US3494359A - Two compartment syringe with a single barrel - Google Patents

Two compartment syringe with a single barrel Download PDF

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Publication number
US3494359A
US3494359A US3494359DA US3494359A US 3494359 A US3494359 A US 3494359A US 3494359D A US3494359D A US 3494359DA US 3494359 A US3494359 A US 3494359A
Authority
US
Grant status
Grant
Patent type
Prior art keywords
barrel
compartment
separator
syringe
wall
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
Eli A Zackheim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SILVER INDUSTRIES Inc
SILVER INDUSTRIES Inc A CORP OF CT
JULES SILVER
SILVER JULES
Original Assignee
SILVER JULES
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/286Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
    • A61M2005/287Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst by displacing occluding plugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/286Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst

Description

TWO COMPARTMENT SYRINGE WITH A SINGLE BARREL Filed March 17, 1969 j I INVENTOR 6 Eu ,4. ZACAHi/M MQIM-YM ATTORNEY!" United States Patent US. Cl. 128218 6 Claims ABSTRACT OF THE DISCLOSURE A disposable, two compartment syringe assembly which is comprised of a single barrel member separated into first and second compartments by means of a separator which is positioned transversely across the barrel. The separator rests on a support on the inner side wall of the barrel forming a cam for the separator. Two materials may be kept within the barrel in each of the compartments in an unmixed state until mixing is desired. To use the syringe a plunger is depressed into the barrel causing the material in the compartment above the separator to act against the separator causing it to be cammed out of a transverse position in the barrel so that the material in the first compartment may flow into the second compartment mixing with the material therein. A continued stroke of the plunger causes the separator to travel with the plunger against the mixed material forcing it out through an opening in the bottom of the barrel and then into a needle.

DISCLOSURE OF THE INVENTION The present invention relates to an improved syringe of the type having two compartments. More particularly, the invention relates to disposable hypodermic syringes where two materials are stored in separate compartments until shortly before they are desired to be used as a mixture and ejected from the syringe.

The use of two compartment hypodermic syringes is well established. In many cases it is desired to keep a powdered pharmaceutical or medicament in one compartment of a syringe but sealed off from a diluent or solvent stored in another compartment. Prior to use, the dilutent or solvent is forced through some sealing means into the compartment containing the pharmaceutical or medicament. There they are mixed together and then the mixed material is forced out through a hypodermic needle, canula or opening.

Generally, the most efiicient two compartment syringes have normally been made from two barrels, one within the other. A typical two barrel syringe is shown in US. Patent No. 3,052,239, issued Sept. 4, 1962 to Jules Silver et al. Some attempts have been made to provide a two compartment syringe formed within a single barrel. However, as far as it is known, such single barrel units require intricate valve means in order to move the material from one compartment to the other. As examples of such prior art devices, reference is made to US. Patent No. 3,380,451, issued Apr. 30, 1968 to Porter et al. and US. Patent No. 2,591,046, issued Apr. 1, 1952 to Brown.

In the present invention only a slight alteration need be done to a single barrel syringe and a simple separator added as an additional part to it in order to convert the single barrel syringe to a usable two compartment syringe.

Accordingly, it is an object of the present invention to provide an improved, disposable two compartment syringe which is economical to manufacture, has a minimum number of parts to assemble, is easy to use and may be discarded after use if desired.

These and other objects and advantages of the present 3,494,359 Patented Feb. 10, 1970 "ice invention will be obvious from a description of the illustrated embodiment of the invention as shown in the drawings. While the drawings and the illustrated embodiment are for the purpose of enlightening those skilled in the art, the single embodiment is not to be considered as limiting the invention.

In the drawings:

FIGURE 1 is an exploded side view showing the various components of the present invention;

FIGURE 2 is a sectional side view of the two compartments of the present invention;

FIGURE 3 is similar to FIGURE 2 but with the plunger partially depressed to cam the separator to slightly tilted position permitting material to pass from one compartment to the other;

FIGURE 4 is similar to FIGURE 2 but with the plunger contacting the separator and moved past the support;

FIGURE 5 is similar to FIGURE 2 with the plunger and the separator adjacent to each other and moved to the bottom of the barrel of the syringe; and

FIGURE 6 is a plan section through the barrel of FIGURE 2 showing the support in relation to the side wall.

Referring to the drawings and to FIGURE 1 in particular, a syringe 10 in accordance with the present invention is shown as an exploded assembly of several components. The syringe is comprised of a barrel portion 12 into which is fitted a plunger 14. A compartment separator 16 is positioned transversely within the barrel 12 and rests on a support member 18. A needle 20 is attached to the barrel 12 and may be protected if desired by a needle cap 22. It is understood that a canula or any opening may be used.

As shown in FIGURES 2 through 5, the barrel 12 is generally of cylindrical shape comprised of a side wall 24 and a bottom wall 26. An opening 28 is provided in the bottom wall 26 and this opening communicates with the needle 20.

The separator 16 divides the barrel 12 into a lower compartment 30 and an upper compartment 32. Into the upper compartment 32, a first material in the form of a solvent or dilutent (in the illustrated embodiment) is placed. A second material (in the illustrated embodiment in the form of a powder) 34 is placed in the lower compartment 30. Advantageously, the separator 16 is in liquid type contact with the side wall 24 and therefore the materials in the upper and lower compartments 30 and 32 are kept separated from each other.

A seal plate 38 is provided on the stem 40 of the plunger 14. A thumb piece 42 is provided on the upper end of the plunger, and a finger flange 44 is provided on the barrel 12 to provide finger grips for the user.

As shown in FIGURE 2, the separator 16 rests on a support in the form of the abutment 18, the abutment being only a few mils thick.

The extent and size of the abutment 18 will depend upon several factors, including the diameter of the barrel, the types of materials involved and so forth. In actual practice, an abutment of at least five mils has been found to be desirable.

In order to move material from the upper compartment 32 into the lower compartment 30, the plunger is forced downwardly into the barrel in a piston-like action. The seal plate 38 is maintained in liquid tight engagement with the side wall of the barrel and forces the material in the upper compartment 32 against the separator 16. The pressure on the separator 16 is such that the abutment 18 adds support to the area 46 of the separator in contact with it acting as a cam. The remainder of the separator is not so supported and since the edge 48 of the separator 16 away from the abutment 18 is unsupported, the pressure exerted by the seal plate 38 causes that edge 48 to be forced downwardly. As it is forced downwardly it forms a passage way between the side wall and the edge permitting any material in the upper compartment 32 to pass into the lower compartment 30. The camming of the separator is particularly shown in FIGURE 3.

As shown in FIGURE 4, after the plunger with its seal plate 38 has passed by the support 18, it becomes aligned with the separator 16 and they continue downwardly together towards the opening 28 in the bottom wall 26.

Due to the downwardly stroke of the plunger, all the mixed material in the lower compartment 30 is forced out of the opening 28.

When the syringe is to be disposed of after a single use, it is advantageously made from low cost plastic materials. The barrel, plunger and separator may be readily molded from material such as polyethylene or polypropylene. The only requirement is that the material used for the separator and the seal plate on the plunger be preferably and advantageously self-lubricating to permit them to move slidably through the barrel along the side wall without the need of additional lubrication.

The needle 20, if it is to be used to make an injection through the skin of a body of a human or an animal of course must be of a metallic nature such as a hollow steel needle. On the other hand though, if it is to be inserted into an opening such as the canal in the teat of a cow, it can be of a plastic material and molded integrally with the lower barrel 12. From the foregoing it is obvious that the present invention meets the objects and requirements as set forth herein'before.

What is claimed is:

1. An improved two compartment syringe of the type adapted to be used with a hollow member, comprising:

a barrel having side and bottom walls and an open end opposite said bottom wall, an opening in the bottom wall adapted to be connected to the member or other P a plunger having a seal plate and positioned within the side wall of the barrel in slidable but liquid-tight relationship therewith,

a cam on the inner surface of the side wall and extending less than about half way around the inner circumference of the side wall,

a separator positioned transversely across the barrel and adjacent to the cam, said separator being in liquid-tight relationship with the side wall of the barrel and positioned between the cam and the seal plate on the plunger,

said separator dividing sa-id barrel into two compartments whereby two separate materials may be stored in each compartment and mixed together by forcing the seal plate towards the separator so that the material in the compartment adjacent to the seal plate forces the separator against the cam causing it to be forced out of liquid-tight relationship with the side wall of the barrel permitting the two separate materials to be mixed together.

2. An improved two compartment syringe as defined in claim 1 wherein the separator is slidably mounted with respect to the side wall and adapted to be moved by the plunger to a position between the cam and the opening in the bottom wall.

3. An improved two compartment syringe as defined in claim 1 wherein the barrel has a longitudinal axis parallel to the side wall and extending through the opening in the bottom wall, and the separator is aligned in ap lane substantially transverse to the longitudinal axis of the barrel.

4. An improved two compartment syringe as defined in claim 1 wherein the separator is aligned in a plane substantially parallel to the plunger seal plate.

5. An improved two compartment syringe as defined in claim 1 wherein the side wall is cylindrical and the cam extends inwardly from the side walls.

6. An improved two compartment syringe as defined in claim 5 wherein the cam extends at least five mils inwardly from the side wall.

References Cited UNITED STATES PATENTS 1,929,616 10/1933 Vopata 128-272 2,390,246 12/ 1945 Folkman 128-215 2,549,417 4/1951 Brown 128---272 3,052,239 9/ 1962 Silver et al. 3,052,240 9/1962 Silver et al. 3,380,451 4/1968 Porter et al.

RICHARD A. GAUDET, Primary Examiner MARTIN F. MAJESTIC, Assistant Examiner U .5. Cl. X.R. 128-272; 222137

US3494359A 1969-03-17 1969-03-17 Two compartment syringe with a single barrel Expired - Lifetime US3494359A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US80769069 true 1969-03-17 1969-03-17

Publications (1)

Publication Number Publication Date
US3494359A true US3494359A (en) 1970-02-10

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Family Applications (1)

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US3494359A Expired - Lifetime US3494359A (en) 1969-03-17 1969-03-17 Two compartment syringe with a single barrel

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US (1) US3494359A (en)
JP (1) JPS504992B1 (en)
BE (1) BE747421A (en)
DE (1) DE2012607C3 (en)
FR (1) FR2037959A5 (en)
GB (1) GB1300163A (en)

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3563415A (en) * 1969-06-04 1971-02-16 Multi Drop Adapter Corp Multidrop adapter
US3595439A (en) * 1969-09-09 1971-07-27 Minnesota Mining & Mfg Combination mixing capsule and dispenser
US3662753A (en) * 1970-05-25 1972-05-16 Kitchener B Tassell Syringe
US3739947A (en) * 1969-08-01 1973-06-19 E Baumann Storing and mixing receptacle
US3858580A (en) * 1969-06-04 1975-01-07 Ims Ltd Intravenous container mixing assembly
US4128136A (en) * 1977-12-09 1978-12-05 Lamage Limited Drill bit
US4172457A (en) * 1977-10-06 1979-10-30 American Hospital Supply Corporation Plural component mixing system and method
US4208133A (en) * 1978-01-07 1980-06-17 Korte-Jungermann Gesellschaft fur Fassadenbau und Befesstigungstechnik mit beschrankter Haftung Injection cartridge
US4366919A (en) * 1978-05-01 1983-01-04 Coaxial Cartridges, Inc. Composite cartridge and device for metering extrusion of contents
US4394863A (en) * 1981-10-23 1983-07-26 Survival Technology, Inc. Automatic injector with cartridge having separate sequentially injectable medicaments
US4463875A (en) * 1982-06-14 1984-08-07 Robert W. Mann Method and apparatus for preparing and applying a two-component cement
US4689042A (en) * 1985-05-20 1987-08-25 Survival Technology, Inc. Automatic medicament ingredient mixing and injecting apparatus
DE3618318A1 (en) * 1986-05-30 1987-12-03 Rau Roland Hypodermic syringe
WO1991000094A1 (en) * 1989-06-28 1991-01-10 Finn Tranberg A new papaverine injection system
US4994043A (en) * 1987-06-16 1991-02-19 Akzo N.V. Two compartment syringe
US5137528A (en) * 1990-11-26 1992-08-11 Crose Virginia W Ampoule for administering a liquid local anaesthetic
US5301842A (en) * 1991-03-06 1994-04-12 Frank Ritter Multicomponent cartridge for plastic materials
US5472422A (en) * 1992-07-07 1995-12-05 Pharmacia Aktiebolag Dual-chamber injection cartridge
US5522804A (en) * 1994-02-15 1996-06-04 Lynn; Lawrence A. Aspiration, mixing, and injection syringe
DE29605790U1 (en) * 1996-03-28 1996-08-08 Thomae Gmbh Dr K Syringe for medical purposes
US5662472A (en) * 1995-08-18 1997-09-02 Dentsply Gmbh Hue and lightness identification system for dental products
US5817055A (en) * 1992-07-07 1998-10-06 Pharmacia & Upjohn Aktiebolag Dual-chamber injection cartridge
US20040079363A1 (en) * 2001-01-12 2004-04-29 Casper Robert A. Medicament respiratory delivery device and method
US20050000514A1 (en) * 2001-01-12 2005-01-06 Becton, Dickinson And Company Medicament microdevice delivery system, cartridge and method of use
US20050113768A1 (en) * 2003-11-24 2005-05-26 Carlos Patrickson Pain-alleviating injection needle
US20080091148A1 (en) * 2006-10-17 2008-04-17 Arte Corporation Combined container-syringe
US20080215012A1 (en) * 2005-02-02 2008-09-04 Taisei Kakoco., Ltd. Syringe
US20080230565A1 (en) * 2005-10-14 2008-09-25 Arno Hohmann Plunger and Plunger Assembly For a Cartridge, System For Storing a Substance, and Method of Filling and Sealing a Substance in a Delivery System
US20100249829A1 (en) * 2009-03-30 2010-09-30 Derek Rissman Compartmented Syringe
US8057090B1 (en) * 2005-08-31 2011-11-15 Subrata Saha Automated bone cement mixer
US8865857B2 (en) 2010-07-01 2014-10-21 Sofradim Production Medical device with predefined activated cellular integration
US9247931B2 (en) 2010-06-29 2016-02-02 Covidien Lp Microwave-powered reactor and method for in situ forming implants
US9510810B2 (en) 2009-02-21 2016-12-06 Sofradim Production Medical devices incorporating functional adhesives
US9775928B2 (en) 2013-06-18 2017-10-03 Covidien Lp Adhesive barbed filament

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4018222A (en) * 1975-02-10 1977-04-19 Merck & Co., Inc. Syringe containing frozen vaccine
DE7916475U1 (en) * 1979-06-08 1979-10-18 Hoechst Ag, 6000 Frankfurt
FR2539302B1 (en) * 1983-01-17 1986-03-14 Brunet Jean Louis Syringe for medical purposes
WO2000062828A1 (en) 1996-04-30 2000-10-26 Medtronic, Inc. Autologous fibrin sealant and method for making the same
EP1577227B1 (en) * 2004-03-11 2006-06-07 3M Espe Ag Capsule for storage, mixing and dispensing materials

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1929616A (en) * 1932-04-29 1933-10-10 William O Vopata Double compartment ampule
US2390246A (en) * 1940-10-18 1945-12-04 Marvin L Folkman Syringe
US2549417A (en) * 1949-08-10 1951-04-17 Frederick M Turnbull Syringe ampoule
US3052240A (en) * 1959-01-29 1962-09-04 Silver Disposable hypodermic syringe
US3052239A (en) * 1959-01-29 1962-09-04 Silver Disposable hypodermic syringe
US3380451A (en) * 1965-06-14 1968-04-30 Robert E. Porter Two compartment syringe

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1929616A (en) * 1932-04-29 1933-10-10 William O Vopata Double compartment ampule
US2390246A (en) * 1940-10-18 1945-12-04 Marvin L Folkman Syringe
US2549417A (en) * 1949-08-10 1951-04-17 Frederick M Turnbull Syringe ampoule
US3052240A (en) * 1959-01-29 1962-09-04 Silver Disposable hypodermic syringe
US3052239A (en) * 1959-01-29 1962-09-04 Silver Disposable hypodermic syringe
US3380451A (en) * 1965-06-14 1968-04-30 Robert E. Porter Two compartment syringe

Cited By (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3563415A (en) * 1969-06-04 1971-02-16 Multi Drop Adapter Corp Multidrop adapter
US3858580A (en) * 1969-06-04 1975-01-07 Ims Ltd Intravenous container mixing assembly
US3739947A (en) * 1969-08-01 1973-06-19 E Baumann Storing and mixing receptacle
US3595439A (en) * 1969-09-09 1971-07-27 Minnesota Mining & Mfg Combination mixing capsule and dispenser
US3662753A (en) * 1970-05-25 1972-05-16 Kitchener B Tassell Syringe
USRE29062E (en) * 1972-11-01 1976-12-07 Ims Limited Intravenous container mixing assembly
US4172457A (en) * 1977-10-06 1979-10-30 American Hospital Supply Corporation Plural component mixing system and method
US4243080A (en) * 1977-10-06 1981-01-06 American Hospital Supply Corporation Method of mixing plural components
US4128136A (en) * 1977-12-09 1978-12-05 Lamage Limited Drill bit
US4208133A (en) * 1978-01-07 1980-06-17 Korte-Jungermann Gesellschaft fur Fassadenbau und Befesstigungstechnik mit beschrankter Haftung Injection cartridge
US4366919A (en) * 1978-05-01 1983-01-04 Coaxial Cartridges, Inc. Composite cartridge and device for metering extrusion of contents
US4394863A (en) * 1981-10-23 1983-07-26 Survival Technology, Inc. Automatic injector with cartridge having separate sequentially injectable medicaments
US4463875A (en) * 1982-06-14 1984-08-07 Robert W. Mann Method and apparatus for preparing and applying a two-component cement
US4689042A (en) * 1985-05-20 1987-08-25 Survival Technology, Inc. Automatic medicament ingredient mixing and injecting apparatus
US4755169A (en) * 1985-05-20 1988-07-05 Survival Technology, Inc. Automatic medicament ingredient mixing and injecting apparatus
DE3618318A1 (en) * 1986-05-30 1987-12-03 Rau Roland Hypodermic syringe
US4994043A (en) * 1987-06-16 1991-02-19 Akzo N.V. Two compartment syringe
WO1991000094A1 (en) * 1989-06-28 1991-01-10 Finn Tranberg A new papaverine injection system
US5137528A (en) * 1990-11-26 1992-08-11 Crose Virginia W Ampoule for administering a liquid local anaesthetic
US5301842A (en) * 1991-03-06 1994-04-12 Frank Ritter Multicomponent cartridge for plastic materials
US5472422A (en) * 1992-07-07 1995-12-05 Pharmacia Aktiebolag Dual-chamber injection cartridge
US5817055A (en) * 1992-07-07 1998-10-06 Pharmacia & Upjohn Aktiebolag Dual-chamber injection cartridge
US5743886A (en) * 1994-02-15 1998-04-28 Lawrence A. Lynn Sequential medical fluid aspiration and injection system and method
US5549569A (en) * 1994-02-15 1996-08-27 Lawrence A. Lynn Ex vivo blood isolation system
US5643218A (en) * 1994-02-15 1997-07-01 Lawrence A. Lynn Auto-flushing medical fluid injection system
US5522804A (en) * 1994-02-15 1996-06-04 Lynn; Lawrence A. Aspiration, mixing, and injection syringe
US5769825A (en) * 1994-02-15 1998-06-23 Lynn; Lawrence A. Self-contained syringe and pharmaceutical packaging system for enclosed mixing of pharmaceutical and diluent
US5697915A (en) * 1994-02-15 1997-12-16 Lynn; Lawrence A. Displacement-activated medical check valve
US6228065B1 (en) 1994-02-15 2001-05-08 Lawrence A. Lynn Displacement activated medical check valve
US5662472A (en) * 1995-08-18 1997-09-02 Dentsply Gmbh Hue and lightness identification system for dental products
WO1997036624A1 (en) * 1996-03-28 1997-10-09 Dr. Karl Thomae Gmbh Syringe for medicinal purposes
DE29605790U1 (en) * 1996-03-28 1996-08-08 Thomae Gmbh Dr K Syringe for medical purposes
US20040079363A1 (en) * 2001-01-12 2004-04-29 Casper Robert A. Medicament respiratory delivery device and method
US20050000514A1 (en) * 2001-01-12 2005-01-06 Becton, Dickinson And Company Medicament microdevice delivery system, cartridge and method of use
US8251958B2 (en) 2001-01-12 2012-08-28 Becton, Dickinson And Company Medicament microdevice delivery system, cartridge and method of use
US7051734B2 (en) 2001-01-12 2006-05-30 Becton Dickinson And Company Medicament respiratory delivery device and method
US7850663B2 (en) 2001-01-12 2010-12-14 Becton, Dickinson And Company Medicament microdevice delivery system, cartridge and method of use
US20050113768A1 (en) * 2003-11-24 2005-05-26 Carlos Patrickson Pain-alleviating injection needle
US20080215012A1 (en) * 2005-02-02 2008-09-04 Taisei Kakoco., Ltd. Syringe
US7935078B2 (en) * 2005-02-02 2011-05-03 Taisei Kako Co., Ltd. Multi-chambered syringe
US8057090B1 (en) * 2005-08-31 2011-11-15 Subrata Saha Automated bone cement mixer
US8382363B1 (en) * 2005-08-31 2013-02-26 Subrata Saha Automated bone cement mixer
US9844796B2 (en) * 2005-10-14 2017-12-19 3M Innovative Properties Company Plunger and plunger assembly for a cartridge, system for storing a substance, and method of filling and sealing a substance in a delivery system
US20080230565A1 (en) * 2005-10-14 2008-09-25 Arno Hohmann Plunger and Plunger Assembly For a Cartridge, System For Storing a Substance, and Method of Filling and Sealing a Substance in a Delivery System
US20080091148A1 (en) * 2006-10-17 2008-04-17 Arte Corporation Combined container-syringe
US9510810B2 (en) 2009-02-21 2016-12-06 Sofradim Production Medical devices incorporating functional adhesives
US8376989B2 (en) 2009-03-30 2013-02-19 Covidien Lp Compartmented syringe
US20100249829A1 (en) * 2009-03-30 2010-09-30 Derek Rissman Compartmented Syringe
US9247931B2 (en) 2010-06-29 2016-02-02 Covidien Lp Microwave-powered reactor and method for in situ forming implants
US8865857B2 (en) 2010-07-01 2014-10-21 Sofradim Production Medical device with predefined activated cellular integration
US9775928B2 (en) 2013-06-18 2017-10-03 Covidien Lp Adhesive barbed filament

Also Published As

Publication number Publication date Type
DE2012607A1 (en) 1970-10-01 application
DE2012607C3 (en) 1980-01-24 grant
BE747421A1 (en) grant
JPS504992B1 (en) 1975-02-26 grant
GB1300163A (en) 1972-12-20 application
BE747421A (en) 1970-08-31 grant
DE2012607B2 (en) 1979-05-23 application
FR2037959A5 (en) 1970-12-31 application

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