US3489147A - Combination mixing and injecting medical syringe - Google Patents

Combination mixing and injecting medical syringe Download PDF

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US3489147A
US3489147A US3489147DA US3489147A US 3489147 A US3489147 A US 3489147A US 3489147D A US3489147D A US 3489147DA US 3489147 A US3489147 A US 3489147A
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gasket
barrel
needle
ingredient
inner barrel
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Joseph Denman Shaw
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Joseph Denman Shaw
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096Combination of a vial and a syringe for transferring or mixing their contents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093Containers having several compartments for products to be mixed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/201Piercing means having one piercing end
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/2013Piercing means having two piercing ends
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202Separating means
    • A61J1/2027Separating means having frangible parts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • A61M2005/31598Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing having multiple telescopically sliding coaxial pistons encompassing volumes for components to be mixed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/288Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened by piercing without internal pressure increase

Description

Jan. 13, 1970 J. D.'sH'Aw 3,489,147

COMBINATION MIXING AND INJECTING MEDICAL SYRINGE Original Filed July 21, 1964 2 Sheets-Sheet 1 III/i111 INVENTOR. 7555 ,2, dfi/P'W J. D. SHAW I Jan. 13,1970

COMBINATION MIXING AND INJECTING MEDICAL SYRINGE 2 Sheets-Sheet 2 Original Filed July 21, 1964 United States Patent 3,489,147 COMBINATION MIXING AND INJECTING MEDICAL SYRINGE Joseph Denman Shaw, 508 Church St.,

Brownsville, Pa. 15417 Continuation of application Ser. No. 384,148, July 21,

1964. This application Aug. 22, 1967, Ser. No. 662,340 Int. Cl. A61m /00; A61j 1/00; B67d 5/56 US. Cl. 128218 4 Claims ABSTRACT OF THE DISCLOSURE A combined mixing and injecting syringe has an outer barrel to contain a first ingredient and provided with an injection outlet, has an inner barrel slidable in a sealed manner longitudinally of the outer barrel for containing a second ingredient, and has a plunger slidable in a sealed manner longitudinally of the barrel. The inner barrel has a discharge opening communicating with the hollow of the outer barrel and normally closed by a gasket. A needle carried by the plunger is in position to pierce this gasket upon relative movement of the plunger in the inner barrel and then adapted to provide communication for the free exit of the second ingredient from the inner barrel to mix with the first ingredientin the outer barrel, after which the mixture may be injected by relative movement of the two barrels.

This is a continuation of application Ser. No. 384,148, filed July 21, 1964, and now abandoned.

This invention relates to a combined mixing and injecting syringe useful among other things in medical practice for the injection of a twoingredient mixture.

One of the objects of the present invention is the provision of a syringe whereby one ingredient, such as a powder or liquid, may be dissolved in a suitable diluent second ingredient and then injected into a patient by the use of this novel syringe.

Other objects of this invention include the arrangement of the parts for quick assembly and disassembly for loading or cleaning, means for quickly measuring the amounts of the mixed ingredients, and other objects and advantages as will be apparent in the accompanying drawings and description.

In the drawings:

FIG. 1 is a central sectional view through one embodiment of my invention;

FIG. 2 is a sectional view of an intermediate portion of FIG. 1 with the parts in a diiferent actuated position;

FIG. 3 is a cross-sectional view, enlarged, taken along the line 15-15 of FIG. 2;

FIG. 4 is a crosssectional view showing another noncircular section through the parts similar to FIG. 3 and illustrating how an embodiment of FIGS. 1 and 2 might be constructed;

FIG. 5 is a central sectional view through another embodiment of this invention;

FIG. 6 is a cross-sectional view taken along the line 1818 of FIG. 5; and

FIG. 7 is a central sectional view of the intermediate portion of FIG. 5 showing an operated position of the parts.

Prior to this invention, to the best of my knowledge and belief, there has been an unmet need for a mixing syringe wherein two or more ingredients could be easily placed in separate chambers of the syringe with no mixing occurring until just before the injection of the combined ingredients into a patient and constructed with easily manipulated parts whereby a breachable passageway communicating with the chambers containing the separate ingredients is adapted to be easily and quickly opened followed by mixing of the ingredients in a mixing chamber and the immediate propulsion of the contents out of the syringe.

In FIGS. 1 and 2, is shown one embodiment of this invention. Here the outer barrel 73 has a discharge outlet 74 which may be closed if desired by a cap 75. An inner barrel 76 is reciprocatable in the outer barrel and is sealed thereagainst by a gasket 77. A plunger 78 is reciprocatable in the inner barrel and is sealed thereagainst by a gasket 79. Here the breachable means for initially sealing off the contents of the ingredients in chamber 80 and the ingredients in chamber 81 comprises a portion of the gasket 77 which is impervious at 77a where the contents of chamber 81 passing through a discharge opening 82 might reach the chamber 80 if it were not for the gasket portion 77a. For breaching this closure there is provided a hollow needle 83 which engages, or preferably is embedded in, the material of the gasket portion 77a as shown in FIG. 1. The opposite end of the needle is in position to communicate with the chamber 81 in the inner barrel but is temporarily sealed from such communication by means of a penetratable seal 84. Means is provided for relative movement of the inner barrel against the lower end of needle 83 as seen in FIG. 13 and for causing this needle to perforate the gasket portion 77a. The means here shown comprises a hollow neck 76a on the inner barrel 76 and provided with a male outer thread which coacts with a female inner thread 85 formed in a recess in gasket 77. A projection 86 rigid with the needle 83 is provided for a purpose which will presently appear. In use of this device, with the inner barrel removed from the outer barrel, a measured amount of the first ingredient is placed in the chamber 80. Also, a measured amount of the second ingredient is placed in the chamber 81 and the plunger 78 pushed into proper position. The parts are then assembled as shown in FIG. 1. In this form of the invention, the outer barrel 73 and the coacting gasket 77 are non-circular in form as shown in FIG. 3. The corners are preferably rounded as shown so that a better seal may be had. Alternatively, some other form of non-circular barrel 73' might be adopted as in FIG. 4 with a gasket 77 of complementary shape, the forms here being elliptical. By rotating the inner barrel 76 about its longitudinal axis while holding the outer barrel 73 stationary, the threaded connection at 76a, 85 is operated to move the parts from the full line position of FIG. 1 about half way to the position shown in FIG. 2, thus causing a first penetration of the needle through the seal 84. Further operation of the threaded connection to the position shown in FIG. 2 will cause the end of the neck 76a to engage against the projection 86- on the needle, thus forcing the needle 83 through the gasket portion 77a and establishing communication between chambers 80 and 81. Movement of plunger 78 into barrel 76 will now discharge the contents of chamber 81 into the mixing chamber 80 to mix with the first ingredient there. The mixture may then be propelled through the discharge outlet 74 by movement of the inner barrel 76 and gasket 77.

FIG. 5 shows another embodiment of this invention which has great similarity to FIG. 1 except that the seal 84 is not required. Here outer barrel 87 has a discharge outlet 88 which can be closed if desired by a cap 89. An inner barrel 90 is reciprocatable in the barrel 87 and is sealed thereagainst by a gasket 91. This gasket has a gasket portion 91a which is impervious at the point where the second ingredient might mix with the first ingredient in the same manner as the gasket portion 77a described in FIG. 1. A hollow needle 92 is partially embedded in the gasket portion 91a at its pointed end, and has its other end rigidly secured in a projecting neck 90a of the inner barrel 90. A threaded connection is provided at 93 between the neck 90a and the gasket 91 for the purpose explained in connection with FIGS. 1 and 2. A plunger 94 is reciprocatable in inner barrel 90 and sealed thereagainst by a gasket 95. I have thus provided a first ingredient chamber 96 and a second ingredient chamber 97 which may be loaded in any of the manners previously explained and the parts placed in the position of FIG. 5. In this embodiment, the barrel 87 and the gasket 91 are circular in section so it is necessary to hold them manually if one is to actuate the threaded connection at 93. For this purpose the gasket 90 has a downwardly extending projection 91b which extends beyond the open end of the outer barrel 87 so as to be grasped by the fingers of the operator or otherwise. For sterility reasons it may be desirable to attach a sleeve 98 of flexible plastic or the like to the outside of barrel 87 covering the parts as shown in FIG. 5 so that the fingers may grip through the sleeve 98 against the projection 9112 so as to maintain the parts clean and sterile. With the parts so held, the threaded connection 93 is operated to cause relative movement of the neck 90a of the inner barrel relative to the gasket 91, thus forcing the needle 92 to penetrate the gasket portion 91a and provide communication between chambers 96 and 97. Then, operation of the plunger 94 will force the contents of chamber '97 through the hollow needle 92 into chamber 96 where they may be mixed and injected into the patient as previously described.

If the above operation is to be carried out as one-time operation and then the syringe is discarded, then further improvements described herein are unnecessary. In other words, the parts heretofore described will permit the plunger 94 and barrel 90 to drive the gasket 91 into the barrel 87 sufficiently to inject the mixed ingredients from chambers 96 and 97. However, if it is desired to reciprocate the gasket 91 in the barrel 87, then a male threaded portion 99 is provided in the center of the gasket 95 extending axially in position to coact with the female thread 100 found in the socket end of the needle 92. Then, just before the parts reach the position of FIG. 7, the threaded connection at 99, 100 may be completed by holding the gasket projection 91b against rotation about its axis as previously described. This completes a rigid connection between the parts 94, 90 and 91 so that the gasket 91 may be reciprocated in the barrel 87 if desired.

Note that in every case I have provided a mixing syringe having a mixing chamber closed except for an inlet and an outlet and a second measured ingredient chamber having a closed but breachable passageway communicating with the mixing chamber inlet. Means is provided for opening the breachable passageway and for propelling the contents of the ingredient chamber into the mixing chamber with the ingredient already placed there after which the mixing chamber may be shaken to thoroughly mix the contents. Means is provided then for propelling the contents of the mixing chamber through the outlet to inject a patient. This provides a quick and easy manner of mixing two ingredients in place in a syringe just before injecting a pateint and is an improvement over methods previously known.

What is claimed is:

1. A combined mixing and injecting syringe comprising an outer first-ingredient-retaining barrel open at one end and having a discharge outlet at the other end, an inner second-ingredient-retaining barrel open at one end and having a discharge opening at its other end, breachable means initially closing said discharge opening, said other end having means for sealing engagement with the interior surface of said outer barrel and being movable axially in said outer barrel, a plunger adapted to sealingly engage the interior surface of said inner barrel and movable axially endwise of said inner barrel, whereby a first ingredient of a mixture may be placed in said outer barrel and held there by said inner barrel, and a second ingredient of said mixture may be placed in said inner barrel and held there by said plunger, after which said breachable means may be opened and said second ingredient may be propelled, by manipulation of said plunger, through said discharge opening into said first ingredient in said outer barrel, said two ingredients may be mixed there, and then said mixture may be propelled by said inner barrel through said discharge outlet, and wherein said means for sealingly engaging between said inner barrel and said outer barrel comprises a gasket impervious at the inner end of said inner barrel to provide said breachable means there, a hollow needle has one end substantially in engagement with said gasket and has its other end in position to communicate with said inner barrel, means is provided for relative movement of said inner barrel against said other end of said needle and for causing said needle to perforate said gasket, after which said ingredients may be mixed and said mixture may be propelled out of said discharge outlet.

2. A syringe as defined in claim 1 wherein said last named means comprises a hollow neck on said inner barrel having a threaded connection with said gasket, a needle-penetratable seal closing said neck on the upstream side of said needle, said outer barrel and said gasket being non-circular in section whereby turning of said inner barrel about its longitudinal axis will operate said threaded connection to advance said neck into said gasket causing said needle to perforate said seal, and there being inter-engageable parts on said neck and needle adapted to drive said needle through said gasket by operation of said threaded connection.

3. A syringe as defined in claim 1 wherein said last named means comprises a neck on said inner barrel having a threaded connection with said gasket, said needle rigidly carried by said neck with said other end of said hollow needle in communication with said inner barrel, said gasket having a portion extending outside said open end of said outer barrel for grasping by an operator in order to operate said threaded connection, the proportioning of the parts permitting such operation to drive said needle through said gasket.

4. A syringe as defined in claim 3, including a rigid connection between said plunger and said neck engageable by said plunger upon propelling said second ingredient out of said inner barrel and enabling reciprocation of said plunger and said gasket as a unit.

References Cited UNITED STATES PATENTS 2,724,383 11/1955 Lockhart 128272 XR 2,869,543 1/1959 Ratclifi et al. 3,336,924 8/1967 Sarnoff et al. 3,326,215 1/1967 Sarnoff et al. 128-272 XR FOREIGN PATENTS 815,749 7/1959 Great Britain.

RICHARD A. GAUDET, Primary Examiner MARTIN F. MAJESTIC, Assistant Examiner US. Cl. X.R.

US3489147D 1964-07-21 1967-08-22 Combination mixing and injecting medical syringe Expired - Lifetime US3489147A (en)

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US3570486A (en) * 1968-10-14 1971-03-16 Horizon Ind Ltd Mixing syringe
US3630199A (en) * 1970-05-26 1971-12-28 Louis P Gangarosa Unitized injection system
US3636950A (en) * 1968-11-14 1972-01-25 American Home Prod Disposable cartridge for admixing two components of injectable medicament
US3819037A (en) * 1972-08-28 1974-06-25 Minnesota Mining & Mfg Cable plugging apparatus
US3826261A (en) * 1971-12-27 1974-07-30 Upjohn Co Vial and syringe assembly
US3845763A (en) * 1973-02-28 1974-11-05 Nasco Plastics Inc Syringe with puncturable stem
US3857392A (en) * 1969-06-04 1974-12-31 Ims Ltd Intravenous container with dislodgeable septum and dislodging piercer
US4014330A (en) * 1975-10-28 1977-03-29 Abbott Laboratories Disposable two-compartment syringe
US4036225A (en) * 1974-09-19 1977-07-19 Maury Jean Robert Bicompartmental syringe
US4054138A (en) * 1974-12-30 1977-10-18 Louis Bucalo Implants for acting on living beings
US4055177A (en) * 1976-05-28 1977-10-25 Cohen Milton J Hypodermic syringe
FR2400368A1 (en) * 1977-08-15 1979-03-16 Abbott Lab Prefilled syringe has two compartments
FR2508341A1 (en) * 1981-06-29 1982-12-31 Dupont Philippe Device for the mixture after two or more components
US4581015A (en) * 1984-05-10 1986-04-08 Alfano C Michael Multimedication syringe
US4676406A (en) * 1983-12-10 1987-06-30 Upat & Co., Gmbh Squirt cartridge for mixing and dispensing a two-component mass
US4861335A (en) * 1985-07-26 1989-08-29 Duoject Medical Systems Inc. Syringe
US4886495A (en) * 1987-07-08 1989-12-12 Duoject Medical Systems Inc. Vial-based prefilled syringe system for one or two component medicaments
US5050774A (en) * 1989-06-13 1991-09-24 Camm James O Combination mixer dispenser
US5181629A (en) * 1989-06-13 1993-01-26 Camm James O Combination mixer dispenser
US5286258A (en) * 1991-03-08 1994-02-15 Habley Medical Technology Corporation Multipharmaceutical delivery system
US5364369A (en) * 1987-07-08 1994-11-15 Reynolds David L Syringe
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ES2074024A1 (en) * 1993-03-10 1995-08-16 Melamed Jaime Luis Szapiro Disposable two-chamber syringe for the simultaneous dilution and administration of a medicinal product
US5779668A (en) * 1995-03-29 1998-07-14 Abbott Laboratories Syringe barrel for lyophilization, reconstitution and administration
US5785682A (en) * 1995-03-22 1998-07-28 Abbott Laboratories Pre-filled syringe drug delivery system
US5876372A (en) * 1995-03-22 1999-03-02 Abbott Laboratories Syringe system accomodating seperate prefilled barrels for two constituents
WO2000057835A1 (en) * 1999-03-27 2000-10-05 Smithkline Beecham Biologicals S.A. Teat nozzle for dosing device with connection means
US6302574B1 (en) * 1995-06-06 2001-10-16 Kwan-Ho Chan Prepackaged liquid bone cement dispenser
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US20040171984A1 (en) * 2002-08-30 2004-09-02 Greenfield Christian John Syringe for sequential delivery of different fluids
US20050177100A1 (en) * 2003-10-24 2005-08-11 Harper Derek J. Dual chamber mixing syringe and method for use
US7007829B1 (en) * 2003-02-19 2006-03-07 Chief Packaging Company, Llc Hollow handle push-up piston for a food container
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US20080195059A1 (en) * 2007-02-14 2008-08-14 Daikyo Seiko, Ltd. Syringe barrel and syringe
US20080312588A1 (en) * 2005-05-20 2008-12-18 Giovanni Faccioli Cartridge For Storage and Delivery of a Two-Phase Compound
US20090082751A1 (en) * 2007-06-13 2009-03-26 Reynolds David L Device for transferring fluid from a cartridge to a container
US20090314803A1 (en) * 2006-08-22 2009-12-24 Medmix Systems Ag Device and method for storing, mixing and dispensing components
US20100010472A1 (en) * 2004-12-24 2010-01-14 Ian Marshall Moore Safety syringe
US20100100099A1 (en) * 2008-06-24 2010-04-22 Tayla Reilly Curable material transfer and delivery device
US20110176382A1 (en) * 2010-01-15 2011-07-21 Spine Wave, Inc. Systems and Methods for Mixing Fluids
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US20170312449A1 (en) * 2014-10-21 2017-11-02 Sulzer Mixpac Ag Dual-chamber syringe
USD807502S1 (en) 2015-03-02 2018-01-09 Neomed, Inc. Enteral syringe
USD831203S1 (en) 2015-03-02 2018-10-16 Neomed, Inc. Enteral syringe
USD831204S1 (en) 2015-03-02 2018-10-16 Neomed, Inc. Enteral syringe
US10307337B2 (en) 2015-03-24 2019-06-04 Neomed, Inc. Oral administration coupler for back-of-mouth delivery
US10369294B2 (en) * 2010-07-22 2019-08-06 Kevin Abbott Fluid dose dispensing apparatus
US10420709B2 (en) 2015-07-14 2019-09-24 Neomed, Inc. Dosing control coupling for enteral fluid transfer

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US2869543A (en) * 1957-08-23 1959-01-20 Iowa Cooperative Ass Injector
GB815749A (en) * 1955-10-18 1959-07-01 Produfarma Limitada Improvements in or relating to syringes
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US3630199A (en) * 1970-05-26 1971-12-28 Louis P Gangarosa Unitized injection system
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US6302574B1 (en) * 1995-06-06 2001-10-16 Kwan-Ho Chan Prepackaged liquid bone cement dispenser
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