US3570486A - Mixing syringe - Google Patents

Mixing syringe Download PDF

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Publication number
US3570486A
US3570486A US3570486DA US3570486A US 3570486 A US3570486 A US 3570486A US 3570486D A US3570486D A US 3570486DA US 3570486 A US3570486 A US 3570486A
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Prior art keywords
means
portion
end
piston
conduit
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Harvey J Engelsher
Peter C Hofstra
Robert W Mckirdy
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HORIZON IND Ltd
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HORIZON IND Ltd
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
    • B01F15/00Accessories for mixers ; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F15/02Feed or discharge mechanisms
    • B01F15/0201Feed mechanisms
    • B01F15/0205Feed mechanisms comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartiments or cartridges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2422Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/2429Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by telescoping of ampoules or carpules with the syringe body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
    • B01F11/00Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F11/008Mixers with shaking, oscillating, or vibrating mechanisms the stirrers performing an oscillatory, vibratory or shaking movement
    • B01F11/0082Mixers with shaking, oscillating, or vibrating mechanisms the stirrers performing an oscillatory, vibratory or shaking movement performing a rectilinear reciprocating movement
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
    • B01F13/00Other mixers; Mixing plant, including combinations of mixers, e.g. of dissimilar mixers
    • B01F13/0016Movable or transportable mixing devices or plants
    • B01F13/0018Movable mixing devices, i.e. apt to be shifted or displaced from one place to another, e.g. by human force
    • B01F13/002Movable mixing devices, i.e. apt to be shifted or displaced from one place to another, e.g. by human force portable during use, e.g. hand-held
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
    • B01F13/00Other mixers; Mixing plant, including combinations of mixers, e.g. of dissimilar mixers
    • B01F13/0016Movable or transportable mixing devices or plants
    • B01F13/0018Movable mixing devices, i.e. apt to be shifted or displaced from one place to another, e.g. by human force
    • B01F13/002Movable mixing devices, i.e. apt to be shifted or displaced from one place to another, e.g. by human force portable during use, e.g. hand-held
    • B01F13/0023Of the syringe, cartridge type
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
    • B01F15/00Accessories for mixers ; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F15/02Feed or discharge mechanisms
    • B01F15/0201Feed mechanisms
    • B01F15/0205Feed mechanisms comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartiments or cartridges
    • B01F15/0212Piercing, perforating, melting membranes, closures which seal the compartments
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
    • B01F15/00Accessories for mixers ; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F15/02Feed or discharge mechanisms
    • B01F15/0201Feed mechanisms
    • B01F15/0222Feed mechanisms characterized by the relative arrangement of the containers for feeding or mixing the components
    • B01F15/0225Feed mechanisms characterized by the relative arrangement of the containers for feeding or mixing the components the containers being connected in a mouth-to-mouth, end-to-end disposition, i.e. the openings are juxtaposed before contacting the contents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • A61M2005/31598Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing having multiple telescopically sliding coaxial pistons encompassing volumes for components to be mixed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2422Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/2425Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
    • B01F15/00Accessories for mixers ; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F15/00435Drives, e.g. for reciprocating motion; Transmissions; Brakes; Couplings
    • B01F15/00487Nature of the drive
    • B01F15/00506Hand driven

Abstract

A mixing syringe assembly which maintains the respective constituents of a composition in separate chambers, and which includes a shuttle assembly for interconnecting the chambers for mixing the respective constituents therein prior to use.

Description

United States Patent [72] Inventors HarveyJ.Engelsher Yonkers, N.Y.; Peter C. Hofstra, Paterson, N.J.; Robert W. McKirdy, Scarsdale, N.Y. [21] Appl. No. 767,262 [22] Filed Oct. 14, 1968 [45] Patented Mar. 16, 1971 [73] Assignee Horizon Industries, Ltd.

New York, N.Y.

[54] MIXING SYRINGE 10 Claims, 8 Drawing Figs.

[52] U.S. C1 128/218 [51] Int. Cl A6lm 5/22 [50] Field ofSearch 128/215, 216, 218 (P), 218 (PA), 218.1, 218.1 (P), 218.2; 128/218, 218 (M), 220, 272

[56] References Cited UNITED STATES PATENTS 1,557,836 10/1925 Hein 128/220 Primary Examiner-Joseph S. Reich Attorney- Irving Seidman ABSTRACT: A mixing syringe assembly which maintains the respective constituents of a composition in separate chambers, and which includes a shuttle assembly for interconnecting the chambers for mixing the respective constituents therein prior to use.

MIXING sYRINcs BACKGROUND or THE INVENTION I.Field of the Invention This invention relates generally to a mixing syringe, and more particularly, to a device for mixing amedicament' with a suitable diluent to form a mixture suitable for'injection.-

2. Description of the Prior Art Many drugs: and medicinal products are subject to deterioration unless they are manufactured in dry powder form, and which are brought into solution or into suspension in a suitable diluent immediately prior to use; For example, certain antibiotics, vitamins and hormones do not retain their properties when packaged -in' solution form. Manufacturers of such products have therefore been required to market the powder and the diluent in separate flasks, ampuls or other receptacles, whereupon therespective constituents are subsequently mixed together in a bottle. The 'composition or mixture is then drawn into a syringe and administered as soon as possible to the patient, oris added to some othenparenteral solution for immediate use. It is readily appar'entth'at the use of separate flasks orampuls increases the manufacturing cost. of j the product, increases the possibility of spilling the constituents during the mixing operation" and increase the possibilityof contamination of such constituents during the mixing operation and during the subsequent transferring operation of same tothesyringe j v In thisiconnection', the;mixing of certain products must be performed with extreme cautiomFor example, the mixing of nitrogen mustard, whichis used in cancer therapy, is. an ,extremely dangerous operation causing'severecaustic burns if brought accidentally into contact with the skin.

In an .attempLto overcome some of the problems and hazards referredto above, there has been proposed various syringe assemblies formed of ,a.plurali ty of compartments, A

medicament is disposed in one of thecompartments anda.

diluent is disposed in another one of said compartments, whereby the respective. substances are mixed together immediately prior to use. The major difficulty and disadvantage. of such known syringe assemblies reside in the mixing operation of the respective substances therein. In this connection, it has been found that the known syringe assemblies do not provide sufficient or adequate means for effectively and efficiently mixing the respective substances prior to use.

The present invention overcomes the above difficulties and disadvantages by providing a mixing syringe which maintains the respective substances in separate compartments, and which includes novel shuttle means for quickly and effectively mixing said substances in a manner hereinafter described.

SUMMARY or THE INVENTION plunger. for carrying selective constituents of. a composition;

said barrel and plunger each having a piston. reciprocably. mounted therein for defining the respective chambers. A mixing shuttle is provided having conduitmeans mounted thereon for conjoint movement. therewith. The :barrel; plunger and mixing shuttle are connected together whereby the opposite end portions of the conduit means 'are respectivelyconnected to the barrel piston and the plunger piston for conjoint movement therewith. The end portions of the conduit means have terminal ends respectively penetrating the pistons for establishing communicationbetween the respective chambers via said conduit means for mixing the respective constituents therein in. response to the reciprocabie and conjoint movement of the shuttle means and the pistons relative to the barrel and the plunger. I g

In another embodiment of the invention, the plunger is replaced with an expansible chamber for carrying a selected constituent of the composition; said chamber having a forward wall portion connected to a conduit end portion for conjoint movement therewith. In this embodiment,. -the.end portionsof the conduit means have terminal ends respectively penetrating the barrel piston andthe expansible chamber for establishing communication between the respective chambers via. said conduit means for mixing the respective constituents therein in response to the reciprocable movement of the shuttle means and the expansion and contraction of the expansible chamber.

Suitable outlet means are provided on the barrel for dispensing the mixture oncomposition therefrom.

Accordingly, an object of the present invention is to provide a mixing syringe for mixing a dry powdered medicinal substancewith a suitable diluent to form a mixture suitable for injection, andto provide a device by which the mixing and the injection can be effected successively.

The above and other objects, features and advantages of the present invention will become more apparent from a consideration of the following detailed description when taken in conjunction with the accompanying drawings.

BRI F DESCRIPTION or TasuR/twmos FIG. 1 is a side elevationalview, with parts in section and parts broken away, of the mixing syringe assembly constructed in accordance with the present invention;- 1

' FIG. 2 is a'view similar to FIG. 1 illustrating the component parts coupled together;

FIG. 3 is a view similar to FIG. 2 illustrating one position of the mixing syringe assembly'during the mixing operation; and

FIG. 8 is a view similar to FIG. 7 illustrating the mixing syringe in position for dispensing the composition therefrom.

DESCRIPTION OF THE PREFERRED EMBODIMENTS Referring to the drawings, and more particularly to FIGS. 1 through 4, numeral 10, represents the mixing syringe constructed in accordance withthe present invention. Syringe 10 includes a barrel 1 2 formed of glass, plastic or other suitable material. In accordance with conventional construction, barrel 12 is provided with a tubular wall 14 and a transversely extending front wall.l6 from which a tip or nosepiece I8 projects outwardly and serves as a dispensing outlet. ln'this connection, nosepiece 18 isprovided with a bore 20 establishing communication between the interior of barrel 1 2 and nosepiece 1 8. Cap 22 is separably mounted on nosepiece 18.

by suitable fastening means, indicated generally bynumeral 24;, and serves as a closure for the barrel dispensing outlet dun.

ing the mixing operation. At such time as the mixture or composition is to be dispensed from the barrel outlet, cap 22 is removed and replaced with a conventional hypodermic needle in a manner'hereinafter described. The rear end portion of tubular wall I4 is open and is. provided with a transversely extending flange portion 26 projecting outwardly and serving as finger gripping portions for barrel l2.

Reciprocably mounted within the open end of barrel 12 is a piston 28 formed of a flexible, resilient and penetrable materi-,

al such as rubber or the like. Piston 28 constitutes a cylindrical plug or seal and serves to define a forward chamber30 in barrel L2 for carrying one constituent of a composition.

Piston 28includes a conical shape cavity portion 32 formed axially therein and which is tapered toward the front end 5mg, face 34 thereof to provide wall portion 36 having a reduced" thickness betweenlhe bottom or apex of cavity 32 and the frontend surface 34 of piston 28, at the axis thereof. The rear, end surface 38 o f piston Zfi definesan annular flange 40 ing a centrally provided opening 42 therein affording access to cavity portion 32. The. construction is such as top ermit piston 28 to be separably connected to a mixing shuttle of the syringe assembly.

Mixing shuttle 44 is provided with a tubular wall 46 reciprocably mounted through the open end of barrel l2 and located rearwardly of piston 28. Shuttle 44 may be formed of glass, plastic or other suitable material. Tubular wall 46 includes a transversely extending flange portion 48 projecting outwardly from the rear end thereof and serving as finger gripping portions for shuttle 44. Tubular wall 46 further includes a transversely extending wall portion 50 projecting radially inwardly from the forward end thereof and to which is fixedly secured conduit means 52 extending axially of tubular wall 46; said conduit 52 having a bore 54 extending longitudinally the length thereof. The construction is such that conduit 52 moves conjointly with the reciprocable movement of shuttle 44.

The end portions 56 and 58 of conduit 52 are provided with head portions 60 and 62 respectively, for interconnecting various components of the syringe assembly. In this connection, head portion 60 has a surface configuration complementary to the taper of cavity 32 in piston 28, and includes a tapered terminal end 64 projecting forwardly therefrom. The construction is such that the axis of terminal end 64 is coincident with the axis of piston 28 for subsequently piercing wall portion 36 of piston 28. Accordingly, head portion 60 and terminal end 64, together with piston cavity 32 and piston flange 40, provide coacting means for interengaging the end portion 56 of conduit 52 with piston 28 upon slidable movement of conduit 52 relative to said piston. Head portion 62 similarly includes a tapered terminal end 66 for interconnecting the end portion 58 of conduit 52 to a plunger component of the syringe assembly.

Reciprocably mounted within shuttle 44 is a plunger assembly indicated generally by the numeral 68. Plunger 68 may be formed of glass, plastic or other suitable material, and includes a tubular wall 70 telescopically disposed within shuttle 44. Tubular wall 70 is closed at the rear end 72 thereof and may be provided with a transversely extending flange portion 74 projecting radially outwardly therefrom and serving as finger gripping portions for plunger 68. Tubular wall 70 further includes another transversely extending flange portion 76 projecting radially inwardly from the forward end thereof. Reciprocably mounted within plunger 68 is a piston 78 formed of a flexible, resilient and penetrable material such as rubber or the like. Piston 78 is suitably sized to constitute a cylindrical plug or seal for defining a rearward chamber 80 in plunger 68 for carrying another constituent of the composition. In this connection, piston 78 is similar in construction to piston 28, and includes a conical shape cavity portion 82 formed axially therein and which is tapered toward the rear end surface 84 thereof. Accordingly, there is provided a piston wall portion 86 having a reduced thickness between the bottom or apex of cavity 82 and the rear end surface 84 of piston 78, at the axis thereof. The forward end surface 88 of piston 78 defines as annular flange 90 having a centrally provided opening 92 therein affording access to cavity portion 82.

Referring again to mixing shuttle 44, the head portion 62 of conduit end portion 58 is provided with a surface configuration complementary to the taper ofcavity 82 in piston 78. The construction is such that the axis of terminal end 66 of head portion 62 is coincident with the axis of piston 78 for subsequently piercing wall portion 86 of piston 78. It is now apparent that head portion 62 and terminal end 66, together with piston cavity 82 and piston flange 90, provide coacting means for interengaging the end portion 58 of conduit 52 with piston 78 upon slidable movement of conduit 52 relative to said piston.

Having described the component parts of the novel mixing syringe of the present invention, attention is now directed to the operation thereof as embodied in FIGS. 1 through 4. Chambers 30 and 80, located in barrel 12 and plunger 68 respectively, are illustrated as carrying the constituents of the composition. It will be appreciated that while chamber 80 is illustrated as carrying the dry powder medicament and chamber 30 carrying the suitable diluent, the location of the respective constituents with respect to said chambers can be reversed. Furthermore, it is readily apparent that the syringe of the present invention can be used for mixing medicinal products which do not include a powder constituent. In those situations where one of the constituents is in powder form, it is preferable to connect the mixing shuttle to the chamber carrying the dry constituent prior to connecting the mixing shuttle to the chamber carrying the diluent.

Accordingly, shuttle 44 and plunger 68 are slidably moved relative to one another for interengaging conduit end portion 58 with piston 78, whereby piston cavity 82 receives the head portion 62 of conduit 52. The arrangement is such that terminal end 66 of conduit 52 pierces piston wall portion 86 for establishing communication between chamber and the bore 54 of conduit 52. The sealing arrangement of piston 78 relative to plunger wall 70, and the thickness of piston wall portion 86, are such that coupling of conduit end portion 58 with piston 78 is readily achieved without materially displacing the piston within plunger wall 70; whereupon piston 78 will thereafter move conjointly with conduit end portion 58. Mixing shuttle 44 is then connected to chamber 30 by slidably moving shuttle 44 and barrel 12 relative to one another for interengaging conduit end portion 56 with piston 28. The coupling arrangement is similar to that described with respect to chamber 80 whereby piston cavity 32 receives the head portion 60 of conduit 52, and terminal end 64 of conduit 52 pierces piston wall portion 36 for establishing communication between chamber 30 and the bore 54 of conduit 52. It will be noted that during the coupling operations described above, the piston flanges 40 and 9,0 ofpistons 28 and 78 respectively, must be sufficiently resilient so as to be initially displaced within the respective piston cavities 32 and 82 and thereafter reassume their normal positions whereby said flanges 40 and will abut against the respective shoulders of conduit head portions 60 and 62. In this connection, FIG. 1 illustrates in phantom conduit end portion 56 after it has been slidably moved within barrel 12 a distance sufficient to permit piston flange 40 to reassume its normal position. It is now apparent that communication is established between chambers 30 and 80 via bore 54 of conduit 52 for mixing the respective constituents of the composition therein in response to the reciprocable and conjoint movement of shuttle 44 and pistons 28 and 78 relative to barrel 12 and plunger 68. In other words, when barrel l2 and plunger 68 are fixedly held in the position illustrated in FIG. 3, forward movement of shuttle 44 will force the diluent in chamber 30 through the bore 54 of conduit 52 and into contact with the powder medicament in chamber 80. Thereafter, retracted movement of shuttle 44 will force the mixed constituents from chamber 80 to chamber 30 via conduit 52. Further reciprocable movement of shuttle 44 will transfer the mixed constituents alternately between the respective chambers for quickly and effectively mixing said constituents prior to use. Flange portion 76 of plunger 68 serves as a stop to prevent piston 78 from being inadvertently withdrawn from plunger 68 during the mixing operation. After the constituents have been sufficiently mixed, shuttle 44 is positioned to locate the mixture or composition in chamber 80. Barrel closure cap 22 may now be removed for mounting the hub 94 of hypodermic needle 96 on barrel nose piece 18 in a conventional manner. Mixing shuttle 44 can now be positioned to locate the composition in chamber 30, as shown in FIG. 4, whereby the composition will be dispensed from the barrel outlet and through hypodermic needle 96 in response to the combined forward movement of plunger 68 and shuttle 44 relative to barrel 12.

FIGS. 5 through 8 represent another embodiment of a mixing syringe 100 constructed in accordance with the present invention wherein plunger 68 is replaced with an expansiblc chamber for carrying a selected constituent of the composition. In this connection, the structural details of the respective syringes l0 and 100 are essentially similar to one another, and accordingly, those details of syringe 100 common to syringe carry similar reference numerals designated with a prime notation; said common details and components operating and functioning in a similar manner so that a detailed description of same is not deemed necessary.

Expansible chamber 110 has a forward wall portion 112 slidably mounted within shuttle M'and an axially extensible wall portion 114 extending rearwardly thereof which is closed by rear wall portion 116. Expansible chamber 110 may be formed of a flexible, resilient material such as rubber, plastic or the like, and constitutes a bellows which defines chamber 118 for carrying the powder medicament. In the preferred construction, forward wall portion 112 is formed of a penetrable material, such as rubber, and includes a conical shape cavity portion 120 formed axially therein and which is tapered toward the rear end surface 122 thereof. Accordingly, there is provided a wall portion 124 having a reduced thickness between the bottom or apex of cavity 120 and the rear end surface 122, at the axis thereof. The forward end surface 126 of forward wall portion 112 defines an annular flange 128 having a centrally provided opening 130 therein affording access to cavity portion 120.

Referring to mixing shuttle 44'the head portion 62'of conduit end portion 58' is provided with a surface configuration complementary to the taper of cavity 120 in forward wall portion 112. The construction is such that the axis of terminal end 66' of head portion 62 is coincident with the axis of expansible chamber 110 for subsequently piercing wall portion 124 of forward wall portion 112. It is now apparent that head portion 62' arid terminal end 66', together with forward wall cavity 120 and forward wall flange 128,.provide coacting means for interengaging the end portion 58with the forward wall portion 112 of expansible chamber 110, and piercing wall portion 124 upon slidable movement of forward wall portion 112 relative to conduit 52.

in operation, shuttle 44' and the forward wall portion 112 of expansible chamber 110 are slidably moved relative to one another for interengaging conduit end portion 58' with forward wall portion 112, whereby forward wall cavity 120 receives the head portion 62' of conduit 52'. The arrangement is such that terminal end 66' of conduit 52' pierces wall portion 124 for establishing communication between chamber 118 and the bore 54' of conduit 52. The coupling operation is similar to that described with respect to the embodiment of FIGS. 1 through 4 whereby the forward wall portion 112 of expansible chamber 110 will thereafter move conjointly with conduit 0 PORTION 58' Mixing shuttle 44 is then connected to chamber 30 by slidably moving shuttle 44' and barrel 12' relative to one another for interengaging conduit end portion 56' with piston 28' in the manner heretofore described. It is now apparent that communication is established between chambers 30' and 118 via bore 54 of conduit 52' for mixing the respective constituents of the composition therein in response to the reciprocable movement of shuttle 44' and the expansion and contraction of expansible chamber 110. In other words, piston 28' and the forward wall portion 112 of expansible chamber 110 are coupled to conduit end portions 56' and 58' respectively, for conjoint movement therewith. Forward movement of shuttle 14' relative to barrel 12', as shown in FIG. 7, will force the diluent in chamber 30' through the bore 54' of conduit 52' and into contact with the powder medicament in chamber 118 thereby expanding expansible chamber 110. Thereafter, retracted movement of shuttle 44 relative to barrel 12 will reduce the pressure in chamber 30' and thus serve to transfer the mixed constituents from chamber 11% to chamber 30', via conduit 52', thereby contracting expansible chamber 110. Furtherreciprocable movement of shuttle 44' will transfer the mixed constituents alternately between the respective chambers for quickly and effectively mixing said constituents prior to use. The dispensing operation is performed similarly to that described with respect to the embodiment of FlGS. 1 through 4, whereby shuttle 44' is positioned to locate the mixture or composition in chamber 118. Barrel closure cap 22' may now be removed for mounting the hub 94 of hypodermic needle 96 on barrel nose piece 18. Mixing shuttle 44 is then positioned to locate the composition in chamber 30', as shown in H6. 8, whereby the composition will be dispensed from the barrel outlet and through hypodermic needle 96 in response to the combined forward movement of expansible camber and shuttle 44 relative to barrel 12'.

Accrodingly, there is now provided a mixing syringe assembly which maintains the respective constituents in separate compartments and which includes a shuttle assembly for interconnecting the compartments for quickly and effectively mixing the constituents prior to use. Plunger 68 and expansible chamber 110, respectively containing selected constituents, can be manufactured, supplied and stored separately for selective use and coupling with the mixing syringe as required. Furthermore, whereas the forward wall portion 112 of expansible chamber 110 is preferably illustrated as being slidably mounted within shuttle 44', this construction is merely illustrative and is not to be deemed a limitation on the invention. For example, the embodiment of FIGS. 5 through 8 can be readily constructed with conduit end portion 58' extending beyond the open end ofshuttle 44' and being connected to the forward wall portion 112 of expansible chamber 110 in the manner heretofore described, without otherwise altering the mixing and dispensin operation. if desired, the mixed constituents can be added to some other parenteral solution for immediate use.

While specific embodiments of the invention have been shown and described in detail, it will be readily understood and appreciated that various changes or modifications thereof may be made without departing from the spirit and scope of the invention as set forth in the appended claims.

We claim: 1

1. A string for mixing the constituents of a given composition and dispensing the same comprising:

a. a barrel having a dispensing outlet at a forward end thereof and being open at the rear end thereof;

b. closure means separably mounted on the outlet end of the barrel;

c. piston means reciprocably mounted within the barrel and defining a chamber forwardly thereof for containing one constituent of the composition;

. shuttle means mounted within the barrel for reciprocable movement therein;

e. movable chamber means in said piston means for containing another constituent of the composition;

f. said shuttle means including conduit means arranged for conjoint movement therewith;

g. said conduit means having one end portion engaged with and projecting through a wall portion of the movable chamber means; and

h. the other end portion the said conduit means being engaged with and projecting through the piston means whereby said conduit means is in communication between the first and second mentioned chambers via said conduit means for alternately and forcibly reversing the flow of the constituents of the composition between said chambers for mixing said constituents in response to selective reciprocal movement of the shuttle means relative to the barrel and he movable chamber means; and whereby the composition may be dispensed from the barrel outlet upon removal of the closure means therefrom and in response to the combined forward movement of the shuttle means and the movable chamber means relative to the barrel.

2. A string as recited in claim 1, wherein said shuttle means comprises a tubular member reciprocably mounted within the barrel, said tubular member including a transverse wall portion; said conduit means extending axially of the tubular member and being fixed to the transverse wall portion and said other end portion of said conduit means extending through and projecting beyond said transverse wall portion.

3. The syringe as recited in claim 1 wherein said movable chamber means comprises a hollow plunger closed at the rear end thereof and being open at the forward end thereof; second piston means reciprocably mounted within the plunger for defining a chamber rearwardly thereof for containing said other constituent of the composition; said plunger being mounted within the shuttle means for reciprocable movement therewith.

4. A syringe as recited in claim 3, wherein said plunger includes stop means engageable with the second piston means for limiting the rearward movement of said plunger relative to the shuttle means.

5. A syringe as recited in claim 3, further comprising coacting means on each of the first and second piston means and the opposite end portions of said conduit means for interlocking the pistons with the respective end portions of said conduit means and connecting said pistons to said conduit means for conjoint movement therewith, whereby the terminal ends of said end portions respectively penetrate a wall portion of its associated piston means.

6. A syringe as recited in claim 5, wherein said coacting means comprise enlarged head portions on the opposite end portions of said conduit means; said coacting means of said first and second piston means including cavity means for respectively receiving the head portions of said conduit means.

7. A syringe as recited in claim 6, wherein the cavity means in each piston means is formed in one end surface thereof and is tapered toward the other end surface thereof to thereby provide a portion of relatively reduced thickness of said piston between the forward portion of said cavity means and the other end surface of said piston at the axis thereof; each of the head portions of said conduit means having a surface portion complementary to the taper of the cavity portion of the associated piston means; the conduit means also having terminal ends projecting beyond said head portions; and the axes of said terminal ends being respectively coincident with the axes of said first and second piston means.

8. A syringe as recited in claim 1, wherein said shuttle means has a relatively nlargd end portion and said movable chamber means is expansible and includes a forward wall portion and an axially extensible wall portion extending therefrom; the forward wall portion of said expansible chamber means being slidably mounted within the relatively enlarged end portion of said shuttle means.

9. A syringe as recited in claim 8, further comprising coacting means on the rear end portion of the conduit means and the forward wall portion of the expansible chamber for interlocking the conduit means with the forward wall portion of the expansible chamber and extending rearwardly beyond said forward wall portion.

10. A syringe as recited in claim 9, further comprising coacting means on the forward end portion of the conduit means and the piston means for interlocking the conduit means with the piston means extending forwardly beyond said piston means.

Claims (10)

1. A syringe for mixing the constituents of a given composition and dispensing the same comprising: a. a barrel having a dispensing outlet at a forward end thereof and being open at the rear end thereof; b. closure means separably mounted on the outlet end of the barrel; c. piston means reciprocably mounted within the barrel and defining a chamber forwardly thereof for containing one constituent of the composition; d. shuttle means mounted within the barrel for reciprocable movement therein; e. movable chamber means in said piston means for containing another constituent of the composition; f. said shuttle means including conduit means arranged for conjoint movement therewith; g. said conduit means having one end portion engaged with and projecting through a wall portion of the movable chamber means; and h. the other end portion the said conduit means being engaged with and projecting through the piston means; whereby said conduit means is in communication between the first and second mentioned chambers via said conduit means for alternately and forcibly reversing the flow of the constituents of the composition between said chambers for mixing said constituents in response to selective reciprocal movement of the shuttle means relative to the barrel and the movable chamber means; and whereby the composition may be dispensed from the barrel outlet upon removal of the closure means therefrom and in response to the combined forward movement of the shuttle means and the movable chamber means relative to the barrel.
2. A syringe as recited in claim 1, wherein said shuttle means comprises a tubular member reciprocably mounted within the barrel, said tubular member including a transverse wall portion; said conduit means extending axially of the tubular member and being fixed to the transverse wall portion and said other end portion of said conduit means extending through and projecting beyond said transverse wall portion.
3. The syringe as recited in claim 1 wherein said movable chamber means comprises a hollow plunger closed at the rear end thereof and being open at the forward end thereof; second piston means reciprocably mounted within the plunger for defining a chamber rearwardly thereof for containing said other constituent of the composition; said plunger being mounted within the shuttle means for reciprocable movement therewith.
4. A syringe as recited in claim 3, wherein said plunger includes stop means engageable with the second piston means for limiting the rearward movement of said plunger relative to the shuttle means.
5. A syringe as recited in claim 3, further comprising coacting means on each of the first and second piston means and the opposite end portions of said conduit means for interlocking the pistons with the respective end portions of said conduit means and connecting said pistons to said conduit means for conjoint movement therewith, whereby the terminal ends of said end portions respectively penetrate a wall portion of its associated piston means.
6. A syringe as recited in claim 5, wherein said coacting means comprise enlarged head portions on the opposite end portions of said conduit means; said coacting means of said first and second piston means including cavity means for respectively receiving the head portions of said conduit means.
7. A syringe as recited in claim 6, wherein the cavity means in each piston means is formed in one end surface thereof and is tapered toward the other end surface thereof to thereby provide a portion of relatively reduced thickness of said piston between the forward portion of said cavity means and the other end surface of said piston at the axis thereof; each of the head portions of said conduit means having a surface portion complementary to the taper of the cavity portion of the associated piston means; the conduit means also havIng terminal ends projecting beyond said head portions; and the axes of said terminal ends being respectively coincident with the axes of said first and second piston means.
8. A syringe as recited in claim 1, wherein said shuttle means has a relatively enlarged end portion and said movable chamber means is expansible and includes a forward wall portion and an axially extensible wall portion extending therefrom; the forward wall portion of said expansible chamber means being slidably mounted within the relatively enlarged end portion of said shuttle means.
9. A syringe as recited in claim 8, further comprising coacting means on the rear end portion of the conduit means and the forward wall portion of the expansible chamber for interlocking the conduit means with the forward wall portion of the expansible chamber and extending rearwardly beyond said forward wall portion.
10. A syringe as recited in claim 9, further comprising coacting means on the forward end portion of the conduit means and the piston means for interlocking the conduit means with the piston means extending forwardly beyond said piston means.
US3570486A 1968-10-14 1968-10-14 Mixing syringe Expired - Lifetime US3570486A (en)

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US4036225A (en) * 1974-09-19 1977-07-19 Maury Jean Robert Bicompartmental syringe
US4059109A (en) * 1976-07-27 1977-11-22 Tischlinger Edward A Mixing and dispensing disposable medicament injector
US4066067A (en) * 1975-03-21 1978-01-03 Dematex Development & Investment Establishment Vial stopper for blood sampling device
FR2400368A1 (en) * 1977-08-15 1979-03-16 Abbott Lab Prefilled syringe has two compartments
US4188949A (en) * 1977-07-05 1980-02-19 Becton, Dickinson & Company Sequential injection syringe
US4781679A (en) * 1986-06-12 1988-11-01 Abbott Laboratories Container system with integral second substance storing and dispensing means
US4808184A (en) * 1985-05-14 1989-02-28 Laboratorium Fur Experimentelle Chirurgie Forschungsinstitut Method and apparatus for preparing a self-curing two component powder/liquid cement
US4886495A (en) * 1987-07-08 1989-12-12 Duoject Medical Systems Inc. Vial-based prefilled syringe system for one or two component medicaments
US4994029A (en) * 1989-09-12 1991-02-19 David Bull Laboratories Pty. Ltd. Syringe mixer and injector device
US5171214A (en) * 1990-12-26 1992-12-15 Abbott Laboratories Drug storage and delivery system
US5364369A (en) * 1987-07-08 1994-11-15 Reynolds David L Syringe
FR2705240A1 (en) * 1993-05-18 1994-11-25 Debiotech Syringe device for mixing two compounds
US5429603A (en) * 1990-12-04 1995-07-04 Medinject A/S Two-compartment syringe assembly and a method of producing a two-compartment syringe assembly
EP1039946A2 (en) * 1997-12-19 2000-10-04 Ernie Aranyi Fibrin mixture and dispenser assembly
WO2001000261A1 (en) * 1999-06-30 2001-01-04 Baxter International Inc. Syringe for transfer of medication from a prefilled medication container
US6234997B1 (en) * 1995-06-07 2001-05-22 Deka Products Limited Partnership System and method for mixing and delivering intravenous drugs
US20020177805A1 (en) * 2001-03-13 2002-11-28 Barker John M. Pre-filled safety diluent injector
US20030026849A1 (en) * 1997-10-15 2003-02-06 Thomas Jefferson University Nitric oxide donor compositions, methods, apparatus, and kits for preventing or alleviating vasoconstriction or vasospasm in a mammal
EP1308137A2 (en) * 2001-11-06 2003-05-07 Antonio Presta System and means for mixing impression materials for dentistry applications and the like
US20050094483A1 (en) * 2003-10-30 2005-05-05 Deka Products Limited Partnership Two-stage mixing system, apparatus, and method
US20050095576A1 (en) * 2003-10-30 2005-05-05 Deka Products Limited Partnership System, device, and method for mixing a substance with a liquid
US20050177100A1 (en) * 2003-10-24 2005-08-11 Harper Derek J. Dual chamber mixing syringe and method for use
WO2006037735A1 (en) * 2004-10-05 2006-04-13 Chemische Fabrik Kreussler & Co. Gmbh Device for producing a medical foam
US20090204066A1 (en) * 2006-06-21 2009-08-13 Novo Nordisk A/S One-Hand Operated Drug Mixing and Expelling Device
US20090216184A1 (en) * 2006-03-07 2009-08-27 Novo Nordisk A/S Drug storage and delivery device
US7662139B2 (en) 2003-10-30 2010-02-16 Deka Products Limited Partnership Pump cassette with spiking assembly
WO2010089621A1 (en) * 2009-02-06 2010-08-12 Tecres S.P.A. Supply unit for a mixer of two-phase compounds
US20100331773A1 (en) * 2007-11-22 2010-12-30 Novo Nordisk Healthcare A/G Medical mixing device
US20110176382A1 (en) * 2010-01-15 2011-07-21 Spine Wave, Inc. Systems and Methods for Mixing Fluids
US20120092951A1 (en) * 2009-02-06 2012-04-19 Tecres S.P.A. Mixer for biphasic compounds
US20130253464A1 (en) * 2010-11-18 2013-09-26 Raumedic Ag Metering device
US8834449B2 (en) 2012-01-23 2014-09-16 Ikomed Technologies, Inc. Mixing syringe
EP2923687A1 (en) * 2014-03-27 2015-09-30 Taiwan Biomaterial Co., Ltd. Syringe
CN105530975A (en) * 2013-09-16 2016-04-27 硕腾服务有限责任公司 Assembly for sequentially delivering substances, and associated methods
US9751056B2 (en) 2012-01-23 2017-09-05 Merit Medical Systems, Inc. Mixing syringe
USD807502S1 (en) 2015-03-02 2018-01-09 Neomed, Inc. Enteral syringe

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Cited By (64)

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Publication number Priority date Publication date Assignee Title
US4036225A (en) * 1974-09-19 1977-07-19 Maury Jean Robert Bicompartmental syringe
US4066067A (en) * 1975-03-21 1978-01-03 Dematex Development & Investment Establishment Vial stopper for blood sampling device
US4059109A (en) * 1976-07-27 1977-11-22 Tischlinger Edward A Mixing and dispensing disposable medicament injector
US4188949A (en) * 1977-07-05 1980-02-19 Becton, Dickinson & Company Sequential injection syringe
FR2400368A1 (en) * 1977-08-15 1979-03-16 Abbott Lab Prefilled syringe has two compartments
US4171698A (en) * 1977-08-15 1979-10-23 Abbott Laboratories Prefilled two-compartment syringe
US4808184A (en) * 1985-05-14 1989-02-28 Laboratorium Fur Experimentelle Chirurgie Forschungsinstitut Method and apparatus for preparing a self-curing two component powder/liquid cement
US4781679A (en) * 1986-06-12 1988-11-01 Abbott Laboratories Container system with integral second substance storing and dispensing means
US4886495A (en) * 1987-07-08 1989-12-12 Duoject Medical Systems Inc. Vial-based prefilled syringe system for one or two component medicaments
US5364369A (en) * 1987-07-08 1994-11-15 Reynolds David L Syringe
US5137511A (en) * 1987-07-08 1992-08-11 Duoject Medical Systems Inc. Syringe
US5019052A (en) * 1989-09-12 1991-05-28 David Bull Laboratories Pty. Ltd. Bipartite injector device
US4994029A (en) * 1989-09-12 1991-02-19 David Bull Laboratories Pty. Ltd. Syringe mixer and injector device
US5429603A (en) * 1990-12-04 1995-07-04 Medinject A/S Two-compartment syringe assembly and a method of producing a two-compartment syringe assembly
US5171214A (en) * 1990-12-26 1992-12-15 Abbott Laboratories Drug storage and delivery system
FR2705240A1 (en) * 1993-05-18 1994-11-25 Debiotech Syringe device for mixing two compounds
US6234997B1 (en) * 1995-06-07 2001-05-22 Deka Products Limited Partnership System and method for mixing and delivering intravenous drugs
US20040176724A1 (en) * 1997-08-22 2004-09-09 Kamen Dean L, Cassette and method for drug preparation and delivery
US7214210B2 (en) 1997-08-22 2007-05-08 Deka Products Limited Partnership Cassette and method for drug preparation and delivery
US6464667B1 (en) 1997-08-22 2002-10-15 Deka Products Limited Partnership Method and cassette for delivering intravenous drugs
US6796966B2 (en) * 1997-10-15 2004-09-28 Jeffrey E. Thomas Apparatus, and kits for preventing of alleviating vasoconstriction or vasospasm in a mammal
US20030026849A1 (en) * 1997-10-15 2003-02-06 Thomas Jefferson University Nitric oxide donor compositions, methods, apparatus, and kits for preventing or alleviating vasoconstriction or vasospasm in a mammal
EP1039946A2 (en) * 1997-12-19 2000-10-04 Ernie Aranyi Fibrin mixture and dispenser assembly
EP1955727A3 (en) * 1997-12-19 2008-11-05 United States Surgical Corporation Fibrin mixture and dispenser assembly
EP1039946A4 (en) * 1997-12-19 2004-07-21 United States Surgical Corp Fibrin mixture and dispenser assembly
WO2001000261A1 (en) * 1999-06-30 2001-01-04 Baxter International Inc. Syringe for transfer of medication from a prefilled medication container
US20020177805A1 (en) * 2001-03-13 2002-11-28 Barker John M. Pre-filled safety diluent injector
US6981963B2 (en) 2001-03-13 2006-01-03 Mdc Investment Holdings, Inc. Pre-filled safety diluent injector
EP1308137A3 (en) * 2001-11-06 2003-09-10 Antonio Presta System and means for mixing impression materials for dentistry applications and the like
EP1308137A2 (en) * 2001-11-06 2003-05-07 Antonio Presta System and means for mixing impression materials for dentistry applications and the like
US20050177100A1 (en) * 2003-10-24 2005-08-11 Harper Derek J. Dual chamber mixing syringe and method for use
US7951108B2 (en) * 2003-10-24 2011-05-31 Mdc Investment Holdings, Inc. Dual chamber mixing syringe and method for use
US20090018496A1 (en) * 2003-10-24 2009-01-15 Mdc Investment Holdings, Inc. Dual chamber mixing syringe and method for use
US20050094483A1 (en) * 2003-10-30 2005-05-05 Deka Products Limited Partnership Two-stage mixing system, apparatus, and method
US7632080B2 (en) 2003-10-30 2009-12-15 Deka Products Limited Partnership Bezel assembly for pneumatic control
US20050095576A1 (en) * 2003-10-30 2005-05-05 Deka Products Limited Partnership System, device, and method for mixing a substance with a liquid
US8158102B2 (en) 2003-10-30 2012-04-17 Deka Products Limited Partnership System, device, and method for mixing a substance with a liquid
US20050094485A1 (en) * 2003-10-30 2005-05-05 Deka Products Limited Partnership System, device, and method for mixing liquids
US7354190B2 (en) 2003-10-30 2008-04-08 Deka Products Limited Partnership Two-stage mixing system, apparatus, and method
US7632078B2 (en) 2003-10-30 2009-12-15 Deka Products Limited Partnership Pump cassette bank
US7461968B2 (en) 2003-10-30 2008-12-09 Deka Products Limited Partnership System, device, and method for mixing liquids
US20050095141A1 (en) * 2003-10-30 2005-05-05 Deka Products Limited Partnership System and method for pumping fluid using a pump cassette
US20050095154A1 (en) * 2003-10-30 2005-05-05 Deka Products Limited Partnership Bezel assembly for pneumatic control
US7662139B2 (en) 2003-10-30 2010-02-16 Deka Products Limited Partnership Pump cassette with spiking assembly
US20050095153A1 (en) * 2003-10-30 2005-05-05 Deka Products Limited Partnership Pump cassette bank
US20050095152A1 (en) * 2003-10-30 2005-05-05 Deka Products Limited Partnership Door locking mechanism
WO2006037735A1 (en) * 2004-10-05 2006-04-13 Chemische Fabrik Kreussler & Co. Gmbh Device for producing a medical foam
US20090216184A1 (en) * 2006-03-07 2009-08-27 Novo Nordisk A/S Drug storage and delivery device
US8323237B2 (en) 2006-06-21 2012-12-04 Novo Nordisk Healthcare Ag One-hand operated drug mixing and expelling device
US20090204066A1 (en) * 2006-06-21 2009-08-13 Novo Nordisk A/S One-Hand Operated Drug Mixing and Expelling Device
US20100331773A1 (en) * 2007-11-22 2010-12-30 Novo Nordisk Healthcare A/G Medical mixing device
US9016925B2 (en) * 2009-02-06 2015-04-28 Tecres S.P.A. Mixer for biphasic compounds
US20120092951A1 (en) * 2009-02-06 2012-04-19 Tecres S.P.A. Mixer for biphasic compounds
US9643139B2 (en) 2009-02-06 2017-05-09 Tecres S.P.A. Supply unit for a mixer of two-phase compounds
WO2010089621A1 (en) * 2009-02-06 2010-08-12 Tecres S.P.A. Supply unit for a mixer of two-phase compounds
US20110176382A1 (en) * 2010-01-15 2011-07-21 Spine Wave, Inc. Systems and Methods for Mixing Fluids
US8657481B2 (en) * 2010-01-15 2014-02-25 Spine Wave, Inc. Systems and methods for mixing fluids
US20130253464A1 (en) * 2010-11-18 2013-09-26 Raumedic Ag Metering device
US9237987B2 (en) * 2010-11-18 2016-01-19 Raumedic Ag Metering device
US8834449B2 (en) 2012-01-23 2014-09-16 Ikomed Technologies, Inc. Mixing syringe
US9751056B2 (en) 2012-01-23 2017-09-05 Merit Medical Systems, Inc. Mixing syringe
CN105530975A (en) * 2013-09-16 2016-04-27 硕腾服务有限责任公司 Assembly for sequentially delivering substances, and associated methods
EP2923687A1 (en) * 2014-03-27 2015-09-30 Taiwan Biomaterial Co., Ltd. Syringe
USD807502S1 (en) 2015-03-02 2018-01-09 Neomed, Inc. Enteral syringe

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