US3475950A - Chromatograph sample system - Google Patents

Chromatograph sample system Download PDF

Info

Publication number
US3475950A
US3475950A US527325A US3475950DA US3475950A US 3475950 A US3475950 A US 3475950A US 527325 A US527325 A US 527325A US 3475950D A US3475950D A US 3475950DA US 3475950 A US3475950 A US 3475950A
Authority
US
United States
Prior art keywords
sample
plug
passage
housing
column
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US527325A
Inventor
Charles R Ferrin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INVALCO Inc
Combustion Engineering Inc
Original Assignee
Combustion Engineering Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Combustion Engineering Inc filed Critical Combustion Engineering Inc
Application granted granted Critical
Publication of US3475950A publication Critical patent/US3475950A/en
Assigned to INVALCO, INC. reassignment INVALCO, INC. ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: COMBUSTION ENGINEERING, IN., A CORP OF DE.
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/22—Injection in high pressure liquid systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve

Definitions

  • the movable element of a valve has a passage in which a high pressure liquid sample is inserted and transferred to a chromatographic column.
  • a source of sealing fluid is connected to the valve to apply the high pressure fluid to the sealing surface about the valve passage to prevent leakage of the sample.
  • the present invention relates to a method and apparatus of inserting a sample of high pressure liquid into a chromatograph column. More particularly, the invention relates to providing a pressure system for a sample transfer valve which will effectively control a liquid sample transferred by the valve from a source of sample to a chromatograph column.
  • the principal object of the present invention is to apply suflicient fluid pressure across the sealing surface of a valve element which is about the ends of a sample-containing passage in the valve element while the transfer of the sample to connection with a chromatograph column is being made.
  • Another object is to provide for ejection of the high pressure liquid sample from the valve passage without interruption of the flow of this sample from the passage into the chromatograph column.
  • the present invention contemplates providing a plug valve for transferring a high pressure liquid sample.
  • a valve passage in the plug is supplied the sample of high pressure liquid for chromatograph analysis. While the sample is held in the plug passage, a separate source of pressure is maintained on the sealing surface of the plug; the pressure being at least equal to that of the sample to thereby militate against leakage of the sample from the passage. The pressure on the sealing surface is maintained while the plug is positioned to connect the plug passage to the column.
  • the invention further contemplates a source of fluid for ejecting the sample from the plug passage.
  • the source of ejection fluid is sized so it will eject the sample from the plug passage without interruption of its continuous flow into the column.
  • FIG. 1 is a partially sectioned side elevation of a high pressure liquid entrance system for a chromatograph in which the present invention is embodied;
  • FIG. 2 is a sectioned plan view of FIG. 1 along lines
  • FIG. 3 is a view similar to FIG. 2 but with the plug of the valve positioned to eject the liquid sample into the column;
  • FIG. 4 is a view similar to FIG. 1 but with a valve plug arranged with an internal passage to develop the balancing pressure on the plug.
  • the broad scope of the invention is one of obtaining a very small volume of high pressure liquid and ejecting it into a stream of carrier gas for conveyance into, and through, a chromatograph column.
  • a small passage can be formed in a valve plug for the liquid sample.
  • the sample can be trapped in this volume.
  • the slightest wear, or imperfection results in an escape of some part of the liquid sample.
  • the difference in pressure between that of the sample in the plug passage and ambient pressure on the other side of the sealing surface has been great enough to permit the escape of some of the sample.
  • the chromatograph analysis has, heretofore, been inconsistent and inaccurate under these circumstances.
  • the present invention simply eliminates the pressure differential. A fluid pressure is generated on the sealing surface surrounding the plug passage to reduce its pressure differential with the sample until no leakage of the sample takes place. This pressure is maintained on the valve plug while it is positioned and no sample can escape.
  • FIGS. l-3 illustrate one embodiment of the invention in a system including a valve 1 with its housing 2 connected to the necessary sources of fluids to be passed into a chromatograph column for analysis.
  • Plug 3 of the valve has a passage 4 which receives the sample of high pressure liquid to be analyzed.
  • the sealing surface 5 of plug 3 extends about the ends of passage 4, sealing against the walls of housing cavity 6.
  • Housing cavity 6 has a volume 6A on one side of plug sealing surface 5 and volume 6B on the other side of the plug sealing surface.
  • Source 7 simultaneously develops a fluid pressure in housing volumes 6A and 63 great enough to retain the fluid sample in plug passage 4, eifectively isolated. The plug can then be rotated to the position disclosed in FIG. 3 and the sample properly ejected from passage 4 and into the column.
  • FIGS. 1-3 Details of FIGS. 1-3
  • Plug valves are well-known devices. The employment of Teflon plastic as the movable element of such valves is also well-known. The self-lubricating qualities of this material are generally understood and appreciated.
  • Plug 3 is shown here as mounted on the end of a metallic base 10 and turned by shaft 11 while spring-urged with spring 12 into sealing engagement with the walls of cavity 6. These parts are precision made in order to maintain alignment between plug passage 4 and passages through the walls of housing 2.
  • FIGS. 2 and 3 show plug passage 4 rotated from the position at which it is filled with a sample to a position at which that sample is ejected from passage 4 and into a chromatograph column.
  • the sample source is not shown. It is only required for conduit 13 be disclosed, conducting the sample to housing passage 14. From passage 14, the
  • plug passage 4 high pressure sample flows into plug passage 4.
  • a stream of the sample liquid is flowed through passage 4, housing passage 15 and is discharged through conduit 16.
  • plug 3 is rotated to connect plug passage 4 as shown in FIG. 3.
  • Gas from source 17 then ejects the liquid sample from plug passage 4 and into conduit 18 for entrance into the chromatograph column not shown.
  • a source of carrier gas is indicated at 19. This source is connected to housing passage 20 so it will convey the ejected sample into, and through, the column. Housing passage 21 is shown in simple T connection to passage 20, flowing the carrier gas into passage 20.
  • the pressure of the carrier gas source is only slightly above atmospheric. Therefore, it is possible that the ejecting gas from source 17 could push the sample from plug passage 4 so fast that its pressure would cause a part of the sample to flow up housing passage 21 for a finite distance. This side-track of a portion of the sample interrupts the smooth flow desired for the sample into the column, causing double indications of the same components.
  • the quantity of ejecting gas should be fixed at a value which will cause all the sample to flow past housing passage 21 smoothly, without interruption.
  • a volume of ejecting gas could .be isolated between valves and released when plug passage 4 is positioned as shown in FIG. 3. The result would be a smooth, continuous, uninterrupted flow of the sample into the column.
  • FIG. 4 represents a more simple and efficient way to apply the sealing gas pressure to the sealing surface of a plug valve.
  • Valve 31 has a housing 32 similar to the structure of FIG. 1.
  • Plug 33 has a passage 34 for the high pressure liquid sample.
  • the sealing surface 35 of plug 33 extends about the ends of passage 34, sealing against the walls of housing cavity 36.
  • Housing cavity 36 has a volume 36A on one side of plug sealing surface 35 and volume 36B on the other side of the plug sealing surface.
  • Source 37 simultaneously develops pressure in housing volumes 36A and 363 through passageway 38 in plug 33.
  • Passageway 38 extends from plug face 39 to plug face 39A and equalizes the pressures of 36A and 36B.
  • the passageway can be formed as shown.
  • a pin from base 40 extending into the body of plug 33 is disclosed with an axial bore to which a passage in the plastic body of plug 33 connects.
  • the concept is to have this passageway 38 equalize the sealing pressure of source 37 at faces 39, 39A, or in volumes 36A and 36B, placing the complete sealing surface about sample passage 34 under the sealing pressure.
  • a system for injecting a sample of high pressure liquid to be analyzed into a chromatographic column including:
  • valve housing having a cavity whose walls comprise a sealing surface for a valve plug
  • valve plug positioned in the housing cavity to bring its outer surface into sealing engagement with the cavity walls
  • a source of high pressure liquid sample communicated with the first passage to conduct a sample of the liquid into the plug passage when the plug is in the first of its positions
  • a chomatographic column connected to the second housing passage to receive the sample and carrier gas for analysis of the sample
  • a third passage in the housing located to supply a fluid pressure at least as great as that of the sample to the sealing engagement between the outer surface of the plug and the cavity walls to prevent escape of high pressure liquid from the plug passage before transfer of the sample to the column.

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Fluid Mechanics (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Description

Nov. 4, 1969 c. R. FERRIN 3,475,950
CHROMATOGRAPH SAMPLE SYSTEM Filed Feb. 14. 1966 2 Sheets-Sheet 1 SOURCE CARR/E SOURCE OF COLUM T0 CHROMATOGR I7 I To saunas 0F CHROMATOGRAPH EJECTING COLUMN DISCHARGE OF SAMPLE INVENTOR.
f fl 2- CHARLES R. FERRIN ATTORNEY Nov.'4, 1969 c. R. FERRIN 3,475,950
CHROMATOGRAPH SAMPLE SYSTEM Filed Feb. 14, 1966 2 Sheets-Sheet 2 SOURCE OF A EJECT/NG COLUMN SOURCE OF SOURCE OF ggr SEALING GAS.
7'0 SOURCE OF CHROMATOGRAPH EJECT/NG COLUMN 645 I- .n :R l 0 39A 36B 1 l I INVENTOR.
QHARLES R. FERRIN ATTORNEY United States Patent US. U. 73-23.]l 2 Claims ABSTRAQT OF THE DISCLUSURE The movable element of a valve has a passage in which a high pressure liquid sample is inserted and transferred to a chromatographic column. A source of sealing fluid is connected to the valve to apply the high pressure fluid to the sealing surface about the valve passage to prevent leakage of the sample.
The present invention relates to a method and apparatus of inserting a sample of high pressure liquid into a chromatograph column. More particularly, the invention relates to providing a pressure system for a sample transfer valve which will effectively control a liquid sample transferred by the valve from a source of sample to a chromatograph column.
One of the difficult problems in the art of chromatography is the transfer of a prepared sample of high pressure liquid into a chromatograph column. The nature of the chromatograph columns make it necessary to supply small volumes of high pressure liquid samples. It is extremely diflicult to effectively isolate small sample volumes of high pressure liquid with mechanical valving structures and transfer this sample of liquid into a stream of carrier gas for entry into the column. The mechanical elements of valving structure are subject to wear with the development of subsequent leaks.
The principal object of the present invention is to apply suflicient fluid pressure across the sealing surface of a valve element which is about the ends of a sample-containing passage in the valve element while the transfer of the sample to connection with a chromatograph column is being made.
Another object is to provide for ejection of the high pressure liquid sample from the valve passage without interruption of the flow of this sample from the passage into the chromatograph column.
The present invention contemplates providing a plug valve for transferring a high pressure liquid sample. A valve passage in the plug is supplied the sample of high pressure liquid for chromatograph analysis. While the sample is held in the plug passage, a separate source of pressure is maintained on the sealing surface of the plug; the pressure being at least equal to that of the sample to thereby militate against leakage of the sample from the passage. The pressure on the sealing surface is maintained while the plug is positioned to connect the plug passage to the column.
The invention further contemplates a source of fluid for ejecting the sample from the plug passage. The source of ejection fluid is sized so it will eject the sample from the plug passage without interruption of its continuous flow into the column.
Having generally described the invention, it will now be explained in more detail by reference to the accompanying drawings showing preferred embodiments of it and in which;
FIG. 1 is a partially sectioned side elevation of a high pressure liquid entrance system for a chromatograph in which the present invention is embodied;
3,475,950 Patented Nov. 4, 1969 "ice 2 12G. 2 is a sectioned plan view of FIG. 1 along lines FIG. 3 is a view similar to FIG. 2 but with the plug of the valve positioned to eject the liquid sample into the column; and
FIG. 4 is a view similar to FIG. 1 but with a valve plug arranged with an internal passage to develop the balancing pressure on the plug.
The broad scope of the invention The problem is one of obtaining a very small volume of high pressure liquid and ejecting it into a stream of carrier gas for conveyance into, and through, a chromatograph column. A small passage can be formed in a valve plug for the liquid sample. The sample can be trapped in this volume. However, in present practice, as the plug is positioned, the slightest wear, or imperfection, results in an escape of some part of the liquid sample. The difference in pressure between that of the sample in the plug passage and ambient pressure on the other side of the sealing surface has been great enough to permit the escape of some of the sample. The chromatograph analysis has, heretofore, been inconsistent and inaccurate under these circumstances.
The present invention simply eliminates the pressure differential. A fluid pressure is generated on the sealing surface surrounding the plug passage to reduce its pressure differential with the sample until no leakage of the sample takes place. This pressure is maintained on the valve plug while it is positioned and no sample can escape.
The general system embodying the invention FIGS. l-3 illustrate one embodiment of the invention in a system including a valve 1 with its housing 2 connected to the necessary sources of fluids to be passed into a chromatograph column for analysis. Plug 3 of the valve has a passage 4 which receives the sample of high pressure liquid to be analyzed. The sealing surface 5 of plug 3 extends about the ends of passage 4, sealing against the walls of housing cavity 6.
Housing cavity 6 has a volume 6A on one side of plug sealing surface 5 and volume 6B on the other side of the plug sealing surface. Source 7 simultaneously develops a fluid pressure in housing volumes 6A and 63 great enough to retain the fluid sample in plug passage 4, eifectively isolated. The plug can then be rotated to the position disclosed in FIG. 3 and the sample properly ejected from passage 4 and into the column.
Under this concept, the sealing of the high pressure liquid sample is not solely dependent upon the effectiveness of the mechanical seal between the walls of plug 4 and the walls of housing cavity 6. The pressure applied to each end of plug 3 accomplishes what mechanical sealing has :failed to do in this art.
Details of FIGS. 1-3
Plug valves are well-known devices. The employment of Teflon plastic as the movable element of such valves is also well-known. The self-lubricating qualities of this material are generally understood and appreciated. Plug 3 is shown here as mounted on the end of a metallic base 10 and turned by shaft 11 while spring-urged with spring 12 into sealing engagement with the walls of cavity 6. These parts are precision made in order to maintain alignment between plug passage 4 and passages through the walls of housing 2.
FIGS. 2 and 3 show plug passage 4 rotated from the position at which it is filled with a sample to a position at which that sample is ejected from passage 4 and into a chromatograph column. The sample source is not shown. It is only required for conduit 13 be disclosed, conducting the sample to housing passage 14. From passage 14, the
high pressure sample flows into plug passage 4. In actual practice, a stream of the sample liquid is flowed through passage 4, housing passage 15 and is discharged through conduit 16. When experience dictates the sample flowing through plug passage 4 is representative of the liquid to be tested, plug 3 is rotated to connect plug passage 4 as shown in FIG. 3. Gas from source 17 then ejects the liquid sample from plug passage 4 and into conduit 18 for entrance into the chromatograph column not shown.
A source of carrier gas is indicated at 19. This source is connected to housing passage 20 so it will convey the ejected sample into, and through, the column. Housing passage 21 is shown in simple T connection to passage 20, flowing the carrier gas into passage 20.
The pressure of the carrier gas source is only slightly above atmospheric. Therefore, it is possible that the ejecting gas from source 17 could push the sample from plug passage 4 so fast that its pressure would cause a part of the sample to flow up housing passage 21 for a finite distance. This side-track of a portion of the sample interrupts the smooth flow desired for the sample into the column, causing double indications of the same components.
To avoid this interruption in flow, the quantity of ejecting gas should be fixed at a value which will cause all the sample to flow past housing passage 21 smoothly, without interruption. A volume of ejecting gas could .be isolated between valves and released when plug passage 4 is positioned as shown in FIG. 3. The result would be a smooth, continuous, uninterrupted flow of the sample into the column.
Preferred embodiment FIG. 4 represents a more simple and efficient way to apply the sealing gas pressure to the sealing surface of a plug valve. Valve 31 has a housing 32 similar to the structure of FIG. 1. Plug 33 has a passage 34 for the high pressure liquid sample. The sealing surface 35 of plug 33 extends about the ends of passage 34, sealing against the walls of housing cavity 36.
Housing cavity 36 has a volume 36A on one side of plug sealing surface 35 and volume 36B on the other side of the plug sealing surface. Source 37 simultaneously develops pressure in housing volumes 36A and 363 through passageway 38 in plug 33.
Passageway 38 extends from plug face 39 to plug face 39A and equalizes the pressures of 36A and 36B. The passageway can be formed as shown. A pin from base 40 extending into the body of plug 33 is disclosed with an axial bore to which a passage in the plastic body of plug 33 connects. However, specifically disclosed here, the concept is to have this passageway 38 equalize the sealing pressure of source 37 at faces 39, 39A, or in volumes 36A and 36B, placing the complete sealing surface about sample passage 34 under the sealing pressure.
From the foregoing it will be seen that this invention is one well adapted to attain all of the ends and objects hereinabove set forth, together with other advantages which are obvious and which are inherent to the method and apparatus.
It will be understood that certain features and subcombinations are of utility and may be employed without reference to other features and subcombinations. This is contemplated by and is within the scope of the claims.
As many possible embodiments may be made of the invention without departing from the scope thereof, it is to be understood that all matter herein set forth or shown in the accompanying drawings is to be interpreted as illustrative and not in a limiting sense.
The present invention having been described, what is claimed is:
1. A system for injecting a sample of high pressure liquid to be analyzed into a chromatographic column, including:
a valve housing having a cavity whose walls comprise a sealing surface for a valve plug,
a valve plug positioned in the housing cavity to bring its outer surface into sealing engagement with the cavity walls,
a passage formed in the plug to extend to the sealing surfaces of the cavity and plug walls,
a first passage in the housing which is located to register with the plug passage in a first of the positions to which the plug is rotated,
a source of high pressure liquid sample communicated with the first passage to conduct a sample of the liquid into the plug passage when the plug is in the first of its positions,
a second passage in the housing which is located to register with the plug passage in a second of the positions to which the plug is rotated,
means for ejecting the sample from the plug passage into the second housing passage,
a source of carrier gas at a pressure substantially less than that of the sample connected to the second housing passage,
a chomatographic column connected to the second housing passage to receive the sample and carrier gas for analysis of the sample, and
a third passage in the housing located to supply a fluid pressure at least as great as that of the sample to the sealing engagement between the outer surface of the plug and the cavity walls to prevent escape of high pressure liquid from the plug passage before transfer of the sample to the column.
2. The system of claim 1 having a passage system including the third housing passage arranged to apply the fluid pressure to both sides of the valve plug in the housing cavity to balance the forces on the plug from the fluid pressure.
References Cited UNITED STATES PATENTS 3,267,736 8/1966 Boettger 73-422 2,315,058 3/1943 Holt et al l37240 3,183,925 5/1965 Hoyle et al. 137-24614 3,181,552 5/1965 Jackson 137-246.12 3,318,154 5/ 1967 Rendina 73422 3,306,111 2/1967 Ferrin 73-23.1
RICHARD C. 'QUEISSER, Primary Examiner VICTOR J. TOTH, Assistant Examiner US. Cl. X.R. 73-422
US527325A 1966-02-14 1966-02-14 Chromatograph sample system Expired - Lifetime US3475950A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52732566A 1966-02-14 1966-02-14

Publications (1)

Publication Number Publication Date
US3475950A true US3475950A (en) 1969-11-04

Family

ID=24101020

Family Applications (1)

Application Number Title Priority Date Filing Date
US527325A Expired - Lifetime US3475950A (en) 1966-02-14 1966-02-14 Chromatograph sample system

Country Status (1)

Country Link
US (1) US3475950A (en)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641822A (en) * 1969-10-01 1972-02-15 Rano J Harris Sr Fluid sample injection valve
US3675466A (en) * 1970-08-19 1972-07-11 Hydronautics Sampling valve and system for the detection of predetermined compounds in air
US3975946A (en) * 1974-02-27 1976-08-24 Micromeritics Instrument Corporation Liquid chromatography sample measuring and introducing apparatus
US3999439A (en) * 1974-07-22 1976-12-28 Varian Associates High pressure sample injector and injection method
US4359891A (en) * 1981-01-05 1982-11-23 The Dow Chemical Company Repetitive chromatographic apparatus
EP0101601A1 (en) * 1982-08-12 1984-02-29 General Signal Corporation Sampling apparatus
FR2535848A1 (en) * 1982-11-08 1984-05-11 Commissariat Energie Atomique Device for sampling a fluid, sampling method employing the device and application to the dilution of a fluid
US4660424A (en) * 1984-11-06 1987-04-28 Lars Ljungberg, Lab Trade Ab Metering valve
US4917864A (en) * 1987-05-12 1990-04-17 Avl Ag Device for feeding an analyzing apparatus
US4967590A (en) * 1989-09-18 1990-11-06 Und-Sem Foundation Supercritical fluid chromatography injector and the method for using the same
US5419208A (en) * 1993-01-29 1995-05-30 Upchurch Scientific, Inc. Multiport selection valve
US5866072A (en) * 1996-02-26 1999-02-02 Cds Analytical, Inc. Analytical pyrolysis autosampler
US20160077062A1 (en) * 2013-04-30 2016-03-17 Hamilton Bonaduz Ag Sample dispenser for an analytical device
EP2192857B1 (en) * 2007-09-27 2017-03-22 Roche Diagnostics GmbH Bodily fluid extraction and infusion system and operating method
US10371672B1 (en) * 2015-04-15 2019-08-06 Yury Zelechonok Integrated chromatography column injector detector device
WO2020152495A1 (en) * 2019-01-22 2020-07-30 Total Sa Injection valve for an analysis apparatus
US11415502B2 (en) * 2019-12-10 2022-08-16 Uchicago Argonne, Llc Flow cell sample generator
US11933734B2 (en) 2021-06-17 2024-03-19 Uchicago Argonne, Llc Open aperture flow cells for on-line optical analysis of process fluids

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2315058A (en) * 1940-04-12 1943-03-30 Standard Oil Dev Co Plug cock for handling powdered materials
US3181552A (en) * 1961-09-26 1965-05-04 Mcevoy Co Valves with enhanced pressure actuated seals
US3183925A (en) * 1963-05-14 1965-05-18 Audco Ltd Plug valve having a particular lubricant sealant arrangement
US3267736A (en) * 1964-01-20 1966-08-23 Cons Electrodynamics Corp Chromatographic sampling valve
US3306111A (en) * 1964-12-07 1967-02-28 Combustion Eng Chromatograph sample system
US3318154A (en) * 1965-02-26 1967-05-09 Hewlett Packard Co Sampling apparatus

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2315058A (en) * 1940-04-12 1943-03-30 Standard Oil Dev Co Plug cock for handling powdered materials
US3181552A (en) * 1961-09-26 1965-05-04 Mcevoy Co Valves with enhanced pressure actuated seals
US3183925A (en) * 1963-05-14 1965-05-18 Audco Ltd Plug valve having a particular lubricant sealant arrangement
US3267736A (en) * 1964-01-20 1966-08-23 Cons Electrodynamics Corp Chromatographic sampling valve
US3306111A (en) * 1964-12-07 1967-02-28 Combustion Eng Chromatograph sample system
US3318154A (en) * 1965-02-26 1967-05-09 Hewlett Packard Co Sampling apparatus

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641822A (en) * 1969-10-01 1972-02-15 Rano J Harris Sr Fluid sample injection valve
US3675466A (en) * 1970-08-19 1972-07-11 Hydronautics Sampling valve and system for the detection of predetermined compounds in air
US3975946A (en) * 1974-02-27 1976-08-24 Micromeritics Instrument Corporation Liquid chromatography sample measuring and introducing apparatus
US3999439A (en) * 1974-07-22 1976-12-28 Varian Associates High pressure sample injector and injection method
US4359891A (en) * 1981-01-05 1982-11-23 The Dow Chemical Company Repetitive chromatographic apparatus
EP0101601A1 (en) * 1982-08-12 1984-02-29 General Signal Corporation Sampling apparatus
FR2535848A1 (en) * 1982-11-08 1984-05-11 Commissariat Energie Atomique Device for sampling a fluid, sampling method employing the device and application to the dilution of a fluid
US4660424A (en) * 1984-11-06 1987-04-28 Lars Ljungberg, Lab Trade Ab Metering valve
US4917864A (en) * 1987-05-12 1990-04-17 Avl Ag Device for feeding an analyzing apparatus
US4967590A (en) * 1989-09-18 1990-11-06 Und-Sem Foundation Supercritical fluid chromatography injector and the method for using the same
US5419208A (en) * 1993-01-29 1995-05-30 Upchurch Scientific, Inc. Multiport selection valve
US5866072A (en) * 1996-02-26 1999-02-02 Cds Analytical, Inc. Analytical pyrolysis autosampler
EP2192857B1 (en) * 2007-09-27 2017-03-22 Roche Diagnostics GmbH Bodily fluid extraction and infusion system and operating method
US20160077062A1 (en) * 2013-04-30 2016-03-17 Hamilton Bonaduz Ag Sample dispenser for an analytical device
US10078072B2 (en) * 2013-04-30 2018-09-18 Hamilton Bonaduz Ag Sample dispenser for an analytical device
US10371672B1 (en) * 2015-04-15 2019-08-06 Yury Zelechonok Integrated chromatography column injector detector device
WO2020152495A1 (en) * 2019-01-22 2020-07-30 Total Sa Injection valve for an analysis apparatus
US12007034B2 (en) 2019-01-22 2024-06-11 Totalenergies Onetech (Previously Totalenergies One Tech) Injection valve for an analysis apparatus
US11415502B2 (en) * 2019-12-10 2022-08-16 Uchicago Argonne, Llc Flow cell sample generator
US11933734B2 (en) 2021-06-17 2024-03-19 Uchicago Argonne, Llc Open aperture flow cells for on-line optical analysis of process fluids

Similar Documents

Publication Publication Date Title
US3475950A (en) Chromatograph sample system
Spackman [1] Accelerated methods
US3149941A (en) Chromatography apparatus
Gritti et al. On the minimization of the band-broadening contributions of a modern, very high pressure liquid chromatograph
US4962042A (en) Method for on-column injection gas chromatography
US4059009A (en) Liquid chromatography system
US7779670B2 (en) Two valve switching modulator for comprehensive two-dimensional gas chromatography
ES451650A1 (en) Plastics ball valve
GB949067A (en) Dual column gas chromatograph and method for analysis
CA1055723A (en) Chromatograph injection system
US3444722A (en) Device for supplying carrier gas to transport eluted portion of sample and to backflush chromatographic column
US4879029A (en) Liquid chromatograph apparatus
US2972888A (en) Fluid sampling and injection valve
US20080290309A1 (en) Pin Valve Assembly
US3357232A (en) Analyzing apparatus with pressure-actuated fluid valving system
US3787026A (en) Chromatography valve
US3368385A (en) Sample system for chromatographic analyzers
US3489011A (en) Sampling valve
US3166939A (en) Sample valve
Stoll Essentials of LC Troubleshooting, Part I: Pressure Problems
JPH0370180B2 (en)
US3511080A (en) Valveless system for transferring sample from sample loop through column to detector
US3431783A (en) Chromatograph tape septum injection port
US3162050A (en) Sample valve
TWI256471B (en) Liquid chromatograph and analysis system

Legal Events

Date Code Title Description
AS Assignment

Owner name: INVALCO, INC., OKLAHOMA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:COMBUSTION ENGINEERING, IN., A CORP OF DE.;REEL/FRAME:004561/0886

Effective date: 19860210

Owner name: INVALCO, INC., 1305 NORTH LOUISVILLE, TULSA, OK.,

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:COMBUSTION ENGINEERING, IN., A CORP OF DE.;REEL/FRAME:004561/0886

Effective date: 19860210