation to arrange the heart stimulator in a correct manner and to establish the desired connections. Excessively long connections with internal organs, in proper movement, do not insure that the required rotary movement will be sufiiciently constant for reliable operation of the electro-dynamic system, whereas short connections are likely to break off soon.

An object of the invention is to provide a means to avoid these disadvantages. According to the invention the metal cabinet including the mover of the stimulator is embedded in a plastic sheath provided with prolongations projecting laterally in opposite directions, each consisting of two strips, one of which is extendable and the other having a greater rigidity. The interconnected ends of the prolongations form points of connection for arranging the stimulator in place between a substantially stationary organ and an organ moved by the heartbeat inside the human body.

The ends of the two prolongations are fastened in the appropriate manner to the relevant internal organs.

One embodiment of the supporting ,strap according to the invention will be described with reference to the drawing, which is a perspective view of the present invention shown in place and attached to the appropriate organs within the human body.

The heart stimulator 5 is encapsulated in a support ng strap of a synthetic resin with the exception of a portion of the metal cabinet, which forms the non-active electrode of the stimulator. The strap consists Partly of an encapsulation and partly of laterally projecting prolongatrons 6, and 7, 11, also of a synthetic resin. The prolongations 6 and 7 are fairly rigid, whereas the prolongations 10 and 11 are extendable. The prolongations 6 and 10 have their free ends connected with each other; the

prolongations 7 and 11 projecting to the other side are likewise interconnected. The joined prolongations 6 and 10 form a fastening point for the stimulator and the joined prolongations 7 and 11 form a further fastening point. The latter fastening point should be connected with an organ 4, which is independent of the cardiac movements and which is stationary, whereas the other fastening point is connected at a place 2 of the cardiac muscle 1, which place moves strongly during the heart function.

The place 2 of the heart performs movements substantially horizontally from left to right parallel to the ribs during the operation of the heart.

The extensible parts 10 and 11 of the strap extend during each expansion of the heart and then bring the stimulator cabinet 5 back into the initial position so that a rotary movement is produced. The stationary organ for fastening the end 7 of the strap may be formed by a rib 4 at the level of the heart cavities. The end of the prolongation 6 is provided with a cup-shaped member 3 of a synthetic resin, which surrounds the heart-tip and may be fastened, if necessary, by a few stitches to the surface of the cardiac muscle.

The active electrode 8 of the heart stimulator 5 is located at the centre of the member 3. The electrode is connected by a wire 9 embedded in the synthetic resin with the stimulator 5 and pressed over a few millimetres into the cardiac muscle. The member 3 prevents a displacement of the electrode with respect to the heart-tip and hence damage of the muscular tissue.

It is important that the synthetic resin employed should not irritate the ambient tissue. The material has to be sufiiciently elastic to ensure that the two laterally projecting prolongations of the strap can move away from each other and back towards each other over some distance between the prolongations 6 and 10 and between the prolongations 7 and 11, so that an oscillating motion of the stimulator 5 of a few degrees, for example, 5 to 10, is effected.

The supporting strap according to the invention for a self-oscillating heart stimulator is capable of establishing a simple connection between the relevant internal body parts and provides the possibility of achieving a durable, reliable operation of the stimulator.

What is claimed is:

1. A supporting strap for an oscillating heart stimulator of the kind in which electrical pulses are produced by means of an electro-dynamic magnet system comprising an oscillating member and having a metal cabinet comprising, a sheath of plastic material for holding therein said metal cabinet, a pair of prolongations attached at one end thereof to and projecting laterally in opposite directions from said sheath, each of said prolongations comprising two strips one of which is extendable the other of which is relatively rigid, said strips interconnecting and terminating to form the other end of said prolongations, the interconnected ends of said prolongations forming fastening points, one of said points adapted to be fastened to a stationary organ and the other point adapted to be fastened to an organ moved by the heart-beat inside the human body, so that said stimulator will be arranged substantially between said organs.

2. A supporting strap as claimed in claim 1 further comprising a cup-shaped member attached to one of said fastening points, the shape of said member corresponding to the shape of the cardiac muscle.

3. A supporting strap as claimed in claim 2 wherein said sheath and said straps are made of synthetic resin material and further comprising an electrode accommodated in said cup-shaped member and a Wire embedd ed OTHER REFERENCES 2 thetfgynthefilc retsm p g electrode Wlth Myers et 211.: American Journal of Medical Electron- 6 21C 1V6 V0 age 611111118. 0 e S lmu a 01'. ics OctDec" pp.

References Cited 5 WILLIAM E. KAMM, Primary Examiner UNITED STATES PATENTS 45 1 7 6 2 P U.S.CI.X .R. 3, 6, 34 /19 9 K0 1 8 19( 128419;248 317 3,486,506 12/1969 Auphan 128419(P)

US3572345D 1965-10-13 1969-01-27 Strap for a heart stimulator Expired - Lifetime US3572345A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR34749A FR1460772A (en) 1965-10-13 1965-10-13 Pacemaker
FR141591A FR94491E (en) 1965-10-13 1968-02-28 Pacemaker.

Publications (1)

Publication Number Publication Date
US3572345A true US3572345A (en) 1971-03-23

Family

ID=8646669

Family Applications (1)

Application Number Title Priority Date Filing Date
US3572345D Expired - Lifetime US3572345A (en) 1965-10-13 1969-01-27 Strap for a heart stimulator

Country Status (6)

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US (1) US3572345A (en)
BE (1) BE728990A (en)
DE (1) DE1906478B2 (en)
FR (1) FR94491E (en)
GB (1) GB1231121A (en)
NL (1) NL6902877A (en)

Cited By (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3683933A (en) * 1970-06-22 1972-08-15 Peter B Mansfield Implantable tissue stimulator with a porous anchoring enclosure
US4030509A (en) * 1975-09-30 1977-06-21 Mieczyslaw Mirowski Implantable electrodes for accomplishing ventricular defibrillation and pacing and method of electrode implantation and utilization
US5058584A (en) * 1990-08-30 1991-10-22 Medtronic, Inc. Method and apparatus for epidural burst stimulation for angina pectoris
WO1994008657A1 (en) * 1992-10-20 1994-04-28 Noel Desmond Gray A heart pacemaker
DE4314269A1 (en) * 1993-04-30 1994-11-03 Georg Dr Berg Device for supporting the heart and/or for replacing myocardial power
US5954757A (en) * 1991-05-17 1999-09-21 Gray; Noel Desmond Heart pacemaker
US6044300A (en) * 1991-05-17 2000-03-28 Gray; Noel Desmond Heart pacemaker
WO2000072912A1 (en) * 1999-05-26 2000-12-07 Impulse Dynamics Nv Local cardiac motion control using applied electrical signals and mechanical force
US6304777B1 (en) 1999-05-26 2001-10-16 Impulse Dynamics N.V. Induction of cardioplegia applied electrical signals
US20020052632A1 (en) * 1996-01-08 2002-05-02 Shlomo Ben-Haim Electrical muscle controller
US6494825B1 (en) * 1998-04-22 2002-12-17 Scimed Life Systems, Inc. System for stress relieving the heart muscle and for controlling heart function
US20030040777A1 (en) * 1996-01-08 2003-02-27 Itzik Shemer Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue
US20030055464A1 (en) * 1999-03-05 2003-03-20 Nissim Darvish Blood glucose level control
US20030199955A1 (en) * 2002-04-22 2003-10-23 Chester Struble Cardiac restraint with electrode attachment sites
US20040243190A1 (en) * 1996-01-08 2004-12-02 Shlomo Ben-Haim Electrical muscle controller
US20040249421A1 (en) * 2000-09-13 2004-12-09 Impulse Dynamics Nv Blood glucose level control
US20050181504A1 (en) * 1999-02-04 2005-08-18 Technion Research & Development Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells
US7027863B1 (en) 1999-10-25 2006-04-11 Impulse Dynamics N.V. Device for cardiac therapy
US20060085045A1 (en) * 1999-03-05 2006-04-20 Metacure N.V. Blood glucose level control
US20060184207A1 (en) * 1999-03-05 2006-08-17 Metacure N.V. Blood glucose level control
US20060212079A1 (en) * 1999-10-25 2006-09-21 Routh Andre G Cardiac contractility modulation device having anti-arrhythmic capabilities and method of operating thereof
US20070027487A1 (en) * 2003-03-10 2007-02-01 Impulse Dynamics Nv Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue
US20070027493A1 (en) * 2003-07-21 2007-02-01 Shlomo Ben-Haim Gastrointestinal methods and apparatus for use in treating disorders and controlling blood sugar
US20070027490A1 (en) * 1996-09-16 2007-02-01 Shlomo Ben-Haim Fencing of Cardiac Muscles
US7236829B1 (en) * 2004-08-30 2007-06-26 Pacesetter, Inc. Implantable leadless cardiac device with flexible flaps for sensing
US20070171211A1 (en) * 2003-02-10 2007-07-26 N-Trig Ltd. Touch detection for a digitizer
US20070293901A1 (en) * 2004-03-10 2007-12-20 Impulse Dynamics Nv Protein activity modification
US20080037033A1 (en) * 2004-06-14 2008-02-14 Isra Vision Systems Ag Sensor For Measuring The Surface Of An Object
US7460907B1 (en) 1998-07-20 2008-12-02 Impulse Dynamics N.V. Pacing with hemodynamic enhancement
US20090062893A1 (en) * 2005-03-18 2009-03-05 Meta Cure Limited Pancreas lead
US20090088816A1 (en) * 1999-03-05 2009-04-02 Tami Harel Gastrointestinal Methods And Apparatus For Use In Treating Disorders And Controlling Blood Sugar
US20090292324A1 (en) * 2003-03-10 2009-11-26 Benny Rousso Protein activity modification
US20100016923A1 (en) * 2004-03-10 2010-01-21 Impulse Dynamics Nv Protein activity modification
US7840264B1 (en) 1996-08-19 2010-11-23 Mr3 Medical, Llc System and method for breaking reentry circuits by cooling cardiac tissue
US7908003B1 (en) 1996-08-19 2011-03-15 Mr3 Medical Llc System and method for treating ischemia by improving cardiac efficiency
US7953481B1 (en) 1999-10-25 2011-05-31 Impulse Dynamics N.V. Anti-arrhythmic device and a method of delivering anti-arrhythmic cardiac therapy
US8321013B2 (en) 1996-01-08 2012-11-27 Impulse Dynamics, N.V. Electrical muscle controller and pacing with hemodynamic enhancement
US8934975B2 (en) 2010-02-01 2015-01-13 Metacure Limited Gastrointestinal electrical therapy
US9101765B2 (en) 1999-03-05 2015-08-11 Metacure Limited Non-immediate effects of therapy
US9289618B1 (en) 1996-01-08 2016-03-22 Impulse Dynamics Nv Electrical muscle controller
US9713723B2 (en) 1996-01-11 2017-07-25 Impulse Dynamics Nv Signal delivery through the right ventricular septum
US9821158B2 (en) 2005-02-17 2017-11-21 Metacure Limited Non-immediate effects of therapy

Cited By (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3683933A (en) * 1970-06-22 1972-08-15 Peter B Mansfield Implantable tissue stimulator with a porous anchoring enclosure
US4030509A (en) * 1975-09-30 1977-06-21 Mieczyslaw Mirowski Implantable electrodes for accomplishing ventricular defibrillation and pacing and method of electrode implantation and utilization
US5058584A (en) * 1990-08-30 1991-10-22 Medtronic, Inc. Method and apparatus for epidural burst stimulation for angina pectoris
US5792208A (en) * 1991-05-17 1998-08-11 Gray; Noel Domond Heart pacemaker
US5954757A (en) * 1991-05-17 1999-09-21 Gray; Noel Desmond Heart pacemaker
US6044300A (en) * 1991-05-17 2000-03-28 Gray; Noel Desmond Heart pacemaker
WO1994008657A1 (en) * 1992-10-20 1994-04-28 Noel Desmond Gray A heart pacemaker
US5674259A (en) * 1992-10-20 1997-10-07 Gray; Noel Desmond Multi-focal leadless apical cardiac pacemaker
DE4314269A1 (en) * 1993-04-30 1994-11-03 Georg Dr Berg Device for supporting the heart and/or for replacing myocardial power
US8260416B2 (en) 1996-01-08 2012-09-04 Impulse Dynamics, N.V. Electrical muscle controller
US20070088393A1 (en) * 1996-01-08 2007-04-19 Shlomo Ben-Haim Electrical Muscle Controller
US20020052632A1 (en) * 1996-01-08 2002-05-02 Shlomo Ben-Haim Electrical muscle controller
US20080058879A1 (en) * 1996-01-08 2008-03-06 Shlomo Ben-Haim Electrical Muscle Controller
US20030040777A1 (en) * 1996-01-08 2003-02-27 Itzik Shemer Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue
US9289618B1 (en) 1996-01-08 2016-03-22 Impulse Dynamics Nv Electrical muscle controller
US8825152B2 (en) 1996-01-08 2014-09-02 Impulse Dynamics, N.V. Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue
US20040243190A1 (en) * 1996-01-08 2004-12-02 Shlomo Ben-Haim Electrical muscle controller
US8301247B2 (en) 1996-01-08 2012-10-30 Impulse Dynamics, N.V. Electrical muscle controller
US8321013B2 (en) 1996-01-08 2012-11-27 Impulse Dynamics, N.V. Electrical muscle controller and pacing with hemodynamic enhancement
US7167748B2 (en) 1996-01-08 2007-01-23 Impulse Dynamics Nv Electrical muscle controller
US8311629B2 (en) 1996-01-08 2012-11-13 Impulse Dynamics, N.V. Electrical muscle controller
US8306617B2 (en) 1996-01-08 2012-11-06 Impulse Dynamics N.V. Electrical muscle controller
US8306616B2 (en) 1996-01-08 2012-11-06 Impulse Dynamics, N.V. Electrical muscle controller
US7062318B2 (en) 1996-01-08 2006-06-13 Impulse Dynamics (Israel) Ltd Electrical muscle controller
US20070239216A9 (en) * 1996-01-08 2007-10-11 Itzik Shemer Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue
US9713723B2 (en) 1996-01-11 2017-07-25 Impulse Dynamics Nv Signal delivery through the right ventricular septum
US7840264B1 (en) 1996-08-19 2010-11-23 Mr3 Medical, Llc System and method for breaking reentry circuits by cooling cardiac tissue
US7908003B1 (en) 1996-08-19 2011-03-15 Mr3 Medical Llc System and method for treating ischemia by improving cardiac efficiency
US20070027490A1 (en) * 1996-09-16 2007-02-01 Shlomo Ben-Haim Fencing of Cardiac Muscles
US6494825B1 (en) * 1998-04-22 2002-12-17 Scimed Life Systems, Inc. System for stress relieving the heart muscle and for controlling heart function
US7460907B1 (en) 1998-07-20 2008-12-02 Impulse Dynamics N.V. Pacing with hemodynamic enhancement
US7678573B2 (en) 1999-02-04 2010-03-16 Pluristem Ltd. Method of preparing a conditioned medium from a confluent stromal cell culture
US20050180958A1 (en) * 1999-02-04 2005-08-18 Technion Research & Development Foundation Ltd. Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells
US20050181504A1 (en) * 1999-02-04 2005-08-18 Technion Research & Development Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells
US8019421B2 (en) 1999-03-05 2011-09-13 Metacure Limited Blood glucose level control
US20030055464A1 (en) * 1999-03-05 2003-03-20 Nissim Darvish Blood glucose level control
US9101765B2 (en) 1999-03-05 2015-08-11 Metacure Limited Non-immediate effects of therapy
US8700161B2 (en) 1999-03-05 2014-04-15 Metacure Limited Blood glucose level control
US8346363B2 (en) 1999-03-05 2013-01-01 Metacure Limited Blood glucose level control
US20060085045A1 (en) * 1999-03-05 2006-04-20 Metacure N.V. Blood glucose level control
US20090088816A1 (en) * 1999-03-05 2009-04-02 Tami Harel Gastrointestinal Methods And Apparatus For Use In Treating Disorders And Controlling Blood Sugar
US20060184207A1 (en) * 1999-03-05 2006-08-17 Metacure N.V. Blood glucose level control
US8666495B2 (en) 1999-03-05 2014-03-04 Metacure Limited Gastrointestinal methods and apparatus for use in treating disorders and controlling blood sugar
US6304777B1 (en) 1999-05-26 2001-10-16 Impulse Dynamics N.V. Induction of cardioplegia applied electrical signals
WO2000072912A1 (en) * 1999-05-26 2000-12-07 Impulse Dynamics Nv Local cardiac motion control using applied electrical signals and mechanical force
US6973347B1 (en) * 1999-05-26 2005-12-06 Impulse Dynamics Nv Local cardiac motion control using applied electrical signals and mechanical force
US7027863B1 (en) 1999-10-25 2006-04-11 Impulse Dynamics N.V. Device for cardiac therapy
US7647102B2 (en) 1999-10-25 2010-01-12 Impulse Dynamics N.V. Cardiac contractility modulation device having anti-arrhythmic capabilities and method of operating thereof
US7953481B1 (en) 1999-10-25 2011-05-31 Impulse Dynamics N.V. Anti-arrhythmic device and a method of delivering anti-arrhythmic cardiac therapy
US20060212079A1 (en) * 1999-10-25 2006-09-21 Routh Andre G Cardiac contractility modulation device having anti-arrhythmic capabilities and method of operating thereof
US20040249421A1 (en) * 2000-09-13 2004-12-09 Impulse Dynamics Nv Blood glucose level control
US7181272B2 (en) * 2002-04-22 2007-02-20 Medtronic, Inc. Cardiac restraint with electrode attachment sites
US20030199955A1 (en) * 2002-04-22 2003-10-23 Chester Struble Cardiac restraint with electrode attachment sites
US8228311B2 (en) 2003-02-10 2012-07-24 N-Trig Ltd. Touch detection for a digitizer
US7843439B2 (en) 2003-02-10 2010-11-30 N-Trig Ltd. Touch detection for a digitizer
US20070171211A1 (en) * 2003-02-10 2007-07-26 N-Trig Ltd. Touch detection for a digitizer
US7840262B2 (en) 2003-03-10 2010-11-23 Impulse Dynamics Nv Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue
US9931503B2 (en) 2003-03-10 2018-04-03 Impulse Dynamics Nv Protein activity modification
US20090292324A1 (en) * 2003-03-10 2009-11-26 Benny Rousso Protein activity modification
US20070027487A1 (en) * 2003-03-10 2007-02-01 Impulse Dynamics Nv Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue
US8326416B2 (en) 2003-03-10 2012-12-04 Impulse Dynamics Nv Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue
US20110093028A1 (en) * 2003-03-10 2011-04-21 Impulse Dynamics Nv Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue
US20070027493A1 (en) * 2003-07-21 2007-02-01 Shlomo Ben-Haim Gastrointestinal methods and apparatus for use in treating disorders and controlling blood sugar
US8792985B2 (en) 2003-07-21 2014-07-29 Metacure Limited Gastrointestinal methods and apparatus for use in treating disorders and controlling blood sugar
US20070293901A1 (en) * 2004-03-10 2007-12-20 Impulse Dynamics Nv Protein activity modification
US20100016923A1 (en) * 2004-03-10 2010-01-21 Impulse Dynamics Nv Protein activity modification
US8548583B2 (en) 2004-03-10 2013-10-01 Impulse Dynamics Nv Protein activity modification
US8352031B2 (en) 2004-03-10 2013-01-08 Impulse Dynamics Nv Protein activity modification
US20080037033A1 (en) * 2004-06-14 2008-02-14 Isra Vision Systems Ag Sensor For Measuring The Surface Of An Object
US7236829B1 (en) * 2004-08-30 2007-06-26 Pacesetter, Inc. Implantable leadless cardiac device with flexible flaps for sensing
US9821158B2 (en) 2005-02-17 2017-11-21 Metacure Limited Non-immediate effects of therapy
US8244371B2 (en) 2005-03-18 2012-08-14 Metacure Limited Pancreas lead
US20090062893A1 (en) * 2005-03-18 2009-03-05 Meta Cure Limited Pancreas lead
US8934975B2 (en) 2010-02-01 2015-01-13 Metacure Limited Gastrointestinal electrical therapy

Also Published As

Publication number Publication date
BE728990A (en) 1969-08-26
FR94491E (en) 1969-08-22
DE1906478A1 (en) 1969-09-18
NL6902877A (en) 1969-09-01
DE1906478B2 (en) 1977-05-18
GB1231121A (en) 1971-05-12

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AS Assignment

Owner name: HONEYWELL B.V. AMSTERDAM, HOLLAND A SUBSIDIARY OF

Free format text: ASSIGNOR ASSIGNS THE ENTIRE INTEREST, SUBJECT TO LICENSE RECITED.;ASSIGNOR:U.S. PHILIPS CORPORATION;REEL/FRAME:003979/0375

Effective date: 19820305